Research Output per year
Research Output 1989 2019
- 1 - 50 out of 53 results
- Publication Year, Title (descending)
2019
Oncogenic protein kinase Cι signaling mechanisms in lung cancer: Implications for improved therapeutic strategies
Yin, N., Liu, Y., Murray, N. R. & Fields, A. P., Jan 1 2019, (Accepted/In press) In : Advances in Biological Regulation. 100656.Research output: Contribution to journal › Article
Protein Kinase C
Lung Neoplasms
Squamous Cell Carcinoma
Therapeutics
Maintenance
3
Citations
(Scopus)
Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma
Yin, N., Liu, Y., Khoor, A., Wang, X., Thompson, E. A., Leitges, M., Justilien, V., Weems, C., Murray, N. R. & Fields, A. P., Aug 12 2019, In : Cancer cell. 36, 2, p. 156-167 12 p.Research output: Contribution to journal › Article
Catenins
Protein Kinase C
Neoplasms
Stem Cells
Wnt Signaling Pathway
2018
Protein kinase Cι: A versatile oncogene in the lung
Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Oncology. e1190886.Research output: Contribution to journal › Article
Oncogenes
Protein Kinase C
Lung
Neoplastic Stem Cells
Phenotype
2017
38
Citations
(Scopus)
Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma
Justilien, V., Ali, S. A., Jamieson, L., Yin, N., Cox, A. D., Der, C. J., Murray, N. R. & Fields, A. P., Feb 13 2017, In : Cancer Cell. 31, 2, p. 256-269 14 p.Research output: Contribution to journal › Article
Epithelial Cells
Ribosomal DNA
Guanine Nucleotide Exchange Factors
Carcinogenesis
Protein Kinase C
2
Citations
(Scopus)
Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC
Justilien, V., Lewis, K. C., Murray, N. R. & Fields, A. P., Jun 30 2017, (Accepted/In press) In : Small GTPases. p. 1-7 7 p.Research output: Contribution to journal › Article
Non-Small Cell Lung Carcinoma
Epithelial Cells
Squamous Cell Carcinoma
rho GTP-Binding Proteins
Ribosomes
2016
Oncogenic PKCι decides tumor-initiating cell fate
Fields, A. P., Ali, S. A. & Murray, N. R., Sep 16 2016, In : Cell Cycle. 15, 18, p. 2383-2384 2 p.Research output: Contribution to journal › Comment/debate
Asymmetric Cell Division
Neoplastic Stem Cells
Lung Neoplasms
16
Citations
(Scopus)
PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis
Wang, Y., Justilien, V., Brennan, K. I., Jamieson, L., Murray, N. R. & Fields, A. P., Jun 20 2016, (Accepted/In press) In : Oncogene.Research output: Contribution to journal › Article
Ovarian Neoplasms
Protein Kinase C
Carcinogenesis
Carcinoma
Growth
38
Citations
(Scopus)
Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma
Ali, S. A., Justilien, V., Jamieson, L., Murray, N. R. & Fields, A. P., Mar 14 2016, In : Cancer Cell. 29, 3, p. 367-378 12 p.Research output: Contribution to journal › Article
Protein Kinase C
Phenotype
Asymmetric Cell Division
Adenocarcinoma of lung
Neoplastic Stem Cells
5
Citations
(Scopus)
SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse
Murray, N. R., Justilien, V. & Fields, A. P., Oct 10 2016, In : Cancer Cell. 30, 4, p. 505-507 3 p.Research output: Contribution to journal › Short survey
Squamous Cell Carcinoma
Lung
Neoplasms
Lung Neoplasms
3
Citations
(Scopus)
Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC
Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jun 30 2016, (Accepted/In press) In : Small GTPases. p. 1-7 7 p.Research output: Contribution to journal › Article
Protein Kinases
Protein Kinase C
Drug Combinations
Tumors
Lung Neoplasms
22
Citations
(Scopus)
The chromosome 3q26 OncCassette: A multigenic driver of human cancer
Fields, A. P., Justilien, V. & Murray, N. R., Jan 1 2016, In : Advances in Biological Regulation. 60, p. 47-63 17 p.Research output: Contribution to journal › Article
Chromosomes
Genes
Neoplasms
Squamous Cell Carcinoma
Lung
2015
19
Citations
(Scopus)
A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion
Butler, A. M., Scotti Buzhardt, M. L., Erdogan, E., Li, S., Inman, K. S., Fields, A. P. & Murray, N. R., 2015, In : Oncotarget. 6, 17, p. 15297-15310 14 p.Research output: Contribution to journal › Article
Pancreatic Neoplasms
Growth
Gold Sodium Thiomalate
PKC-3 protein
protein kinase C lambda
33
Citations
(Scopus)
Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia
Liou, G. Y., Döppler, H., Braun, U. B., Panayiotou, R., Scotti Buzhardt, M., Radisky, D. C., Crawford, H. C., Fields, A. P., Murray, N. R., Wang, Q. J., Leitges, M. & Storz, P., Feb 20 2015, In : Nature Communications. 6, 6200.Research output: Contribution to journal › Article
Acinar Cells
Metaplasia
Epidermal Growth Factor Receptor
progressions
Protein Kinases
2014
56
Citations
(Scopus)
Complex role for the immune system in initiation and progression of pancreatic cancer
Inman, K. S., Francis, A. A. & Murray, N. R., Aug 28 2014, In : World Journal of Gastroenterology. 20, 32, p. 11160-11181 22 p.Research output: Contribution to journal › Article
Pancreatic Neoplasms
Immune System
Adenocarcinoma
Neoplasms
Immunosuppressive Agents
17
Citations
(Scopus)
Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis
Hill, K. S., Erdogan, E., Khoor, A., Walsh, M. P., Leitges, M., Murray, N. R. & Fields, A. P., Apr 17 2014, In : Oncogene. 33, 16, p. 2134-2144 11 p.Research output: Contribution to journal › Article
Protein Kinase C-alpha
p38 Mitogen-Activated Protein Kinases
Protein Kinase C
Alveolar Epithelial Cells
Lung
159
Citations
(Scopus)
The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma
Justilien, V., Walsh, M. P., Ali, S. A., Thompson, E. A., Murray, N. R. & Fields, A. P., Feb 10 2014, In : Cancer Cell. 25, 2, p. 139-151 13 p.Research output: Contribution to journal › Article
Acyltransferases
Oncogenes
Protein Kinase C
Squamous Cell Carcinoma
Lung
2013
24
Citations
(Scopus)
Protein Kinase C Zeta Regulates Human Pancreatic Cancer Cell Transformed Growth and Invasion through a STAT3-Dependent Mechanism
Butler, A. M., Scotti Buzhardt, M. L., Li, S., Smith, K. E., Fields, A. P. & Murray, N. R., Aug 28 2013, In : PLoS One. 8, 8, e72061.Research output: Contribution to journal › Article
pancreatic neoplasms
STAT3 Transcription Factor
cell invasion
protein kinase C
Cell growth
2012
262
Citations
(Scopus)
EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis
Ardito, C. M., Grüner, B. M., Takeuchi, K. K., Lubeseder-Martellato, C., Teichmann, N., Mazur, P. K., DelGiorno, K. E., Carpenter, E. S., Halbrook, C. J., Hall, J. C., Pal, D., Briel, T., Herner, A., Trajkovic-Arsic, M., Sipos, B., Liou, G. Y., Storz, P., Murray, N. R., Threadgill, D. W., Sibilia, M. & 6 others, , Sep 11 2012, In : Cancer Cell. 22, 3, p. 304-317 14 p.Research output: Contribution to journal › Article
Epidermal Growth Factor Receptor
Carcinogenesis
Adenocarcinoma
Mitogen-Activated Protein Kinase Kinases
Oncogenes
53
Citations
(Scopus)
Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential
Justilien, V., Regala, R. P., Tseng, I. C., Walsh, M. P., Batra, J., Radisky, E. S., Murray, N. R. & Fields, A. P., Apr 24 2012, In : PLoS One. 7, 4, e35040.Research output: Contribution to journal › Article
stromelysin 2
Matrix Metalloproteinase 10
Neoplastic Stem Cells
lung neoplasms
Stem cells
11
Citations
(Scopus)
Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia
Scotti, M. L., Smith, K. E., Butler, A. M., Calcagno, S. R., Crawford, H. C., Leitges, M., Fields, A. P. & Murray, N. R., Feb 16 2012, In : PLoS One. 7, 2, e30509.Research output: Contribution to journal › Article
metaplasia
Metaplasia
protein kinase C
transforming growth factor alpha
Transforming Growth Factor alpha
2011
22
Citations
(Scopus)
Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation
Regala, R. P., Justilien, V., Walsh, M. P., Weems, C., Khoor, A., Murray, N. R. & Fields, A. P., Oct 17 2011, In : PLoS One. 6, 10, e26439.Research output: Contribution to journal › Article
stromelysin 2
Matrix Metalloproteinase 10
Alveolar Epithelial Cells
lung neoplasms
Stem cells
12
Citations
(Scopus)
Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis
Calcagno, S. R., Li, S., Shahid, M. W., Wallace, M. B., Leitges, M., Fields, A. P. & Murray, N. R., Aug 2011, In : Inflammatory Bowel Diseases. 17, 8, p. 1685-1697 13 p.Research output: Contribution to journal › Article
Dextran Sulfate
Colitis
Intestinal Mucosa
Wound Healing
Homeostasis
75
Citations
(Scopus)
Protein kinase Cι expression and oncogenic signaling mechanisms in cancer
Murray, N. R., Kalari, K. R. & Fields, A. P., Apr 2011, In : Journal of Cellular Physiology. 226, 4, p. 879-887 9 p.Research output: Contribution to journal › Article
Gold Sodium Thiomalate
Protein Kinase C
Tumors
Stem cells
Oncogenes
2010
61
Citations
(Scopus)
Protein kinase Cι is required for pancreatic cancer cell transformed growth and tumorigenesis
Scotti, M. L., Bamlet, W. R., Smyrk, T. C., Fields, A. P. & Murray, N. R., Mar 1 2010, In : Cancer Research. 70, 5, p. 2064-2074 11 p.Research output: Contribution to journal › Article
Pancreatic Neoplasms
Protein Kinase C
Carcinogenesis
Growth
Neoplasm Metastasis
Use of a body condition score technique to assess health status in a rat model of polycystic kidney disease
Gades, N. M. & Murray, N. R., May 2010, In : Journal of the American Association for Laboratory Animal Science. 49, 3, p. 269 1 p.Research output: Contribution to journal › Article
animal disease models
Animal Disease Models
Polycystic Kidney Diseases
Body Composition
health status
2009
32
Citations
(Scopus)
Protein kinase C βII and PKCι/λ: Collaborating partners in colon cancer promotion and progression
Murray, N. R., Weems, J., Braun, U., Leitges, M. & Fields, A. P., Jan 15 2009, In : Cancer Research. 69, 2, p. 656-662 7 p.Research output: Contribution to journal › Article
Colonic Neoplasms
Protein Kinases
Protein Kinase C
Colon
Carcinogenesis
19
Citations
(Scopus)
Protein kinase cβ is an effective target for chemoprevention of colon cancer
Fields, A. P., Calcagno, S. R., Krishna, M., Rak, S., Leitges, M. & Murray, N. R., Feb 15 2009, In : Cancer Research. 69, 4, p. 1643-1650 8 p.Research output: Contribution to journal › Article
Chemoprevention
Colonic Neoplasms
Protein Kinases
Catenins
Colon
2008
43
Citations
(Scopus)
Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon
Calcagno, S. R., Li, S., Colon, M., Kreinest, P. A., Thompson, E. A., Fields, A. P. & Murray, N. R., Jun 1 2008, In : International Journal of Cancer. 122, 11, p. 2462-2470 9 p.Research output: Contribution to journal › Article
Colon
Carcinogenesis
Aberrant Crypt Foci
Azoxymethane
Colonic Neoplasms
29
Citations
(Scopus)
Protein kinase C isozymes as therapeutic targets for treatment of human cancers
Fields, A. P. & Murray, N. R., 2008, In : Advances in Enzyme Regulation. 48, 1, p. 166-178 13 p.Research output: Contribution to journal › Article
Protein Kinase C
Isoenzymes
Oncogenes
Neoplasms
Genes
12
Citations
(Scopus)
The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice
Su, W., Necela, B. M., Fujiwara, K., Kurakata, S., Murray, N. R., Fields, A. P. & Thompson, E. A., Sep 1 2008, In : International Journal of Cancer. 123, 5, p. 991-997 7 p.Research output: Contribution to journal › Article
Azoxymethane
PPAR gamma
Colon
Neoplasms
Peroxisome Proliferator-Activated Receptors
2007
44
Citations
(Scopus)
Differential expression, distribution, and function of PPAR-γ in the proximal and distal colon
Su, W., Bush, C. R., Necela, B. M., Calcagno, S. R., Murray, N. R., Fields, A. P. & Thompson, E. A., Aug 20 2007, In : Physiological Genomics. 30, 3, p. 342-353 12 p.Research output: Contribution to journal › Article
Peroxisome Proliferator-Activated Receptors
Colon
Epithelial Cells
Genes
Signal Transduction
2006
120
Citations
(Scopus)
A novel small-molecule inhibitor of protein kinase Cι blocks transformed growth of non-small-cell lung cancer cells
Stailings-Mann, M., Jamieson, L., Regala, R. P., Weems, C., Murray, N. R. & Fields, A. P., Feb 1 2006, In : Cancer Research. 66, 3, p. 1767-1774 8 p.Research output: Contribution to journal › Article
Non-Small Cell Lung Carcinoma
Protein Kinase C
Aurothioglucose
Growth
Gold Sodium Thiomalate
2004
44
Citations
(Scopus)
Protein kinase C beta;II regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo
Liu, Y., Su, W., Thompson, E. A., Leitges, M., Murray, N. R. & Fields, A. P., Oct 29 2004, In : Journal of Biological Chemistry. 279, 44, p. 45556-45563 8 p.Research output: Contribution to journal › Article
Protein Kinase C beta
Protein Kinase C
Rats
Epithelium
Epithelial Cells
113
Citations
(Scopus)
Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo
Murray, N. R., Jamieson, L., Yu, W., Zhang, J., Gökmen-Polar, Y., Sier, D., Anastasiadis, P. Z., Gatalica, Z., Thompson, E. A. & Fields, A. P., Mar 15 2004, In : Journal of Cell Biology. 164, 6, p. 797-802 6 p.Research output: Contribution to journal › Article
Protein Kinase C
Colon
Carcinogenesis
Carcinogens
Phosphotransferases
2003
7
Citations
(Scopus)
Characterization of the role of protein kinase C isozymes in colon carcinogenesis using transgenic mouse models.
Fields, A. P., Murray, N. R. & Gustafson, W. C., 2003, In : Methods in molecular biology (Clifton, N.J.). 233, p. 539-553 15 p.Research output: Contribution to journal › Article
Azoxymethane
Animal Disease Models
Carcinogens
Colonic Neoplasms
Protein Kinase C
66
Citations
(Scopus)
Role of cyclooxygenase 2 in protein kinase C βII-mediated colon carcinogenesis
Yu, W., Murray, N. R., Weems, C., Chen, L., Guo, H., Ethridge, R., Ceci, J. D., Evers, B. M., Thompson, E. A. & Fields, A. P., Mar 28 2003, In : Journal of Biological Chemistry. 278, 13, p. 11167-11174 8 p.Research output: Contribution to journal › Article
Cyclooxygenase 2
Protein Kinase C
Colon
Carcinogenesis
Celecoxib
2002
60
Citations
(Scopus)
Protein kinase C βII and TGFβRII in ω-3 fatty acid-mediated inhibition of colon carcinogenesis
Murray, N. R., Weems, C., Chen, L., Leon, J., Wangsheng, W., Davidson, L. A., Jamieson, L., Chapkin, R. S., Thompson, E. A. & Fields, A. P., Jun 10 2002, In : Journal of Cell Biology. 157, 6, p. 915-920 6 p.Research output: Contribution to journal › Article
Growth Factor Receptors
Transforming Growth Factors
Protein Kinase C
Colon
Carcinogenesis
2001
167
Citations
(Scopus)
Elevated protein kinase C βII is an early promotive event in colon carcinogenesis
Gökmen-Polar, Y., Murray, N. R., Velasco, M. A., Gatalica, Z. & Fields, A. P., Feb 15 2001, In : Cancer Research. 61, 4, p. 1375-1381 7 p.Research output: Contribution to journal › Article
Protein Kinase C
Colon
Carcinogenesis
Aberrant Crypt Foci
Azoxymethane
1999
65
Citations
(Scopus)
Interleukin-1-induced nuclear factor-κB-IκB α autoregulatory feedback loop in hepatocytes. A role for protein kinase Cα in post-transcriptional regulation of IκBα resynthesis
Han, Y., Meng, T., Murray, N. R., Fields, A. P. & Brasier, A. R., Jan 8 1999, In : Journal of Biological Chemistry. 274, 2, p. 939-947 9 p.Research output: Contribution to journal › Article
Interleukin-1
Protein Kinase C
Hepatocytes
Feedback
Tumor Necrosis Factor-alpha
145
Citations
(Scopus)
Overexpression of protein kinase C β(II) induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis
Murray, N. R., Davidson, L. A., Chapkin, R. S., Gustafson, W. C., Schattenberg, D. G. & Fields, A. P., May 17 1999, In : Journal of Cell Biology. 145, 4, p. 699-711 13 p.Research output: Contribution to journal › Article
Protein Kinase C
Colon
Carcinogenesis
Catenins
Adenomatous Polyposis Coli
65
Citations
(Scopus)
Protein kinase Cα regulates human monocyte O2̇ production and low density lipoprotein lipid oxidation
Li, Q., Subbulakshmi, V., Fields, A. P., Murray, N. R. & Cathcart, M. K., Feb 5 1999, In : Journal of Biological Chemistry. 274, 6, p. 3764-3771 8 p.Research output: Contribution to journal › Article
LDL Lipoproteins
Protein Kinase C
Monocytes
Lipids
Oxidation
1998
59
Citations
(Scopus)
Phosphatidylglycerol is a physiologic activator of nuclear protein kinase C
Murray, N. R. & Fields, A. P., May 8 1998, In : Journal of Biological Chemistry. 273, 19, p. 11514-11520 7 p.Research output: Contribution to journal › Article
Phosphatidylglycerols
Nuclear Proteins
Protein Kinase C
Nuclear Envelope
Chemical activation
1997
104
Citations
(Scopus)
A role for nuclear phosphatidylinositol-specific phospholipase C in the G2/M phase transition
Sun, B., Murray, N. R. & Fields, A. P., Oct 17 1997, In : Journal of Biological Chemistry. 272, 42, p. 26313-26317 5 p.Research output: Contribution to journal › Article
Phosphoinositide Phospholipase C
G2 Phase
Diglycerides
Phase Transition
Cell Division
151
Citations
(Scopus)
Atypical protein kinase C ι protects human leukemia cells against drug- induced apoptosis
Murray, N. R. & Fields, A. P., Oct 31 1997, In : Journal of Biological Chemistry. 272, 44, p. 27521-27524 4 p.Research output: Contribution to journal › Article
Protein Kinase C
Leukemia
Apoptosis
K562 Cells
Pharmaceutical Preparations
1996
Identification of molecular determinants for protein kinase c isotype-specific functions in human leukemia cell proliferation and differentiation
Murray, N. R., Walker, S. D., Burns, D. J. & Fields, A. P., 1996, In : FASEB Journal. 10, 6Research output: Contribution to journal › Article
chimerism
Cell proliferation
leukemia
active sites
cell differentiation
The PKC agonist bryostatjn 1 stimulates developmental hematopoies1s in embryonic stem (ES) cells
Kalma, G. D., Smith, O. M., Murray, N. R., Carr, B., Field, A. & May, W. S., 1996, In : Experimental Hematology. 24, 9, p. 1028 1 p.Research output: Contribution to journal › Article
Embryonic Stem Cells
Protein Isoforms
Hematopoiesis
Proteins
Embryoid Bodies
1995
25
Citations
(Scopus)
Human Parainfluenza Virus Type 3 Phosphoprotein: Identification of Serine 333 as the Major Site for PKC ζ Phosphorylation
Huntley, C. C., De, B. P., Murray, N. R., Fields, A. P. & Banerjee, A. K., Aug 20 1995, In : Virology. 211, 2, p. 561-567 7 p.Research output: Contribution to journal › Article
Human parainfluenza virus 3
Phosphoproteins
Serine
Protein Kinase C
Phosphorylation
31
Citations
(Scopus)
Hypophosphorylation of topoisomerase II in etoposide (VP-16)-resistant human leukemia K562 cells associated with reduced levels of βII protein kinase C
Ritke, M. K., Murray, N. R., Allan, W. P., Fields, A. P. & Yalowich, J. C., Nov 1995, In : Molecular Pharmacology. 48, 5, p. 798-805 8 p.Research output: Contribution to journal › Article
Type II DNA Topoisomerase
K562 Cells
Etoposide
Protein Kinase C
Leukemia
37
Citations
(Scopus)
Protein kinase C chimeras: Catalytic domains of α and βII protein kinase C contain determinants for isotype-specific function
Walker, S. D., Murray, N. R., Burns, D. J. & Fields, A. P., Sep 26 1995, In : Proceedings of the National Academy of Sciences of the United States of America. 92, 20, p. 9156-9160 5 p.Research output: Contribution to journal › Article
Protein Kinase C
Catalytic Domain
Lamin Type B
Leukemia, Erythroblastic, Acute
Nuclear Envelope
1994
46
Citations
(Scopus)
Presence of a βII Protein Kinase C-selective Nuclear Membrane Activation Factor in Human Leukemia Cells
Murray, N. R., Burns, D. J. & Fields, A. P., Aug 19 1994, In : Journal of Biological Chemistry. 269, 33, p. 21385-21390 6 p.Research output: Contribution to journal › Article
Nuclear Envelope
Protein Kinase C
Leukemia
Lamin Type B
Chemical activation