Petras P Dzeja, PhD

  • 6373 Citations
  • 40 Scopus h-Index
1980 …2020

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2019

Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity

Kazak, L., Rahbani, J. F., Samborska, B., Lu, G. Z., Jedrychowski, M. P., Lajoie, M., Zhang, S., Ramsay, L. A., Dou, F. Y., Tenen, D., Chouchani, E. T., Dzeja, P., Watson, I. R., Tsai, L., Rosen, E. D. & Spiegelman, B. M., Mar 1 2019, In : Nature Metabolism. 1, 3, p. 360-370 11 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations
2018

First and second trimester urinary metabolic profiles and fetal growth restriction: An exploratory nested case-control study within the infant development and environment study

Luthra, G., Vuckovic, I., Bangdiwala, A., Gray, H., Redmon, J. B., Barrett, E. S., Sathyanarayana, S., Nguyen, R. H. N., Swan, S. H., Zhang, S., Dzeja, P., Macura, S. I. & Nair, K. S., Feb 8 2018, In : BMC Pregnancy and Childbirth. 18, 1, 48.

Research output: Contribution to journalArticle

4 Scopus citations

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation

Wang, F., Zhang, S., Vuckovic, I., Jeon, R., Lerman, A., Folmes, C., Dzeja, P. P. & Herrmann, J., Sep 4 2018, In : Cell Metabolism. 28, 3, p. 463-475.e4

Research output: Contribution to journalArticle

35 Scopus citations

Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity

Wang, F., Zhang, S., Jeon, R., Vuckovic, I., Jiang, X., Lerman, A., Folmes, C., Dzeja, P. P. & Herrmann, J., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

25 Scopus citations

Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers

Mondal, S., Roy, D., Sarkar Bhattacharya, S., Jin, L., Jung, D., Zhang, S., Kalogera, E., Staub, J., Wang, Y., Xuyang, W., Khurana, A., Chien, J., Telang, S., Chesney, J., Tapolsky, G., Dzeja, P. P. & Shridhar, V., Jan 1 2018, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

12 Scopus citations
2017

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity

Kazak, L., Chouchani, E. T., Lu, G. Z., Jedrychowski, M. P., Bare, C. J., Mina, A. I., Kumari, M., Zhang, S., Vuckovic, I., Laznik-Bogoslavski, D., Dzeja, P. P., Banks, A. S., Rosen, E. D. & Spiegelman, B. M., 2017, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

58 Scopus citations
2015

<sup>18</sup>O-assisted <sup>31</sup>P NMR and mass spectrometry for phosphometabolomic fingerprinting and metabolic monitoring

Nemutlu, E., Zhang, S., Terzic, A. & Dzeja, P. P., 2015, In : Issues in Toxicology. 2015-January, 21, p. 255-286 32 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cardiac resynchronization therapy induces adaptive metabolic transitions in the metabolomic profile of heart failure

Nemutlu, E., Zhang, S., Xu, Y. Z., Terzic, A., Zhong, L., Dzeja, P. P. & Cha, Y-M., Jun 1 2015, In : Journal of Cardiac Failure. 21, 6, p. 460-469 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Decline of phosphotransfer and substrate supply metabolic circuits hinders ATP cycling in aging myocardium

Nemutlu, E., Gupta, A., Zhang, S., Viqar, M., Holmuhamedov, E., Terzic, A., Jahangir, A. & Dzeja, P., Sep 17 2015, In : PloS one. 10, 9, e0136556.

Research output: Contribution to journalArticle

5 Scopus citations

Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation

Guzun, R., Kaambre, T., Bagur, R., Grichine, A., Usson, Y., Varikmaa, M., Anmann, T., Tepp, K., Timohhina, N., Shevchuk, I., Chekulayev, V., Boucher, F., Dos Santos, P., Schlattner, U., Wallimann, T., Kuznetsov, A. V., Dzeja, P. P., Aliev, M. & Saks, V., Jan 1 2015, In : Acta Physiologica. 213, 1, p. 84-106 23 p.

Research output: Contribution to journalArticle

31 Scopus citations

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

Zhang, L., Zhang, S., Maezawa, I., Trushin, S., Minhas, P., Pinto, M., Jin, L. W., Prasain, K., Nguyen, T. D. T., Yamazaki, Y., Kanekiyo, T., Bu, G. D., Gateno, B., Chang, K. O., Nath, K. A., Nemutlu, E., Dzeja, P. P., Pang, Y-P., Hua, D. H. & Trushina, E. D., Apr 1 2015, In : EBioMedicine. 2, 4, p. 294-305 12 p.

Research output: Contribution to journalArticle

25 Scopus citations
2014

A pharmaco-metabonomic study on chronic kidney disease and therapeutic effect of Ergone by UPLC-QTOF/HDMS

Zhao, Y. Y., Chen, H., Tian, T., Chen, D. Q., Bai, X., Wei, F. & Dzeja, P., Dec 23 2014, In : PloS one. 9, 12, e115467.

Research output: Contribution to journalArticle

52 Scopus citations
2012

Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial alzheimer's disease

Trushina, E., Nemutlu, E., Zhang, S., Christensen, T., Camp, J., Mesa, J., Siddiqui, A., Tamura, Y., Sesaki, H., Wengenack, T. M., Dzeja, P. P. & Poduslo, J. F., Feb 29 2012, In : PloS one. 7, 2, e32737.

Research output: Contribution to journalArticle

151 Scopus citations

Dynamic phosphometabolomic profiling of human tissues and transgenic models by 18O-assisted 31P NMR and mass spectrometry

Nemutlu, E., Zhang, S., Gupta, A., Juranic, N. O., Macura, S. I., Terzic, A., Jahangir, A. & Dzeja, P., Apr 1 2012, In : Physiological Genomics. 44, 7, p. 386-402 17 p.

Research output: Contribution to journalArticle

15 Scopus citations

Electron spray ionization mass spectrometry and 2D 31P NMR for monitoring 18O/16O isotope exchange and turnover rates of metabolic oligophosphates

Nemutlu, E., Juranic, N., Zhang, S., Ward, L. E., Dutta, T., Sreekumaran Nair, K., Terzic, A., Macura, S. & Dzeja, P. P., May 1 2012, In : Analytical and bioanalytical chemistry. 403, 3, p. 697-706 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Energy metabolism plasticity enables stemness programs

Folmes, C. D. L., Nelson, T. J., Dzeja, P. P. & Terzic, A., Apr 2012, In : Annals of the New York Academy of Sciences. 1254, 1, p. 82-89 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

Mitochondria in control of cell fate

Folmes, C. D. L., Dzeja, P. P., Nelson, T. J. & Terzic, A., Feb 17 2012, In : Circulation research. 110, 4, p. 526-529 4 p.

Research output: Contribution to journalArticle

49 Scopus citations
2011

31P NMR correlation maps of 18O/16O chemical shift isotopic effects for phosphometabolite labeling studies

Juranić, N., Nemutlu, E., Zhang, S., Dzeja, P., Terzic, A. & MacUra, S., Jul 1 2011, In : Journal of Biomolecular NMR. 50, 3, p. 237-245 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Developmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation

Dzeja, P. P., Chung, S., Faustino, R. S., Behfar, A. & Terzic, A., 2011, In : PloS one. 6, 4, e19300.

Research output: Contribution to journalArticle

39 Scopus citations

Rearrangement of energetic and substrate utilization networks compensate for chronic myocardial creatine kinase deficiency

Dzeja, P. P., Hoyer, K., Tian, R., Zhang, S., Nemutlu, E., Spindler, M. & Ingwall, J. S., Nov 1 2011, In : Journal of Physiology. 589, 21, p. 5193-5211 19 p.

Research output: Contribution to journalArticle

38 Scopus citations

Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming

Folmes, C. D. L., Nelson, T. J., Martinez-Fernandez, A., Arrell, D. K., Lindor, J. Z., Dzeja, P. P., Ikeda, Y., Perez-Terzic, C. & Terzic, A., Aug 3 2011, In : Cell Metabolism. 14, 2, p. 264-271 8 p.

Research output: Contribution to journalArticle

534 Scopus citations

Unique cellular and mitochondrial defects mediate FK506-induced islet β-cell dysfunction

Rostambeigi, N., Lanza, I. R., Dzeja, P. P., Deeds, M. C., Irving, B. A., Reddi, H. V., Madde, P., Zhang, S., Asmann, Y. W., Anderson, J. M., Schimke, J. M., Nair, K. S., Eberhardt, N. L. & Kudva, Y. C., Mar 27 2011, In : Transplantation. 91, 6, p. 615-623 9 p.

Research output: Contribution to journalArticle

35 Scopus citations
2010

Glycolytic network restructuring integral to the energetics of embryonic stem cell cardiac differentiation

Chung, S., Arrell, D. K., Faustino, R. S., Terzic, A. & Dzeja, P. P., Apr 1 2010, In : Journal of Molecular and Cellular Cardiology. 48, 4, p. 725-734 10 p.

Research output: Contribution to journalArticle

97 Scopus citations

Metabolic assessment of a novel chronic myelogenous leukemic cell line and an imatinib resistant subline by 1H NMR spectroscopy

Dewar, B. J., Keshari, K., Jeffries, R., Dzeja, P., Graves, L. M. & Macdonald, J. M., Mar 22 2010, In : Metabolomics. 6, 3, p. 439-450 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
2008

Doppler Strain Imaging Closely Reflects Myocardial Energetic Status in Acute Progressive Ischemia and Indicates Energetic Recovery After Reperfusion

Korinek, J., Sengupta, P. P., Wang, J., Romero-Corral, A., Boukatina, A. E., Vitek, J., Krishnamoorthy, V. K., Cha, S. S., Dzeja, P. P., Terzic, A., Khandheria, B. K. & Belohlavek, M., Aug 1 2008, In : Journal of the American Society of Echocardiography. 21, 8, p. 961-968 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
2007

Defective metabolic signaling in adenylate kinase AK1 gene knock-out hearts compromises post-ischemic coronary reflow

Dzeja, P. P., Bast, P., Pucar, D., Wieringa, B. & Terzic, A., Oct 26 2007, In : Journal of Biological Chemistry. 282, 43, p. 31366-31372 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells

Chung, S., Dzeja, P. P., Faustino, R. S., Perez-Terzic, C., Behfar, A. & Terzic, A., Feb 1 2007, In : Nature Clinical Practice Cardiovascular Medicine. 4, SUPPL. 1, p. S60-S67

Research output: Contribution to journalArticle

306 Scopus citations
2006
16 Scopus citations
2004

ATP-sensitive K+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits

Kane, G. C., Behfar, A., Yamada, S., Perez-Terzic, C., O'Cochlain, F., Reyes, S., Dzeja, P. P., Miki, T., Seino, S. & Terzic, A., Dec 1 2004, In : Diabetes. 53, SUPPL. 3, p. S169-S175

Research output: Contribution to journalArticle

88 Scopus citations
12 Scopus citations
84 Scopus citations
2003

Adenylate kinase 1 deficiency induces molecular and structural adaptations to support muscle energy metabolism

Janssen, E., De Groof, A., Wijers, M., Fransen, J., Dzeja, P. P., Terzic, A. & Wieringa, B., Apr 11 2003, In : Journal of Biological Chemistry. 278, 15, p. 12937-12945 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Failing atrial myocardium: Energetic deficits accompany structural remodeling and electrical instability

Cha, Y. M., Dzeja, P. P., Shen, W. K., Jahangir, A., Hart, C. Y. T., Terzic, A. & Redfield, M. M., Apr 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 4 53-4, p. H1313-H1320

Research output: Contribution to journalArticle

84 Scopus citations

Impaired intracellular energetic communication in muscles from creatine kinase and adenylate kinase (M-CK/AK1) double knock-out mice

Janssen, E., Terzic, A., Wieringa, B. & Dzeja, P. P., Aug 15 2003, In : Journal of Biological Chemistry. 278, 33, p. 30441-30449 9 p.

Research output: Contribution to journalArticle

52 Scopus citations

Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics

Gumina, R. J., Pucar, D., Bast, P., Hodgson, D. M., Kurtz, C. E., Dzeja, P. P., Miki, T., Seino, S. & Terzic, A., Jun 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 6 53-6, p. H2106-H2113

Research output: Contribution to journalArticle

119 Scopus citations

Targeting nucleotide-requiring enzymes: Implications for diazoxide-induced cardioprotection

Dzeja, P. P., Bast, P., Ozcan, C., Valverde, A., Holmuhamedov, E. L., Van Wylen, D. G. L. & Terzic, A., Apr 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 4 53-4, p. H1048-H1056

Research output: Contribution to journalArticle

88 Scopus citations
2002

Adenylate kinase AK1 knockout heart: Energetics and functional performance under ischemia-reperfusion

Pucar, D., Bast, P., Gumina, R. J., Lim, L., Drahl, C., Juranic, N., Macura, S., Janssen, E., Wieringa, B., Terzic, A. & Dzeja, P. P., Jul 30 2002, In : American Journal of Physiology - Heart and Circulatory Physiology. 283, 2 52-2, p. H776-H782

Research output: Contribution to journalArticle

49 Scopus citations

Coupling of cell energetics with membrane metabolic sensing: Integrative signaling through creatine kinase phosphotransfer disrupted by M-CK gene knock-out

Roselle Abraham, M., Selivanov, V. A., Hodgson, D. M., Pucar, D., Zingman, L. V., Wieringa, B., Dzeja, P. P., Alekseev, A. E. & Terzic, A., Jul 5 2002, In : Journal of Biological Chemistry. 277, 27, p. 24427-24434 8 p.

Research output: Contribution to journalArticle

126 Scopus citations
118 Scopus citations

Kir6.2 is required for adaptation to stress

Zingman, L. V., Hodgson, D. M., Bast, P. H., Kane, G. C., Perez-Terzic, C., Gumina, R. J., Pucar, D., Bienengraeber, M., Dzeja, P. P., Miki, T., Seino, S., Alekseev, A. E. & Terzic, A., Oct 1 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 20, p. 13278-13283 6 p.

Research output: Contribution to journalArticle

248 Scopus citations

Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation

Ozcan, C., Bienengraeber, M., Dzeja, P. P. & Terzic, A., Jun 29 2002, In : American Journal of Physiology - Heart and Circulatory Physiology. 282, 2 51-2, p. H531-H539

Research output: Contribution to journalArticle

189 Scopus citations
2001

Adenylate kinase phosphotransfer communicates cellular energetic signals to ATP-sensitive potassium channels

Carrasco, A. J., Dzeja, P. P., Alekseev, A. E., Pucar, D., Zingman, L. V., Abraham, M. R., Hodgson, D., Bienengraeber, M., Puceat, M., Janssen, E., Wieringa, B. & Terzic, A., Jun 19 2001, In : Proceedings of the National Academy of Sciences of the United States of America. 98, 13, p. 7623-7628 6 p.

Research output: Contribution to journalArticle

202 Scopus citations

ATPase of the sulfonylurea receptor and KATP channel gating

Zingman, L. V., Alekseev, A. E., Bienengraeber, M., Dzeja, P. P. & Terzic, A., Dec 1 2001, In : Clinical pharmacology and therapeutics. 69, 2, p. P62

Research output: Contribution to journalArticle

Cellular energetics in the preconditioned state: Protective role for phosphotransfer reactions captured by 18O-assisted 31P NMR

Pucar, D., Dzeja, P. P., Bast, P., Juranic, N., Macura, S. & Terzic, A., Nov 30 2001, In : Journal of Biological Chemistry. 276, 48, p. 44812-44819 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

Directed Inhibition of Nuclear Import in Cellular Hypertrophy

Perez-Terzic, C., Gacy, A. M., Bortolon, R., Dzeja, P. P., Puceat, M., Jaconi, M., Prendergast, F. G. & Terzic, A., Jun 8 2001, In : Journal of Biological Chemistry. 276, 23, p. 20566-20571 6 p.

Research output: Contribution to journalArticle

28 Scopus citations

Signaling in channel/enzyme multimers: ATPase transitions in SUR module gate ATP-sensitive K+ conductance

Zingman, L. V., Alekseev, A. E., Bienengraeber, M., Hodgson, D., Karger, A. B., Dzeja, P. P. & Terzic, A., Aug 2 2001, In : Neuron. 31, 2, p. 233-245 13 p.

Research output: Contribution to journalArticle

166 Scopus citations
2000

Adenylate kinase 1 gene deletion disrupts muscle energetic economy despite metabolic rearrangement

Janssen, E., Dzeja, P. P., Oerlemans, F., Simonetti, A. W., Heerschap, A., De Haan, A., Rush, P. S., Terjung, R. R., Wieringa, B. & Terzic, A., Dec 1 2000, In : EMBO Journal. 19, 23, p. 6371-6381 11 p.

Research output: Contribution to journalArticle

113 Scopus citations

ATPase activity of the sulfonylurea receptor: A catalytic function for the K(ATP) channel complex

Bienengraeber, M., Alekseev, A. E., Abraham, M. R., Carrasco, A. J., Moreau, C., Vivaudou, M., Dzeja, P. P. & Terzic, A., Oct 16 2000, In : FASEB Journal. 14, 13, p. 1943-1952 10 p.

Research output: Contribution to journalArticle

124 Scopus citations

Compromised energetics in the adenylate kinase AK1 gene knockout heart under metabolic stress

Pucar, D., Janssen, E., Dzeja, P. P., Juranic, N., Macura, S., Wieringa, B. & Terzic, A., Dec 29 2000, In : Journal of Biological Chemistry. 275, 52, p. 41424-41429 6 p.

Research output: Contribution to journalArticle

69 Scopus citations

Failing energetics in failing hearts

Dzeja, P. P., Redfield, M. M., Burnett, J. C. & Terzic, A., Dec 1 2000, In : Current cardiology reports. 2, 3, p. 212-217 6 p.

Research output: Contribution to journalArticle

86 Scopus citations