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Nicholas F La Russo, MD

  • 26897 Citations
  • 93 Scopus h-Index
1973 …2019
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Research Output 1973 2019

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Article
19 Citations (Scopus)

Primary sclerosing cholangitis

Ueno, Y. & La Russo, N. F., 1994, In : Journal of Gastroenterology. 29, 4, p. 531-543 13 p.

Research output: Contribution to journal › Article

Sclerosing Cholangitis
Cholangiography
Ulcerative Colitis
Inflammatory Bowel Diseases
Differential Diagnosis
39 Citations (Scopus)

Primary sclerosing cholangitis: A progressive disease?

Porayko, M. K., La Russo, N. F. & Wiesner, R. H., 1991, In : Seminars in Liver Disease. 11, 1, p. 18-25 8 p.

Research output: Contribution to journal › Article

Sclerosing Cholangitis
Disease Progression
Liver Failure
Survival
Endoscopic Retrograde Cholangiopancreatography
222 Citations (Scopus)

Primary sclerosing cholangitis: Refinement and validation of survival models

Dickson, E. R., Murtaugh, P. A., Wiesner, R. H., Grambsch, P. M., Fleming, T. R., Ludwig, J., La Russo, N. F., Malinchoc, M., Chapman, R. W., Kaplan, M. M., Maddrey, W. C., Williams, R., Farrant, M. & Langworthy, A., 1992, In : Gastroenterology. 103, 6, p. 1893-1901 9 p.

Research output: Contribution to journal › Article

Sclerosing Cholangitis
Survival
Splenomegaly
Survival Analysis
Bilirubin
341 Citations (Scopus)

Primary sclerosing cholangitis

La Russo, N. F., Wiesner, R. H., Ludwig, J. & MacCarty, R. L., 1984, In : New England Journal of Medicine. 310, 14, p. 899-903 5 p.

Research output: Contribution to journal › Article

Bile Duct Neoplasms
Intestinal Diseases
Sclerosing Cholangitis
Cholangitis
Cholangiography

Primary sclerosing cholangitis

Brennan, F., O'Connor, F. A. & La Russo, N. F., 1984, In : New England Journal of Medicine. 311, 5, p. 331 1 p.

Research output: Contribution to journal › Article

Sclerosing Cholangitis
Cholangitis
Sclerosis
Medical Societies
Incidence
200 Citations (Scopus)

Primary sclerosing cholangitis: Summary of a workshop

La Russo, N. F., Shneider, B. L., Black, D., Gores, G. J., James, S. P., Doo, E. & Hoofnagle, J. H., Sep 2006, In : Hepatology. 44, 3, p. 746-764 19 p.

Research output: Contribution to journal › Article

Sclerosing Cholangitis
Education
Liver Transplantation
Cholangiocarcinoma
Survival
30 Citations (Scopus)

Primary sclerosing cholangitis

Dickson, E. R., La Russo, N. F. & Wiesner, R. H., 1984, In : Hepatology. 4, 1 SUPPL.

Research output: Contribution to journal › Article

Sclerosing Cholangitis
Cholangitis
National Institutes of Health (U.S.)
Sclerosis
487 Citations (Scopus)

Primary sclerosing cholangitis: Natural history, prognostic factors and survival analysis

Wiesner, R. H., Grambsch, P. M., Dickson, E. R., Ludwig, J., MacCarty, R. L., Hunter, E. B., Fleming, T. R., Fisher, L. D., Beaver, S. J. & La Russo, N. F., 1989, In : Hepatology. 10, 4, p. 430-436 7 p.

Research output: Contribution to journal › Article

Sclerosing Cholangitis
Survival Analysis
Natural History
Statistical Factor Analysis
Inflammatory Bowel Diseases
61 Citations (Scopus)

Primary sclerosing cholangitis: Value of cholangiography in determining the prognosis

Craig, D. A., MacCarty, R. L., Wiesner, R. H., Grambsch, P. M. & La Russo, N. F., 1991, In : American Journal of Roentgenology. 157, 5, p. 959-964 6 p.

Research output: Contribution to journal › Article

Sclerosing Cholangitis
Cholangiography
Pathologic Constriction
Survival
Dilatation
15 Citations (Scopus)

Primary Sclerosing Cholangitis: The Gut-Liver Axis

Tabibian, J. H., O'Hara, S. P. & La Russo, N. F., Jul 2012, In : Clinical Gastroenterology and Hepatology. 10, 7, p. 819 1 p.

Research output: Contribution to journal › Article

Sclerosing Cholangitis
Inflammatory Bowel Diseases
Liver
115 Citations (Scopus)

Primary sclerosing cholangitis and celiac disease. A novel association

Hay, J. E., Wiesner, R. H., Shorter, R. G., La Russo, N. F. & Baldus, W. P., 1988, In : Annals of Internal Medicine. 109, 9, p. 713-717 5 p.

Research output: Contribution to journal › Article

Sclerosing Cholangitis
Celiac Disease
Steatorrhea
Fats
Gluten-Free Diet
4 Citations (Scopus)

Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning

Eaton, J. E., Vesterhus, M., McCauley, B. M., Atkinson, E. J., Schlicht, E. M., Juran, B. D., Gossard, A. A., La Russo, N. F., Gores, G. J., Karlsen, T. H. & Lazaridis, K. N., Jan 1 2019, (Accepted/In press) In : Hepatology.

Research output: Contribution to journal › Article

Sclerosing Cholangitis
Validation Studies
Confidence Intervals
Bilirubin
Alkaline Phosphatase
82 Citations (Scopus)

Primary sclerosing cholangitis with normal serum alkaline phosphatase activity

Balasubramaniam, K., Wiesner, R. H. & La Russo, N. F., 1988, In : Gastroenterology. 95, 5, p. 1395-1398 4 p.

Research output: Contribution to journal › Article

Sclerosing Cholangitis
Alkaline Phosphatase
Serum
Inflammatory Bowel Diseases
Fibrosis
9 Citations (Scopus)

Principles to promote physician satisfaction and work-life balance.

Shanafelt, T. D., West, C. P., Poland, G. A., La Russo, N. F., Menaker, R. & Bahn, R. S., Dec 2008, In : Minnesota Medicine. 91, 12, p. 41-43 3 p.

Research output: Contribution to journal › Article

Organizations
Delivery of Health Care
Physicians
Job Satisfaction
Medicine
7 Citations (Scopus)

Proceedings: Mechanism of action of chenodeoxycholic acid in gallstone dissolution.

Northfield, T. C., La Russo, N. F., Thistle, J. L. & Hofmann, A. F., Oct 1973, In : Gut. 14, 10, p. 826-827 2 p.

Research output: Contribution to journal › Article

Chenodeoxycholic Acid
Cholelithiasis
Gallstones
Bile Acids and Salts
Cholesterol
33 Citations (Scopus)

Processing of cholecystokinin by isolated liver cells

Gores, G. J., Kost, L. J., Miller, L. J. & La Russo, N. F., 1989, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 257, 2

Research output: Contribution to journal › Article

Cholecystokinin
Hepatocytes
Anions
Liver
Peptides
53 Citations (Scopus)

Prospective randomized comparison of mezlocillin therapy alone with combined ampicillin and gentamicin therapy for patients with cholangitis

Gerecht, W. B., Henry, N. K., Hoffman, W. W., Muller, S. M., La Russo, N. F., Rosenblatt, J. E. & Wilson, W. R., 1989, In : Archives of Internal Medicine. 149, 6, p. 1279-1284 6 p.

Research output: Contribution to journal › Article

Mezlocillin
Cholangitis
Ampicillin
Gentamicins
Poisons
141 Citations (Scopus)

Prospective trial of penicillamine in primary sclerosing cholangitis

La Russo, N. F., Wiesner, R. H., Ludwig, J., MacCarty, R. L., Beaver, S. J. & Zinsmeister, A. R., 1988, In : Gastroenterology. 95, 4, p. 1036-1042 7 p.

Research output: Contribution to journal › Article

Sclerosing Cholangitis
Penicillamine
Liver
Disease Progression
Survival
46 Citations (Scopus)

Proteins in bile: how they get there and what they do.

La Russo, N. F., Sep 1984, In : The American journal of physiology. 247, 3 Pt 1

Research output: Contribution to journal › Article

Bile
Proteins
Hepatocytes
Theoretical Models
Liver
45 Citations (Scopus)

Proteins in bile: How they get there and what they do

La Russo, N. F., 1984, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 10, 3

Research output: Contribution to journal › Article

Bile
Proteins
Hepatocytes
Theoretical Models
Liver
54 Citations (Scopus)

Proteolytic cleavage and nuclear translocation of fibrocystin is regulated by intracellular Ca2+ and activation of protein kinase C

Hiesberger, T., Gourley, E., Erickson, A., Koulen, P., Ward, C. J., Masyuk, T. V., La Russo, N. F., Harris, P. C. & Igarashi, P., Nov 10 2006, In : Journal of Biological Chemistry. 281, 45, p. 34357-34364 8 p.

Research output: Contribution to journal › Article

Proteolysis
Protein Kinase C
Autosomal Recessive Polycystic Kidney
Chemical activation
Nuclear Localization Signals
5 Citations (Scopus)

Purification and immunological quantification of rat liver lysosomal glycosidases

De Groen, P. C., LeSage, G. D., Tietz, P. S. & La Russo, N. F., 1989, In : Biochemical Journal. 264, 1, p. 115-123 9 p.

Research output: Contribution to journal › Article

Glycoside Hydrolases
Liver
Purification
Rats
Enzyme activity
4 Citations (Scopus)

Purification and partial characterization of a heat-resistant, cytosolic neuropeptidase from rat liver

Janas, R. M., Marks, D. L. & La Russo, N. F., 1994, In : Biochemical and Biophysical Research Communications. 198, 2, p. 574-581 8 p.

Research output: Contribution to journal › Article

Sincalide
Liver
Purification
Rats
Hot Temperature

Purification of lysosomes from guinea pig gastric mucosal cells by uptake of triton WR-1339

Madson, T. H., La Russo, N. F. & Dozois, R. R., 1981, In : Gastroenterology. 80, 5 II, p. 1221 1 p.

Research output: Contribution to journal › Article

Lysosomes
Stomach
Guinea Pigs
tyloxapol
43 Citations (Scopus)

Purinergic regulation of acid/base transport in human and rat biliary epithelial cell lines

Zsembery, Á., Spirl, C., Granato, A., La Russo, N. F., Okolicsanyi, L., Crepaldi, G. & Strazzabosco, M., 1998, In : Hepatology. 28, 4 I, p. 914-920 7 p.

Research output: Contribution to journal › Article

Adenosine Triphosphate
Epithelial Cells
Cell Line
Acids
Purinergic Agonists
47 Citations (Scopus)

Quantitative assessment of the rat intrahepatic biliary system by three-dimensional reconstruction

Masyuk, T. V., Ritman, E. L. & La Russo, N. F., 2001, In : American Journal of Pathology. 158, 6, p. 2079-2088 10 p.

Research output: Contribution to journal › Article

Biliary Tract
Bile Ducts
X-Ray Computed Tomography Scanners
Three-Dimensional Imaging
Liver
17 Citations (Scopus)

Quantitative importance of biliary excretion to the turnover of hepatic lysosomal enzymes

Nakano, A., Marks, D. L., Tietz, P. S., De Groen, P. C. & La Russo, N. F., 1995, In : Hepatology. 22, 1, p. 262-266 5 p.

Research output: Contribution to journal › Article

Bile
Liver
Enzymes
Hydrolases
Proteins
22 Citations (Scopus)

Rab3D, a small GTP-binding protein implicated in regulated secretion, is associated with the transcytotic pathway in rat hepatocytes

Larkin, J. M., Woo, B., Balan, V., Marks, D. L., Oswald, B. J., La Russo, N. F. & Mc Niven, M. A., 2000, In : Hepatology. 32, 2, p. 348-356 9 p.

Research output: Contribution to journal › Article

Transcytosis
Guanosine Triphosphate
Hepatocytes
Carrier Proteins
Cytoplasm
213 Citations (Scopus)

Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and liver disease

Hogan, M. C., Masyuk, T. V., Page, L. J., Kubly, V. J., Bergstralh, E. J., Li, X., Kim, B., King, B. F., Glockner, J., Holmes III, D. R., Rossetti, S., Harris, P. C., La Russo, N. F. & Torres, V., Jun 2010, In : Journal of the American Society of Nephrology. 21, 6, p. 1052-1061 10 p.

Research output: Contribution to journal › Article

Autosomal Dominant Polycystic Kidney
Octreotide
Somatostatin
Randomized Controlled Trials
Placebos
195 Citations (Scopus)

Rapid dissolution of gallstones by methyl tert-butyl ether. Preliminary observations

Allen, M. J., Borody, T. J., Bugliosi, T. F., May, G. R., La Russo, N. F. & Thistle, J. L., 1985, In : New England Journal of Medicine. 312, 4, p. 217-220 4 p.

Research output: Contribution to journal › Article

Intrahepatic Bile Ducts
Chenodeoxycholic Acid
Methyl Ethers
Ursodeoxycholic Acid
Drug Evaluation
202 Citations (Scopus)

Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter

Lazaridis, K. N., Pham, L., Tietz, P., Marinelli, R. A., DeGroen, P. C., Levine, S., Dawson, P. A. & La Russo, N. F., Dec 1 1997, In : Journal of Clinical Investigation. 100, 11, p. 2714-2721 8 p.

Research output: Contribution to journal › Article

Bile Acids and Salts
Taurocholic Acid
Liver
Transcytosis
sodium-bile acid cotransporter
56 Citations (Scopus)

Rat hepatocyte aquaporin-8 water channels are down-regulated in extrahepatic cholestasis

Carreras, F. I., Gradilone, S. A., Mazzone, A., García, F., Huang, B. Q., Ochoa, J. E., Tietz, P. S., La Russo, N. F., Calamita, G. & Marinelli, R. A., May 1 2003, In : Hepatology. 37, 5, p. 1026-1033 8 p.

Research output: Contribution to journal › Article

Extrahepatic Cholestasis
Aquaporins
Hepatocytes
Bile Ducts
Ligation
47 Citations (Scopus)

Rat hepatocytes transport water mainly via a non-channel-mediated pathway

Yano, M., Marinelli, R. A., Roberts, S. K., Balan, V., Pham, L., Tarara, J. E., De Groen, P. C. & La Russo, N. F., Mar 22 1996, In : Journal of Biological Chemistry. 271, 12, p. 6702-6707 6 p.

Research output: Contribution to journal › Article

Rats
Hepatocytes
Aquaporins
Water
Permeability
143 Citations (Scopus)

Recent advances in the isolation of liver cells

Alpini, G., Phillips, J. O., Vroman, B. & La Russo, N. F., Aug 1994, In : Hepatology. 20, 2, p. 494-514 21 p.

Research output: Contribution to journal › Article

Cell Separation
Liver
Myofibroblasts
Centrifugation
Dendritic Cells
21 Citations (Scopus)

Recent advances in the management of primary sclerosing cholangitis

Lindor, K. D., Wiesner, R. H. & La Russo, N. F., 1987, In : Seminars in Liver Disease. 7, 4, p. 322-327 6 p.

Research output: Contribution to journal › Article

Sclerosing Cholangitis
Biliary Tract
Choledocholithiasis
Cholangiocarcinoma
Cholangiography
264 Citations (Scopus)

Recurrence of primary sclerosing cholangitis following liver transplantation

Graziadei, I. W., Wiesner, R. H., Batts, K. P., Marotta, P. J., La Russo, N. F., Porayko, M. K., Eileen Hay, J., Gores, G. J., Charlton, M. R., Ludwig, J., Poterucha, J. J., Steers, J. L. & Krom, R. A. F., 1999, In : Hepatology. 29, 4, p. 1050-1056 7 p.

Research output: Contribution to journal › Article

Sclerosing Cholangitis
Liver Transplantation
Recurrence
Pathologic Constriction
Liver
18 Citations (Scopus)

Regulated vesicle trafficking of membrane transporters in hepatic epithelia

Marinelli, R. A., Tietz, P. S. & La Russo, N. F., Apr 2005, In : Journal of Hepatology. 42, 4, p. 592-603 12 p.

Research output: Contribution to journal › Article

Membrane Transport Proteins
Epithelium
Liver
64 Citations (Scopus)

Regulation of bicarbonate-dependent ductular bile secretion assessed by lumenal micropuncture of isolated rodent intrahepatic bile ducts

Roberts, S. K., Kuntz, S. M., Gores, G. J. & La Russo, N. F., Oct 1 1993, In : Proceedings of the National Academy of Sciences of the United States of America. 90, 19, p. 9080-9084 5 p.

Research output: Contribution to journal › Article

Intrahepatic Bile Ducts
Bicarbonates
Bile Ducts
Punctures
Bile
70 Citations (Scopus)

Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes

Schlenker, T., Romac, J. M. J., Sharara, A. I., Roman, R. M., Kim, S. J., La Russo, N. F., Liddle, R. A. & Gregory Fitz, J., 1997, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 273, 5 36-5

Research output: Contribution to journal › Article

Purinergic Receptors
Adenosine Triphosphate
Bile
4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid
Bumetanide
57 Citations (Scopus)

Regulation of Ca2+ signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms

Hirata, K., Dufour, J. F., Shibao, K., Knickelbein, R., O'Neill, A. F., Bode, H. P., Cassio, D., St-Pierre, M. V., La Russo, N. F., Leite, M. F. & Nathanson, M. H., 2002, In : Hepatology. 36, 2, p. 284-296 13 p.

Research output: Contribution to journal › Article

Inositol 1,4,5-Trisphosphate Receptors
Bile Ducts
Protein Isoforms
Epithelium
Ryanodine Receptor Calcium Release Channel
77 Citations (Scopus)

Release of Luminal Exosomes Contributes to TLR4-Mediated Epithelial Antimicrobial Defense

Hu, G., Gong, A. Y., Roth, A. L., Huang, B. Q., Ward, H. D., Zhu, G., La Russo, N. F., Hanson, N. D. & Chen, X. M., Apr 2013, In : PLoS Pathogens. 9, 4, e1003261.

Research output: Contribution to journal › Article

Exosomes
Cryptosporidium parvum
Sporozoites
Peptides
Epithelium

Reply

La Russo, N. F., 1994, In : Gastroenterology. 106, 3, p. 822 1 p.

Research output: Contribution to journal › Article

Reply to Otero and Szabo [2]

Huang, B. Q., Masyuk, T. V., Muff, M. A., Tietz, P. S., Masyuk, A. I. & La Russo, N. F., Jun 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 292, 6

Research output: Contribution to journal › Article

14 Citations (Scopus)

Research Productivity of Graduates from 3 Physician-Scientist Training Programs

Dyrbye, L. L., Lindor, K. D., La Russo, N. F. & Cook, D. A., Dec 2008, In : American Journal of Medicine. 121, 12, p. 1107-1113 7 p.

Research output: Contribution to journal › Article

Program Evaluation
Medical Education
Biomedical Research
Physicians
Education
15 Citations (Scopus)

Role for Krüppel-Like Transcription Factor 11 in Mesenchymal Cell Function and Fibrosis

Mathison, A., Grzenda, A., Lomberk, G., Velez, G., Buttar, N. S., Tietz, P., Hendrickson, H., Liebl, A., Xiong, Y. Y., Gores, G. J., Fernandez-Zapico, M. E., La Russo, N. F., Faubion, W. A., Shah, V. & Urrutia, R., Sep 16 2013, In : PLoS One. 8, 9, e75311.

Research output: Contribution to journal › Article

fibrosis
collagen
Fibrosis
Transcription Factors
Collagen
3 Citations (Scopus)

Role of the Intestinal Microbiome in Cholestatic Liver Disease

La Russo, N. F., Tabibian, J. H. & O'Hara, S. P., Mar 1 2017, In : Digestive Diseases. 35, 3, p. 166-168 3 p.

Research output: Contribution to journal › Article

Microbiota
Liver Diseases
Health
Epigenomics
Liver

Sampling intestinal content with a sequestering capsule. A noninvasive technique for determining bile acid kinetics in man

Hoffman, N. E., La Russo, N. F. & Hofmann, A. F., 1976, In : Mayo Clinic Proceedings. 51, 3, p. 171-175 5 p.

Research output: Contribution to journal › Article

Gastrointestinal Contents
Bile Acids and Salts
Capsules
Cholestyramine Resin
Chenodeoxycholic Acid
9 Citations (Scopus)

Sclerosing cholangitis

Marotta, P. J., La Russo, N. F. & Wiesner, R. H., Dec 1997, In : Bailliere's Clinical Gastroenterology. 11, 4, p. 781-800 20 p.

Research output: Contribution to journal › Article

Sclerosing Cholangitis
Biliary Liver Cirrhosis
Cholestasis
Biliary Tract
Portal Hypertension
2 Citations (Scopus)

Search for medical treatment for primary biliary cirrhosis

La Russo, N. F., 1997, In : Lancet. 350, 9084, p. 1046 1 p.

Research output: Contribution to journal › Article

Cholagogues and Choleretics
Ursodeoxycholic Acid
Biliary Liver Cirrhosis
Immunosuppressive Agents
Methotrexate
129 Citations (Scopus)

Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes

Marinelli, R. A., Tietz, P. S., Pham, L. D., Rueckert, L., Agre, P. & La Russo, N. F., Jan 1999, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 276, 1 39-1

Research output: Contribution to journal › Article

Aquaporin 1
Aquaporins
Secretin
Bile
Cell Membrane