Panagiotis Z Anastasiadis, PhD

  • 4506 Citations
  • 30 Scopus h-Index
1990 …2020

Research output per year

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Research Output

  • 4506 Citations
  • 30 Scopus h-Index
  • 55 Article
  • 8 Review article
  • 4 Comment/debate
  • 2 Chapter
1990

Influence of tetrahydrobiopterin on serotonin synthesis, metabolism and release in synaptosomes

Wolf, W. A., Anastasiadis, P. Z., Kuhn, D. M. & Levine, R. A., 1990, In : Neurochemistry International. 16, 3, p. 335-340 6 p.

Research output: Contribution to journalArticle

9 Scopus citations
1991

Effect of Tetrahydrobiopterin on Serotonin Synthesis, Release, and Metabolism in Superfused Hippocampal Slices

Wolf, W. A., Ziaja, E., Arthur, R. A., Anastasiadis, P. Z., Levine, R. A. & Kuhn, D. M., Oct 1991, In : Journal of neurochemistry. 57, 4, p. 1191-1197 7 p.

Research output: Contribution to journalArticle

23 Scopus citations
1993

Cloning and characterization of genes encoding tetrahydrobiopterin biosynthetic enzymes

Levine, R. A., States, J. C., Anastasiadis, P. Z. & Kuhn, D. M., 1993, In : Advances in experimental medicine and biology. 338, p. 139-145 7 p.

Research output: Contribution to journalArticle

Co-induction of tetrahydrobiopterin (BH4) levels and tyrosine hydroxylase activity in cultured PC12 cells

Anastasiadis, P. Z., States, J. C., Kuhn, D. M. & Levine, R. A., 1993, In : Advances in experimental medicine and biology. 338, p. 227-230 4 p.

Research output: Contribution to journalArticle

6 Scopus citations
1994

Tetrahydrobiopterin uptake into rat brain synaptosomes, cultured PC12 cells, and rat striatum

Anastasiadis, P. Z., Kuhn, D. M. & Levine, R. A., Nov 28 1994, In : Brain Research. 665, 1, p. 77-84 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
1995

Mitogenic Effects of Tetrahydrobiopterin: Involvement of Catecholamine and Nitric Oxide Synthesis

Anastasiadis, P. Z., Imerman, B. A., Louie, M. C., Kuhn, D. M. & Levine, R. A., Aug 1995, In : Pteridines. 6, 3, p. 132-134 3 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
1996

Mitogenic effects of tetrahydrobiopterin in PC12 cells

Anastasiadis, P. Z., States, J. C., Imerman, B. A., Louie, M. C., Kuhn, D. M. & Levine, R. A., Jan 1996, In : Molecular pharmacology. 49, 1, p. 149-155 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Regulation of tyrosine hydroxylase and tetrahydrobiopterin biosynthetic enzymes in PC12 cells by NGF, EGF and IFN-γ

Anastasiadis, P. Z., Kuhn, D. M., Blitz, J., Imerman, B. A., Louie, M. C. & Levine, R. A., Mar 25 1996, In : Brain Research. 713, 1-2, p. 125-133 9 p.

Research output: Contribution to journalArticle

28 Scopus citations
1997

Tetrahydrobiopterin as a mediator of PC12 cell proliferation induced by EGF and NGF

Anastasiadis, P. Z., Bezin, L., Imerman, B. A., Kuhn, D. M., Louie, M. C. & Levine, R. A., Sep 1997, In : European Journal of Neuroscience. 9, 9, p. 1831-1837 7 p.

Research output: Contribution to journalArticle

36 Scopus citations
1998

Tetrahydrobiopterin metabolism and GTP cyclohydrolase I mutations in L-dopa-responsive dystonia.

Bezin, L., Anastasiadis, P. Z., Nygaard, T. G. & Levine, R. A., 1998, In : Advances in neurology. 78, p. 291-300 10 p.

Research output: Contribution to journalReview article

1 Scopus citations

Vasoactive intestinal peptide induces both tyrosine hydroxylase activity and tetrahydrobiopterin biosynthesis in PC12 cells

Anastasiadis, P. Z., Bezin, L., Gordon, L. J., Imerman, B., Blitz, J. & Levine, R. A., May 21 1998, In : Neuroscience. 86, 1, p. 179-189 11 p.

Research output: Contribution to journalArticle

17 Scopus citations
1999

Erratum: Vasoactive intestinal peptide induces both tyrosine hydroxylase activity and tetrahydrobiopterin biosynthesis in PC12 cells (Neuroscience (1998) 86 (179-189))

Anastasiadis, P. Z., Bezin, L., Gordon, L. J., Imerman, B., Blitz, J., Kuhn, D. M. & Levine, R. A., 1999, In : Neuroscience. 88, 2, 1 p.

Research output: Contribution to journalComment/debate

2000

Inhibition of RhoA by p120 catenin

Anastasiadis, P. Z., Moon, S. Y., Thoreson, M. A., Mariner, D. J., Crawford, H. C., Zheng, Y. & Reynolds, A. B., Sep 1 2000, In : Nature Cell Biology. 2, 9, p. 637-644 8 p.

Research output: Contribution to journalArticle

357 Scopus citations

Selective uncoupling of p120(ctn) from E-cadherin disrupts strong adhesion

Thoreson, M. A., Anastasiadis, P. Z., Daniel, J. M., Ireton, R. C., Wheelock, M. J., Johnson, K. R., Hummingbird, D. K. & Reynolds, A. B., Jan 10 2000, In : Journal of Cell Biology. 148, 1, p. 189-201 13 p.

Research output: Contribution to journalArticle

375 Scopus citations

The p120 catenin family: Complex roles in adhesion, signaling and cancer

Anastasiadis, P. Z. & Reynolds, A. B., May 16 2000, In : Journal of cell science. 113, 8, p. 1319-1334 16 p.

Research output: Contribution to journalComment/debate

364 Scopus citations
2001

Identification of Src Phosphorylation Sites in the Catenin p120 ctn

Mariner, D. J., Anastasiadis, P., Keilhack, H., Böhmer, F. D., Wang, J. & Reynolds, A. B., Jul 27 2001, In : Journal of Biological Chemistry. 276, 30, p. 28006-28013 8 p.

Research output: Contribution to journalArticle

122 Scopus citations

Regulation of Rho GTPases by p120-catenin

Anastasiadis, P. Z. & Reynolds, A. B., Oct 1 2001, In : Current Opinion in Cell Biology. 13, 5, p. 604-610 7 p.

Research output: Contribution to journalReview article

221 Scopus citations

Tetrahydrobiopterin Enhances Apoptotic PC12 Cell Death following Withdrawal of Trophic Support

Anastasiadis, P. Z., Jiang, H., Bezin, L., Kuhn, D. M. & Levine, R. A., Mar 23 2001, In : Journal of Biological Chemistry. 276, 12, p. 9050-9058 9 p.

Research output: Contribution to journalArticle

35 Scopus citations
2002

A novel role for p120 catenin in E-cadherin function

Ireton, R. C., Davis, M. A., Van Hengel, J., Mariner, D. J., Barnes, K., Thoreson, M. A., Anastasiadis, P. Z., Matrisian, L., Bundy, L. M., Sealy, L., Gilbert, B., Van Roy, F. & Reynolds, A. B., Nov 11 2002, In : Journal of Cell Biology. 159, 3, p. 465-476 12 p.

Research output: Contribution to journalArticle

419 Scopus citations
2004

A Novel Interaction between Kinesin and p120 Modulates p120 Localization and Function

Yanagisawa, M., Kaverina, I. N., Wang, A., Fujita, Y., Reynolds, A. B. & Anastasiadis, P. Z., Mar 5 2004, In : Journal of Biological Chemistry. 279, 10, p. 9512-9521 10 p.

Research output: Contribution to journalArticle

110 Scopus citations

Continuous association of cadherin with β-catenin requires the non-receptor tyrosine-kinase Fer

Xu, G., Craig, A. W. B., Greer, P., Miller, M., Anastasiadis, P. Z., Lilien, J. & Balsamo, J., Jul 1 2004, In : Journal of cell science. 117, 15, p. 3207-3219 13 p.

Research output: Contribution to journalReview article

109 Scopus citations

Protein kinase c (PKC) βII induces cell invasion through a Ras/Mek-, PKCι/Rac 1-dependent signaling pathway

Zhang, J., Anastasiadis, P. Z., Liu, Y., Thompson, E. A. & Fields, A. P., May 21 2004, In : Journal of Biological Chemistry. 279, 21, p. 22118-22123 6 p.

Research output: Contribution to journalArticle

117 Scopus citations

Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo

Murray, N. R., Jamieson, L., Yu, W., Zhang, J., Gökmen-Polar, Y., Sier, D., Anastasiadis, P., Gatalica, Z., Thompson, E. A. & Fields, A. P., Mar 15 2004, In : Journal of Cell Biology. 164, 6, p. 797-802 6 p.

Research output: Contribution to journalArticle

113 Scopus citations

Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac

Fang, X., Ji, H., Kim, S. W., Park, J. I., Vaught, T. G., Anastasiadis, P. Z., Ciesiolka, M. & McCrea, P. D., Apr 12 2004, In : Journal of Cell Biology. 165, 1, p. 87-98 12 p.

Research output: Contribution to journalArticle

76 Scopus citations
2005

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Aβ42 production

Kukar, T., Murphy, M. P., Eriksen, J. L., Sagi, S. A., Weggen, S., Smith, T. E., Ladd, T., Khan, M. A., Kache, R., Beard, J., Dodson, M., Merit, S., Ozols, V. V., Anastasiadis, P. Z., Das, P., Fauq, A., Koo, E. H. & Golde, T. E., May 1 2005, In : Nature Medicine. 11, 5, p. 545-550 6 p.

Research output: Contribution to journalArticle

246 Scopus citations
2006

Dual regulation of Rho and Rac by p120 catenin controls adipocyte plasma membrane trafficking

Hou, J. C., Shigematsu, S., Crawford, H. C., Anastasiadis, P. Z. & Pessin, J. E., Aug 18 2006, In : Journal of Biological Chemistry. 281, 33, p. 23307-23312 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness

Yanagisawa, M. & Anastasiadis, P. Z., Sep 25 2006, In : Journal of Cell Biology. 174, 7, p. 1087-1096 10 p.

Research output: Contribution to journalArticle

101 Scopus citations

Peroxisome proliferator-activated receptor γ promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2

Chen, L., Necela, B. M., Su, W., Yanagisawa, M., Anastasiadis, P. Z., Fields, A. P. & Thompson, E. A., Aug 25 2006, In : Journal of Biological Chemistry. 281, 34, p. 24575-24587 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

RS5444, a novel PPARγ agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells

Chen, L., Bush, C. R., Necela, B. M., Su, W., Yanagisawa, M., Anastasiadis, P. Z., Fields, A. P. & Thompson, E. A., Jun 7 2006, In : Molecular and Cellular Endocrinology. 251, 1-2, p. 17-32 16 p.

Research output: Contribution to journalArticle

28 Scopus citations

The role of cadherins and catenins in gliomagenesis.

Barami, K., Lewis-Tuffin, L. & Anastasiadis, P. Z., 2006, In : Neurosurgical focus. 21, 4, p. E13

Research output: Contribution to journalReview article

20 Scopus citations
2007

Functional genomic analysis reveals cross-talk between peroxisome proliferator-activated receptor γ and calcium signaling in human colorectal cancer cells

Bush, C. R., Havens, J. M., Necela, B. M., Su, W., Chen, L., Yanagisawa, M., Anastasiadis, P. Z., Guerra, R., Luxon, B. A. & Thompson, E. A., Aug 10 2007, In : Journal of Biological Chemistry. 282, 32, p. 23387-23401 15 p.

Research output: Contribution to journalArticle

22 Scopus citations

p120-ctn: A nexus for contextual signaling via Rho GTPases

Anastasiadis, P. Z., Jan 1 2007, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 1, p. 34-46 13 p.

Research output: Contribution to journalReview article

142 Scopus citations
2008

A p120 catenin isoform switch affects rho activity, induces tumor cell invasion, and predicts metastatic disease

Yanagisawa, M., Huveldt, D., Kreinest, P., Lohse, C. M., Cheville, J. C., Parker, A. S., Copland, J. A. & Anastasiadis, P. Z., Jun 27 2008, In : Journal of Biological Chemistry. 283, 26, p. 18344-18354 11 p.

Research output: Contribution to journalArticle

111 Scopus citations

Armadillo Repeat Proteins at Epithelial Adherens Junctions

Lewis-Tuffin, L. J. & Anastasiadis, P. Z., Apr 11 2008, Cell Junctions: Adhesion, Development, and Disease. Wiley-VCH Verlag GmbH & Co. KGaA, p. 151-167 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

p120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression

Soto, E., Yanagisawa, M., Marlow, L. A., Copland, J. A., Perez, E. A. & Anastasiadis, P. Z., Nov 17 2008, In : Journal of Cell Biology. 183, 4, p. 737-749 13 p.

Research output: Contribution to journalArticle

76 Scopus citations

Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and β-catenin

Lee, S. H., Peng, I. F., Ng, Y. G., Yanagisawa, M., Bamji, S. X., Elia, L. P., Balsamo, J., Lilien, J., Anastasiadis, P. Z., Ullian, E. M. & Reichardt, L. F., Dec 1 2008, In : Journal of Cell Biology. 183, 5, p. 893-908 16 p.

Research output: Contribution to journalArticle

33 Scopus citations
2010

Misregulated E-Cadherin expression associated with an aggressive brain tumor phenotype

Lewis-Tuffin, L. J., Rodriguez, F., Giannini, C., Scheithauer, B., Necela, B. M., Sarkaria, J. N. & Anastasiadis, P. Z., 2010, In : PloS one. 5, 10, e13665.

Research output: Contribution to journalArticle

94 Scopus citations

Pathway signature and cellular differentiation in clear cell renal cell carcinoma

Tun, H. W., Marlow, L. A., von Roemeling, C. A., Cooper, S. J., Kreinest, P., Wu, K., Luxon, B. A., Sinha, M., Anastasiadis, P. Z. & Copland, J. A., 2010, In : PloS one. 5, 5, e10696.

Research output: Contribution to journalArticle

109 Scopus citations

The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin

Orlichenko, L., Geyer, R., Yanagisawa, M., Khauv, D., Radisky, E. S., Anastasiadis, P. Z. & Radisky, D. C., Jun 18 2010, In : Journal of Biological Chemistry. 285, 25, p. 19153-19161 9 p.

Research output: Contribution to journalArticle

25 Scopus citations
2012

E-cadherin's dark side: Possible role in tumor progression

Rodriguez, F. J., Lewis-Tuffin, L. J. & Anastasiadis, P. Z., Aug 1 2012, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1826, 1, p. 23-31 9 p.

Research output: Contribution to journalReview article

135 Scopus citations

VEGF and angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx

Ngok, S. P., Geyer, R., Liu, M., Kourtidis, A., Agrawal, S., Wu, C., Seerapu, H. R., Lewis-Tuffin, L. J., Moodie, K. L., Huveldt, D., Marx, R., Baraban, J. M., Storz, P., Horowitz, A. & Anastasiadis, P. Z., Dec 2012, In : Journal of Cell Biology. 199, 7, p. 1103-1115 13 p.

Research output: Contribution to journalArticle

62 Scopus citations
2013

P120 catenin: An essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression

Kourtidis, A., Ngok, S. P. & Anastasiadis, P. Z., Jan 1 2013, The Molecular Biology of Cadherins. Elsevier B.V., p. 409-432 24 p. (Progress in Molecular Biology and Translational Science; vol. 116).

Research output: Chapter in Book/Report/Conference proceedingChapter

85 Scopus citations

Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis

Borges, S., Döppler, H., Perez, E. A., Andorfer, C. A., Sun, Z., Anastasiadis, P. Z., Thompson, E. A., Geiger, X. J. & Storz, P., Aug 23 2013, In : Breast Cancer Research. 15, 2, R66.

Research output: Contribution to journalArticle

46 Scopus citations

Phosphorylation-mediated 14-3-3 protein binding regulates the function of the rho-specific guanine nucleotide exchange factor (RhoGEF) syx

Ngok, S. P., Geyer, R., Kourtidis, A., Storz, P. & Anastasiadis, P. Z., Mar 1 2013, In : Journal of Biological Chemistry. 288, 9, p. 6640-6650 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Protein kinase D1-mediated phosphorylations regulate Vasodilator-stimulated phosphoprotein (VASP) localization and cell migration

Döppler, H. R., Bastea, L. I., Lewis-Tuffin, L. J., Anastasiadis, P. Z. & Storz, P., Aug 23 2013, In : Journal of Biological Chemistry. 288, 34, p. 24382-24393 12 p.

Research output: Contribution to journalArticle

22 Scopus citations
5 Scopus citations

Targeting Src Family Kinases Inhibits Bevacizumab-Induced Glioma Cell Invasion

Huveldt, D., Lewis-Tuffin, L. J., Carlson, B. L., Schroeder, M. A., Rodriguez, F., Giannini, C., Galanis, E., Sarkaria, J. N. & Anastasiadis, P. Z., Feb 14 2013, In : PloS one. 8, 2, e56505.

Research output: Contribution to journalArticle

54 Scopus citations

TEM4 is a junctional Rho GEF required for cell-cell adhesion, monolayer integrity and barrier function

Ngok, S. P., Geyer, R., Kourtidis, A., Mitin, N., Feathers, R., Der, C. & Anastasiadis, P. Z., Sep 9 2013, In : Journal of cell science. 126, 15, p. 3271-3277 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

The Rho guanine nucleotide exchange factor Syx regulates the balance of dia and ROCK activities to promote polarized-cancer-cell migration

Dachsel, J. C., Ngok, S. P., Lewis-Tuffin, L. J., Kourtidis, A., Geyer, R., Johnston, L., Feathers, R. & Anastasiadis, P. Z., Dec 2013, In : Molecular and cellular biology. 33, 24, p. 4909-4918 10 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
2014

Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: Common target, common therapies

Assefnia, S., Dakshanamurthy, S., Auvil, J. M. G., Hampel, C., Anastasiadis, P. Z., Kallakury, B., Uren, A., Foley, D. W., Brown, M. L., Shapiro, L., Brenner, M., Haigh, D. & Byers, S. W., 2014, In : Oncotarget. 5, 6, p. 1458-1474 17 p.

Research output: Contribution to journalArticle

Open Access
30 Scopus citations