• 31069 Citations
  • 94 Scopus h-Index
19962020
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Research Output 1996 2019

2010
47 Citations (Scopus)

DNA methylation analysis determines the high frequency of genic hypomethylation and low frequency of hypermethylation events in plasma cell tumors

Salhia, B., Baker, A., Ahmann, G., Auclair, D., Fonseca, R. & Carpten, J. D., Sep 1 2010, In : Cancer Research. 70, 17, p. 6934-6944 11 p.

Research output: Contribution to journalArticle

Plasmacytoma
DNA Methylation
Multiple Myeloma
Plasma Cells
Monoclonal Gammopathy of Undetermined Significance
44 Citations (Scopus)
Multiple Myeloma
Fluorescence In Situ Hybridization
Cytogenetics
Therapeutics
Plasma Cells
72 Citations (Scopus)

Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6

Tiedemann, R. E., Zhu, Y. X., Schmidt, J., Yin, H., Shi, C. X., Que, Q., Basu, G., Azorsa, D., Perkins, L. M., Braggio, E. D., Fonseca, R., Bergsagel, P. L., Mousses, S. & Stewart, A. K., Feb 25 2010, In : Blood. 115, 8, p. 1594-1604 11 p.

Research output: Contribution to journalArticle

RNA Interference
Multiple Myeloma
Phosphotransferases
Tumors
Phosphorylation
99 Citations (Scopus)

Lenalidomide plus dexamethasone versus thalidomide plus dexamethasone in newly diagnosed multiple myeloma: A comparative analysis of 411 patients

Gay, F., Hayman, S. R., Lacy, M., Buadi, F., Gertz, M., Kumar, S. K., Dispenzieri, A., Mikhael, J. R., Bergsagel, P. L., Dingli, D. M., Reeder, C. B., Lust, J. A., Russell, S. J., Roy, V., Zeldenrust, S. R., Witzig, T. E., Fonseca, R., Kyle, R. A., Greipp, P. R., Stewart, A. K. & 1 others, Rajkumar, S. V., Feb 18 2010, In : Blood. 115, 7, p. 1343-1350 8 p.

Research output: Contribution to journalArticle

Thalidomide
Multiple Myeloma
Dexamethasone
Toxicity
lenalidomide
683 Citations (Scopus)

Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trial

Rajkumar, S. V., Jacobus, S., Callander, N. S., Fonseca, R., Vesole, D. H., Williams, M. E., Abonour, R., Siegel, D. S., Katz, M. & Greipp, P. R., Jan 2010, In : The Lancet Oncology. 11, 1, p. 29-37 9 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Dexamethasone
Randomized Controlled Trials
Therapeutics
lenalidomide
77 Citations (Scopus)

Monoclonal gammopathy of undetermined significance: A consensus statement: Guideline

Berenson, J. R., Anderson, K. C., Audell, R. A., Boccia, R. V., Coleman, M., Dimopoulos, M. A., Drake, M. M., Fonseca, R., Harousseau, J. L., Joshua, D., Lonial, S., Niesvizky, R., Palumbo, A., Roodman, G. D., San-Miguel, J. F., Singhal, S., Weber, D. M., Zangari, M., Wirtschafter, E., Yellin, O. & 1 others, Kyle, R. A., Jul 2010, In : British Journal of Haematology. 150, 1, p. 28-38 11 p.

Research output: Contribution to journalArticle

Monoclonal Gammopathy of Undetermined Significance
Guidelines
Paraproteinemias
B-Lymphocytes
Metabolic Bone Diseases
136 Citations (Scopus)

Once- versus twice-weekly bortezomib induction therapy with CyBorD in newly diagnosed multiple myeloma

Reeder, C. B., Reece, D. E., Kukreti, V., Chen, C., Trudel, S., Laumann, K., Hentz, J., Pirooz, N. A., Piza, J. G., Tiedemann, R., Mikhael, J. R., Bergsagel, P. L., Leis, J. F., Fonseca, R. & Stewart, A. K., Apr 22 2010, In : Blood. 115, 16, p. 3416-3417 2 p.

Research output: Contribution to journalArticle

Boronic Acids
Pyrazines
Cyclophosphamide
Dexamethasone
Bortezomib

Plasma cell neoplasms

Fonseca, R. & Valdez, R., Jan 1 2010, Diagnostic Techniques in Hematological Malignancies. Cambridge University Press, Vol. 9780521111218. p. 244-265 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Plasma Cell Neoplasms
Multiple Myeloma
Monoclonal Gammopathy of Undetermined Significance
Plasma Cells
Plasma Cell Leukemia
161 Citations (Scopus)

Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM)

Lacy, M., Hayman, S. R., Gertz, M., Short, K. D., Dispenzieri, A., Kumar, S. K., Greipp, P. R., Lust, J. A., Russell, S. J., Dingli, D. M., Zeldenrust, S., Fonseca, R., Bergsagel, P. L., Roy, V., Mikhael, J. R., Stewart, A. K., Laumann, K., Allred, J. B., Mandrekar, S. J., Rajkumar, S. V. & 1 others, Buadi, F., Nov 23 2010, In : Leukemia. 24, 11, p. 1934-1939 6 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Dexamethasone
Neutropenia
Thrombocytopenia
pomalidomide
201 Citations (Scopus)

Prevalence and risk of progression of light-chain monoclonal gammopathy of undetermined significance: a retrospective population-based cohort study

Dispenzieri, A., Katzmann, J. A., Kyle, R. A., Larson, D. R., Melton, L. J., Colby, C. L., Therneau, T. M., Clark, R., Kumar, S. K., Bradwell, A., Fonseca, R., Jelinek, D. F. & Rajkumar, S. V., 2010, In : The Lancet. 375, 9727, p. 1721-1728 8 p.

Research output: Contribution to journalArticle

Monoclonal Gammopathy of Undetermined Significance
Cohort Studies
Light
Population
Multiple Myeloma
33 Citations (Scopus)

Primary therapy with single agent bortezomib as induction, maintenance and re-induction in patients with high-risk myeloma: Results of the ECOG E2A02 trial

Dispenzieri, A., Jacobus, S., Vesole, D. H., Callandar, N., Fonseca, R. & Greipp, P. R., Aug 2010, In : Leukemia. 24, 8, p. 1406-1411 6 p.

Research output: Contribution to journalArticle

Maintenance
Confidence Intervals
Multiple Myeloma
Therapeutics
Neuralgia
30 Citations (Scopus)

Progressive but previously untreated CLL patients with greater array CGH complexity exhibit a less durable response to chemoimmunotherapy

Kay, N. E., Eckel-Passow, J. E., Braggio, E. D., VanWier, S., Shanafelt, T. D., Van Dyke, D. L., Jelinek, D. F., Tschumper, R. C., Kipps, T., Byrd, J. C. & Fonseca, R., Dec 2010, In : Cancer Genetics and Cytogenetics. 203, 2, p. 161-168 8 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Comparative Genomic Hybridization
Chromosomes, Human, Pair 8
Chromosomes, Human, Pair 3
Genomic Instability
21 Citations (Scopus)

Relationship between elevated immunoglobulin free light chain and the presence of IgH translocations in multiple myeloma

Kumar, S. K., Zhang, L., Dispenzieri, A., Van Wier, S., Katzmann, J. A., Snyder, M., Blood, E., Degoey, R., Henderson, K., Kyle, R. A., Bradwell, A. R., Greipp, P. R., Rajkumar, S. V. & Fonseca, R., Aug 2010, In : Leukemia. 24, 8, p. 1498-1505 8 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Multiple Myeloma
Light
Cytogenetic Analysis
Fluorescence In Situ Hybridization
45 Citations (Scopus)

Treatment with bortezomib of a patient having hyper IgG4 disease

Khan, M. L., Colby, T. V., Viggiano, R. W. & Fonseca, R., Jun 2010, In : Clinical Lymphoma, Myeloma and Leukemia. 10, 3, p. 217-219 3 p.

Research output: Contribution to journalArticle

Immunoglobulin G
Complementary Therapies
Plasma Cells
Multiple Myeloma
Adrenal Cortex Hormones
2009
13 Citations (Scopus)

Centrosomes and myeloma; aneuploidy and proliferation

Chng, W. J. & Fonseca, R., Oct 2009, In : Environmental and Molecular Mutagenesis. 50, 8, p. 697-707 11 p.

Research output: Contribution to journalArticle

Centrosome
Aneuploidy
Genomic Instability
Plasma Cells
Hypercalcemia
266 Citations (Scopus)

Cyclophosphamide, bortezomib and dexamethasone induction for newly diagnosed multiple myeloma: High response rates in a phase II clinical trial

Reeder, C. B., Reece, D. E., Kukreti, V., Chen, C., Trudel, S., Hentz, J., Noble, B., Pirooz, N. A., Spong, J. E., Piza, J. G., Zepeda, V. H. J., Mikhael, J. R., Leis, J. F., Bergsagel, P. L., Fonseca, R. & Stewart, A. K., 2009, In : Leukemia. 23, 7, p. 1337-1341 5 p.

Research output: Contribution to journalArticle

Phase II Clinical Trials
Multiple Myeloma
Cyclophosphamide
Dexamethasone
Stem Cell Transplantation
29 Citations (Scopus)

Gene expression profiling of pulmonary mucosa-associated lymphoid tissue lymphoma identifies new biologic insights with potential diagnostic and therapeutic applications

Chng, W. J., McPhail, E., Fonseca, R., Bergsagel, P. L., Vrana, J. A., Kurtin, P. J. & Dogan, A., Jan 15 2009, In : Blood. 113, 3, p. 635-645 11 p.

Research output: Contribution to journalArticle

Marginal Zone B-Cell Lymphoma
Gene Expression Profiling
Gene expression
Lymphoid Tissue
Genes
24 Citations (Scopus)

High-resolution genomic analysis in Waldenström's macroglobulinemia identifies disease-specific and common abnormalities with marginal zone lymphomas

Braggio, E. D., Keats, J., Leleu, X., Wier, S. V., Jimenez-Zepeda, V. H., Schop, R., Chesi, M., Barrett, M., Stewart, A. K., Dogan, A., Bergsagel, P. L., Ghobrial, I. & Fonseca, R., 2009, In : Clinical Lymphoma and Myeloma. 9, 1, p. 39-42 4 p.

Research output: Contribution to journalArticle

Waldenstrom Macroglobulinemia
Lymphoma
Chromosome Aberrations
Comparative Genomic Hybridization
Cytogenetic Analysis
107 Citations (Scopus)

Identification of copy number abnormalities and inactivating mutations in two negative regulators of nuclear factor-κB signaling pathways in Waldenström's macroglobulinemia

Braggio, E. D., Keats, J. J., Leleu, X., Van Wier, S., Jimenez-Zepeda, V. H., Valdez, R., Schop, R. F. J., Price-Troska, T., Henderson, K., Sacco, A., Azab, F., Greipp, P., Gertz, M., Hayman, S., Rajkumar, S. V., Carpten, J., Chesi, M., Barrett, M., Stewart, A. K., Dogan, A. & 3 others, Bergsagel, P. L., Ghobrial, I. M. & Fonseca, R., Apr 15 2009, In : Cancer Research. 69, 8, p. 3579-3588 10 p.

Research output: Contribution to journalArticle

Waldenstrom Macroglobulinemia
Mutation
Bone Marrow
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Uniparental Disomy
108 Citations (Scopus)

Impact of risk stratification on outcome among patients with multiple myeloma receiving initial therapy with lenalidomide and dexamethasone

Kapoor, P., Kumar, S. K., Fonseca, R., Lacy, M., Witzig, T. E., Hayman, S. R., Dispenzieri, A., Buadi, F., Bergsagel, P. L., Gertz, M., Dalton, R. J., Mikhael, J. R., Dingli, D. M., Reeder, C. B., Lust, J. A., Russell, S. J., Roy, V., Zeldenrust, S. R., Stewart, A. K., Kyle, R. A. & 2 others, Greipp, P. R. & Rajkumar, S. V., 2009, In : Blood. 114, 3, p. 518-521 4 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Dexamethasone
Plasma Cells
Plasmas
Labeling
553 Citations (Scopus)

International Myeloma Working Group molecular classification of multiple myeloma: Spotlight review

Fonseca, R., Bergsagel, P. L., Drach, J., Shaughnessy, J., Gutierrez, N., Stewart, A. K., Morgan, G., Van Ness, B., Chesi, M., Minvielle, S., Neri, A., Barlogie, B., Kuehl, W. M., Liebisch, P., Davies, F., Chen-Kiang, S., Durie, B. G. M., Carrasco, R., Sezer, O., Reiman, T. & 2 others, Pilarski, L. & Avet-Loiseau, H., Dec 2009, In : Leukemia. 23, 12, p. 2210-2221 12 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Polyploidy
Genetic Testing
Chromosomes, Human, Pair 13
Chromosomes, Human, Pair 17
2 Citations (Scopus)

La genética como factor pronóstico y terapéutico en el mieloma múltiple

Translated title of the contribution: Genetic markers as prognostic factors in multiple myelomaConte L., G., Braggio, E. D., Figueroa, G. & Fonseca, R., Apr 2009, In : Revista Medica de Chile. 137, 4, p. 552-558 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Genetic Markers
Chromosomes, Human, Pair 13
Chromosome Deletion
Cytogenetic Analysis
192 Citations (Scopus)

Management of newly diagnosed symptomatic multiple myeloma: Updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus guidelines

Kumar, S. K., Mikhael, J. R., Buadi, F. K., Dingli, D. M., Dispenzieri, A., Fonseca, R., Gertz, M., Greipp, P. R., Hayman, S. R., Kyle, R. A., Lacy, M., Lust, J. A., Reeder, C. B., Roy, V., Russell, S. J., Detweiler Short, K. E., Stewart, A. K., Witzig, T. E., Zeldenrust, S. R., Dalton, R. J. & 2 others, Rajkumar, S. V. & Bergsagel, P. L., 2009, In : Mayo Clinic Proceedings. 84, 12, p. 1095-1110 16 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Guidelines
Plasma Cell Neoplasms
Therapeutics
Hematologic Neoplasms
246 Citations (Scopus)

Pomalidomide (CC4047) plus low-dose dexamethasone as therapy for relapsed multiple myeloma

Lacy, M., Hayman, S. R., Gertz, M., Dispenzieri, A., Buadi, F., Kumar, S. K., Greipp, P. R., Lust, J. A., Russell, S. J., Dingli, D. M., Kyle, R. A., Fonseca, R., Bergsagel, P. L., Roy, V., Mikhael, J. R., Stewart, A. K., Laumann, K., Allred, J. B., Mandrekar, S. J. & Rajkumar, S. V., Oct 20 2009, In : Journal of Clinical Oncology. 27, 30, p. 5008-5014 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Dexamethasone
Therapeutics
Thalidomide
pomalidomide
3 Citations (Scopus)

Spontaneous remission in a patient with t(4;14) translocation multiple myeloma

Puig, N., Trudel, S., Keats, J. J., Li, Z. H., Braggio, E. D., Ahmann, G. J., Zeng, S., Fonseca, R. & Kukreti, V., Nov 20 2009, In : Journal of Clinical Oncology. 27, 33

Research output: Contribution to journalArticle

Neoplastic Gene Expression Regulation
Severity of Illness Index
Bence Jones Protein
Spontaneous Remission
Chromosomes, Human, Pair 14
63 Citations (Scopus)

Translocation t(11;14) and survival of patients with light chain (AL) amyloidosis

Bryce, A. H., Ketterling, R. P., Gertz, M., Lacy, M., Knudson, R. A., Zeldenrust, S., Kumar, S. K., Hayman, S., Buadi, F., Kyle, R. A., Greipp, P. R., Lust, J. A., Russell, S. J., Rajkumar, S. V., Fonseca, R. & Dispenzieri, A., Mar 2009, In : Haematologica. 94, 3, p. 380-386 7 p.

Research output: Contribution to journalArticle

Amyloidosis
Fluorescence In Situ Hybridization
Light
Survival
Plasma Cells
2008
4 Citations (Scopus)

Acute myocardial infarction: An unusual presentation of essential thrombocytosis in a 17-year-old man

Kelly, S. V., Burke, R. F., Lee, K. S., Torloni, A. S., Lee, R. W., Northfelt, D. W. & Fonseca, R., Feb 2008, In : Clinical Advances in Hematology and Oncology. 6, 2, p. 133-136 4 p.

Research output: Contribution to journalArticle

Nucleic Acid Synthesis Inhibitors
Essential Thrombocythemia
Thrombocytosis
Hydroxyurea
Platelet Count
206 Citations (Scopus)

AID-Dependent Activation of a MYC Transgene Induces Multiple Myeloma in a Conditional Mouse Model of Post-Germinal Center Malignancies

Chesi, M., Robbiani, D. F., Sebag, M., Chng, W. J., Affer, M., Tiedemann, R., Valdez, R., Palmer, S. E., Haas, S. S., Stewart, A. K., Fonseca, R., Kremer, R., Cattoretti, G. & Bergsagel, P. L., Feb 5 2008, In : Cancer Cell. 13, 2, p. 167-180 14 p.

Research output: Contribution to journalArticle

Germinal Center
Multiple Myeloma
Transgenes
Paraproteinemias
Monoclonal Gammopathy of Undetermined Significance
12 Citations (Scopus)

A novel report of cIg-FISH and cytogenetics in POEMS syndrome

Bryce, A. H., Ketterling, R. P., Gertz, M., Lacy, M., Knudson, R. A., Kumar, S. K., Kyle, R. A., Fonseca, R., Greipp, P. R., Lust, J. A., Rajkumar, S. V., Hayman, S. R., Buadi, F., Russell, S. J., Zeldenrust, S. R. & Dispenzieri, A., Nov 2008, In : American Journal of Hematology. 83, 11, p. 840-841 2 p.

Research output: Contribution to journalArticle

POEMS Syndrome
Cytogenetics
Monosomy
Immunoglobulins
Plasma Cells
44 Citations (Scopus)

Biologic and genetic characterization of the novel amyloidogenic lambda light chain-secreting human cell lines, ALMC-1 and ALMC-2

Arendt, B. K., Ramirez-Alvarado, M., Sikkink, L. A., Keats, J. J., Ahmann, G. J., Dispenzieri, A., Fonseca, R., Ketterling, R. P., Knudson, R. A., Mulvihill, E. M., Tschumper, R. C., Wu, X., Zeldenrust, S. R. & Jelinek, D. F., Sep 1 2008, In : Blood. 112, 5, p. 1931-1941 11 p.

Research output: Contribution to journalArticle

Cells
Light
Cell Line
Amyloid
Amyloidosis
2 Citations (Scopus)

Cell lines of hyperdiploid myeloma, are we there yet? [2]

Chng, W. J. & Fonseca, R., Mar 2008, In : British Journal of Haematology. 140, 5, p. 579-580 2 p.

Research output: Contribution to journalArticle

Polyploidy
Comparative Genomic Hybridization
Tumor Cell Line
Diploidy
Multiple Myeloma
101 Citations (Scopus)

Clinical and biological significance of RAS mutations in multiple myeloma

Chng, W. J., Gonzalez-Paz, N., Price-Troska, T., Jacobus, S., Rajkumar, S. V., Oken, M. M., Kyle, R. A., Henderson, K. J., Van Wier, S., Greipp, P., Van Ness, B. & Fonseca, R., 2008, In : Leukemia. 22, 12, p. 2280-2284 5 p.

Research output: Contribution to journalArticle

Neoplastic Cell Transformation
ras Genes
Multiple Myeloma
Mutation
21 Citations (Scopus)

Comparison of Twin and Autologous Transplants for Multiple Myeloma

Bashey, A., Pérez, W. S., Zhang, M. J., Anderson, K. C., Ballen, K., Berenson, J. R., To, L. B., Fonseca, R., Freytes, C. O., Gale, R. P., Gibson, J., Giralt, S. A., Kyle, R. A., Lazarus, H. M., Maharaj, D., McCarthy, P. L., Milone, G. A., Nimer, S., Pavlovsky, S., Reece, D. E. & 3 others, Schiller, G., Vesole, D. H. & Hari, P., Oct 2008, In : Biology of Blood and Marrow Transplantation. 14, 10, p. 1118-1124 7 p.

Research output: Contribution to journalArticle

Autografts
Multiple Myeloma
Transplants
Recurrence
Multivariate Analysis
105 Citations (Scopus)

Compromised stem cell mobilization following induction therapy with lenalidomide in myeloma

Paripati, H., Stewart, A. K., Cabou, S., Dueck, A., Zepeda, V. J., Pirooz, N., Ehlenbeck, C., Reeder, C., Slack, J. L., Leis, J. F., Boesiger, J., Torloni, A. S., Fonseca, R. & Bergsagel, P. L., Jun 2008, In : Leukemia. 22, 6, p. 1282-1284 3 p.

Research output: Contribution to journalArticle

Antineoplastic Combined Chemotherapy Protocols
Hematopoietic Stem Cell Mobilization
Peripheral Blood Stem Cell Transplantation
Remission Induction
Combined Modality Therapy
10 Citations (Scopus)
Multiple Myeloma
Dexamethasone
Proteasome Inhibitors
Clinical Trials
Thalidomide
2 Citations (Scopus)

Diagnosis and genetic classification of multiple myeloma

Fonseca, R. & Bergsagel, P. L., Jan 1 2008, Treatment of Multiple Myeloma and Related Disorders. Cambridge University Press, Vol. 9780521515030. p. 1-17 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Multiple Myeloma
Clonal Evolution
Genetic Techniques
Polyploidy
Cytogenetic Analysis
3 Citations (Scopus)
Chromosomes, Human, Pair 14
beta 2-Microglobulin
Genetic Translocation
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 4
13 Citations (Scopus)

Effect of tissue shipping on plasma cell isolation, viability, and RNA integrity in the context of a centralized good laboratory practice-certified tissue banking facility

Ahmann, G. J., Wee, J. C., Henderson, K. J., Price-Troska, T. L., DeGoey, R. W., Timm, M. M., Dispenzieri, A., Greipp, P. R., Sable-Hunt, A., Bergsagel, P. L. & Fonseca, R., Mar 2008, In : Cancer Epidemiology Biomarkers and Prevention. 17, 3, p. 666-673 8 p.

Research output: Contribution to journalArticle

Tissue Banks
Cell Separation
Plasma Cells
Multiple Myeloma
Cell Survival
Leukemia

Erratum: Expression and mutation status of candidate kinases in multiple myeloma (Leukemia (2007) vol. 21 (1124-1127) 10.1038/sj.leu.2404612)

Claudio, J. O., Zhan, F., Zhuang, L., Khaja, R., Zhu, Y. X., Sivananthan, K., Trudel, S., Masih-Khan, E., Fonseca, R., Bergsagel, P. L., Scherer, S. W., Shaughnessy, J. & Stewart, A. K., Apr 2008, In : Leukemia. 22, 4, p. 889-890 2 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Leukemia
Phosphotransferases
Mutation
192 Citations (Scopus)

Genetic aberrations and survival in plasma cell leukemia

Tiedemann, R. E., Gonzalez-Paz, N., Kyle, R. A., Santana-Davila, R., Price-Troska, T., Van Wier, S. A., Chng, W. J., Ketterling, R. P., Gertz, M., Henderson, K., Greipp, P. R., Dispenzieri, A., Lacy, M., Rajkumar, S. V., Bergsagel, P. L., Stewart, A. K. & Fonseca, R., May 2008, In : Leukemia. 22, 5, p. 1044-1052 9 p.

Research output: Contribution to journalArticle

Plasma Cell Leukemia
Multiple Myeloma
Survival
Tumor Suppressor Protein p14ARF
Mutation
44 Citations (Scopus)

Identification of kinetin riboside as a repressor of CCND1 and CCND2 with preclinical antimyeloma activity

Tiedemann, R. E., Mao, X., Shi, C. X., Yuan, X. Z., Palmer, S. E., Sebag, M., Marler, R. J., Chesi, M., Fonseca, R., Bergsagel, P. L., Schimmer, A. D. & Stewart, A. K., May 1 2008, In : Journal of Clinical Investigation. 118, 5, p. 1750-1764 15 p.

Research output: Contribution to journalArticle

Cyclin D
Cyclin D2
Neoplasms
bcl-1 Genes
Small Molecule Libraries
272 Citations (Scopus)

Immunoglobulin free light chain ratio is an independent risk factor for progression of smoldering (asymptomatic) multiple myeloma

Dispenzieri, A., Kyle, R. A., Katzmann, J. A., Therneau, T. M., Larson, D., Benson, J., Clark, R. J., Melton, L. J., Gertz, M., Kumar, S. K., Fonseca, R., Jelinek, D. F. & Rajkumar, S. V., Jan 15 2008, In : Blood. 111, 2, p. 785-789 5 p.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Plasma Cells
Multiple Myeloma
Bone Marrow Cells
Immunoglobulins
58 Citations (Scopus)

Long-term results of the treatment of patients with mantle cell lymphoma with cladribine (2-CDA) alone (95-80-53) or 2-CDA and rituximab (N0189) in the North Central Cancer Treatment Group

Inwards, D. J., Fishkin, P. A. S., Hillman, D. W., Brown, D. W., Ansell, S. M., Kurtin, P. J., Fonseca, R., Morton, R. F., Veeder, M. H. & Witzig, T. E., Jul 1 2008, In : Cancer. 113, 1, p. 108-116 9 p.

Research output: Contribution to journalArticle

Cladribine
Mantle-Cell Lymphoma
Neoplasms
Therapeutics
Rituximab
121 Citations (Scopus)

Myeloma in patients younger than age 50 years presents with more favorable features and shows better survival: An analysis of 10 549 patients from the International Myeloma Working Group

Ludwig, H., Durie, B. G. M., Bolejack, V., Turesson, I., Kyle, R. A., Blade, J., Fonseca, R., Dimopoulos, M., Shimizu, K., Miguel, J. S., Westin, J., Harousseau, J. L., Beksac, M., Boccadoro, M., Palumbo, A., Barlogie, B., Shustik, C., Cavo, M., Greipp, P. R., Joshua, D. & 3 others, Attal, M., Sonneveld, P. & Crowley, J., Apr 15 2008, In : Blood. 111, 8, p. 4039-4047 9 p.

Research output: Contribution to journalArticle

Survival Analysis
C-Reactive Protein
Autologous Transplantation
Creatinine
Hemoglobins
138 Citations (Scopus)

Phase I, pharmacokinetic and pharmacodynamic study of the anti-insulinlike growth factor type 1 receptor monoclonal antibody CP-751,871 in patients with multiple myeloma

Lacy, M., Alsina, M., Fonseca, R., Paccagnella, M. L., Melvin, C. L., Yin, D., Sharma, A., Sarano, M. E., Pollak, M., Jagannath, S., Richardson, P. & Gualberto, A., 2008, In : Journal of Clinical Oncology. 26, 19, p. 3196-3203 8 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Multiple Myeloma
Pharmacokinetics
Monoclonal Antibodies
Dexamethasone
83 Citations (Scopus)

The centrosome index is a powerful prognostic marker in myeloma and identifies a cohort of patients that might benefit from aurora kinase inhibition

Chng, W. J., Braggio, E. D., Mulligan, G., Bryant, B., McPhail, E., Valdez, R., Dogan, A. & Fonseca, R., 2008, In : Blood. 111, 3, p. 1603-1609 7 p.

Research output: Contribution to journalArticle

Aurora Kinases
Centrosome
Amplification
Cells
Gene expression
25 Citations (Scopus)

Translocation t(4;14) retains prognostic significance even in the setting of high-risk molecular signature [16]

Chng, W. J., Kuehl, W. M., Bergsagel, P. L. & Fonseca, R., Feb 2008, In : Leukemia. 22, 2, p. 459-461 3 p.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 14
Genetic Translocation
Chromosomes, Human, Pair 4
Gene Expression Profiling
Survival Analysis
2007
78 Citations (Scopus)

6q deletion in Waldenström macroglobulinemia is associated with features of adverse prognosis

Ocio, E. M., Schop, R. F. J., Gonzalez, B., Van Wier, S. A., Hernandez-Rivas, J. M., Gutierrez, N. C., Garcia-Sanz, R., Moro, M. J., Aguilera, C., Hernandez, J., Xu, R., Greipp, P. R., Dispenzieri, A., Jalal, S. M., Lacy, M., Gonzalez-Paz, N., Gertz, M., San Miguel, J. F. & Fonseca, R., Jan 2007, In : British Journal of Haematology. 136, 1, p. 80-86 7 p.

Research output: Contribution to journalArticle

Waldenstrom Macroglobulinemia
Fluorescence In Situ Hybridization
Cytogenetics
Paraproteins
Hypoalbuminemia
163 Citations (Scopus)

A practical guide to defining high-risk myeloma for clinical trials, patient counseling and choice of therapy

Stewart, A. K., Bergsagel, P. L., Greipp, P. R., Dispenzieri, A., Gertz, M., Hayman, S. R., Kumar, S. K., Lacy, M., Lust, J. A., Russell, S. J., Witzig, T. E., Zeldenrust, S. R., Dingli, D. M., Reeder, C. B., Roy, V., Kyle, R. A., Rajkumar, S. V. & Fonseca, R., Mar 2007, In : Leukemia. 21, 3, p. 529-534 6 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Counseling
Clinical Trials
Therapeutics
Chromosomes, Human, Pair 13