Petras P Dzeja, PhD

  • 6026 Citations
  • 40 Scopus h-Index
1980 …2019
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Research Output 1980 2019

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Article
2019
9 Citations (Scopus)

Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity

Kazak, L., Rahbani, J. F., Samborska, B., Lu, G. Z., Jedrychowski, M. P., Lajoie, M., Zhang, S., Ramsay, L. A., Dou, F. Y., Tenen, D., Chouchani, E. T., Dzeja, P., Watson, I. R., Tsai, L., Rosen, E. D. & Spiegelman, B. M., Mar 1 2019, In : Nature Metabolism. 1, 3, p. 360-370 11 p.

Research output: Contribution to journalArticle

Open Access
Creatine
Thermogenesis
Adipocytes
Obesity
Diet
2018
3 Citations (Scopus)

First and second trimester urinary metabolic profiles and fetal growth restriction: An exploratory nested case-control study within the infant development and environment study

Luthra, G., Vuckovic, I., Bangdiwala, A., Gray, H., Redmon, J. B., Barrett, E. S., Sathyanarayana, S., Nguyen, R. H. N., Swan, S. H., Zhang, S., Dzeja, P. P., Macura, S. I. & Nair, K. S., Feb 8 2018, In : BMC Pregnancy and Childbirth. 18, 1, 48.

Research output: Contribution to journalArticle

Metabolome
Second Pregnancy Trimester
First Pregnancy Trimester
Fetal Development
Child Development
17 Citations (Scopus)

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation

Wang, F., Zhang, S., Vuckovic, I., Jeon, R., Lerman, A., Folmes, C., Dzeja, P. P. & Herrmann, J., Sep 4 2018, In : Cell Metabolism. 28, 3, p. 463-475.e4

Research output: Contribution to journalArticle

Glycolysis
Oxidative Phosphorylation
Macrophages
Glucose
Adenosine Triphosphate
16 Citations (Scopus)

Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity

Wang, F., Zhang, S., Jeon, R., Vuckovic, I., Jiang, X., Lerman, A., Folmes, C., Dzeja, P. P. & Herrmann, J., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Macrophages
Glycolysis
Interferon-gamma
Cell Survival
Interferons
8 Citations (Scopus)

Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers

Mondal, S., Roy, D., Sarkar Bhattacharya, S., Jin, L., Jung, D., Zhang, S., Kalogera, E., Staub, J., Wang, Y., Xuyang, W., Khurana, A., Chien, J., Telang, S., Chesney, J., Tapolsky, G., Dzeja, P. P. & Shridhar, V., Jan 1 2018, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

Carboplatin
Neoplasms
Paclitaxel
Fluorescent Antibody Technique
Therapeutics
2017
46 Citations (Scopus)

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity

Kazak, L., Chouchani, E. T., Lu, G. Z., Jedrychowski, M. P., Bare, C. J., Mina, A. I., Kumari, M., Zhang, S., Vuckovic, I., Laznik-Bogoslavski, D., Dzeja, P. P., Banks, A. S., Rosen, E. D. & Spiegelman, B. M., 2017, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Creatine
Thermogenesis
Adipocytes
Obesity
Diet
2015
1 Citation (Scopus)

<sup>18</sup>O-assisted <sup>31</sup>P NMR and mass spectrometry for phosphometabolomic fingerprinting and metabolic monitoring

Nemutlu, E., Zhang, S., Terzic, A. & Dzeja, P. P., 2015, In : Issues in Toxicology. 2015-January, 21, p. 255-286 32 p.

Research output: Contribution to journalArticle

Mass spectrometry
Mass Spectrometry
Nuclear magnetic resonance
Monitoring
24 Citations (Scopus)

Cardiac resynchronization therapy induces adaptive metabolic transitions in the metabolomic profile of heart failure

Nemutlu, E., Zhang, S., Xu, Y. Z., Terzic, A., Zhong, L., Dzeja, P. P. & Cha, Y-M., Jun 1 2015, In : Journal of Cardiac Failure. 21, 6, p. 460-469 10 p.

Research output: Contribution to journalArticle

Cardiac Resynchronization Therapy
Metabolomics
Heart Failure
Citric Acid Cycle
Glutamic Acid
5 Citations (Scopus)

Decline of phosphotransfer and substrate supply metabolic circuits hinders ATP cycling in aging myocardium

Nemutlu, E., Gupta, A., Zhang, S., Viqar, M., Holmuhamedov, E., Terzic, A., Jahangir, A. & Dzeja, P. P., Sep 17 2015, In : PLoS One. 10, 9, e0136556.

Research output: Contribution to journalArticle

adenylate kinase
myocardium
creatine kinase
Myocardium
Adenosine Triphosphate
28 Citations (Scopus)

Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation

Guzun, R., Kaambre, T., Bagur, R., Grichine, A., Usson, Y., Varikmaa, M., Anmann, T., Tepp, K., Timohhina, N., Shevchuk, I., Chekulayev, V., Boucher, F., Dos Santos, P., Schlattner, U., Wallimann, T., Kuznetsov, A. V., Dzeja, P. P., Aliev, M. & Saks, V., Jan 1 2015, In : Acta Physiologica. 213, 1, p. 84-106 23 p.

Research output: Contribution to journalArticle

Energy Transfer
Energy Metabolism
Adenosine Triphosphate
Mitochondrial Membranes
Permeability
22 Citations (Scopus)

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

Zhang, L., Zhang, S., Maezawa, I., Trushin, S., Minhas, P., Pinto, M., Jin, L. W., Prasain, K., Nguyen, T. D. T., Yamazaki, Y., Kanekiyo, T., Bu, G. D., Gateno, B., Chang, K. O., Nath, K. A., Nemutlu, E., Dzeja, P. P., Pang, Y-P., Hua, D. H. & Trushina, E. D., Apr 1 2015, In : EBioMedicine. 2, 4, p. 294-305 12 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Animals
Animal Models
Modulation
Glycogen Synthase Kinase 3
2014
47 Citations (Scopus)

A pharmaco-metabonomic study on chronic kidney disease and therapeutic effect of Ergone by UPLC-QTOF/HDMS

Zhao, Y. Y., Chen, H., Tian, T., Chen, D. Q., Bai, X., Wei, F. & Dzeja, P. P., Dec 23 2014, In : PLoS One. 9, 12, e115467.

Research output: Contribution to journalArticle

Metabolomics
metabolomics
Therapeutic Uses
kidney diseases
Chronic Renal Insufficiency
2012
8 Citations (Scopus)

18O-assisted dynamic metabolomics for individualized diagnostics and treatment of human diseases

Nemutlu, E., Zhang, S., Juranic, N. O., Terzic, A., Macura, S. I. & Dzeja, P. P., 2012, In : Croatian Medical Journal. 53, 6, p. 529-534 6 p.

Research output: Contribution to journalArticle

Metabolomics
Technology
Inventions
Metabolome
Proteome
31 Citations (Scopus)

Compartmentation of membrane processes and nucleotide dynamics in diffusion-restricted cardiac cell microenvironment

Alekseev, A. E., Reyes, S., Selivanov, V. A., Dzeja, P. P. & Terzic, A., Feb 2012, In : Journal of Molecular and Cellular Cardiology. 52, 2, p. 401-409 9 p.

Research output: Contribution to journalArticle

Cellular Microenvironment
Nucleotides
Cytosol
Membranes
Ions
143 Citations (Scopus)

Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial alzheimer's disease

Trushina, E. D., Nemutlu, E., Zhang, S., Christensen, T., Camp, J., Mesa, J., Siddiqui, A., Tamura, Y., Sesaki, H., Wengenack, T. M., Dzeja, P. P. & Poduslo, J. F., Feb 29 2012, In : PLoS One. 7, 2, e32737.

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Metabolomics
metabolomics
Alzheimer disease
Alzheimer Disease
15 Citations (Scopus)

Dynamic phosphometabolomic profiling of human tissues and transgenic models by 18O-assisted 31P NMR and mass spectrometry

Nemutlu, E., Zhang, S., Gupta, A., Juranic, N. O., Macura, S. I., Terzic, A., Jahangir, A. & Dzeja, P. P., Apr 1 2012, In : Physiological Genomics. 44, 7, p. 386-402 17 p.

Research output: Contribution to journalArticle

Adenylate Kinase
Metabolomics
Mass Spectrometry
Magnetic Resonance Spectroscopy
Adenosine Triphosphate
7 Citations (Scopus)

Electron spray ionization mass spectrometry and 2D 31P NMR for monitoring 18O/16O isotope exchange and turnover rates of metabolic oligophosphates

Nemutlu, E., Juranic, N., Zhang, S., Ward, L. E., Dutta, T., Nair, K. S., Terzic, A., Macura, S. I. & Dzeja, P. P., May 2012, In : Analytical and Bioanalytical Chemistry. 403, 3, p. 697-706 10 p.

Research output: Contribution to journalArticle

Electrospray ionization
Isotopes
Electrospray Ionization Mass Spectrometry
Ionization
Mass spectrometry
61 Citations (Scopus)

Energy metabolism plasticity enables stemness programs

Folmes, C., Nelson, T. J., Dzeja, P. P. & Terzic, A., Apr 2012, In : Annals of the New York Academy of Sciences. 1254, 1, p. 82-89 8 p.

Research output: Contribution to journalArticle

Energy Metabolism
Plasticity
Tissue
Organelle Biogenesis
Glycolysis
304 Citations (Scopus)

Metabolic plasticity in stem cell homeostasis and differentiation

Folmes, C., Dzeja, P. P., Nelson, T. J. & Terzic, A., Nov 2 2012, In : Cell Stem Cell. 11, 5, p. 596-606 11 p.

Research output: Contribution to journalArticle

Cell Differentiation
Homeostasis
Stem Cells
Epigenomics
Energy Metabolism
47 Citations (Scopus)

Mitochondria in control of cell fate

Folmes, C., Dzeja, P. P., Nelson, T. J. & Terzic, A., Feb 17 2012, In : Circulation Research. 110, 4, p. 526-529 4 p.

Research output: Contribution to journalArticle

Cell Lineage
Cardiac Myocytes
Mitochondria
Stem Cells
Embryonic Structures
2011
5 Citations (Scopus)

31P NMR correlation maps of 18O/16O chemical shift isotopic effects for phosphometabolite labeling studies

Juranić, N., Nemutlu, E., Zhang, S., Dzeja, P. P., Terzic, A. & Macura, S. I., Jul 2011, In : Journal of Biomolecular NMR. 50, 3, p. 237-245 9 p.

Research output: Contribution to journalArticle

Chemical shift
Isotopes
Labeling
Labels
Nuclear magnetic resonance
36 Citations (Scopus)

Developmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation

Dzeja, P. P., Chung, S., Faustino, R. S., Behfar, A. & Terzic, A., 2011, In : PLoS One. 6, 4, e19300.

Research output: Contribution to journalArticle

adenylate kinase
Adenylate Kinase
AMP-activated protein kinase
Stem cells
stem cells
35 Citations (Scopus)

Rearrangement of energetic and substrate utilization networks compensate for chronic myocardial creatine kinase deficiency

Dzeja, P. P., Hoyer, K., Tian, R., Zhang, S., Nemutlu, E., Spindler, M. & Ingwall, J. S., Nov 2011, In : Journal of Physiology. 589, 21, p. 5193-5211 19 p.

Research output: Contribution to journalArticle

MM Form Creatine Kinase
MB Form Creatine Kinase
Creatine Kinase
Mitochondrial Form Creatine Kinase
Adenylate Kinase
493 Citations (Scopus)

Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming

Folmes, C., Nelson, T. J., Martinez-Fernandez, A., Arrell, D. K., Lindor, J. Z., Dzeja, P. P., Ikeda, Y. H., Terzic, C. M. & Terzic, A., Aug 3 2011, In : Cell Metabolism. 14, 2, p. 264-271 8 p.

Research output: Contribution to journalArticle

Glycolysis
Energy Metabolism
Electron Transport Complex I
Induced Pluripotent Stem Cells
Metabolomics
34 Citations (Scopus)

Unique cellular and mitochondrial defects mediate FK506-induced islet β-cell dysfunction

Rostambeigi, N., Lanza, I. R., Dzeja, P. P., Deeds, M. C., Irving, B. A., Reddi, H. V., Madde, P., Zhang, S., Asmann, Y., Anderson, J. M., Schimke, J. M., Nair, K. S., Eberhardt, N. L. & Kudva, Y. C., Mar 27 2011, In : Transplantation. 91, 6, p. 615-623 9 p.

Research output: Contribution to journalArticle

Tacrolimus
Islets of Langerhans
Microarray Analysis
Insulin
Apoptosis
2010
86 Citations (Scopus)

Glycolytic network restructuring integral to the energetics of embryonic stem cell cardiac differentiation

Chung, S., Arrell, D. K., Faustino, R. S., Terzic, A. & Dzeja, P. P., Apr 2010, In : Journal of Molecular and Cellular Cardiology. 48, 4, p. 725-734 10 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Hexokinase
Cell Differentiation
Protein Isoforms
Glyceraldehyde-3-Phosphate Dehydrogenases
15 Citations (Scopus)

Metabolic assessment of a novel chronic myelogenous leukemic cell line and an imatinib resistant subline by 1H NMR spectroscopy

Dewar, B. J., Keshari, K., Jeffries, R., Dzeja, P. P., Graves, L. M. & Macdonald, J. M., 2010, In : Metabolomics. 6, 3, p. 439-450 12 p.

Research output: Contribution to journalArticle

Creatine
Nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
Metabolites
Cells
1 Citation (Scopus)

Where have the fluxes gone?

Aliev, M., Schlattner, U., Dzeja, P. P., Wallimann, T. & Saks, V., Dec 24 2010, In : Journal of Biological Chemistry. 285, 52

Research output: Contribution to journalArticle

Magnetic resonance spectroscopy
Mitochondria
Creatine Kinase
Rats
Animals
2009
194 Citations (Scopus)
adenosine monophosphate
Adenylate Kinase
Adenosine Monophosphate
Metabolic Networks and Pathways
communication
2008
8 Citations (Scopus)

Doppler Strain Imaging Closely Reflects Myocardial Energetic Status in Acute Progressive Ischemia and Indicates Energetic Recovery After Reperfusion

Korinek, J., Sengupta, P. P., Wang, J., Romero-Corral, A., Boukatina, A. E., Vitek, J., Krishnamoorthy, V. K., Cha, S. S., Dzeja, P. P., Terzic, A., Khandheria, B. K. & Belohlavek, M., Aug 2008, In : Journal of the American Society of Echocardiography. 21, 8, p. 961-968 8 p.

Research output: Contribution to journalArticle

Adenosine Diphosphate
Reperfusion
Ischemia
Adenosine Triphosphate
Echocardiography
54 Citations (Scopus)

Guided stem cell cardiopoiesis: Discovery and translation

Behfar, A., Faustino, R. S., Arrell, D. K., Dzeja, P. P., Terzic, C. M. & Terzic, A., Oct 2008, In : Journal of Molecular and Cellular Cardiology. 45, 4, p. 523-529 7 p.

Research output: Contribution to journalArticle

Adult Stem Cells
Stem Cells
Cell- and Tissue-Based Therapy
Embryonic Induction
Mesoderm
2007
29 Citations (Scopus)

Defective metabolic signaling in adenylate kinase AK1 gene knock-out hearts compromises post-ischemic coronary reflow

Dzeja, P. P., Bast, P., Pucar, D., Wieringa, B. & Terzic, A., Oct 26 2007, In : Journal of Biological Chemistry. 282, 43, p. 31366-31372 7 p.

Research output: Contribution to journalArticle

Adenylate Kinase
Gene Knockout Techniques
Genes
Blood Vessels
Adenosine Triphosphate
290 Citations (Scopus)
Embryonic Stem Cells
Electron Transport
Stem Cells
Mitochondrial Dynamics
Anaerobiosis
2006
16 Citations (Scopus)
Energy Metabolism
Myocardium
Phosphocreatine
Adenylate Kinase
Adenosine Triphosphate
178 Citations (Scopus)

Cardiac system bioenergetics: Metabolic basis of the frank-starling law

Saks, V., Dzeja, P. P., Schlattner, U., Vendelin, M., Terzic, A. & Wallimann, T., Mar 2006, In : Journal of Physiology. 571, 2, p. 253-273 21 p.

Research output: Contribution to journalArticle

Starlings
Energy Metabolism
Respiration
Adenylate Kinase
Calcium Signaling
2004
88 Citations (Scopus)

ATP-sensitive K+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits

Kane, G. M., Behfar, A., Yamada, S., Terzic, C. M., O'Cochlain, F., Reyes, S., Dzeja, P. P., Miki, T., Seino, S. & Terzic, A., Dec 2004, In : Diabetes. 53, SUPPL. 3

Research output: Contribution to journalArticle

KATP Channels
Adenosine Triphosphate
Exercise
Sulfonylurea Receptors
Wild Animals
12 Citations (Scopus)
Iodoacetamide
MB Form Creatine Kinase
Energy Metabolism
Troponin I
Creatine Kinase
34 Citations (Scopus)

Mapping hypoxia-induced bioenergetic rearrangement and metabolic signalling by 18O-assisted 31P NMR and 1 NMR spectroscopy

Pucar, D., Dzeja, P. P., Bast, P., Gumina, R. J., Drahl, C., Lim, L., Juranic, N., Macura, S. I. & Terzic, A., Jan 2004, In : Molecular and Cellular Biochemistry. 256-257, 1-2, p. 281-289 9 p.

Research output: Contribution to journalArticle

Adenylate Kinase
Energy Metabolism
Nuclear magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy
Creatine Kinase
83 Citations (Scopus)
Adenylate Kinase
KATP Channels
Creatine Kinase
Amplification
Nucleotides
53 Citations (Scopus)

Phosphotransfer dynamics in skeletal muscle from creatine kinase gene-deleted mice

Dzeja, P. P., Terzic, A. & Wieringa, B., Jan 2004, In : Molecular and Cellular Biochemistry. 256-257, 1-2, p. 13-27 15 p.

Research output: Contribution to journalArticle

MM Form Creatine Kinase
Creatine Kinase
Muscle
Skeletal Muscle
Adenylate Kinase
2003
35 Citations (Scopus)

Adenylate kinase 1 deficiency induces molecular and structural adaptations to support muscle energy metabolism

Janssen, E., De Groof, A., Wijers, M., Fransen, J., Dzeja, P. P., Terzic, A. & Wieringa, B., Apr 11 2003, In : Journal of Biological Chemistry. 278, 15, p. 12937-12945 9 p.

Research output: Contribution to journalArticle

Energy Metabolism
Muscle
Muscles
Skeletal Muscle
Mitochondrial Form Creatine Kinase
81 Citations (Scopus)
Atrial Remodeling
Myocardium
Heart Failure
Creatine Kinase
Adenylate Kinase
50 Citations (Scopus)

Impaired intracellular energetic communication in muscles from creatine kinase and adenylate kinase (M-CK/AK1) double knock-out mice

Janssen, E., Terzic, A., Wieringa, B. & Dzeja, P. P., Aug 15 2003, In : Journal of Biological Chemistry. 278, 33, p. 30441-30449 9 p.

Research output: Contribution to journalArticle

MM Form Creatine Kinase
Adenylate Kinase
Knockout Mice
Adenosine Triphosphate
Communication
118 Citations (Scopus)

Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics

Gumina, R. J., Pucar, D., Bast, P., Hodgson, D. M., Kurtz, C. E., Dzeja, P. P., Miki, T., Seino, S. & Terzic, A., Jun 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 6 53-6

Research output: Contribution to journalArticle

Ischemic Preconditioning
Adenosine Triphosphate
KATP Channels
Energy Metabolism
Energy Transfer
345 Citations (Scopus)

Phosphotransfer networks and cellular energetics

Dzeja, P. P. & Terzic, A., Jun 2003, In : Journal of Experimental Biology. 206, 12, p. 2039-2047 9 p.

Research output: Contribution to journalArticle

adenylate kinase
Adenylate Kinase
Energy Transfer
creatine kinase
Creatine Kinase
88 Citations (Scopus)

Targeting nucleotide-requiring enzymes: Implications for diazoxide-induced cardioprotection

Dzeja, P. P., Bast, P., Ozcan, C., Valverde, A., Holmuhamedov, E. L., Van Wylen, D. G. L. & Terzic, A., Apr 1 2003, In : American Journal of Physiology - Heart and Circulatory Physiology. 284, 4 53-4

Research output: Contribution to journalArticle

Diazoxide
Nucleotides
Enzymes
Succinate Dehydrogenase
Electron Transport
2002
47 Citations (Scopus)

Adenylate kinase AK1 knockout heart: Energetics and functional performance under ischemia-reperfusion

Pucar, D., Bast, P., Gumina, R. J., Lim, L., Drahl, C., Juranic, N., Macura, S. I., Janssen, E., Wieringa, B., Terzic, A. & Dzeja, P. P., 2002, In : American Journal of Physiology - Heart and Circulatory Physiology. 283, 2 52-2

Research output: Contribution to journalArticle

Adenylate Kinase
Reperfusion
Ischemia
Adenosine Triphosphate
Adenosine Diphosphate
125 Citations (Scopus)

Coupling of cell energetics with membrane metabolic sensing: Integrative signaling through creatine kinase phosphotransfer disrupted by M-CK gene knock-out

Roselle Abraham, M., Selivanov, V. A., Hodgson, D. M., Pucar, D., Zingman, L. V., Wieringa, B., Dzeja, P. P., Alekseev, A. E. & Terzic, A., Jul 5 2002, In : Journal of Biological Chemistry. 277, 27, p. 24427-24434 8 p.

Research output: Contribution to journalArticle

KATP Channels
Gene Knockout Techniques
Creatine Kinase
Genes
Membranes
113 Citations (Scopus)

Energetic communication between mitochondria and nucleus directed by catalyzed phosphotransfer

Dzeja, P. P., Bortolon, R., Terzic, C. M., Holmuhamedov, E. L. & Terzic, A., Jul 23 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 15, p. 10156-10161 6 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Mitochondria
Adenylate Kinase
Oxidative Phosphorylation
Creatine Kinase
247 Citations (Scopus)

Kir6.2 is required for adaptation to stress

Zingman, L. V., Hodgson, D. M., Bast, P. H., Kane, G. M., Terzic, C. M., Gumina, R. J., Pucar, D., Bienengraeber, M., Dzeja, P. P., Miki, T., Seino, S., Alekseev, A. E. & Terzic, A., Oct 1 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, 20, p. 13278-13283 6 p.

Research output: Contribution to journalArticle

KATP Channels
General Adaptation Syndrome
Calcium Channels
Sudden Death
Cardiac Arrhythmias