Nicole R Murray, PhD

  • 2793 Citations
  • 29 Scopus h-Index
1989 …2020

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2020

Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in Lung Squamous Cell Carcinoma

Liu, Y., Yin, N., Wang, X., Khoor, A., Sambandam, V., Ghosh, A. B., Fields, Z. A., Murray, N. R., Justilien, V. & Fields, A. P., Jan 21 2020, In : Cell reports. 30, 3, p. 771-782.e6

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
1 Scopus citations

Protein kinase Cι promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of non-small-cell lung cancer cells

Justilien, V., Lewis, K. C., Meneses, K. M., Jamieson, L., Murray, N. R. & Fields, A. P., Jun 12 2020, In : The Journal of biological chemistry. 295, 24, p. 8214-8226 13 p.

Research output: Contribution to journalArticle

2019

Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC

Justilien, V., Lewis, K. C., Murray, N. R. & Fields, A. P., Sep 3 2019, In : Small GTPases. 10, 5, p. 388-394 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma

Yin, N., Liu, Y., Khoor, A., Wang, X., Thompson, E. A., Leitges, M., Justilien, V., Weems, C., Murray, N. R. & Fields, A. P., Aug 12 2019, In : Cancer cell. 36, 2, p. 156-167.e7

Research output: Contribution to journalArticle

4 Scopus citations
2018

Protein kinase Cι: A versatile oncogene in the lung

Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Oncology. e1190886.

Research output: Contribution to journalArticle

2017

Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma

Justilien, V., Ali, S. A., Jamieson, L., Yin, N., Cox, A. D., Der, C. J., Murray, N. R. & Fields, A. P., Feb 13 2017, In : Cancer Cell. 31, 2, p. 256-269 14 p.

Research output: Contribution to journalArticle

47 Scopus citations
2016

PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis

Wang, Y., Justilien, V., Brennan, K. I., Jamieson, L., Murray, N. R. & Fields, A. P., Jun 20 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

21 Scopus citations

Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma

Ali, S. A., Justilien, V., Jamieson, L., Murray, N. R. & Fields, A. P., Mar 14 2016, In : Cancer Cell. 29, 3, p. 367-378 12 p.

Research output: Contribution to journalArticle

41 Scopus citations

Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC

Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jun 30 2016, (Accepted/In press) In : Small GTPases. p. 1-7 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

The chromosome 3q26 OncCassette: A multigenic driver of human cancer

Fields, A. P., Justilien, V. & Murray, N. R., Jan 1 2016, In : Advances in Biological Regulation. 60, p. 47-63 17 p.

Research output: Contribution to journalArticle

28 Scopus citations
2015

A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion

Butler, A. M., Scotti Buzhardt, M. L., Erdogan, E., Li, S., Inman, K. S., Fields, A. P. & Murray, N. R., 2015, In : Oncotarget. 6, 17, p. 15297-15310 14 p.

Research output: Contribution to journalArticle

Open Access
21 Scopus citations

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia

Liou, G. Y., Döppler, H., Braun, U. B., Panayiotou, R., Scotti Buzhardt, M., Radisky, D. C., Crawford, H. C., Fields, A. P., Murray, N. R., Wang, Q. J., Leitges, M. & Storz, P., Feb 20 2015, In : Nature communications. 6, 6200.

Research output: Contribution to journalArticle

36 Scopus citations
2014

Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis

Hill, K. S., Erdogan, E., Khoor, A., Walsh, M. P., Leitges, M., Murray, N. R. & Fields, A. P., Apr 17 2014, In : Oncogene. 33, 16, p. 2134-2144 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma

Justilien, V., Walsh, M. P., Ali, S. A., Thompson, E. A., Murray, N. R. & Fields, A. P., Feb 10 2014, In : Cancer cell. 25, 2, p. 139-151 13 p.

Research output: Contribution to journalArticle

173 Scopus citations
2013

Protein Kinase C Zeta Regulates Human Pancreatic Cancer Cell Transformed Growth and Invasion through a STAT3-Dependent Mechanism

Butler, A. M., Scotti Buzhardt, M. L., Li, S., Smith, K. E., Fields, A. P. & Murray, N. R., Aug 28 2013, In : PloS one. 8, 8, e72061.

Research output: Contribution to journalArticle

24 Scopus citations
2012

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

Ardito, C. M., Grüner, B. M., Takeuchi, K. K., Lubeseder-Martellato, C., Teichmann, N., Mazur, P. K., DelGiorno, K. E., Carpenter, E. S., Halbrook, C. J., Hall, J. C., Pal, D., Briel, T., Herner, A., Trajkovic-Arsic, M., Sipos, B., Liou, G. Y., Storz, P., Murray, N. R., Threadgill, D. W., Sibilia, M. & 6 others, Washington, M. K., Wilson, C. L., Schmid, R. M., Raines, E. W., Crawford, H. C. & Siveke, J. T., Sep 11 2012, In : Cancer cell. 22, 3, p. 304-317 14 p.

Research output: Contribution to journalArticle

291 Scopus citations

Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential

Justilien, V., Regala, R. P., Tseng, I. C., Walsh, M. P., Batra, J., Radisky, E. S., Murray, N. R. & Fields, A. P., Apr 24 2012, In : PloS one. 7, 4, e35040.

Research output: Contribution to journalArticle

61 Scopus citations

Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia

Scotti, M. L., Smith, K. E., Butler, A. M., Calcagno, S. R., Crawford, H. C., Leitges, M., Fields, A. P. & Murray, N. R., Feb 16 2012, In : PloS one. 7, 2, e30509.

Research output: Contribution to journalArticle

11 Scopus citations
2011

Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation

Regala, R. P., Justilien, V., Walsh, M. P., Weems, C., Khoor, A., Murray, N. R. & Fields, A. P., Oct 17 2011, In : PloS one. 6, 10, e26439.

Research output: Contribution to journalArticle

24 Scopus citations

Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis

Calcagno, S. R., Li, S., Shahid, M. W., Wallace, M. B., Leitges, M., Fields, A. P. & Murray, N. R., Aug 1 2011, In : Inflammatory bowel diseases. 17, 8, p. 1685-1697 13 p.

Research output: Contribution to journalArticle

13 Scopus citations
2010

Protein kinase Cι is required for pancreatic cancer cell transformed growth and tumorigenesis

Scotti, M. L., Bamlet, W. R., Smyrk, T. C., Fields, A. P. & Murray, N. R., Mar 1 2010, In : Cancer research. 70, 5, p. 2064-2074 11 p.

Research output: Contribution to journalArticle

63 Scopus citations
2009

Protein kinase C βII and PKCι/λ: Collaborating partners in colon cancer promotion and progression

Murray, N. R., Weems, J., Braun, U., Leitges, M. & Fields, A. P., Jan 15 2009, In : Cancer research. 69, 2, p. 656-662 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Protein kinase cβ is an effective target for chemoprevention of colon cancer

Fields, A. P., Calcagno, S. R., Krishna, M., Rak, S., Leitges, M. & Murray, N. R., Feb 15 2009, In : Cancer research. 69, 4, p. 1643-1650 8 p.

Research output: Contribution to journalArticle

19 Scopus citations
2008

Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon

Calcagno, S. R., Li, S., Colon, M., Kreinest, P. A., Thompson, E. A., Fields, A. P. & Murray, N. R., Jun 1 2008, In : International Journal of Cancer. 122, 11, p. 2462-2470 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Protein kinase C isozymes as therapeutic targets for treatment of human cancers

Fields, A. P. & Murray, N. R., Sep 15 2008, In : Advances in Enzyme Regulation. 48, 1, p. 166-178 13 p.

Research output: Contribution to journalArticle

29 Scopus citations
12 Scopus citations
2007

Differential expression, distribution, and function of PPAR-γ in the proximal and distal colon

Su, W., Bush, C. R., Necela, B. M., Calcagno, S. R., Murray, N. R., Fields, A. P. & Thompson, E. A., Aug 20 2007, In : Physiological Genomics. 30, 3, p. 342-353 12 p.

Research output: Contribution to journalArticle

45 Scopus citations
2006

A novel small-molecule inhibitor of protein kinase Cι blocks transformed growth of non-small-cell lung cancer cells

Stailings-Mann, M., Jamieson, L., Regala, R. P., Weems, C., Murray, N. R. & Fields, A. P., Feb 1 2006, In : Cancer research. 66, 3, p. 1767-1774 8 p.

Research output: Contribution to journalArticle

123 Scopus citations
2004

Protein kinase C beta;II regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo

Liu, Y., Su, W., Thompson, E. A., Leitges, M., Murray, N. R. & Fields, A. P., Oct 29 2004, In : Journal of Biological Chemistry. 279, 44, p. 45556-45563 8 p.

Research output: Contribution to journalArticle

44 Scopus citations

Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo

Murray, N. R., Jamieson, L., Yu, W., Zhang, J., Gökmen-Polar, Y., Sier, D., Anastasiadis, P., Gatalica, Z., Thompson, E. A. & Fields, A. P., Mar 15 2004, In : Journal of Cell Biology. 164, 6, p. 797-802 6 p.

Research output: Contribution to journalArticle

113 Scopus citations
2003
7 Scopus citations

Role of cyclooxygenase 2 in protein kinase C βII-mediated colon carcinogenesis

Yu, W., Murray, N. R., Weems, C., Chen, L., Guo, H., Ethridge, R., Ceci, J. D., Evers, B. M., Thompson, E. A. & Fields, A. P., Mar 28 2003, In : Journal of Biological Chemistry. 278, 13, p. 11167-11174 8 p.

Research output: Contribution to journalArticle

67 Scopus citations
2002

Protein kinase C βII and TGFβRII in ω-3 fatty acid-mediated inhibition of colon carcinogenesis

Murray, N. R., Weems, C., Chen, L., Leon, J., Wangsheng, W., Davidson, L. A., Jamieson, L., Chapkin, R. S., Aubrey Thompson, E. & Fields, A. P., Jun 10 2002, In : Journal of Cell Biology. 157, 6, p. 915-920 6 p.

Research output: Contribution to journalArticle

61 Scopus citations
2001

Elevated protein kinase C βII is an early promotive event in colon carcinogenesis

Gökmen-Polar, Y., Murray, N. R., Velasco, M. A., Gatalica, Z. & Fields, A. P., Feb 15 2001, In : Cancer research. 61, 4, p. 1375-1381 7 p.

Research output: Contribution to journalArticle

168 Scopus citations
1999
66 Scopus citations

Overexpression of protein kinase C β(II) induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis

Murray, N. R., Davidson, L. A., Chapkin, R. S., Gustafson, W. C., Schattenberg, D. G. & Fields, A. P., May 17 1999, In : Journal of Cell Biology. 145, 4, p. 699-711 13 p.

Research output: Contribution to journalArticle

145 Scopus citations

Protein kinase Cα regulates human monocyte O2̇ production and low density lipoprotein lipid oxidation

Li, Q., Subbulakshmi, V., Fields, A. P., Murray, N. R. & Cathcart, M. K., Feb 5 1999, In : Journal of Biological Chemistry. 274, 6, p. 3764-3771 8 p.

Research output: Contribution to journalArticle

66 Scopus citations
1998

Phosphatidylglycerol is a physiologic activator of nuclear protein kinase C

Murray, N. R. & Fields, A. P., May 8 1998, In : Journal of Biological Chemistry. 273, 19, p. 11514-11520 7 p.

Research output: Contribution to journalArticle

62 Scopus citations
1997

A role for nuclear phosphatidylinositol-specific phospholipase C in the G2/M phase transition

Sun, B., Murray, N. R. & Fields, A. P., Oct 17 1997, In : Journal of Biological Chemistry. 272, 42, p. 26313-26317 5 p.

Research output: Contribution to journalArticle

104 Scopus citations

Atypical protein kinase C ι protects human leukemia cells against drug- induced apoptosis

Murray, N. R. & Fields, A. P., Oct 31 1997, In : Journal of Biological Chemistry. 272, 44, p. 27521-27524 4 p.

Research output: Contribution to journalArticle

151 Scopus citations
1996

The PKC agonist bryostatjn 1 stimulates developmental hematopoies1s in embryonic stem (ES) cells

Kalma, G. D., Smith, O. M., Murray, N., Carr, B., Field, A. & May, W. S., Dec 1 1996, In : Experimental Hematology. 24, 9, 1 p.

Research output: Contribution to journalArticle

1995

Human Parainfluenza Virus Type 3 Phosphoprotein: Identification of Serine 333 as the Major Site for PKC ζ Phosphorylation

Huntley, C. C., De, B. P., Murray, N. R., Fields, A. P. & Banerjee, A. K., Aug 20 1995, In : Virology. 211, 2, p. 561-567 7 p., 71438.

Research output: Contribution to journalArticle

25 Scopus citations

Hypophosphorylation of topoisomerase II in etoposide (VP-16)-resistant human leukemia K562 cells associated with reduced levels of β(II) protein kinase C

Ritke, M. K., Murray, N. R., Allan, W. P., Fields, A. P. & Yalowich, J. C., Jan 1 1995, In : Molecular pharmacology. 48, 5, p. 798-805 8 p.

Research output: Contribution to journalArticle

31 Scopus citations
Open Access
38 Scopus citations
1994

Presence of a β(II) protein kinase C-selective nuclear membrane activation factor in human leukemia cells

Murray, N. R., Burns, D. J. & Fields, A. P., Jan 1 1994, In : Journal of Biological Chemistry. 269, 33, p. 21385-21390 6 p.

Research output: Contribution to journalArticle

48 Scopus citations
1993
188 Scopus citations
1992
18 Scopus citations
1989

Conversion of human erythrocyte acetylcholinesterase from an amphiphilic to a hydrophilic form by phosphatidylinositol‐specific phospholipase C and serum phospholipase D

TOUTANT, JP. P., ROBERTS, W. L., MURRAY, N. R. & ROSENBERRY, T. L., Apr 1989, In : European Journal of Biochemistry. 180, 3, p. 503-508 6 p.

Research output: Contribution to journalArticle

55 Scopus citations