• 2789 Citations
  • 25 Scopus h-Index
20042019
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Research Output 2004 2019

2019

A decreased abundance of clostridia characterizes the gut microbiota in eosinophilic esophagitis

Kashyap, P. C., Johnson, S., Geno, D. M., Lekatz, H. R., Lavey, C., Alexander, J. A., Chen, J. & Katzka, D. A., Oct 1 2019, In : Physiological reports. 7, 20, e14261.

Research output: Contribution to journalArticle

Open Access
Eosinophilic Esophagitis
Clostridium
Asthma
Bacteroidetes
Budesonide
4 Citations (Scopus)

An Increased Abundance of Clostridiaceae Characterizes Arthritis in Inflammatory Bowel Disease and Rheumatoid Arthritis: A Cross-sectional Study

Muñiz Pedrogo, D. A., Chen, J., Hillmann, B., Jeraldo, P., Al-Ghalith, G., Taneja, V., Davis, J. M., Knights, D., Nelson, H., Faubion, W. A., Raffals, L. & Kashyap, P. C., Apr 11 2019, In : Inflammatory bowel diseases. 25, 5, p. 902-913 12 p.

Research output: Contribution to journalArticle

Inflammatory Bowel Diseases
Arthritis
Rheumatoid Arthritis
Cross-Sectional Studies
Joint Diseases
13 Citations (Scopus)

Assessment of a Personalized Approach to Predicting Postprandial Glycemic Responses to Food Among Individuals Without Diabetes

Mendes-Soares, H., Raveh-Sadka, T., Azulay, S., Edens, K., Ben-Shlomo, Y., Cohen, Y., Ofek, T., Bachrach, D., Stevens, J., Colibaseanu, D., Segal, L., Kashyap, P. C. & Nelson, H., Feb 1 2019, In : JAMA network open. 2, 2, p. e188102

Research output: Contribution to journalArticle

Open Access
Food
Microbiota
Blood Glucose
Carbohydrates
Standard of Care
2 Citations (Scopus)

Model of personalized postprandial glycemic response to food developed for an Israeli cohort predicts responses in Midwestern American individuals

Mendes-Soares, H., Raveh-Sadka, T., Azulay, S., Ben-Shlomo, Y., Cohen, Y., Ofek, T., Stevens, J., Bachrach, D., Kashyap, P. C., Segal, L. & Nelson, H., Jul 1 2019, In : American Journal of Clinical Nutrition. 110, 1, p. 63-75 13 p., nzq028.

Research output: Contribution to journalArticle

Open Access
Meals
Food
Microbiota
Aptitude
Age Distribution

Serine proteases as luminal mediators of intestinal barrier dysfunction and symptom severity in IBS

Edogawa, S., Edwinson, A. L., Peters, S. A., Chikkamenahalli, L. L., Sundt, W., Graves, S., Gurunathan, S. V., Breen-Lyles, M., Johnson, S., Dyer, R., Graham, R., Chen, J., Kashyap, P., Farrugia, G. & Grover, M., Jan 1 2019, In : Gut.

Research output: Contribution to journalArticle

Serine Proteases
Microbiota
Permeability
Occludin
Healthy Volunteers
5 Citations (Scopus)

Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders

Saffouri, G. B., Shields-Cutler, R. R., Chen, J., Yang, Y., Lekatz, H. R., Hale, V. L., Cho, J. M., Battaglioli, E. J., Bhattarai, Y., Thompson, K. J., Kalari, K. K., Behera, G., Berry, J. C., Peters, S. A., Patel, R., Schuetz, A. N., Faith, J. J., Camilleri, M., Sonnenburg, J. L., Farrugia, G. & 4 others, Swann, J. R., Grover, M., Knights, D. & Kashyap, P. C., Dec 1 2019, In : Nature communications. 10, 1, 2012.

Research output: Contribution to journalArticle

Open Access
Dysbiosis
Gastrointestinal Diseases
Nutrition
diets
disorders
6 Citations (Scopus)

The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders

Shin, A., Preidis, G. A., Shulman, R. & Kashyap, P. C., Jan 1 2019, In : Clinical Gastroenterology and Hepatology. 17, 2, p. 256-274 19 p.

Research output: Contribution to journalReview article

Gastrointestinal Diseases
Microbiota
Pediatrics
Physiological Phenomena
Aptitude

The ‘in vivo lifestyle’ of bile acid 7α-dehydroxylating bacteria: comparative genomics, metatranscriptomic, and bile acid metabolomics analysis of a defined microbial community in gnotobiotic mice

Ridlon, J. M., Devendran, S., Alves, J. M., Doden, H., Wolf, P. G., Pereira, G. V., Ly, L., Volland, A., Takei, H., Nittono, H., Murai, T., Kurosawa, T., Chlipala, G. E., Green, S. J., Hernandez, A. G., Fields, C. J., Wright, C. L., Kakiyama, G., Cann, I., Kashyap, P. C. & 2 others, McCracken, V. & Gaskins, H. R., Jan 1 2019, In : Gut Microbes.

Research output: Contribution to journalArticle

Germ-Free Life
Metabolomics
Genomics
Bile Acids and Salts
Life Style
2018
11 Citations (Scopus)

Clostridioides difficile uses amino acids associated with gut microbial dysbiosis in a subset of patients with diarrhea

Battaglioli, E. J., Hale, V. L., Chen, J., Jeraldo, P., Ruiz-Mojica, C., Schmidt, B. A., Rekdal, V. M., Till, L. M., Huq, L., Smits, S. A., Moor, W. J., Jones-Hall, Y., Smyrk, T. C., Khanna, S., Pardi, D. S., Grover, M., Patel, R., Chia, N. D., Nelson, H., Sonnenburg, J. L. & 2 others, Farrugia, G. & Kashyap, P. C., Oct 24 2018, In : Science Translational Medicine. 10, 464, eaam7019.

Research output: Contribution to journalArticle

Dysbiosis
Diarrhea
Amino Acids
Infection
Proline

Diet Effects on Gut Microbiome Composition, Function, and Host Physiology

Battaglioli, E. J. & Kashyap, P. C., Mar 28 2018, Physiology of the Gastrointestinal Tract: Sixth Edition. Elsevier Inc., Vol. 1-2. p. 755-766 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Diet
Microbiota
Mass Spectrometry
Animal Models
Fats
12 Citations (Scopus)

Enterococcus faecalis sex pheromone cCF10 enhances conjugative plasmid transfer in vivo

Hirt, H., Greenwood-Quaintance, K. E., Karau, M. J., Till, L. M., Kashyap, P. C., Patel, R. & Dunny, G. M., Jan 1 2018, In : mBio. 9, 1, e00037-18.

Research output: Contribution to journalArticle

Sex Attractants
Enterococcus faecalis
Plasmids
Pheromones
Bacteriocins
8 Citations (Scopus)

Gut Microbial Carbohydrate Metabolism Hinders Weight Loss in Overweight Adults Undergoing Lifestyle Intervention With a Volumetric Diet

Muñiz Pedrogo, D. A., Jensen, M. D., Van Dyke, C. T., Murray, J. A., Woods, J. A., Chen, J., Kashyap, P. C. & Nehra, V., Aug 1 2018, In : Mayo Clinic Proceedings. 93, 8, p. 1104-1110 7 p.

Research output: Contribution to journalArticle

Carbohydrate Metabolism
Life Style
Weight Loss
Diet
Obesity
28 Citations (Scopus)

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion

Bhattarai, Y., Williams, B. B., Battaglioli, E. J., Whitaker, W. R., Till, L., Grover, M., Linden, D. R., Akiba, Y., Kandimalla, K. K., Zachos, N. C., Kaunitz, J. D., Sonnenburg, J. L., Fischbach, M. A., Farrugia, G. & Kashyap, P. C., Jun 13 2018, In : Cell Host and Microbe. 23, 6, p. 775-785.e5

Research output: Contribution to journalArticle

Receptors, Serotonin, 5-HT4
G-Protein-Coupled Receptors
Gastrointestinal Transit
Fluids and Secretions
Tryptophan
6 Citations (Scopus)

Increased Prevalence of Rare Sucrase-isomaltase (SI) Pathogenic Variants in Irritable Bowel Syndrome Patients

Garcia-Etxebarria, K., Zheng, T., Bonfiglio, F., Bujanda, L., Dlugosz, A., Lindberg, G., Schmidt, P. T., Karling, P., Ohlsson, B., Simren, M., Walter, S., Nardone, G., Cuomo, R., Usai-Satta, P., Galeazzi, F., Neri, M., Portincasa, P., Bellini, M., Barbara, G., Jonkers, D. & 10 others, Eswaran, S., Chey, W. D., Kashyap, P. C., Chang, L., Mayer, E. A., Wouters, M. M., Boeckxstaens, G., Camilleri, M., Franke, A. & D'Amato, M., Jan 1 2018, (Accepted/In press) In : Clinical Gastroenterology and Hepatology.

Research output: Contribution to journalArticle

Oligo-1,6-Glucosidase
Sucrase
Irritable Bowel Syndrome
Dietary Sucrose
Disaccharidases
8 Citations (Scopus)

Sex differences in NSAID-induced perturbation of human intestinal barrier function and microbiota

Edogawa, S., Peters, S. A., Jenkins, G. D., Gurunathan, S. V., Sundt, W. J., Johnson, S., Lennon, R. J., Dyer, R. B., Camilleri, M., Kashyap, P. C., Farrugia, G., Chen, J., Singh, R. J. & Grover, M., Dec 1 2018, In : FASEB Journal. 32, 12, p. 6615-6625 11 p.

Research output: Contribution to journalArticle

Microbiota
Non-Steroidal Anti-Inflammatory Agents
Indomethacin
Sex Characteristics
Permeability
56 Citations (Scopus)

US Immigration Westernizes the Human Gut Microbiome

Vangay, P., Johnson, A. J., Ward, T. L., Al-Ghalith, G. A., Shields-Cutler, R. R., Hillmann, B. M., Lucas, S. K., Beura, L. K., Thompson, E. A., Till, L. M., Batres, R., Paw, B., Pergament, S. L., Saenyakul, P., Xiong, M., Kim, A. D., Kim, G., Masopust, D., Martens, E. C., Angkurawaranon, C. & 4 others, McGready, R., Kashyap, P. C., Culhane-Pera, K. A. & Knights, D., Nov 1 2018, In : Cell. 175, 4, p. 962-972.e10

Research output: Contribution to journalArticle

Microbiota
Metabolic Diseases
Emigration and Immigration
Metagenomics
Firearms
2017

Beware! Are bacteria raising your oxidative stress?

Kashyap, P. C., Feb 22 2017, In : Science Translational Medicine. 9, 378

Research output: Contribution to journalArticle

Colonic Neoplasms
Oxidative Stress
Bacteria
Azoxymethane
Porphyromonas
31 Citations (Scopus)

Changes in microbial ecology after fecal microbiota transplantation for recurrent C. difficile infection affected by underlying inflammatory bowel disease

Khanna, S., Vazquez-Baeza, Y., González, A., Weiss, S., Schmidt, B., Muñiz-Pedrogo, D. A., Rainey, J. F., Kammer, P., Nelson, H., Sadowsky, M., Khoruts, A., Farrugia, S. L., Knight, R., Pardi, D. S. & Kashyap, P. C., May 15 2017, In : Microbiome. 5, 1, p. 55 1 p.

Research output: Contribution to journalArticle

Clostridium Infections
Clostridium difficile
Ecology
Inflammatory Bowel Diseases
Infection
12 Citations (Scopus)

Enterococcus faecalis readily colonizes the entire gastrointestinal tract and forms biofilms in a germ-free mouse model

Barnes, A. M. T., Dale, J. L., Chen, Y., Manias, D. A., Greenwood Quaintance, K. E., Karau, M. K., Kashyap, P. C., Patel, R., Wells, C. L. & Dunny, G. M., Feb 6 2017, (Accepted/In press) In : Virulence. p. 1-15 15 p.

Research output: Contribution to journalArticle

Enterococcus faecalis
Biofilms
Gastrointestinal Tract
Lower Gastrointestinal Tract
Bacteria
25 Citations (Scopus)

Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice

Allen, J. M., Mailing, L. J., Cohrs, J., Salmonson, C., Fryer, J. D., Nehra, V., Hale, V. L., Kashyap, P. C., White, B. A. & Woods, J. A., Sep 19 2017, (Accepted/In press) In : Gut Microbes. p. 1-16 16 p.

Research output: Contribution to journalArticle

Germ-Free Life
Microbiota
Colitis
Exercise
Tissue Donors
22 Citations (Scopus)
Receptors, Serotonin, 5-HT3
Serotonin
Acetates
Intestinal Secretions
Ondansetron

Metabolites and microbial composition of stool of women with fecal incontinence: Study design and methods

Arya, L. A., Richter, H. E., Jelovsek, E., Gantz, M., Cichowski, S., Zyczynski, H., Dyer, K., Siddiqui, N., Carberry, C., Broeckling, C., Morrow, C., Kashyap, P. C. & Meikle, S., 2017, (Accepted/In press) In : Neurourology and Urodynamics.

Research output: Contribution to journalArticle

Fecal Incontinence
Pelvic Floor Disorders
Loperamide
Specimen Handling
House Calls
24 Citations (Scopus)

Microbiome at the Frontier of Personalized Medicine

Kashyap, P. C., Chia, N. D., Nelson, H., Segal, E. & Elinav, E., Dec 1 2017, In : Mayo Clinic Proceedings. 92, 12, p. 1855-1864 10 p.

Research output: Contribution to journalReview article

Precision Medicine
Microbiota
Therapeutics
Human Genome
Health Care Costs
9 Citations (Scopus)

Mutual reinforcement of pathophysiological host-microbe interactions in intestinal stasis models

Touw, K., Ringus, D. L., Hubert, N., Wang, Y., Leone, V. A., Nadimpalli, A., Theriault, B. R., Huang, Y. E., Tune, J. D., Herring, P. B., Farrugia, G., Kashyap, P. C., Antonopoulos, D. A. & Chang, E. B., Mar 1 2017, In : Physiological Reports. 5, 6, e13182.

Research output: Contribution to journalArticle

Constipation
Loperamide
Microbiota
Dysbiosis
Gastrointestinal Transit
4 Citations (Scopus)

Screening for Clostridium difficile colonization on admission to a hematopoietic stem cell transplant unit may reduce hospital-acquired C difficile infection

Cho, J., Seville, M. T., Khanna, S., Pardi, D. S., Sampathkumar, P. & Kashyap, P. C., Jan 1 2017, (Accepted/In press) In : American Journal of Infection Control.

Research output: Contribution to journalArticle

Clostridium difficile
Hematopoietic Stem Cells
Transplants
Infection
Clostridium Infections

Tune into the rhythm of your bugs

Kashyap, P. C., Jan 11 2017, In : Science Translational Medicine. 9, 372, eaal4990.

Research output: Contribution to journalReview article

Epigenomics
Gastrointestinal Microbiome
2016
7 Citations (Scopus)

Agaro-oligosaccharides: A new frontier in the fight against colon cancer?

Bhattarai, Y. & Kashyap, P. C., Mar 15 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 310, 6, p. G335-G336

Research output: Contribution to journalEditorial

Dysbiosis
High Fat Diet
Oligosaccharides
Sepharose
Colonic Neoplasms
8 Citations (Scopus)
Microbiota
Weaning
Body Weight
Body Weight Changes
Somatomedins

Blow the germs away

Kashyap, P. C., Aug 31 2016, In : Science Translational Medicine. 8, 354, 354ec139.

Research output: Contribution to journalEditorial

Bugs clogging your arteries? Take an anti-B2 shot

Kashyap, P. C., Nov 23 2016, In : Science Translational Medicine. 8, 366, 2795.

Research output: Contribution to journalComment/debate

Arteries
2 Citations (Scopus)
Serotonin Receptors
Serotonin
Gene Expression
Free Association
Irritable Bowel Syndrome

Don't mix zinc lozenges and antibiotics

Kashyap, P. C., Oct 19 2016, In : Science Translational Medicine. 8, 361, 361ec167.

Research output: Contribution to journalComment/debate

Zinc
Anti-Bacterial Agents
12 Citations (Scopus)

Germ-free mice model for studying host–microbial interactions

Bhattarai, Y. & Kashyap, P. C., May 1 2016, In : Methods in Molecular Biology. 1438, p. 123-135 13 p.

Research output: Contribution to journalArticle

Germ-Free Life
Obesity
Health
26 Citations (Scopus)

Gut microbiome predictors of treatment response and recurrence in primary Clostridium difficile infection

Khanna, S., Montassier, E., Schmidt, B., Patel, R., Knights, D., Pardi, D. S. & Kashyap, P. C., 2016, (Accepted/In press) In : Alimentary Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Clostridium Infections
Clostridium difficile
Recurrence
Therapeutics
Area Under Curve
34 Citations (Scopus)

Gut microbiota: Modulation of host physiology in obesity

Nehra, V., Allen, J. M., Mailing, L. J., Kashyap, P. C. & Woods, J. A., Sep 1 2016, In : Physiology. 31, 5, p. 327-335 9 p.

Research output: Contribution to journalReview article

Microbiota
Obesity
Dysbiosis
Symbiosis
Adiposity
35 Citations (Scopus)

High risk of post-infectious irritable bowel syndrome in patients with Clostridium difficile infection

Wadhwa, A., Al Nahhas, M. F., Dierkhising, R. A., Patel, R., Kashyap, P. C., Pardi, D. S., Khanna, S. & Grover, M., Sep 1 2016, In : Alimentary Pharmacology and Therapeutics. 44, 6, p. 576-582 7 p.

Research output: Contribution to journalArticle

Clostridium Infections
Clostridium difficile
Irritable Bowel Syndrome
Odds Ratio
Anxiety

I'll have a Turkey and cheese sandwich

Kashyap, P. C., Jun 8 2016, In : Science Translational Medicine. 8, 342, 342ec91.

Research output: Contribution to journalComment/debate

Cheese
Turkey
17 Citations (Scopus)

Individualized responses of gut microbiota to dietary intervention modeled in humanized mice

Smits, S. A., Marcobal, A., Higginbottom, S., Sonnenburg, J. L. & Kashyap, P. C., Sep 1 2016, In : mSystems. 1, 5, e00098.

Research output: Contribution to journalArticle

Microbiota
Metabolites
intestinal microorganisms
Mouse
metabolite
13 Citations (Scopus)

Innovative gastric endoscopic muscle biopsy to identify all cell types, including myenteric neurons and interstitial cells of Cajal in patients with idiopathic gastroparesis: A feasibility study (with video)

Rajan, E., Gostout, C. J., Wong Kee Song, L. M., Szarka, L., Kashyap, P. C., Smyrk, T. C., Bingener, J., Deters, J. L., Knipschield, M. A., Bernard, C. E. & Farrugia, G., Feb 22 2016, (Accepted/In press) In : Gastrointestinal Endoscopy.

Research output: Contribution to journalArticle

Interstitial Cells of Cajal
Gastroparesis
Feasibility Studies
Stomach
Biopsy
12 Citations (Scopus)

Interleukin 10 Restores Gastric Emptying, Electrical Activity, and Interstitial Cells of Cajal Networks in Diabetic Mice

Choi, K. M., Gibbons, S. J., Sha, L., Beyder, A., Verhulst, P. J., Cipriani, G., Phillips, J. E., Bauer, A. J., Ordog, T., Camp, J. J., Ge, X., Bharucha, A. E., Linden, D. R., Szurszewski, J. H., Kashyap, P. C. & Farrugia, G., Jul 1 2016, In : CMGH Cellular and Molecular Gastroenterology and Hepatology. 2, 4, p. 454-467 14 p.

Research output: Contribution to journalArticle

Interstitial Cells of Cajal
Gastric Emptying
Interleukin-10
Heme Oxygenase-1
Stomach
24 Citations (Scopus)

Intrinsic Gastrointestinal Macrophages: Their Phenotype and Role in Gastrointestinal Motility

Cipriani, G., Gibbons, S. J., Kashyap, P. C. & Farrugia, G., Feb 1 2016, In : CMGH Cellular and Molecular Gastroenterology and Hepatology. 2, 2, p. 120-130.e1

Research output: Contribution to journalReview article

Gastrointestinal Motility
Macrophages
Phenotype
Gastroparesis
Ileus
40 Citations (Scopus)

Irritable bowel syndrome: A gut microbiota-related disorder?

Bhattarai, Y., Muniz Pedrogo, D. A. & Kashyap, P. C., Nov 23 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 312, 1, p. G52-G62

Research output: Contribution to journalReview article

Irritable Bowel Syndrome
Causality
Gastrointestinal Motility
Life Change Events
Gastrointestinal Microbiome

Keep it moving

Kashyap, P. C., Aug 3 2016, In : Science Translational Medicine. 8, 350, p. 350ec125

Research output: Contribution to journalShort survey

39 Citations (Scopus)

Mechanosensitive ion channel Piezo2 is important for enterochromaffin cell response to mechanical forces

Wang, F., Knutson, K., Alcaino, C., Linden, D. R., Gibbons, S. J., Kashyap, P. C., Grover, M., Oeckler, R., Gottlieb, P. A., Li, H. J., Leiter, A. B., Farrugia, G. & Beyder, A., 2016, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

Enterochromaffin Cells
Ion Channels
Serotonin
Epithelium
Jejunum

Microbes make the cancer

Kashyap, P. C., May 4 2016, In : Science Translational Medicine. 8, 337

Research output: Contribution to journalEditorial

Neoplasms
2015
3 Citations (Scopus)

A clinical primer of the role of gut microbiome in health and disease

Yang, A. L. & Kashyap, P. C., Jan 1 2015, In : Tropical gastroenterology : official journal of the Digestive Diseases Foundation. 36, 1, p. 1-13 13 p.

Research output: Contribution to journalReview article

Health
Gastrointestinal Diseases
Vitamins
Fermentation
Gastrointestinal Tract
1 Citation (Scopus)

Eat Your Curry

Kashyap, P. C., Oct 14 2015, In : Cell Host and Microbe. 18, 4, p. 385-387 3 p., 1349.

Research output: Contribution to journalShort survey

Bacteria
Curcuma
Gastrointestinal Motility
225 Citations (Scopus)

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

Reigstad, C. S., Salmonson, C. E., Rainey, J. F., Szurszewski, J. H., Linden, D. R., Sonnenburg, J. L., Farrugia, G. & Kashyap, P. C., Apr 1 2015, In : FASEB Journal. 29, 4, p. 1395-1403 9 p.

Research output: Contribution to journalArticle

Enterochromaffin Cells
Volatile Fatty Acids
Serotonin
Gastrointestinal Motility
Receptors, Serotonin, 5-HT4
244 Citations (Scopus)

Update on Fecal Microbiota Transplantation 2015: Indications, Methodologies, Mechanisms, and Outlook

Kelly, C. R., Kahn, S., Kashyap, P. C., Laine, L., Rubin, D., Atreja, A., Moore, T. & Wu, G., Jul 1 2015, In : Gastroenterology. 149, 1, p. 223-237 15 p., 59779.

Research output: Contribution to journalLetter

Clostridium Infections
Clostridium difficile
Safety
Microbial Consortia
Dysbiosis
2014
124 Citations (Scopus)

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine

Williams, B. B., Van Benschoten, A. H., Cimermancic, P., Donia, M. S., Zimmermann, M., Taketani, M., Ishihara, A., Kashyap, P. C., Fraser, J. S. & Fischbach, M. A., Oct 8 2014, In : Cell Host and Microbe. 16, 4, p. 495-503 9 p.

Research output: Contribution to journalArticle

Aromatic-L-Amino-Acid Decarboxylases
Carboxy-Lyases
Neurotransmitter Agents
Tryptophan
Gastrointestinal Microbiome