Panagiotis Z Anastasiadis, PhD

  • 4492 Citations
  • 30 Scopus h-Index
1990 …2020

Research output per year

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Research Output

  • 4492 Citations
  • 30 Scopus h-Index
  • 55 Article
  • 8 Review article
  • 4 Comment/debate
  • 2 Chapter
2020

Integration of Comprehensive Genomic Analysis and Functional Screening of Affected Molecular Pathways to Inform Cancer Therapy

Vasmatzis, G., Liu, M. C., Reganti, S., Feathers, R. W., Smadbeck, J., Johnson, S. H., Schaefer Klein, J. L., Harris, F. R., Yang, L., Kosari, F., Murphy, S. J., Borad, M. J., Thompson, E. A., Cheville, J. C. & Anastasiadis, P. Z., Feb 2020, In : Mayo Clinic proceedings. 95, 2, p. 306-318 13 p.

Research output: Contribution to journalArticle

Open Access
2019

A phase 1 and randomized, placebo-controlled phase 2 trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma: Alliance/North Central Cancer Treatment Group N0872

Galanis, E., Anderson, S. K., Twohy, E. L., Carrero, X. W., Dixon, J. G., Tran, D. D., Jeyapalan, S. A., Anderson, D. M., Kaufmann, T. J., Feathers, R. W., Giannini, C., Buckner, J. C., Anastasiadis, P. Z. & Schiff, D., Nov 1 2019, In : Cancer. 125, 21, p. 3790-3800 11 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Close encounters of the RNAi kind: the silencing life of the adherens junctions

Kourtidis, A. & Anastasiadis, P. Z., Oct 1 2018, In : Current Opinion in Cell Biology. 54, p. 30-36 7 p.

Research output: Contribution to journalReview article

4 Scopus citations

Efficacy of the MDM2 inhibitor SAR405838 in glioblastoma is limited by poor distribution across the blood–brain barrier

Kim, M., Ma, D. J., Calligaris, D., Zhang, S., Feathers, R. W., Vaubel, R. A., Meaux, I., Mladek, A. C., Parrish, K. E., Jin, F., Barriere, C., Debussche, L., Watters, J., Tian, S., Decker, P. A., Eckel-Passow, J. E., Kitange, G. J., Johnson, A. J., Parney, I. F., Anastasiadis, P. Z. & 3 others, Agar, N. Y. R., Elmquist, W. F. & Sarkaria, J. N., Sep 1 2018, In : Molecular Cancer Therapeutics. 17, 9, p. 1893-1901 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Novel targeted therapy strategies for biliary tract cancers and hepatocellular carcinoma

Deleon, T. T., Ahn, D., Bogenberger, J. M., Anastasiadis, P. Z., Arora, M., Ramanathan, R. K., Aqel, B. A., Vasmatzis, G., Truty, M., Oklu, R., Bekaii-Saab, T. & Borad, M. J., Mar 1 2018, In : Future Oncology. 14, 6, p. 553-566 14 p.

Research output: Contribution to journalReview article

11 Scopus citations

Simultaneous E-cadherin and PLEKHA7 expression negatively affects E-cadherin/EGFR mediated ovarian cancer cell growth

Rea, K., Roggiani, F., De Cecco, L., Raspagliesi, F., Carcangiu, M. L., Nair-Menon, J., Bagnoli, M., Bortolomai, I., Mezzanzanica, D., Canevari, S., Kourtidis, A., Anastasiadis, P. Z. & Tomassetti, A., Jul 11 2018, In : Journal of Experimental and Clinical Cancer Research. 37, 1, 146.

Research output: Contribution to journalArticle

5 Scopus citations
2017

A central role for cadherin signaling in cancer

Kourtidis, A., Lu, R., Pence, L. J. & Anastasiadis, P. Z., Feb 13 2017, (Accepted/In press) In : Experimental Cell Research.

Research output: Contribution to journalArticle

64 Scopus citations

Cadherin complexes recruit mRNAs and RISC to regulate epithelial cell signaling

Kourtidis, A., Necela, B., Lin, W. H., Lu, R., Feathers, R. W., Asmann, Y., Thompson, E. A. & Anastasiadis, P. Z., Oct 1 2017, In : Journal of Cell Biology. 216, 10, p. 3073-3085 13 p.

Research output: Contribution to journalArticle

11 Scopus citations
2016

Assessment of tumor heterogeneity, as evidenced by gene expression profiles, pathway activation, and gene copy number, in patients with multifocal invasive lobular breast tumors

Norton, N., Advani, P. P., Serie, D. J., Geiger, X. J., Necela, B. M., Axenfeld, B. C., Kachergus, J. M., Feathers, R. W., Carr, J. M., Crook, J. E., Moreno-Aspitia, A., Anastasiadis, P. Z., Perez, E. A. & Thompson, E. A., Apr 2016, In : PloS one. 11, 4, e0153411.

Research output: Contribution to journalArticle

14 Scopus citations

Bringing together cell-to-cell adhesion and miRNA biology in cancer research

Kourtidis, A. & Anastasiadis, P. Z., May 1 2016, In : Future Oncology. 12, 10, p. 1211-1214 4 p.

Research output: Contribution to journalArticle

5 Scopus citations

PLEKHA7 defines an apical junctional complex with cytoskeletal associations and miRNA-mediated growth implications

Kourtidis, A. & Anastasiadis, P. Z., Feb 16 2016, In : Cell Cycle. 15, 4, p. 498-505 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

The cystic fibrosis transmembrane conductance regulator controls biliary epithelial inflammation and permeability by regulating Src tyrosine kinase activity

Fiorotto, R., Villani, A., Kourtidis, A., Scirpo, R., Amenduni, M., Geibel, P. J., Cadamuro, M., Spirli, C., Anastasiadis, P. Z. & Strazzabosco, M., Dec 1 2016, In : Hepatology. 64, 6, p. 2118-2134 17 p.

Research output: Contribution to journalArticle

27 Scopus citations
2015

Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity

Kourtidis, A., Ngok, S. P., Pulimeno, P., Feathers, R. W., Carpio, L. R., Baker, T. R., Carr, J. M., Yan, I. K., Borges, S., Perez, E. A., Storz, P., Copland, J. A. III., Patel, T. C., Thompson, E. A., Citi, S. & Anastasiadis, P. Z., Sep 1 2015, In : Nature. 17, 9, p. 1145-1157 13 p.

Research output: Contribution to journalArticle

55 Scopus citations

Expression of polarity genes in human cancer

Lin, W. H., Asmann, Y. & Anastasiadis, P. Z., Mar 30 2015, In : Cancer Informatics. 14, p. 15-28 14 p.

Research output: Contribution to journalArticle

11 Scopus citations

Pro-tumorigenic phosphorylation of p120 catenin in renal and breast cancer

Kourtidis, A., Yanagisawa, M., Huveldt, D., Copland, J. A. & Anastasiadis, P. Z., Jun 11 2015, In : PloS one. 10, 6, e0129964.

Research output: Contribution to journalArticle

9 Scopus citations

Src family kinases differentially influence glioma growth and motility

Lewis-Tuffin, L. J., Feathers, R., Hari, P., Durand, N., Li, Z., Rodriguez, F. J., Bakken, K., Carlson, B., Schroeder, M., Sarkaria, J. N. & Anastasiadis, P. Z., Nov 1 2015, In : Molecular Oncology. 9, 9, p. 1783-1798 16 p.

Research output: Contribution to journalArticle

23 Scopus citations
2014

Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: Common target, common therapies

Assefnia, S., Dakshanamurthy, S., Auvil, J. M. G., Hampel, C., Anastasiadis, P. Z., Kallakury, B., Uren, A., Foley, D. W., Brown, M. L., Shapiro, L., Brenner, M., Haigh, D. & Byers, S. W., 2014, In : Oncotarget. 5, 6, p. 1458-1474 17 p.

Research output: Contribution to journalArticle

Open Access
29 Scopus citations

Establishment of epithelial polarity - GEF who's minding the GAP?

Ngok, S. P., Lin, W. H. & Anastasiadis, P. Z., 2014, In : Journal of cell science. 127, 15, p. 3205-3215 11 p.

Research output: Contribution to journalComment/debate

26 Scopus citations

Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4

Von Roemeling, C. A., Radisky, D. C., Marlow, L. A., Cooper, S. J., Grebe, S. K., Anastasiadis, P. Z., Tun, H. W. & Copland, J. A., Sep 1 2014, In : Cancer research. 74, 17, p. 4796-4810 15 p.

Research output: Contribution to journalArticle

54 Scopus citations

PTP-PEST targets a novel tyrosine site in p120 catenin to control epithelial cell motility and Rho GTPase activity

Espejo, R., Jeng, Y., Paulucci-Holthauzen, A., Rengifo-Cam, W., Honkus, K., Anastasiadis, P. Z. & Sastry, S. K., Feb 1 2014, In : Journal of cell science. 127, 3, p. 497-508 12 p.

Research output: Contribution to journalArticle

9 Scopus citations
2013

P120 catenin: An essential regulator of cadherin stability, adhesion-induced signaling, and cancer progression

Kourtidis, A., Ngok, S. P. & Anastasiadis, P. Z., Jan 1 2013, The Molecular Biology of Cadherins. Elsevier B.V., p. 409-432 24 p. (Progress in Molecular Biology and Translational Science; vol. 116).

Research output: Chapter in Book/Report/Conference proceedingChapter

84 Scopus citations

Pharmacologic reversion of epigenetic silencing of the PRKD1 promoter blocks breast tumor cell invasion and metastasis

Borges, S., Döppler, H., Perez, E. A., Andorfer, C. A., Sun, Z., Anastasiadis, P. Z., Thompson, E. A., Geiger, X. J. & Storz, P., Aug 23 2013, In : Breast Cancer Research. 15, 2, R66.

Research output: Contribution to journalArticle

46 Scopus citations

Phosphorylation-mediated 14-3-3 protein binding regulates the function of the rho-specific guanine nucleotide exchange factor (RhoGEF) syx

Ngok, S. P., Geyer, R., Kourtidis, A., Storz, P. & Anastasiadis, P. Z., Mar 1 2013, In : Journal of Biological Chemistry. 288, 9, p. 6640-6650 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Protein kinase D1-mediated phosphorylations regulate Vasodilator-stimulated phosphoprotein (VASP) localization and cell migration

Döppler, H. R., Bastea, L. I., Lewis-Tuffin, L. J., Anastasiadis, P. Z. & Storz, P., Aug 23 2013, In : Journal of Biological Chemistry. 288, 34, p. 24382-24393 12 p.

Research output: Contribution to journalArticle

22 Scopus citations
5 Scopus citations

Targeting Src Family Kinases Inhibits Bevacizumab-Induced Glioma Cell Invasion

Huveldt, D., Lewis-Tuffin, L. J., Carlson, B. L., Schroeder, M. A., Rodriguez, F., Giannini, C., Galanis, E., Sarkaria, J. N. & Anastasiadis, P. Z., Feb 14 2013, In : PloS one. 8, 2, e56505.

Research output: Contribution to journalArticle

52 Scopus citations

TEM4 is a junctional Rho GEF required for cell-cell adhesion, monolayer integrity and barrier function

Ngok, S. P., Geyer, R., Kourtidis, A., Mitin, N., Feathers, R., Der, C. & Anastasiadis, P. Z., Sep 9 2013, In : Journal of cell science. 126, 15, p. 3271-3277 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

The Rho guanine nucleotide exchange factor Syx regulates the balance of dia and ROCK activities to promote polarized-cancer-cell migration

Dachsel, J. C., Ngok, S. P., Lewis-Tuffin, L. J., Kourtidis, A., Geyer, R., Johnston, L., Feathers, R. & Anastasiadis, P. Z., Dec 2013, In : Molecular and cellular biology. 33, 24, p. 4909-4918 10 p.

Research output: Contribution to journalArticle

Open Access
18 Scopus citations
2012

E-cadherin's dark side: Possible role in tumor progression

Rodriguez, F. J., Lewis-Tuffin, L. J. & Anastasiadis, P. Z., Aug 1 2012, In : Biochimica et Biophysica Acta - Reviews on Cancer. 1826, 1, p. 23-31 9 p.

Research output: Contribution to journalReview article

135 Scopus citations

VEGF and angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx

Ngok, S. P., Geyer, R., Liu, M., Kourtidis, A., Agrawal, S., Wu, C., Seerapu, H. R., Lewis-Tuffin, L. J., Moodie, K. L., Huveldt, D., Marx, R., Baraban, J. M., Storz, P., Horowitz, A. & Anastasiadis, P. Z., Dec 2012, In : Journal of Cell Biology. 199, 7, p. 1103-1115 13 p.

Research output: Contribution to journalArticle

61 Scopus citations
2010

Misregulated E-Cadherin expression associated with an aggressive brain tumor phenotype

Lewis-Tuffin, L. J., Rodriguez, F., Giannini, C., Scheithauer, B., Necela, B. M., Sarkaria, J. N. & Anastasiadis, P. Z., 2010, In : PloS one. 5, 10, e13665.

Research output: Contribution to journalArticle

94 Scopus citations

Pathway signature and cellular differentiation in clear cell renal cell carcinoma

Tun, H. W., Marlow, L. A., von Roemeling, C. A., Cooper, S. J., Kreinest, P., Wu, K., Luxon, B. A., Sinha, M., Anastasiadis, P. Z. & Copland, J. A., Sep 17 2010, In : PloS one. 5, 5, e10696.

Research output: Contribution to journalArticle

108 Scopus citations

The 19-amino acid insertion in the tumor-associated splice isoform Rac1b confers specific binding to p120 catenin

Orlichenko, L., Geyer, R., Yanagisawa, M., Khauv, D., Radisky, E. S., Anastasiadis, P. Z. & Radisky, D. C., Jun 18 2010, In : Journal of Biological Chemistry. 285, 25, p. 19153-19161 9 p.

Research output: Contribution to journalArticle

25 Scopus citations
2008

A p120 catenin isoform switch affects rho activity, induces tumor cell invasion, and predicts metastatic disease

Yanagisawa, M., Huveldt, D., Kreinest, P., Lohse, C. M., Cheville, J. C., Parker, A. S., Copland, J. A. & Anastasiadis, P. Z., Jun 27 2008, In : Journal of Biological Chemistry. 283, 26, p. 18344-18354 11 p.

Research output: Contribution to journalArticle

111 Scopus citations

Armadillo Repeat Proteins at Epithelial Adherens Junctions

Lewis-Tuffin, L. J. & Anastasiadis, P. Z., Apr 11 2008, Cell Junctions: Adhesion, Development, and Disease. Wiley-VCH Verlag GmbH & Co. KGaA, p. 151-167 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

p120 catenin induces opposing effects on tumor cell growth depending on E-cadherin expression

Soto, E., Yanagisawa, M., Marlow, L. A., Copland, J. A., Perez, E. A. & Anastasiadis, P. Z., Nov 17 2008, In : Journal of Cell Biology. 183, 4, p. 737-749 13 p.

Research output: Contribution to journalArticle

76 Scopus citations

Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and β-catenin

Lee, S. H., Peng, I. F., Ng, Y. G., Yanagisawa, M., Bamji, S. X., Elia, L. P., Balsamo, J., Lilien, J., Anastasiadis, P. Z., Ullian, E. M. & Reichardt, L. F., Dec 1 2008, In : Journal of Cell Biology. 183, 5, p. 893-908 16 p.

Research output: Contribution to journalArticle

33 Scopus citations
2007

Functional genomic analysis reveals cross-talk between peroxisome proliferator-activated receptor γ and calcium signaling in human colorectal cancer cells

Bush, C. R., Havens, J. M., Necela, B. M., Su, W., Chen, L., Yanagisawa, M., Anastasiadis, P. Z., Guerra, R., Luxon, B. A. & Thompson, E. A., Aug 10 2007, In : Journal of Biological Chemistry. 282, 32, p. 23387-23401 15 p.

Research output: Contribution to journalArticle

22 Scopus citations

p120-ctn: A nexus for contextual signaling via Rho GTPases

Anastasiadis, P. Z., Jan 1 2007, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 1, p. 34-46 13 p.

Research output: Contribution to journalReview article

142 Scopus citations
2006

Dual regulation of Rho and Rac by p120 catenin controls adipocyte plasma membrane trafficking

Hou, J. C., Shigematsu, S., Crawford, H. C., Anastasiadis, P. Z. & Pessin, J. E., Aug 18 2006, In : Journal of Biological Chemistry. 281, 33, p. 23307-23312 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

p120 catenin is essential for mesenchymal cadherin-mediated regulation of cell motility and invasiveness

Yanagisawa, M. & Anastasiadis, P. Z., Sep 25 2006, In : Journal of Cell Biology. 174, 7, p. 1087-1096 10 p.

Research output: Contribution to journalArticle

101 Scopus citations

Peroxisome proliferator-activated receptor γ promotes epithelial to mesenchymal transformation by Rho GTPase-dependent activation of ERK1/2

Chen, L., Necela, B. M., Su, W., Yanagisawa, M., Anastasiadis, P. Z., Fields, A. P. & Thompson, E. A., Aug 25 2006, In : Journal of Biological Chemistry. 281, 34, p. 24575-24587 13 p.

Research output: Contribution to journalArticle

46 Scopus citations

RS5444, a novel PPARγ agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells

Chen, L., Bush, C. R., Necela, B. M., Su, W., Yanagisawa, M., Anastasiadis, P. Z., Fields, A. P. & Thompson, E. A., Jun 7 2006, In : Molecular and Cellular Endocrinology. 251, 1-2, p. 17-32 16 p.

Research output: Contribution to journalArticle

28 Scopus citations

The role of cadherins and catenins in gliomagenesis.

Barami, K., Lewis-Tuffin, L. & Anastasiadis, P. Z., 2006, In : Neurosurgical focus. 21, 4, p. E13

Research output: Contribution to journalReview article

20 Scopus citations
2005

Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Aβ42 production

Kukar, T., Murphy, M. P., Eriksen, J. L., Sagi, S. A., Weggen, S., Smith, T. E., Ladd, T., Khan, M. A., Kache, R., Beard, J., Dodson, M., Merit, S., Ozols, V. V., Anastasiadis, P. Z., Das, P., Fauq, A., Koo, E. H. & Golde, T. E., May 1 2005, In : Nature Medicine. 11, 5, p. 545-550 6 p.

Research output: Contribution to journalArticle

246 Scopus citations
2004

A Novel Interaction between Kinesin and p120 Modulates p120 Localization and Function

Yanagisawa, M., Kaverina, I. N., Wang, A., Fujita, Y., Reynolds, A. B. & Anastasiadis, P. Z., Mar 5 2004, In : Journal of Biological Chemistry. 279, 10, p. 9512-9521 10 p.

Research output: Contribution to journalArticle

110 Scopus citations

Continuous association of cadherin with β-catenin requires the non-receptor tyrosine-kinase Fer

Xu, G., Craig, A. W. B., Greer, P., Miller, M., Anastasiadis, P. Z., Lilien, J. & Balsamo, J., Jul 1 2004, In : Journal of cell science. 117, 15, p. 3207-3219 13 p.

Research output: Contribution to journalReview article

109 Scopus citations

Protein kinase c (PKC) βII induces cell invasion through a Ras/Mek-, PKCι/Rac 1-dependent signaling pathway

Zhang, J., Anastasiadis, P. Z., Liu, Y., Thompson, E. A. & Fields, A. P., May 21 2004, In : Journal of Biological Chemistry. 279, 21, p. 22118-22123 6 p.

Research output: Contribution to journalArticle

117 Scopus citations

Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo

Murray, N. R., Jamieson, L., Yu, W., Zhang, J., Gökmen-Polar, Y., Sier, D., Anastasiadis, P., Gatalica, Z., Thompson, E. A. & Fields, A. P., Mar 15 2004, In : Journal of Cell Biology. 164, 6, p. 797-802 6 p.

Research output: Contribution to journalArticle

113 Scopus citations

Vertebrate development requires ARVCF and p120 catenins and their interplay with RhoA and Rac

Fang, X., Ji, H., Kim, S. W., Park, J. I., Vaught, T. G., Anastasiadis, P. Z., Ciesiolka, M. & McCrea, P. D., Apr 12 2004, In : Journal of Cell Biology. 165, 1, p. 87-98 12 p.

Research output: Contribution to journalArticle

76 Scopus citations