Panagiotis Z Anastasiadis, PhD

  • 4511 Citations
  • 30 Scopus h-Index
1990 …2020

Research output per year

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Research Output

  • 4511 Citations
  • 30 Scopus h-Index
  • 55 Article
  • 8 Review article
  • 4 Comment/debate
  • 2 Chapter

A central role for cadherin signaling in cancer

Kourtidis, A., Lu, R., Pence, L. J. & Anastasiadis, P. Z., Feb 13 2017, (Accepted/In press) In : Experimental Cell Research.

Research output: Contribution to journalArticle

67 Scopus citations

A Novel Interaction between Kinesin and p120 Modulates p120 Localization and Function

Yanagisawa, M., Kaverina, I. N., Wang, A., Fujita, Y., Reynolds, A. B. & Anastasiadis, P. Z., Mar 5 2004, In : Journal of Biological Chemistry. 279, 10, p. 9512-9521 10 p.

Research output: Contribution to journalArticle

110 Scopus citations

A novel role for p120 catenin in E-cadherin function

Ireton, R. C., Davis, M. A., Van Hengel, J., Mariner, D. J., Barnes, K., Thoreson, M. A., Anastasiadis, P. Z., Matrisian, L., Bundy, L. M., Sealy, L., Gilbert, B., Van Roy, F. & Reynolds, A. B., Nov 11 2002, In : Journal of Cell Biology. 159, 3, p. 465-476 12 p.

Research output: Contribution to journalArticle

419 Scopus citations

A p120 catenin isoform switch affects rho activity, induces tumor cell invasion, and predicts metastatic disease

Yanagisawa, M., Huveldt, D., Kreinest, P., Lohse, C. M., Cheville, J. C., Parker, A. S., Copland, J. A. & Anastasiadis, P. Z., Jun 27 2008, In : Journal of Biological Chemistry. 283, 26, p. 18344-18354 11 p.

Research output: Contribution to journalArticle

111 Scopus citations

A phase 1 and randomized, placebo-controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma: Alliance/North Central Cancer Treatment Group N0872

Galanis, E., Anderson, S. K., Twohy, E. L., Carrero, X. W., Dixon, J. G., Tran, D. D., Jeyapalan, S. A., Anderson, D. M., Kaufmann, T. J., Feathers, R. W., Giannini, C., Buckner, J. C., Anastasiadis, P. Z. & Schiff, D., Nov 1 2019, In : Cancer. 125, 21, p. 3790-3800 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Armadillo Repeat Proteins at Epithelial Adherens Junctions

Lewis-Tuffin, L. J. & Anastasiadis, P. Z., Apr 11 2008, Cell Junctions: Adhesion, Development, and Disease. Wiley-VCH Verlag GmbH & Co. KGaA, p. 151-167 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Assessment of tumor heterogeneity, as evidenced by gene expression profiles, pathway activation, and gene copy number, in patients with multifocal invasive lobular breast tumors

Norton, N., Advani, P. P., Serie, D. J., Geiger, X. J., Necela, B. M., Axenfeld, B. C., Kachergus, J. M., Feathers, R. W., Carr, J. M., Crook, J. E., Moreno-Aspitia, A., Anastasiadis, P. Z., Perez, E. A. & Thompson, E. A., Apr 2016, In : PloS one. 11, 4, e0153411.

Research output: Contribution to journalArticle

14 Scopus citations

Bringing together cell-to-cell adhesion and miRNA biology in cancer research

Kourtidis, A. & Anastasiadis, P. Z., May 1 2016, In : Future Oncology. 12, 10, p. 1211-1214 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: Common target, common therapies

Assefnia, S., Dakshanamurthy, S., Auvil, J. M. G., Hampel, C., Anastasiadis, P. Z., Kallakury, B., Uren, A., Foley, D. W., Brown, M. L., Shapiro, L., Brenner, M., Haigh, D. & Byers, S. W., 2014, In : Oncotarget. 5, 6, p. 1458-1474 17 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations

Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling

Kourtidis, A., Necela, B., Lin, W. H., Lu, R., Feathers, R. W., Asmann, Y., Thompson, E. A. & Anastasiadis, P. Z., Oct 1 2017, In : Journal of Cell Biology. 216, 10, p. 3073-3085 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cloning and characterization of genes encoding tetrahydrobiopterin biosynthetic enzymes

Levine, R. A., States, J. C., Anastasiadis, P. Z. & Kuhn, D. M., 1993, In : Advances in experimental medicine and biology. 338, p. 139-145 7 p.

Research output: Contribution to journalArticle

Close encounters of the RNAi kind: the silencing life of the adherens junctions

Kourtidis, A. & Anastasiadis, P. Z., Oct 1 2018, In : Current Opinion in Cell Biology. 54, p. 30-36 7 p.

Research output: Contribution to journalReview article

4 Scopus citations

Co-induction of tetrahydrobiopterin (BH4) levels and tyrosine hydroxylase activity in cultured PC12 cells

Anastasiadis, P. Z., States, J. C., Kuhn, D. M. & Levine, R. A., 1993, In : Advances in experimental medicine and biology. 338, p. 227-230 4 p.

Research output: Contribution to journalArticle

6 Scopus citations

Continuous association of cadherin with β-catenin requires the non-receptor tyrosine-kinase Fer

Xu, G., Craig, A. W. B., Greer, P., Miller, M., Anastasiadis, P. Z., Lilien, J. & Balsamo, J., Jul 1 2004, In : Journal of cell science. 117, 15, p. 3207-3219 13 p.

Research output: Contribution to journalReview article

109 Scopus citations

Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity

Kourtidis, A., Ngok, S. P., Pulimeno, P., Feathers, R. W., Carpio, L. R., Baker, T. R., Carr, J. M., Yan, I. K., Borges, S., Perez, E. A., Storz, P., Copland, J. A. III., Patel, T. C., Thompson, E. A., Citi, S. & Anastasiadis, P. Z., Sep 1 2015, In : Nature. 17, 9, p. 1145-1157 13 p.

Research output: Contribution to journalArticle

55 Scopus citations

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Aβ42 production

Kukar, T., Murphy, M. P., Eriksen, J. L., Sagi, S. A., Weggen, S., Smith, T. E., Ladd, T., Khan, M. A., Kache, R., Beard, J., Dodson, M., Merit, S., Ozols, V. V., Anastasiadis, P. Z., Das, P., Fauq, A., Koo, E. H. & Golde, T. E., May 1 2005, In : Nature Medicine. 11, 5, p. 545-550 6 p.

Research output: Contribution to journalArticle

246 Scopus citations

Dual regulation of Rho and Rac by p120 catenin controls adipocyte plasma membrane trafficking

Hou, J. C., Shigematsu, S., Crawford, H. C., Anastasiadis, P. Z. & Pessin, J. E., Aug 18 2006, In : Journal of Biological Chemistry. 281, 33, p. 23307-23312 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

E-cadherin's dark side: Possible role in tumor progression

Rodriguez, F. J., Lewis-Tuffin, L. J. & Anastasiadis, P. Z., Aug 1 2012, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1826, 1, p. 23-31 9 p.

Research output: Contribution to journalReview article

136 Scopus citations

Effect of Tetrahydrobiopterin on Serotonin Synthesis, Release, and Metabolism in Superfused Hippocampal Slices

Wolf, W. A., Ziaja, E., Arthur, R. A., Anastasiadis, P. Z., Levine, R. A. & Kuhn, D. M., Oct 1991, In : Journal of neurochemistry. 57, 4, p. 1191-1197 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Efficacy of the MDM2 inhibitor SAR405838 in glioblastoma is limited by poor distribution across the blood–brain barrier

Kim, M., Ma, D. J., Calligaris, D., Zhang, S., Feathers, R. W., Vaubel, R. A., Meaux, I., Mladek, A. C., Parrish, K. E., Jin, F., Barriere, C., Debussche, L., Watters, J., Tian, S., Decker, P. A., Eckel-Passow, J. E., Kitange, G. J., Johnson, A. J., Parney, I. F., Anastasiadis, P. Z. & 3 others, Agar, N. Y. R., Elmquist, W. F. & Sarkaria, J. N., Sep 1 2018, In : Molecular Cancer Therapeutics. 17, 9, p. 1893-1901 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Erratum: Vasoactive intestinal peptide induces both tyrosine hydroxylase activity and tetrahydrobiopterin biosynthesis in PC12 cells (Neuroscience (1998) 86 (179-189))

Anastasiadis, P. Z., Bezin, L., Gordon, L. J., Imerman, B., Blitz, J., Kuhn, D. M. & Levine, R. A., 1999, In : Neuroscience. 88, 2, 1 p.

Research output: Contribution to journalComment/debate

Establishment of epithelial polarity - GEF who's minding the GAP?

Ngok, S. P., Lin, W. H. & Anastasiadis, P. Z., 2014, In : Journal of cell science. 127, 15, p. 3205-3215 11 p.

Research output: Contribution to journalComment/debate

26 Scopus citations

Expression of polarity genes in human cancer

Lin, W. H., Asmann, Y. & Anastasiadis, P. Z., Mar 30 2015, In : Cancer Informatics. 14, p. 15-28 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Functional genomic analysis reveals cross-talk between peroxisome proliferator-activated receptor γ and calcium signaling in human colorectal cancer cells

Bush, C. R., Havens, J. M., Necela, B. M., Su, W., Chen, L., Yanagisawa, M., Anastasiadis, P. Z., Guerra, R., Luxon, B. A. & Thompson, E. A., Aug 10 2007, In : Journal of Biological Chemistry. 282, 32, p. 23387-23401 15 p.

Research output: Contribution to journalArticle

22 Scopus citations

Identification of Src Phosphorylation Sites in the Catenin p120 ctn

Mariner, D. J., Anastasiadis, P., Keilhack, H., Böhmer, F. D., Wang, J. & Reynolds, A. B., Jul 27 2001, In : Journal of Biological Chemistry. 276, 30, p. 28006-28013 8 p.

Research output: Contribution to journalArticle

122 Scopus citations

Influence of tetrahydrobiopterin on serotonin synthesis, metabolism and release in synaptosomes

Wolf, W. A., Anastasiadis, P. Z., Kuhn, D. M. & Levine, R. A., 1990, In : Neurochemistry International. 16, 3, p. 335-340 6 p.

Research output: Contribution to journalArticle

9 Scopus citations

Inhibition of RhoA by p120 catenin

Anastasiadis, P. Z., Moon, S. Y., Thoreson, M. A., Mariner, D. J., Crawford, H. C., Zheng, Y. & Reynolds, A. B., Sep 1 2000, In : Nature Cell Biology. 2, 9, p. 637-644 8 p.

Research output: Contribution to journalArticle

357 Scopus citations

Integration of Comprehensive Genomic Analysis and Functional Screening of Affected Molecular Pathways to Inform Cancer Therapy

Vasmatzis, G., Liu, M. C., Reganti, S., Feathers, R. W., Smadbeck, J., Johnson, S. H., Schaefer Klein, J. L., Harris, F. R., Yang, L., Kosari, F., Murphy, S. J., Borad, M. J., Thompson, E. A., Cheville, J. C. & Anastasiadis, P. Z., Feb 2020, In : Mayo Clinic proceedings. 95, 2, p. 306-318 13 p.

Research output: Contribution to journalArticle

Open Access

Misregulated E-Cadherin expression associated with an aggressive brain tumor phenotype

Lewis-Tuffin, L. J., Rodriguez, F., Giannini, C., Scheithauer, B., Necela, B. M., Sarkaria, J. N. & Anastasiadis, P. Z., 2010, In : PloS one. 5, 10, e13665.

Research output: Contribution to journalArticle

94 Scopus citations

Mitogenic Effects of Tetrahydrobiopterin: Involvement of Catecholamine and Nitric Oxide Synthesis

Anastasiadis, P. Z., Imerman, B. A., Louie, M. C., Kuhn, D. M. & Levine, R. A., Aug 1995, In : Pteridines. 6, 3, p. 132-134 3 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Mitogenic effects of tetrahydrobiopterin in PC12 cells

Anastasiadis, P. Z., States, J. C., Imerman, B. A., Louie, M. C., Kuhn, D. M. & Levine, R. A., Jan 1996, In : Molecular pharmacology. 49, 1, p. 149-155 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4

Von Roemeling, C. A., Radisky, D. C., Marlow, L. A., Cooper, S. J., Grebe, S. K., Anastasiadis, P. Z., Tun, H. W. & Copland, J. A., Sep 1 2014, In : Cancer research. 74, 17, p. 4796-4810 15 p.

Research output: Contribution to journalArticle

55 Scopus citations

Novel targeted therapy strategies for biliary tract cancers and hepatocellular carcinoma

Deleon, T. T., Ahn, D., Bogenberger, J. M., Anastasiadis, P. Z., Arora, M., Ramanathan, R. K., Aqel, B. A., Vasmatzis, G., Truty, M., Oklu, R., Bekaii-Saab, T. & Borad, M. J., Mar 1 2018, In : Future Oncology. 14, 6, p. 553-566 14 p.

Research output: Contribution to journalReview article

11 Scopus citations

P120 catenin: An essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression

Kourtidis, A., Ngok, S. P. & Anastasiadis, P. Z., Jan 1 2013, The Molecular Biology of Cadherins. Elsevier B.V., p. 409-432 24 p. (Progress in Molecular Biology and Translational Science; vol. 116).

Research output: Chapter in Book/Report/Conference proceedingChapter

85 Scopus citations

p120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression

Soto, E., Yanagisawa, M., Marlow, L. A., Copland, J. A., Perez, E. A. & Anastasiadis, P. Z., Nov 17 2008, In : Journal of Cell Biology. 183, 4, p. 737-749 13 p.

Research output: Contribution to journalArticle

76 Scopus citations

p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness

Yanagisawa, M. & Anastasiadis, P. Z., Sep 25 2006, In : Journal of Cell Biology. 174, 7, p. 1087-1096 10 p.

Research output: Contribution to journalArticle

102 Scopus citations

p120-ctn: A nexus for contextual signaling via Rho GTPases

Anastasiadis, P. Z., Jan 1 2007, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 1, p. 34-46 13 p.

Research output: Contribution to journalReview article

142 Scopus citations

Pathway signature and cellular differentiation in clear cell renal cell carcinoma

Tun, H. W., Marlow, L. A., von Roemeling, C. A., Cooper, S. J., Kreinest, P., Wu, K., Luxon, B. A., Sinha, M., Anastasiadis, P. Z. & Copland, J. A., 2010, In : PloS one. 5, 5, e10696.

Research output: Contribution to journalArticle

109 Scopus citations

Peroxisome proliferator-activated receptor γ promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2

Chen, L., Necela, B. M., Su, W., Yanagisawa, M., Anastasiadis, P. Z., Fields, A. P. & Thompson, E. A., Aug 25 2006, In : Journal of Biological Chemistry. 281, 34, p. 24575-24587 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis

Borges, S., Döppler, H., Perez, E. A., Andorfer, C. A., Sun, Z., Anastasiadis, P. Z., Thompson, E. A., Geiger, X. J. & Storz, P., Aug 23 2013, In : Breast Cancer Research. 15, 2, R66.

Research output: Contribution to journalArticle

46 Scopus citations

Phosphorylation-mediated 14-3-3 protein binding regulates the function of the rho-specific guanine nucleotide exchange factor (RhoGEF) syx

Ngok, S. P., Geyer, R., Kourtidis, A., Storz, P. & Anastasiadis, P. Z., Mar 1 2013, In : Journal of Biological Chemistry. 288, 9, p. 6640-6650 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

PLEKHA7 defines an apical junctional complex with cytoskeletal associations and miRNA-mediated growth implications

Kourtidis, A. & Anastasiadis, P. Z., Feb 16 2016, In : Cell Cycle. 15, 4, p. 498-505 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Protein kinase c (PKC) βII induces cell invasion through a Ras/Mek-, PKCι/Rac 1-dependent signaling pathway

Zhang, J., Anastasiadis, P. Z., Liu, Y., Thompson, E. A. & Fields, A. P., May 21 2004, In : Journal of Biological Chemistry. 279, 21, p. 22118-22123 6 p.

Research output: Contribution to journalArticle

117 Scopus citations

Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo

Murray, N. R., Jamieson, L., Yu, W., Zhang, J., Gökmen-Polar, Y., Sier, D., Anastasiadis, P., Gatalica, Z., Thompson, E. A. & Fields, A. P., Mar 15 2004, In : Journal of Cell Biology. 164, 6, p. 797-802 6 p.

Research output: Contribution to journalArticle

113 Scopus citations

Protein kinase D1-mediated phosphorylations regulate Vasodilator-stimulated phosphoprotein (VASP) localization and cell migration

Döppler, H. R., Bastea, L. I., Lewis-Tuffin, L. J., Anastasiadis, P. Z. & Storz, P., Aug 23 2013, In : Journal of Biological Chemistry. 288, 34, p. 24382-24393 12 p.

Research output: Contribution to journalArticle

23 Scopus citations

Pro-tumorigenic phosphorylation of p120 catenin in renal and breast cancer

Kourtidis, A., Yanagisawa, M., Huveldt, D., Copland, J. A. & Anastasiadis, P. Z., Jun 11 2015, In : PloS one. 10, 6, e0129964.

Research output: Contribution to journalArticle

9 Scopus citations

PTP-PEST targets a novel tyrosine site in p120 catenin to control epithelial cell motility and Rho GTPase activity

Espejo, R., Jeng, Y., Paulucci-Holthauzen, A., Rengifo-Cam, W., Honkus, K., Anastasiadis, P. Z. & Sastry, S. K., Feb 1 2014, In : Journal of cell science. 127, 3, p. 497-508 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Regulation of Rho GTPases by p120-catenin

Anastasiadis, P. Z. & Reynolds, A. B., Oct 1 2001, In : Current Opinion in Cell Biology. 13, 5, p. 604-610 7 p.

Research output: Contribution to journalReview article

221 Scopus citations

Regulation of tyrosine hydroxylase and tetrahydrobiopterin biosynthetic enzymes in PC12 cells by NGF, EGF and IFN-γ

Anastasiadis, P. Z., Kuhn, D. M., Blitz, J., Imerman, B. A., Louie, M. C. & Levine, R. A., Mar 25 1996, In : Brain Research. 713, 1-2, p. 125-133 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
5 Scopus citations