Prashanthi D Vemuri, PhD

  • 10366 Citations
  • 54 Scopus h-Index
19992021
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Research Output 2004 2019

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57 Citations (Scopus)

18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons

Knopman, D. S., Jack, C. R. J., Wiste, H. J., Lundt, E. S., Weigand, S. D., Vemuri, P. D., Lowe, V., Kantarci, K. M., Gunter, J. L., Senjem, M. L., Mielke, M. M., Roberts, R. O., Boeve, B. F. & Petersen, R. C., 2014, In : Neurobiology of Aging. 35, 9, p. 2096-2106 11 p.

Research output: Contribution to journalArticle

Apolipoprotein E4
Fluorodeoxyglucose F18
Apolipoproteins E
Positron-Emission Tomography
Genotype
11 Citations (Scopus)

Accelerated vs. unaccelerated serial MRI based TBM-SyN measurements for clinical trials in Alzheimer's disease

Alzheimer's Disease Neuroimaging Initiative, Jun 1 2015, In : NeuroImage. 113, p. 61-69 9 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Clinical Trials
Sample Size
Neuroimaging
Disease Progression
2 Citations (Scopus)

A Comparison of Partial Volume Correction Techniques for Measuring Change in Serial Amyloid PET SUVR

Schwarz, C., Gunter, J. L., Lowe, V., Weigand, S., Vemuri, P. D., Senjem, M. L., Petersen, R. C., Knopman, D. S. & Jack, C. R. J., Jan 1 2019, In : Journal of Alzheimer's Disease. 67, 1, p. 181-195 15 p.

Research output: Contribution to journalArticle

Amyloid
Positron-Emission Tomography
Longitudinal Studies
Noise
Alzheimer Disease
134 Citations (Scopus)

Age, sex, and APOE ϵ4 effects on memory, brain structure, and β-Amyloid across the adult life Span

Jack, C. R. J., Wiste, H. J., Weigand, S. D., Knopman, D. S., Vemuri, P. D., Mielke, M. M., Lowe, V., Senjem, M. L., Gunter, J. L., Machulda, M. M., Gregg, B. E., Pankratz, V. S., Rocca, W. A. & Petersen, R. C., May 1 2015, In : JAMA Neurology. 72, 5, p. 511-519 9 p.

Research output: Contribution to journalArticle

Amyloid
Positron-Emission Tomography
Brain
Amyloidosis
Amyloid Plaques
43 Citations (Scopus)

Age, vascular health, and Alzheimer disease biomarkers in an elderly sample

Vemuri, P. D., Lesnick, T. G., Przybelski, S. A., Knopman, D. S., Lowe, V., Graff-Radford, J., Roberts, R. O., Mielke, M. M., Machulda, M. M., Petersen, R. C. & Jack, C. R. J., 2017, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

Vascular Diseases
Amyloid
Alzheimer Disease
Positron-Emission Tomography
Biomarkers
13 Citations (Scopus)

Age and neurodegeneration imaging biomarkers in persons with Alzheimer disease dementia

Knopman, D. S., Jack, C. R. J., Wiste, H. J., Weigand, S. D., Vemuri, P. D., Lowe, V., Kantarci, K. M., Gunter, J. L., Senjem, M. L., Mielke, M. M., Machulda, M. M., Roberts, R. O., Boeve, B. F., Jones, D. T. & Petersen, R. C., Aug 16 2016, In : Neurology. 87, 7, p. 691-698 8 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Biomarkers
Fluorodeoxyglucose F18
Amyloid
Research Design
182 Citations (Scopus)

Age-related changes in the default mode network are more advanced in Alzheimer disease

Jones, D. T., Machulda, M. M., Vemuri, P. D., McDade, E. M., Zeng, G., Senjem, M. L., Gunter, J. L., Przybelski, S. A., Avula, R. T., Knopman, D. S., Boeve, B. F., Petersen, R. C. & Jack, C. R. J., Oct 18 2011, In : Neurology. 77, 16, p. 1524-1531 8 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Education
Frontal Lobe
Atrophy
Alleles
78 Citations (Scopus)
Tauopathies
Amyloid
Cross-Sectional Studies
Biomarkers
Medical Record Linkage
184 Citations (Scopus)

Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50-89 years: A cross-sectional study

Jack, C. R. J., Wiste, H. J., Weigand, S. D., Rocca, W. A., Knopman, D. S., Mielke, M. M., Lowe, V., Senjem, M. L., Gunter, J. L., Preboske, G. M., Pankratz, V. S., Vemuri, P. D. & Petersen, R. C., Oct 1 2014, In : The Lancet Neurology. 13, 10, p. 997-1005 9 p.

Research output: Contribution to journalArticle

Amyloid
Cognition
Cross-Sectional Studies
Alzheimer Disease
Population
50 Citations (Scopus)

A large-scale comparison of cortical thickness and volume methods for measuring Alzheimer's disease severity

Schwarz, C., Gunter, J. L., Wiste, H. J., Przybelski, S. A., Weigand, S. D., Ward, C. P., Senjem, M. L., Vemuri, P. D., Murray, M. E., Dickson, D. W., Parisi, J. E., Kantarci, K. M., Weiner, M. W., Petersen, R. C. & Jack, C. R. J., 2016, In : NeuroImage: Clinical. 11, p. 802-812 11 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Neurofibrillary Tangles
Head
Autopsy
Parietal Lobe
82 Citations (Scopus)

Altered functional connectivity in asymptomatic MAPT subjects A comparison to bvFTD

Whitwell, J. L., Josephs, K. A., Avula, R., Tosakulwong, N., Weigand, S. D., Senjem, M. L., Vemuri, P. D., Jones, D. T., Gunter, J. L., Baker, M., Wszolek, Z. K., Knopman, D. S., Rademakers, R. V., Petersen, R. C., Boeve, B. F. & Jack, C. R. J., Aug 30 2011, In : Neurology. 77, 9, p. 866-874 9 p.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Microtubule-Associated Proteins
Parietal Lobe
Temporal Lobe
Cerebral Cortex
300 Citations (Scopus)

Alzheimer's disease diagnosis in individual subjects using structural MR images: Validation studies

Vemuri, P. D., Gunter, J. L., Senjem, M. L., Whitwell, J. L., Kantarci, K. M., Knopman, D. S., Boeve, B. F., Petersen, R. C. & Jack, C. R. J., Feb 1 2008, In : NeuroImage. 39, 3, p. 1186-1197 12 p.

Research output: Contribution to journalArticle

Validation Studies
Alzheimer Disease
Libraries
Demography
Apolipoproteins E
118 Citations (Scopus)

Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity

Jack, C. R. J., Wiste, H. J., Weigand, S. D., Knopman, D. S., Lowe, V., Vemuri, P. D., Mielke, M. M., Jones, D. T., Senjem, M. L., Gunter, J. L., Gregg, B. E., Pankratz, V. S. & Petersen, R. C., Nov 12 2013, In : Neurology. 81, 20, p. 1732-1740 9 p.

Research output: Contribution to journalArticle

Amyloid
Positivity
Alzheimer Disease
Imaging
Incidence
2 Citations (Scopus)

Amyloid-β — a reflection of risk or a preclinical marker?

Jack, C. R. J. & Vemuri, P. D., Apr 30 2018, (Accepted/In press) In : Nature Reviews Neurology. p. 1-2 2 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Biomarkers
Brain
Cognitive Dysfunction
375 Citations (Scopus)

An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease

Jack, C. R. J., Knopman, D. S., Weigand, S. D., Wiste, H. J., Vemuri, P. D., Lowe, V., Kantarci, K. M., Gunter, J. L., Senjem, M. L., Ivnik, R. J., Roberts, R. O., Rocca, W. A., Boeve, B. F. & Petersen, R. C., Jun 2012, In : Annals of Neurology. 71, 6, p. 765-775 11 p.

Research output: Contribution to journalArticle

National Institute on Aging (U.S.)
Alzheimer Disease
Biomarkers
Positron-Emission Tomography
Population
61 Citations (Scopus)

Antemortem differential diagnosis of dementia pathology using structural MRI: Differential-STAND

Vemuri, P. D., Simon, G., Kantarci, K. M., Whitwell, J. L., Senjem, M. L., Przybelski, S. A., Gunter, J. L., Josephs, K. A., Knopman, D. S., Boeve, B. F., Ferman, T. J., Dickson, D. W., Parisi, J. E., Petersen, R. C. & Jack, C. R. J., Mar 15 2011, In : NeuroImage. 55, 2, p. 522-531 10 p.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Lewy Body Disease
Dementia
Differential Diagnosis
Pathology
113 Citations (Scopus)
Neurofibrillary Tangles
Magnetic Resonance Imaging
Alzheimer Disease
Atrophy
Pathology
29 Citations (Scopus)

Antemortem MRI findings associated with microinfarcts at autopsy

Raman, M. R., Preboske, G. M., Przybelski, S. A., Gunter, J. L., Senjem, M. L., Vemuri, P. D., Murphy, M., Murray, M. E., Boeve, B. F., Knopman, D. S., Petersen, R. C., Parisi, J. E., Dickson, D. W., Jack, C. R. J. & Kantarci, K. M., Jun 3 2014, In : Neurology. 82, 22, p. 1951-1958 8 p.

Research output: Contribution to journalArticle

Autopsy
Atrophy
Brain
Alzheimer Disease
Research Design
32 Citations (Scopus)

Application of the national institute on aging-alzheimer's association AD criteria to ADNI

Lowe, V., Peller, P. J., Weigand, S. D., Quintero, C. M., Tosakulwong, N., Vemuri, P. D., Senjem, M. L., Jordan, L., Jack, C. R. J., Knopman, D. S. & Petersen, R. C., Jun 4 2013, In : Neurology. 80, 23, p. 2130-2137 8 p.

Research output: Contribution to journalArticle

National Institute on Aging (U.S.)
Neuroimaging
Alzheimer Disease
Biomarkers
Amyloid
41 Citations (Scopus)
Myelin Basic Protein
Oligodendroglia
Pathology
Extracellular Fluid
Brain
79 Citations (Scopus)

Association between anticholinergic medication use and cognition, brain metabolism, and brain atrophy in cognitively normal older adults

Alzheimer's Disease Neuroimaging Initiative, Jun 1 2016, In : JAMA Neurology. 73, 6, p. 721-732 12 p.

Research output: Contribution to journalArticle

Cholinergic Antagonists
Cognition
Atrophy
Brain
Neuroimaging
2 Citations (Scopus)
Dementia
Alzheimer Disease
Biomarkers
Amyloid
Neuroimaging
16 Citations (Scopus)

Association between mentally stimulating activities in late life and the outcome of incident mild cognitive impairment, with an analysis of the APOE ϵ4 genotype

Krell-Roesch, J., Vemuri, P. D., Pink, A., Roberts, R. O., Stokin, G. B., Mielke, M. M., Christianson, T. J. H., Knopman, D. S., Petersen, R. C., Kremers, W. K. & Geda, Y. E., Mar 1 2017, In : JAMA Neurology. 74, 3, p. 332-338 7 p.

Research output: Contribution to journalArticle

Apolipoprotein E4
Genotype
Cognitive Dysfunction
Proportional Hazards Models
Consensus
27 Citations (Scopus)
Gyrus Cinguli
Amyloid
Dementia
Parietal Lobe
Sleep
47 Citations (Scopus)

Association of hypometabolism and amyloid levels in aging, normal subjects

Lowe, V., Weigand, S. D., Senjem, M. L., Vemuri, P. D., Jordan, L., Kantarci, K. M., Boeve, B. F., Jack, C. R. J., Knopman, D. S. & Petersen, R. C., Jun 3 2014, In : Neurology. 82, 22, p. 1959-1967 9 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Fluorodeoxyglucose F18
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
Pittsburgh
8 Citations (Scopus)

Association of kidney function biomarkers with brain MRI findings: The BRINK study

Vemuri, P. D., Knopman, D. S., Jack, C. R. J., Lundt, E. S., Weigand, S. D., Zuk, S. M., Thostenson, K. B., Reid, R. I., Kantarci, K. M., Slinin, Y., Lakshminarayan, K., Davey, C. S. & Murray, A., 2017, In : Journal of Alzheimer's Disease. 55, 3, p. 1069-1082 14 p.

Research output: Contribution to journalArticle

Kidney Diseases
Glomerular Filtration Rate
Biomarkers
Chronic Renal Insufficiency
Kidney
72 Citations (Scopus)

Association of lifetime intellectual enrichment with cognitive decline in the older population

Vemuri, P. D., Lesnick, T. G., Przybelski, S. A., Machulda, M. M., Knopman, D. S., Mielke, M. M., Roberts, R. O., Geda, Y. E., Rocca, W. A., Petersen, R. C. & Jack, C. R. J., 2014, In : JAMA Neurology. 71, 8, p. 1017-1024 8 p.

Research output: Contribution to journalArticle

Occupations
Education
Population
Cognition
Dementia
131 Citations (Scopus)

Association of plasma neurofilament light with neurodegeneration in patients with Alzheimer disease

Alzheimer's Disease Neuroimaging Initiative, May 1 2017, In : JAMA Neurology. 74, 5, p. 557-566 10 p.

Research output: Contribution to journalArticle

Intermediate Filaments
Alzheimer Disease
Light
Biomarkers
Cerebrospinal Fluid
3 Citations (Scopus)
Amyloid
Dementia
Biomarkers
Positron-Emission Tomography
National Institute on Aging (U.S.)
22 Citations (Scopus)

Atrial fibrillation, cognitive impairment, and neuroimaging

Graff-Radford, J., Madhavan, M., Vemuri, P. D., Rabinstein, A., Cha, R. H., Mielke, M. M., Kantarci, K. M., Lowe, V., Senjem, M. L., Gunter, J. L., Knopman, D. S., Petersen, R. C., Jack, C. R. J. & Roberts, R. O., 2015, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Neuroimaging
Atrial Fibrillation
Infarction
Cerebrovascular Disorders
Cognitive Dysfunction
13 Citations (Scopus)

Automatic detection of three-dimensional vascular tree centerlines and bifurcations in high-resolution magnetic resonance angiography

Zhang, L., Chapman, B. E., Parker, D. L., Roberts, J. A., Guo, J., Vemuri, P. D., Moon, S. M. & Noo, F., Oct 2005, In : Investigative Radiology. 40, 10, p. 661-671 11 p.

Research output: Contribution to journalArticle

Magnetic Resonance Angiography
Blood Vessels
Costs and Cost Analysis
Skeleton
327 Citations (Scopus)

Brain beta-amyloid measures and magnetic resonance imaging atrophy both predict time-to-progression from mild cognitive impairment to Alzheimer's disease

Jack, C. R. J., Wiste, H. J., Vemuri, P. D., Weigand, S. D., Senjem, M. L., Zeng, G., Bernstein, M. A., Gunter, J. L., Pankratz, V. S., Aisen, P. S., Weiner, M. W., Petersen, R. C., Shaw, L. M., Trojanowski, J. Q. & Knopman, D. S., Nov 2010, In : Brain. 133, 11, p. 3336-3348 13 p.

Research output: Contribution to journalArticle

Amyloid
Atrophy
Alzheimer Disease
Magnetic Resonance Imaging
Brain
115 Citations (Scopus)

Brain injury biomarkers are not dependent on β-amyloid in normal elderly

Knopman, D. S., Jack, C. R. J., Wiste, H. J., Weigand, S. D., Vemuri, P. D., Lowe, V., Kantarci, K. M., Gunter, J. L., Senjem, M. L., Mielke, M. M., Roberts, R. O., Boeve, B. F. & Petersen, R. C., Apr 2013, In : Annals of Neurology. 73, 4, p. 472-480 9 p.

Research output: Contribution to journalArticle

Amyloid
Brain Injuries
Biomarkers
Positron-Emission Tomography
Alzheimer Disease
174 Citations (Scopus)

Brain β-amyloid load approaches a plateau

Jack, C. R. J., Wiste, H. J., Lesnick, T. G., Weigand, S. D., Knopman, D. S., Vemuri, P. D., Pankratz, V. S., Senjem, M. L., Gunter, J. L., Mielke, M. M., Lowe, V., Boeve, B. F. & Petersen, R. C., Mar 5 2013, In : Neurology. 80, 10, p. 890-896 7 p.

Research output: Contribution to journalArticle

Amyloid
Brain
Plateau
Alzheimer Disease
Sigmoid Colon
125 Citations (Scopus)

Cascading network failure across the Alzheimer's disease spectrum

Jones, D. T., Knopman, D. S., Gunter, J. L., Graff-Radford, J., Vemuri, P. D., Boeve, B. F., Petersen, R. C., Weiner, M. W. & Jack, C. R. J., Dec 21 2015, In : Brain. 139, 2, p. 547-562 16 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Neuroimaging
Amyloid Plaques
Brain
Frontal Lobe
16 Citations (Scopus)

Cerebral Amyloid Deposition Is Associated with Gait Parameters in the Mayo Clinic Study of Aging

Wennberg, A. M. V., Savica, R., Hagen, C. E., Roberts, R. O., Knopman, D. S., Hollman, J. H., Vemuri, P. D., Jack, C. R. J., Petersen, R. C. & Mielke, M. M., 2016, (Accepted/In press) In : Journal of the American Geriatrics Society.

Research output: Contribution to journalArticle

Gait
Amyloid
Gyrus Cinguli
Linear Models
Normal Pressure Hydrocephalus
3 Citations (Scopus)

Cerebral microbleeds: Prevalence and relationship to amyloid burden

Graff-Radford, J., Botha, H., Rabinstein, A., Gunter, J. L., Przybelski, S. A., Lesnick, T., Huston, J., Flemming, K., Preboske, G. M., Senjem, M. L., Brown, R. D. J., Mielke, M. M., Roberts, R. O., Lowe, V., Knopman, D. S., Petersen, R. C., Kremers, W. K., Vemuri, P. D., Jack, C. R. J. & Kantarci, K. M., Jan 15 2019, In : Neurology. 92, 3, p. e253-e262

Research output: Contribution to journalArticle

Amyloid
Parietal Lobe
Logistic Models
Population
Hypertension
1 Citation (Scopus)

Characteristic patterns of inter- and intra-hemispheric metabolic connectivity in patients with stable and progressive mild cognitive impairment and Alzheimer’s disease

For the Alzheimer’s Disease Neuroimaging Initiative, Dec 1 2018, In : Scientific Reports. 8, 1, 13807.

Research output: Contribution to journalArticle

Alzheimer Disease
Metabolic Networks and Pathways
Brain
Fluorodeoxyglucose F18
Occipital Lobe
17 Citations (Scopus)
Chromosomes, Human, Pair 9
Amyotrophic Lateral Sclerosis
Open Reading Frames
Neuroimaging
Parkinsonian Disorders
226 Citations (Scopus)
Parkinsonian Disorders
Age of Onset
Frontotemporal Dementia
Chromosomes, Human, Pair 9
Neuroimaging
271 Citations (Scopus)

Clinical epidemiology of Alzheimer's disease: Assessing sex and gender differences

Mielke, M. M., Vemuri, P. D. & Rocca, W. A., Jan 8 2014, In : Clinical Epidemiology. 6, 1, p. 37-48 12 p.

Research output: Contribution to journalArticle

Sex Characteristics
Alzheimer Disease
Epidemiology
Occupations
Dementia
52 Citations (Scopus)
Tauopathies
Pick Disease of the Brain
Microtubules
Progressive Supranuclear Palsy
Dementia
7 Citations (Scopus)

Cognitive interventions in Alzheimerʼs and Parkinsonʼs diseases: emerging mechanisms and role of imaging

Vemuri, P. D., Fields, J. A., Peter, J. & Klöppel, S., May 20 2016, (Accepted/In press) In : Current Opinion in Neurology.

Research output: Contribution to journalArticle

Parkinson Disease
Alzheimer Disease
Licensure
Cognition
Biomarkers
12 Citations (Scopus)

Cognitively stimulating activities to keep dementia at bay

Vemuri, P. D. & Mormino, E. C., Jul 23 2013, In : Neurology. 81, 4, p. 308-309 2 p.

Research output: Contribution to journalArticle

Dementia
81 Citations (Scopus)

Cognitive reserve and Alzheimer's disease biomarkers are independent determinants of cognition

Vemuri, P. D., Weigand, S. D., Przybelski, S. A., Knopman, D. S., Smith, G. E., Trojanowski, J. Q., Shaw, L. M., Decarli, C. S., Carmichael, O., Bernstein, M. A., Aisen, P. S., Weiner, M., Petersen, R. C. & Jack, C. R. J., May 2011, In : Brain. 134, 5, p. 1479-1492 14 p.

Research output: Contribution to journalArticle

Cognitive Reserve
Cognition
Alzheimer Disease
Biomarkers
Reading
29 Citations (Scopus)
Signal-To-Noise Ratio
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
1 Citation (Scopus)

Considerations for performing level-2 centiloid transformations for amyloid PET SUVR values

Schwarz, C., Tosakulwong, N., Senjem, M. L., Gunter, J. L., Therneau, T. M., Vemuri, P. D., Lowe, V. & Jack, C. R. J., Dec 1 2018, In : Scientific Reports. 8, 1, 7421.

Research output: Contribution to journalArticle

Linear regression
Amyloid
9 Citations (Scopus)
Amyloid
Positron-Emission Tomography
Alzheimer Disease
Research Design
2 Citations (Scopus)

Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging

Krell-Roesch, J., Vassilaki, M., Mielke, M. M., Kremers, W. K., Lowe, V., Vemuri, P. D., Machulda, M. M., Christianson, T. J., Syrjanen, J. A., Stokin, G. B., Butler, L. M., Traber, M., Jack, C. R. J., Knopman, D. S., Roberts, R. O., Petersen, R. C. & Geda, Y. E., Dec 1 2019, In : Translational psychiatry. 9, 1, 123.

Research output: Contribution to journalArticle

Open Access
Neurobehavioral Manifestations
Amyloid
Equipment and Supplies
Anxiety
Cognitive Dysfunction

Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults

Lowe, V., Bruinsma, T. J., Wiste, H. J., Min, H. K., Weigand, S. D., Fang, P., Senjem, M. L., Therneau, T. M., Boeve, B. F., Josephs, K. A., Pandey, M., Murray, M. E., Kantarci, K. M., Jones, D. T., Vemuri, P. D., Graff-Radford, J., Schwarz, C., Machulda, M. M., Mielke, M. M., Roberts, R. O. & 3 others, Knopman, D. S., Petersen, R. C. & Jack, C. R. J., Jul 2 2019, In : Neurology. 93, 1, p. e29-e39

Research output: Contribution to journalArticle

Entorhinal Cortex
Temporal Lobe
Cognition
Amyloid
Brain