Rajiv Kumar, M.B., B.S., M.A.C.P.

  • 14058 Citations
  • 61 Scopus h-Index
1975 …2019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1976 2019

2019

Lung tumor cells inhibit bone mineralization and osteoblast activity

Berent, T. E., Dorschner, J. M., Craig, T. A., Drake, M. M., Westendorf, J. J. & Kumar, R., Jan 1 2019, (Accepted/In press) In : Biochemical and Biophysical Research Communications.

Research output: Contribution to journalArticle

Physiologic Calcification
Osteoblasts
Conditioned Culture Medium
Tumors
Bone
2018
3 Citations (Scopus)

1α,25-dihydroxyvitamin D3 mitigates cancer cell mediated mitochondrial dysfunction in human skeletal muscle cells

Ryan, Z. C., Craig, T. A., Wang, X., Delmotte, P., Salisbury, J. L., Lanza, I. R., Sieck, G. C. & Kumar, R., Feb 5 2018, In : Biochemical and Biophysical Research Communications. 496, 2, p. 746-752 7 p.

Research output: Contribution to journalArticle

Calcitriol
Skeletal Myoblasts
Oxygen Consumption
Muscle Cells
Muscle
2 Citations (Scopus)

Comparison of the effect of daily versus bolus dose maternal vitamin D3 supplementation on the 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 ratio

Ketha, H., Thacher, T. D., Oberhelman, S. S., Fischer, P. R., Singh, R. J. & Kumar, R., May 1 2018, In : Bone. 110, p. 321-325 5 p.

Research output: Contribution to journalArticle

24,25-Dihydroxyvitamin D 3
Calcifediol
Cholecalciferol
Vitamin D
Mothers
2017
1 Citation (Scopus)

Hydrogen-Deuterium Exchange Mass Spectrometry Reveals Calcium Binding Properties and Allosteric Regulation of Downstream Regulatory Element Antagonist Modulator (DREAM)

Zhang, J., Li, J., Craig, T. A., Kumar, R. & Gross, M. L., Jul 18 2017, In : Biochemistry. 56, 28, p. 3523-3530 8 p.

Research output: Contribution to journalArticle

Kv Channel-Interacting Proteins
Allosteric Regulation
Deuterium
EF Hand Motifs
Mass spectrometry
5 Citations (Scopus)
Hyperparathyroidism
Chronic Renal Insufficiency
Vitamin D
Chronic Kidney Failure
Chronic Kidney Disease-Mineral and Bone Disorder

Vitamin D and the Kidney

Tebben, P. & Kumar, R., Dec 18 2017, Biochemistry, Physiology and Diagnostics. Elsevier Inc., Vol. 1. p. 437-459 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

vitamin D
Vitamin D
nephrons
kidneys
calbindin
2016
39 Citations (Scopus)

1α,25-dihydroxyvitamin D3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells

Ryan, Z. C., Craig, T. A., Folmes, C., Wang, X., Lanza, I. R., Schaible, N. S., Salisbury, J. L., Nair, K. S., Terzic, A., Sieck, G. C. & Kumar, R., Jan 15 2016, In : Journal of Biological Chemistry. 291, 3, p. 1514-1528 15 p., 15.

Research output: Contribution to journalArticle

Calcitriol
Oxygen Consumption
Muscle Cells
Muscle
Skeletal Muscle
4 Citations (Scopus)

Abnormalities in biomarkers of mineral and bone metabolism in kidney donors

Kasiske, B. L., Kumar, R., Kimmel, P. L., Pesavento, T. E., Kalil, R. S., Kraus, E. S., Rabb, H., Posselt, A. M., Anderson-Haag, T. L., Steffes, M. W., Israni, A. K., Snyder, J. J., Singh, R. J. & Weir, M. R., Mar 9 2016, (Accepted/In press) In : Kidney International.

Research output: Contribution to journalArticle

Minerals
Biomarkers
Tissue Donors
Kidney
Bone and Bones
16 Citations (Scopus)

Calciphylaxis: A Disease of Pannicular Thrombosis

el-Azhary, R. A., Patzelt, M. T., McBane, R. D., Weaver, A. L., Albright, R. C., Bridges, A. D., Claus, P. L., Davis, M. D. P., Dillon, J. J., El-Zoghby, Z. M., Hickson, L., Kumar, R., McCarthy-Fruin, K. A. M., McEvoy, M. T., Pittelkow, M. R., Wetter, D. A., Williams, A. W. & McCarthy, J. T., Oct 1 2016, In : Mayo Clinic Proceedings. 91, 10, p. 1395-1402 8 p.

Research output: Contribution to journalArticle

Calciphylaxis
Thrombosis
Thrombophilia
Survival
Warfarin
17 Citations (Scopus)

Clinical and biochemical phenotypes of adults with monoallelic and biallelic CYP24A1 mutations: evidence of gene dose effect

O’Keeffe, D. T., Tebben, P., Kumar, R., Singh, R. J., Wu, Y. & Wermers, R. A., Apr 29 2016, (Accepted/In press) In : Osteoporosis International. p. 1-5 5 p.

Research output: Contribution to journalArticle

Phenotype
Mutation
Genes
Nephrolithiasis
Hypercalcemia
27 Citations (Scopus)

LC-MS/MS for identifying patients with CYP24A1 mutations

Ketha, H., Kumar, R. & Singh, R. J., Jan 1 2016, In : Clinical Chemistry. 62, 1, p. 236-242 7 p.

Research output: Contribution to journalArticle

Mutation
Hypercalcemia
Genetic Testing
Testing
Dihydroxycholecalciferols
33 Citations (Scopus)

Survival, Risk Factors, and Effect of Treatment in 101 Patients With Calciphylaxis

McCarthy, J. T., el-Azhary, R. A., Patzelt, M. T., Weaver, A. L., Albright, R. C., Bridges, A. D., Claus, P. L., Davis, M. D. P., Dillon, J. J., El-Zoghby, Z. M., Hickson, L., Kumar, R., McBane, R. D., McCarthy-Fruin, K. A. M., McEvoy, M. T., Pittelkow, M. R., Wetter, D. A. & Williams, A. W., Oct 1 2016, In : Mayo Clinic Proceedings. 91, 10, p. 1384-1394 11 p.

Research output: Contribution to journalArticle

Calciphylaxis
Chronic Renal Insufficiency
Survival
Parathyroidectomy
Hyperparathyroidism
43 Citations (Scopus)

Vitamin D-mediated hypercalcemia: Mechanisms, diagnosis, and treatment

Tebben, P., Singh, R. J. & Kumar, R., 2016, In : Endocrine Reviews. 37, 5, p. 521-547 27 p.

Research output: Contribution to journalReview article

Hypercalcemia
Vitamin D
Hypercalciuria
Calcitriol Receptors
Mixed Function Oxygenases
2015
7 Citations (Scopus)
Metabolites
Parathyroid Hormone
Vitamin D
Bone
Calcium
15 Citations (Scopus)

Altered calcium and Vitamin D homeostasis in first-time calcium kidney stone-formers

Ketha, H., Singh, R. J., Grebe, S. K., Bergstralh, E. J., Rule, A. D., Lieske, J. C. & Kumar, R., Sep 2 2015, In : PLoS One. 10, 9, e0137350.

Research output: Contribution to journalArticle

renal calculi
Kidney Calculi
vitamin D
fibroblast growth factors
Vitamin D
52 Citations (Scopus)

A prospective controlled study of living kidney donors: Three-year follow-up

Kasiske, B. L., Anderson-Haag, T., Israni, A. K., Kalil, R. S., Kimmel, P. L., Kraus, E. S., Kumar, R., Posselt, A. A., Pesavento, T. E., Rabb, H., Steffes, M. W., Snyder, J. J. & Weir, M. R., Jul 1 2015, In : American Journal of Kidney Diseases. 66, 1, p. 114-124 11 p.

Research output: Contribution to journalArticle

Living Donors
Tissue Donors
Prospective Studies
Kidney
Blood Pressure
19 Citations (Scopus)

Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3

Ryan, Z. C., Craig, T. A., Filoteo, A. G., Westendorf, J. J., Cartwright, E. J., Neyses, L., Strehler, E. E. & Kumar, R., Nov 6 2015, In : Biochemical and Biophysical Research Communications. 467, 1, p. 152-156 5 p.

Research output: Contribution to journalArticle

Calcitriol
Cell membranes
Bone Density
Minerals
Protein Isoforms
2 Citations (Scopus)

Follicular lymphoma presenting with hypercalcaemia: An unusual mechanism of hypercalcaemia

Martens, P., Addissie, B. & Kumar, R., Jun 1 2015, In : Acta Clinica Belgica: International Journal of Clinical and Laboratory Medicine. 70, 3, p. 200-203 4 p.

Research output: Contribution to journalArticle

Follicular Lymphoma
Hypercalcemia
Lymphoma
Neoplasms
Cytokines
1 Citation (Scopus)
Parathyroid Hormone
Chronic Kidney Failure
Clinical Trials
Serum
Secondary Hyperparathyroidism
2014
57 Citations (Scopus)

A lifetime of hypercalcemia and hypercalciuria, finally explained

Jacobs, T. P., Kaufman, M., Jones, G., Kumar, R., Schlingmann, K. P., Shapses, S. & Bilezikian, J. P., 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 3, p. 708-712 5 p.

Research output: Contribution to journalArticle

Hypercalciuria
Hypercalcemia
Ketoconazole
Nephrolithiasis
Prednisone
9 Citations (Scopus)

Detection of 1α,25-dihydroxyvitamin D-regulated miRNAs in zebrafish by whole transcriptome sequencing

Craig, T. A., Zhang, Y., Magis, A. T., Funk, C. C., Price, N. D., Ekker, S. C. & Kumar, R., Jun 1 2014, In : Zebrafish. 11, 3, p. 207-218 12 p.

Research output: Contribution to journalArticle

Zebrafish
MicroRNAs
transcriptomics
Danio rerio
microRNA
3 Citations (Scopus)

Enhanced prostacyclin formation and Wnt signaling in sclerostin deficient osteocytes and bone

Ryan, Z. C., Craig, T. A., Salisbury, J. L., Carpio, L. R., McGee-Lawrence, M., Westendorf, J. J. & Kumar, R., May 23 2014, In : Biochemical and Biophysical Research Communications. 448, 1, p. 83-88 6 p.

Research output: Contribution to journalArticle

Osteocytes
Epoprostenol
Bone
Bone and Bones
Osteoblasts
19 Citations (Scopus)

Gastric bypass surgery and measured and estimated GFR in women

Lieske, J. C., Collazo-Clavell, M. L., Sarr, M. G., Rule, A. D., Bergstralh, E. J. & Kumar, R., Oct 1 2014, In : American Journal of Kidney Diseases. 64, 4, p. 663-665 3 p.

Research output: Contribution to journalArticle

Bariatric Surgery
Gastric Bypass
Postoperative Care
Glomerular Filtration Rate
Body Mass Index
9 Citations (Scopus)
Calcium
Kidney
Bone and Bones
Parathyroid Hormone
Renal Elimination
12 Citations (Scopus)

The role of Iex-1 in the pathogenesis of venous neointimal hyperplasia associated with hemodialysis arteriovenous fistula

Brahmbhatt, A., NievesTorres, E., Yang, B., Edwards, W. D., Chaudhury, P. R., Lee, M. K., Kong, H., Mukhopadhyay, D., Kumar, R. & Misra, S., Jul 18 2014, In : PLoS One. 9, 7, e102542.

Research output: Contribution to journalArticle

hemodialysis
fistula
Arteriovenous Fistula
hyperplasia
Vascular Endothelial Growth Factor A
23 Citations (Scopus)

Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF-kB pathways and their target, IEX-1

De Laval, B., Pawlikowska, P., Barbieri, D., Besnard-Guerin, C., Cico, A., Kumar, R., Gaudry, M., Baud, V. & Porteu, F., Jan 23 2014, In : Blood. 123, 4, p. 509-519 11 p.

Research output: Contribution to journalArticle

DNA End-Joining Repair
Thrombopoietin
NF-kappa B
Hematopoietic Stem Cells
Stem cells
2013
12 Citations (Scopus)

Characterization of the effect of chronic administration of a calcium-sensing receptor antagonist, ronacaleret, on renal calcium excretion and serum calcium in postmenopausal women

Caltabiano, S., Dollery, C. T., Hossain, M., Kurtinecz, M. T., Desjardins, J. P., Favus, M. J., Kumar, R. & Fitzpatrick, L. A., Sep 2013, In : Bone. 56, 1, p. 154-162 9 p.

Research output: Contribution to journalArticle

Calcium-Sensing Receptors
Calcium
Parathyroid Hormone
Serum
Anabolic Agents
1 Citation (Scopus)

Clinical Disturbances of Phosphate Homeostasis

Berndt, T. J. & Kumar, R., 2013, Seldin and Geibisch's The Kidney. Elsevier Inc., Vol. 2. p. 2369-2391 23 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Homeostasis
Phosphates

Corrigendum to "Histone deacetylase 3 is required for maintenance of bone mass during aging" [Bone 52 (2013) 296-307]

McGee-Lawrence, M. E., Bradley, E., Dudakovic, A., Carlson, S. W., Ryan, Z. C., Kumar, R., Dadsetan, M., Yaszemski, M. J., Chen, Q., An, K. N. & Westendorf, J. J., Mar 2013, In : Bone. 53, 1, p. 320 1 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

H/D exchange centroid monitoring is insufficient to show differences in the behavior of protein states

Zhang, J., Ramachandran, P., Kumar, R. & Gross, M. L., Mar 2013, In : Journal of the American Society for Mass Spectrometry. 24, 3, p. 450-453 4 p.

Research output: Contribution to journalArticle

Deuterium
Monitoring
Hydrogen
Proteins
Oligomerization
43 Citations (Scopus)

Histone deacetylase 3 is required for maintenance of bone mass during aging

McGee-Lawrence, M. E., Bradley, E., Dudakovic, A., Carlson, S. W., Ryan, Z. C., Kumar, R., Dadsetan, M., Yaszemski, M. J., Chen, Q., An, K. N. & Westendorf, J. J., Jan 2013, In : Bone. 52, 1, p. 296-307 12 p.

Research output: Contribution to journalArticle

Maintenance
Bone and Bones
Osteoblasts
Osteocytes
histone deacetylase 3
26 Citations (Scopus)

Oral paricalcitol reduces the prevalence of posttransplant hyperparathyroidism: Results of an open label randomized trial

Amer, H., Griffin, M. D., Stegall, M. D., Cosio, F. G., Park, W. D., Kremers, W. K., Heilman, R. L., Mazur, M. J., Hamawi, K., Larson, T. S. & Kumar, R., Jun 2013, In : American Journal of Transplantation. 13, 6, p. 1576-1585 10 p.

Research output: Contribution to journalArticle

Hyperparathyroidism
Kidney
Hypercalcemia
Allografts
Calcium
1 Citation (Scopus)

Osteocalcin and the regulation of glucose metabolism

Vella, A. & Kumar, R., Mar 2013, In : Clinical Reviews in Bone and Mineral Metabolism. 11, 1, p. 11-16 6 p.

Research output: Contribution to journalArticle

Osteocalcin
Glucose
Insulin
Adipokines
Vitamin K

Phosphatonins

Tebben, P., Berndt, T. J. & Kumar, R., Jun 2013, Osteoporosis: Fourth Edition. Elsevier Inc., p. 373-390 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Homeostasis
Phosphates
Phosphorus
Extracellular Matrix
Familial Hypophosphatemia
66 Citations (Scopus)

Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium

Ryan, Z. C., Ketha, H., McNulty, M. S., McGee-Lawrence, M., Craig, T. A., Grande, J. P., Westendorf, J. J., Singh, R. J. & Kumar, R., Apr 9 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 15, p. 6199-6204 6 p.

Research output: Contribution to journalArticle

Knockout Mice
Vitamin D
Calcium
Serum
Galactosidases
28 Citations (Scopus)

Sclerostin deficient mice rapidly heal bone defects by activating β-catenin and increasing intramembranous ossification

McGee-Lawrence, M. E., Ryan, Z. C., Carpio, L. R., Kakar, S., Westendorf, J. J. & Kumar, R., Nov 29 2013, In : Biochemical and Biophysical Research Communications. 441, 4, p. 886-890 5 p.

Research output: Contribution to journalArticle

Catenins
Osteogenesis
Bone
Bone and Bones
Defects
6 Citations (Scopus)
Antibodies
Serum
Asthma
25-hydroxyvitamin D
Least-Squares Analysis
5 Citations (Scopus)

The Hormonal Regulation of Calcium Metabolism

Tebben, P. & Kumar, R., 2013, Seldin and Geibisch's The Kidney. Elsevier Inc., Vol. 2. p. 2249-2272 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Calcium
10 Citations (Scopus)
Kv Channel-Interacting Proteins
Hexokinase
Apoptosis
Mitochondria
Neuroblastoma
2012
7 Citations (Scopus)

Expression of sclerostin in the developing zebrafish (Danio rerio) brain and skeleton

McNulty, M. S., Bedell, V. M., Greenwood, T. M., Craig, T. A., Ekker, S. C. & Kumar, R., Aug 2012, In : Gene Expression Patterns. 12, 7-8, p. 228-235 8 p.

Research output: Contribution to journalArticle

Zebrafish
Fertilization
Skeleton
Brain
Cartilage
2 Citations (Scopus)

Hydrogen/deuterium exchange reflects binding of human centrin 2 to Ca 2+ and Xeroderma pigmentosum Group C peptide: An example of EX1 kinetics

Sperry, J. B., Ryan, Z. C., Kumar, R. & Gross, M. L., Dec 15 2012, In : International Journal of Mass Spectrometry. 330-332, p. 302-309 8 p.

Research output: Contribution to journalArticle

C-Peptide
Deuterium
Calmodulin
Peptides
peptides
89 Citations (Scopus)
Hypercalciuria
Ketoconazole
Calcitriol
Hypercalcemia
Genes
12 Citations (Scopus)

The potassium channel interacting protein 3 (DREAM/KChIP3) heterodimerizes with and regulates calmodulin function.

Ramachandran, P. L., Craig, T. A., Atanasova, E. A., Cui, G., Owen, B. A., Bergen, H. R. B. III., Mer, G. & Kumar, R., Nov 16 2012, In : The Journal of biological chemistry. 287, 47, p. 39439-39448 10 p.

Research output: Contribution to journalArticle

Kv Channel-Interacting Proteins
Calmodulin
Calcineurin
EF Hand Motifs
Proteins
27 Citations (Scopus)

The sclerostin-bone protein interactome

Devarajan-Ketha, H., Craig, T. A., Madden, B. J., Bergen, H. R. B. III. & Kumar, R., Jan 13 2012, In : Biochemical and Biophysical Research Communications. 417, 2, p. 830-835 6 p.

Research output: Contribution to journalArticle

Bone
Maltose-Binding Proteins
Bone and Bones
Amylose
Proteins
29 Citations (Scopus)

Vitamin D and the kidney

Kumar, R., Tebben, P. & Thompson, J. R., Jul 1 2012, In : Archives of Biochemistry and Biophysics. 523, 1, p. 77-86 10 p.

Research output: Contribution to journalArticle

Vitamin D
Phosphorus
Mixed Function Oxygenases
Parathyroid Hormone
Kidney
24 Citations (Scopus)

Whole transcriptome RNA sequencing detects multiple 1α 25- dihydroxyvitamin D3-sensitive metabolic pathways in developing zebrafish

Craig, T. A., Zhang, Y., McNulty, M. S., Middha, S., Ketha, H., Singh, R. J., Magis, A. T., Funk, C., Price, N. D., Ekker, S. C. & Kumar, R., Sep 2012, In : Molecular Endocrinology. 26, 9, p. 1630-1642 13 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Calcitriol
Zebrafish
Metabolic Networks and Pathways
Transcriptome
2011
11 Citations (Scopus)

Carbohydrate metabolism and the skeleton: Picking a bone with the β-cell

Kumar, R. & Vella, A., May 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 5, p. 1269-1271 3 p.

Research output: Contribution to journalArticle

Osteocalcin
Carbohydrate Metabolism
Skeleton
Bone
Bone and Bones
47 Citations (Scopus)

Determination of serum and plasma sclerostin concentrations by enzyme-linked immunoassays

McNulty, M., Singh, R. J., Li, X., Bergstralh, E. J. & Kumar, R., Jul 1 2011, In : Journal of Clinical Endocrinology and Metabolism. 96, 7

Research output: Contribution to journalArticle

Immunoenzyme Techniques
Assays
Plasmas
Enzymes
Serum

Fat malabsorption and increased intestinal oxalate absorption are common after roux-en-y gastric bypass surgery

Kumar, R., Lieske, J. C., Collazo-Clavell, M. L., Sarr, M. G., Olson, E. R., Vrtiska, T. J., Bergstralh, E. J. & Li, X., Aug 2011, In : Journal of Urology. 186, 2, p. 577 1 p.

Research output: Contribution to journalArticle

Gastric Bypass
Oxalates
Intestinal Absorption
Fats
95 Citations (Scopus)

Fat malabsorption and increased intestinal oxalate absorption are common after roux-en-Y gastric bypass surgery

Kumar, R., Lieske, J. C., Collazo-Clavell, M. L., Sarr, M. G., Olson, E. R., Vrtiska, T. J., Bergstralh, E. J. & Li, X., May 2011, In : Surgery. 149, 5, p. 654-661 8 p.

Research output: Contribution to journalArticle

Gastric Bypass
Oxalates
Intestinal Absorption
Fats
Calcium Oxalate