• 31787 Citations
  • 96 Scopus h-Index
19962020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

2005

A "not so micro" model for a "macro" problem

Fonseca, R., Aug 15 2005, In : Blood. 106, 4, p. 1143-1144 2 p.

Research output: Contribution to journalComment/debate

Open Access

A phase 1 study of 153Sm-EDTMP with fixed high-dose melphalan as a peripheral blood stem cell conditioning regimen in patients with multiple myeloma

Dispenzieri, A., Wiseman, G. A., Lacy, M. Q., Litzow, M. R., Anderson, P. M., Gastineau, D. A., Tefferi, A., Inwards, D. J., Micallef, I. N. M., Ansell, S. M., Porrata, L., Elliot, M. A., Lust, J. A., Greipp, P. R., Rajkumar, S. V., Fonseca, R., Witzig, T. E., Erlichman, C., Sloan, J. A. & Gertz, M. A., Jan 2005, In : Leukemia. 19, 1, p. 118-125 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

A validated FISH trisomy index demonstrates the hyperdiploid and nonhyperdiploid dichotomy in MGUS

Chng, W. J., Van Wier, S. A., Ahmann, G. J., Winkler, J. M., Jalal, S. M., Bergsagel, P. L., Chesi, M., Trendle, M. C., Oken, M. M., Blood, E., Henderson, K., Santana-Dávila, R., Kyle, R. A., Gertz, M. A., Lacy, M. Q., Dispenzieri, A., Greipp, P. R. & Fonseca, R., Sep 15 2005, In : Blood. 106, 6, p. 2156-2161 6 p.

Research output: Contribution to journalArticle

103 Scopus citations

Clinical implications of t(11;14)(q13;q32), t(4;14)(p16.3;q32), and -17p13 in myeloma patients treated with high-dose therapy

Gertz, M. A., Lacy, M. Q., Dispenzieri, A., Greipp, P. R., Litzow, M. R., Henderson, K. J., Van Wier, S. A., Ahmann, G. J. & Fonseca, R., Oct 1 2005, In : Blood. 106, 8, p. 2837-2840 4 p.

Research output: Contribution to journalArticle

284 Scopus citations

Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma

Rajkumar, S. V., Hayman, S. R., Lacy, M. Q., Dispenzieri, A., Geyer, S. M., Kabat, B., Zeldenrust, S. R., Kumar, S., Greipp, P. R., Fonseca, R., Lust, J. A., Russell, S. J., Kyle, R. A., Witzig, T. E. & Gertz, M. A., Dec 15 2005, In : Blood. 106, 13, p. 4050-4053 4 p.

Research output: Contribution to journalArticle

532 Scopus citations
24 Scopus citations

Detection of chromosome 13 deletions by fluorescent in situ hybridization.

VanWier, S. & Fonseca, R., 2005, In : Methods in molecular medicine. 113, p. 59-69 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis

Fernandez-Zapico, M. E., Gonzalez-Paz, N. C., Weiss, E., Savoy, D. N., Molina, J. R., Fonseca, R., Smyrk, T. C., Chari, S. T., Urrutia, R. & Billadeau, D. D., Jan 1 2005, In : Cancer cell. 7, 1, p. 39-49 11 p.

Research output: Contribution to journalArticle

149 Scopus citations

Functional gene expression analysis of clonal plasma cells identifies a unique molecular profile for light chain amyloidosis

Abraham, R. S., Ballman, K. V., Dispenzieri, A., Grill, D. E., Manske, M. K., Price-Troska, T. L., Paz, N. G., Gertz, M. A. & Fonseca, R., Jan 15 2005, In : Blood. 105, 2, p. 794-803 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Genetics of multiple myeloma

Higgins, M. J. & Fonseca, R., Dec 2005, In : Best Practice and Research: Clinical Haematology. 18, 4 SPEC. ISS., p. 525-536 12 p.

Research output: Contribution to journalReview article

13 Scopus citations

Genomics in multiple myeloma: Biology and clinical implications

Chng, W. J. & Fonseca, R., Sep 1 2005, In : Pharmacogenomics. 6, 6, p. 563-573 11 p.

Research output: Contribution to journalReview article

10 Scopus citations

Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma

Witzig, T. E., Geyer, S. M., Ghobrial, I., Inwards, D. J., Fonseca, R., Kurtin, P., Ansell, S. M., Luyun, R., Flynn, P. J., Morton, R. F., Dakhil, S. R., Gross, H. & Kaufmann, S. H., Dec 1 2005, In : Journal of Clinical Oncology. 23, 23, p. 5347-5356 10 p.

Research output: Contribution to journalArticle

448 Scopus citations

Primary plasma cell leukemia: Report of 17 new cases treated with autologous or allogeneic stem-cell transplantation and review of the literature

Saccaro, S., Fonseca, R., Veillon, D. M., Cotelingam, J., Nordberg, M. L., Bredeson, C., Glass, J. & Munker, R., Apr 1 2005, In : American journal of hematology. 78, 4, p. 288-294 7 p.

Research output: Contribution to journalReview article

74 Scopus citations

Prognostic and therapeutic significance of myeloma genetics and gene expression profiling

Stewart, A. K. & Fonseca, R., Dec 1 2005, In : Journal of Clinical Oncology. 23, 26, p. 6339-6344 6 p.

Research output: Contribution to journalReview article

107 Scopus citations

Prognostic value of circulating plasma cells in monoclonal gammopathy of undetermined significance

Kumar, S., Rajkumar, S. V., Kyle, R. A., Lacy, M. Q., Dispenzieri, A., Fonseca, R., Lust, J. A., Gertz, M. A., Greipp, P. R. & Witzig, T. E., Dec 1 2005, In : Journal of Clinical Oncology. 23, 24, p. 5668-5674 7 p.

Research output: Contribution to journalArticle

85 Scopus citations

Relationship of patient survival and chromosome anomalies detected in metaphase and/or interphase cells at diagnosis of myeloma

Dewald, G. W., Therneau, T., Larson, D., You, K. L., Fink, S., Smoley, S., Paternoster, S., Adeyinka, A., Ketterling, R., Van Dyke, D. L., Fonseca, R. & Kyle, R., Nov 15 2005, In : Blood. 106, 10, p. 3553-3558 6 p.

Research output: Contribution to journalArticle

111 Scopus citations
6 Scopus citations
2006

6q deletion discriminates Waldenström macroglobulinemia from IgM monoclonal gammopathy of undetermined significance

Schop, R. F. J., Van Wier, S. A., Xu, R., Ghobrial, I., Ahmann, G. J., Greipp, P. R., Kyle, R. A., Dispenzieri, A., Lacy, M. Q., Rajkumar, S. V., Gertz, M. A. & Fonseca, R., Sep 1 2006, In : Cancer Genetics and Cytogenetics. 169, 2, p. 150-153 4 p.

Research output: Contribution to journalArticle

77 Scopus citations

Analysis of genetic abnormalities provides insights into genetic evolution of hyperdiploid myeloma

Chng, W. J., Ketterling, R. P. & Fonseca, R., Dec 1 2006, In : Genes Chromosomes and Cancer. 45, 12, p. 1111-1120 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

A phase II trial of imatinib in patients with refractory/relapsed myeloma

Dispenzieri, A., Gertz, M. A., Lacy, M. Q., Geyer, S. M., Greipp, P. R., Rajkumar, S. V., Kimlinger, T., Lust, J. A., Fonseca, R., Allred, J. & Witzig, T. E., Jan 1 2006, In : Leukemia and Lymphoma. 47, 1, p. 39-42 4 p.

Research output: Contribution to journalArticle

34 Scopus citations

Clinical implication of centrosome amplification in plasma cell neoplasm

Chng, W. J., Ahmann, G. J., Henderson, K., Santana-Davila, R., Greipp, P. R., Gertz, M. A., Lacy, M. Q., Dispenzieri, A., Kumar, S., Rajkumar, S. V., Lust, J. A., Kyle, R. A., Zeldenrust, S. R., Hayman, S. R. & Fonseca, R., May 1 2006, In : Blood. 107, 9, p. 3669-3675 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Flavopiridol in patients with relapsed or refractory multiple myeloma: A phase 2 trial with clinical and pharmacodynamic end-points

Dispenzieri, A., Gertz, M. A., Lacy, M. Q., Geyer, S. M., Fitch, T. R., Fenton, R. G., Fonseca, R., Isham, C. R., Ziesmer, S. C., Erlichman, C. & Bible, K. C., Mar 1 2006, In : Haematologica. 91, 3, p. 390-393 4 p.

Research output: Contribution to journalArticle

39 Scopus citations

Gene-expression profiling of Waldenström macroglobulinemia reveals a phenotype more similar to chronic lymphocytic leukemia than multiple myeloma

Chng, W. J., Schop, R. F., Price-Troska, T., Ghobrial, I., Kay, N., Jelinek, D. F., Gertz, M. A., Dispenzieri, A., Lacy, M., Kyle, R. A., Greipp, P. R., Tschumper, R. C., Fonseca, R. & Bergsagel, P. L., Oct 15 2006, In : Blood. 108, 8, p. 2755-2763 9 p.

Research output: Contribution to journalArticle

125 Scopus citations

IGF-1R is overexpressed in poor-prognostic subtypes of multiple myeloma [18]

Chng, W. J., Gualberto, A. & Fonseca, R., Jan 2006, In : Leukemia. 20, 1, p. 174-176 3 p.

Research output: Contribution to journalLetter

35 Scopus citations

Mayo Clinic consensus statement for the use of bisphosphonates in multiple myeloma

Lacy, M. Q., Dispenzieri, A., Gertz, M. A., Greipp, P. R., Gollbach, K. L., Hayman, S. R., Kumar, S., Lust, J. A., Rajkumar, S. V., Russell, S. J., Witzig, T. E., Zeldenrust, S. R., Dingli, D., Bergsagel, P. L., Fonseca, R., Reeder, C. B., Stewart, A. K., Roy, V., Dalton, R. J., Carr, A. B. & 4 others, Kademani, D., Keller, E. E., Viozzi, C. F. & Kyle, R. A., Aug 2006, In : Mayo Clinic proceedings. 81, 8, p. 1047-1053 7 p.

Research output: Contribution to journalArticle

198 Scopus citations

Natural history of thromboembolism in AL amyloidosis

Halligan, C. S., Lacy, M. Q., Rajkumar, S. V., Dispenzieri, A., Witzig, T. E., Lust, J. A., Fonseca, R., Gertz, M. A., Kyle, R. A. & Pruthi, R. K., Mar 1 2006, In : Amyloid. 13, 1, p. 31-36 6 p.

Research output: Contribution to journalArticle

23 Scopus citations
758 Scopus citations

Ploidy status rarely changes in myeloma patients at disease progression

Chng, W. J., Winkler, J. M., Greipp, P. R., Jalal, S. M., Bergsagel, P. L., Chesi, M., Trendle, M. C., Ahmann, G. J., Henderson, K., Blood, E., Oken, M. M., Hulbert, A., Wier, S. A. V., Santana-Dávila, R., Kyle, R. A., Gertz, M. A., Lacy, M. Q., Dispenzieri, A. & Fonseca, R., Mar 1 2006, In : Leukemia Research. 30, 3, p. 266-271 6 p.

Research output: Contribution to journalArticle

30 Scopus citations

Prognostic factors for hyperdiploid-myeloma: Effects of chromosome 13 deletions and IgH translocations

Chng, W. J., Santana-Dávila, R., Van Wier, S. A., Ahmann, G. J., Jalal, S. M., Bergsagel, P. L., Chesi, M., Trendle, M. C., Jacobus, S., Blood, E., Oken, M. M., Henderson, K., Kyle, R. A., Gertz, M. A., Lacy, M. Q., Dispenzieri, A., Greipp, P. R. & Fonseca, R., May 2006, In : Leukemia. 20, 5, p. 807-813 7 p.

Research output: Contribution to journalArticle

107 Scopus citations

Prognostic model for disease-specific and overall mortality in newly diagnosed symptomatic patients with Waldenstrom macroglobulinaemia

Ghobrial, I. M., Fonseca, R., Gertz, M. A., Plevak, M. F., Larson, D. R., Therneau, T. M., Wolf, R. C., Hoffmann, R. J., Lust, J. A., Witzig, T. E., Lacy, M. Q., Dispenzieri, A., Rajkumar, V. S., Zeldenrust, S. R., Greipp, P. R. & Kyle, R. A., Apr 1 2006, In : British journal of haematology. 133, 2, p. 158-164 7 p.

Research output: Contribution to journalArticle

98 Scopus citations

Prognostic value of chromosome 1q21 gain by fluorescent in situ hybridization and increase CKS1B expression in myeloma

Fonseca, R., Van Wier, S. A., Chng, W. J., Ketterling, R., Lacy, M. Q., Dispenzieri, A., Bergsagel, P. L., Rajkumar, S. V., Greipp, P. R., Litzow, M. R., Price-Troska, T., Henderson, K. J., Ahmann, G. J. & Gertz, M. A., Nov 2006, In : Leukemia. 20, 11, p. 2034-2040 7 p.

Research output: Contribution to journalArticle

147 Scopus citations
2007

6q deletion in Waldenström macroglobulinemia is associated with features of adverse prognosis

Ocio, E. M., Schop, R. F. J., Gonzalez, B., Van Wier, S. A., Hernandez-Rivas, J. M., Gutierrez, N. C., Garcia-Sanz, R., Moro, M. J., Aguilera, C., Hernandez, J., Xu, R., Greipp, P. R., Dispenzieri, A., Jalal, S. M., Lacy, M. Q., Gonzalez-Paz, N., Gertz, M. A., San Miguel, J. F. & Fonseca, R., Jan 1 2007, In : British journal of haematology. 136, 1, p. 80-86 7 p.

Research output: Contribution to journalArticle

78 Scopus citations

A practical guide to defining high-risk myeloma for clinical trials, patient counseling and choice of therapy

Stewart, A. K., Bergsagel, P. L., Greipp, P. R., Dispenzieri, A., Gertz, M. A., Hayman, S. R., Kumar, S., Lacy, M. Q., Lust, J. A., Russell, S. J., Witzig, T. E., Zeldenrust, S. R., Dingli, D., Reeder, C. B., Roy, V., Kyle, R. A., Rajkumar, S. V. & Fonseca, R., Mar 2007, In : Leukemia. 21, 3, p. 529-534 6 p.

Research output: Contribution to journalArticle

165 Scopus citations

Clinical course and prognosis of smoldering (asymptomatic) multiple myeloma

Kyle, R. A., Remstein, E. D., Therneau, T. M., Dispenzieri, A., Kurtin, P. J., Hodnefield, J. M., Larson, D. R., Plevak, M. F., Jelinek, D. F., Fonseca, R., Melton, L. J. & Rajkumar, S. V., Jun 21 2007, In : New England Journal of Medicine. 356, 25, p. 2582-2590 9 p.

Research output: Contribution to journalArticle

466 Scopus citations

Clinical significance of TP53 mutation in myeloma [13]

Chng, W. J., Price-Troska, T., Gonzalez-Paz, N., Van Wier, S., Jacobus, S., Blood, E., Henderson, K., Oken, M., Van Ness, B., Greipp, P., Rajkumar, S. V. & Fonseca, R., Mar 2007, In : Leukemia. 21, 3, p. 582-584 3 p.

Research output: Contribution to journalLetter

114 Scopus citations

Diagnostic evaluation of t(4;14) in multiple myeloma and evidence for clonal evolution [4]

Stewart, A. K., Chang, H., Trudel, S., Anderson, K. C., Richardson, P., Alsina, M., Reece, D., Young, S., Sable-Hunt, A., Li, Z., Keats, J., Van Wier, S., Ahmann, G., Price-Troska, T., Giusti, K., Bergsagel, P. L., Chesi, M. & Fonseca, R., Nov 2007, In : Leukemia. 21, 11, p. 2358-2359 2 p.

Research output: Contribution to journalLetter

18 Scopus citations

Expression and mutation status of candidate kinases in multiple myeloma [13]

Claudio, J. O., Zhan, F., Zhuang, L., Khaja, R., Zhu, Y. X., Sivananthan, K., Trudel, S., Masih-Khan, E., Fonseca, R., Bergsagel, P. L., Scherer, S. W., Shaughnessy, J. & Stewart, A. K., May 2007, In : Leukemia. 21, 5, p. 1124-1127 4 p.

Research output: Contribution to journalLetter

14 Scopus citations

Genomics and proteomics in multiple myeloma and Waldenström macroglobulinemia

Henry, T. & Fonseca, R., Jul 1 2007, In : Current opinion in hematology. 14, 4, p. 369-374 6 p.

Research output: Contribution to journalReview article

5 Scopus citations
246 Scopus citations

Long-term results of response to therapy, time to progression, and survival with lenalidomide plus dexamethasone in newly diagnosed myeloma

Lacy, M. Q., Gertz, M. A., Dispenzieri, A., Hayman, S. R., Geyer, S., Kabat, B., Zeldenrust, S. R., Kumar, S., Greipp, P. R., Fonseca, R., Lust, J. A., Russell, S. J., Kyle, R. A., Witzig, T. E., Bergsagel, P. L., Stewart, A. K. & Rajkumar, S. V., Oct 2007, In : Mayo Clinic proceedings. 82, 10, p. 1179-1184 6 p.

Research output: Contribution to journalArticle

138 Scopus citations

Molecular dissection of hyperdiploid multiple myeloma by gene expression profiling

Chng, W. J., Kumar, S., VanWier, S., Ahmann, G., Price-Troska, T., Henderson, K., Chung, T. H., Kim, S., Mulligan, G., Bryant, B., Carpten, J., Gertz, M., Rajkumar, S. V., Lacy, M., Dispenzieri, A., Kyle, R., Greipp, P., Bergsagel, P. L. & Fonseca, R., Apr 1 2007, In : Cancer research. 67, 7, p. 2982-2989 8 p.

Research output: Contribution to journalArticle

177 Scopus citations

Multiple myeloma and FISH (but no CHIPS)

Fonseca, R., Apr 15 2007, In : Blood. 109, 8, p. 3132-3133 2 p.

Research output: Contribution to journalComment/debate

1 Scopus citations

Prognostic Factors and Staging in Multiple Myeloma

Fonseca, R. & San Miguel, J., Dec 1 2007, In : Hematology/Oncology Clinics of North America. 21, 6, p. 1115-1140 26 p.

Research output: Contribution to journalReview article

33 Scopus citations

Promiscuous Mutations Activate the Noncanonical NF-κB Pathway in Multiple Myeloma

Keats, J. J., Fonseca, R., Chesi, M., Schop, R., Baker, A., Chng, W. J., Van Wier, S., Tiedemann, R., Shi, C. X., Sebag, M., Braggio, E., Henry, T., Zhu, Y. X., Fogle, H., Price-Troska, T., Ahmann, G., Mancini, C., Brents, L. A., Kumar, S., Greipp, P. & 10 others, Dispenzieri, A., Bryant, B., Mulligan, G., Bruhn, L., Barrett, M., Valdez, R., Trent, J., Stewart, A. K., Carpten, J. & Bergsagel, P. L., Aug 14 2007, In : Cancer cell. 12, 2, p. 131-144 14 p.

Research output: Contribution to journalArticle

739 Scopus citations

Proteomic analysis of Waldenstrom macroglobulinemia

Hatjiharissi, E., Ngo, H., Leontovich, A. A., Leleu, X., Timm, M., Melhem, M., George, D., Lu, G., Ghobrial, J., Alsayed, Y., Zeismer, S., Cabanela, M., Nehme, A., Jia, X., Moreau, A. S., Treon, S. P., Fonseca, R., Gertz, M. A., Anderson, K. C., Witzig, T. E. & 1 others, Ghobrial, I. M., Apr 15 2007, In : Cancer research. 67, 8, p. 3777-3784 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Review of molecular diagnostics in multiple myeloma

Stewart, A. K. & Fonseca, R., Jul 1 2007, In : Expert Review of Molecular Diagnostics. 7, 4, p. 453-459 7 p.

Research output: Contribution to journalReview article

19 Scopus citations
Open Access
10 Scopus citations

Targeted therapeutics for multiple myeloma: The arrival of a risk-stratified approach

Fonseca, R. & Stewart, A. K., Mar 1 2007, In : Molecular cancer therapeutics. 6, 3, p. 802-810 9 p.

Research output: Contribution to journalReview article

20 Scopus citations

Transfusion-Dependent Anemia After Initiation of Androgen Deprivation Therapy for Metastatic Prostate Cancer

Curtis, K. K., Pruthi, R. K., Fonseca, R. & Gornet, M. K., Oct 2007, In : Urology. 70, 4, p. 811.e5-811.e8

Research output: Contribution to journalArticle

4 Scopus citations

Treatment of newly diagnosed multiple myeloma based on Mayo stratification of myeloma and risk-adapted therapy (mSMART): Consensus statement

Dispenzieri, A., Rajkumar, S. V., Gertz, M. A., Fonseca, R., Lacy, M. Q., Bergsagel, P. L., Kyle, R. A., Greipp, P. R., Witzig, T. E., Reeder, C. B., Lust, J. A., Russell, S. J., Hayman, S. R., Roy, V., Kumar, S., Zeldenrust, S. R., Dalton, R. J. & Stewart, A. K., Mar 2007, In : Mayo Clinic proceedings. 82, 3, p. 323-341 19 p.

Research output: Contribution to journalArticle

156 Scopus citations