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Nicholas F La Russo, MD

  • 27732 Citations
  • 95 Scopus h-Index
1973 …2020

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Research Output

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Article

Secretin stimulates exocytosis in isolated bile duct epithelial cells by a cyclic AMP-mediated mechanism

Kato, A., Gores, G. J. & LaRusso, N. F., Jan 1 1992, In : Journal of Biological Chemistry. 267, 22, p. 15523-15529 7 p.

Research output: Contribution to journal › Article

127 Scopus citations

Selection and timing of liver transplantation in primary biliary cirrhosis and primary sclerosing cholangitis

Wiesner, R. H., Porayko, M. K., Dickson, E. R., Gores, G. J., Larusso, N. F., Hay, J. E., Wahlstrom, H. E. & Krom, R. A. F., Nov 1992, In : Hepatology. 16, 5, p. 1290-1299 10 p.

Research output: Contribution to journal › Article

134 Scopus citations

Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis

Jorgensen, R. A., Lindor, K. D., Sartin, J. S., LaRusso, N. F. & Wiesner, R. H., Apr 1995, In : Journal of clinical gastroenterology. 20, 3, p. 215-219 5 p.

Research output: Contribution to journal › Article

61 Scopus citations

Simple method for simultaneous specific activity measurements in a mixture of radiolabeled bile acids

Belobaba, D. T. E., Carlson, G. L. & LaRusso, N. F., Apr 21 1979, In : Journal of Chromatography A. 172, 1, p. 410-416 7 p.

Research output: Contribution to journal › Article

2 Scopus citations

Solute and water transport pathways in cholangiocytes

Marinelli, R. A. & LaRusso, N. F., Jan 1 1996, In : Seminars in Liver Disease. 16, 2, p. 221-229 9 p.

Research output: Contribution to journal › Article

34 Scopus citations

Somatostatin analog therapy for severe polycystic liver disease: Results after 2 years

Hogan, M. C., Masyuk, T. V., Page, L., Holmes, D. R., Li, X., Bergstralh, E. J., Irazabal, M. V., Kim, B., King, B. F., Glockner, J. F., Larusso, N. F. & Torres, V. E., Sep 1 2012, In : Nephrology Dialysis Transplantation. 27, 9, p. 3532-3539 8 p.

Research output: Contribution to journal › Article

89 Scopus citations

Somatostatin inhibits secretin-induced ductal hypercholeresis and exocytosis by cholangiocytes

Tietz, P. S., Alpini, G., Pham, L. D. & LaRusso, N. F., Jan 1 1995, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 269, 1 32-1, p. G110-G118

Research output: Contribution to journal › Article

93 Scopus citations

Somatostatin receptor imaging in cholangiocarcinoma [1]

Jamar, F., Pauwels, S., Horsmans, Y., Deprez, P., Tan, C. K., Larusso, N. F. & Gores, G. J., Jan 1 1996, In : Gastroenterology. 110, 5, p. 1675-1676 2 p.

Research output: Contribution to journal › Article

Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes

Gong, A. Y., Tietz, P. S., Muff, M. A., Splinter, P. L., Huebert, R. C., Strowski, M. Z., Chen, X. M. & LaRusso, N. F., May 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 5 53-5, p. C1205-C1214

Research output: Contribution to journal › Article

52 Scopus citations

Specific inhibition of AQP1 water channels in isolated rat intrahepatic bile duct units by small interfering RNAs

Splinter, P. L., Masyuk, A. I. & LaRusso, N. F., Feb 21 2003, In : Journal of Biological Chemistry. 278, 8, p. 6268-6274 7 p.

Research output: Contribution to journal › Article

54 Scopus citations

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., Frantz, M. C., Bell-Temin, H., Pope-Varsalona, H., Gurkar, A. U., Nasto, L. A., Robinson, R. A. S., Fuhrmann-Stroissnigg, H., Czerwinska, J., McGowan, S. J., Cantu-Medellin, N. & 22 others, Harris, J. B., Maniar, S., Ross, M. A., Trussoni, C. E., LaRusso, N. F., Cifuentes-Pagano, E., Pagano, P. J., Tudek, B., Vo, N. V., Rigatti, L. H., Opresko, P. L., Stolz, D. B., Watkins, S. C., Burd, C. E., Croix, C. M. S., Siuzdak, G., Yates, N. A., Robbins, P. D., Wang, Y., Wipf, P., Kelley, E. E. & Niedernhofer, L. J., Jul 2018, In : Redox Biology. 17, p. 259-273 15 p.

Research output: Contribution to journal › Article

23 Scopus citations

Stimulation of ATP secretion in the liver by therapeutic bile acids

Nathanson, M. H., Burgstahler, A. D., Masyuk, A. & LaRusso, N. F., Aug 15 2001, In : Biochemical Journal. 358, 1, p. 1-5 5 p.

Research output: Contribution to journal › Article

62 Scopus citations

Strategies for improving attendance at medical grand rounds at an Academic Medical Center

Mueller, P. S., Litin, S. C., Sowden, M. L., Habermann, T. M. & LaRusso, N. F., May 1 2003, In : Mayo Clinic proceedings. 78, 5, p. 549-553 5 p.

Research output: Contribution to journal › Article

21 Scopus citations

Successful implementation of a telemedicine-based counseling program for high-risk patients with breast cancer

Pruthi, S., Stange, K. J., Malagrino, G. D., Chawla, K. S., LaRusso, N. F. & Kaur, J. S., Jan 2013, In : Mayo Clinic proceedings. 88, 1, p. 68-73 6 p.

Research output: Contribution to journal › Article

18 Scopus citations

Surreptitious laxative ingestion. Delayed recognition of a serious condition: a case report

LaRusso, N. F. & McGill, D. B., Dec 1 1975, In : Mayo Clinic proceedings. 50, 12, p. 706-708 3 p.

Research output: Contribution to journal › Article

21 Scopus citations

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice

Moncsek, A., Al-Suraih, M. S., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Zuber, C., Patsenker, E., Valli, P. V., Fingas, C. D., Weber, A., Zhu, Y., Tchkonia, T., Kirkland, J. L., Gores, G. J., Müllhaupt, B., La Russo, N. F. & Mertens, J. C., Jan 1 2018, In : Hepatology. 67, 1, p. 247-259 13 p.

Research output: Contribution to journal › Article

35 Scopus citations

T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis

Allina, J., Hu, B., Sullivan, D. M., Fiel, M. I., Thung, S. N., Bronk, S. F., Huebert, R. C., van de Water, J., LaRusso, N. F., Gershwin, M. E., Gores, G. J. & Odin, J. A., Dec 1 2006, In : Journal of Autoimmunity. 27, 4, p. 232-241 10 p.

Research output: Contribution to journal › Article

77 Scopus citations

Temporal elements in career selection decisions: An archival study investigating career decisions in medicine

Shah, P. P., Bechara, J. P., Kolars, J., Drefahl, M., LaRusso, N., Wood, D. & Spurrier, B., Jan 1 2014, In : Organization Science. 25, 1, p. 245-261 17 p.

Research output: Contribution to journal › Article

TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling

Masyuk, T. V., Masyuk, A. I., Lorenzo Pisarello, M., Howard, B. N., Huang, B. Q., Lee, P. Y., Fung, X., Sergienko, E., Ardecky, R. J., Chung, T. D. Y., Pinkerton, A. B. & La Russo, N. F., 2017, (Accepted/In press) In : Hepatology.

Research output: Contribution to journal › Article

10 Scopus citations

TGR5 in the cholangiociliopathies

Masyuk, T. V., Masyuk, A. I. & La Russo, N. F., Jun 9 2015, In : Digestive Diseases. 33, 3, p. 420-425 6 p.

Research output: Contribution to journal › Article

15 Scopus citations

The achilles’ heel of senescent cells: From transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O’hara, S. P., Larusso, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., Lebrasseur, N. K., Wren, J. D., Farr, J. N., Khosla, S., Stout, M. B. & 13 others, McGowan, S. J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Zhao, J., Colangelo, D., Dorronsoro, A., Ling, Y. Y., Barghouthy, A. S., Navarro, D. C., Sano, T., Robbins, P. D., Niedernhofer, L. J. & Kirkland, J. L., Jan 1 2015, In : Aging Cell. 14, 4, p. 644-658 15 p.

Research output: Contribution to journal › Article

502 Scopus citations

The AGA Institute: A Professional Society With a Social Conscience

LaRusso, N. F., Dec 2008, In : Gastroenterology. 135, 6, p. e12-e13

Research output: Contribution to journal › Article

The "age" factor in adult medicine

Tefferi, A. & LaRusso, N. F., Jul 1 2003, In : Mayo Clinic proceedings. 78, 7, 1 p.

Research output: Contribution to journal › Article

4 Scopus citations

The application of design principles to innovate clinical care delivery.

Brennan, M. D., Duncan, A. K., Armbruster, R. R., Montori, V. M., Feyereisn, W. L. & LaRusso, N. F., Jan 1 2009, In : Journal for healthcare quality : official publication of the National Association for Healthcare Quality. 31, 1, p. 5-9 5 p.

Research output: Contribution to journal › Article

5 Scopus citations

The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD)

Banales, J. M., Masyuk, T. V., Gradilone, S. A., Masyuk, A. I., Medina, J. F. & LaRusso, N. F., Mar 9 2009, In : Hepatology. 49, 1, p. 160-174 15 p.

Research output: Contribution to journal › Article

85 Scopus citations

The cholangiopathies: Disorders of biliary epithelia

Lazaridis, K. N., Strazzabosco, M. & Larusso, N. F., Nov 2004, In : Gastroenterology. 127, 5, p. 1565-1577 13 p.

Research output: Contribution to journal › Article

266 Scopus citations

The cholangiopathies

Lazaridis, K. N. & La Russo, N. F., Jun 1 2015, In : Mayo Clinic Proceedings. 90, 6, p. 791-800 10 p.

Research output: Contribution to journal › Article

96 Scopus citations

The Combination of Prednisone and Colchicine in Patients with Primary Sclerosing Cholangitis

Lindor, K. D., Wiesner, R. H., Colwell, L. JO., Steiner, B., Beaver, S. & LaRusso, N. F., Jan 1991, In : The American Journal of Gastroenterology. 86, 1, p. 57-61 5 p.

Research output: Contribution to journal › Article

119 Scopus citations

The enteric microbiome in hepatobiliary health and disease

Tabibian, J. H., Varghese, C., Larusso, N. F. & O'Hara, S. P., Apr 1 2016, In : Liver International. 36, 4, p. 480-487 8 p.

Research output: Contribution to journal › Article

18 Scopus citations

The human immunodeficiency virus type 1 Tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism

O'Hara, S. P., Small, A. J., Nelson, J. B., Badley, A. D., Chen, X. M., Gores, G. J. & LaRusso, N. F., Feb 1 2007, In : Infection and Immunity. 75, 2, p. 684-696 13 p.

Research output: Contribution to journal › Article

15 Scopus citations

The ins and outs of membrane movement in biliary epithelia.

LaRusso, N. F., Ishii, M. & Vroman, B. T., 1990, In : Transactions of the American Clinical and Climatological Association. 102, p. 245-258; discussion 258-259

Research output: Contribution to journal › Article

8 Scopus citations

The isolated perfused rat liver: Conceptual and practical considerations

Gores, G. J., Kost, L. J. & Larusso, N. F., Jan 1 1986, In : Hepatology. 6, 3, p. 511-517 7 p.

Research output: Contribution to journal › Article

249 Scopus citations

The liver and intracellular digestion: How liver cells eat!

Yamazaki, K. & Larusso, N. F., Nov 1989, In : Hepatology. 10, 5, p. 877-886 10 p.

Research output: Contribution to journal › Article

22 Scopus citations

The metabolic bone disease of primary sclerosing cholangitis

Hay, J. E., Lindor, K. D., Wiesner, R. H., Dickson, E. R., Krom, R. A. F. & Larusso, N. F., Aug 1991, In : Hepatology. 14, 2, p. 257-261 5 p.

Research output: Contribution to journal › Article

100 Scopus citations

The pathobiology of biliary epithelia

Roberts, S. K., Ludwig, J. & LaRusso, N. F., Jan 1 1997, In : Gastroenterology. 112, 1, p. 269-279 11 p.

Research output: Contribution to journal › Article

108 Scopus citations

The pathobiology of biliary epithelia

Alpini, G., McGill, J. M. & LaRusso, N. F., Jan 1 2002, In : Hepatology. 35, 5, p. 1256-1268 13 p.

Research output: Contribution to journal › Article

115 Scopus citations

The relative role of the Child-Pugh classification and the Mayo natural history model in the assessment of survival in patients with primary sclerosing cholangitis

Kim, W. R., Poterucha, J. J., Wiesner, R. H., LaRusso, N. F., Lindor, K. D., Petz, J., Therneau, T. M., Malinchoc, M. & Dickson, E. R., Jun 7 1999, In : Hepatology. 29, 6, p. 1643-1648 6 p.

Research output: Contribution to journal › Article

104 Scopus citations

The role of cilia in the regulation of bile flow

Larusso, N. F. & Masyuk, T. V., Jun 1 2011, In : Digestive Diseases. 29, 1, p. 6-12 7 p.

Research output: Contribution to journal › Article

21 Scopus citations

The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1

O'Hara, S. P., Splinter, P. L., Trussoni, C. E., Guicciardi, M. E., Splinter, N. P., Al Suraih, M. S., Nasser-Ghodsi, N., Stollenwerk, D., Gores, G. J. & LaRusso, N. F., Dec 6 2019, In : Journal of Biological Chemistry. 294, 49, p. 18698-18713 16 p.

Research output: Contribution to journal › Article

1 Scopus citations

The utility of CA 19-9 in the diagnoses of cholangiocarcinoma in patients without primary sclerosing cholangitis

Patel, A. H., Harnois, D. M., Klee, G. G., Larusso, N. F. & Gores, G. J., Jan 1 2000, In : American Journal of Gastroenterology. 95, 1, p. 204-207 4 p.

Research output: Contribution to journal › Article

296 Scopus citations

The value of serum CA 19-9 in predicting cholangiocarcinomas in patients with primary sclerosing cholangitis

Levy, C., Lymp, J., Angulo, P., Gores, G. J., Larusso, N. & Lindor, K. D., Sep 1 2005, In : Digestive diseases and sciences. 50, 9, p. 1734-1740 7 p.

Research output: Contribution to journal › Article

217 Scopus citations

The Water Channel Aquaporin-8 is Mainly Intracellular in Rat Hepatocytes, and its Plasma Membrane Insertion is Stimulated by Cyclic AMP

García, F., Kierbel, A., Larocca, M. C., Gradilone, S. A., Splinter, P., LaRusso, N. F. & Marinelli, R. A., Apr 13 2001, In : Journal of Biological Chemistry. 276, 15, p. 12147-12152 6 p.

Research output: Contribution to journal › Article

171 Scopus citations

The zebrafish as a model to study polycystic liver disease

Tietz Bogert, P. S., Huang, B. Q., Gradilone, S. A., Masyuk, T. V., Moulder, G. L., Ekker, S. C. & Larusso, N. F., Jun 1 2013, In : Zebrafish. 10, 2, p. 211-217 7 p.

Research output: Contribution to journal › Article

10 Scopus citations

Time course of histological progression in primary sclerosing cholangitis

Angulo, P., Larson, D. R., Therneau, T. M., Larusso, N. F., Batts, K. P. & Lindor, K. D., Nov 1 1999, In : American Journal of Gastroenterology. 94, 11, p. 3310-3313 4 p.

Research output: Contribution to journal › Article

52 Scopus citations

Time-dependent effects of chloroquine on pH of hepatocyte lysosomes

Tietz, P. S., Yamazaki, K. & Larusso, N. F., Sep 15 1990, In : Biochemical Pharmacology. 40, 6, p. 1419-1421 3 p.

Research output: Contribution to journal › Article

20 Scopus citations

TLR4 promotes cryptosporidium parvum clearance in a mouse model of biliary cryptosporidiosis

O'Hara, S. P., Tietz Bogert, P. S., Trussoni, C. E., Chen, X. & Larusso, N. F., Oct 1 2011, In : Journal of Parasitology. 97, 5, p. 813-821 9 p.

Research output: Contribution to journal › Article

23 Scopus citations

Triton WR‐1339, A Lysosomotropic Compound, Is Excreted into Bile and Alters the Biliary Excretion of Lysosomal Enzymes and Lipids

Larusso, N. F., Kost, L. J., Carter, J. A. & Barham, S. S., Jan 1 1982, In : Hepatology. 2, 2, p. 209S-215S

Research output: Contribution to journal › Article

28 Scopus citations

Triton WR-1339 is excreted into bile and alters the biliary excretion of lipids and proteins

LaRusso, N. F., Kost, L. J., Carter, J. & Barham, S., Jan 1 1981, In : Gastroenterology. 80, 5 II, 1 p.

Research output: Contribution to journal › Article

Ulcerative colitis disease activity following treatment of associated primary sclerosing cholangitis with cyclosporin

Sandborn, W. J., Wiesner, R. H., Tremaine, W. J. & Larusso, N. F., Feb 1993, In : Gut. 34, 2, p. 242-246 5 p.

Research output: Contribution to journal › Article

Open Access
55 Scopus citations

Up-regulation of microRNA 506 leads to decreased Cl -/HCO 3 - anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis

Banales, J. M., Sáez, E., Úriz, M., Sarvide, S., Urribarri, A. D., Splinter, P., Tietz Bogert, P. S., Bujanda, L., Prieto, J., Medina, J. F. & Larusso, N. F., Aug 1 2012, In : Hepatology. 56, 2, p. 687-697 11 p.

Research output: Contribution to journal › Article

124 Scopus citations