• 26904 Citations
  • 93 Scopus h-Index
1973 …2019
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Research Output 1973 2019

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Article
2017
1 Citation (Scopus)

Doublecortin domain containing protein 2 (DCDC2) genetic variants in primary sclerosing cholangitis

Cheung, A. C., Juran, B. D., Moore, R. M., La Russo, N. F. & Lazaridis, K. N., 2017, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Protein Domains
4 Citations (Scopus)

Emerging pharmacologic therapies for primary sclerosing cholangitis

Cheung, A. C., Lazaridis, K. N., La Russo, N. F. & Gores, G. J., Mar 2 2017, (Accepted/In press) In : Current Opinion in Gastroenterology.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Immunomodulation
Microbiota
Pharmaceutical Preparations
Liver Transplantation
9 Citations (Scopus)

Epigenetics in the Primary Biliary Cholangitis and Primary Sclerosing Cholangitis

Cheung, A. C., La Russo, N. F., Gores, G. J. & Lazaridis, K. N., May 1 2017, In : Seminars in Liver Disease. 37, 2, p. 159-174 16 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Cholangitis
Epigenomics
Genes
Genome-Wide Association Study
8 Citations (Scopus)

ETS proto-oncogene 1 transcriptionally up-regulates the cholangiocyte senescence-associated protein cyclin-dependent kinase inhibitor 2A

O'Hara, S. P., Splinter, P. L., Trussoni, C. E., Lorenzo Pisarello, M. J., Loarca, L., Splinter, N. S., Schutte, B. F. & La Russo, N. F., Mar 24 2017, In : Journal of Biological Chemistry. 292, 12, p. 4833-4846 14 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase Inhibitor p16
Sclerosing Cholangitis
Proto-Oncogenes
Up-Regulation
Luciferases
9 Citations (Scopus)

Pathobiology of biliary epithelia

Cheung, A. C., Lorenzo Pisarello, M. J. & La Russo, N. F., 2017, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular Basis of Disease.

Research output: Contribution to journalArticle

Biliary Tract
Cell Cycle Checkpoints
Bile Acids and Salts
Neurotransmitter Agents
Disease Progression
3 Citations (Scopus)

Role of the Intestinal Microbiome in Cholestatic Liver Disease

La Russo, N. F., Tabibian, J. H. & O'Hara, S. P., Mar 1 2017, In : Digestive Diseases. 35, 3, p. 166-168 3 p.

Research output: Contribution to journalArticle

Microbiota
Liver Diseases
Health
Epigenomics
Liver
9 Citations (Scopus)

TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling

Masyuk, T. V., Masyuk, A. I., Lorenzo Pisarello, M., Howard, B. N., Huang, B. Q., Lee, P. Y., Fung, X., Sergienko, E., Ardecky, R. J., Chung, T. D. Y., Pinkerton, A. B. & La Russo, N. F., 2017, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

GTP-Binding Proteins
Cyclic AMP
Rodentia
Liver
Oleanolic Acid
2018
6 Citations (Scopus)

Cholangiocyte autophagy contributes to hepatic cystogenesis in polycystic liver disease and represents a potential therapeutic target

Masyuk, A. I., Masyuk, T. V., Lorenzo Pisarello, M. J., Ding, J. F., Loarca, L., Huang, B. Q. & La Russo, N. F., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Autophagy
Liver
Hydroxychloroquine
Polycystic Kidney Diseases
Therapeutics

Cholangiocytes in health and disease: From basic science to novel treatments

Banales, J. M., Marzioni, M., La Russo, N. F. & Jansen, P., Jan 1 2018, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular Basis of Disease.

Research output: Contribution to journalArticle

Health
2 Citations (Scopus)

Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease

Lorenzo Pisarello, M., Masyuk, T. V., Gradilone, S. A., Masyuk, A. I., Ding, J. F., Lee, P. Y. & La Russo, N. F., Apr 1 2018, In : American Journal of Pathology. 188, 4, p. 981-994 14 p.

Research output: Contribution to journalArticle

Somatostatin Receptors
Histone Deacetylase Inhibitors
Polycystic Kidney Diseases
Histone Deacetylases
Animal Models
13 Citations (Scopus)

Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice

Guicciardi, M. E., Trussoni, C. E., Krishnan, A., Bronk, S. F., Lorenzo Pisarello, M. J., O'Hara, S. P., Splinter, P. L., Gao, Y., Vig, P., Revzin, A., La Russo, N. F. & Gores, G. J., Jan 1 2018, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Macrophages
Liver
Monocytes
Wounds and Injuries
2 Citations (Scopus)

Metabolomic profiling of portal blood and bile reveals metabolic signatures of primary sclerosing cholangitis

Tietz-Bogert, P. S., Kim, M., Cheung, A., Tabibian, J. H., Heimbach, J. K., Rosen, C. B., Nandakumar, M., Lazaridis, K. N., La Russo, N. F., Sung, J. & O’hara, S. P., Oct 16 2018, In : International Journal of Molecular Sciences. 19, 10, 3188.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Metabolomics
metabolites
Bile
serums
7 Citations (Scopus)

MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma

Mansini, A. P., Lorenzo Pisarello, M. J., Thelen, K. M., Cruz-Reyes, M., Peixoto, E., Jin, S., Howard, B. N., Trussoni, C. E., Gajdos, G. B., La Russo, N. F., Perugorria, M. J., Banales, J. M. & Gradilone, S. A., Aug 1 2018, In : Hepatology. 68, 2, p. 561-573 13 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Cholangiocarcinoma
MicroRNAs
Karyopherins
Cilia
15 Citations (Scopus)

MicroRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation

Erice, O., Munoz-Garrido, P., Vaquero, J., Perugorria, M. J., Fernandez-Barrena, M. G., Saez, E., Santos-Laso, A., Arbelaiz, A., Jimenez-Agüero, R., Fernandez-Irigoyen, J., Santamaria, E., Torrano, V., Carracedo, A., Ananthanarayanan, M., Marzioni, M., Prieto, J., Beuers, U., Oude Elferink, R. P., La Russo, N. F., Bujanda, L. & 2 others, Marin, J. J. G. & Banales, J. M., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Cholangitis
MicroRNAs
Dihydrolipoyllysine-Residue Acetyltransferase
Chloride-Bicarbonate Antiporters
Cytokines
11 Citations (Scopus)

Milder disease stage in patients with primary biliary cholangitis over a 44-year period: A changing natural history

on behalf of the GLOBAL PBC Study Group, May 1 2018, In : Hepatology. 67, 5, p. 1920-1930 11 p.

Research output: Contribution to journalArticle

Cholangitis
Natural History
Ursodeoxycholic Acid
Paris
Gastroenterology

Polycystic liver disease: The interplay of genes causative for hepatic and renal cystogenesis

Masyuk, T. V., Masyuk, A. I. & La Russo, N. F., Jun 1 2018, In : Hepatology. 67, 6, p. 2462-2464 3 p.

Research output: Contribution to journalArticle

Kidney
Liver
Genes
Polycystic liver disease
16 Citations (Scopus)

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., Frantz, M. C., Bell-Temin, H., Pope-Varsalona, H., Gurkar, A. U., Nasto, L. A., Robinson, R. A. S., Fuhrmann-Stroissnigg, H., Czerwinska, J., McGowan, S. J., Cantu-Medellin, N. & 22 others, Harris, J. B., Maniar, S., Ross, M. A., Trussoni, C. E., La Russo, N. F., Cifuentes-Pagano, E., Pagano, P. J., Tudek, B., Vo, N. V., Rigatti, L. H., Opresko, P. L., Stolz, D. B., Watkins, S. C., Burd, C. E., Croix, C. M. S., Siuzdak, G., Yates, N. A., Robbins, P. D., Wang, Y., Wipf, P., Kelley, E. E. & Niedernhofer, L. J., Jul 1 2018, In : Redox Biology. 17, p. 259-273 15 p.

Research output: Contribution to journalArticle

DNA Damage
Oxidation-Reduction
Genes
Aging of materials
Genome
22 Citations (Scopus)

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice

Moncsek, A., Al-Suraih, M. S., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Zuber, C., Patsenker, E., Valli, P. V., Fingas, C. D., Weber, A., Zhu, Y., Tchkonia, T., Kirkland, J. L., Gores, G. J., Müllhaupt, B., La Russo, N. F. & Mertens, J. C., Jan 1 2018, In : Hepatology. 67, 1, p. 247-259 13 p.

Research output: Contribution to journalArticle

MDR Genes
Gene Knockout Techniques
B-Cell Lymphoma
Knockout Mice
Fibrosis
2019
1 Citation (Scopus)

Efficacy and safety of curcumin in primary sclerosing cholangitis: an open label pilot study

Eaton, J. E., Nelson, K. M., Gossard, A. A., Carey, E. J., Tabibian, J. H., Lindor, K. D. & La Russo, N. F., Jan 1 2019, In : Scandinavian Journal of Gastroenterology.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Curcumin
Alkaline Phosphatase
Safety
Serum
4 Citations (Scopus)

Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning

Eaton, J. E., Vesterhus, M., McCauley, B. M., Atkinson, E. J., Schlicht, E. M., Juran, B. D., Gossard, A. A., La Russo, N. F., Gores, G. J., Karlsen, T. H. & Lazaridis, K. N., Jan 1 2019, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Validation Studies
Confidence Intervals
Bilirubin
Alkaline Phosphatase