• 1198 Citations
  • 19 Scopus h-Index
20012019
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Research Output 2001 2019

  • 1198 Citations
  • 19 Scopus h-Index
  • 37 Article
  • 3 Chapter
  • 1 Comment/debate
  • 1 Review article
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Article
2019
2 Citations (Scopus)

3D printing for bio-synthetic biliary stents

Boyer, C. J., Boktor, M., Samant, H., White, L. A., Wang, Y., Ballard, D. H., Huebert, R. C., Woerner, J. E., Ghali, G. E. & Alexander, J. S., Jan 1 2019, In : Bioengineering. 6, 1, 16.

Research output: Contribution to journalArticle

Open Access
Stents
Printing
Stem cells
Collagen
3D printers
5 Citations (Scopus)

Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis

Martin-Mateos, R., De Assuncao, T. M., Arab, J. P., Jalan-Sakrikar, N., Yaqoob, U., Greuter, T., Verma, V. K., Mathison, A. J., Cao, S., Lomberk, G., Mathurin, P., Urrutia, R., Huebert, R. C. & Shah, V., Jan 1 2019, In : CMGH. 7, 1, p. 197-209 13 p.

Research output: Contribution to journalArticle

Hepatic Stellate Cells
Transforming Growth Factors
Liver Cirrhosis
Platelet-Derived Growth Factor
Carbon Tetrachloride

Proteasomal Degradation of Enhancer of Zeste Homologue 2 in Cholangiocytes Promotes Biliary Fibrosis

Jalan-Sakrikar, N., De Assuncao, T. M., Shi, G., Aseem, S. O., Chi, C., Shah, V. & Huebert, R. C., Jan 1 2019, In : Hepatology.

Research output: Contribution to journalArticle

Transforming Growth Factors
Fibrosis
Fibronectins
Hepatic Stellate Cells
Ubiquitin
2018

Epigenetics of gastrointestinal diseases: notes from a workshop

Marks, D. L., Olson, R. L., Urrutia, R., Billadeau, D. D., Roy, N., Calin, G. A., Fabbri, M., Koutsioumpa, M., Iliopoulos, D., Ordog, T., Huebert, R. C., Sarmento, O., Bamidele, A. O., Faubion, W. A., Lomberk, G. L., Siveke, J., Ahuja, N., Iovanna, J., Hlady, R. A., Robertson, K. D. & 3 others, Kisiel, J. B., Pin, C. L. & Fernandez-Zapico, M. E., Apr 3 2018, In : Epigenetics. 13, 4, p. 449-457 9 p.

Research output: Contribution to journalArticle

Gastrointestinal Diseases
Epigenomics
Education
DNA Methylation
Biomarkers
2017
5 Citations (Scopus)

Combined AURKA and H3K9 methyltransferase targeting inhibits cell growth by inducing mitotic catastrophe

Mathison, A., Salmonson, A., Missfeldt, M., Bintz, J., Williams, M., Kossak, S., Nair, A., De Assuncao, T. M., Christensen, T., Buttar, N. S., Iovanna, J., Huebert, R. C. & Lomberk, G., Aug 1 2017, In : Molecular Cancer Research. 15, 8, p. 984-997 14 p.

Research output: Contribution to journalArticle

Aurora Kinase A
Methyltransferases
Epigenomics
Oncogenes
Methylation
6 Citations (Scopus)

Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis

Loarca, L., De Assuncao, T. M., Jalan-Sakrikar, N., Bronk, S., Krishnan, A., Huang, B., Morton, L., Trussoni, C., Bonilla, L. M., Krueger, E., O'Hara, S., Splinter, P., Shi, G., Pisarello, M. J. L., Gores, G. J., Huebert, R. C. & La Russo, N. F., Nov 1 2017, In : Laboratory Investigation. 97, 11, p. 1385-1396 12 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Macrophages
Bile Duct Diseases
Keratin-7
Keratin-19
1 Citation (Scopus)

Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate–Induced Cell Migration

Wang, R., Ding, Q., De Assuncao, T. M., Mounajjed, T., Maiers, J., Dou, C., Cao, S., Yaqoob, U., Huebert, R. C. & Shah, V., Jan 1 2017, In : American Journal of Pathology. 187, 1, p. 134-145 12 p.

Research output: Contribution to journalArticle

Dynamin II
Hepatic Stellate Cells
Sphingosine
GTP Phosphohydrolases
Cell Movement
9 Citations (Scopus)

Regenerative Medicine and the Biliary Tree

De Assuncao, T. M., Jalan-Sakrikar, N. & Huebert, R. C., Feb 1 2017, In : Seminars in Liver Disease. 37, 1, p. 17-27 11 p.

Research output: Contribution to journalArticle

Regenerative Medicine
Biliary Tract
Regeneration
Organoids
Developmental Biology
2016

Black and White Liver

Helmick, R. A., McMenomy, B. P. & Huebert, R. C., Jan 1 2016, In : Clinical Gastroenterology and Hepatology. 14, 1, p. A39-A40

Research output: Contribution to journalArticle

Uveal Neoplasms
MART-1 Antigen
Histocytochemistry
Liver Neoplasms
Radiography
5 Citations (Scopus)

Hedgehog signaling overcomes an EZH2-Dependent epigenetic barrier to promote cholangiocyte expansion

Jalan-Sakrikar, N., De Assuncao, T. M., Lu, J., Almada, L. L., Lomberk, G., Fernandez-Zapico, M. E., Urrutia, R. & Huebert, R. C., Dec 1 2016, In : PLoS One. 11, 12, e0168266.

Research output: Contribution to journalArticle

Hedgehogs
Erinaceidae
Stem cells
Fibronectins
Epigenomics
18 Citations (Scopus)

Notch Signaling Coordinates Progenitor Cell-Mediated Biliary Regeneration Following Partial Hepatectomy

Lu, J., Zhou, Y., Hu, T., Zhang, H., Shen, M., Cheng, P., Dai, W., Wang, F., Chen, K., Zhang, Y., Wang, C., Li, J., Zheng, Y., Yang, J., Zhu, R., Wang, J., Lu, W., Zhang, H., Wang, J., Xia, Y. & 5 others, De Assuncao, T. M., Jalan-Sakrikar, N., Huebert, R. C., Zhou, B. & Guo, C., Mar 8 2016, In : Scientific Reports. 6, 22754.

Research output: Contribution to journalArticle

Hepatectomy
Regeneration
Hepatocytes
Stem Cells
Liver Regeneration
20 Citations (Scopus)

SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma

Merino-Azpitarte, M., Lozano, E., Perugorria, M. J., Esparza-Baquer, A., Erice, O., Santos-Laso, Á., O'Rourke, C. J., Andersen, J. B., Jiménez-Agüero, R., Lacasta, A., D'Amato, M., Briz, Ó., Jalan-Sakrikar, N., Huebert, R. C., Thelen, K. M., Gradilone, S. A., Aransay, A. M., Lavín, J. L., Fernández-Barrena, M. G., Matheu, A. & 5 others, Marzioni, M., Gores, G. J., Bujanda, L., Marin, J. J. G. & Banales, J. M., Aug 28 2016, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Neoplasms
Induced Pluripotent Stem Cells
Down-Regulation
Biomarkers
16 Citations (Scopus)

The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice

Maiers, J., Kostallari, E., Mushref, M., deAssuncao, T. M., Li, H., Jalan-Sakrikar, N., Huebert, R. C., Cao, S., Malhi, H. M. & Shah, V., 2016, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Unfolded Protein Response
Hepatic Stellate Cells
Collagen
Procollagen
Endoplasmic Reticulum
2015
30 Citations (Scopus)

Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes

De Assuncao, T. M., Sun, Y., Jalan-Sakrikar, N., Drinane, M. C., Huang, B. Q., Li, Y., Davila, J. I., Wang, R., O'Hara, S. P., Lomberk, G. A., Urrutia, R. A., Ikeda, Y. H. & Huebert, R. C., Jun 28 2015, In : Laboratory Investigation. 95, 6, p. 684-696 13 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Liver
RNA Sequence Analysis
Endoderm
Calcium Signaling
2 Citations (Scopus)

Erratum: Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes(Laboratory Investigation (2015) 95:(684-696) DOI:10.1038/labinvest.2015.51)

De Assuncao, T. M., Sun, Y., Jalan-Sakrikar, N., Drinane, M. C., Huang, B. Q., Li, Y., Davila, J. I., Wang, R., O'Hara, S. P., Lomberk, G. A., Urrutia, R. A., Ikeda, Y. H. & Huebert, R. C., Oct 1 2015, In : Laboratory Investigation. 95, 10, p. 1218 1 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
51 Citations (Scopus)

Exosome adherence and internalization by hepatic stellate cells triggers sphingosine 1-phosphate-dependent migration

Wang, R., Ding, Q., Yaqoob, U., De Assuncao, T. D. M., Verma, V. K., Hirsova, P., Cao, S., Mukhopadhyay, D., Huebert, R. C. & Shah, V., Dec 25 2015, In : Journal of Biological Chemistry. 290, 52, p. 30684-30696 13 p.

Research output: Contribution to journalArticle

Exosomes
Hepatic Stellate Cells
Endothelial cells
Dynamins
Phosphorylation
2014
39 Citations (Scopus)

Cellular therapy for liver disease

Huebert, R. C. & Rakela, J., 2014, In : Mayo Clinic Proceedings. 89, 3, p. 414-424 11 p.

Research output: Contribution to journalArticle

Liver Diseases
Stem Cells
Regenerative Medicine
Cell- and Tissue-Based Therapy
Transplants
21 Citations (Scopus)

New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids

De Assuncao, T. M., Lomberk, G., Cao, S., Yaqoob, U., Mathison, A., Simonetto, D., Huebert, R. C., Urrutia, R. A. & Shah, V., May 30 2014, In : Journal of Biological Chemistry. 289, 22, p. 15798-15809 12 p.

Research output: Contribution to journalArticle

Kruppel-Like Transcription Factors
Chromatin Assembly and Disassembly
Lipid Metabolism
Chromatin
Genes
6 Citations (Scopus)
Angiopoietin-2
Liver Regeneration
Vascular Endothelium
Hepatocytes
Endothelial Cells
2 Citations (Scopus)

Sinusoidal endothelial cells direct traffic at the intersection of regeneration and fibrosis

Huebert, R. C. & Shah, V., 2014, In : Hepatology. 60, 2, p. 754-756 3 p.

Research output: Contribution to journalArticle

Regeneration
Fibrosis
Endothelial Cells
Liver
Blood Vessels
2012
48 Citations (Scopus)
Receptor, Fibroblast Growth Factor, Type 1
Fibroblast Growth Factor 1
Fibroblast Growth Factor Receptors
Phosphorylation
Endothelial cells
73 Citations (Scopus)

Intestinal decontamination inhibits TLR4 dependent fibronectin-mediated cross-talk between stellate cells and endothelial cells in liver fibrosis in mice

Zhu, Q., Zou, L., Jagavelu, K., Simonetto, D., Huebert, R. C., Jiang, Z. D., Dupont, H. L. & Shah, V., Apr 2012, In : Journal of Hepatology. 56, 4, p. 893-899 7 p.

Research output: Contribution to journalArticle

rifaximin
Toll-Like Receptor 4
Decontamination
Fibronectins
Liver Cirrhosis
2011
36 Citations (Scopus)

Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive MicroRNAs

Huebert, R. C., Jagavelu, K., Hendrickson, H. I., Vasdev, M. M., Arab, J. P., Splinter, P. L., Trussoni, C. E., La Russo, N. F. & Shah, V., Oct 2011, In : American Journal of Pathology. 179, 4, p. 1851-1860 10 p.

Research output: Contribution to journalArticle

Aquaporin 1
Portal Hypertension
MicroRNAs
Fibrosis
Bile Ducts
71 Citations (Scopus)

Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis

Thabut, D., Routray, C., Lomberk, G., Shergill, U., Glaser, K., Huebert, R. C., Patel, L., Masyuk, T., Blechacz, B., Vercnocke, A., Ritman, E., Ehman, R. L., Urrutia, R. & Shah, V., Aug 2011, In : Hepatology. 54, 2, p. 573-585 13 p.

Research output: Contribution to journalArticle

Liver Cirrhosis
Blood Vessels
Hepatic Stellate Cells
Liver
Paracrine Communication
2010
38 Citations (Scopus)

Aquaporin-1 facilitates angiogenic invasion in the pathological neovasculature that accompanies cirrhosis

Huebert, R. C., Vasdev, M. M., Shergill, U., Das, A., Huang, B. Q., Charlton, M. R., La Russo, N. F. & Shah, V., Jul 2010, In : Hepatology. 52, 1, p. 238-248 11 p.

Research output: Contribution to journalArticle

Aquaporin 1
Fibrosis
Blister
Liver
Endothelial Cells
37 Citations (Scopus)

Immortalized liver endothelial cells: A cell culture model for studies of motility and angiogenesis

Huebert, R. C., Jagavelu, K., Liebl, A. F., Huang, B. Q., Splinter, P. L., La Russo, N. F., Urrutia, R. A. & Shah, V., Dec 2010, In : Laboratory Investigation. 90, 12, p. 1770-1781 12 p.

Research output: Contribution to journalArticle

Endothelial Cells
Cell Culture Techniques
Liver
Pseudopodia
Endocytosis
97 Citations (Scopus)

Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells

Cao, S., Yaqoob, U., Das, A., Shergill, U., Jagavelu, K., Huebert, R. C., Routray, C., Abdelmoneim, S., Vasdev, M., Leof, E. B., Charlton, M., Watts, R. J., Mukhopadhyay, D. & Shah, V., Jul 1 2010, In : Journal of Clinical Investigation. 120, 7, p. 2379-2394 16 p.

Research output: Contribution to journalArticle

Neuropilin-1
Hepatic Stellate Cells
Rodentia
Fibrosis
Liver Cirrhosis
1 Citation (Scopus)

Targeted Sprouty1 overexpression in cardiac myocytes does not alter myocardial remodeling or function

Charles, N. J., Huebert, R. C., Lee, S., Adhikari, N., Polster, S., Rider, J. E., Braunlin, E., Mariash, A., Robledo, M., Schuweiler, D. & Hall, J. L., Sep 2010, In : Molecular and Cellular Biochemistry. 342, 1-2, p. 57-62 6 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Mitogen-Activated Protein Kinases
Tissue
Ventricular Myosins
Up-Regulation
2006
76 Citations (Scopus)

T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis

Allina, J., Hu, B., Sullivan, D. M., Fiel, M. I., Thung, S. N., Bronk, S. F., Huebert, R. C., van de Water, J., La Russo, N. F., Gershwin, M. E., Gores, G. J. & Odin, J. A., Dec 2006, In : Journal of Autoimmunity. 27, 4, p. 232-241 10 p.

Research output: Contribution to journalArticle

Cytophagocytosis
Biliary Liver Cirrhosis
Autoantigens
Epithelial Cells
Phagocytosis
2004
10 Citations (Scopus)

Differential expression of cholangiocyte and ileal bile acid transporters following bile acid supplementation and depletion

Kip, N. S., Lazaridis, K. N., Masyuk, A. I., Splinter, P. L., Huebert, R. C. & La Russo, N. F., May 15 2004, In : World Journal of Gastroenterology. 10, 10, p. 1440-1446 7 p.

Research output: Contribution to journalArticle

Taurocholic Acid
Bile Acids and Salts
Cholestyramine Resin
Diet
Intrahepatic Bile Ducts
24 Citations (Scopus)

Identification and regulation of Sprouty1, a negative inhibitor of the ERK cascade, in the human heart

Huebert, R. C., Li, Q., Adhikari, N., Charles, N. J., Han, X., Ezzat, M. K., Grindle, S., Park, S., Ormaza, S., Fermin, D., Miller, L. W. & Hall, J. L., Oct 2004, In : Physiological Genomics. 18, p. 284-289 6 p.

Research output: Contribution to journalArticle

Heart-Assist Devices
Up-Regulation
Endothelial Cells
Ventricular Remodeling
ras Genes
2003
70 Citations (Scopus)

Glucagon induces the plasma membrane insertion of functional aquaporin-8 water channels in isolated rat hepatocytes

Gradilone, S. A., García, F., Huebert, R. C., Tietz, P. S., Larocca, M. C., Kierbel, A., Carreras, F. I., La Russo, N. F. & Marinelli, R. A., Jun 1 2003, In : Hepatology. 37, 6, p. 1435-1441 7 p.

Research output: Contribution to journalArticle

Aquaporins
Glucagon
Hepatocytes
Cell Membrane
Permeability
51 Citations (Scopus)

Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes

Gong, A. Y., Tietz, P. S., Muff, M. A., Splinter, P. L., Huebert, R. C., Strowski, M. Z., Chen, X. M. & La Russo, N. F., May 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 5 53-5

Research output: Contribution to journalArticle

Somatostatin
Intrahepatic Bile Ducts
Bile
Ducts
Secretin
2002
19 Citations (Scopus)

Channel-mediated water movement across enclosed or perfused mouse intrahepatic bile duct units

Gong, A. Y., Masyuk, A. I., Splinter, P. L., Huebert, R. C., Tietz, P. S. & La Russo, N. F., 2002, In : American Journal of Physiology - Cell Physiology. 283, 1 52-1

Research output: Contribution to journalArticle

Water Movements
Intrahepatic Bile Ducts
Ducts
Water
Aquaporins
8 Citations (Scopus)

Experimental models to study cholangiocyte biology

Tietz, P. S., Chen, X. M., Gong, A. Y., Huebert, R. C., Masyuk, A., Masyuk, T., Splinter, P. L. & La Russo, N. F., 2002, In : World Journal of Gastroenterology. 8, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

Bile Ducts
Theoretical Models
Cryptosporidium parvum
Biliary Tract
Bile
119 Citations (Scopus)

Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion

Huebert, R. C., Splinter, P. L., Garcia, F., Marinelli, R. A. & La Russo, N. F., Jun 21 2002, In : Journal of Biological Chemistry. 277, 25, p. 22710-22717 8 p.

Research output: Contribution to journalArticle

Aquaporins
Bile
Rats
Hepatocytes
Cell membranes
2001
175 Citations (Scopus)

Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis

Odin, J. A., Huebert, R. C., Casciola-Rosen, L., La Russo, N. F. & Rosen, A., 2001, In : Journal of Clinical Investigation. 108, 2, p. 223-232 10 p.

Research output: Contribution to journalArticle

Biliary Liver Cirrhosis
Autoantigens
Pyruvic Acid
Oxidoreductases
Autoantibodies