Petras P Dzeja, PhD

  • 6415 Citations
  • 40 Scopus h-Index
1980 …2020

Research output per year

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Research Output

2020

Adenylate Kinase and Metabolic Signaling in Cancer Cells

Klepinin, A., Zhang, S., Klepinina, L., Rebane-Klemm, E., Terzic, A., Kaambre, T. & Dzeja, P., May 19 2020, In : Frontiers in Oncology. 10, 660.

Research output: Contribution to journalReview article

Open Access
2019

Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity

Kazak, L., Rahbani, J. F., Samborska, B., Lu, G. Z., Jedrychowski, M. P., Lajoie, M., Zhang, S., Ramsay, L. A., Dou, F. Y., Tenen, D., Chouchani, E. T., Dzeja, P., Watson, I. R., Tsai, L., Rosen, E. D. & Spiegelman, B. M., Mar 1 2019, In : Nature Metabolism. 1, 3, p. 360-370 11 p.

Research output: Contribution to journalArticle

Open Access
24 Scopus citations
Open Access
2018

First and second trimester urinary metabolic profiles and fetal growth restriction: An exploratory nested case-control study within the infant development and environment study

Luthra, G., Vuckovic, I., Bangdiwala, A., Gray, H., Redmon, J. B., Barrett, E. S., Sathyanarayana, S., Nguyen, R. H. N., Swan, S. H., Zhang, S., Dzeja, P., Macura, S. I. & Nair, K. S., Feb 8 2018, In : BMC Pregnancy and Childbirth. 18, 1, 48.

Research output: Contribution to journalArticle

4 Scopus citations

Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation

Wang, F., Zhang, S., Vuckovic, I., Jeon, R., Lerman, A., Folmes, C., Dzeja, P. P. & Herrmann, J., Sep 4 2018, In : Cell Metabolism. 28, 3, p. 463-475.e4

Research output: Contribution to journalArticle

37 Scopus citations

Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity

Wang, F., Zhang, S., Jeon, R., Vuckovic, I., Jiang, X., Lerman, A., Folmes, C., Dzeja, P. P. & Herrmann, J., Jan 1 2018, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

27 Scopus citations

Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers

Mondal, S., Roy, D., Sarkar Bhattacharya, S., Jin, L., Jung, D., Zhang, S., Kalogera, E., Staub, J., Wang, Y., Xuyang, W., Khurana, A., Chien, J., Telang, S., Chesney, J., Tapolsky, G., Dzeja, P. P. & Shridhar, V., Jan 1 2018, (Accepted/In press) In : International Journal of Cancer.

Research output: Contribution to journalArticle

14 Scopus citations
2017

Erratum: Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity (Cell Metabolism (2017) 26(4) (660–671.e3) (S1550413117304941)(10.1016/j.cmet.2017.08.009))

Kazak, L., Chouchani, E. T., Lu, G. Z., Jedrychowski, M. P., Bare, C. J., Mina, A. I., Kumari, M., Zhang, S., Vuckovic, I., Laznik-Bogoslavski, D., Dzeja, P. P., Banks, A. S., Rosen, E. D. & Spiegelman, B. M., Oct 3 2017, In : Cell Metabolism. 26, 4, 1 p.

Research output: Contribution to journalComment/debate

16 Scopus citations

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity

Kazak, L., Chouchani, E. T., Lu, G. Z., Jedrychowski, M. P., Bare, C. J., Mina, A. I., Kumari, M., Zhang, S., Vuckovic, I., Laznik-Bogoslavski, D., Dzeja, P. P., Banks, A. S., Rosen, E. D. & Spiegelman, B. M., 2017, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

58 Scopus citations
2016

The Modulating Effects of Cardiac Resynchronization Therapy on Myocardial Metabolism in Heart Failure

Xu, Y. Z., Chen, C. F., Chen, B., Gao, X. F., Hua, W., Cha, Y. M. & Dzeja, P. P., Dec 1 2016, In : PACE - Pacing and Clinical Electrophysiology. 39, 12, p. 1404-1409 6 p.

Research output: Contribution to journalReview article

4 Scopus citations
2015

<sup>18</sup>O-assisted <sup>31</sup>P NMR and mass spectrometry for phosphometabolomic fingerprinting and metabolic monitoring

Nemutlu, E., Zhang, S., Terzic, A. & Dzeja, P. P., 2015, In : Issues in Toxicology. 2015-January, 21, p. 255-286 32 p.

Research output: Contribution to journalArticle

1 Scopus citations

Cardiac resynchronization therapy induces adaptive metabolic transitions in the metabolomic profile of heart failure

Nemutlu, E., Zhang, S., Xu, Y. Z., Terzic, A., Zhong, L., Dzeja, P. P. & Cha, Y-M., Jun 1 2015, In : Journal of Cardiac Failure. 21, 6, p. 460-469 10 p.

Research output: Contribution to journalArticle

27 Scopus citations

Decline of phosphotransfer and substrate supply metabolic circuits hinders ATP cycling in aging myocardium

Nemutlu, E., Gupta, A., Zhang, S., Viqar, M., Holmuhamedov, E., Terzic, A., Jahangir, A. & Dzeja, P., Sep 17 2015, In : PloS one. 10, 9, e0136556.

Research output: Contribution to journalArticle

5 Scopus citations

Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation

Guzun, R., Kaambre, T., Bagur, R., Grichine, A., Usson, Y., Varikmaa, M., Anmann, T., Tepp, K., Timohhina, N., Shevchuk, I., Chekulayev, V., Boucher, F., Dos Santos, P., Schlattner, U., Wallimann, T., Kuznetsov, A. V., Dzeja, P. P., Aliev, M. & Saks, V., Jan 1 2015, In : Acta Physiologica. 213, 1, p. 84-106 23 p.

Research output: Contribution to journalArticle

31 Scopus citations

Modulation of Mitochondrial Complex I Activity Averts Cognitive Decline in Multiple Animal Models of Familial Alzheimer's Disease

Zhang, L., Zhang, S., Maezawa, I., Trushin, S., Minhas, P., Pinto, M., Jin, L. W., Prasain, K., Nguyen, T. D. T., Yamazaki, Y., Kanekiyo, T., Bu, G. D., Gateno, B., Chang, K. O., Nath, K. A., Nemutlu, E., Dzeja, P. P., Pang, Y-P., Hua, D. H. & Trushina, E. D., Apr 1 2015, In : EBioMedicine. 2, 4, p. 294-305 12 p.

Research output: Contribution to journalArticle

29 Scopus citations
2014

A pharmaco-metabonomic study on chronic kidney disease and therapeutic effect of Ergone by UPLC-QTOF/HDMS

Zhao, Y. Y., Chen, H., Tian, T., Chen, D. Q., Bai, X., Wei, F. & Dzeja, P., Dec 23 2014, In : PloS one. 9, 12, e115467.

Research output: Contribution to journalArticle

52 Scopus citations
2012

18O-assisted dynamic metabolomics for individualized diagnostics and treatment of human diseases

Nemutlu, E., Zhang, S., Juranic, N. O., Terzic, A., Macura, S. & Dzeja, P., Dec 1 2012, In : Croatian Medical Journal. 53, 6, p. 529-534 6 p.

Research output: Contribution to journalReview article

9 Scopus citations

Compartmentation of membrane processes and nucleotide dynamics in diffusion-restricted cardiac cell microenvironment

Alekseev, A. E., Reyes, S., Selivanov, V. A., Dzeja, P. P. & Terzic, A., Feb 1 2012, In : Journal of Molecular and Cellular Cardiology. 52, 2, p. 401-409 9 p.

Research output: Contribution to journalReview article

34 Scopus citations

Defects in mitochondrial dynamics and metabolomic signatures of evolving energetic stress in mouse models of familial alzheimer's disease

Trushina, E., Nemutlu, E., Zhang, S., Christensen, T., Camp, J., Mesa, J., Siddiqui, A., Tamura, Y., Sesaki, H., Wengenack, T. M., Dzeja, P. P. & Poduslo, J. F., Feb 29 2012, In : PloS one. 7, 2, e32737.

Research output: Contribution to journalArticle

151 Scopus citations

Dynamic phosphometabolomic profiling of human tissues and transgenic models by 18O-assisted 31P NMR and mass spectrometry

Nemutlu, E., Zhang, S., Gupta, A., Juranic, N. O., Macura, S. I., Terzic, A., Jahangir, A. & Dzeja, P., Apr 1 2012, In : Physiological Genomics. 44, 7, p. 386-402 17 p.

Research output: Contribution to journalArticle

16 Scopus citations

Electron spray ionization mass spectrometry and 2D 31P NMR for monitoring 18O/16O isotope exchange and turnover rates of metabolic oligophosphates

Nemutlu, E., Juranic, N., Zhang, S., Ward, L. E., Dutta, T., Sreekumaran Nair, K., Terzic, A., Macura, S. & Dzeja, P. P., May 1 2012, In : Analytical and bioanalytical chemistry. 403, 3, p. 697-706 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Energy metabolism plasticity enables stemness programs

Folmes, C. D. L., Nelson, T. J., Dzeja, P. P. & Terzic, A., Apr 2012, In : Annals of the New York Academy of Sciences. 1254, 1, p. 82-89 8 p.

Research output: Contribution to journalArticle

65 Scopus citations

Metabolic plasticity in stem cell homeostasis and differentiation

Folmes, C. D. L., Dzeja, P. P., Nelson, T. J. & Terzic, A., Nov 2 2012, In : Cell Stem Cell. 11, 5, p. 596-606 11 p.

Research output: Contribution to journalReview article

335 Scopus citations

Mitochondria in control of cell fate

Folmes, C. D. L., Dzeja, P. P., Nelson, T. J. & Terzic, A., Feb 17 2012, In : Circulation research. 110, 4, p. 526-529 4 p.

Research output: Contribution to journalArticle

49 Scopus citations
2011

31P NMR correlation maps of 18O/16O chemical shift isotopic effects for phosphometabolite labeling studies

Juranić, N., Nemutlu, E., Zhang, S., Dzeja, P., Terzic, A. & MacUra, S., Jul 1 2011, In : Journal of Biomolecular NMR. 50, 3, p. 237-245 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Developmental enhancement of adenylate kinase-AMPK metabolic signaling axis supports stem cell cardiac differentiation

Dzeja, P. P., Chung, S., Faustino, R. S., Behfar, A. & Terzic, A., 2011, In : PloS one. 6, 4, e19300.

Research output: Contribution to journalArticle

39 Scopus citations

Rearrangement of energetic and substrate utilization networks compensate for chronic myocardial creatine kinase deficiency

Dzeja, P. P., Hoyer, K., Tian, R., Zhang, S., Nemutlu, E., Spindler, M. & Ingwall, J. S., Nov 1 2011, In : Journal of Physiology. 589, 21, p. 5193-5211 19 p.

Research output: Contribution to journalArticle

39 Scopus citations

Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming

Folmes, C. D. L., Nelson, T. J., Martinez-Fernandez, A., Arrell, D. K., Lindor, J. Z., Dzeja, P. P., Ikeda, Y., Perez-Terzic, C. & Terzic, A., Aug 3 2011, In : Cell Metabolism. 14, 2, p. 264-271 8 p.

Research output: Contribution to journalArticle

537 Scopus citations

Unique cellular and mitochondrial defects mediate FK506-induced islet β-cell dysfunction

Rostambeigi, N., Lanza, I. R., Dzeja, P. P., Deeds, M. C., Irving, B. A., Reddi, H. V., Madde, P., Zhang, S., Asmann, Y. W., Anderson, J. M., Schimke, J. M., Nair, K. S., Eberhardt, N. L. & Kudva, Y. C., Mar 27 2011, In : Transplantation. 91, 6, p. 615-623 9 p.

Research output: Contribution to journalArticle

35 Scopus citations
2010

Glycolytic network restructuring integral to the energetics of embryonic stem cell cardiac differentiation

Chung, S., Arrell, D. K., Faustino, R. S., Terzic, A. & Dzeja, P. P., Apr 1 2010, In : Journal of Molecular and Cellular Cardiology. 48, 4, p. 725-734 10 p.

Research output: Contribution to journalArticle

98 Scopus citations

Metabolic assessment of a novel chronic myelogenous leukemic cell line and an imatinib resistant subline by 1H NMR spectroscopy

Dewar, B. J., Keshari, K., Jeffries, R., Dzeja, P., Graves, L. M. & Macdonald, J. M., Mar 22 2010, In : Metabolomics. 6, 3, p. 439-450 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

Where have the fluxes gone?

Aliev, M., Schlattner, U., Dzeja, P., Wallimann, T. & Saks, V., Dec 24 2010, In : Journal of Biological Chemistry. 285, 52, p. le21

Research output: Contribution to journalLetter

1 Scopus citations
2009
219 Scopus citations
2008

Developmental restructuring of the creatine kinase system integrates mitochondrial energetics with stem cell cardiogenesis

Chung, S., Dzeja, P. P., Faustino, R. S. & Terzic, A., Dec 2008, Mitochondria and Oxidative Stress in Neurodegenerative Disorders. Blackwell Publishing Inc., p. 254-263 10 p. (Annals of the New York Academy of Sciences; vol. 1147).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

30 Scopus citations

Doppler Strain Imaging Closely Reflects Myocardial Energetic Status in Acute Progressive Ischemia and Indicates Energetic Recovery After Reperfusion

Korinek, J., Sengupta, P. P., Wang, J., Romero-Corral, A., Boukatina, A. E., Vitek, J., Krishnamoorthy, V. K., Cha, S. S., Dzeja, P. P., Terzic, A., Khandheria, B. K. & Belohlavek, M., Aug 1 2008, In : Journal of the American Society of Echocardiography. 21, 8, p. 961-968 8 p.

Research output: Contribution to journalArticle

8 Scopus citations

Guided stem cell cardiopoiesis: Discovery and translation

Behfar, A., Faustino, R. S., Arrell, D. K., Dzeja, P. P., Perez-Terzic, C. & Terzic, A., Oct 1 2008, In : Journal of Molecular and Cellular Cardiology. 45, 4, p. 523-529 7 p.

Research output: Contribution to journalReview article

56 Scopus citations
2007

Defective metabolic signaling in adenylate kinase AK1 gene knock-out hearts compromises post-ischemic coronary reflow

Dzeja, P. P., Bast, P., Pucar, D., Wieringa, B. & Terzic, A., Oct 26 2007, In : Journal of Biological Chemistry. 282, 43, p. 31366-31372 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Integrated and Organized Cellular Energetic Systems: Theories of Cell Energetics, Compartmentation, and Metabolic Channeling

Saks, V., Monge, C., Anmann, T. & Dzeja, P. P., Nov 22 2007, Molecular System Bioenergetics: Energy for Life. Wiley-VCH Verlag GmbH & Co. KGaA, p. 59-109 51 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Scopus citations

Integration of Adenylate Kinase and Glycolytic and Glycogenolytic Circuits in Cellular Energetics

Dzeja, P. P., Chung, S. & Terzic, A., Nov 22 2007, Molecular System Bioenergetics: Energy for Life. Wiley-VCH Verlag GmbH & Co. KGaA, p. 265-301 37 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

33 Scopus citations

Mitochondrial oxidative metabolism is required for the cardiac differentiation of stem cells

Chung, S., Dzeja, P. P., Faustino, R. S., Perez-Terzic, C., Behfar, A. & Terzic, A., Feb 1 2007, In : Nature Clinical Practice Cardiovascular Medicine. 4, SUPPL. 1, p. S60-S67

Research output: Contribution to journalArticle

309 Scopus citations

Mitochondria-nucleus energetic communication: Role for phosphotransfer networks in processing cellular information

Dzeja, P. P. & Terzic, A., Dec 1 2007, Handbook of Neurochemistry and Molecular Neurobiology: Brain Energetics. Integration of Molecular and Cellular Processes. Springer US, p. 641-666 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

System Analysis of Cardiac Energetics-Excitation-Contraction Coupling: Integration of Mitochondrial Respiration, Phosphotransfer Pathways, Metabolic Pacing, and Substrate Supply in the Heart

Saks, V., Dzeja, P. P., Guzun, R., Aliev, M. K., Vendelin, M., Terzic, A. & Wallimann, T., Nov 22 2007, Molecular System Bioenergetics: Energy for Life. Wiley-VCH Verlag GmbH & Co. KGaA, p. 367-405 39 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations
2006
16 Scopus citations

Cardiac system bioenergetics: Metabolic basis of the frank-starling law

Saks, V., Dzeja, P., Schlattner, U., Vendelin, M., Terzic, A. & Wallimann, T., Mar 1 2006, In : Journal of Physiology. 571, 2, p. 253-273 21 p.

Research output: Contribution to journalReview article

186 Scopus citations
2004

ATP-sensitive K+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits

Kane, G. C., Behfar, A., Yamada, S., Perez-Terzic, C., O'Cochlain, F., Reyes, S., Dzeja, P. P., Miki, T., Seino, S. & Terzic, A., Dec 1 2004, In : Diabetes. 53, SUPPL. 3, p. S169-S175

Research output: Contribution to journalArticle

88 Scopus citations
12 Scopus citations

Mapping hypoxia-induced bioenergetic rearrangement and metabolic signalling by 18O-assisted 31P NMR and 1 NMR spectroscopy

Pucar, D., Dzeja, P. P., Bast, P., Gumina, R. J., Drahl, C., Lim, L., Juranic, N., Macura, S. & Terzic, A., 2004, In : Molecular and Cellular Biochemistry. 256-257, 1-2, p. 281-289 9 p.

Research output: Contribution to journalReview article

33 Scopus citations
84 Scopus citations

Phosphotransfer dynamics in skeletal muscle from creatine kinase gene-deleted mice

Dzeja, P. P., Terzic, A. & Wieringa, B., 2004, In : Molecular and Cellular Biochemistry. 256-257, 1-2, p. 13-27 15 p.

Research output: Contribution to journalReview article

55 Scopus citations
2003

Adenylate kinase 1 deficiency induces molecular and structural adaptations to support muscle energy metabolism

Janssen, E., De Groof, A., Wijers, M., Fransen, J., Dzeja, P. P., Terzic, A. & Wieringa, B., Apr 11 2003, In : Journal of Biological Chemistry. 278, 15, p. 12937-12945 9 p.

Research output: Contribution to journalArticle

37 Scopus citations