• 30294 Citations
  • 94 Scopus h-Index
19962020
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Research Output 1996 2019

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Article
2019

Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma

Sahin, I., Kawano, Y., Sklavenitis-Pistofidis, R., Moschetta, M., Mishima, Y., Manier, S., Sacco, A., Carrasco, R., Fonseca, R., Roccaro, A. M., Witzig, T. E. & Ghobrial, I. M., Apr 9 2019, In : Blood Advances. 3, 7, p. 995-1002 8 p.

Research output: Contribution to journalArticle

Open Access
Cytokinesis
Multiple Myeloma
Growth
Neoplasms
Protein-Serine-Threonine Kinases
1 Citation (Scopus)

Incidence of skeletal-related events among multiple myeloma patients in the United States at oncology clinics: Observations from real-world data

Kim, C., Bhatta, S., Cyprien, L., Fonseca, R. & Hernandez, R. K., Feb 1 2019, In : Journal of Bone Oncology. 14, 100215.

Research output: Contribution to journalArticle

Multiple Myeloma
Incidence
History
Proteasome Inhibitors
Electronic Health Records
2018
5 Citations (Scopus)

Evaluation of Revised International Staging System (R-ISS) for transplant-eligible multiple myeloma patients

González-Calle, V., Slack, A., Keane, N., Luft, S., Pearce, K. E., Ketterling, R. P., Jain, T., Chirackal, S., Reeder, C., Mikhael, J. R., Noel, P., Mayo, A., Adams, R. H., Ahmann, G., Braggio, E. D., Stewart, A. K., Bergsagel, P. L., van Wier, S. A. & Fonseca, R., Apr 6 2018, (Accepted/In press) In : Annals of Hematology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Transplants
Survival
Chromosome Aberrations
Stem Cells
3 Citations (Scopus)
Stem Cell Transplantation
Multiple Myeloma
Meta-Analysis
Transplantation
Drug Therapy
3 Citations (Scopus)

Phase 1/2 trial of ixazomib, cyclophosphamide and dexamethasone in patients with previously untreated symptomatic multiple myeloma

Kumar, S. K., Buadi, F. K., LaPlant, B., Halvorson, A., Leung, N., Kapoor, P., Dingli, D. M., Gertz, M., Go, R. S., Bergsagel, P. L., Lin, Y., Dispenzieri, A., Hwa, Y. L., Fonder, A., Hobbs, M., Fonseca, R., Hayman, S. R., Stewart, A. K., Lust, J. A., Mikhael, J. R. & 5 others, Gonsalves, W., Reeder, C., Skacel, T., Rajkumar, S. V. & Lacy, M., Aug 1 2018, In : Blood Cancer Journal. 8, 8, 70.

Research output: Contribution to journalArticle

Multiple Myeloma
Cyclophosphamide
Dexamethasone
Maximum Tolerated Dose
Proteasome Inhibitors
6 Citations (Scopus)

Pomalidomide-dexamethasone in refractory multiple myeloma: Long-term follow-up of a multi-cohort phase II clinical trial

Ailawadhi, S., Mikhael, J. R., Laplant, B. R., Laumann, K. M., Kumar, S. K., Roy, V., Dingli, D. M., Bergsagel, P. L., Buadi, F. K., Rajkumar, S. V., Fonseca, R., Gertz, M., Kapoor, P., Sher, T., Hayman, S. R., Stewart, A. K., Dispenzieri, A., Kyle, R. A., Gonsalves, W., Reeder, C. B. & 8 others, Lin, Y., Go, R. S., Leung, N., Kourelis, T., Lust, J. A., Russell, S. J., Chanan Khan, A. A. & Lacy, M., Mar 1 2018, In : Leukemia. 32, 3, p. 719-728 10 p.

Research output: Contribution to journalArticle

Phase II Clinical Trials
Multiple Myeloma
Dexamethasone
Appointments and Schedules
Therapeutics
33 Citations (Scopus)

Selective inhibition of nuclear export with oral selinexor for treatment of relapsed or refractory multiple myeloma

Vogl, D. T., Dingli, D. M., Cornell, R. F., Huff, C. A., Jagannath, S., Bhutani, D., Zonder, J., Baz, R., Nooka, A., Richter, J., Cole, C., Vij, R., Jakubowiak, A., Abonour, R., Schiller, G., Parker, T. L., Costa, L. J., Kaminetzky, D., Hoffman, J. E., Yee, A. J. & 12 others, Chari, A., Siegel, D., Fonseca, R., Van Wier, S., Ahmann, G., Lopez, I., Kauffman, M., Shacham, S., Saint-Martin, J. R., Picklesimer, C. D., Choe-Juliak, C. & Stewart, A. K., Jan 1 2018, In : Journal of Clinical Oncology. 36, 9, p. 859-866 8 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Multiple Myeloma
Rubiaceae
Therapeutics
Dexamethasone
1 Citation (Scopus)

The Importance of Economic Trade-offs in Cancer Drug Pricing

Fonseca, R., Peneva, D., Clancy, Z., Abouzaid, S. & Jena, A. B., Jan 1 2018, (Accepted/In press) In : Mayo Clinic Proceedings.

Research output: Contribution to journalArticle

Economics
Costs and Cost Analysis
Pharmaceutical Preparations
Neoplasms

Treatment With Bortezomib-based Therapy, Followed by Autologous Stem Cell Transplantation, Improves Outcomes in Light Chain Amyloidosis: A Retrospective Study

Jain, T., Kosiorek, H. E., Kung, S. T., Shah, V. S., Dueck, A., Gonzalez-Calle, V., Luft, S., Reeder, C. B., Adams, R., Noel, P., Larsen, J. T., Mikhael, J. R., Bergsagel, P. L., Stewart, A. K. & Fonseca, R., Jan 1 2018, (Accepted/In press) In : Clinical Lymphoma, Myeloma and Leukemia.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Amyloidosis
Retrospective Studies
Light
Therapeutics
11 Citations (Scopus)

Utilization of hematopoietic stem cell transplantation for the treatment of multiple myeloma: a Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus statement

Gonsalves, W., Buadi, F. K., Ailawadhi, S., Bergsagel, P. L., Chanan Khan, A. A., Dingli, D. M., Dispenzieri, A., Fonseca, R., Hayman, S. R., Kapoor, P., Kourelis, T., Lacy, M., Larsen, J. T., Muchtar, E., Reeder, C. B., Sher, T., Stewart, A. K., Warsame, R., Go, R. S., Kyle, R. A. & 14 others, Leung, N., Lin, Y., Lust, J. A., Russell, S. J., Zeldenrust, S. R., Fonder, A. L., Hwa, Y. L., Hobbs, M. A., Mayo, A. A., Hogan, W., Rajkumar, S. V., Kumar, S. K., Gertz, M. & Roy, V., Jul 9 2018, (Accepted/In press) In : Bone Marrow Transplantation. p. 1-15 15 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Multiple Myeloma
Stem Cells
Transplants
Therapeutics
2017
4 Citations (Scopus)

A phase 2 study of lenalidomide, rituximab, cyclophosphamide, and dexamethasone (LR-CD) for untreated low-grade non-Hodgkin lymphoma requiring therapy

Rosenthal, A., Dueck, A., Ansell, S. M., Gano, K., Conley, C., Nowakowski, G. S., Camoriano, J. K., Leis, J. F., Mikhael, J. R., Stewart, A. K., Inwards, D., Dingli, D. M., Kumar, S. K., Noel, P., Gertz, M., Porrata, L., Russell, S. J., Colgan, J., Fonseca, R., Habermann, T. M. & 6 others, Kapoor, P., Buadi, F., Leung, N., Tiedemann, R., Witzig, T. E. & Reeder, C., May 1 2017, In : American Journal of Hematology. 92, 5, p. 467-472 6 p.

Research output: Contribution to journalArticle

Non-Hodgkin's Lymphoma
Cyclophosphamide
Dexamethasone
Lymphoma
B-Cell Lymphoma
42 Citations (Scopus)

Diagnosis and management of Waldenström macroglobulinemia: Mayo Stratification of Macroglobulinemia and Risk-Adapted Therapy (mSMART) guidelines 2016

Kapoor, P., Ansell, S. M., Fonseca, R., Chanan Khan, A. A., Kyle, R. A., Kumar, S. K., Mikhael, J. R., Witzig, T. E., Mauermann, M. M., Dispenzieri, A., Ailawadhi, S., Stewart, A. K., Lacy, M., Thompson, C. A., Buadi, F. K., Dingli, D. M., Morice, W. G., Go, R. S., Jevremovic, D., Sher, T. & 27 others, King, R. L., Braggio, E. D., Novak, A. J., Roy, V., Ketterling, R. P., Greipp, P. T., Grogan, M., Micallef, I., Bergsagel, P. L., Colgan, J. P., Leung, N., Gonsalves, W., Lin, Y., Inwards, D. J., Hayman, S. R., Nowakowski, G. S., Johnston, P. B., Russell, S. J., Markovic, S. N., Zeldenrust, S. R., Hwa, Y. L., Lust, J. A., Porrata, L. F., Habermann, T. M., Rajkumar, S. V., Gertz, M. & Reeder, C. B., Sep 1 2017, In : JAMA oncology. 3, 9, p. 1257-1265 9 p.

Research output: Contribution to journalArticle

Waldenstrom Macroglobulinemia
Guidelines
Stem Cell Transplantation
Therapeutics
Clinical Trials
8 Citations (Scopus)

Hereditary lysozyme amyloidosis variant p.Leu102Ser associates with unique phenotype

Nasr, S. H., Dasari, S., Mills, J. R., Theis, J. D., Zimmermann, M. T., Fonseca, R., Vrana, J. A., Lester, S. J., McLaughlin, B. M., Gillespie, R., Highsmith, W. E. J., Lee, J. J., Dispenzieri, A. & Kurtin, P. J., Feb 1 2017, In : Journal of the American Society of Nephrology. 28, 2, p. 431-438 8 p.

Research output: Contribution to journalArticle

Familial Amyloidosis
Muramidase
Phenotype
Kidney
Amyloid Plaques
5 Citations (Scopus)

Multiple myeloma cells' capacity to decompose H2O2 determines lenalidomide sensitivity

Sebastian, S., Zhu, Y. X., Braggio, E. D., Shi, C. X., Panchabhai, S. C., Van Wier, S. A., Ahmann, G. J., Chesi, M., Bergsagel, P. L., Stewart, A. K. & Fonseca, R., Feb 23 2017, In : Blood. 129, 8, p. 991-1007 17 p.

Research output: Contribution to journalArticle

Thioredoxin-Disulfide Reductase
Multiple Myeloma
Cytotoxicity
Thioredoxins
Cells
22 Citations (Scopus)

Pomalidomide, bortezomib, and dexamethasone for patients with relapsed lenalidomide-refractory multiple myeloma

Paludo, J., Mikhael, J. R., Laplant, B. R., Halvorson, A. E., Kumar, S. K., Gertz, M., Hayman, S. R., Buadi, F. K., Dispenzieri, A., Lust, J. A., Kapoor, P., Leung, N., Russell, S. J., Dingli, D. M., Go, R. S., Lin, Y., Gonsalves, W., Fonseca, R., Bergsagel, P. L., Roy, V. & 8 others, Sher, T., Chanan Khan, A. A., Ailawadhi, S., Stewart, A. K., Reeder, C. B., Richardson, P. G., Rajkumar, S. V. & Lacy, M., Sep 7 2017, In : Blood. 130, 10, p. 1198-1204 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Refractory materials
Dexamethasone
Toxicity
Physical vapor deposition
1 Citation (Scopus)

Precision Medicine in Myeloma: Challenges in Defining an Actionable Approach

González-Calle, V., Keane, N., Braggio, E. D. & Fonseca, R., 2017, (Accepted/In press) In : Clinical Lymphoma, Myeloma and Leukemia.

Research output: Contribution to journalArticle

Precision Medicine
Multiple Myeloma
Patient Rights
Pharmaceutical Preparations
Biomarkers

Prevalence of BCL-2/J(H) Translocation in Healthy African Americans

Colon-Otero, G., Van Wier, S. A., Ahmann, G. J., Braggio, E. D., Albertie, M. L., Weis, J. A., Ailawadhi, S., Cerhan, J. R., Vishnu, P., Jorgensen, M. S., Foran, J. M., Thomas, C. S. & Fonseca, R., Jan 1 2017, In : Annals of Hematology. 96, 1, p. 51-55 5 p.

Research output: Contribution to journalArticle

African Americans
Follicular Lymphoma
Lymphocytes
Polymerase Chain Reaction
DNA
2 Citations (Scopus)

Prognostic Validation of SKY92 and Its Combination With ISS in an Independent Cohort of Patients With Multiple Myeloma

van Beers, E. H., van Vliet, M. H., Kuiper, R., de Best, L., Anderson, K. C., Chari, A., Jagannath, S., Jakubowiak, A., Kumar, S. K., Levy, J. B., Auclair, D., Lonial, S., Reece, D., Richardson, P., Siegel, D. S., Stewart, A. K., Trudel, S., Vij, R., Zimmerman, T. M. & Fonseca, R., 2017, (Accepted/In press) In : Clinical Lymphoma, Myeloma and Leukemia.

Research output: Contribution to journalArticle

Multiple Myeloma
Centrosome
Testicular Neoplasms
Gene Expression
Antigens

Retos y avances hacia la medicina de precisión en el mieloma múltiple

Translated title of the contribution: Towards precision medicine in myeloma: New evidence and challengesGonzález-Calle, V. & Fonseca, R., Jun 1 2017, In : Medicina (Argentina). 77, 3, p. 222-226 5 p.

Research output: Contribution to journalArticle

Precision Medicine
Multiple Myeloma
Biomarkers
Quality of Life
Clinical Trials
71 Citations (Scopus)

Trends in overall survival and costs of multiple myeloma, 2000–2014

Fonseca, R., Abouzaid, S., Bonafede, M., Cai, Q., Parikh, K., Cosler, L. & Richardson, P., Jan 20 2017, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Multiple Myeloma
Costs and Cost Analysis
Survival
United States Social Security Administration
Drug Costs
2016

Bone disease in Myeloma: The claws of CRAB

Fonseca, R. & Jain, T., Mar 15 2016, In : Clinical Cancer Research. 22, 6, p. 1301-1303 3 p.

Research output: Contribution to journalArticle

Hoof and Claw
Bone Diseases
Diphosphonates
Biomarkers
Bone and Bones
35 Citations (Scopus)

Carfilzomib and the cardiorenal system in myeloma: An endothelial effect?

Rosenthal, A., Luthi, J., Belohlavek, M., Kortüm, K. M., Mookadam, F., Mayo, A., Fonseca, R., Bergsagel, P. L., Reeder, C. B., Mikhael, J. R. & Stewart, A. K., 2016, In : Blood Cancer Journal. 6, 1, e384.

Research output: Contribution to journalArticle

Creatinine
Clinical Trials
Blood Pressure
Therapeutics
Troponin
50 Citations (Scopus)

Carfilzomib significantly improves the progression-free survival of high-risk patients in multiple myeloma

Avet-Loiseau, H., Fonseca, R., Siegel, D., Dimopoulos, M. A., Špička, I., Masszi, T., Hájek, R., Rosiñol, L., Goranova-Marinova, V., Mihaylov, G., Maisnar, V., Mateos, M. V., Wang, M., Niesvizky, R., Oriol, A., Jakubowiak, A., Minarik, J., Palumbo, A., Bensinger, W., Kukreti, V. & 4 others, Ben-Yehuda, D., Stewart, A. K., Obreja, M. & Moreau, P., Sep 1 2016, In : Blood. 128, 9, p. 1174-1180 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Cytogenetics
Disease-Free Survival
Dexamethasone
carfilzomib
10 Citations (Scopus)

Clinical Implementation of Integrated Genomic Profiling in Patients with Advanced Cancers

Borad, M. J., Egan, J. B., Condjella, R. M., Liang, W. S., Fonseca, R., Ritacca, N. R., McCullough, A. E., Barrett, M., Hunt, K. S., Champion, M. D., Patel, M. D., Young, S. W., Silva, A. C., Ho, T. H., Halfdanarson, T. R., Mc Williams, R. R., Lazaridis, K. N., Ramanathan, R. K., Baker, A., Aldrich, J. & 17 others, Kurdoglu, A., Izatt, T., Christoforides, A., Cherni, I., Nasser, S., Reiman, R., Cuyugan, L., McDonald, J., Adkins, J., Mastrian, S. D., Valdez, R., Jaroszewski, D. E., Von Hoff, D. D., Craig, D. W., Stewart, A. K., Carpten, J. D. & Bryce, A. H., 2016, In : Scientific Reports. 6, 1, 25.

Research output: Contribution to journalArticle

Neoplasms
Therapeutics
DNA Fingerprinting
Patient Preference
Pharmaceutical Preparations

Comprehensive Genomic Analysis of Metastatic Mucinous Urethral Adenocarcinoma Guides Precision Oncology Treatment: Targetable EGFR Amplification Leading to Successful Treatment With Erlotinib

Bryce, A. H., Borad, M. J., Egan, J. B., Condjella, R. M., Liang, W. S., Fonseca, R., McCullough, A. E., Hunt, K. S., Ritacca, N. R., Barrett, M., Patel, M. D., Young, S. W., Silva, A. C., Ho, T. H., Halfdanarson, T. R., Stanton, M. L., Cheville, J., Swanson, S., Schneider, D. E., Mc Williams, R. R. & 16 others, Baker, A., Aldrich, J., Kurdoglu, A., Izatt, T., Christoforides, A., Cherni, I., Nasser, S., Reiman, R., Cuyugan, L., McDonald, J., Adkins, J., Mastrian, S. D., Von Hoff, D. D., Craig, D. W., Stewart, A. K. & Carpten, J. D., Nov 3 2016, (Accepted/In press) In : Clinical Genitourinary Cancer.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Erdheim Chester Disease treated successfully with cladribine

Azadeh, N., Tazelaar, H. D., Gotway, M., Mookadam, F. & Fonseca, R., 2016, In : Respiratory Medicine Case Reports. 18, p. 37-40 4 p.

Research output: Contribution to journalArticle

Erdheim-Chester Disease
Cladribine
Mutation
Monocytes
Proto-Oncogene Proteins B-raf
15 Citations (Scopus)

Genomic characterization of high-count MBL cases indicates that early detection of driver mutations and subclonal expansion are predictors of adverse clinical outcome

Barrio, S., Shanafelt, T. D., Ojha, J., Chaffee, K. G., Secreto, C., Kortüm, K. M., Pathangey, S., Van-Dyke, D. L., Slager, S. L., Fonseca, R., Kay, N. E. & Braggio, E. D., Jul 29 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Lymphocytosis
B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Mutation
Clonal Evolution
49 Citations (Scopus)

IAP antagonists induce anti-tumor immunity in multiple myeloma

Chesi, M., Mirza, N. N., Garbitt, V. M., Sharik, M. E., Dueck, A., Asmann, Y., Akhmetzyanova, I., Kosiorek, H. E., Calcinotto, A., Riggs, D. L., Keane, N., Ahmann, G. J., Morrison, K. M., Fonseca, R., Lacy, M., Dingli, D. M., Kumar, S. K., Ailawadhi, S., Dispenzieri, A., Buadi, F. & 7 others, Gertz, M., Reeder, C. B., Lin, Y., Chanan Khan, A. A., Stewart, A. K., Fooksman, D. & Bergsagel, P. L., Dec 1 2016, In : Nature Medicine. 22, 12, p. 1411-1420 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Tumors
Immunity
Apoptosis
Neoplasms
5 Citations (Scopus)

Outcome with lenalidomide plus dexamethasone followed by early autologous stem cell transplantation in patients with newly diagnosed multiple myeloma on the ECOG-ACRIN E4A03 randomized clinical trial: Long-term follow-up

Biran, N., Jacobus, S., Vesole, D. H., Callander, N. S., Fonseca, R., Williams, M. E., Abonour, R., Katz, M. S., Rajkumar, S. V., Greipp, P. R. & Siegel, D. S., Sep 2 2016, In : Blood Cancer Journal. 6, 9, e466.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Multiple Myeloma
Dexamethasone
Randomized Controlled Trials
Transplants
25 Citations (Scopus)

Panel sequencing for clinically oriented variant screening and copy number detection in 142 untreated multiple myeloma patients

Kortuem, K. M., Braggio, E. D., Bruins, L., Barrio, S., Shi, C. S., Zhu, Y. X., Tibes, R., Viswanatha, D., Votruba, P., Ahmann, G., Fonseca, R., Jedlowski, P., Schlam, I., Kumar, S. K., Bergsagel, P. L. & Stewart, A. K., 2016, In : Blood Cancer Journal. 6, 2, e397.

Research output: Contribution to journalArticle

Multiple Myeloma
Mutation
Genes
Costs and Cost Analysis
Pharmaceutical Preparations
13 Citations (Scopus)

PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation

Teoh, P. J., Bi, C., Sintosebastian, C., Tay, L. S., Fonseca, R. & Chng, W. J., 2016, In : Oncotarget. 7, 38, p. 61806-61819 14 p.

Research output: Contribution to journalArticle

Myeloma Proteins
Endoplasmic Reticulum Stress
Multiple Myeloma
Homeostasis
Protein Conformation
2 Citations (Scopus)
Multiple Myeloma
Dexamethasone
Therapeutics
lenalidomide
Bortezomib
2015
10 Citations (Scopus)

Carfilzomib: A cause of drug associated thrombotic microangiopathy

Qaqish, I., Schlam, I. M., Chakkera, H. M., Fonseca, R. & Adamski, J., Aug 24 2015, (Accepted/In press) In : Transfusion and Apheresis Science.

Research output: Contribution to journalArticle

Thrombotic Microangiopathies
Plasma Exchange
Multiple Myeloma
Pharmaceutical Preparations
Therapeutics
35 Citations (Scopus)

Deep sequencing identifies genetic heterogeneity and recurrent convergent evolution in chronic lymphocytic leukemia

Ojha, J., Ayres, J., Secreto, C., Tschumper, R., Rabe, K., Van Dyke, D., Slager, S. L., Shanafelt, T., Fonseca, R., Kay, N. E. & Braggio, E. D., Jan 15 2015, In : Blood. 125, 3, p. 492-498 7 p.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Genetic Heterogeneity
B-Cell Chronic Lymphocytic Leukemia
Genes
Microarrays
79 Citations (Scopus)

Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma

Mayo Phase Consortium, Jan 15 2015, In : Blood. 125, 3, p. 443-448 6 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinases
Multiple Myeloma
CDC2 Protein Kinase
Proteasome Inhibitors
Stabilization
3 Citations (Scopus)

Extramedullary Cardiac Multiple Myeloma-A Case Report and Contemporary Review of the Literature

Coakley, M., Yeneneh, B., Rosenthal, A., Fonseca, R. & Mookadam, F., Nov 29 2015, (Accepted/In press) In : Clinical Lymphoma, Myeloma and Leukemia.

Research output: Contribution to journalArticle

Multiple Myeloma
Plasmacytoma
Takotsubo Cardiomyopathy
Recurrence
Cardiac Tamponade
68 Citations (Scopus)

Genome-wide analysis uncovers novel recurrent alterations in primary central nervous system lymphomas

Braggio, E. D., Van Wier, S., Ojha, J., McPhail, E., Asmann, Y., Egan, J., Da Silva, J. A., Schiff, D., Lopes, M. B., Decker, P. A., Valdez, R., Tibes, R., Eckloff, B., Witzig, T. E., Stewart, A. K., Fonseca, R. & O'Neill, B. P., Sep 1 2015, In : Clinical Cancer Research. 21, 17, p. 3986-3994 9 p.

Research output: Contribution to journalArticle

Lymphoma
Central Nervous System
Genome
Lymphoma, Large B-Cell, Diffuse
Exome
29 Citations (Scopus)

Genome-wide pharmacologic unmasking identifies tumor suppressive microRNAs in multiple myeloma

Bi, C., Chung, T. H., Huang, G., Zhou, J., Yan, J., Ahmann, G. J., Fonseca, R. & Chng, W. J., 2015, In : Oncotarget. 6, 28, p. 26508-26518 11 p.

Research output: Contribution to journalArticle

Multiple Myeloma
MicroRNAs
Genome
Neoplasms
Epigenomics
18 Citations (Scopus)

Identification of recurrent truncated DDX3X mutations in chronic lymphocytic leukaemia

Ojha, J., Secreto, C. R., Rabe, K. G., Van Dyke, D. L., Kortum, K. M., Slager, S. L., Shanafelt, T. D., Fonseca, R., Kay, N. E. & Braggio, E. D., May 1 2015, In : British Journal of Haematology. 169, 3, p. 445-448 4 p.

Research output: Contribution to journalArticle

DEAD-box RNA Helicases
B-Cell Chronic Lymphocytic Leukemia
Genomics
Tumor Suppressor Genes
Mutation
22 Citations (Scopus)

Longitudinal analysis of 25 sequential sample-pairs using a custom multiple myeloma mutation sequencing panel (M<sup>3</sup>P)

Kortüm, K. M., Langer, C., Monge, J., Bruins, L., Zhu, Y. X., Shi, C. X., Jedlowski, P., Egan, J. B., Ojha, J., Bullinger, L., Kull, M., Ahmann, G., Rasche, L., Knop, S., Fonseca, R., Einsele, H., Stewart, A. K. & Braggio, E. D., Jul 18 2015, In : Annals of Hematology. 94, 7, p. 1205-1211 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Mutation
Genes
Clonal Evolution
Gene Targeting
37 Citations (Scopus)

Melphalan, prednisone, and thalidomide vs melphalan, prednisone, and lenalidomide (ECOG E1A06) in untreated multiple myeloma

Stewart, A. K., Jacobus, S., Fonseca, R., Weiss, M., Callander, N. S., Chanan Khan, A. A. & Rajkumar, S. V., Sep 10 2015, In : Blood. 126, 11, p. 1294-1301 8 p.

Research output: Contribution to journalArticle

Melphalan
Thalidomide
Oncology
Prednisone
Multiple Myeloma
45 Citations (Scopus)

Phase 2 trial of ixazomib in patients with relapsed multiple myeloma not refractory to bortezomib

Kumar, S. K., Laplant, B., Roy, V., Reeder, C. B., Lacy, M., Gertz, M., Laumann, K., Thompson, M. A., Witzig, T. E., Buadi, F. K., Rivera, C. E., Mikhael, J. R., Bergsagel, P. L., Kapoor, P., Hwa, L., Fonseca, R., Stewart, A. K., Chanan Khan, A. A., Rajkumar, S. V. & Dispenzieri, A., Aug 14 2015, In : Blood Cancer Journal. 4, e338.

Research output: Contribution to journalArticle

Multiple Myeloma
Dexamethasone
Bortezomib
ixazomib
Proteasome Inhibitors
27 Citations (Scopus)

Targeted sequencing using a 47 gene multiple myeloma mutation panel (M3P) in -17p high risk disease

Kortüm, K. M., Langer, C., Monge, J., Bruins, L., Egan, J. B., Zhu, Y. X., Shi, C. X., Jedlowski, P., Schmidt, J., Ojha, J., Bullinger, L., Liebisch, P., Kull, M., Champion, M. D., Van Wier, S., Ahmann, G., Rasche, L., Knop, S., Fonseca, R., Einsele, H. & 2 others, Stewart, A. K. & Braggio, E. D., Feb 1 2015, In : British Journal of Haematology. 168, 4, p. 507-510 4 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Mutation
Genes
53 Citations (Scopus)

Treatment of Immunoglobulin Light Chain Amyloidosis Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Statement

Dispenzieri, A., Buadi, F., Kumar, S. K., Reeder, C. B., Sher, T., Lacy, M., Kyle, R. A., Mikhael, J. R., Roy, V., Leung, N., Grogan, M., Kapoor, P., Lust, J. A., Dingli, D. M., Go, R. S., Hwa, Y. L., Hayman, S. R., Fonseca, R., Ailawadhi, S., Bergsagel, P. L. & 6 others, Chanan Khan, A. A., Rajkumar, S. V., Russell, S. J., Stewart, A. K., Zeldenrust, S. R. & Gertz, M., Aug 1 2015, In : Mayo Clinic Proceedings. 90, 8, p. 1054-1081 28 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Amyloidosis
Consensus
Expert Testimony
Therapeutics
2014
6 Citations (Scopus)

Absence of tissue factor is characteristic of lymphoid malignancies of both T- and B-cell origin

Cesarman-Maus, G., Braggio, E. D., Lome-Maldonado, C., Morales-Leyte, A. L. & Fonseca, R., 2014, In : Thrombosis Research. 133, 4, p. 606-609 4 p.

Research output: Contribution to journalArticle

Thromboplastin
B-Lymphocytes
Neoplasms
Thrombosis
Lymphoma
48 Citations (Scopus)

Activation of TAK1 by MYD88 L265P drives malignant B-cell growth in non-Hodgkin lymphoma

Ansell, S. M., Hodge, L. S., Secreto, F. J., Manske, M., Braggio, E. D., Price-Troska, T., Ziesmer, S., Li, Y., Johnson, S. H., Hart, S., Kocher, J-P., Vasmatzis, G., Chanan Khan, A. A., Gertz, M., Fonseca, R., Dogan, A., Cerhan, J. R. & Novak, A. J., 2014, In : Blood Cancer Journal. 4, 2, 20144.

Research output: Contribution to journalArticle

Waldenstrom Macroglobulinemia
Non-Hodgkin's Lymphoma
B-Lymphocytes
Growth
TNF Receptor-Associated Factor 6
10 Citations (Scopus)

Activity of 129 single-agent drugs in 228 phase i and II clinical trials in multiple myeloma

Kortuem, K. M., Zidich, K., Schuster, S. R., Khan, M. L., Jimenez-Zepeda, V. H., Mikhael, J. R., Fonseca, R. & Stewart, A. K., 2014, In : Clinical Lymphoma, Myeloma and Leukemia. 14, 4, p. 284-290 7 p.

Research output: Contribution to journalArticle

Phase II Clinical Trials
Multiple Myeloma
Pharmaceutical Preparations
fotemustine
Teniposide

Amitriptyline-induced agranulocytosis with bone marrow confirmation

Azadeh, N., Kelemen, K. & Fonseca, R., Oct 1 2014, In : Clinical Lymphoma, Myeloma and Leukemia. 14, 5, p. e183-e185

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
Boronic Acids
Pyrazines
Febrile Neutropenia
Spontaneous Fractures
83 Citations (Scopus)

Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma

Zhu, Y. X., Braggio, E. D., Shi, C. X., Kortuem, K. M., Bruins, L. A., Schmidt, J. E., Chang, X-B. D., Langlais, P. R., Luo, M., Jedlowski, P., LaPlant, B., Laumann, K., Fonseca, R., Bergsagel, P. L., Mikhael, J. R., Lacy, M., Champion, M. D. & Stewart, A. K., Jul 24 2014, In : Blood. 124, 4, p. 536-545 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Carrier Proteins
Survival
Cells
Ports and harbors
38 Citations (Scopus)

Implementing individualized medicine into the medical practice

Lazaridis, K. N., MCAllister, T. M., Babovic-Vuksanovic, D., Beck, S. A., Borad, M. J., Bryce, A. H., Chanan Khan, A. A., Ferber, M. J., Fonseca, R., Johnson, K. J., Klee, E. W., Lindor, N. M., MCCormick, J. B., Mc Williams, R. R., Parker, A., Riegert-Johnson, D. L., Rohrer Vitek, C. R., Schahl, K. A., Schultz, C., Stewart, A. K. & 3 others, Then, G. C., Wieben, E. D. & Farrugia, G., 2014, In : American Journal of Medical Genetics, Part C: Seminars in Medical Genetics. 166, 1, p. 15-23 9 p.

Research output: Contribution to journalArticle

Precision Medicine
Medicine
Patient Care
Exome
Workflow