Petras P Dzeja, PhD

  • 6237 Citations
  • 40 Scopus h-Index
1980 …2019

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2019

Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity

Kazak, L., Rahbani, J. F., Samborska, B., Lu, G. Z., Jedrychowski, M. P., Lajoie, M., Zhang, S., Ramsay, L. A., Dou, F. Y., Tenen, D., Chouchani, E. T., Dzeja, P., Watson, I. R., Tsai, L., Rosen, E. D. & Spiegelman, B. M., Mar 1 2019, In : Nature Metabolism. 1, 3, p. 360-370 11 p.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
2018

First and second trimester urinary metabolic profiles and fetal growth restriction: An exploratory nested case-control study within the infant development and environment study

Luthra, G., Vuckovic, I., Bangdiwala, A., Gray, H., Redmon, J. B., Barrett, E. S., Sathyanarayana, S., Nguyen, R. H. N., Swan, S. H., Zhang, S., Dzeja, P. P., Macura, S. I. & Nair, K. S., Feb 8 2018, In : BMC Pregnancy and Childbirth. 18, 1, 48.

Research output: Contribution to journalArticle

3 Scopus citations

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation

Wang, F., Zhang, S., Vuckovic, I., Jeon, R., Lerman, A., Folmes, C., Dzeja, P. P. & Herrmann, J., Sep 4 2018, In : Cell Metabolism. 28, 3, p. 463-475.e4

Research output: Contribution to journalArticle

28 Scopus citations

Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity

Wang, F., Zhang, S., Jeon, R., Vuckovic, I., Jiang, X., Lerman, A., Folmes, C., Dzeja, P. P. & Herrmann, J., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

22 Scopus citations

Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers

Mondal, S., Roy, D., Sarkar Bhattacharya, S., Jin, L., Jung, D., Zhang, S., Kalogera, E., Staub, J., Wang, Y., Xuyang, W., Khurana, A., Chien, J., Telang, S., Chesney, J., Tapolsky, G., Dzeja, P. P. & Shridhar, V., Jan 1 2018, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

12 Scopus citations
2017

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity

Kazak, L., Chouchani, E. T., Lu, G. Z., Jedrychowski, M. P., Bare, C. J., Mina, A. I., Kumari, M., Zhang, S., Vuckovic, I., Laznik-Bogoslavski, D., Dzeja, P. P., Banks, A. S., Rosen, E. D. & Spiegelman, B. M., 2017, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

51 Scopus citations
2015

<sup>18</sup>O-assisted <sup>31</sup>P NMR and mass spectrometry for phosphometabolomic fingerprinting and metabolic monitoring

Nemutlu, E., Zhang, S., Terzic, A. & Dzeja, P. P., 2015, In : Issues in Toxicology. 2015-January, 21, p. 255-286 32 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cardiac resynchronization therapy induces adaptive metabolic transitions in the metabolomic profile of heart failure

Nemutlu, E., Zhang, S., Xu, Y. Z., Terzic, A., Zhong, L., Dzeja, P. P. & Cha, Y-M., Jun 1 2015, In : Journal of Cardiac Failure. 21, 6, p. 460-469 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Decline of phosphotransfer and substrate supply metabolic circuits hinders ATP cycling in aging myocardium

Nemutlu, E., Gupta, A., Zhang, S., Viqar, M., Holmuhamedov, E., Terzic, A., Jahangir, A. & Dzeja, P. P., Sep 17 2015, In : PLoS One. 10, 9, e0136556.

Research output: Contribution to journalArticle

5 Scopus citations

Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation

Guzun, R., Kaambre, T., Bagur, R., Grichine, A., Usson, Y., Varikmaa, M., Anmann, T., Tepp, K., Timohhina, N., Shevchuk, I., Chekulayev, V., Boucher, F., Dos Santos, P., Schlattner, U., Wallimann, T., Kuznetsov, A. V., Dzeja, P. P., Aliev, M. & Saks, V., Jan 1 2015, In : Acta Physiologica. 213, 1, p. 84-106 23 p.

Research output: Contribution to journalArticle

29 Scopus citations

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

Zhang, L., Zhang, S., Maezawa, I., Trushin, S., Minhas, P., Pinto, M., Jin, L. W., Prasain, K., Nguyen, T. D. T., Yamazaki, Y., Kanekiyo, T., Bu, G. D., Gateno, B., Chang, K. O., Nath, K. A., Nemutlu, E., Dzeja, P. P., Pang, Y-P., Hua, D. H. & Trushina, E. D., Apr 1 2015, In : EBioMedicine. 2, 4, p. 294-305 12 p.

Research output: Contribution to journalArticle

24 Scopus citations
2014

A pharmaco-metabonomic study on chronic kidney disease and therapeutic effect of Ergone by UPLC-QTOF/HDMS

Zhao, Y. Y., Chen, H., Tian, T., Chen, D. Q., Bai, X., Wei, F. & Dzeja, P. P., Dec 23 2014, In : PLoS One. 9, 12, e115467.

Research output: Contribution to journalArticle

49 Scopus citations
2012

18O-assisted dynamic metabolomics for individualized diagnostics and treatment of human diseases

Nemutlu, E., Zhang, S., Juranic, N. O., Terzic, A., Macura, S. I. & Dzeja, P. P., 2012, In : Croatian Medical Journal. 53, 6, p. 529-534 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Compartmentation of membrane processes and nucleotide dynamics in diffusion-restricted cardiac cell microenvironment

Alekseev, A. E., Reyes, S., Selivanov, V. A., Dzeja, P. P. & Terzic, A., Feb 2012, In : Journal of Molecular and Cellular Cardiology. 52, 2, p. 401-409 9 p.

Research output: Contribution to journalArticle

33 Scopus citations

Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial alzheimer's disease

Trushina, E. D., Nemutlu, E., Zhang, S., Christensen, T., Camp, J., Mesa, J., Siddiqui, A., Tamura, Y., Sesaki, H., Wengenack, T. M., Dzeja, P. P. & Poduslo, J. F., Feb 29 2012, In : PLoS One. 7, 2, e32737.

Research output: Contribution to journalArticle

149 Scopus citations

Dynamic phosphometabolomic profiling of human tissues and transgenic models by 18O-assisted 31P NMR and mass spectrometry

Nemutlu, E., Zhang, S., Gupta, A., Juranic, N. O., Macura, S. I., Terzic, A., Jahangir, A. & Dzeja, P. P., Apr 1 2012, In : Physiological Genomics. 44, 7, p. 386-402 17 p.

Research output: Contribution to journalArticle

15 Scopus citations

Electron spray ionization mass spectrometry and 2D 31P NMR for monitoring 18O/16O isotope exchange and turnover rates of metabolic oligophosphates

Nemutlu, E., Juranic, N., Zhang, S., Ward, L. E., Dutta, T., Nair, K. S., Terzic, A., Macura, S. I. & Dzeja, P. P., May 2012, In : Analytical and Bioanalytical Chemistry. 403, 3, p. 697-706 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Energy metabolism plasticity enables stemness programs

Folmes, C., Nelson, T. J., Dzeja, P. P. & Terzic, A., Apr 2012, In : Annals of the New York Academy of Sciences. 1254, 1, p. 82-89 8 p.

Research output: Contribution to journalArticle

63 Scopus citations

Metabolic plasticity in stem cell homeostasis and differentiation

Folmes, C., Dzeja, P. P., Nelson, T. J. & Terzic, A., Nov 2 2012, In : Cell Stem Cell. 11, 5, p. 596-606 11 p.

Research output: Contribution to journalArticle

318 Scopus citations

Mitochondria in control of cell fate

Folmes, C., Dzeja, P. P., Nelson, T. J. & Terzic, A., Feb 17 2012, In : Circulation Research. 110, 4, p. 526-529 4 p.

Research output: Contribution to journalArticle

48 Scopus citations
2011

31P NMR correlation maps of 18O/16O chemical shift isotopic effects for phosphometabolite labeling studies

Juranić, N., Nemutlu, E., Zhang, S., Dzeja, P. P., Terzic, A. & Macura, S. I., Jul 2011, In : Journal of Biomolecular NMR. 50, 3, p. 237-245 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Developmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation

Dzeja, P. P., Chung, S., Faustino, R. S., Behfar, A. & Terzic, A., 2011, In : PLoS One. 6, 4, e19300.

Research output: Contribution to journalArticle

36 Scopus citations

Rearrangement of energetic and substrate utilization networks compensate for chronic myocardial creatine kinase deficiency

Dzeja, P. P., Hoyer, K., Tian, R., Zhang, S., Nemutlu, E., Spindler, M. & Ingwall, J. S., Nov 2011, In : Journal of Physiology. 589, 21, p. 5193-5211 19 p.

Research output: Contribution to journalArticle

37 Scopus citations

Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming

Folmes, C., Nelson, T. J., Martinez-Fernandez, A., Arrell, D. K., Lindor, J. Z., Dzeja, P. P., Ikeda, Y. H., Terzic, C. M. & Terzic, A., Aug 3 2011, In : Cell Metabolism. 14, 2, p. 264-271 8 p.

Research output: Contribution to journalArticle

517 Scopus citations

Unique cellular and mitochondrial defects mediate FK506-induced islet β-cell dysfunction

Rostambeigi, N., Lanza, I. R., Dzeja, P. P., Deeds, M. C., Irving, B. A., Reddi, H. V., Madde, P., Zhang, S., Asmann, Y., Anderson, J. M., Schimke, J. M., Nair, K. S., Eberhardt, N. L. & Kudva, Y. C., Mar 27 2011, In : Transplantation. 91, 6, p. 615-623 9 p.

Research output: Contribution to journalArticle

34 Scopus citations
2010

Glycolytic network restructuring integral to the energetics of embryonic stem cell cardiac differentiation

Chung, S., Arrell, D. K., Faustino, R. S., Terzic, A. & Dzeja, P. P., Apr 2010, In : Journal of Molecular and Cellular Cardiology. 48, 4, p. 725-734 10 p.

Research output: Contribution to journalArticle

91 Scopus citations

Metabolic assessment of a novel chronic myelogenous leukemic cell line and an imatinib resistant subline by 1H NMR spectroscopy

Dewar, B. J., Keshari, K., Jeffries, R., Dzeja, P. P., Graves, L. M. & Macdonald, J. M., 2010, In : Metabolomics. 6, 3, p. 439-450 12 p.

Research output: Contribution to journalArticle

17 Scopus citations

Where have the fluxes gone?

Aliev, M., Schlattner, U., Dzeja, P. P., Wallimann, T. & Saks, V., Dec 24 2010, In : Journal of Biological Chemistry. 285, 52

Research output: Contribution to journalArticle

1 Scopus citations
2009
210 Scopus citations
2008

Doppler Strain Imaging Closely Reflects Myocardial Energetic Status in Acute Progressive Ischemia and Indicates Energetic Recovery After Reperfusion

Korinek, J., Sengupta, P. P., Wang, J., Romero-Corral, A., Boukatina, A. E., Vitek, J., Krishnamoorthy, V. K., Cha, S. S., Dzeja, P. P., Terzic, A., Khandheria, B. K. & Belohlavek, M., Aug 2008, In : Journal of the American Society of Echocardiography. 21, 8, p. 961-968 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Guided stem cell cardiopoiesis: Discovery and translation

Behfar, A., Faustino, R. S., Arrell, D. K., Dzeja, P. P., Terzic, C. M. & Terzic, A., Oct 2008, In : Journal of Molecular and Cellular Cardiology. 45, 4, p. 523-529 7 p.

Research output: Contribution to journalArticle

54 Scopus citations
2007

Defective metabolic signaling in adenylate kinase AK1 gene knock-out hearts compromises post-ischemic coronary reflow

Dzeja, P. P., Bast, P., Pucar, D., Wieringa, B. & Terzic, A., Oct 26 2007, In : Journal of Biological Chemistry. 282, 43, p. 31366-31372 7 p.

Research output: Contribution to journalArticle

29 Scopus citations
302 Scopus citations
2006
16 Scopus citations

Cardiac system bioenergetics: Metabolic basis of the frank-starling law

Saks, V., Dzeja, P. P., Schlattner, U., Vendelin, M., Terzic, A. & Wallimann, T., Mar 2006, In : Journal of Physiology. 571, 2, p. 253-273 21 p.

Research output: Contribution to journalArticle

179 Scopus citations
2004

ATP-sensitive K+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits

Kane, G. M., Behfar, A., Yamada, S., Terzic, C. M., O'Cochlain, F., Reyes, S., Dzeja, P. P., Miki, T., Seino, S. & Terzic, A., Dec 2004, In : Diabetes. 53, SUPPL. 3

Research output: Contribution to journalArticle

88 Scopus citations
12 Scopus citations

Mapping hypoxia-induced bioenergetic rearrangement and metabolic signalling by 18O-assisted 31P NMR and 1 NMR spectroscopy

Pucar, D., Dzeja, P. P., Bast, P., Gumina, R. J., Drahl, C., Lim, L., Juranic, N., Macura, S. I. & Terzic, A., Jan 2004, In : Molecular and Cellular Biochemistry. 256-257, 1-2, p. 281-289 9 p.

Research output: Contribution to journalArticle

34 Scopus citations
84 Scopus citations

Phosphotransfer dynamics in skeletal muscle from creatine kinase gene-deleted mice

Dzeja, P. P., Terzic, A. & Wieringa, B., Jan 2004, In : Molecular and Cellular Biochemistry. 256-257, 1-2, p. 13-27 15 p.

Research output: Contribution to journalArticle

53 Scopus citations
2003

Adenylate kinase 1 deficiency induces molecular and structural adaptations to support muscle energy metabolism

Janssen, E., De Groof, A., Wijers, M., Fransen, J., Dzeja, P. P., Terzic, A. & Wieringa, B., Apr 11 2003, In : Journal of Biological Chemistry. 278, 15, p. 12937-12945 9 p.

Research output: Contribution to journalArticle

35 Scopus citations
82 Scopus citations

Impaired intracellular energetic communication in muscles from creatine kinase and adenylate kinase (M-CK/AK1) double knock-out mice

Janssen, E., Terzic, A., Wieringa, B. & Dzeja, P. P., Aug 15 2003, In : Journal of Biological Chemistry. 278, 33, p. 30441-30449 9 p.

Research output: Contribution to journalArticle

51 Scopus citations

Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics

Gumina, R. J., Pucar, D., Bast, P., Hodgson, D. M., Kurtz, C. E., Dzeja, P. P., Miki, T., Seino, S. & Terzic, A., Jun 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 6 53-6

Research output: Contribution to journalArticle

118 Scopus citations

Phosphotransfer networks and cellular energetics

Dzeja, P. P. & Terzic, A., Jun 2003, In : Journal of Experimental Biology. 206, 12, p. 2039-2047 9 p.

Research output: Contribution to journalArticle

349 Scopus citations

Targeting nucleotide-requiring enzymes: Implications for diazoxide-induced cardioprotection

Dzeja, P. P., Bast, P., Ozcan, C., Valverde, A., Holmuhamedov, E. L., Van Wylen, D. G. L. & Terzic, A., Apr 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 4 53-4

Research output: Contribution to journalArticle

88 Scopus citations
2002

Adenylate kinase AK1 knockout heart: Energetics and functional performance under ischemia-reperfusion

Pucar, D., Bast, P., Gumina, R. J., Lim, L., Drahl, C., Juranic, N., Macura, S. I., Janssen, E., Wieringa, B., Terzic, A. & Dzeja, P. P., 2002, In : American Journal of Physiology - Heart and Circulatory Physiology. 283, 2 52-2

Research output: Contribution to journalArticle

48 Scopus citations

Coupling of cell energetics with membrane metabolic sensing: Integrative signaling through creatine kinase phosphotransfer disrupted by M-CK gene knock-out

Roselle Abraham, M., Selivanov, V. A., Hodgson, D. M., Pucar, D., Zingman, L. V., Wieringa, B., Dzeja, P. P., Alekseev, A. E. & Terzic, A., Jul 5 2002, In : Journal of Biological Chemistry. 277, 27, p. 24427-24434 8 p.

Research output: Contribution to journalArticle

126 Scopus citations

Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer

Dzeja, P. P., Bortolon, R., Terzic, C. M., Holmuhamedov, E. L. & Terzic, A., Jul 23 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 15, p. 10156-10161 6 p.

Research output: Contribution to journalArticle

117 Scopus citations

Kir6.2 is required for adaptation to stress

Zingman, L. V., Hodgson, D. M., Bast, P. H., Kane, G. M., Terzic, C. M., Gumina, R. J., Pucar, D., Bienengraeber, M., Dzeja, P. P., Miki, T., Seino, S., Alekseev, A. E. & Terzic, A., Oct 1 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 20, p. 13278-13283 6 p.

Research output: Contribution to journalArticle

248 Scopus citations