• 26935 Citations
  • 93 Scopus h-Index
1973 …2019
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Research Output 1973 2019

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Article
2006
80 Citations (Scopus)

Engineered measles virus as a novel oncolytic viral therapy system for hepatocellular carcinoma

Blechacz, B., Splinter, P. L., Greiner, S., Myers, R., Peng, K-W., Federspiel, M. J., Russell, S. J. & La Russo, N. F., Dec 2006, In : Hepatology. 44, 6, p. 1465-1477 13 p.

Research output: Contribution to journalArticle

Measles virus
Hepatocellular Carcinoma
Viruses
Carcinoembryonic Antigen
Cell Line
61 Citations (Scopus)

Isolation and characterization of cholangiocyte primary cilia

Huang, B. Q., Masyuk, T. V., Muff, M. A., Tietz, P. S., Masyuk, A. I. & La Russo, N. F., 2006, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 291, 3

Research output: Contribution to journalArticle

Cilia
Bile Ducts
Organelles
Far-Western Blotting
Liver
62 Citations (Scopus)

Isolation and characterization of lipid microdomains from apical and basolateral plasma membranes of rat hepatocytes

Mazzone, A., Tietz, P., Jefferson, J., Pagano, R. & La Russo, N. F., Feb 2006, In : Hepatology. 43, 2, p. 287-296 10 p.

Research output: Contribution to journalArticle

Hepatocytes
Cell Membrane
Lipids
Detergents
Caveolin 1
30 Citations (Scopus)

Polycystic liver disease: New insights into disease pathogenesis

Masyuk, T. & La Russo, N. F., May 2006, In : Hepatology. 43, 5, p. 906-908 3 p.

Research output: Contribution to journalArticle

Cysts
Liver Diseases
Polycystic liver disease
200 Citations (Scopus)

Primary sclerosing cholangitis: Summary of a workshop

La Russo, N. F., Shneider, B. L., Black, D., Gores, G. J., James, S. P., Doo, E. & Hoofnagle, J. H., Sep 2006, In : Hepatology. 44, 3, p. 746-764 19 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Education
Liver Transplantation
Cholangiocarcinoma
Survival
54 Citations (Scopus)

Proteolytic cleavage and nuclear translocation of fibrocystin is regulated by intracellular Ca2+ and activation of protein kinase C

Hiesberger, T., Gourley, E., Erickson, A., Koulen, P., Ward, C. J., Masyuk, T. V., La Russo, N. F., Harris, P. C. & Igarashi, P., Nov 10 2006, In : Journal of Biological Chemistry. 281, 45, p. 34357-34364 8 p.

Research output: Contribution to journalArticle

Proteolysis
Protein Kinase C
Autosomal Recessive Polycystic Kidney
Chemical activation
Nuclear Localization Signals
76 Citations (Scopus)

T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis

Allina, J., Hu, B., Sullivan, D. M., Fiel, M. I., Thung, S. N., Bronk, S. F., Huebert, R. C., van de Water, J., La Russo, N. F., Gershwin, M. E., Gores, G. J. & Odin, J. A., Dec 2006, In : Journal of Autoimmunity. 27, 4, p. 232-241 10 p.

Research output: Contribution to journalArticle

Cytophagocytosis
Biliary Liver Cirrhosis
Autoantigens
Epithelial Cells
Phagocytosis
2007
70 Citations (Scopus)

{A figure is presented}The Utility of Lens Culinaris Agglutinin-Reactive α-Fetoprotein in the Diagnosis of Hepatocellular Carcinoma: Evaluation in a United States Referral Population

Leerapun, A., Suravarapu, S. V., Bida, J. P., Clark, R. J., Sanders, E. L., Mettler, T. A., Stadheim, L. M., Aderca, I., Moser, C. D., Nagorney, D. M., La Russo, N. F., de Groen, P. C., Menon, K. V. N., Lazaridis, K. N., Gores, G. J., Charlton, M. R., Roberts, R. O., Therneau, T. M., Katzmann, J. A. & Roberts, L. R., Mar 2007, In : Clinical Gastroenterology and Hepatology. 5, 3, p. 394-402 9 p.

Research output: Contribution to journalArticle

Fetal Proteins
Hepatocellular Carcinoma
Referral and Consultation
Population
lentil lectin
330 Citations (Scopus)

A cellular micro-RNA, let-7i, regulates toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection

Chen, X. M., Splinter, P. L., O'Hara, S. P. & La Russo, N. F., Sep 28 2007, In : Journal of Biological Chemistry. 282, 39, p. 28929-28938 10 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Toll-Like Receptor 4
MicroRNAs
Toll-Like Receptors
Infection
68 Citations (Scopus)

A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation

Woollard, J. R., Punyashtiti, R., Richardson, S., Masyuk, T. V., Whelan, S., Huang, B. Q., Lager, D. J., Van Deursen, J., Torres, V., Gattone, V. H., La Russo, N. F., Harris, P. C. & Ward, C. J., Aug 2007, In : Kidney International. 72, 3, p. 328-336 9 p.

Research output: Contribution to journalArticle

Autosomal Recessive Polycystic Kidney
Dilatation
Kidney
Bile Ducts
Liver
36 Citations (Scopus)

Cholangiocyte biology

Bogert, P. T. & La Russo, N. F., May 2007, In : Current Opinion in Gastroenterology. 23, 3, p. 299-305 7 p.

Research output: Contribution to journalArticle

Technology
Investigational Therapies
Cholestasis
Ion Transport
Gene Silencing
127 Citations (Scopus)

Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion

Gradilone, S. A., Masyuk, A. I., Splinter, P. L., Banales, J. M., Huang, B. Q., Tietz, P. S., Masyuk, T. V. & La Russo, N. F., Nov 27 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 48, p. 19138-19143 6 p.

Research output: Contribution to journalArticle

Cilia
Bicarbonates
Bile
Adenosine Triphosphate
Intrahepatic Bile Ducts
92 Citations (Scopus)

Cyclic AMP Regulates Bicarbonate Secretion in Cholangiocytes Through Release of ATP Into Bile

Minagawa, N., Nagata, J., Shibao, K., Masyuk, A. I., Gomes, D. A., Rodrigues, M. A., Lesage, G., Akiba, Y., Kaunitz, J. D., Ehrlich, B. E., La Russo, N. F. & Nathanson, M. H., Nov 2007, In : Gastroenterology. 133, 5, p. 1592-1602 11 p.

Research output: Contribution to journalArticle

Bicarbonates
Bile
Cyclic AMP
Intrahepatic Bile Ducts
Adenosine Triphosphate
24 Citations (Scopus)
Teaching Rounds
physician
Prospective Studies
food
Physicians
91 Citations (Scopus)
Tight Junctions
Lipopolysaccharides
Occludin
Genistein
Permeability
192 Citations (Scopus)
Octreotide
Polycystic Kidney Diseases
Adenosine
Rodentia
Autosomal Recessive Polycystic Kidney

Reply to Otero and Szabo [2]

Huang, B. Q., Masyuk, T. V., Muff, M. A., Tietz, P. S., Masyuk, A. I. & La Russo, N. F., Jun 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 292, 6

Research output: Contribution to journalArticle

15 Citations (Scopus)

The human immunodeficiency virus type 1 Tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism

O'Hara, S. P., Small, A. J., Nelson, J. B., Badley, A. D., Chen, X. M., Gores, G. J. & La Russo, N. F., Feb 2007, In : Infection and Immunity. 75, 2, p. 684-696 13 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Fas Ligand Protein
Trans-Activators
HIV-1
Apoptosis
2008
5 Citations (Scopus)

Cholangiocyte bile salt transporters in cholesterol gallstone-susceptible and resistant inbred mouse strains

Liu, J. J., Glickman, J. N., Masyuk, A. I. & La Russo, N. F., 2008, In : Journal of Gastroenterology and Hepatology (Australia). 23, 10, p. 1596-1602 7 p.

Research output: Contribution to journalArticle

Inbred Strains Mice
Gallstones
Bile Acids and Salts
Cholesterol
Inbred AKR Mouse
105 Citations (Scopus)

Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors

Masyuk, A. I., Gradilone, S. A., Banales, J. M., Huang, B. Q., Masyuk, T. V., Lee, S. O., Splinter, P. L., Stroope, A. J. & La Russo, N. F., Oct 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 4

Research output: Contribution to journalArticle

Purinergic P2Y12 Receptors
Cilia
Organelles
Nucleotides
Intrahepatic Bile Ducts
87 Citations (Scopus)

Cholangiocyte primary cilia in liver health and disease

Masyuk, A. I., Masyuk, T. V. & La Russo, N. F., Aug 2008, In : Developmental Dynamics. 237, 8, p. 2007-2012 6 p.

Research output: Contribution to journalArticle

Cilia
Liver Diseases
Health
Intrahepatic Bile Ducts
Mutation
51 Citations (Scopus)

Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease

Banales, J. M., Masyuk, T. V., Bogert, P. S., Huang, B. Q., Gradilone, S. A., Lee, S. O., Stroope, A. J., Masyuk, A. I., Medina, J. F. & La Russo, N. F., Dec 2008, In : American Journal of Pathology. 173, 6, p. 1637-1646 10 p.

Research output: Contribution to journalArticle

Autosomal Recessive Polycystic Kidney
Polycystic Kidney Diseases
Aquaporins
Ion Channels
Cysts
9 Citations (Scopus)

Host cell actin remodeling in response to Cryptosporidium.

O'Hara, S. P., Small, A. J., Chen, X. M. & La Russo, N. F., 2008, In : Sub-Cellular Biochemistry. 47, p. 92-100 9 p.

Research output: Contribution to journalArticle

Cryptosporidium
Actins
Parasites
Host-Pathogen Interactions
Pathogens
123 Citations (Scopus)

MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease

Lee, S. O., Masyuk, T., Splinter, P., Banales, J. M., Masyuk, A., Stroope, A. & La Russo, N. F., Nov 3 2008, In : Journal of Clinical Investigation. 118, 11, p. 3714-3724 11 p.

Research output: Contribution to journalArticle

Polycystic Kidney Diseases
Cell Cycle
MicroRNAs
Liver
Cell Proliferation
25 Citations (Scopus)

Pathobiology of biliary epithelia and cholangiocarcinoma: Proceedings of the Henry M. and Lillian Stratton Basic Research Single-Topic Conference

Sirica, A. E., Nathanson, M. H., Gores, G. J. & La Russo, N. F., 2008, In : Hepatology. 48, 6, p. 2040-2046 7 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Posters
Epithelium
Research
Critical Pathways
9 Citations (Scopus)

Principles to promote physician satisfaction and work-life balance.

Shanafelt, T. D., West, C. P., Poland, G. A., La Russo, N. F., Menaker, R. & Bahn, R. S., Dec 2008, In : Minnesota Medicine. 91, 12, p. 41-43 3 p.

Research output: Contribution to journalArticle

Organizations
Delivery of Health Care
Physicians
Job Satisfaction
Medicine
14 Citations (Scopus)

Research Productivity of Graduates from 3 Physician-Scientist Training Programs

Dyrbye, L. L., Lindor, K. D., La Russo, N. F. & Cook, D. A., Dec 2008, In : American Journal of Medicine. 121, 12, p. 1107-1113 7 p.

Research output: Contribution to journalArticle

Program Evaluation
Medical Education
Biomedical Research
Physicians
Education
10 Citations (Scopus)

Standardized care processes to improve quality and safety of patient care in a large academic practice: The Plummer Project of the Department of Medicine, Mayo Clinic

Wood, D. L., Brennan, M. D., Chaudhry, R., Chihak, A. A., Feyereisn, W. L., Woychick, N. L., Hagen, P. T., Curtright, J. W., Naessens, J. M., Spurrier, B. R. & La Russo, N. F., 2008, In : Health Services Management Research. 21, 4, p. 276-280 5 p.

Research output: Contribution to journalArticle

Patient Care
Medicine
Physicians
Safety
Biomedical Enhancement

The AGA Institute: A Professional Society With a Social Conscience

La Russo, N. F., Dec 2008, In : Gastroenterology. 135, 6

Research output: Contribution to journalArticle

50 Citations (Scopus)

The immunobiology of cholangiocytes

Chen, X. M., O'Hara, S. P. & La Russo, N. F., Aug 2008, In : Immunology and Cell Biology. 86, 6, p. 497-505 9 p.

Research output: Contribution to journalArticle

Liver
Biliary Tract
Immunity
Mucosal Immunity
Kupffer Cells
2009
188 Citations (Scopus)

Characterization of PKD protein-positive exosome-like vesicles

Hogan, M. C., Manganelli, L., Woollard, J. R., Masyuk, A. I., Masyuk, T. V., Tammachote, R., Huang, B. Q., Leontovich, A. A., Beito, T. G., Madden, B. J., Charlesworth, M. C., Torres, V., La Russo, N. F., Harris, P. C. & Ward, C. J., Feb 2009, In : Journal of the American Society of Nephrology. 20, 2, p. 278-288 11 p.

Research output: Contribution to journalArticle

Exosomes
Cilia
Proteomics
Proteins
Autosomal Recessive Polycystic Kidney
59 Citations (Scopus)

Cholangiociliopathies: Genetics, molecular mechanisms and potential therapies

Masyuk, T., Masyuk, A. & La Russo, N. F., May 2009, In : Current Opinion in Gastroenterology. 25, 3, p. 265-271 7 p.

Research output: Contribution to journalArticle

Molecular Biology
Cysts
Liver
MicroRNAs
Therapeutics
20 Citations (Scopus)

HIV-1 tat protein suppresses cholangiocyte toll- like receptor 4 expression and defense against cryptosporidium parvum

O'Hara, S. P., Small, A. J., Gajdos, G. B., Badley, A. D., Chen, X. M. & La Russo, N. F., Apr 15 2009, In : Journal of Infectious Diseases. 199, 8, p. 1195-1204 10 p.

Research output: Contribution to journalArticle

tat Gene Products
Cryptosporidium parvum
Toll-Like Receptor 4
HIV-1
Cryptosporidiosis
6 Citations (Scopus)

Isolation of primary cilia for morphological analysis.

Huang, B., Masyuk, T. & La Russo, N. F., 2009, In : Methods in Cell Biology. 94, p. 103-115 13 p.

Research output: Contribution to journalArticle

Cilia
Cultured Cells
Epithelial Cells
Transmission Electron Microscopy
Confocal Microscopy
206 Citations (Scopus)

MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3

Selaru, F. M., Olaru, A. V., Kan, T., David, S., Cheng, Y., Mori, Y., Yang, J., Paun, B., Jin, Z., Agarwal, R., Hamilton, J. P., Abraham, J., Georgiades, C., Alvarez, H., Vivekanandan, P., Yu, W., Maitra, A., Torbenson, M., Thuluvath, P. J., Gores, G. J. & 3 others, La Russo, N. F., Hruban, R. & Meltzer, S. J., May 2009, In : Hepatology. 49, 5, p. 1595-1601 7 p.

Research output: Contribution to journalArticle

Tissue Inhibitor of Metalloproteinase-3
Cholangiocarcinoma
MicroRNAs
Cell Death
Reverse Transcriptase Polymerase Chain Reaction
128 Citations (Scopus)

MicroRNA-513 regulates B7-H1 translation and is involved in IFN-γ-induced B7-H1 expression in cholangiocytes

Gong, A. Y., Zhou, R., Hu, G., Li, X., Splinter, P. L., O'Hara, S. P., La Russo, N. F., Soukup, G. A., Dong, H. M. & Chen, X. M., Feb 1 2009, In : Journal of Immunology. 182, 3, p. 1325-1333 9 p.

Research output: Contribution to journalArticle

MicroRNAs
3' Untranslated Regions
Transfection
Proteins
B7 Antigens
71 Citations (Scopus)

MicroRNAs: Key Modulators of Posttranscriptional Gene Expression

O'Hara, S. P., Mott, J. L., Splinter, P. L., Gores, G. J. & La Russo, N. F., Jan 2009, In : Gastroenterology. 136, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

Gastrointestinal Neoplasms
Gene Expression Regulation
MicroRNAs
Cell Differentiation
Cell Cycle
17 Citations (Scopus)

MicroRNAs in cholangiociliopathies

Masyuk, T., Masyuk, A. & La Russo, N. F., May 1 2009, In : Cell Cycle. 8, 9, p. 1324-1328 5 p.

Research output: Contribution to journalArticle

MicroRNAs
Cell Cycle
Fluids and Secretions
Calcium Signaling
Liver
5 Citations (Scopus)

The application of design principles to innovate clinical care delivery.

Brennan, M. D., Duncan, A. K., Armbruster, R. R., Montori, V. M., Feyereisn, W. L. & La Russo, N. F., Jan 2009, In : Journal for healthcare quality : official publication of the National Association for Healthcare Quality. 31, 1, p. 5-9 5 p.

Research output: Contribution to journalArticle

National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
Delivery of Health Care
Research
Manufacturing Industry
Clinical Studies
82 Citations (Scopus)

The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD)

Banales, J. M., Masyuk, T. V., Gradilone, S. A., Masyuk, A. I., Medina, J. F. & La Russo, N. F., 2009, In : Hepatology. 49, 1, p. 160-174 15 p.

Research output: Contribution to journalArticle

Autosomal Recessive Polycystic Kidney
Cyclic AMP
Protein Kinases
Animal Models
Liver
2010
58 Citations (Scopus)

Activation of Trpv4 Reduces the Hyperproliferative Phenotype of Cystic Cholangiocytes From an Animal Model of ARPKD

Gradilone, S. A., Masyuk, T. V., Huang, B. Q., Banales, J. M., Lehmann, G. L., Radtke, B. N., Stroope, A., Masyuk, A. I., Splinter, P. L. & La Russo, N. F., Jul 2010, In : Gastroenterology. 139, 1

Research output: Contribution to journalArticle

Autosomal Recessive Polycystic Kidney
TRPV Cation Channels
Polycystic Kidney Diseases
Animal Models
Phenotype
38 Citations (Scopus)

Aquaporin-1 facilitates angiogenic invasion in the pathological neovasculature that accompanies cirrhosis

Huebert, R. C., Vasdev, M. M., Shergill, U., Das, A., Huang, B. Q., Charlton, M. R., La Russo, N. F. & Shah, V., Jul 2010, In : Hepatology. 52, 1, p. 238-248 11 p.

Research output: Contribution to journalArticle

Aquaporin 1
Fibrosis
Blister
Liver
Endothelial Cells
145 Citations (Scopus)

Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia

Masyuk, A. I., Huang, B. Q., Ward, C. J., Gradilone, S. A., Banales, J. M., Masyuk, T. V., Radtke, B., Splinter, P. L. & La Russo, N. F., Oct 2010, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 299, 4

Research output: Contribution to journalArticle

Exosomes
Cilia
Bile
Intrahepatic Bile Ducts
Immunoelectron Microscopy
9 Citations (Scopus)

Cholangiocyte myosin IIB is required for localized aggregation of sodium glucose cotransporter 1 to sites of Cryptosporidium parvum cellular invasion and facilitates parasite internalization

O'Hara, S. P., Gajdos, G. B., Trussoni, C. E., Splinter, P. L. & La Russo, N. F., Jul 2010, In : Infection and Immunity. 78, 7, p. 2927-2936 10 p.

Research output: Contribution to journalArticle

Sodium-Glucose Transporter 1
Nonmuscle Myosin Type IIB
Cryptosporidium parvum
Parasites
Cell Surface Extensions
20 Citations (Scopus)

Hepato-renal pathology in Pkd2ws25/- mice, an animal model of autosomal dominant polycystic kidney disease

Stroope, A., Radtke, B., Huang, B., Masyuk, T., Torres, V., Ritman, E. & La Russo, N. F., Mar 2010, In : American Journal of Pathology. 176, 3, p. 1282-1291 10 p.

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Animal Models
Pathology
Kidney
Liver
37 Citations (Scopus)

Immortalized liver endothelial cells: A cell culture model for studies of motility and angiogenesis

Huebert, R. C., Jagavelu, K., Liebl, A. F., Huang, B. Q., Splinter, P. L., La Russo, N. F., Urrutia, R. A. & Shah, V., Dec 2010, In : Laboratory Investigation. 90, 12, p. 1770-1781 12 p.

Research output: Contribution to journalArticle

Endothelial Cells
Cell Culture Techniques
Liver
Pseudopodia
Endocytosis
82 Citations (Scopus)

NFκB p50-CCAAT/enhancer-binding protein β (C/EBPβ)-mediated transcriptional repression of microRNA let-7i following microbial infection

O'Hara, S. P., Splinter, P. L., Gajdos, G. B., Trussoni, C. E., Fernandez-Zapico, M. E., Chen, X. M. & La Russo, N. F., Jan 1 2010, In : Journal of Biological Chemistry. 285, 1, p. 216-225 10 p.

Research output: Contribution to journalArticle

CCAAT-Enhancer-Binding Proteins
MicroRNAs
Infection
Cryptosporidium parvum
Toll-Like Receptor 4
42 Citations (Scopus)

Opisthorchis viverrini excretory/secretory products induce toll-like receptor 4 upregulation and production of interleukin 6 and 8 in cholangiocyte

Ninlawan, K., O'Hara, S. P., Splinter, P. L., Yongvanit, P., Kaewkes, S., Surapaitoon, A., La Russo, N. F. & Sripa, B., Dec 2010, In : Parasitology International. 59, 4, p. 616-621 6 p.

Research output: Contribution to journalArticle

Opisthorchis
Toll-Like Receptor 4
Interleukin-8
Interleukin-6
Up-Regulation
214 Citations (Scopus)

Randomized clinical trial of long-acting somatostatin for autosomal dominant polycystic kidney and liver disease

Hogan, M. C., Masyuk, T. V., Page, L. J., Kubly, V. J., Bergstralh, E. J., Li, X., Kim, B., King, B. F., Glockner, J., Holmes III, D. R., Rossetti, S., Harris, P. C., La Russo, N. F. & Torres, V., Jun 2010, In : Journal of the American Society of Nephrology. 21, 6, p. 1052-1061 10 p.

Research output: Contribution to journalArticle

Autosomal Dominant Polycystic Kidney
Octreotide
Somatostatin
Randomized Controlled Trials
Placebos
2011
37 Citations (Scopus)

Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive MicroRNAs

Huebert, R. C., Jagavelu, K., Hendrickson, H. I., Vasdev, M. M., Arab, J. P., Splinter, P. L., Trussoni, C. E., La Russo, N. F. & Shah, V., Oct 2011, In : American Journal of Pathology. 179, 4, p. 1851-1860 10 p.

Research output: Contribution to journalArticle

Aquaporin 1
Portal Hypertension
MicroRNAs
Fibrosis
Bile Ducts