• 32065 Citations
  • 97 Scopus h-Index
19962020

Research output per year

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Research Output

2016

Outcome with lenalidomide plus dexamethasone followed by early autologous stem cell transplantation in patients with newly diagnosed multiple myeloma on the ECOG-ACRIN E4A03 randomized clinical trial: Long-term follow-up

Biran, N., Jacobus, S., Vesole, D. H., Callander, N. S., Fonseca, R., Williams, M. E., Abonour, R., Katz, M. S., Rajkumar, S. V., Greipp, P. R. & Siegel, D. S., Sep 2 2016, In : Blood Cancer Journal. 6, 9, e466.

Research output: Contribution to journalArticle

7 Scopus citations

Panel sequencing for clinically oriented variant screening and copy number detection in 142 untreated multiple myeloma patients

Kortuem, K. M., Braggio, E. D., Bruins, L., Barrio, S., Shi, C. S., Zhu, Y. X., Tibes, R., Viswanatha, D., Votruba, P., Ahmann, G., Fonseca, R., Jedlowski, P., Schlam, I., Kumar, S. K., Bergsagel, P. L. & Stewart, A. K., 2016, In : Blood Cancer Journal. 6, 2, e397.

Research output: Contribution to journalArticle

31 Scopus citations

Phase II trial of nab-paclitaxel in patients with relapsed or refractory multiple myeloma

Jain, T., Dueck, A., Kosiorek, H. E., Ginos, B. F., Mayo, A., Reeder, C. B., Chesi, M., Mikhael, J. R., Stewart, A. K., Bergsagel, P. L. & Fonseca, R., Dec 1 2016, In : American Journal of Hematology. 91, 12, p. E504-E505

Research output: Contribution to journalLetter

2 Scopus citations

PRIMA-1 targets the vulnerability of multiple myeloma of deregulated protein homeostasis through the perturbation of ER stress via p73 demethylation

Teoh, P. J., Bi, C., Sintosebastian, C., Tay, L. S., Fonseca, R. & Chng, W. J., Jan 1 2016, In : Oncotarget. 7, 38, p. 61806-61819 14 p.

Research output: Contribution to journalArticle

14 Scopus citations

Tumor-associated macrophages and extracellular matrix metalloproteinase inducer in prognosis of multiple myeloma

Panchabhai, S., Kelemen, K., Ahmann, G., Sebastian, S., Mantei, J. & Fonseca, R., Apr 1 2016, In : Leukemia. 30, 4, p. 951-954 4 p.

Research output: Contribution to journalLetter

19 Scopus citations
2015

Carfilzomib: A cause of drug associated thrombotic microangiopathy

Qaqish, I., Schlam, I. M., Chakkera, H. M., Fonseca, R. & Adamski, J., Aug 24 2015, (Accepted/In press) In : Transfusion and Apheresis Science.

Research output: Contribution to journalArticle

17 Scopus citations

Deep sequencing identifies genetic heterogeneity and recurrent convergent evolution in chronic lymphocytic leukemia

Ojha, J., Ayres, J., Secreto, C., Tschumper, R., Rabe, K., Van Dyke, D., Slager, S. L., Shanafelt, T., Fonseca, R., Kay, N. E. & Braggio, E. D., Jan 15 2015, In : Blood. 125, 3, p. 492-498 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Dinaciclib, a novel CDK inhibitor, demonstrates encouraging single-agent activity in patients with relapsed multiple myeloma

Mayo Phase Consortium, Jan 15 2015, In : Blood. 125, 3, p. 443-448 6 p.

Research output: Contribution to journalArticle

97 Scopus citations

Extramedullary Cardiac Multiple Myeloma-A Case Report and Contemporary Review of the Literature

Coakley, M., Yeneneh, B., Rosenthal, A., Fonseca, R. & Mookadam, F., Nov 29 2015, (Accepted/In press) In : Clinical Lymphoma, Myeloma and Leukemia.

Research output: Contribution to journalArticle

3 Scopus citations

Genome-wide analysis uncovers novel recurrent alterations in primary central nervous system lymphomas

Braggio, E., Van Wier, S., Ojha, J., McPhail, E., Asmann, Y. W., Egan, J., Da Silva, J. A., Schiff, D., Lopes, M. B., Decker, P. A., Valdez, R., Tibes, R., Eckloff, B., Witzig, T. E., Stewart, A. K., Fonseca, R. & O'Neill, B. P., Sep 1 2015, In : Clinical Cancer Research. 21, 17, p. 3986-3994 9 p.

Research output: Contribution to journalArticle

82 Scopus citations

Genome-wide pharmacologic unmasking identifies tumor suppressive microRNAs in multiple myeloma

Bi, C., Chung, T. H., Huang, G., Zhou, J., Yan, J., Ahmann, G. J., Fonseca, R. & Chng, W. J., Jan 1 2015, In : Oncotarget. 6, 28, p. 26508-26518 11 p.

Research output: Contribution to journalArticle

33 Scopus citations

Identification of recurrent truncated DDX3X mutations in chronic lymphocytic leukaemia

Ojha, J., Secreto, C. R., Rabe, K. G., Van Dyke, D. L., Kortum, K. M., Slager, S. L., Shanafelt, T. D., Fonseca, R., Kay, N. E. & Braggio, E. D., May 1 2015, In : British Journal of Haematology. 169, 3, p. 445-448 4 p.

Research output: Contribution to journalArticle

20 Scopus citations

Longitudinal analysis of 25 sequential sample-pairs using a custom multiple myeloma mutation sequencing panel (M<sup>3</sup>P)

Kortüm, K. M., Langer, C., Monge, J., Bruins, L., Zhu, Y. X., Shi, C. X., Jedlowski, P., Egan, J. B., Ojha, J., Bullinger, L., Kull, M., Ahmann, G., Rasche, L., Knop, S., Fonseca, R., Einsele, H., Stewart, A. K. & Braggio, E. D., Jul 18 2015, In : Annals of Hematology. 94, 7, p. 1205-1211 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Melphalan, prednisone, and thalidomide vs melphalan, prednisone, and lenalidomide (ECOG E1A06) in untreated multiple myeloma

Stewart, A. K., Jacobus, S., Fonseca, R., Weiss, M., Callander, N. S., Chanan Khan, A. A. & Rajkumar, S. V., Sep 10 2015, In : Blood. 126, 11, p. 1294-1301 8 p.

Research output: Contribution to journalArticle

50 Scopus citations

Phase 2 trial of ixazomib in patients with relapsed multiple myeloma not refractory to bortezomib

Kumar, S. K., Laplant, B., Roy, V., Reeder, C. B., Lacy, M., Gertz, M., Laumann, K., Thompson, M. A., Witzig, T. E., Buadi, F. K., Rivera, C. E., Mikhael, J. R., Bergsagel, P. L., Kapoor, P., Hwa, L., Fonseca, R., Stewart, A. K., Chanan Khan, A. A., Rajkumar, S. V. & Dispenzieri, A., Aug 14 2015, In : Blood Cancer Journal. 4, e338.

Research output: Contribution to journalArticle

50 Scopus citations

Targeted sequencing using a 47 gene multiple myeloma mutation panel (M3P) in -17p high risk disease

Kortüm, K. M., Langer, C., Monge, J., Bruins, L., Egan, J. B., Zhu, Y. X., Shi, C. X., Jedlowski, P., Schmidt, J., Ojha, J., Bullinger, L., Liebisch, P., Kull, M., Champion, M. D., Van Wier, S., Ahmann, G., Rasche, L., Knop, S., Fonseca, R., Einsele, H. & 2 others, Stewart, A. K. & Braggio, E., Feb 1 2015, In : British journal of haematology. 168, 4, p. 507-510 4 p.

Research output: Contribution to journalArticle

34 Scopus citations

Treatment of Immunoglobulin Light Chain Amyloidosis Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Statement

Dispenzieri, A., Buadi, F., Kumar, S. K., Reeder, C. B., Sher, T., Lacy, M., Kyle, R. A., Mikhael, J. R., Roy, V., Leung, N., Grogan, M., Kapoor, P., Lust, J. A., Dingli, D. M., Go, R. S., Hwa, Y. L., Hayman, S. R., Fonseca, R., Ailawadhi, S., Bergsagel, P. L. & 6 others, Chanan Khan, A. A., Rajkumar, S. V., Russell, S. J., Stewart, A. K., Zeldenrust, S. R. & Gertz, M., Aug 1 2015, In : Mayo Clinic Proceedings. 90, 8, p. 1054-1081 28 p.

Research output: Contribution to journalArticle

68 Scopus citations
2014

Absence of tissue factor is characteristic of lymphoid malignancies of both T- and B-cell origin

Cesarman-Maus, G., Braggio, E., Lome-Maldonado, C., Morales-Leyte, A. L. & Fonseca, R., Apr 2014, In : Thrombosis research. 133, 4, p. 606-609 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Activation of TAK1 by MYD88 L265P drives malignant B-cell growth in non-Hodgkin lymphoma

Ansell, S. M., Hodge, L. S., Secreto, F. J., Manske, M., Braggio, E., Price-Troska, T., Ziesmer, S., Li, Y., Johnson, S. H., Hart, S. N., Kocher, J. P. A., Vasmatzis, G., Chanan-Kahn, A., Gertz, M., Fonseca, R., Dogan, A., Cerhan, J. R. & Novak, A. J., Feb 2014, In : Blood cancer journal. 4, 2, 20144.

Research output: Contribution to journalArticle

50 Scopus citations

Activity of 129 single-agent drugs in 228 phase i and II clinical trials in multiple myeloma

Kortuem, K. M., Zidich, K., Schuster, S. R., Khan, M. L., Jimenez-Zepeda, V. H., Mikhael, J. R., Fonseca, R. & Stewart, A. K., Aug 2014, In : Clinical Lymphoma, Myeloma and Leukemia. 14, 4, p. 284-290.e5

Research output: Contribution to journalArticle

12 Scopus citations

Amitriptyline-induced agranulocytosis with bone marrow confirmation

Azadeh, N., Kelemen, K. & Fonseca, R., Oct 1 2014, In : Clinical Lymphoma, Myeloma and Leukemia. 14, 5, p. e183-e185

Research output: Contribution to journalArticle

Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma

Zhu, Y. X., Braggio, E., Shi, C. X., Kortuem, K. M., Bruins, L. A., Schmidt, J. E., Chang, X. B., Langlais, P., Luo, M., Jedlowski, P., LaPlant, B., Laumann, K., Fonseca, R., Bergsagel, P. L., Mikhael, J., Lacy, M., Champion, M. D. & Stewart, A. K., Jul 24 2014, In : Blood. 124, 4, p. 536-545 10 p.

Research output: Contribution to journalArticle

99 Scopus citations

Implementing individualized medicine into the medical practice

Lazaridis, K. N., MCAllister, T. M., Babovic-Vuksanovic, D., Beck, S. A., Borad, M. J., Bryce, A. H., Chanan-Khan, A. A., Ferber, M. J., Fonseca, R., Johnson, K. J., Klee, E. W., Lindor, N. M., McCormick, J. B., MCWilliams, R. R., Parker, A. S., Riegert-Johnson, D. L., Rohrer Vitek, C. R., Schahl, K. A., Schultz, C., Stewart, K. & 3 others, Then, G. C., Wieben, E. D. & Farrugia, G., Mar 2014, In : American Journal of Medical Genetics, Part C: Seminars in Medical Genetics. 166, 1, p. 15-23 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

IMWG consensus on risk stratification in multiple myeloma

Chng, W. J., Dispenzieri, A., Chim, C. S., Fonseca, R., Goldschmidt, H., Lentzsch, S., Munshi, N., Palumbo, A., Miguel, J. S., Sonneveld, P., Cavo, M., Usmani, S., Durie, B. G. & Avet-Loiseau, H., Feb 1 2014, In : Leukemia. 28, 2, p. 269-277 9 p.

Research output: Contribution to journalReview article

296 Scopus citations

Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic Cholangiocarcinoma

Borad, M. J., Champion, M. D., Egan, J. B., Liang, W. S., Fonseca, R., Bryce, A. H., McCullough, A. E., Barrett, M. T., Hunt, K., Patel, M. D., Young, S. W., Collins, J. M., Silva, A. C., Condjella, R. M., Block, M., McWilliams, R. R., Lazaridis, K. N., Klee, E. W., Bible, K. C., Harris, P. & 29 others, Oliver, G. R., Bhavsar, J. D., Nair, A. A., Middha, S., Asmann, Y., Kocher, J. P., Schahl, K., Kipp, B. R., Barr Fritcher, E. G., Baker, A., Aldrich, J., Kurdoglu, A., Izatt, T., Christoforides, A., Cherni, I., Nasser, S., Reiman, R., Phillips, L., McDonald, J., Adkins, J., Mastrian, S. D., Placek, P., Watanabe, A. T., LoBello, J., Han, H., Von Hoff, D., Craig, D. W., Stewart, A. K. & Carpten, J. D., Feb 1 2014, In : PLoS genetics. 10, 2, e1004135.

Research output: Contribution to journalArticle

169 Scopus citations

Leukocyte cell-derived chemotaxin 2 (LECT2)-associated amyloidosis is a frequent cause of hepatic amyloidosis in the United States

Mereuta, O. M., Theis, J. D., Vrana, J. A., Law, M. E., Grogg, K. L., Dasari, S., Chandan, V. S., Wu, T. T., Jimenez-Zepeda, V. H., Fonseca, R., Dispenzieri, A., Kurtin, P. J. & Dogan, A. M., Mar 6 2014, In : Blood. 123, 10, p. 1479-1482 4 p.

Research output: Contribution to journalArticle

41 Scopus citations

Long-term survival with cyclophosphamide, bortezomib and dexamethasone induction therapy in patients with newly diagnosed multiple myeloma

Reeder, C. B., Reece, D. E., Kukreti, V., Mikhael, J. R., Chen, C., Trudel, S., Laumann, K., Vohra, H., Fonseca, R., Bergsagel, P. L., Leis, J. F., Tiedemann, R. & Stewart, A. K., Nov 1 2014, In : British journal of haematology. 167, 4, p. 563-565 3 p.

Research output: Contribution to journalLetter

31 Scopus citations

Molecular classification and risk stratifiCation

Kumar, S. K., Fonseca, R. & Stewart, A. K., Jan 1 2014, Multiple Myeloma: Diagnosis and Treatment. Springer New York, p. 55-64 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Monoclonal B-cell lymphocytosis is characterized by mutations in CLL putative driver genes and clonal heterogeneity many years before disease progression

Ojha, J., Secreto, C., Rabe, K., Ayres-Silva, J., Tschumper, R., Dyke, D. V., Slager, S. L., Fonseca, R., Shanafelt, T., Kay, N. E. & Braggio, E. D., Jul 18 2014, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

31 Scopus citations

P53 haploinsufficiency and functional abnormalities in multiple myeloma

Teoh, P. J., Chung, T. H., Sebastian, S., Choo, S. N., Yan, J., Ng, S. B., Fonseca, R. & Chng, W. J., Oct 1 2014, In : Leukemia. 28, 10, p. 2066-2074 9 p.

Research output: Contribution to journalArticle

45 Scopus citations

Predicting multiple myeloma disease activity by analyzing natural calcium isotopic composition

Gordon, G. W., Monge, J., Channon, M. B., Wu, Q., Skulan, J. L., Anbar, A. D. & Fonseca, R., Oct 1 2014, In : Leukemia. 28, 10, p. 2112-2115 4 p.

Research output: Contribution to journalLetter

19 Scopus citations

Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma

Affer, M., Chesi, M., Chen, W. D., Keats, J. J., Demchenko, Y. N., Tamizhmani, K., Garbitt, V. M., Riggs, D. L., Brents, L. A., Roschke, A. V., Van Wier, S., Fonseca, R., Bergsagel, P. L. & Kuehl, W. M., Aug 2014, In : Leukemia. 28, 8, p. 1725-1735 11 p.

Research output: Contribution to journalArticle

127 Scopus citations

Staging and prognostication of multiple myeloma

Fonseca, R., Monge, J. & Dimopoulos, M. A., Feb 1 2014, In : Expert Review of Hematology. 7, 1, p. 21-31 11 p.

Research output: Contribution to journalReview article

22 Scopus citations

The clinical significance of cereblon expression in multiple myeloma

Schuster, S. R., Kortuem, K. M., Zhu, Y. X., Braggio, E., Shi, C. X., Bruins, L. A., Schmidt, J. E., Ahmann, G., Kumar, S., Rajkumar, S. V., Mikhael, J., LaPlant, B., Champion, M. D., Laumann, K., Barlogie, B., Fonseca, R., Bergsagel, P. L., Lacy, M. & Stewart, A. K., Jan 1 2014, In : Leukemia Research. 38, 1, p. 23-28 6 p.

Research output: Contribution to journalArticle

57 Scopus citations

Trisomies in multiple myeloma: Impact on survival in patients with high-risk cytogenetics. (Blood (2012) 119, 9 (2100-2105))

Kumar, S., Fonseca, R. & Ketterling, R. P., Mar 6 2014, In : Blood. 123, 10, 1 p.

Research output: Contribution to journalComment/debate

Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 rearrangements

Egan, J. B., Barrett, M. T., Champion, M. D., Middha, S., Lenkiewicz, E., Evers, L., Francis, P., Schmidt, J., Shi, C. X., Van Wier, S., Badar, S., Ahmann, G., Kortuem, K. M., Boczek, N. J., Fonseca, R., Craig, D. W., Carpten, J. D., Borad, M. J. & Stewart, A. K., Feb 5 2014, In : PloS one. 9, 2, e87113.

Research output: Contribution to journalArticle

10 Scopus citations
2013

A Novel Measure of Chromosome Instability Can Account for Prognostic Difference in Multiple Myeloma

Chung, T. H., Mulligan, G., Fonseca, R. & Chng, W. J., Jun 20 2013, In : PloS one. 8, 6, e66361.

Research output: Contribution to journalArticle

26 Scopus citations

CGH protocols: Chronic lymphocytic leukemia

Braggio, E., Fonseca, R. & Kay, N. E., 2013, Array Comparative Genomic Hybridization: Protocols and Applications. Humana Press Inc., p. 87-98 12 p. (Methods in Molecular Biology; vol. 973).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Combining fluorescent in situ hybridization data with ISS staging improves risk assessment in myeloma: An International Myeloma Working Group collaborative project

Avet-Loiseau, H., Durie, B. G. M., Cavo, M., Attal, M., Gutierrez, N., Haessler, J., Goldschmidt, H., Hajek, R., Lee, J. H., Sezer, O., Barlogie, B., Crowley, J., Fonseca, R., Testoni, N., Ross, F., Rajkumar, S. V., Sonneveld, P., Lahuerta, J., Moreau, P. & Morgan, G., Mar 1 2013, In : Leukemia. 27, 3, p. 711-717 7 p.

Research output: Contribution to journalArticle

131 Scopus citations

Cytogenetic abnormalities in MGUS and myeloma

Fonseca, R., Bergsagel, P. L. & Kuehl, W. M., Nov 1 2013, Neoplastic Diseases of the Blood. Springer New York, p. 589-599 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Dissecting karyotypic patterns in non-hyperdiploid multiple myeloma: An overview on the karyotypic evolution

Jimenez-Zepeda, V. H., Braggio, E. & Fonseca, R., Oct 1 2013, In : Clinical Lymphoma, Myeloma and Leukemia. 13, 5, p. 552-558 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Downregulation of specific miRNAs in hyperdiploid multiple myeloma mimics the oncogenic effect of IgH translocations occurring in the non-hyperdiploid subtype

Rio-Machin, A., Ferreira, B. I., Henry, T., Gómez-López, G., Agirre, X., Alvarez, S., Rodriguez-Perales, S., Prosper, F., Calasanz, M. J., Martínez, J., Fonseca, R. & Cigudosa, J. C., Apr 1 2013, In : Leukemia. 27, 4, p. 925-931 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Genetics of multiple myeloma

Schuster, S., Braggio, E. D. & Fonseca, R., May 1 2013, Genetic and Molecular Epidemiology of Multiple Myeloma. Springer New York, Vol. 9781461446606. p. 1-16 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Genomic strategies determining progression from MGUS to multiple myeloma

Braggio, E. D. & Fonseca, R., Jan 1 2013, Advances in Biology and Therapy of Multiple Myeloma: Volume 1: Basic Science. Springer New York, p. 3-24 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hypodiploid multiple myeloma is characterized by more aggressive molecular markers than non-hyperdiploid multiple myeloma

Van Wier, S., Braggio, E., Baker, A., Ahmann, G., Levy, J., Carpten, J. D. & Fonseca, R., Oct 1 2013, In : Haematologica. 98, 10, p. 1586-1592 7 p.

Research output: Contribution to journalArticle

35 Scopus citations

Impact of primary molecular cytogenetic abnormalities and risk of progression in smoldering multiple myeloma

Rajkumar, S. V., Gupta, V., Fonseca, R., Dispenzieri, A., Gonsalves, W. I., Larson, D., Ketterling, R. P., Lust, J. A., Kyle, R. A. & Kumar, S. K., Aug 1 2013, In : Leukemia. 27, 8, p. 1738-1744 7 p.

Research output: Contribution to journalArticle

110 Scopus citations