Prashanthi D Vemuri, PhD

  • 12047 Citations
  • 59 Scopus h-Index
20042020

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Cognitive reserve and Alzheimer's disease biomarkers are independent determinants of cognition

Vemuri, P., Weigand, S. D., Przybelski, S. A., Knopman, D. S., Smith, G. E., Trojanowski, J. Q., Shaw, L. M., Decarli, C. S., Carmichael, O., Bernstein, M. A., Aisen, P. S., Weiner, M., Petersen, R. C. & Jack, C. R., May 2011, In : Brain. 134, 5, p. 1479-1492 14 p.

Research output: Contribution to journalArticle

88 Scopus citations

Comparison of variables associated with cerebrospinal fluid neurofilament, total-tau, and neurogranin

Mielke, M. M., Syrjanen, J. A., Blennow, K., Zetterberg, H., Skoog, I., Vemuri, P., Machulda, M. M., Graff-Radford, J., Knopman, D. S., Jack, C. R., Petersen, R. C. & Kern, S., Nov 2019, In : Alzheimer's and Dementia. 15, 11, p. 1437-1447 11 p.

Research output: Contribution to journalArticle

Considerations for performing level-2 centiloid transformations for amyloid PET SUVR values

Schwarz, C., Tosakulwong, N., Senjem, M. L., Gunter, J. L., Therneau, T. M., Vemuri, P. D., Lowe, V. & Jack, C. R. J., Dec 1 2018, In : Scientific Reports. 8, 1, 7421.

Research output: Contribution to journalArticle

1 Scopus citations
13 Scopus citations

Cortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging

Machulda, M. M., Lundt, E. S., Albertson, S. M., Spychalla, A. J., Schwarz, C. G., Mielke, M. M., Jack, C. R., Kremers, W. K., Vemuri, P., Knopman, D. S., Jones, D. T., Bondi, M. W. & Petersen, R. C., Jul 1 2020, In : Alzheimer's and Dementia. 16, 7, p. 1013-1022 10 p.

Research output: Contribution to journalArticle

Open Access

Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging

Krell-Roesch, J., Vassilaki, M., Mielke, M. M., Kremers, W. K., Lowe, V. J., Vemuri, P., Machulda, M. M., Christianson, T. J., Syrjanen, J. A., Stokin, G. B., Butler, L. M., Traber, M., Jack, C. R., Knopman, D. S., Roberts, R. O., Petersen, R. C. & Geda, Y. E., Dec 1 2019, In : Translational psychiatry. 9, 1, 123.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults

Lowe, V. J., Bruinsma, T. J., Wiste, H. J., Min, H. K., Weigand, S. D., Fang, P., Senjem, M. L., Therneau, T. M., Boeve, B. F., Josephs, K. A., Pandey, M. K., Murray, M. E., Kantarci, K., Jones, D. T., Vemuri, P., Graff-Radford, J., Schwarz, C. G., Machulda, M. M., Mielke, M. M., Roberts, R. O. & 3 others, Knopman, D. S., Petersen, R. C. & Jack, C. R., Jul 2 2019, In : Neurology. 93, 1, p. E29-E39

Research output: Contribution to journalArticle

6 Scopus citations

Defining imaging biomarker cut points for brain aging and Alzheimer's disease

Jack, C. R. J., Wiste, H. J., Weigand, S. D., Therneau, T. M., Lowe, V., Knopman, D. S., Gunter, J. L., Senjem, M. L., Jones, D. T., Kantarci, K. M., Machulda, M. M., Mielke, M. M., Roberts, R. O., Vemuri, P. D., Reyes, D. A. & Petersen, R. C., 2016, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

147 Scopus citations

Dementia with Lewy bodies and Alzheimer disease: Neurodegenerative patterns characterized by DTI

Kantarci, K., Avula, R., Senjem, M. L., Samikoglu, A. R., Zhang, B., Weigand, S. D., Przybelski, S. A., Edmonson, H. A., Vemuri, P., Knopman, D. S., Ferman, T. J., Boeve, B. F., Petersen, R. C. & Jack, C. R., Jun 1 2010, In : Neurology. 74, 22, p. 1814-1821 8 p.

Research output: Contribution to journalArticle

129 Scopus citations

Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons: the Mayo Clinic Study of Aging

Krell-Roesch, J., Lowe, V., Neureiter, J., Pink, A., Roberts, R. O., Mielke, M. M., Vemuri, P. D., Stokin, G. B., Christianson, T. J., Jack, C. R. J., Knopman, D. S., Boeve, B. F., Kremers, W. K., Petersen, R. C. & Geda, Y. E., Dec 4 2017, (Accepted/In press) In : International Psychogeriatrics. p. 1-7 7 p.

Research output: Contribution to journalArticle

12 Scopus citations

Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging

Vemuri, P. D., Lesnick, T. G., Przybelski, S. A., Graff-Radford, J., Reid, R. I., Lowe, V., Zuk, S. M., Senjem, M. L., Schwarz, C., Gunter, J. L., Kantarci, K. M., Machulda, M. M., Mielke, M. M., Petersen, R. C., Knopman, D. S. & Jack, C. R. J., Jan 1 2018, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

9 Scopus citations

Different definitions of neurodegeneration produce similar amyloid/neurodegeneration biomarker group findings

Jack, C. R., Wiste, H. J., Weigand, S. D., Knopman, D. S., Mielke, M. M., Vemuri, P., Lowe, V., Senjem, M. L., Gunter, J. L., Reyes, D., Machulda, M. M., Roberts, R. & Petersen, R. C., Dec 1 2015, In : Brain. 138, 12, p. 3747-3759 13 p.

Research output: Contribution to journalArticle

78 Scopus citations

Diffusion tensor imaging and cognitive function in older adults with no dementia

Kantarci, K., Senjem, M. L., Avula, R., Zhang, B., Samikoglu, A. R., Weigand, S. D., Przybelski, S. A., Edmonson, H. A., Vemuri, P., Knopman, D. S., Boeve, B. F., Ivnik, R. J., Smith, G. E., Petersen, R. C. & Jack, C. R., Jul 5 2011, In : Neurology. 77, 1, p. 26-34 9 p.

Research output: Contribution to journalArticle

100 Scopus citations

Disrupted thalamocortical connectivity in PSP: A resting-state fMRI, DTI, and VBM study

Whitwell, J. L., Avula, R., Master, A., Vemuri, P., Senjem, M. L., Jones, D. T., Jack, C. R. & Josephs, K. A., Sep 1 2011, In : Parkinsonism and Related Disorders. 17, 8, p. 599-605 7 p.

Research output: Contribution to journalArticle

101 Scopus citations

Distinct anatomical subtypes of the behavioural variant of frontotemporal dementia: A cluster analysis study

Whitwell, J. L., Przybelski, S. A., Weigand, S. D., Ivnik, R. J., Vemuri, P., Gunter, J. L., Senjem, M. L., Shiung, M. M., Boeve, B. F., Knopman, D. S., Parisi, J. E., Dickson, D. W., Petersen, R. C., Jack, C. R. & Josephs, K. A., Nov 2009, In : Brain. 132, 11, p. 2932-2946 15 p.

Research output: Contribution to journalArticle

180 Scopus citations

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

The Alzheimer's Disease Neuroimaging Initiative, Jun 21 2016, In : Nature communications. 7, 11934.

Research output: Contribution to journalArticle

284 Scopus citations

Effect of APOE ε4 status on intrinsic network connectivity in cognitively normal elderly subjects

Machulda, M. M., Jones, D. T., Vemuri, P., McDade, E., Avula, R., Przybelski, S., Boeve, B. F., Knopman, D. S., Petersen, R. C. & Jack, C. R., Sep 1 2011, In : Archives of neurology. 68, 9, p. 1131-1136 6 p.

Research output: Contribution to journalArticle

156 Scopus citations

Effect of apolipoprotein E on biomarkers of amyloid load and neuronal pathology in Alzheimer disease

Vemuri, P., Wiste, H. J., Weigand, S. D., Knopman, D. S., Shaw, L. M., Trojanowski, J. Q., Aisen, P. S., Weiner, M., Petersen, R. C. & Jack, C. R., Mar 2010, In : Annals of neurology. 67, 3, p. 308-316 9 p.

Research output: Contribution to journalArticle

123 Scopus citations

Effect of intellectual enrichment on AD biomarker trajectories

Vemuri, P., Lesnick, T. G., Przybelski, S. A., Knopman, D. S., Machulda, M., Lowe, V. J., Mielke, M. M., Roberts, R. O., Gunter, J. L., Senjem, M. L., Geda, Y. E., Rocca, W. A., Petersen, R. C. & Jack, C. R., Mar 22 2016, In : Neurology. 86, 12, p. 1128-1135 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Effect of lifestyle activities on alzheimer disease biomarkers and cognition

Vemuri, P., Lesnick, T. G., Przybelski, S. A., Knopman, D. S., Roberts, R. O., Lowe, V. J., Kantarci, K., Senjem, M. L., Gunter, J. L., Boeve, B. F., Petersen, R. C. & Jack, C. R., Nov 1 2012, In : Annals of neurology. 72, 5, p. 730-738 9 p.

Research output: Contribution to journalArticle

96 Scopus citations

Effects of hardware heterogeneity on the performance of SVM Alzheimer's disease classifier

Abdulkadir, A., Mortamet, B., Vemuri, P., Jack, C. R., Krueger, G. & Klöppel, S., Oct 1 2011, In : NeuroImage. 58, 3, p. 785-792 8 p.

Research output: Contribution to journalArticle

56 Scopus citations

Effects of hormone therapy on brain structure

Kantarci, K., Tosakulwong, N., Lesnick, T. G., Zuk, S. M., Gunter, J. L., Gleason, C. E., Wharton, W., Dowling, N. M., Vemuri, P., Senjem, M. L., Shuster, L. T., Bailey, K. R., Rocca, W. A., Jack, C. R., Asthana, S. & Miller, V. M., Aug 30 2016, In : Neurology. 87, 9, p. 887-896 10 p.

Research output: Contribution to journalArticle

18 Scopus citations
18 Scopus citations
50 Scopus citations

Evidence for ordering of Alzheimer disease biomarkers

Jack, C. R., Vemuri, P., Wiste, H. J., Weigand, S. D., Aisen, P. S., Trojanowski, J. Q., Shaw, L. M., Bernstein, M. A., Petersen, R. C., Weiner, M. W. & Knopman, D. S., Dec 1 2011, In : Archives of neurology. 68, 12, p. 1526-1535 10 p.

Research output: Contribution to journalArticle

166 Scopus citations

Evolution of neurodegeneration-imaging biomarkers from clinically normal to dementia in the Alzheimer disease spectrum

Knopman, D. S., Jack, C. R. J., Lundt, E. S., Weigand, S. D., Vemuri, P. D., Lowe, V., Kantarci, K. M., Gunter, J. L., Senjem, M. L., Mielke, M. M., Machulda, M. M., Roberts, R. O., Boeve, B. F., Jones, D. T. & Petersen, R. C., Oct 1 2016, In : Neurobiology of Aging. 46, p. 32-42 11 p.

Research output: Contribution to journalArticle

7 Scopus citations
24 Scopus citations

Exposure to surgery under general anaesthesia and brain magnetic resonance imaging changes in older adults

Sprung, J., Kruthiventi, S. C., Warner, D. O., Knopman, D. S., Petersen, R. C., Mielke, M. M., Jack, C. R., Graff-Radford, J., Martin, D. P., Hanson, A. C., Schroeder, D. R., Przybelski, S. A., Schulte, P. J., Weingarten, T. N. & Vemuri, P., Dec 2019, In : British journal of anaesthesia. 123, 6, p. 808-817 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Exposure to surgery with general anaesthesia during adult life is not associated with increased brain amyloid deposition in older adults

Sprung, J., Warner, D. O., Knopman, D. S., Petersen, R. C., Mielke, M. M., Jack, C. R., Lowe, V. J., Martin, D. P., Hanson, A. C., Schroeder, D. R., Przybelski, S. A., Schulte, P. J., Weingarten, T. N. & Vemuri, P., May 2020, In : British journal of anaesthesia. 124, 5, p. 594-602 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

FAM222A encodes a protein which accumulates in plaques in Alzheimer’s disease

The Alzheimer Disease Neuroimaging Initiative, Dec 1 2020, In : Nature communications. 11, 1, 411.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

Alzheimer's Disease Neuroimaging Initiative, May 19 2015, In : Nature communications. 6, 6760.

Research output: Contribution to journalArticle

110 Scopus citations

Focal atrophy on MRI and neuropathologic classification of dementia with Lewy bodies

Kantarci, K., Ferman, T. J., Boeve, B. F., Weigand, S. D., Przybelski, S., Vemuri, P., Murray, M. M., Senjem, M. L., Smith, G. E., Knopman, D. S., Petersen, R. C., Jack, C. R., Parisi, J. E. & Dickson, D. W., Aug 7 2012, In : Neurology. 79, 6, p. 553-560 8 p.

Research output: Contribution to journalArticle

61 Scopus citations
1 Scopus citations

Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

Alzheimer’s Disease Neuroimaging Initiative (ADNI), Dec 1 2020, In : Nature communications. 11, 1, 347.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Gray and white matter water diffusion in the syndromic variants of frontotemporal dementia

Whitwell, J. L., Avula, R., Senjem, M. L., Kantarci, K., Weigand, S. D., Samikoglu, A., Edmonson, H. A., Vemuri, P., Knopman, D. S., Boeve, B. F., Petersen, R. C., Josephs, K. A. & Jack, C. R., Apr 2010, In : Neurology. 74, 16, p. 1279-1287 9 p.

Research output: Contribution to journalArticle

168 Scopus citations

Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study

Mielke, M. M., Savica, R., Wiste, H. J., Weigand, S. D., Vemuri, P., Knopman, D. S., Lowe, V. J., Roberts, R. O., Machulda, M. M., Geda, Y. E., Petersen, R. C. & Jack, C. R., Jan 7 2014, In : Neurology. 82, 1, p. 70-76 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Imaging and acetylcholinesterase inhibitor response in dementia with Lewy bodies

Graff-Radford, J., Boeve, B. F., Pedraza, O., Ferman, T. J., Przybelski, S., Lesnick, T. G., Vemuri, P., Senjem, M. L., Smith, G. E., Knopman, D. S., Lowe, V., Jack, C. R., Petersen, R. C. & Kantarci, K., Aug 2012, In : Brain. 135, 8, p. 2470-2477 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Imaging Biomarkers of Alzheimer Disease in Multiple Sclerosis

Zeydan, B., Lowe, V. J., Reichard, R. R., Przybelski, S. A., Lesnick, T. G., Schwarz, C. G., Senjem, M. L., Gunter, J. L., Parisi, J. E., Machulda, M. M., Vemuri, P., Mielke, M. M., Knopman, D. S., Petersen, R. C., Jack, C. R., Kantarci, O. H. & Kantarci, K., Apr 1 2020, In : Annals of neurology. 87, 4, p. 556-567 12 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
18 Scopus citations

Improved DTI registration allows voxel-based analysis that outperforms Tract-Based Spatial Statistics

Schwarz, C. G., Reid, R. I., Gunter, J. L., Senjem, M. L., Przybelski, S. A., Zuk, S. M., Whitwell, J. L., Vemuri, P., Josephs, K. A., Kantarci, K., Thompson, P. M., Petersen, R. C. & Jack, C. R., Jul 1 2014, In : NeuroImage. 94, p. 65-78 14 p.

Research output: Contribution to journalArticle

92 Scopus citations
16 Scopus citations

Indicators of amyloid burden in a population-based study of cognitively normal elderly

Mielke, M. M., Wiste, H. J., Weigand, S. D., Knopman, D. S., Lowe, V. J., Roberts, R. O., Geda, Y. E., Swenson-Dravis, D. M., Boeve, B. F., Senjem, M. L., Vemuri, P., Petersen, R. C. & Jack, C. R., Oct 9 2012, In : Neurology. 79, 15, p. 1570-1577 8 p.

Research output: Contribution to journalArticle

97 Scopus citations

Influence of amyloid and APOE on cognitive performance in a late middle-aged cohort

Mielke, M. M., Machulda, M. M., Hagen, C. E., Christianson, T. J., Roberts, R. O., Knopman, D. S., Vemuri, P. D., Lowe, V., Kremers, W. K., Jack, C. R. J. & Petersen, R. C., 2015, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

19 Scopus citations

Investigation of white matter PiB uptake as a marker of white matter integrity

Zeydan, B., Schwarz, C. G., Lowe, V. J., Reid, R. I., Przybelski, S. A., Lesnick, T. G., Kremers, W. K., Senjem, M. L., Gunter, J. L., Min, H. K., Vemuri, P., Knopman, D. S., Petersen, R. C., Jack, C. R., Kantarci, O. H. & Kantarci, K., Apr 2019, In : Annals of Clinical and Translational Neurology. 6, 4, p. 678-688 11 p.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Joint associations of β-amyloidosis and cortical thickness with cognition

Knopman, D. S., Lundt, E. S., Therneau, T. M., Vemuri, P. D., Lowe, V., Kantarci, K. M., Gunter, J. L., Senjem, M. L., Mielke, M. M., Machulda, M. M., Roberts, R. O., Boeve, B. F., Jones, D. T., Petersen, R. C. & Jack, C. R. J., May 1 2018, In : Neurobiology of Aging. 65, p. 121-131 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

Large-scale genomics unveil polygenic architecture of human cortical surface area

Chen, C. H., Peng, Q., Schork, A. J., Lo, M. T., Fan, C. C., Wang, Y., Desikan, R. S., Bettella, F., Hagler, D. J., Westlye, L. T., Kremen, W. S., Jernigan, T. L., Le Hellard, S., Steen, V. M., Espeseth, T., Huentelman, M., Håberg, A. K., Agartz, I., Djurovic, S., Andreassen, O. A. & 86 others, Schork, N., Dale, A. M., McCabe, C., Chang, L., Akshoomoff, N., Newman, E., Ernst, T., Van Zijl, P., Kuperman, J., Murray, S., Bloss, C., Appelbaum, M., Gamst, A., Thompson, W., Bartsch, H., Weiner, M., Aisen, P., Petersen, R., Jack, C. R., Jagust, W., Trojanowki, J. Q., Toga, A. W., Beckett, L., Green, R. C., Saykin, A. J., Morris, J., Shaw, L. M., Khachaturian, Z., Sorensen, G., Carrillo, M., Kuller, L., Raichle, M., Paul, S., Davies, P., Fillit, H., Hefti, F., Holtzman, D., Mesulman, M. M., Potter, W., Snyder, P. J., Schwartz, A., Montine, T., Thomas, R. G., Donohue, M., Walter, S., Gessert, D., Sather, T., Jiminez, G., Harvey, D., Bernstein, M., Fox, N., Thompson, P., Schuff, N., DeCarli, C., Borowski, B., Gunter, J., Senjem, M., Vemuri, P., Jones, D., Kantarci, K., Ward, C., Koeppe, R. A., Foster, N., Reiman, E. M., Chen, K., Mathis, C., Landau, S., Cairns, N. J., Householder, E., Taylor-Reinwald, L., Lee, V. M. Y., Korecka, M., Figurski, M., Crawford, K., Neu, S., Foroud, T. M., Potkin, S., Shen, L., Faber, K., Kim, S., Nho, K., Thal, L., Frank, R., Buckholtz, N., Albert, M. & Hsiao, J., Jul 20 2015, In : Nature communications. 6, 7549.

Research output: Contribution to journalArticle

22 Scopus citations

Longitudinal association between brain amyloid-beta and gait in the mayo clinic study of aging

Wennberg, A. M. V., Lesnick, T. G., Schwarz, C., Savica, R., Hagen, C. E., Roberts, R. O., Knopman, D. S., Hollman, J. H., Vemuri, P. D., Jack, C. R. J., Petersen, R. C. & Mielke, M. M., Jan 1 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 9, p. 1244-1250 7 p.

Research output: Contribution to journalArticle

6 Scopus citations
3 Scopus citations