• 1272 Citations
  • 19 Scopus h-Index
20012019

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

  • 1272 Citations
  • 19 Scopus h-Index
  • 38 Article
  • 3 Chapter
  • 2 Comment/debate
  • 1 Review article
2019

3D printing for bio-synthetic biliary stents

Boyer, C. J., Boktor, M., Samant, H., White, L. A., Wang, Y., Ballard, D. H., Huebert, R. C., Woerner, J. E., Ghali, G. E. & Alexander, J. S., Jan 1 2019, In : Bioengineering. 6, 1, 16.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Author Correction: Sustained perfusion of revascularized bioengineered livers heterotopically transplanted into immunosuppressed pigs (Nature Biomedical Engineering, (2019), 10.1038/s41551-019-0460-x)

Shaheen, M. F., Joo, D. J., Ross, J. J., Anderson, B. D., Chen, H. S., Huebert, R. C., Li, Y., Amiot, B., Young, A., Zlochiver, V., Nelson, E., Mounajjed, T., Dietz, A. B., Michalak, G., Steiner, B. G., Davidow, D. S., Paradise, C. R., van Wijnen, A. J., Shah, V. H., Liu, M. & 1 others, Nyberg, S. L., Jan 1 2019, (Accepted/In press) In : Nature Biomedical Engineering.

Research output: Contribution to journalComment/debate

Open Access

Cholangiocyte pathobiology

Banales, J. M., Huebert, R. C., Karlsen, T., Strazzabosco, M., La Russo, N. F. & Gores, G. J., Jan 1 2019, In : Nature Reviews Gastroenterology and Hepatology.

Research output: Contribution to journalReview article

8 Scopus citations

Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis

Martin-Mateos, R., De Assuncao, T. M., Arab, J. P., Jalan-Sakrikar, N., Yaqoob, U., Greuter, T., Verma, V. K., Mathison, A. J., Cao, S., Lomberk, G., Mathurin, P., Urrutia, R., Huebert, R. C. & Shah, V., Jan 1 2019, In : CMGH. 7, 1, p. 197-209 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Proteasomal Degradation of Enhancer of Zeste Homologue 2 in Cholangiocytes Promotes Biliary Fibrosis

Jalan-Sakrikar, N., De Assuncao, T. M., Shi, G., Aseem, S. O., Chi, C., Shah, V. & Huebert, R. C., Jan 1 2019, In : Hepatology.

Research output: Contribution to journalArticle

1 Scopus citations

Sustained perfusion of revascularized bioengineered livers heterotopically transplanted into immunosuppressed pigs

Shaheen, M. F., Joo, D. J., Ross, J. J., Anderson, B. D., Chen, H. S., Huebert, R. C., Li, Y., Amiot, B., Young, A., Zlochiver, V., Nelson, E., Mounajjed, T., Dietz, A. B., Michalak, G., Steiner, B. G., Davidow, D. S., Paradise, C. R., van Wijnen, A. J., Shah, V. H., Liu, M. & 1 others, Nyberg, S. L., Jan 1 2019, (Accepted/In press) In : Nature Biomedical Engineering.

Research output: Contribution to journalArticle

1 Scopus citations
2018

Ducts in a dish: Bioengineered biliary scaffolds for regenerative medicine

Jalan-Sakrikar, N. & Huebert, R. C., Apr 1 2018, In : Hepatology. 67, 4, p. 1622-1624 3 p.

Research output: Contribution to journalComment/debate

Epigenetics of gastrointestinal diseases: notes from a workshop

Marks, D. L., Olson, R. L., Urrutia, R., Billadeau, D. D., Roy, N., Calin, G. A., Fabbri, M., Koutsioumpa, M., Iliopoulos, D., Ordog, T., Huebert, R. C., Sarmento, O., Bamidele, A. O., Faubion, W. A., Lomberk, G. L., Siveke, J., Ahuja, N., Iovanna, J., Hlady, R. A., Robertson, K. D. & 3 others, Kisiel, J. B., Pin, C. L. & Fernandez-Zapico, M. E., Apr 3 2018, In : Epigenetics. 13, 4, p. 449-457 9 p.

Research output: Contribution to journalArticle

2017

Combined AURKA and H3K9 methyltransferase targeting inhibits cell growth by inducing mitotic catastrophe

Mathison, A., Salmonson, A., Missfeldt, M., Bintz, J., Williams, M., Kossak, S., Nair, A., De Assuncao, T. M., Christensen, T., Buttar, N. S., Iovanna, J., Huebert, R. C. & Lomberk, G., Aug 1 2017, In : Molecular Cancer Research. 15, 8, p. 984-997 14 p.

Research output: Contribution to journalArticle

6 Scopus citations

Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis

Loarca, L., De Assuncao, T. M., Jalan-Sakrikar, N., Bronk, S., Krishnan, A., Huang, B., Morton, L., Trussoni, C., Bonilla, L. M., Krueger, E., O'Hara, S., Splinter, P., Shi, G., Pisarello, M. J. L., Gores, G. J., Huebert, R. C. & La Russo, N. F., Nov 1 2017, In : Laboratory Investigation. 97, 11, p. 1385-1396 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate–Induced Cell Migration

Wang, R., Ding, Q., De Assuncao, T. M., Mounajjed, T., Maiers, J., Dou, C., Cao, S., Yaqoob, U., Huebert, R. C. & Shah, V., Jan 1 2017, In : American Journal of Pathology. 187, 1, p. 134-145 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Regenerative Medicine and the Biliary Tree

De Assuncao, T. M., Jalan-Sakrikar, N. & Huebert, R. C., Feb 1 2017, In : Seminars in Liver Disease. 37, 1, p. 17-27 11 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Black and White Liver

Helmick, R. A., McMenomy, B. P. & Huebert, R. C., Jan 1 2016, In : Clinical Gastroenterology and Hepatology. 14, 1, p. A39-A40

Research output: Contribution to journalArticle

Hedgehog signaling overcomes an EZH2-Dependent epigenetic barrier to promote cholangiocyte expansion

Jalan-Sakrikar, N., De Assuncao, T. M., Lu, J., Almada, L. L., Lomberk, G., Fernandez-Zapico, M. E., Urrutia, R. & Huebert, R. C., Dec 1 2016, In : PLoS One. 11, 12, e0168266.

Research output: Contribution to journalArticle

6 Scopus citations

Notch Signaling Coordinates Progenitor Cell-Mediated Biliary Regeneration Following Partial Hepatectomy

Lu, J., Zhou, Y., Hu, T., Zhang, H., Shen, M., Cheng, P., Dai, W., Wang, F., Chen, K., Zhang, Y., Wang, C., Li, J., Zheng, Y., Yang, J., Zhu, R., Wang, J., Lu, W., Zhang, H., Wang, J., Xia, Y. & 5 others, De Assuncao, T. M., Jalan-Sakrikar, N., Huebert, R. C., Zhou, B. & Guo, C., Mar 8 2016, In : Scientific Reports. 6, 22754.

Research output: Contribution to journalArticle

22 Scopus citations

SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma

Merino-Azpitarte, M., Lozano, E., Perugorria, M. J., Esparza-Baquer, A., Erice, O., Santos-Laso, Á., O'Rourke, C. J., Andersen, J. B., Jiménez-Agüero, R., Lacasta, A., D'Amato, M., Briz, Ó., Jalan-Sakrikar, N., Huebert, R. C., Thelen, K. M., Gradilone, S. A., Aransay, A. M., Lavín, J. L., Fernández-Barrena, M. G., Matheu, A. & 5 others, Marzioni, M., Gores, G. J., Bujanda, L., Marin, J. J. G. & Banales, J. M., Aug 28 2016, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

23 Scopus citations

The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice

Maiers, J., Kostallari, E., Mushref, M., deAssuncao, T. M., Li, H., Jalan-Sakrikar, N., Huebert, R. C., Cao, S., Malhi, H. M. & Shah, V., 2016, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

18 Scopus citations
2015

Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes

De Assuncao, T. M., Sun, Y., Jalan-Sakrikar, N., Drinane, M. C., Huang, B. Q., Li, Y., Davila, J. I., Wang, R., O'Hara, S. P., Lomberk, G. A., Urrutia, R. A., Ikeda, Y. H. & Huebert, R. C., Jun 28 2015, In : Laboratory Investigation. 95, 6, p. 684-696 13 p.

Research output: Contribution to journalArticle

33 Scopus citations

Erratum: Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes(Laboratory Investigation (2015) 95:(684-696) DOI:10.1038/labinvest.2015.51)

De Assuncao, T. M., Sun, Y., Jalan-Sakrikar, N., Drinane, M. C., Huang, B. Q., Li, Y., Davila, J. I., Wang, R., O'Hara, S. P., Lomberk, G. A., Urrutia, R. A., Ikeda, Y. H. & Huebert, R. C., Oct 1 2015, In : Laboratory Investigation. 95, 10, p. 1218 1 p.

Research output: Contribution to journalArticle

2 Scopus citations

Exosome adherence and internalization by hepatic stellate cells triggers sphingosine 1-phosphate-dependent migration

Wang, R., Ding, Q., Yaqoob, U., De Assuncao, T. D. M., Verma, V. K., Hirsova, P., Cao, S., Mukhopadhyay, D., Huebert, R. C. & Shah, V., Dec 25 2015, In : Journal of Biological Chemistry. 290, 52, p. 30684-30696 13 p.

Research output: Contribution to journalArticle

61 Scopus citations

Hepatic sinusoidal endothelial cells

Hilscher, M. B., Huebert, R. C. & Shah, V., Sep 28 2015, Signaling Pathways in Liver Diseases: Third Edition. Wiley Blackwell, p. 73-84 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations
2014

Cellular therapy for liver disease

Huebert, R. C. & Rakela, J., 2014, In : Mayo Clinic Proceedings. 89, 3, p. 414-424 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids

De Assuncao, T. M., Lomberk, G., Cao, S., Yaqoob, U., Mathison, A., Simonetto, D., Huebert, R. C., Urrutia, R. A. & Shah, V., May 30 2014, In : Journal of Biological Chemistry. 289, 22, p. 15798-15809 12 p.

Research output: Contribution to journalArticle

27 Scopus citations
8 Scopus citations

Sinusoidal endothelial cells direct traffic at the intersection of regeneration and fibrosis

Huebert, R. C. & Shah, V., 2014, In : Hepatology. 60, 2, p. 754-756 3 p.

Research output: Contribution to journalArticle

3 Scopus citations
2013

Natural history of recurrent hepatitis C: Impact of immunosuppression

Huebert, R. C. & Watt, K. D., Jul 1 2013, Hepatitis C Virus and Liver Transplantation. Springer New York, p. 29-43 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2012
49 Scopus citations

Intestinal decontamination inhibits TLR4 dependent fibronectin-mediated cross-talk between stellate cells and endothelial cells in liver fibrosis in mice

Zhu, Q., Zou, L., Jagavelu, K., Simonetto, D., Huebert, R. C., Jiang, Z. D., Dupont, H. L. & Shah, V., Apr 2012, In : Journal of Hepatology. 56, 4, p. 893-899 7 p.

Research output: Contribution to journalArticle

78 Scopus citations
2011

Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive MicroRNAs

Huebert, R. C., Jagavelu, K., Hendrickson, H. I., Vasdev, M. M., Arab, J. P., Splinter, P. L., Trussoni, C. E., La Russo, N. F. & Shah, V., Oct 2011, In : American Journal of Pathology. 179, 4, p. 1851-1860 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis

Thabut, D., Routray, C., Lomberk, G., Shergill, U., Glaser, K., Huebert, R. C., Patel, L., Masyuk, T., Blechacz, B., Vercnocke, A., Ritman, E., Ehman, R. L., Urrutia, R. & Shah, V., Aug 2011, In : Hepatology. 54, 2, p. 573-585 13 p.

Research output: Contribution to journalArticle

73 Scopus citations
2010

Aquaporin-1 facilitates angiogenic invasion in the pathological neovasculature that accompanies cirrhosis

Huebert, R. C., Vasdev, M. M., Shergill, U., Das, A., Huang, B. Q., Charlton, M. R., La Russo, N. F. & Shah, V., Jul 2010, In : Hepatology. 52, 1, p. 238-248 11 p.

Research output: Contribution to journalArticle

38 Scopus citations

Hepatic sinusoidal endothelial cells

Huebert, R. C. & Shah, V., 2010, Signaling Pathways in Liver Diseases. Springer Berlin Heidelberg, p. 79-91 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Immortalized liver endothelial cells: A cell culture model for studies of motility and angiogenesis

Huebert, R. C., Jagavelu, K., Liebl, A. F., Huang, B. Q., Splinter, P. L., La Russo, N. F., Urrutia, R. A. & Shah, V., Dec 2010, In : Laboratory Investigation. 90, 12, p. 1770-1781 12 p.

Research output: Contribution to journalArticle

39 Scopus citations

Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells

Cao, S., Yaqoob, U., Das, A., Shergill, U., Jagavelu, K., Huebert, R. C., Routray, C., Abdelmoneim, S., Vasdev, M., Leof, E. B., Charlton, M., Watts, R. J., Mukhopadhyay, D. & Shah, V., Jul 1 2010, In : Journal of Clinical Investigation. 120, 7, p. 2379-2394 16 p.

Research output: Contribution to journalArticle

99 Scopus citations

Targeted Sprouty1 overexpression in cardiac myocytes does not alter myocardial remodeling or function

Charles, N. J., Huebert, R. C., Lee, S., Adhikari, N., Polster, S., Rider, J. E., Braunlin, E., Mariash, A., Robledo, M., Schuweiler, D. & Hall, J. L., Sep 2010, In : Molecular and Cellular Biochemistry. 342, 1-2, p. 57-62 6 p.

Research output: Contribution to journalArticle

1 Scopus citations
2006

T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis

Allina, J., Hu, B., Sullivan, D. M., Fiel, M. I., Thung, S. N., Bronk, S. F., Huebert, R. C., van de Water, J., La Russo, N. F., Gershwin, M. E., Gores, G. J. & Odin, J. A., Dec 2006, In : Journal of Autoimmunity. 27, 4, p. 232-241 10 p.

Research output: Contribution to journalArticle

77 Scopus citations
2004

Differential expression of cholangiocyte and ileal bile acid transporters following bile acid supplementation and depletion

Kip, N. S., Lazaridis, K. N., Masyuk, A. I., Splinter, P. L., Huebert, R. C. & La Russo, N. F., May 15 2004, In : World Journal of Gastroenterology. 10, 10, p. 1440-1446 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Identification and regulation of Sprouty1, a negative inhibitor of the ERK cascade, in the human heart

Huebert, R. C., Li, Q., Adhikari, N., Charles, N. J., Han, X., Ezzat, M. K., Grindle, S., Park, S., Ormaza, S., Fermin, D., Miller, L. W. & Hall, J. L., Oct 2004, In : Physiological Genomics. 18, p. 284-289 6 p.

Research output: Contribution to journalArticle

24 Scopus citations
2003

Glucagon induces the plasma membrane insertion of functional aquaporin-8 water channels in isolated rat hepatocytes

Gradilone, S. A., García, F., Huebert, R. C., Tietz, P. S., Larocca, M. C., Kierbel, A., Carreras, F. I., La Russo, N. F. & Marinelli, R. A., Jun 1 2003, In : Hepatology. 37, 6, p. 1435-1441 7 p.

Research output: Contribution to journalArticle

72 Scopus citations

Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes

Gong, A. Y., Tietz, P. S., Muff, M. A., Splinter, P. L., Huebert, R. C., Strowski, M. Z., Chen, X. M. & La Russo, N. F., May 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 5 53-5

Research output: Contribution to journalArticle

52 Scopus citations
2002

Channel-mediated water movement across enclosed or perfused mouse intrahepatic bile duct units

Gong, A. Y., Masyuk, A. I., Splinter, P. L., Huebert, R. C., Tietz, P. S. & La Russo, N. F., 2002, In : American Journal of Physiology - Cell Physiology. 283, 1 52-1

Research output: Contribution to journalArticle

19 Scopus citations

Experimental models to study cholangiocyte biology

Tietz, P. S., Chen, X. M., Gong, A. Y., Huebert, R. C., Masyuk, A., Masyuk, T., Splinter, P. L. & La Russo, N. F., 2002, In : World Journal of Gastroenterology. 8, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion

Huebert, R. C., Splinter, P. L., Garcia, F., Marinelli, R. A. & La Russo, N. F., Jun 21 2002, In : Journal of Biological Chemistry. 277, 25, p. 22710-22717 8 p.

Research output: Contribution to journalArticle

121 Scopus citations
2001

Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis

Odin, J. A., Huebert, R. C., Casciola-Rosen, L., La Russo, N. F. & Rosen, A., 2001, In : Journal of Clinical Investigation. 108, 2, p. 223-232 10 p.

Research output: Contribution to journalArticle

176 Scopus citations