Research Output per year
Research Output
2020
Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in Lung Squamous Cell Carcinoma
Liu, Y., Yin, N., Wang, X., Khoor, A., Sambandam, V., Ghosh, A. B., Fields, Z. A., Murray, N. R., Justilien, V. & Fields, A. P., Jan 21 2020, In : Cell reports. 30, 3, p. 771-782.e6Research output: Contribution to journal › Article
Open Access
Oncogenic protein kinase Cι signaling mechanisms in lung cancer: Implications for improved therapeutic strategies
Yin, N., Liu, Y., Murray, N. R. & Fields, A. P., Jan 2020, In : Advances in Biological Regulation. 75, 100656.Research output: Contribution to journal › Article
1
Scopus
citations
2019
Erratum: Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma (Cancer Cell (2019) 36(2) (156–167.e7), (S1535610819303290), (10.1016/j.ccell.2019.07.002))
Yin, N., Liu, Y., Khoor, A., Wang, X., Thompson, E. A., Leitges, M., Justilien, V., Weems, C., Murray, N. R. & Fields, A. P., Dec 9 2019, In : Cancer cell. 36, 6, p. 692-693 2 p.Research output: Contribution to journal › Comment/debate
Open Access
Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC
Justilien, V., Lewis, K. C., Murray, N. R. & Fields, A. P., Sep 3 2019, In : Small GTPases. 10, 5, p. 388-394 7 p.Research output: Contribution to journal › Article
3
Scopus
citations
Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma
Yin, N., Liu, Y., Khoor, A., Wang, X., Thompson, E. A., Leitges, M., Justilien, V., Weems, C., Murray, N. R. & Fields, A. P., Aug 12 2019, In : Cancer cell. 36, 2, p. 156-167.e7Research output: Contribution to journal › Article
3
Scopus
citations
2018
Protein kinase Cι: A versatile oncogene in the lung
Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Oncology. e1190886.Research output: Contribution to journal › Article
2017
Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma
Justilien, V., Ali, S. A., Jamieson, L., Yin, N., Cox, A. D., Der, C. J., Murray, N. R. & Fields, A. P., Feb 13 2017, In : Cancer Cell. 31, 2, p. 256-269 14 p.Research output: Contribution to journal › Article
45
Scopus
citations
2016
Oncogenic PKCι decides tumor-initiating cell fate
Fields, A. P., Ali, S. A. & Murray, N. R., Sep 16 2016, In : Cell Cycle. 15, 18, p. 2383-2384 2 p.Research output: Contribution to journal › Comment/debate
PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis
Wang, Y., Justilien, V., Brennan, K. I., Jamieson, L., Murray, N. R. & Fields, A. P., Jun 20 2016, (Accepted/In press) In : Oncogene.Research output: Contribution to journal › Article
20
Scopus
citations
Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma
Ali, S. A., Justilien, V., Jamieson, L., Murray, N. R. & Fields, A. P., Mar 14 2016, In : Cancer Cell. 29, 3, p. 367-378 12 p.Research output: Contribution to journal › Article
41
Scopus
citations
SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse
Murray, N. R., Justilien, V. & Fields, A. P., Oct 10 2016, In : Cancer Cell. 30, 4, p. 505-507 3 p.Research output: Contribution to journal › Short survey
6
Scopus
citations
Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC
Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jun 30 2016, (Accepted/In press) In : Small GTPases. p. 1-7 7 p.Research output: Contribution to journal › Article
3
Scopus
citations
The chromosome 3q26 OncCassette: A multigenic driver of human cancer
Fields, A. P., Justilien, V. & Murray, N. R., Jan 1 2016, In : Advances in Biological Regulation. 60, p. 47-63 17 p.Research output: Contribution to journal › Article
27
Scopus
citations
2015
A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion
Butler, A. M., Scotti Buzhardt, M. L., Erdogan, E., Li, S., Inman, K. S., Fields, A. P. & Murray, N. R., 2015, In : Oncotarget. 6, 17, p. 15297-15310 14 p.Research output: Contribution to journal › Article
21
Scopus
citations
Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia
Liou, G. Y., Döppler, H., Braun, U. B., Panayiotou, R., Scotti Buzhardt, M., Radisky, D. C., Crawford, H. C., Fields, A. P., Murray, N. R., Wang, Q. J., Leitges, M. & Storz, P., Feb 20 2015, In : Nature communications. 6, 6200.Research output: Contribution to journal › Article
35
Scopus
citations
2014
Complex role for the immune system in initiation and progression of pancreatic cancer
Inman, K. S., Francis, A. A. & Murray, N. R., Aug 28 2014, In : World journal of gastroenterology. 20, 32, p. 11160-11181 22 p.Research output: Contribution to journal › Review article
61
Scopus
citations
Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis
Hill, K. S., Erdogan, E., Khoor, A., Walsh, M. P., Leitges, M., Murray, N. R. & Fields, A. P., Apr 17 2014, In : Oncogene. 33, 16, p. 2134-2144 11 p.Research output: Contribution to journal › Article
19
Scopus
citations
The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma
Justilien, V., Walsh, M. P., Ali, S. A., Thompson, E. A., Murray, N. R. & Fields, A. P., Feb 10 2014, In : Cancer cell. 25, 2, p. 139-151 13 p.Research output: Contribution to journal › Article
171
Scopus
citations
2013
Protein Kinase C Zeta Regulates Human Pancreatic Cancer Cell Transformed Growth and Invasion through a STAT3-Dependent Mechanism
Butler, A. M., Scotti Buzhardt, M. L., Li, S., Smith, K. E., Fields, A. P. & Murray, N. R., Aug 28 2013, In : PloS one. 8, 8, e72061.Research output: Contribution to journal › Article
24
Scopus
citations
2012
EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis
Ardito, C. M., Grüner, B. M., Takeuchi, K. K., Lubeseder-Martellato, C., Teichmann, N., Mazur, P. K., DelGiorno, K. E., Carpenter, E. S., Halbrook, C. J., Hall, J. C., Pal, D., Briel, T., Herner, A., Trajkovic-Arsic, M., Sipos, B., Liou, G. Y., Storz, P., Murray, N. R., Threadgill, D. W., Sibilia, M. & 6 others, , Sep 11 2012, In : Cancer cell. 22, 3, p. 304-317 14 p.Research output: Contribution to journal › Article
283
Scopus
citations
Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential
Justilien, V., Regala, R. P., Tseng, I. C., Walsh, M. P., Batra, J., Radisky, E. S., Murray, N. R. & Fields, A. P., Apr 24 2012, In : PloS one. 7, 4, e35040.Research output: Contribution to journal › Article
59
Scopus
citations
Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia
Scotti, M. L., Smith, K. E., Butler, A. M., Calcagno, S. R., Crawford, H. C., Leitges, M., Fields, A. P. & Murray, N. R., Feb 16 2012, In : PloS one. 7, 2, e30509.Research output: Contribution to journal › Article
11
Scopus
citations
2011
Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation
Regala, R. P., Justilien, V., Walsh, M. P., Weems, C., Khoor, A., Murray, N. R. & Fields, A. P., Oct 17 2011, In : PloS one. 6, 10, e26439.Research output: Contribution to journal › Article
24
Scopus
citations
Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis
Calcagno, S. R., Li, S., Shahid, M. W., Wallace, M. B., Leitges, M., Fields, A. P. & Murray, N. R., Aug 1 2011, In : Inflammatory bowel diseases. 17, 8, p. 1685-1697 13 p.Research output: Contribution to journal › Article
13
Scopus
citations
Protein kinase Cι expression and oncogenic signaling mechanisms in cancer
Murray, N. R., Kalari, K. R. & Fields, A. P., Apr 1 2011, In : Journal of Cellular Physiology. 226, 4, p. 879-887 9 p.Research output: Contribution to journal › Review article
77
Scopus
citations
2010
Protein kinase Cι is required for pancreatic cancer cell transformed growth and tumorigenesis
Scotti, M. L., Bamlet, W. R., Smyrk, T. C., Fields, A. P. & Murray, N. R., Mar 1 2010, In : Cancer research. 70, 5, p. 2064-2074 11 p.Research output: Contribution to journal › Article
62
Scopus
citations
Use of a body condition score technique to assess health status in a rat model of polycystic kidney disease
Gades, N. M. & Murray, N., May 1 2010, In : Journal of the American Association for Laboratory Animal Science. 49, 3, 1 p.Research output: Contribution to journal › Letter
2009
Protein kinase C βII and PKCι/λ: Collaborating partners in colon cancer promotion and progression
Murray, N. R., Weems, J., Braun, U., Leitges, M. & Fields, A. P., Jan 15 2009, In : Cancer research. 69, 2, p. 656-662 7 p.Research output: Contribution to journal › Article
32
Scopus
citations
Protein kinase cβ is an effective target for chemoprevention of colon cancer
Fields, A. P., Calcagno, S. R., Krishna, M., Rak, S., Leitges, M. & Murray, N. R., Feb 15 2009, In : Cancer research. 69, 4, p. 1643-1650 8 p.Research output: Contribution to journal › Article
19
Scopus
citations
2008
Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon
Calcagno, S. R., Li, S., Colon, M., Kreinest, P. A., Thompson, E. A., Fields, A. P. & Murray, N. R., Jun 1 2008, In : International Journal of Cancer. 122, 11, p. 2462-2470 9 p.Research output: Contribution to journal › Article
43
Scopus
citations
Protein kinase C isozymes as therapeutic targets for treatment of human cancers
Fields, A. P. & Murray, N. R., Sep 15 2008, In : Advances in Enzyme Regulation. 48, 1, p. 166-178 13 p.Research output: Contribution to journal › Article
29
Scopus
citations
The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice
Su, W., Necela, B. M., Fujiwara, K., Kurakata, S., Murray, N. R., Fields, A. P. & Thompson, E. A., Sep 1 2008, In : International Journal of Cancer. 123, 5, p. 991-997 7 p.Research output: Contribution to journal › Article
12
Scopus
citations
2007
Differential expression, distribution, and function of PPAR-γ in the proximal and distal colon
Su, W., Bush, C. R., Necela, B. M., Calcagno, S. R., Murray, N. R., Fields, A. P. & Thompson, E. A., Aug 20 2007, In : Physiological Genomics. 30, 3, p. 342-353 12 p.Research output: Contribution to journal › Article
45
Scopus
citations
2006
A novel small-molecule inhibitor of protein kinase Cι blocks transformed growth of non-small-cell lung cancer cells
Stailings-Mann, M., Jamieson, L., Regala, R. P., Weems, C., Murray, N. R. & Fields, A. P., Feb 1 2006, In : Cancer research. 66, 3, p. 1767-1774 8 p.Research output: Contribution to journal › Article
123
Scopus
citations
2004
Protein kinase C beta;II regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo
Liu, Y., Su, W., Thompson, E. A., Leitges, M., Murray, N. R. & Fields, A. P., Oct 29 2004, In : Journal of Biological Chemistry. 279, 44, p. 45556-45563 8 p.Research output: Contribution to journal › Article
44
Scopus
citations
Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo
Murray, N. R., Jamieson, L., Yu, W., Zhang, J., Gökmen-Polar, Y., Sier, D., Anastasiadis, P., Gatalica, Z., Thompson, E. A. & Fields, A. P., Mar 15 2004, In : Journal of Cell Biology. 164, 6, p. 797-802 6 p.Research output: Contribution to journal › Article
113
Scopus
citations
2003
Characterization of the role of protein kinase C isozymes in colon carcinogenesis using transgenic mouse models.
Fields, A. P., Murray, N. R. & Gustafson, W. C., 2003, In : Methods in molecular biology (Clifton, N.J.). 233, p. 539-553 15 p.Research output: Contribution to journal › Article
7
Scopus
citations
Role of cyclooxygenase 2 in protein kinase C βII-mediated colon carcinogenesis
Yu, W., Murray, N. R., Weems, C., Chen, L., Guo, H., Ethridge, R., Ceci, J. D., Evers, B. M., Thompson, E. A. & Fields, A. P., Mar 28 2003, In : Journal of Biological Chemistry. 278, 13, p. 11167-11174 8 p.Research output: Contribution to journal › Article
66
Scopus
citations
2002
Protein kinase C βII and TGFβRII in ω-3 fatty acid-mediated inhibition of colon carcinogenesis
Murray, N. R., Weems, C., Chen, L., Leon, J., Wangsheng, W., Davidson, L. A., Jamieson, L., Chapkin, R. S., Aubrey Thompson, E. & Fields, A. P., Jun 10 2002, In : Journal of Cell Biology. 157, 6, p. 915-920 6 p.Research output: Contribution to journal › Article
61
Scopus
citations
2001
Elevated protein kinase C βII is an early promotive event in colon carcinogenesis
Gökmen-Polar, Y., Murray, N. R., Velasco, M. A., Gatalica, Z. & Fields, A. P., Feb 15 2001, In : Cancer research. 61, 4, p. 1375-1381 7 p.Research output: Contribution to journal › Article
168
Scopus
citations
1999
Interleukin-1-induced nuclear factor-κB-IκB α autoregulatory feedback loop in hepatocytes. A role for protein kinase Cα in post-transcriptional regulation of IκBα resynthesis
Han, Y., Meng, T., Murray, N. R., Fields, A. P. & Brasier, A. R., Jan 8 1999, In : Journal of Biological Chemistry. 274, 2, p. 939-947 9 p.Research output: Contribution to journal › Article
66
Scopus
citations
Overexpression of protein kinase C β(II) induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis
Murray, N. R., Davidson, L. A., Chapkin, R. S., Gustafson, W. C., Schattenberg, D. G. & Fields, A. P., May 17 1999, In : Journal of Cell Biology. 145, 4, p. 699-711 13 p.Research output: Contribution to journal › Article
145
Scopus
citations
Protein kinase Cα regulates human monocyte O2̇ production and low density lipoprotein lipid oxidation
Li, Q., Subbulakshmi, V., Fields, A. P., Murray, N. R. & Cathcart, M. K., Feb 5 1999, In : Journal of Biological Chemistry. 274, 6, p. 3764-3771 8 p.Research output: Contribution to journal › Article
66
Scopus
citations
1998
Phosphatidylglycerol is a physiologic activator of nuclear protein kinase C
Murray, N. R. & Fields, A. P., May 8 1998, In : Journal of Biological Chemistry. 273, 19, p. 11514-11520 7 p.Research output: Contribution to journal › Article
60
Scopus
citations
1997
A role for nuclear phosphatidylinositol-specific phospholipase C in the G2/M phase transition
Sun, B., Murray, N. R. & Fields, A. P., Oct 17 1997, In : Journal of Biological Chemistry. 272, 42, p. 26313-26317 5 p.Research output: Contribution to journal › Article
104
Scopus
citations
Atypical protein kinase C ι protects human leukemia cells against drug- induced apoptosis
Murray, N. R. & Fields, A. P., Oct 31 1997, In : Journal of Biological Chemistry. 272, 44, p. 27521-27524 4 p.Research output: Contribution to journal › Article
151
Scopus
citations
1996
Identification of molecular determinants for protein kinase c isotype-specific functions in human leukemia cell proliferation and differentiation
Murray, N. R., Walker, S. D., Burns, D. J. & Fields, A. P., Dec 1 1996, In : FASEB Journal. 10, 6, p. A1513Research output: Contribution to journal › Article
The PKC agonist bryostatjn 1 stimulates developmental hematopoies1s in embryonic stem (ES) cells
Kalma, G. D., Smith, O. M., Murray, N., Carr, B., Field, A. & May, W. S., Dec 1 1996, In : Experimental Hematology. 24, 9, 1 p.Research output: Contribution to journal › Article
1995
Human Parainfluenza Virus Type 3 Phosphoprotein: Identification of Serine 333 as the Major Site for PKC ζ Phosphorylation
Huntley, C. C., De, B. P., Murray, N. R., Fields, A. P. & Banerjee, A. K., Aug 20 1995, In : Virology. 211, 2, p. 561-567 7 p., 71438.Research output: Contribution to journal › Article
25
Scopus
citations
Hypophosphorylation of topoisomerase II in etoposide (VP-16)-resistant human leukemia K562 cells associated with reduced levels of β(II) protein kinase C
Ritke, M. K., Murray, N. R., Allan, W. P., Fields, A. P. & Yalowich, J. C., Jan 1 1995, In : Molecular pharmacology. 48, 5, p. 798-805 8 p.Research output: Contribution to journal › Article
31
Scopus
citations