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Purna C Kashyap, MBBS

  • 2968 Citations
  • 26 Scopus h-Index
20042019

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2019

A decreased abundance of clostridia characterizes the gut microbiota in eosinophilic esophagitis

Kashyap, P. C., Johnson, S., Geno, D. M., Lekatz, H. R., Lavey, C., Alexander, J. A., Chen, J. & Katzka, D. A., Oct 1 2019, In : Physiological reports. 7, 20, e14261.

Research output: Contribution to journal › Article

Open Access

An Increased Abundance of Clostridiaceae Characterizes Arthritis in Inflammatory Bowel Disease and Rheumatoid Arthritis: A Cross-sectional Study

Muñiz Pedrogo, D. A., Chen, J., Hillmann, B., Jeraldo, P., Al-Ghalith, G., Taneja, V., Davis, J. M., Knights, D., Nelson, H., Faubion, W. A., Raffals, L. & Kashyap, P. C., Apr 11 2019, In : Inflammatory bowel diseases. 25, 5, p. 902-913 12 p.

Research output: Contribution to journal › Article

4 Scopus citations

Assessment of a Personalized Approach to Predicting Postprandial Glycemic Responses to Food Among Individuals Without Diabetes

Mendes-Soares, H., Raveh-Sadka, T., Azulay, S., Edens, K., Ben-Shlomo, Y., Cohen, Y., Ofek, T., Bachrach, D., Stevens, J., Colibaseanu, D., Segal, L., Kashyap, P. C. & Nelson, H., Feb 1 2019, In : JAMA network open. 2, 2, p. e188102

Research output: Contribution to journal › Article

Open Access
17 Scopus citations

Model of personalized postprandial glycemic response to food developed for an Israeli cohort predicts responses in Midwestern American individuals

Mendes-Soares, H., Raveh-Sadka, T., Azulay, S., Ben-Shlomo, Y., Cohen, Y., Ofek, T., Stevens, J., Bachrach, D., Kashyap, P. C., Segal, L. & Nelson, H., Jul 1 2019, In : American Journal of Clinical Nutrition. 110, 1, p. 63-75 13 p., nzq028.

Research output: Contribution to journal › Article

Open Access
5 Scopus citations

Serine proteases as luminal mediators of intestinal barrier dysfunction and symptom severity in IBS

Edogawa, S., Edwinson, A. L., Peters, S. A., Chikkamenahalli, L. L., Sundt, W., Graves, S., Gurunathan, S. V., Breen-Lyles, M., Johnson, S., Dyer, R., Graham, R., Chen, J., Kashyap, P., Farrugia, G. & Grover, M., Jan 1 2019, In : Gut.

Research output: Contribution to journal › Article

1 Scopus citations

Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders

Saffouri, G. B., Shields-Cutler, R. R., Chen, J., Yang, Y., Lekatz, H. R., Hale, V. L., Cho, J. M., Battaglioli, E. J., Bhattarai, Y., Thompson, K. J., Kalari, K. K., Behera, G., Berry, J. C., Peters, S. A., Patel, R., Schuetz, A. N., Faith, J. J., Camilleri, M., Sonnenburg, J. L., Farrugia, G. & 4 others, Swann, J. R., Grover, M., Knights, D. & Kashyap, P. C., Dec 1 2019, In : Nature communications. 10, 1, 2012.

Research output: Contribution to journal › Article

Open Access
10 Scopus citations

The ‘in vivo lifestyle’ of bile acid 7α-dehydroxylating bacteria: comparative genomics, metatranscriptomic, and bile acid metabolomics analysis of a defined microbial community in gnotobiotic mice

Ridlon, J. M., Devendran, S., Alves, J. M., Doden, H., Wolf, P. G., Pereira, G. V., Ly, L., Volland, A., Takei, H., Nittono, H., Murai, T., Kurosawa, T., Chlipala, G. E., Green, S. J., Hernandez, A. G., Fields, C. J., Wright, C. L., Kakiyama, G., Cann, I., Kashyap, P. C. & 2 others, McCracken, V. & Gaskins, H. R., Jan 1 2019, In : Gut Microbes.

Research output: Contribution to journal › Article

3 Scopus citations
2018

Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea

Battaglioli, E. J., Hale, V. L., Chen, J., Jeraldo, P., Ruiz-Mojica, C., Schmidt, B. A., Rekdal, V. M., Till, L. M., Huq, L., Smits, S. A., Moor, W. J., Jones-Hall, Y., Smyrk, T. C., Khanna, S., Pardi, D. S., Grover, M., Patel, R., Chia, N. D., Nelson, H., Sonnenburg, J. L. & 2 others, Farrugia, G. & Kashyap, P. C., Oct 24 2018, In : Science Translational Medicine. 10, 464, eaam7019.

Research output: Contribution to journal › Article

14 Scopus citations

Enterococcus faecalis sex pheromone cCF10 enhances conjugative plasmid transfer in vivo

Hirt, H., Greenwood-Quaintance, K. E., Karau, M. J., Till, L. M., Kashyap, P. C., Patel, R. & Dunny, G. M., Jan 1 2018, In : mBio. 9, 1, e00037-18.

Research output: Contribution to journal › Article

13 Scopus citations

Gut Microbial Carbohydrate Metabolism Hinders Weight Loss in Overweight Adults Undergoing Lifestyle Intervention With a Volumetric Diet

Muñiz Pedrogo, D. A., Jensen, M. D., Van Dyke, C. T., Murray, J. A., Woods, J. A., Chen, J., Kashyap, P. C. & Nehra, V., Aug 1 2018, In : Mayo Clinic Proceedings. 93, 8, p. 1104-1110 7 p.

Research output: Contribution to journal › Article

10 Scopus citations

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

Bhattarai, Y., Williams, B. B., Battaglioli, E. J., Whitaker, W. R., Till, L., Grover, M., Linden, D. R., Akiba, Y., Kandimalla, K. K., Zachos, N. C., Kaunitz, J. D., Sonnenburg, J. L., Fischbach, M. A., Farrugia, G. & Kashyap, P. C., Jun 13 2018, In : Cell Host and Microbe. 23, 6, p. 775-785.e5

Research output: Contribution to journal › Article

33 Scopus citations

Increased Prevalence of Rare Sucrase-isomaltase (SI) Pathogenic Variants in Irritable Bowel Syndrome Patients

Garcia-Etxebarria, K., Zheng, T., Bonfiglio, F., Bujanda, L., Dlugosz, A., Lindberg, G., Schmidt, P. T., Karling, P., Ohlsson, B., Simren, M., Walter, S., Nardone, G., Cuomo, R., Usai-Satta, P., Galeazzi, F., Neri, M., Portincasa, P., Bellini, M., Barbara, G., Jonkers, D. & 10 others, Eswaran, S., Chey, W. D., Kashyap, P. C., Chang, L., Mayer, E. A., Wouters, M. M., Boeckxstaens, G., Camilleri, M., Franke, A. & D'Amato, M., Jan 1 2018, (Accepted/In press) In : Clinical Gastroenterology and Hepatology.

Research output: Contribution to journal › Article

9 Scopus citations

Sex differences in NSAID-induced perturbation of human intestinal barrier function and microbiota

Edogawa, S., Peters, S. A., Jenkins, G. D., Gurunathan, S. V., Sundt, W. J., Johnson, S., Lennon, R. J., Dyer, R. B., Camilleri, M., Kashyap, P. C., Farrugia, G., Chen, J., Singh, R. J. & Grover, M., Dec 1 2018, In : FASEB Journal. 32, 12, p. 6615-6625 11 p.

Research output: Contribution to journal › Article

8 Scopus citations

US Immigration Westernizes the Human Gut Microbiome

Vangay, P., Johnson, A. J., Ward, T. L., Al-Ghalith, G. A., Shields-Cutler, R. R., Hillmann, B. M., Lucas, S. K., Beura, L. K., Thompson, E. A., Till, L. M., Batres, R., Paw, B., Pergament, S. L., Saenyakul, P., Xiong, M., Kim, A. D., Kim, G., Masopust, D., Martens, E. C., Angkurawaranon, C. & 4 others, McGready, R., Kashyap, P. C., Culhane-Pera, K. A. & Knights, D., Nov 1 2018, In : Cell. 175, 4, p. 962-972.e10

Research output: Contribution to journal › Article

73 Scopus citations
2017

Beware! Are bacteria raising your oxidative stress?

Kashyap, P. C., Feb 22 2017, In : Science Translational Medicine. 9, 378

Research output: Contribution to journal › Article

Changes in microbial ecology after fecal microbiota transplantation for recurrent C. difficile infection affected by underlying inflammatory bowel disease

Khanna, S., Vazquez-Baeza, Y., González, A., Weiss, S., Schmidt, B., Muñiz-Pedrogo, D. A., Rainey, J. F., Kammer, P., Nelson, H., Sadowsky, M., Khoruts, A., Farrugia, S. L., Knight, R., Pardi, D. S. & Kashyap, P. C., May 15 2017, In : Microbiome. 5, 1, p. 55 1 p.

Research output: Contribution to journal › Article

34 Scopus citations

Enterococcus faecalis readily colonizes the entire gastrointestinal tract and forms biofilms in a germ-free mouse model

Barnes, A. M. T., Dale, J. L., Chen, Y., Manias, D. A., Greenwood Quaintance, K. E., Karau, M. K., Kashyap, P. C., Patel, R., Wells, C. L. & Dunny, G. M., Feb 6 2017, (Accepted/In press) In : Virulence. p. 1-15 15 p.

Research output: Contribution to journal › Article

13 Scopus citations

Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice

Allen, J. M., Mailing, L. J., Cohrs, J., Salmonson, C., Fryer, J. D., Nehra, V., Hale, V. L., Kashyap, P. C., White, B. A. & Woods, J. A., Sep 19 2017, (Accepted/In press) In : Gut Microbes. p. 1-16 16 p.

Research output: Contribution to journal › Article

26 Scopus citations

Human-derived gut microbiota modulates colonic secretion in mice by regulating 5-HT3 receptor expression via acetate production

Bhattarai, Y., Schmidt, B. A., Linden, D. R., Larson, E. D., Grover, M., Beyder, A., Farrugia, G. & Kashyap, P. C., 2017, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 313, 1, p. G80-G87

Research output: Contribution to journal › Article

23 Scopus citations

Metabolites and microbial composition of stool of women with fecal incontinence: Study design and methods

Arya, L. A., Richter, H. E., Jelovsek, E., Gantz, M., Cichowski, S., Zyczynski, H., Dyer, K., Siddiqui, N., Carberry, C., Broeckling, C., Morrow, C., Kashyap, P. C. & Meikle, S., 2017, (Accepted/In press) In : Neurourology and Urodynamics.

Research output: Contribution to journal › Article

Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models

Touw, K., Ringus, D. L., Hubert, N., Wang, Y., Leone, V. A., Nadimpalli, A., Theriault, B. R., Huang, Y. E., Tune, J. D., Herring, P. B., Farrugia, G., Kashyap, P. C., Antonopoulos, D. A. & Chang, E. B., Mar 1 2017, In : Physiological Reports. 5, 6, e13182.

Research output: Contribution to journal › Article

10 Scopus citations

Screening for Clostridium difficile colonization on admission to a hematopoietic stem cell transplant unit may reduce hospital-acquired C difficile infection

Cho, J., Seville, M. T., Khanna, S., Pardi, D. S., Sampathkumar, P. & Kashyap, P. C., Jan 1 2017, (Accepted/In press) In : American Journal of Infection Control.

Research output: Contribution to journal › Article

4 Scopus citations
2016

Altered gut microbiota in female mice with persistent low body weights following removal of post-weaning chronic dietary restriction

Chen, J., Toyomasu, Y., Hayashi, Y., Linden, D. R., Szurszewski, J. H., Nelson, H., Farrugia, G., Kashyap, P. C., Chia, N. D. & Ordog, T., Oct 3 2016, In : Genome Medicine. 8, 1, 103.

Research output: Contribution to journal › Article

9 Scopus citations

Correlated gene expression encoding serotonin (5-HT) receptor 4 and 5-HT transporter in proximal colonic segments of mice across different colonization states and sexes

Reigstad, C. S., Linden, D. R., Szurszewski, J. H., Sonnenburg, J. L., Farrugia, G. & Kashyap, P. C., Sep 1 2016, In : Neurogastroenterology and Motility. 28, 9, p. 1443-1448 6 p.

Research output: Contribution to journal › Article

3 Scopus citations

Germ-free mice model for studying host–microbial interactions

Bhattarai, Y. & Kashyap, P. C., May 1 2016, In : Methods in Molecular Biology. 1438, p. 123-135 13 p.

Research output: Contribution to journal › Article

14 Scopus citations

Gut microbiome predictors of treatment response and recurrence in primary Clostridium difficile infection

Khanna, S., Montassier, E., Schmidt, B., Patel, R., Knights, D., Pardi, D. S. & Kashyap, P. C., 2016, (Accepted/In press) In : Alimentary Pharmacology and Therapeutics.

Research output: Contribution to journal › Article

30 Scopus citations

High risk of post-infectious irritable bowel syndrome in patients with Clostridium difficile infection

Wadhwa, A., Al Nahhas, M. F., Dierkhising, R. A., Patel, R., Kashyap, P. C., Pardi, D. S., Khanna, S. & Grover, M., Sep 1 2016, In : Alimentary Pharmacology and Therapeutics. 44, 6, p. 576-582 7 p.

Research output: Contribution to journal › Article

35 Scopus citations

Individualized responses of gut microbiota to dietary intervention modeled in humanized mice

Smits, S. A., Marcobal, A., Higginbottom, S., Sonnenburg, J. L. & Kashyap, P. C., Sep 1 2016, In : mSystems. 1, 5, e00098.

Research output: Contribution to journal › Article

18 Scopus citations

Innovative gastric endoscopic muscle biopsy to identify all cell types, including myenteric neurons and interstitial cells of Cajal in patients with idiopathic gastroparesis: A feasibility study (with video)

Rajan, E., Gostout, C. J., Wong Kee Song, L. M., Szarka, L., Kashyap, P. C., Smyrk, T. C., Bingener, J., Deters, J. L., Knipschield, M. A., Bernard, C. E. & Farrugia, G., Feb 22 2016, (Accepted/In press) In : Gastrointestinal Endoscopy.

Research output: Contribution to journal › Article

13 Scopus citations

Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice

Choi, K. M., Gibbons, S. J., Sha, L., Beyder, A., Verhulst, P. J., Cipriani, G., Phillips, J. E., Bauer, A. J., Ordog, T., Camp, J. J., Ge, X., Bharucha, A. E., Linden, D. R., Szurszewski, J. H., Kashyap, P. C. & Farrugia, G., Jul 1 2016, In : CMGH Cellular and Molecular Gastroenterology and Hepatology. 2, 4, p. 454-467 14 p.

Research output: Contribution to journal › Article

12 Scopus citations

Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces

Wang, F., Knutson, K., Alcaino, C., Linden, D. R., Gibbons, S. J., Kashyap, P. C., Grover, M., Oeckler, R., Gottlieb, P. A., Li, H. J., Leiter, A. B., Farrugia, G. & Beyder, A., 2016, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journal › Article

44 Scopus citations
2015

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

Reigstad, C. S., Salmonson, C. E., Rainey, J. F., Szurszewski, J. H., Linden, D. R., Sonnenburg, J. L., Farrugia, G. & Kashyap, P. C., Apr 1 2015, In : FASEB Journal. 29, 4, p. 1395-1403 9 p.

Research output: Contribution to journal › Article

246 Scopus citations
2014

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

Williams, B. B., Van Benschoten, A. H., Cimermancic, P., Donia, M. S., Zimmermann, M., Taketani, M., Ishihara, A., Kashyap, P. C., Fraser, J. S. & Fischbach, M. A., Oct 8 2014, In : Cell Host and Microbe. 16, 4, p. 495-503 9 p.

Research output: Contribution to journal › Article

131 Scopus citations

Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism

Tong, M., McHardy, I., Ruegger, P., Goudarzi, M., Kashyap, P. C., Haritunians, T., Li, X., Graeber, T. G., Schwager, E., Huttenhower, C., Fornace, A. J., Sonnenburg, J. L., McGovern, D. P. B., Borneman, J. & Braun, J., Nov 25 2014, In : ISME Journal. 8, 11, p. 2193-2206 14 p.

Research output: Contribution to journal › Article

102 Scopus citations
2013

A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice

Marcobal, A., Kashyap, P. C., Nelson, T. A., Aronov, P. A., Donia, M. S., Spormann, A., Fischbach, M. A. & Sonnenburg, J. L., Oct 1 2013, In : ISME Journal. 7, 10, p. 1933-1943 11 p.

Research output: Contribution to journal › Article

153 Scopus citations

Complex interactions among diet, gastrointestinal transit, and gut microbiota in humanized mice

Kashyap, P. C., Marcobal, A., Ursell, L. K., Larauche, M., Duboc, H., Earle, K. A., Sonnenburg, E. D., Ferreyra, J. A., Higginbottom, S. K., Million, M., Tache, Y., Pasricha, P. J., Knight, R., Farrugia, G. & Sonnenburg, J. L., May 2013, In : Gastroenterology. 144, 5, p. 967-977 11 p.

Research output: Contribution to journal › Article

190 Scopus citations

Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota

Kashyap, P. C., Marcobal, A., Ursell, L. K., Smits, S. A., Sonnenburg, E. D., Costello, E. K., Higginbottom, S. K., Domino, S. E., Holmes, S. P., Relman, D. A., Knight, R., Gordon, J. I. & Sonnenburg, J. L., Oct 15 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 42, p. 17059-17064 6 p.

Research output: Contribution to journal › Article

131 Scopus citations

Microbiota-liberated host sugars facilitate post-antibiotic expansion of enteric pathogens

Ng, K. M., Ferreyra, J. A., Higginbottom, S. K., Lynch, J. B., Kashyap, P. C., Gopinath, S., Naidu, N., Choudhury, B., Weimer, B. C., Monack, D. M. & Sonnenburg, J. L., Sep 3 2013, In : Nature. 502, 7469, p. 96-99 4 p.

Research output: Contribution to journal › Article

441 Scopus citations

Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota

Wieland Brown, L. C., Penaranda, C., Kashyap, P. C., Williams, B. B., Clardy, J., Kronenberg, M., Sonnenburg, J. L., Comstock, L. E., Bluestone, J. A. & Fischbach, M. A., Jul 1 2013, In : PLoS biology. 11, 7, e1001610.

Research output: Contribution to journal › Article

123 Scopus citations
2011

Immunoreactivity for Ano1 detects depletion of Kit-positive interstitial cells of Cajal in patients with slow transit constipation

Kashyap, P., Gomez-Pinilla, P. J., Pozo, M. J., Cima, R. R., Dozois, E. J., Larson, D. W., Ordog, T., Gibbons, S. J. & Farrugia, G., Aug 1 2011, In : Neurogastroenterology and Motility. 23, 8, p. 760-765 6 p.

Research output: Contribution to journal › Article

33 Scopus citations

Percutaneous endoscopic gastrostomy tract salvage using natural orifice transluminal endoscopic surgery technique (with video)

Sweetser, S., Kashyap, P. & Baron, T. H., Apr 1 2011, In : Gastrointestinal endoscopy. 73, 4, p. 839-840 2 p.

Research output: Contribution to journal › Article

1 Scopus citations
2010

Carbon monoxide reverses diabetic gastroparesis in NOD mice

Kashyap, P. C., Choi, K. M., Dutta, N., Linden, D. R., Szurszewski, J. H., Gibbons, S. J. & Farrugia, G., Jun 1 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 298, 6, p. G1013-G1019

Research output: Contribution to journal › Article

45 Scopus citations

CD206-Positive M2 Macrophages That Express Heme Oxygenase-1 Protect Against Diabetic Gastroparesis in Mice

Choi, K. M., Kashyap, P. C., Dutta, N., Stoltz, G. J., Ordog, T., Shea Donohue, T., Bauer, A. J., Linden, D. R., Szurszewski, J. H., Gibbons, S. J. & Farrugia, G., Jun 2010, In : Gastroenterology. 138, 7, p. 2399-2409.e1

Research output: Contribution to journal › Article

124 Scopus citations

HMGA1 and HMGA2 rearrangements in mass-forming endometriosis

Medeiros, F., Araujo, A. R., Erickson-Johnson, M. R., Kashyap, P. C., Dal Cin, P., Nucci, M., Wang, X., Bell, D. A. & Oliveira, A. M., Jul 1 2010, In : Genes Chromosomes and Cancer. 49, 7, p. 630-634 5 p.

Research output: Contribution to journal › Article

15 Scopus citations

Nephrogenic systemic fibrosis following acute kidney injury and exposure to gadolinium

Bhaskaran, A., Kashyap, P., Kelly, B. & Ghera, P., Jan 1 2010, In : Indian Journal of Medical Sciences. 64, 1, p. 33-36 4 p.

Research output: Contribution to journal › Article

2009

The D2/D3 agonist PD128907 (R-(+)-trans-3,4a,10b-tetrahydro-4-Propyl-2H,5H- [1]benzopyrano[4,3-b]-1,4-oxazin-9-ol) inhibits stimulated pyloric relaxation and spontaneous gastric emptying

Kashyap, P., Micci, M. A., Pasricha, S. & Pasricha, P. J., Jan 1 2009, In : Digestive diseases and sciences. 54, 1, p. 57-62 6 p.

Research output: Contribution to journal › Article

8 Scopus citations
2008

Body mass index and per capita income influence duodenal ulcer healing and H. pylori eradication whilst dietary factors play no part.

Singh, N., Deb, R., Kashyap, P. C., Bhatia, V., Ahuja, V. & Sharma, M. P., Jan 1 2008, In : Tropical gastroenterology : official journal of the Digestive Diseases Foundation. 29, 1, p. 26-31 6 p.

Research output: Contribution to journal › Article

6 Scopus citations
2004

Comparison of efficacy of pantoprazole alone versus pantoprazole plus mosapride in therapy of gastroesophageal reflux disease: A randomized trial

Madan, K., Ahuja, V., Kashyap, P. C. & Sharma, M. P., Dec 1 2004, In : Diseases of the Esophagus. 17, 4, p. 274-278 5 p.

Research output: Contribution to journal › Article

48 Scopus citations