• 4998 Citations
  • 38 Scopus h-Index
1984 …2017

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Adenovirus type 5 vectors induce dendritic cell differentiation in human CD14 + monocytes cultured under serum-free conditions

Lyakh, L. A., Koski, G. K., Young, H. A., Spence, S. E., Cohen, P. A. & Rice, N. R., Jan 15 2002, In : Blood. 99, 2, p. 600-608 9 p.

Research output: Contribution to journalArticle

39 Scopus citations

Adoptive immunotherapy of cancer with polyclonal, 108-fold hyperexpanded, CD4+ and CD8+T cells

Wang, L. X., Huang, W. X., Graor, H., Cohen, P. A., Kim, J. A., Shu, S. & Plautz, G. E., Nov 26 2004, In : Journal of Translational Medicine. 2

Research output: Contribution to journalArticle

24 Scopus citations

Adoptive transfer of MART-1 T-cell receptor transgenic lymphocytes and dendritic cell vaccination in patients with metastatic melanoma

Chodon, T., Comin-Anduix, B., Chmielowski, B., Koya, R. C., Wu, Z., Auerbach, M., Ng, C., Avramis, E., Seja, E., Villanueva, A., McCannel, T. A., Ishiyama, A., Czernin, J., Radu, C. G., Wang, X., Gjertson, D. W., Cochran, A. J., Cornetta, K., Wong, D. J. L., Kaplan-Lefko, P. & 14 others, Hamid, O., Samlowski, W., Cohen, P. A., Daniels, G. A., Mukherji, B., Yang, L., Zack, J. A., Kohn, D. B., Heath, J. R., Glaspy, J. A., Witte, O. N., Baltimore, D., Economou, J. S. & Ribas, A., May 1 2014, In : Clinical Cancer Research. 20, 9, p. 2457-2465 9 p.

Research output: Contribution to journalArticle

107 Scopus citations

A phase I dose-finding study of the novel toll-like receptor 8 agonist VTX-2337 in adult subjects with advanced solid tumors or lymphoma

Northfelt, D. W., Ramanathan, R. K., Cohen, P. A., Von Hoff, D. D., Weiss, G. J., Dietsch, G. N., Manjarrez, K. L., Randall, T. D. & Hershberg, R. M., Jul 15 2014, In : Clinical Cancer Research. 20, 14, p. 3683-3691 9 p.

Research output: Contribution to journalArticle

29 Scopus citations

A randomized phase 2 study of temozolomide and bevacizumab or nab-paclitaxel, carboplatin, and bevacizumab in patients with unresectable stage IV melanoma: A North Central Cancer Treatment Group study, N0775

Kottschade, L. A., Suman, V. J., Perez, D. G., McWilliams, R. R., Kaur, J. S., Amatruda, T. T., Geoffroy, F. J., Gross, H. M., Cohen, P. A., Jaslowski, A. J., Kosel, M. L. & Markovic, S. N., Feb 1 2013, In : Cancer. 119, 3, p. 586-592 7 p.

Research output: Contribution to journalArticle

57 Scopus citations

Augmentation versus inhibition: Effects of conjunctional OX-40 receptor monoclonal antibody and IL-2 treatment on adoptive immunotherapy of advanced tumor

Kjaergaard, J., Peng, L., Cohen, P. A., Drazba, J. A., Weinberg, A. D. & Shu, S., Dec 1 2001, In : Journal of Immunology. 167, 11, p. 6669-6677 9 p.

Research output: Contribution to journalArticle

Open Access
62 Scopus citations

Bacterial lipopolysaccharide, TNF-α, and calcium ionophore under serum-free conditions promote rapid dendritic cell-like differentiation in CD14+ monocytes through distinct pathways that activate NF-κB

Lyakh, L. A., Koski, G. K., Telford, W., Gress, R. E., Cohen, P. A. & Rice, N. R., Oct 1 2000, In : Journal of Immunology. 165, 7, p. 3647-3655 9 p.

Research output: Contribution to journalArticle

Open Access
108 Scopus citations

Calcium ionophore activation of chronic myelogenous leukemia progenitor cells into dendritic cells is mediated by calcineurin phosphatase

Engels, F. H. C., Kreisel, D., Faries, M. B., Bedrosian, I., Koski, G. K., Cohen, P. A. & Czerniecki, B. J., Oct 1 2000, In : Leukemia Research. 24, 10, p. 795-804 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Calcium ionophore-treated myeloid cells acquire many dendritic cell characteristics independent of prior differentiation state, transformation status, or sensitivity to biologic agents

Koski, G. K., Schwartz, G. N., Weng, D. E., Gress, R. E., Engels, F. H. C., Tsokos, M., Czerniecki, B. J. & Cohen, P. A., Aug 15 1999, In : Blood. 94, 4, p. 1359-1371 13 p.

Research output: Contribution to journalArticle

64 Scopus citations

Calcium Ionophore-Treated Peripheral Blood Monocytes and Dendritic Cells Rapidly Display Characteristics of Activated Dendritic Cells

Czerniecki, B. J., Carter, C., Rivoltini, L., Koski, G. K., Kim, H. I., Weng, D. E., Roros, J. G., Hijazi, Y. M., Xu, S., Rosenberg, S. A. & Cohen, P. A., Oct 15 1997, In : Journal of Immunology. 159, 8, p. 3823-3837 15 p.

Research output: Contribution to journalArticle

162 Scopus citations

Calcium mobilization in human myeloid cells results in acquisition of individual dendritic cell-like characteristics through discrete signaling pathways

Koski, G. K., Schwartz, G. N., Weng, D. E., Czerniecki, B. J., Carter, C., Gress, R. E. & Cohen, P. A., Jul 1 1999, In : Journal of Immunology. 163, 1, p. 82-92 11 p.

Research output: Contribution to journalArticle

84 Scopus citations

Calcium signaling induces acquisition of dendritic cell characteristics in chronic myelogenous leukemia myeloid progenitor cells

Engels, F. H. C., Koski, G. K., Bedrosian, I., Xu, S., Luger, S., Nowell, P. C., Cohen, P. A. & Czerniecki, B. J., Aug 31 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 18, p. 10332-10337 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Calcium signaling inhibits interleukin-12 production and activates CD83 + dendritic cells that induce Th2 cell development

Faries, M. B., Bedrosian, I., Xu, S., Koski, G., Roros, J. G., Moise, M. A., Nguyen, H. Q., Engels, F. H. C., Cohen, P. A. & Czerniecki, B. J., Oct 15 2001, In : Blood. 98, 8, p. 2489-2497 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

CD14+ monocytes as dendritic cell precursors: Diverse maturation-inducing pathways lead to common activation of NF-κB/RelB

Koski, G. K., Lyakh, L. A., Cohen, P. A. & Rice, N. R., Oct 23 2001, In : Critical reviews in immunology. 21, 1-3, p. 179-189 11 p.

Research output: Contribution to journalArticle

44 Scopus citations

CD4+ T-Cells from Mice Immunized to Syngeneic Sarcomas Recognize Distinct, Non-Shared Tumor Antigens

Cohen, P. A., Cohen, P. J., Rosenberg, S. A. & Mulé, J. J., Feb 1994, In : Cancer research. 54, 4, p. 1055-1058 4 p.

Research output: Contribution to journalArticle

42 Scopus citations

Cells of Th2 cytokine phenotype prevent LPS-induced lethality during murine graft-versus-host reaction: Regulation of cytokines and CD8+ lymphoid engraftment

Fowler, D. H., Kurasawa, K., Husebekk, A., Cohen, P. A. & Gress, R. E., Jan 1 1994, In : Journal of Immunology. 152, 3, p. 1004-1013 10 p.

Research output: Contribution to journalArticle

135 Scopus citations

Chemotherapy can induce weight normalization of morbidly obese mice despite undiminished ingestion of high fat diet

Myers, C. E., Hoelzinger, D. B., Truong, T. N., Chew, L. A., Myles, A., Chaudhuri, L., Egan, J. B., Liu, J., Gendler, S. J. & Cohen, P. A., 2017, In : Oncotarget. 8, 3, p. 5426-5438 13 p.

Research output: Contribution to journalArticle

2 Scopus citations

Combination of sunitinib with anti-tumor vaccination inhibits T cell priming and requires careful scheduling to achieve productive immunotherapy

Jaini, R., Rayman, P., Cohen, P. A., Finke, J. H. & Tuohy, V. K., Apr 1 2014, In : International Journal of Cancer. 134, 7, p. 1695-1705 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Cross-presentation of tumor antigens to effector T cells is sufficient to mediate effective immunotherapy of established intracranial tumors

Plautz, G. E., Mukai, S., Cohen, P. A. & Shu, S., Oct 1 2000, In : Journal of Immunology. 165, 7, p. 3656-3662 7 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations

Cutting Edge: Innate Immune System Discriminates between RNA Containing Bacterial versus Eukaryotic Structural Features That Prime for High-Level, IL-12 Secretion by Dendritic Cells

Koski, G. K., Karikó, K., Xu, S., Weissman, D., Cohen, P. A. & Czerniecki, B. J., Apr 1 2004, In : Journal of Immunology. 172, 7, p. 3989-3993 5 p.

Research output: Contribution to journalArticle

Open Access
83 Scopus citations

Defective major histocompatibility complex class i expression in a sarcomatoid renal cell carcinoma cell line

Jakobsen, M. K., Restifo, N. P., Cohen, P. A., Marincola, F. M., Bryan Cheshire, L., Marston Linehan, W., Rosenberg, S. A. & Alexander, R. B., May 1995, In : Journal of Immunotherapy. 17, 4, p. 222-228 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Tolllike receptor agonists

Manrique, S. Z., Dominguez, A. L., Mirza, N., Spencer, C. D., Bradley, J. M., Finke, J. H., Lee, J. J., Pease, L. R., Gendler, S. J. & Cohen, P. A., 2016, In : Oncotarget. 7, 28, p. 42919-42942 24 p.

Research output: Contribution to journalArticle

13 Scopus citations

Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained

Ko, J. S., Rayman, P., Ireland, J., Swaidani, S., Li, G., Bunting, K. D., Rini, B., Finke, J. H. & Cohen, P. A., May 1 2010, In : Cancer research. 70, 9, p. 3526-3536 11 p.

Research output: Contribution to journalArticle

205 Scopus citations

Diverse functional activity of CD83+ monocyte-derived dendritic cells and the implications for cancer vaccines

Czerniecki, B. J., Cohen, P. A., Faries, M., Xu, S., Roros, J. G. & Bedrosian, I., Oct 23 2001, In : Critical reviews in immunology. 21, 1-3, p. 157-178 22 p.

Research output: Contribution to journalArticle

38 Scopus citations

Downregulation of hematopoietic MUC1 during Experimental colitis increases tumor-promoting myeloid-derived suppressor cells

Poh, T. W., Madsen, C. S., Gorman, J. E., Marler, R. J., Leighton, J. A., Cohen, P. A. & Gendler, S. J., Sep 15 2013, In : Clinical Cancer Research. 19, 18, p. 5039-5052 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

Effective treatment of spontaneous metastases derived from a poorly immunogenic murine mammary carcinoma by combined dendritic-tumor hybrid vaccination and adoptive transfer of sensitized T cells

Tamai, H., Watanabe, S., Zheng, R., Deguchi, K., Cohen, P. A., Koski, G. K. & Shu, S., Apr 1 2008, In : Clinical Immunology. 127, 1, p. 66-77 12 p.

Research output: Contribution to journalArticle

25 Scopus citations

Effect of multiple activation stimuli on the generation of Th1-polarizing dendritic cells

Paustian, C., Caspell, R., Johnson, T., Cohen, P. A., Shu, S., Xu, S., Czerniecki, B. J. & Koski, G. K., Jan 1 2011, In : Human Immunology. 72, 1, p. 24-31 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Extracellular ATP and Toll-Like Receptor 2 Agonists Trigger in Human Monocytes an Activation Program That Favors T Helper 17

Paustian, C., Taylor, P., Johnson, T., Xu, M., Ramirez, N., Rosenthal, K. S., Shu, S., Cohen, P. A., Czerniecki, B. J. & Koski, G. K., Jan 31 2013, In : PloS one. 8, 1, e54804.

Research output: Contribution to journalArticle

19 Scopus citations

Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes pathways for monocyte-mediated protein nitration and lipid peroxidation in vivo

Hazen, S. L., Zhang, R., Shen, Z., Wu, W., Podrez, E. A., MacPherson, J. C., Schmitt, D., Mitra, S. N., Mukhopadhyay, C., Chen, Y., Cohen, P. A., Hoff, H. F. & Abu-Soud, H. M., Nov 12 1999, In : Circulation research. 85, 10, p. 950-958 9 p.

Research output: Contribution to journalArticle

Open Access
190 Scopus citations

Granulocyte-macrophage colony-stimulating factor, interleukin-2, and interleukin-12 synergize with calcium ionophore to enhance dendritic cell function

Bedrosian, I., Roros, J. G., Xu, S., Nguyen, H. Q., Engels, F., Faries, M. B., Czerniecki, B. J., Koski, G. K. & Cohen, P. A., 2000, In : Journal of Immunotherapy. 23, 3, p. 2675 1 p.

Research output: Contribution to journalArticle

Granulocyte-macrophage colony-stimulating factor, interleukin-2, and interleukin-12 synergize with calcium ionophore to enhance dendritic cell function

Bedrosian, I., Roros, J. G., Xu, S., Nguyen, H. Q., Engels, F., Faries, M. B., Koski, G. K., Cohen, P. A. & Czerniecki, B. J., May 1 2000, In : Journal of Immunotherapy. 23, 3, p. 311-320 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Helper-independent, L-selectin(low) CD8+ T cells with broad anti-tumor efficacy are naturally sensitized during tumor progression

Peng, L., Kjaergaard, J., Plautz, G. E., Weng, D. E., Shu, S. & Cohen, P. A., Nov 15 2000, In : Journal of Immunology. 165, 10, p. 5738-5749 12 p.

Research output: Contribution to journalArticle

Open Access
28 Scopus citations

Helper T Cells Infiltrating Human Renal Cell Carcinomas Have the Phenotype of Activated Memory-Like T Lymphocytes

Alexander, R. B., Fitzgerald, E. B., Mixon, A., Carter, C. S., Jakobsen, M., Cohen, P. A. & Rosenberg, S. A., Jan 1995, In : Journal of Immunotherapy. 17, 1, p. 39-46 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Human IgE synthesis in vitro by pokeweed mitogen-stimulated human lymphoid cells: Verification with a reconfirmed ε-specific radioimmunoassay

Chen, P. P., Nonaka, M., O'Hair, C. H., Cohen, P. A., Zuraw, B. L. & Katz, D. H., Nov 8 1984, In : Journal of Immunology. 133, 4, p. 1909-1913 5 p.

Research output: Contribution to journalArticle

9 Scopus citations

Immune and anticancer responses elicited by fully synthetic aberrantly glycosylated MUC1 tripartite vaccines modified by a TLR2 or TLR9 agonist

Abdel-Aal, A. B. M., Lakshminarayanan, V., Thompson, P., Supekar, N., Bradley, J. M., Wolfert, M. A., Cohen, P. A., Gendler, S. J. & Boons, G. J., Jul 7 2014, In : ChemBioChem. 15, 10, p. 1508-1513 6 p.

Research output: Contribution to journalArticle

39 Scopus citations

Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine

Lakshminarayanan, V., Thompson, P., Wolfert, M. A., Buskas, T., Bradley, J. M., Pathangey, L. B., Madsen, C. S., Cohen, P. A., Gendler, S. J. & Boons, G. J., Jan 3 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 1, p. 261-266 6 p.

Research output: Contribution to journalArticle

201 Scopus citations

Immunogenicity and therapeutic efficacy of dendritic-tumor hybrid cells generated by electrofusion

Hayashi, T., Tanaka, H., Tanaka, J., Wang, R., Averbook, B. J., Cohen, P. A. & Shu, S., Jan 1 2002, In : Clinical Immunology. 104, 1, p. 14-20 7 p.

Research output: Contribution to journalArticle

75 Scopus citations

Immunotherapy of established murine squamous cell carcinoma using fused dendritic-tumor cell hybrids

Lee, W. T., Tamai, H., Cohen, P., Teker, A. M. & Shu, S., Jun 2008, In : Archives of Otolaryngology - Head and Neck Surgery. 134, 6, p. 608-613 6 p.

Research output: Contribution to journalArticle

5 Scopus citations

Immunotherapy using allogeneic squamous cell tumor-dendritic cell fusion hybrids

Lee, W. T., Tan, C., Koski, G., Shu, S. & Cohen, P., Sep 1 2010, In : Head and Neck. 32, 9, p. 1209-1216 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Inhibition of adaptive immunity by IL9 can be disrupted to achieve rapid t-cell sensitization and rejection of progressive tumor challenges

Hoelzinger, D. B., Dominguez, A. L., Cohen, P. A. & Gendler, S. J., Dec 1 2014, In : Cancer research. 74, 23, p. 6845-6855 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Intranodal administration of peptide-pulsed mature dendritic cell vaccines results in superior CD8+ T-cell function in melanoma patients

Bedrosian, I., Mick, R., Xu, S., Nisenbaum, H., Faries, M., Zhang, P., Cohen, P. A., Koski, G. & Czerniecki, B. J., Oct 15 2003, In : Journal of Clinical Oncology. 21, 20, p. 3826-3835 10 p.

Research output: Contribution to journalArticle

145 Scopus citations

J-LEAPS vaccines initiate murine Th1 responses by activating dendritic cells

Taylor, P. R., Koski, G. K., Paustian, C. C., Bailey, E., Cohen, P. A., Moore, F. B. G., Zimmerman, D. H. & Rosenthal, K. S., Aug 1 2010, In : Vaccine. 28, 34, p. 5533-5542 10 p.

Research output: Contribution to journalArticle

15 Scopus citations

Late-stage cancer patients remain highly responsive to immune activation by the selective TLR8 agonist motolimod (VTX-2337)

Dietsch, G. N., Randall, T. D., Gottardo, R., Northfelt, D. W., Ramanathan, R. K., Cohen, P. A., Manjarrez, K. L., Newkirk, M., Bryan, J. K. & Hershberg, R. M., Dec 15 2015, In : Clinical Cancer Research. 21, 24, p. 5445-5452 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide

Thompson, P., Lakshminarayanan, V., Supekar, N. T., Bradley, J. M., Cohen, P. A., Wolfert, M. A., Gendler, S. J. & Boons, G. J., May 28 2015, In : Chemical Communications. 51, 50, p. 10214-10217 4 p.

Research output: Contribution to journalArticle

26 Scopus citations

Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species

Podrez, E. A., Febbraio, M., Sheibani, N., Schmitt, D., Silverstein, R. L., Hajjar, D. P., Cohen, P. A., Frazier, W. A., Hoff, H. F. & Hazen, S. L., Apr 2000, In : Journal of Clinical Investigation. 105, 8, p. 1095-1108 14 p.

Research output: Contribution to journalArticle

Open Access
330 Scopus citations

MDSC as a mechanism of tumor escape from sunitinib mediated anti-angiogenic therapy

Finke, J., Ko, J., Rini, B., Rayman, P., Ireland, J. & Cohen, P., Jul 2011, In : International Immunopharmacology. 11, 7, p. 856-861 6 p.

Research output: Contribution to journalArticle

188 Scopus citations

Mechanism of third signals provided by IL-12 and OX-40R ligation in eliciting therapeutic immunity following dendritic-tumor fusion vaccination

Kuriyama, H., Watanabe, S., Kjaergaard, J., Tamai, H., Zheng, R., Weinberg, A. D., Hu, H. M., Cohen, P. A., Plautz, G. E. & Shu, S., Dec 1 2006, In : Cellular Immunology. 243, 1, p. 30-40 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Mechanism of tumor eradication by transfer of sensitized T cells

Shu, S. & Cohen, P. A., Jan 1 2001, In : European Journal of Cancer. 37, SUPPL. 1, p. S27

Research output: Contribution to journalArticle

Memory T Cells Originate from Adoptively Transferred Effectors and Reconstituting Host Cells after Sequential Lymphodepletion and Adoptive Immunotherapy

Wang, L. X., Kjaergaard, J., Cohen, P. A., Shu, S. & Plautz, G. E., Mar 15 2004, In : Journal of Immunology. 172, 6, p. 3462-3468 7 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

MUC1 vaccines, comprised of glycosylated or non-glycosylated peptides or tumor-derived MUC1, can circumvent immunoediting to control tumor growth in MUC1 transgenic mice

Lakshminarayanan, V., Supekar, N. T., Wei, J., McCurry, D. B., Dueck, A. C., Kosiorek, H. E., Trivedi, P. P., Bradley, J. M., Madsen, C. S., Pathangey, L. B., Hoelzinger, D. B., Wolfert, M. A., Boons, G. J., Cohen, P. A. & Gendler, S. J., Jan 1 2016, In : PloS one. 11, 1, e0145920.

Research output: Contribution to journalArticle

21 Scopus citations