Rajiv Kumar, M.B., B.S., M.A.C.P.

  • 14437 Citations
  • 62 Scopus h-Index
1975 …2019

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2019

Clinical and Biochemical Phenotypes in a Family With ENPP1 Mutations

Kotwal, A., Ferrer, A., Kumar, R., Singh, R. J., Murthy, V., Schultz-Rogers, L., Zimmermann, M., Lanpher, B., Zimmerman, K., Stabach, P. R., Klee, E., Braddock, D. T. & Wermers, R. A., Jan 1 2019, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

Impaired cardiac performance, protein synthesis, and mitochondrial function in tumor-bearing mice

Berent, T. E., Dorschner, J. M., Meyer, T., Craig, T. A., Wang, X., Kunz, H., Jatoi, A., Lanza, I. R., Chen, H. & Kumar, R., Jan 1 2019, In : PloS one. 14, 12, e0226440.

Research output: Contribution to journalArticle

Open Access

Lung tumor cells inhibit bone mineralization and osteoblast activity

Berent, T. E., Dorschner, J. M., Craig, T. A., Drake, M. M., Westendorf, J. J. & Kumar, R., Jan 1 2019, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

1 Scopus citations
2018

1α,25-dihydroxyvitamin D3 mitigates cancer cell mediated mitochondrial dysfunction in human skeletal muscle cells

Ryan, Z. C., Craig, T. A., Wang, X., Delmotte, P., Salisbury, J. L., Lanza, I. R., Sieck, G. C. & Kumar, R., Feb 5 2018, In : Biochemical and Biophysical Research Communications. 496, 2, p. 746-752 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Comparison of the effect of daily versus bolus dose maternal vitamin D3 supplementation on the 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 ratio

Ketha, H., Thacher, T. D., Oberhelman, S. S., Fischer, P. R., Singh, R. J. & Kumar, R., May 1 2018, In : Bone. 110, p. 321-325 5 p.

Research output: Contribution to journalArticle

5 Scopus citations
2017

Hydrogen-Deuterium Exchange Mass Spectrometry Reveals Calcium Binding Properties and Allosteric Regulation of Downstream Regulatory Element Antagonist Modulator (DREAM)

Zhang, J., Li, J., Craig, T. A., Kumar, R. & Gross, M. L., Jul 18 2017, In : Biochemistry. 56, 28, p. 3523-3530 8 p.

Research output: Contribution to journalArticle

1 Scopus citations
6 Scopus citations
2016

1α,25-dihydroxyvitamin D3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells

Ryan, Z. C., Craig, T. A., Folmes, C., Wang, X., Lanza, I. R., Schaible, N. S., Salisbury, J. L., Nair, K. S., Terzic, A., Sieck, G. C. & Kumar, R., Jan 15 2016, In : Journal of Biological Chemistry. 291, 3, p. 1514-1528 15 p., 15.

Research output: Contribution to journalArticle

54 Scopus citations

Abnormalities in biomarkers of mineral and bone metabolism in kidney donors

Kasiske, B. L., Kumar, R., Kimmel, P. L., Pesavento, T. E., Kalil, R. S., Kraus, E. S., Rabb, H., Posselt, A. M., Anderson-Haag, T. L., Steffes, M. W., Israni, A. K., Snyder, J. J., Singh, R. J. & Weir, M. R., Mar 9 2016, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

5 Scopus citations

Calciphylaxis: A Disease of Pannicular Thrombosis

el-Azhary, R. A., Patzelt, M. T., McBane, R. D., Weaver, A. L., Albright, R. C., Bridges, A. D., Claus, P. L., Davis, M. D. P., Dillon, J. J., El-Zoghby, Z. M., Hickson, L., Kumar, R., McCarthy-Fruin, K. A. M., McEvoy, M. T., Pittelkow, M. R., Wetter, D. A., Williams, A. W. & McCarthy, J. T., Oct 1 2016, In : Mayo Clinic Proceedings. 91, 10, p. 1395-1402 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Clinical and biochemical phenotypes of adults with monoallelic and biallelic CYP24A1 mutations: evidence of gene dose effect

O’Keeffe, D. T., Tebben, P., Kumar, R., Singh, R. J., Wu, Y. & Wermers, R. A., Apr 29 2016, (Accepted/In press) In : Osteoporosis International. p. 1-5 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

LC-MS/MS for identifying patients with CYP24A1 mutations

Ketha, H., Kumar, R. & Singh, R. J., Jan 2016, In : Clinical chemistry. 62, 1, p. 236-242 7 p.

Research output: Contribution to journalArticle

29 Scopus citations

Survival, Risk Factors, and Effect of Treatment in 101 Patients With Calciphylaxis

McCarthy, J. T., el-Azhary, R. A., Patzelt, M. T., Weaver, A. L., Albright, R. C., Bridges, A. D., Claus, P. L., Davis, M. D. P., Dillon, J. J., El-Zoghby, Z. M., Hickson, L., Kumar, R., McBane, R. D., McCarthy-Fruin, K. A. M., McEvoy, M. T., Pittelkow, M. R., Wetter, D. A. & Williams, A. W., Oct 1 2016, In : Mayo Clinic Proceedings. 91, 10, p. 1384-1394 11 p.

Research output: Contribution to journalArticle

43 Scopus citations
2015

Altered calcium and Vitamin D homeostasis in first-time calcium kidney stone-formers

Ketha, H., Singh, R. J., Grebe, S. K., Bergstralh, E. J., Rule, A. D., Lieske, J. C. & Kumar, R., Sep 2 2015, In : PLoS One. 10, 9, e0137350.

Research output: Contribution to journalArticle

16 Scopus citations

A prospective controlled study of living kidney donors: Three-year follow-up

Kasiske, B. L., Anderson-Haag, T., Israni, A. K., Kalil, R. S., Kimmel, P. L., Kraus, E. S., Kumar, R., Posselt, A. A., Pesavento, T. E., Rabb, H., Steffes, M. W., Snyder, J. J. & Weir, M. R., Jul 1 2015, In : American Journal of Kidney Diseases. 66, 1, p. 114-124 11 p.

Research output: Contribution to journalArticle

65 Scopus citations

Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3

Ryan, Z. C., Craig, T. A., Filoteo, A. G., Westendorf, J. J., Cartwright, E. J., Neyses, L., Strehler, E. E. & Kumar, R., Nov 6 2015, In : Biochemical and Biophysical Research Communications. 467, 1, p. 152-156 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Follicular lymphoma presenting with hypercalcaemia: An unusual mechanism of hypercalcaemia

Martens, P., Addissie, B. & Kumar, R., Jun 1 2015, In : Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine. 70, 3, p. 200-203 4 p.

Research output: Contribution to journalArticle

2 Scopus citations
1 Scopus citations
2014

Detection of 1α,25-dihydroxyvitamin D-regulated miRNAs in zebrafish by whole transcriptome sequencing

Craig, T. A., Zhang, Y., Magis, A. T., Funk, C. C., Price, N. D., Ekker, S. C. & Kumar, R., Jun 1 2014, In : Zebrafish. 11, 3, p. 207-218 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Enhanced prostacyclin formation and Wnt signaling in sclerostin deficient osteocytes and bone

Ryan, Z. C., Craig, T. A., Salisbury, J. L., Carpio, L. R., McGee-Lawrence, M., Westendorf, J. J. & Kumar, R., May 23 2014, In : Biochemical and Biophysical Research Communications. 448, 1, p. 83-88 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

The role of Iex-1 in the pathogenesis of venous neointimal hyperplasia associated with hemodialysis arteriovenous fistula

Brahmbhatt, A., NievesTorres, E., Yang, B., Edwards, W. D., Chaudhury, P. R., Lee, M. K., Kong, H., Mukhopadhyay, D., Kumar, R. & Misra, S., Jul 18 2014, In : PloS one. 9, 7, e102542.

Research output: Contribution to journalArticle

13 Scopus citations

Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-kB pathways and their target, IEX-1

De Laval, B., Pawlikowska, P., Barbieri, D., Besnard-Guerin, C., Cico, A., Kumar, R., Gaudry, M., Baud, V. & Porteu, F., Jan 23 2014, In : Blood. 123, 4, p. 509-519 11 p.

Research output: Contribution to journalArticle

26 Scopus citations
2013

Characterization of the effect of chronic administration of a calcium-sensing receptor antagonist, ronacaleret, on renal calcium excretion and serum calcium in postmenopausal women

Caltabiano, S., Dollery, C. T., Hossain, M., Kurtinecz, M. T., Desjardins, J. P., Favus, M. J., Kumar, R. & Fitzpatrick, L. A., Sep 1 2013, In : Bone. 56, 1, p. 154-162 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

H/D exchange centroid monitoring is insufficient to show differences in the behavior of protein states

Zhang, J., Ramachandran, P., Kumar, R. & Gross, M. L., Mar 1 2013, In : Journal of the American Society for Mass Spectrometry. 24, 3, p. 450-453 4 p.

Research output: Contribution to journalArticle

22 Scopus citations

Histone deacetylase 3 is required for maintenance of bone mass during aging

McGee-Lawrence, M. E., Bradley, E. W., Dudakovic, A., Carlson, S. W., Ryan, Z. C., Kumar, R., Dadsetan, M., Yaszemski, M. J., Chen, Q., An, K. N. & Westendorf, J. J., Jan 1 2013, In : Bone. 52, 1, p. 296-307 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Oral paricalcitol reduces the prevalence of posttransplant hyperparathyroidism: Results of an open label randomized trial

Amer, H., Griffin, M. D., Stegall, M. D., Cosio, F. G., Park, W. D., Kremers, W. K., Heilman, R. L., Mazur, M. J., Hamawi, K., Larson, T. S. & Kumar, R., Jun 1 2013, In : American Journal of Transplantation. 13, 6, p. 1576-1585 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Osteocalcin and the regulation of glucose metabolism

Vella, A. & Kumar, R., Mar 1 2013, In : Clinical Reviews in Bone and Mineral Metabolism. 11, 1, p. 11-16 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium

Ryan, Z. C., Ketha, H., McNulty, M. S., McGee-Lawrence, M., Craig, T. A., Grande, J. P., Westendorf, J. J., Singh, R. J. & Kumar, R., Apr 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 15, p. 6199-6204 6 p.

Research output: Contribution to journalArticle

71 Scopus citations

Sclerostin deficient mice rapidly heal bone defects by activating β-catenin and increasing intramembranous ossification

McGee-Lawrence, M. E., Ryan, Z. C., Carpio, L. R., Kakar, S., Westendorf, J. J. & Kumar, R., Nov 29 2013, In : Biochemical and Biophysical Research Communications. 441, 4, p. 886-890 5 p.

Research output: Contribution to journalArticle

29 Scopus citations
7 Scopus citations
10 Scopus citations
2012

Expression of sclerostin in the developing zebrafish (Danio rerio) brain and skeleton

McNulty, M. S., Bedell, V. M., Greenwood, T. M., Craig, T. A., Ekker, S. C. & Kumar, R., Aug 1 2012, In : Gene Expression Patterns. 12, 7-8, p. 228-235 8 p.

Research output: Contribution to journalArticle

7 Scopus citations

Hydrogen/deuterium exchange reflects binding of human centrin 2 to Ca 2+ and Xeroderma pigmentosum Group C peptide: An example of EX1 kinetics

Sperry, J. B., Ryan, Z. C., Kumar, R. & Gross, M. L., Dec 15 2012, In : International Journal of Mass Spectrometry. 330-332, p. 302-309 8 p.

Research output: Contribution to journalArticle

3 Scopus citations
94 Scopus citations

The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function

Ramachandran, P. L., Craig, T. A., Atanasova, E. A., Cui, G., Owen, B. A., Bergen, H. R., Mer, G. & Kumar, R., Nov 16 2012, In : Journal of Biological Chemistry. 287, 47, p. 39439-39448 10 p.

Research output: Contribution to journalArticle

Open Access
12 Scopus citations

The sclerostin-bone protein interactome

Devarajan-Ketha, H., Craig, T. A., Madden, B. J., Robert Bergen, H. & Kumar, R., Jan 13 2012, In : Biochemical and Biophysical Research Communications. 417, 2, p. 830-835 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Whole transcriptome RNA sequencing detects multiple 1α 25- dihydroxyvitamin D3-sensitive metabolic pathways in developing zebrafish

Craig, T. A., Zhang, Y., McNulty, M. S., Middha, S., Ketha, H., Singh, R. J., Magis, A. T., Funk, C., Price, N. D., Ekker, S. C. & Kumar, R., Sep 1 2012, In : Molecular Endocrinology. 26, 9, p. 1630-1642 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2011

Determination of serum and plasma sclerostin concentrations by enzyme-linked immunoassays

McNulty, M., Singh, R. J., Li, X., Bergstralh, E. J. & Kumar, R., Jul 1 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 7, p. E1159-E1162

Research output: Contribution to journalArticle

47 Scopus citations

Fat malabsorption and increased intestinal oxalate absorption are common after roux-en-Y gastric bypass surgery

Kumar, R., Lieske, J. C., Collazo-Clavell, M. L., Sarr, M. G., Olson, E. R., Vrtiska, T. J., Bergstralh, E. J. & Li, X., May 1 2011, In : Surgery. 149, 5, p. 654-661 8 p.

Research output: Contribution to journalArticle

98 Scopus citations

Serum 25-hydroxyvitamin D is associated with enhanced pneumococcal antibody levels in individuals with asthma

Lee, J., Zhao, H., Fenta, Y., Kita, H., Kumar, R. & Juhn, Y. J., Nov 1 2011, In : Allergy and Asthma Proceedings. 32, 6, p. 445-452 8 p.

Research output: Contribution to journalArticle

7 Scopus citations
2010

Ablation of Gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: Role for gly96/iex-1 in the regulation of NF-kB

Sina, C., Arlt, A., Gavrilova, O., Midtling, E., Kruse, M. L., Müerköster, S. S., Kumar, R., Fölsch, U. R., Schreiber, S., Rosenstiel, P. & Schäfer, H., Jan 18 2010, In : Inflammatory bowel diseases. 16, 2, p. 320-331 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response

Pawlikowska, P., Leray, I., De Laval, B., Guihard, S., Kumar, R., Rosselli, F. & Porteu, F., Nov 1 2010, In : Cell Death and Differentiation. 17, 11, p. 1739-1750 12 p.

Research output: Contribution to journalArticle

42 Scopus citations

Coordination of centrosome homeostasis and DNA repair is intact in MCF-7 and disrupted in MDA-MB 231 breast cancer cells

Acu, I. D., Liu, T., Suino-Powell, K., Mooney, S. M., D'Assoro, A. B., Rowland, N., Muotri, A. R., Correa, R. G., Niu, Y., Kumar, R. & Salisbury, J. L., Apr 15 2010, In : Cancer research. 70, 8, p. 3320-3328 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Effect of phylloquinone supplementation on glucose homeostasis in humans

Kumar, R., Binkley, N. & Vella, A., Dec 1 2010, In : American Journal of Clinical Nutrition. 92, 6, p. 1528-1532 5 p.

Research output: Contribution to journalArticle

36 Scopus citations

Sclerostin binds and regulates the activity of cysteine-rich protein 61

Craig, T. A., Bhattacharya, R., Mukhopadhyay, D. & Kumar, R., Jan 29 2010, In : Biochemical and Biophysical Research Communications. 392, 1, p. 36-40 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Sclerostin-erbB-3 interactions: Modulation of erbB-3 activity by sclerostin

Craig, T. A. & Kumar, R., Nov 12 2010, In : Biochemical and Biophysical Research Communications. 402, 2, p. 421-424 4 p.

Research output: Contribution to journalArticle

8 Scopus citations
2009

Increased expression of secreted frizzled-related protein 4 in polycystic kidneys

Romaker, D., Puetz, M., Teschner, S., Donauer, J., Geyer, M., Gerke, P., Rumberger, B., Dworniczak, B., Pennekamp, P., Buchholz, B., Neumann, H. P. H., Kumar, R., Gloy, J., Eckardt, K. U. & Walz, G., Jan 1 2009, In : Journal of the American Society of Nephrology. 20, 1, p. 48-56 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Mechanisms of renal phosphate loss in liver resection-associated hypophosphatemia

Nafidi, O., Lapointe, R. W., Lepage, R., Kumar, R. & D'Amour, P., May 1 2009, In : Annals of surgery. 249, 5, p. 824-827 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Production and characterization of monoclonal antibodies to human sclerostin

Craig, T. A., Sommer, S. L., Beito, T. G. & Kumar, R., Oct 1 2009, In : Hybridoma. 28, 5, p. 377-381 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Quantification of urinary albumin by using protein cleavage and LC-MS/MS

Seegmiller, J. C., Barnidge, D. R., Burns, B. E., Larson, T. S., Lieske, J. C. & Kumar, R., Jun 1 2009, In : Clinical chemistry. 55, 6, p. 1100-1107 8 p.

Research output: Contribution to journalArticle

49 Scopus citations