Research output per year
Research output per year
- 1 - 50 out of 59 results
Search results
-
2022
Prkci Regulates Autophagy and Pancreatic Tumorigenesis in Mice
Inman, K. S., Liu, Y., Scotti Buzhardt, M. L., Leitges, M., Krishna, M., Crawford, H. H., Fields, A. P. & Murray, N. R., Feb 1 2022, In: Cancers. 14, 3, 796.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Protein kinase Cι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities
Kenchappa, R. S., Liu, Y., Argenziano, M. G., Banu, M. A., Mladek, A. C., West, R., Luu, A., Quiñones-Hinojosa, A., Hambardzumyan, D., Justilien, V., Leitges, M., Sarkaria, J. N., Sims, P. A., Canoll, P., Murray, N. R., Fields, A. P. & Rosenfeld, S. S., Nov 23 2021, In: Cell reports. 37, 8, 110054.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Chromosome 3q26 Gain Is an Early Event Driving Coordinated Overexpression of the PRKCI, SOX2, and ECT2 Oncogenes in Lung Squamous Cell Carcinoma
Liu, Y., Yin, N., Wang, X., Khoor, A., Sambandam, V., Ghosh, A. B., Fields, Z. A., Murray, N. R., Justilien, V. & Fields, A. P., Jan 21 2020, In: Cell reports. 30, 3, p. 771-782.e6Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Oncogenic protein kinase Cι signaling mechanisms in lung cancer: Implications for improved therapeutic strategies
Yin, N., Liu, Y., Murray, N. R. & Fields, A. P., Jan 2020, In: Advances in Biological Regulation. 75, 100656.Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Protein kinase Cℓ promotes UBF1-ECT2 binding on ribosomal DNA to drive rRNA synthesis and transformed growth of nonsmall-cell lung cancer cells
Justilien, V., Lewis, K. C., Meneses, K. M., Jamieson, L., Murray, N. R. & Fields, A. P., Jun 12 2020, In: Journal of Biological Chemistry. 295, 24, p. 8214-8226 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Recurrent copy number gains drive PKCι expression and PKCι-dependent oncogenic signaling in human cancers
Liu, Y., Justilien, V., Fields, A. P. & Murray, N. R., Dec 2020, In: Advances in Biological Regulation. 78, 100754.Research output: Contribution to journal › Article › peer-review
-
2019
Erratum: Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma (Cancer Cell (2019) 36(2) (156–167.e7), (S1535610819303290), (10.1016/j.ccell.2019.07.002))
Yin, N., Liu, Y., Khoor, A., Wang, X., Thompson, E. A., Leitges, M., Justilien, V., Weems, C., Murray, N. R. & Fields, A. P., Dec 9 2019, In: Cancer cell. 36, 6, p. 692-693 2 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access1 Scopus citations -
Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC
Justilien, V., Lewis, K. C., Murray, N. R. & Fields, A. P., Sep 3 2019, In: Small GTPases. 10, 5, p. 388-394 7 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma
Yin, N., Liu, Y., Khoor, A., Wang, X., Thompson, E. A., Leitges, M., Justilien, V., Weems, C., Murray, N. R. & Fields, A. P., Aug 12 2019, In: Cancer cell. 36, 2, p. 156-167.e7Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
2018
Protein kinase Cι: A versatile oncogene in the lung
Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Sep 3 2018, In: Molecular and Cellular Oncology. 5, 5, e1190886.Research output: Contribution to journal › Comment/debate › peer-review
1 Scopus citations -
2017
Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma
Justilien, V., Ali, S. A., Jamieson, L., Yin, N., Cox, A. D., Der, C. J., Murray, N. R. & Fields, A. P., Feb 13 2017, In: Cancer cell. 31, 2, p. 256-269 14 p.Research output: Contribution to journal › Article › peer-review
60 Scopus citations -
PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis
Wang, Y., Justilien, V., Brennan, K. I., Jamieson, L., Murray, N. R. & Fields, A. P., Jan 26 2017, In: Oncogene. 36, 4, p. 534-545 12 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC
Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jan 2 2017, In: Small GTPases. 8, 1, p. 58-64 7 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
2016
Oncogenic PKCι decides tumor-initiating cell fate
Fields, A. P., Ali, S. A. & Murray, N. R., Sep 16 2016, In: Cell Cycle. 15, 18, p. 2383-2384 2 p.Research output: Contribution to journal › Comment/debate › peer-review
-
Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma
Ali, S. A., Justilien, V., Jamieson, L., Murray, N. R. & Fields, A. P., Mar 14 2016, In: Cancer cell. 29, 3, p. 367-378 12 p.Research output: Contribution to journal › Article › peer-review
54 Scopus citations -
SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse
Murray, N. R., Justilien, V. & Fields, A. P., Oct 10 2016, In: Cancer cell. 30, 4, p. 505-507 3 p.Research output: Contribution to journal › Short survey › peer-review
8 Scopus citations -
The chromosome 3q26 OncCassette: A multigenic driver of human cancer
Fields, A. P., Justilien, V. & Murray, N. R., Jan 1 2016, In: Advances in Biological Regulation. 60, p. 47-63 17 p.Research output: Contribution to journal › Article › peer-review
44 Scopus citations -
2015
A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion
Butler, A. M., Scotti Buzhardt, M. L., Erdogan, E., Li, S., Inman, K. S., Fields, A. P. & Murray, N. R., 2015, In: Oncotarget. 6, 17, p. 15297-15310 14 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations -
Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia
Liou, G. Y., Döppler, H., Braun, U. B., Panayiotou, R., Scotti Buzhardt, M., Radisky, D. C., Crawford, H. C., Fields, A. P., Murray, N. R., Wang, Q. J., Leitges, M. & Storz, P., Feb 20 2015, In: Nature communications. 6, 6200.Research output: Contribution to journal › Article › peer-review
44 Scopus citations -
2014
Complex role for the immune system in initiation and progression of pancreatic cancer
Inman, K. S., Francis, A. A. & Murray, N. R., Aug 28 2014, In: World journal of gastroenterology. 20, 32, p. 11160-11181 22 p.Research output: Contribution to journal › Review article › peer-review
75 Scopus citations -
Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis
Hill, K. S., Erdogan, E., Khoor, A., Walsh, M. P., Leitges, M., Murray, N. R. & Fields, A. P., Apr 17 2014, In: Oncogene. 33, 16, p. 2134-2144 11 p.Research output: Contribution to journal › Article › peer-review
30 Scopus citations -
The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma
Justilien, V., Walsh, M. P., Ali, S. A., Thompson, E. A., Murray, N. R. & Fields, A. P., Feb 10 2014, In: Cancer cell. 25, 2, p. 139-151 13 p.Research output: Contribution to journal › Article › peer-review
197 Scopus citations -
2013
Protein Kinase C Zeta Regulates Human Pancreatic Cancer Cell Transformed Growth and Invasion through a STAT3-Dependent Mechanism
Butler, A. M., Scotti Buzhardt, M. L., Li, S., Smith, K. E., Fields, A. P. & Murray, N. R., Aug 28 2013, In: PloS one. 8, 8, e72061.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
2012
EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis
Ardito, C. M., Grüner, B. M., Takeuchi, K. K., Lubeseder-Martellato, C., Teichmann, N., Mazur, P. K., DelGiorno, K. E., Carpenter, E. S., Halbrook, C. J., Hall, J. C., Pal, D., Briel, T., Herner, A., Trajkovic-Arsic, M., Sipos, B., Liou, G. Y., Storz, P., Murray, N. R., Threadgill, D. W., Sibilia, M., & 6 others, Sep 11 2012, In: Cancer cell. 22, 3, p. 304-317 14 p.Research output: Contribution to journal › Article › peer-review
328 Scopus citations -
Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential
Justilien, V., Regala, R. P., Tseng, I. C., Walsh, M. P., Batra, J., Radisky, E. S., Murray, N. R. & Fields, A. P., Apr 24 2012, In: PloS one. 7, 4, e35040.Research output: Contribution to journal › Article › peer-review
67 Scopus citations -
Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia
Scotti, M. L., Smith, K. E., Butler, A. M., Calcagno, S. R., Crawford, H. C., Leitges, M., Fields, A. P. & Murray, N. R., Feb 16 2012, In: PloS one. 7, 2, e30509.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
2011
Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation
Regala, R. P., Justilien, V., Walsh, M. P., Weems, C., Khoor, A., Murray, N. R. & Fields, A. P., Oct 17 2011, In: PloS one. 6, 10, e26439.Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis
Calcagno, S. R., Li, S., Shahid, M. W., Wallace, M. B., Leitges, M., Fields, A. P. & Murray, N. R., Aug 2011, In: Inflammatory bowel diseases. 17, 8, p. 1685-1697 13 p.Research output: Contribution to journal › Article › peer-review
16 Scopus citations -
Protein kinase Cι expression and oncogenic signaling mechanisms in cancer
Murray, N. R., Kalari, K. R. & Fields, A. P., Apr 2011, In: Journal of Cellular Physiology. 226, 4, p. 879-887 9 p.Research output: Contribution to journal › Review article › peer-review
84 Scopus citations -
2010
Protein kinase Cι is required for pancreatic cancer cell transformed growth and tumorigenesis
Scotti, M. L., Bamlet, W. R., Smyrk, T. C., Fields, A. P. & Murray, N. R., Mar 1 2010, In: Cancer research. 70, 5, p. 2064-2074 11 p.Research output: Contribution to journal › Article › peer-review
68 Scopus citations -
Use of a body condition score technique to assess health status in a rat model of polycystic kidney disease
Gades, N. M. & Murray, N., May 1 2010, In: Journal of the American Association for Laboratory Animal Science. 49, 3, 1 p.Research output: Contribution to journal › Letter › peer-review
-
2009
Protein kinase C βII and PKCι/λ: Collaborating partners in colon cancer promotion and progression
Murray, N. R., Weems, J., Braun, U., Leitges, M. & Fields, A. P., Jan 15 2009, In: Cancer research. 69, 2, p. 656-662 7 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
Protein kinase cβ is an effective target for chemoprevention of colon cancer
Fields, A. P., Calcagno, S. R., Krishna, M., Rak, S., Leitges, M. & Murray, N. R., Feb 15 2009, In: Cancer research. 69, 4, p. 1643-1650 8 p.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
2008
Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon
Calcagno, S. R., Li, S., Colon, M., Kreinest, P. A., Thompson, E. A., Fields, A. P. & Murray, N. R., Jun 1 2008, In: International Journal of Cancer. 122, 11, p. 2462-2470 9 p.Research output: Contribution to journal › Article › peer-review
48 Scopus citations -
Protein kinase C isozymes as therapeutic targets for treatment of human cancers
Fields, A. P. & Murray, N. R., 2008, In: Advances in Enzyme Regulation. 48, 1, p. 166-178 13 p.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice
Su, W., Necela, B. M., Fujiwara, K., Kurakata, S., Murray, N. R., Fields, A. P. & Thompson, E. A., Sep 1 2008, In: International Journal of Cancer. 123, 5, p. 991-997 7 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
2007
Differential expression, distribution, and function of PPAR-γ in the proximal and distal colon
Su, W., Bush, C. R., Necela, B. M., Calcagno, S. R., Murray, N. R., Fields, A. P. & Thompson, E. A., Aug 20 2007, In: Physiological Genomics. 30, 3, p. 342-353 12 p.Research output: Contribution to journal › Article › peer-review
47 Scopus citations -
2006
A novel small-molecule inhibitor of protein kinase Cι blocks transformed growth of non-small-cell lung cancer cells
Stailings-Mann, M., Jamieson, L., Regala, R. P., Weems, C., Murray, N. R. & Fields, A. P., Feb 1 2006, In: Cancer research. 66, 3, p. 1767-1774 8 p.Research output: Contribution to journal › Article › peer-review
128 Scopus citations -
2004
Protein kinase C beta;II regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo
Liu, Y., Su, W., Thompson, E. A., Leitges, M., Murray, N. R. & Fields, A. P., Oct 29 2004, In: Journal of Biological Chemistry. 279, 44, p. 45556-45563 8 p.Research output: Contribution to journal › Article › peer-review
45 Scopus citations -
Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo
Murray, N. R., Jamieson, L., Yu, W., Zhang, J., Gökmen-Polar, Y., Sier, D., Anastasiadis, P., Gatalica, Z., Thompson, E. A. & Fields, A. P., Mar 15 2004, In: Journal of Cell Biology. 164, 6, p. 797-802 6 p.Research output: Contribution to journal › Article › peer-review
120 Scopus citations -
2003
Characterization of the role of protein kinase C isozymes in colon carcinogenesis using transgenic mouse models.
Fields, A. P., Murray, N. R. & Gustafson, W. C., 2003, In: Methods in molecular biology (Clifton, N.J.). 233, p. 539-553 15 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
Role of cyclooxygenase 2 in protein kinase C βII-mediated colon carcinogenesis
Yu, W., Murray, N. R., Weems, C., Chen, L., Guo, H., Ethridge, R., Ceci, J. D., Evers, B. M., Thompson, E. A. & Fields, A. P., Mar 28 2003, In: Journal of Biological Chemistry. 278, 13, p. 11167-11174 8 p.Research output: Contribution to journal › Article › peer-review
68 Scopus citations -
2002
Protein kinase C βII and TGFβRII in ω-3 fatty acid-mediated inhibition of colon carcinogenesis
Murray, N. R., Weems, C., Chen, L., Leon, J., Wangsheng, W., Davidson, L. A., Jamieson, L., Chapkin, R. S., Aubrey Thompson, E. & Fields, A. P., Jun 10 2002, In: Journal of Cell Biology. 157, 6, p. 915-920 6 p.Research output: Contribution to journal › Article › peer-review
63 Scopus citations -
2001
Elevated protein kinase C βII is an early promotive event in colon carcinogenesis
Gökmen-Polar, Y., Murray, N. R., Velasco, M. A., Gatalica, Z. & Fields, A. P., Feb 15 2001, In: Cancer research. 61, 4, p. 1375-1381 7 p.Research output: Contribution to journal › Article › peer-review
173 Scopus citations -
1999
Interleukin-1-induced nuclear factor-κB-IκB α autoregulatory feedback loop in hepatocytes. A role for protein kinase Cα in post-transcriptional regulation of IκBα resynthesis
Han, Y., Meng, T., Murray, N. R., Fields, A. P. & Brasier, A. R., Jan 8 1999, In: Journal of Biological Chemistry. 274, 2, p. 939-947 9 p.Research output: Contribution to journal › Article › peer-review
69 Scopus citations -
Overexpression of protein kinase C β(II) induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis
Murray, N. R., Davidson, L. A., Chapkin, R. S., Gustafson, W. C., Schattenberg, D. G. & Fields, A. P., May 17 1999, In: Journal of Cell Biology. 145, 4, p. 699-711 13 p.Research output: Contribution to journal › Article › peer-review
149 Scopus citations -
Protein kinase Cα regulates human monocyte O2̇ production and low density lipoprotein lipid oxidation
Li, Q., Subbulakshmi, V., Fields, A. P., Murray, N. R. & Cathcart, M. K., Feb 5 1999, In: Journal of Biological Chemistry. 274, 6, p. 3764-3771 8 p.Research output: Contribution to journal › Article › peer-review
66 Scopus citations -
1998
Phosphatidylglycerol is a physiologic activator of nuclear protein kinase C
Murray, N. R. & Fields, A. P., May 8 1998, In: Journal of Biological Chemistry. 273, 19, p. 11514-11520 7 p.Research output: Contribution to journal › Article › peer-review
64 Scopus citations -
1997
A role for nuclear phosphatidylinositol-specific phospholipase C in the G2/M phase transition
Sun, B., Murray, N. R. & Fields, A. P., Oct 17 1997, In: Journal of Biological Chemistry. 272, 42, p. 26313-26317 5 p.Research output: Contribution to journal › Article › peer-review
105 Scopus citations -
Atypical protein kinase C ι protects human leukemia cells against drug- induced apoptosis
Murray, N. R. & Fields, A. P., Oct 31 1997, In: Journal of Biological Chemistry. 272, 44, p. 27521-27524 4 p.Research output: Contribution to journal › Article › peer-review
154 Scopus citations