Nicole R Murray, PhD

  • 2675 Citations
  • 29 Scopus h-Index
1989 …2019
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Research Output 1989 2019

  • 2675 Citations
  • 29 Scopus h-Index
  • 51 Article
  • 1 Comment/debate
  • 1 Short survey
2019

Oncogenic protein kinase Cι signaling mechanisms in lung cancer: Implications for improved therapeutic strategies

Yin, N., Liu, Y., Murray, N. R. & Fields, A. P., Jan 1 2019, (Accepted/In press) In : Advances in Biological Regulation. 100656.

Research output: Contribution to journalArticle

Protein Kinase C
Lung Neoplasms
Squamous Cell Carcinoma
Therapeutics
Maintenance
3 Citations (Scopus)

Protein Kinase Cι and Wnt/β-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma

Yin, N., Liu, Y., Khoor, A., Wang, X., Thompson, E. A., Leitges, M., Justilien, V., Weems, C., Murray, N. R. & Fields, A. P., Aug 12 2019, In : Cancer cell. 36, 2, p. 156-167 12 p.

Research output: Contribution to journalArticle

Catenins
Protein Kinase C
Neoplasms
Stem Cells
Wnt Signaling Pathway
2018

Protein kinase Cι: A versatile oncogene in the lung

Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jan 1 2018, (Accepted/In press) In : Molecular and Cellular Oncology. e1190886.

Research output: Contribution to journalArticle

Oncogenes
Protein Kinase C
Lung
Neoplastic Stem Cells
Phenotype
2017
38 Citations (Scopus)

Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma

Justilien, V., Ali, S. A., Jamieson, L., Yin, N., Cox, A. D., Der, C. J., Murray, N. R. & Fields, A. P., Feb 13 2017, In : Cancer Cell. 31, 2, p. 256-269 14 p.

Research output: Contribution to journalArticle

Epithelial Cells
Ribosomal DNA
Guanine Nucleotide Exchange Factors
Carcinogenesis
Protein Kinase C
2 Citations (Scopus)

Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC

Justilien, V., Lewis, K. C., Murray, N. R. & Fields, A. P., Jun 30 2017, (Accepted/In press) In : Small GTPases. p. 1-7 7 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Epithelial Cells
Squamous Cell Carcinoma
rho GTP-Binding Proteins
Ribosomes
2016

Oncogenic PKCι decides tumor-initiating cell fate

Fields, A. P., Ali, S. A. & Murray, N. R., Sep 16 2016, In : Cell Cycle. 15, 18, p. 2383-2384 2 p.

Research output: Contribution to journalComment/debate

Asymmetric Cell Division
Neoplastic Stem Cells
Lung Neoplasms
16 Citations (Scopus)

PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis

Wang, Y., Justilien, V., Brennan, K. I., Jamieson, L., Murray, N. R. & Fields, A. P., Jun 20 2016, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Protein Kinase C
Carcinogenesis
Carcinoma
Growth
38 Citations (Scopus)

Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma

Ali, S. A., Justilien, V., Jamieson, L., Murray, N. R. & Fields, A. P., Mar 14 2016, In : Cancer Cell. 29, 3, p. 367-378 12 p.

Research output: Contribution to journalArticle

Protein Kinase C
Phenotype
Asymmetric Cell Division
Adenocarcinoma of lung
Neoplastic Stem Cells
5 Citations (Scopus)

SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse

Murray, N. R., Justilien, V. & Fields, A. P., Oct 10 2016, In : Cancer Cell. 30, 4, p. 505-507 3 p.

Research output: Contribution to journalShort survey

Squamous Cell Carcinoma
Lung
Neoplasms
Lung Neoplasms
3 Citations (Scopus)

Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC

Fields, A. P., Ali, S. A., Justilien, V. & Murray, N. R., Jun 30 2016, (Accepted/In press) In : Small GTPases. p. 1-7 7 p.

Research output: Contribution to journalArticle

Protein Kinases
Protein Kinase C
Drug Combinations
Tumors
Lung Neoplasms
22 Citations (Scopus)

The chromosome 3q26 OncCassette: A multigenic driver of human cancer

Fields, A. P., Justilien, V. & Murray, N. R., Jan 1 2016, In : Advances in Biological Regulation. 60, p. 47-63 17 p.

Research output: Contribution to journalArticle

Chromosomes
Genes
Neoplasms
Squamous Cell Carcinoma
Lung
2015
19 Citations (Scopus)

A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion

Butler, A. M., Scotti Buzhardt, M. L., Erdogan, E., Li, S., Inman, K. S., Fields, A. P. & Murray, N. R., 2015, In : Oncotarget. 6, 17, p. 15297-15310 14 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Growth
Gold Sodium Thiomalate
PKC-3 protein
protein kinase C lambda
33 Citations (Scopus)

Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia

Liou, G. Y., Döppler, H., Braun, U. B., Panayiotou, R., Scotti Buzhardt, M., Radisky, D. C., Crawford, H. C., Fields, A. P., Murray, N. R., Wang, Q. J., Leitges, M. & Storz, P., Feb 20 2015, In : Nature Communications. 6, 6200.

Research output: Contribution to journalArticle

Acinar Cells
Metaplasia
Epidermal Growth Factor Receptor
progressions
Protein Kinases
2014
56 Citations (Scopus)

Complex role for the immune system in initiation and progression of pancreatic cancer

Inman, K. S., Francis, A. A. & Murray, N. R., Aug 28 2014, In : World Journal of Gastroenterology. 20, 32, p. 11160-11181 22 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Immune System
Adenocarcinoma
Neoplasms
Immunosuppressive Agents
17 Citations (Scopus)

Protein kinase Cα suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFβ signaling axis

Hill, K. S., Erdogan, E., Khoor, A., Walsh, M. P., Leitges, M., Murray, N. R. & Fields, A. P., Apr 17 2014, In : Oncogene. 33, 16, p. 2134-2144 11 p.

Research output: Contribution to journalArticle

Protein Kinase C-alpha
p38 Mitogen-Activated Protein Kinases
Protein Kinase C
Alveolar Epithelial Cells
Lung
159 Citations (Scopus)

The PRKCI and SOX2 Oncogenes Are Coamplified and Cooperate to Activate Hedgehog Signaling in Lung Squamous Cell Carcinoma

Justilien, V., Walsh, M. P., Ali, S. A., Thompson, E. A., Murray, N. R. & Fields, A. P., Feb 10 2014, In : Cancer Cell. 25, 2, p. 139-151 13 p.

Research output: Contribution to journalArticle

Acyltransferases
Oncogenes
Protein Kinase C
Squamous Cell Carcinoma
Lung
2013
24 Citations (Scopus)

Protein Kinase C Zeta Regulates Human Pancreatic Cancer Cell Transformed Growth and Invasion through a STAT3-Dependent Mechanism

Butler, A. M., Scotti Buzhardt, M. L., Li, S., Smith, K. E., Fields, A. P. & Murray, N. R., Aug 28 2013, In : PLoS One. 8, 8, e72061.

Research output: Contribution to journalArticle

pancreatic neoplasms
STAT3 Transcription Factor
cell invasion
protein kinase C
Cell growth
2012
262 Citations (Scopus)

EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis

Ardito, C. M., Grüner, B. M., Takeuchi, K. K., Lubeseder-Martellato, C., Teichmann, N., Mazur, P. K., DelGiorno, K. E., Carpenter, E. S., Halbrook, C. J., Hall, J. C., Pal, D., Briel, T., Herner, A., Trajkovic-Arsic, M., Sipos, B., Liou, G. Y., Storz, P., Murray, N. R., Threadgill, D. W., Sibilia, M. & 6 others, Washington, M. K., Wilson, C. L., Schmid, R. M., Raines, E. W., Crawford, H. C. & Siveke, J. T., Sep 11 2012, In : Cancer Cell. 22, 3, p. 304-317 14 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Carcinogenesis
Adenocarcinoma
Mitogen-Activated Protein Kinase Kinases
Oncogenes
53 Citations (Scopus)

Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential

Justilien, V., Regala, R. P., Tseng, I. C., Walsh, M. P., Batra, J., Radisky, E. S., Murray, N. R. & Fields, A. P., Apr 24 2012, In : PLoS One. 7, 4, e35040.

Research output: Contribution to journalArticle

stromelysin 2
Matrix Metalloproteinase 10
Neoplastic Stem Cells
lung neoplasms
Stem cells
11 Citations (Scopus)

Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia

Scotti, M. L., Smith, K. E., Butler, A. M., Calcagno, S. R., Crawford, H. C., Leitges, M., Fields, A. P. & Murray, N. R., Feb 16 2012, In : PLoS One. 7, 2, e30509.

Research output: Contribution to journalArticle

metaplasia
Metaplasia
protein kinase C
transforming growth factor alpha
Transforming Growth Factor alpha
2011
22 Citations (Scopus)

Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation

Regala, R. P., Justilien, V., Walsh, M. P., Weems, C., Khoor, A., Murray, N. R. & Fields, A. P., Oct 17 2011, In : PLoS One. 6, 10, e26439.

Research output: Contribution to journalArticle

stromelysin 2
Matrix Metalloproteinase 10
Alveolar Epithelial Cells
lung neoplasms
Stem cells
12 Citations (Scopus)

Protein kinase C iota in the intestinal epithelium protects against dextran sodium sulfate-induced colitis

Calcagno, S. R., Li, S., Shahid, M. W., Wallace, M. B., Leitges, M., Fields, A. P. & Murray, N. R., Aug 2011, In : Inflammatory Bowel Diseases. 17, 8, p. 1685-1697 13 p.

Research output: Contribution to journalArticle

Dextran Sulfate
Colitis
Intestinal Mucosa
Wound Healing
Homeostasis
75 Citations (Scopus)

Protein kinase Cι expression and oncogenic signaling mechanisms in cancer

Murray, N. R., Kalari, K. R. & Fields, A. P., Apr 2011, In : Journal of Cellular Physiology. 226, 4, p. 879-887 9 p.

Research output: Contribution to journalArticle

Gold Sodium Thiomalate
Protein Kinase C
Tumors
Stem cells
Oncogenes
2010
61 Citations (Scopus)

Protein kinase Cι is required for pancreatic cancer cell transformed growth and tumorigenesis

Scotti, M. L., Bamlet, W. R., Smyrk, T. C., Fields, A. P. & Murray, N. R., Mar 1 2010, In : Cancer Research. 70, 5, p. 2064-2074 11 p.

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Protein Kinase C
Carcinogenesis
Growth
Neoplasm Metastasis
animal disease models
Animal Disease Models
Polycystic Kidney Diseases
Body Composition
health status
2009
32 Citations (Scopus)

Protein kinase C βII and PKCι/λ: Collaborating partners in colon cancer promotion and progression

Murray, N. R., Weems, J., Braun, U., Leitges, M. & Fields, A. P., Jan 15 2009, In : Cancer Research. 69, 2, p. 656-662 7 p.

Research output: Contribution to journalArticle

Colonic Neoplasms
Protein Kinases
Protein Kinase C
Colon
Carcinogenesis
19 Citations (Scopus)

Protein kinase cβ is an effective target for chemoprevention of colon cancer

Fields, A. P., Calcagno, S. R., Krishna, M., Rak, S., Leitges, M. & Murray, N. R., Feb 15 2009, In : Cancer Research. 69, 4, p. 1643-1650 8 p.

Research output: Contribution to journalArticle

Chemoprevention
Colonic Neoplasms
Protein Kinases
Catenins
Colon
2008
43 Citations (Scopus)

Oncogenic K-ras promotes early carcinogenesis in the mouse proximal colon

Calcagno, S. R., Li, S., Colon, M., Kreinest, P. A., Thompson, E. A., Fields, A. P. & Murray, N. R., Jun 1 2008, In : International Journal of Cancer. 122, 11, p. 2462-2470 9 p.

Research output: Contribution to journalArticle

Colon
Carcinogenesis
Aberrant Crypt Foci
Azoxymethane
Colonic Neoplasms
29 Citations (Scopus)

Protein kinase C isozymes as therapeutic targets for treatment of human cancers

Fields, A. P. & Murray, N. R., 2008, In : Advances in Enzyme Regulation. 48, 1, p. 166-178 13 p.

Research output: Contribution to journalArticle

Protein Kinase C
Isoenzymes
Oncogenes
Neoplasms
Genes
12 Citations (Scopus)
Azoxymethane
PPAR gamma
Colon
Neoplasms
Peroxisome Proliferator-Activated Receptors
2007
44 Citations (Scopus)

Differential expression, distribution, and function of PPAR-γ in the proximal and distal colon

Su, W., Bush, C. R., Necela, B. M., Calcagno, S. R., Murray, N. R., Fields, A. P. & Thompson, E. A., Aug 20 2007, In : Physiological Genomics. 30, 3, p. 342-353 12 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Colon
Epithelial Cells
Genes
Signal Transduction
2006
120 Citations (Scopus)

A novel small-molecule inhibitor of protein kinase Cι blocks transformed growth of non-small-cell lung cancer cells

Stailings-Mann, M., Jamieson, L., Regala, R. P., Weems, C., Murray, N. R. & Fields, A. P., Feb 1 2006, In : Cancer Research. 66, 3, p. 1767-1774 8 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Protein Kinase C
Aurothioglucose
Growth
Gold Sodium Thiomalate
2004
44 Citations (Scopus)

Protein kinase C beta;II regulates its own expression in rat intestinal epithelial cells and the colonic epithelium in vivo

Liu, Y., Su, W., Thompson, E. A., Leitges, M., Murray, N. R. & Fields, A. P., Oct 29 2004, In : Journal of Biological Chemistry. 279, 44, p. 45556-45563 8 p.

Research output: Contribution to journalArticle

Protein Kinase C beta
Protein Kinase C
Rats
Epithelium
Epithelial Cells
113 Citations (Scopus)

Protein kinase Cι is required for Ras transformation and colon carcinogenesis in vivo

Murray, N. R., Jamieson, L., Yu, W., Zhang, J., Gökmen-Polar, Y., Sier, D., Anastasiadis, P. Z., Gatalica, Z., Thompson, E. A. & Fields, A. P., Mar 15 2004, In : Journal of Cell Biology. 164, 6, p. 797-802 6 p.

Research output: Contribution to journalArticle

Protein Kinase C
Colon
Carcinogenesis
Carcinogens
Phosphotransferases
2003
7 Citations (Scopus)
Azoxymethane
Animal Disease Models
Carcinogens
Colonic Neoplasms
Protein Kinase C
66 Citations (Scopus)

Role of cyclooxygenase 2 in protein kinase C βII-mediated colon carcinogenesis

Yu, W., Murray, N. R., Weems, C., Chen, L., Guo, H., Ethridge, R., Ceci, J. D., Evers, B. M., Thompson, E. A. & Fields, A. P., Mar 28 2003, In : Journal of Biological Chemistry. 278, 13, p. 11167-11174 8 p.

Research output: Contribution to journalArticle

Cyclooxygenase 2
Protein Kinase C
Colon
Carcinogenesis
Celecoxib
2002
60 Citations (Scopus)

Protein kinase C βII and TGFβRII in ω-3 fatty acid-mediated inhibition of colon carcinogenesis

Murray, N. R., Weems, C., Chen, L., Leon, J., Wangsheng, W., Davidson, L. A., Jamieson, L., Chapkin, R. S., Thompson, E. A. & Fields, A. P., Jun 10 2002, In : Journal of Cell Biology. 157, 6, p. 915-920 6 p.

Research output: Contribution to journalArticle

Growth Factor Receptors
Transforming Growth Factors
Protein Kinase C
Colon
Carcinogenesis
2001
167 Citations (Scopus)

Elevated protein kinase C βII is an early promotive event in colon carcinogenesis

Gökmen-Polar, Y., Murray, N. R., Velasco, M. A., Gatalica, Z. & Fields, A. P., Feb 15 2001, In : Cancer Research. 61, 4, p. 1375-1381 7 p.

Research output: Contribution to journalArticle

Protein Kinase C
Colon
Carcinogenesis
Aberrant Crypt Foci
Azoxymethane
1999
65 Citations (Scopus)
Interleukin-1
Protein Kinase C
Hepatocytes
Feedback
Tumor Necrosis Factor-alpha
145 Citations (Scopus)

Overexpression of protein kinase C β(II) induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis

Murray, N. R., Davidson, L. A., Chapkin, R. S., Gustafson, W. C., Schattenberg, D. G. & Fields, A. P., May 17 1999, In : Journal of Cell Biology. 145, 4, p. 699-711 13 p.

Research output: Contribution to journalArticle

Protein Kinase C
Colon
Carcinogenesis
Catenins
Adenomatous Polyposis Coli
65 Citations (Scopus)

Protein kinase Cα regulates human monocyte O2̇ production and low density lipoprotein lipid oxidation

Li, Q., Subbulakshmi, V., Fields, A. P., Murray, N. R. & Cathcart, M. K., Feb 5 1999, In : Journal of Biological Chemistry. 274, 6, p. 3764-3771 8 p.

Research output: Contribution to journalArticle

LDL Lipoproteins
Protein Kinase C
Monocytes
Lipids
Oxidation
1998
59 Citations (Scopus)

Phosphatidylglycerol is a physiologic activator of nuclear protein kinase C

Murray, N. R. & Fields, A. P., May 8 1998, In : Journal of Biological Chemistry. 273, 19, p. 11514-11520 7 p.

Research output: Contribution to journalArticle

Phosphatidylglycerols
Nuclear Proteins
Protein Kinase C
Nuclear Envelope
Chemical activation
1997
104 Citations (Scopus)

A role for nuclear phosphatidylinositol-specific phospholipase C in the G2/M phase transition

Sun, B., Murray, N. R. & Fields, A. P., Oct 17 1997, In : Journal of Biological Chemistry. 272, 42, p. 26313-26317 5 p.

Research output: Contribution to journalArticle

Phosphoinositide Phospholipase C
G2 Phase
Diglycerides
Phase Transition
Cell Division
151 Citations (Scopus)

Atypical protein kinase C ι protects human leukemia cells against drug- induced apoptosis

Murray, N. R. & Fields, A. P., Oct 31 1997, In : Journal of Biological Chemistry. 272, 44, p. 27521-27524 4 p.

Research output: Contribution to journalArticle

Protein Kinase C
Leukemia
Apoptosis
K562 Cells
Pharmaceutical Preparations
1996
chimerism
Cell proliferation
leukemia
active sites
cell differentiation

The PKC agonist bryostatjn 1 stimulates developmental hematopoies1s in embryonic stem (ES) cells

Kalma, G. D., Smith, O. M., Murray, N. R., Carr, B., Field, A. & May, W. S., 1996, In : Experimental Hematology. 24, 9, p. 1028 1 p.

Research output: Contribution to journalArticle

Embryonic Stem Cells
Protein Isoforms
Hematopoiesis
Proteins
Embryoid Bodies
1995
25 Citations (Scopus)

Human Parainfluenza Virus Type 3 Phosphoprotein: Identification of Serine 333 as the Major Site for PKC ζ Phosphorylation

Huntley, C. C., De, B. P., Murray, N. R., Fields, A. P. & Banerjee, A. K., Aug 20 1995, In : Virology. 211, 2, p. 561-567 7 p.

Research output: Contribution to journalArticle

Human parainfluenza virus 3
Phosphoproteins
Serine
Protein Kinase C
Phosphorylation
31 Citations (Scopus)

Hypophosphorylation of topoisomerase II in etoposide (VP-16)-resistant human leukemia K562 cells associated with reduced levels of βII protein kinase C

Ritke, M. K., Murray, N. R., Allan, W. P., Fields, A. P. & Yalowich, J. C., Nov 1995, In : Molecular Pharmacology. 48, 5, p. 798-805 8 p.

Research output: Contribution to journalArticle

Type II DNA Topoisomerase
K562 Cells
Etoposide
Protein Kinase C
Leukemia
37 Citations (Scopus)
Protein Kinase C
Catalytic Domain
Lamin Type B
Leukemia, Erythroblastic, Acute
Nuclear Envelope
1994
46 Citations (Scopus)

Presence of a βII Protein Kinase C-selective Nuclear Membrane Activation Factor in Human Leukemia Cells

Murray, N. R., Burns, D. J. & Fields, A. P., Aug 19 1994, In : Journal of Biological Chemistry. 269, 33, p. 21385-21390 6 p.

Research output: Contribution to journalArticle

Nuclear Envelope
Protein Kinase C
Leukemia
Lamin Type B
Chemical activation