• 26831 Citations
  • 93 Scopus h-Index
1973 …2019
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Research Output 1973 2019

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2003
48 Citations (Scopus)

ATP binding cassette transporter gene expression in rat liver progenitor cells

Ros, J. E., Roskams, T. A. D., Geuken, M., Havinga, R., Splinter, P. L., Petersen, B. E., La Russo, N. F., Van Der Kolk, D. M., Kuipers, F., Faber, K. N., Müller, M. & Jansen, P. L. M., Jul 1 2003, In : Gut. 52, 7, p. 1060-1067 8 p.

Research output: Contribution to journalArticle

ATP-Binding Cassette Transporters
Hepatocytes
Stem Cells
Gene Expression
Liver
227 Citations (Scopus)

Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia

Ward, C. J., Yuan, D., Masyuk, T. V., Wang, X., Punyashthiti, R., Whelan, S., Bacallao, R., Torra, R., La Russo, N. F., Torres, V. & Harris, P. C., Oct 15 2003, In : Human Molecular Genetics. 12, 20, p. 2703-2710 8 p.

Research output: Contribution to journalArticle

Autosomal Recessive Polycystic Kidney
Cilia
Proteins
Kidney
Monoclonal Antibodies
8 Citations (Scopus)

Centers, institutes, and the future of clinical departments: Part II.

Crist, T. B., La Russo, N. F., Meyers, F. J., Clayton, C. P. & Ibrahim, T., Dec 15 2003, In : The American journal of medicine. 115, 9, p. 745-747 3 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

Centers, Institutes, and the future of clinical departments: part I.

Ibrahim, T., O'Connell, J. B., La Russo, N. F., Meyers, F. J. & Crist, T. B., Sep 2003, In : The American journal of medicine. 115, 4, p. 337-341 5 p.

Research output: Contribution to journalArticle

Interdepartmental Relations
Hospital Departments
Internal Medicine
Decision Making
1 Citation (Scopus)

Cholangiocyte biology

Tietz, P. & La Russo, N. F., May 2003, In : Current Opinion in Gastroenterology. 19, 3, p. 264-269 6 p.

Research output: Contribution to journalArticle

Ion Transport
Gene Silencing
Cytoskeleton
Knockout Mice
Liver Diseases
56 Citations (Scopus)

Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src

Chen, X. M., Huang, B. Q., Splinter, P. L., Cao, H., Zhu, G., Mc Niven, M. A. & La Russo, N. F., Jul 1 2003, In : Gastroenterology. 125, 1, p. 216-228 13 p.

Research output: Contribution to journalArticle

Cortactin
Cryptosporidium parvum
Tyrosine
Epithelium
Phosphorylation
100 Citations (Scopus)

Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes

Spirlì, C., Fabris, L., Duner, E., Fiorotto, R., Ballardini, G., Roskams, T., La Russo, N. F., Sonzogni, A., Okolicsanyi, L. & Strazzabosco, M., Mar 1 2003, In : Gastroenterology. 124, 3, p. 737-753 17 p.

Research output: Contribution to journalArticle

Adenylyl Cyclases
Cyclic AMP
Nitric Oxide
Cytokines
Cholestasis
136 Citations (Scopus)

Defects in Cholangiocyte Fibrocystin Expression and Ciliary Structure in the PCK Rat

Masyuk, T. V., Huang, B. Q., Ward, C. J., Masyuk, A. I., Yuan, D., Splinter, P. L., Punyashthiti, R., Ritman, E. L., Torres, V., Harris, P. C. & La Russo, N. F., Nov 2003, In : Gastroenterology. 125, 5, p. 1303-1310 8 p.

Research output: Contribution to journalArticle

Cilia
Intrahepatic Bile Ducts
Small Interfering RNA
Polycystic Kidney Diseases
Cysts
70 Citations (Scopus)

Glucagon induces the plasma membrane insertion of functional aquaporin-8 water channels in isolated rat hepatocytes

Gradilone, S. A., García, F., Huebert, R. C., Tietz, P. S., Larocca, M. C., Kierbel, A., Carreras, F. I., La Russo, N. F. & Marinelli, R. A., Jun 1 2003, In : Hepatology. 37, 6, p. 1435-1441 7 p.

Research output: Contribution to journalArticle

Aquaporins
Glucagon
Hepatocytes
Cell Membrane
Permeability
42 Citations (Scopus)

Hepatic artery and portal vein remodeling in rat liver: Vascular response to selective cholangiocyte proliferation

Masyuk, T. V., Ritman, E. L. & La Russo, N. F., Apr 1 2003, In : American Journal of Pathology. 162, 4, p. 1175-1182 8 p.

Research output: Contribution to journalArticle

Hepatic Veins
Hepatic Artery
Portal Vein
Blood Vessels
Liver
6 Citations (Scopus)

Improving attendance at medical grand rounds (multiple letters)

Kuo, D., Klainer, A. S., Reinharth, D., Dhatariya, K., Mueller, P., Litin, S. C., Sowden, M. L., Habermann, T. M. & La Russo, N. F., Jul 1 2003, In : Mayo Clinic Proceedings. 78, 7, p. 922-923 2 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Rat hepatocyte aquaporin-8 water channels are down-regulated in extrahepatic cholestasis

Carreras, F. I., Gradilone, S. A., Mazzone, A., García, F., Huang, B. Q., Ochoa, J. E., Tietz, P. S., La Russo, N. F., Calamita, G. & Marinelli, R. A., May 1 2003, In : Hepatology. 37, 5, p. 1026-1033 8 p.

Research output: Contribution to journalArticle

Extrahepatic Cholestasis
Aquaporins
Hepatocytes
Bile Ducts
Ligation
51 Citations (Scopus)

Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes

Gong, A. Y., Tietz, P. S., Muff, M. A., Splinter, P. L., Huebert, R. C., Strowski, M. Z., Chen, X. M. & La Russo, N. F., May 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 5 53-5

Research output: Contribution to journalArticle

Somatostatin
Intrahepatic Bile Ducts
Bile
Ducts
Secretin
52 Citations (Scopus)

Specific inhibition of AQP1 water channels in isolated rat intrahepatic bile duct units by small interfering RNAs

Splinter, P. L., Masyuk, A. I. & La Russo, N. F., Feb 21 2003, In : Journal of Biological Chemistry. 278, 8, p. 6268-6274 7 p.

Research output: Contribution to journalArticle

Intrahepatic Bile Ducts
Aquaporins
Ducts
Small Interfering RNA
Rats
20 Citations (Scopus)

Strategies for improving attendance at medical grand rounds at an Academic Medical Center

Mueller, P., Litin, S. C., Sowden, M. L., Habermann, T. M. & La Russo, N. F., May 1 2003, In : Mayo Clinic Proceedings. 78, 5, p. 549-553 5 p.

Research output: Contribution to journalArticle

Teaching Rounds
Needs Assessment
Tertiary Healthcare
Research Personnel
4 Citations (Scopus)

The "age" factor in adult medicine

Tefferi, A. & La Russo, N. F., Jul 1 2003, In : Mayo Clinic Proceedings. 78, 7, p. 913 1 p.

Research output: Contribution to journalArticle

Age Factors
Medicine
56 Citations (Scopus)

Water Transporting Properties of Hepatocyte Basolateral and Canalicular Plasma Membrane Domains

Marinelli, R. A., Tietz, P. S., Caride, A. J., Huang, B. Q. & La Russo, N. F., Oct 31 2003, In : Journal of Biological Chemistry. 278, 44, p. 43157-43162 6 p.

Research output: Contribution to journalArticle

Cell membranes
Hepatocytes
Cell Membrane
Aquaporins
Water
2002
2 Citations (Scopus)

A learner-centered academic career development curriculum.

McDonald, F. S., Schultz, H. J. & La Russo, N. F., May 2002, In : Academic medicine : journal of the Association of American Medical Colleges. 77, 5, p. 463 1 p.

Research output: Contribution to journalArticle

Staff Development
Medical Faculties
academic career
curriculum development
Internship and Residency
19 Citations (Scopus)

A novel incentive system for faculty in an academic medical center

Brandt, T. L., Romme, C. R., La Russo, N. F. & Lindor, K. D., Nov 5 2002, In : Annals of Internal Medicine. 137, 9, p. 738-743 6 p.

Research output: Contribution to journalArticle

Motivation
Physicians
Efficiency
Health Services Accessibility
Aptitude
19 Citations (Scopus)

Channel-mediated water movement across enclosed or perfused mouse intrahepatic bile duct units

Gong, A. Y., Masyuk, A. I., Splinter, P. L., Huebert, R. C., Tietz, P. S. & La Russo, N. F., 2002, In : American Journal of Physiology - Cell Physiology. 283, 1 52-1

Research output: Contribution to journalArticle

Water Movements
Intrahepatic Bile Ducts
Ducts
Water
Aquaporins
2 Citations (Scopus)

Cholangiocyte biology

Tietz, P. & La Russo, N. F., 2002, In : Current Opinion in Gastroenterology. 18, 3, p. 360-365 6 p.

Research output: Contribution to journalArticle

Bile Ducts
Biliary Tract
Bile
Theoretical Models
Software
339 Citations (Scopus)

Cryptosporidiosis

Chen, X. M., Keithly, J. S., Paya, C. V. & La Russo, N. F., May 30 2002, In : New England Journal of Medicine. 346, 22, p. 1723-1731 9 p.

Research output: Contribution to journalArticle

AIDS-Related Opportunistic Infections
Cryptosporidiosis
Anti-HIV Agents
Cryptosporidium
41 Citations (Scopus)

Cryptosporidiosis and the pathogenesis of AIDS-cholangiopathy

Chen, X. M. & La Russo, N. F., Aug 2002, In : Seminars in Liver Disease. 22, 3, p. 277-289 13 p.

Research output: Contribution to journalArticle

Cryptosporidiosis
Acquired Immunodeficiency Syndrome
Cryptosporidium
Biliary Tract
Epithelium
9 Citations (Scopus)

Experimental models to study cholangiocyte biology

Tietz, P. S., Chen, X. M., Gong, A. Y., Huebert, R. C., Masyuk, A., Masyuk, T., Splinter, P. L. & La Russo, N. F., 2002, In : World Journal of Gastroenterology. 8, 1, p. 1-4 4 p.

Research output: Contribution to journalArticle

Bile Ducts
Theoretical Models
Cryptosporidium parvum
Biliary Tract
Bile
119 Citations (Scopus)

Expression and localization of aquaporin water channels in rat hepatocytes. Evidence for a role in canalicular bile secretion

Huebert, R. C., Splinter, P. L., Garcia, F., Marinelli, R. A. & La Russo, N. F., Jun 21 2002, In : Journal of Biological Chemistry. 277, 25, p. 22710-22717 8 p.

Research output: Contribution to journalArticle

Aquaporins
Bile
Rats
Hepatocytes
Cell membranes
3 Citations (Scopus)
Biological Transport
Cell Polarity
Cell membranes
Bile Ducts
Actins
127 Citations (Scopus)

In primary sclerosing cholangitis, gallbladder polyps are frequently malignant

Buckles, D. C., Lindor, K. D., La Russo, N. F., Petrovic, L. M. & Gores, G. J., 2002, In : American Journal of Gastroenterology. 97, 5, p. 1138-1142 5 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Polyps
Gallbladder
Cholecystectomy
Gallbladder Neoplasms
34 Citations (Scopus)

Intrahepatic bile ducts transport water in response to absorbed glucose

Masyuk, A. I., Masyuk, T. V., Tietz, P. S., Splinter, P. L. & La Russo, N. F., Sep 2002, In : American Journal of Physiology - Cell Physiology. 283, 3 52-3

Research output: Contribution to journalArticle

Intrahepatic Bile Ducts
Ducts
Glucose
Water
Bile
13 Citations (Scopus)

Optimization of a research web environment for academic internal medicine faculty

Elkin, P. L., Sorensen, B., De Palo, D., Poland, G., Bailey, K. R., Wood, D. L. & La Russo, N. F., Sep 2002, In : Journal of the American Medical Informatics Association. 9, 5, p. 472-478 7 p.

Research output: Contribution to journalArticle

Internal Medicine
Research
Research Personnel
Informatics
Human Engineering
49 Citations (Scopus)

Pirfenidone in the treatment of primary sclerosing cholangitis

Angulo, P., MacCarty, R. L., Sylvestre, P. B., Jorgensen, R. A., Wiesner, R. H., La Russo, N. F. & Lindor, K. D., 2002, In : Digestive Diseases and Sciences. 47, 1, p. 157-161 5 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Biochemistry
Liver
Therapeutics
Cholangiography
57 Citations (Scopus)

Regulation of Ca2+ signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms

Hirata, K., Dufour, J. F., Shibao, K., Knickelbein, R., O'Neill, A. F., Bode, H. P., Cassio, D., St-Pierre, M. V., La Russo, N. F., Leite, M. F. & Nathanson, M. H., 2002, In : Hepatology. 36, 2, p. 284-296 13 p.

Research output: Contribution to journalArticle

Inositol 1,4,5-Trisphosphate Receptors
Bile Ducts
Protein Isoforms
Epithelium
Ryanodine Receptor Calcium Release Channel
112 Citations (Scopus)

The pathobiology of biliary epithelia

Alpini, G., McGill, J. M. & La Russo, N. F., 2002, In : Hepatology. 35, 5, p. 1256-1268 13 p.

Research output: Contribution to journalArticle

Epithelium
Biliary Liver Cirrhosis
Bile Ducts
Bile
Inflammation Mediators
94 Citations (Scopus)

Water transport by epithelia of the digestive tract

Masyuk, A. I., Marinelli, R. A. & La Russo, N. F., 2002, In : Gastroenterology. 122, 2, p. 545-562 18 p.

Research output: Contribution to journalArticle

Gastrointestinal Tract
Epithelium
Water
2001
175 Citations (Scopus)

Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis

Odin, J. A., Huebert, R. C., Casciola-Rosen, L., La Russo, N. F. & Rosen, A., 2001, In : Journal of Clinical Investigation. 108, 2, p. 223-232 10 p.

Research output: Contribution to journalArticle

Biliary Liver Cirrhosis
Autoantigens
Pyruvic Acid
Oxidoreductases
Autoantibodies
93 Citations (Scopus)

Cryptosporidium parvum activates nuclear factor κB in biliary epithelia preventing epithelial cell apoptosis

Chen, X. M., Levine, S. A., Splinter, P. L., Tietz, P. S., Ganong, A. L., Jobin, C., Gores, G. J., Paya, C. V. & La Russo, N. F., 2001, In : Gastroenterology. 120, 7, p. 1774-1783 10 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
NF-kappa B
Epithelium
Epithelial Cells
Apoptosis
1 Citation (Scopus)

Erratum: Human Oggl, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide (Cancer Research (September 1, 2001) (6388-6393))

Jaiswal, M., La Russo, N. F., Nishioka, K., Nakabeppu, Y. & Gores, G. J., Oct 15 2001, In : Cancer Research. 61, 20, p. 7705 1 p.

Research output: Contribution to journalArticle

Nitric Oxide
Research
Neoplasms
Proteins
8-hydroxyguanine
196 Citations (Scopus)

High-dose ursodeoxycholic acid as a therapy for patients with primary sclerosing cholangitis

Harnois, D., Angulo, P., Jorgensen, R. A., La Russo, N. F. & Lindor, K. D., May 2001, In : American Journal of Gastroenterology. 96, 5, p. 1558-1562 5 p.

Research output: Contribution to journalArticle

Ursodeoxycholic Acid
Sclerosing Cholangitis
Placebos
Survival
Therapeutics
152 Citations (Scopus)

Human Ogg1, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide

Jaiswal, M., La Russo, N. F., Nishioka, N., Nakabeppu, Y. & Gores, G. J., Aug 1 2001, In : Cancer Research. 61, 17, p. 6388-6393 6 p.

Research output: Contribution to journalArticle

DNA Repair
Nitric Oxide
Proteins
S-Nitrosothiols
Inflammation
230 Citations (Scopus)
Nitric Oxide
Carcinogenesis
Epithelial Cells
Inflammation
Neoplasms
150 Citations (Scopus)

Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes

Jaiswal, M., La Russo, N. F., Shapiro, R. A., Billiar, T. R. & Gores, G. J., 2001, In : Gastroenterology. 120, 1, p. 190-199 10 p.

Research output: Contribution to journalArticle

DNA Repair
DNA Damage
Nitric Oxide
Nitric Oxide Synthase Type II
Biliary Tract Diseases
83 Citations (Scopus)

Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia

Dranoff, J. A., Masyuk, A. I., Kruglov, E. A., La Russo, N. F. & Nathanson, M. H., 2001, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 281, 4 44-4

Research output: Contribution to journalArticle

Purinergic P2 Receptors
Bile Ducts
Bile
Intrahepatic Bile Ducts
Epithelium
47 Citations (Scopus)

Quantitative assessment of the rat intrahepatic biliary system by three-dimensional reconstruction

Masyuk, T. V., Ritman, E. L. & La Russo, N. F., 2001, In : American Journal of Pathology. 158, 6, p. 2079-2088 10 p.

Research output: Contribution to journalArticle

Biliary Tract
Bile Ducts
X-Ray Computed Tomography Scanners
Three-Dimensional Imaging
Liver
62 Citations (Scopus)

Stimulation of ATP secretion in the liver by therapeutic bile acids

Nathanson, M. H., Burgstahler, A. D., Masyuk, A. & La Russo, N. F., Aug 15 2001, In : Biochemical Journal. 358, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Liver
Adenosine Triphosphate
Bile
Ursodeoxycholic Acid
169 Citations (Scopus)

The Water Channel Aquaporin-8 is Mainly Intracellular in Rat Hepatocytes, and its Plasma Membrane Insertion is Stimulated by Cyclic AMP

García, F., Kierbel, A., Larocca, M. C., Gradilone, S. A., Splinter, P., La Russo, N. F. & Marinelli, R. A., Apr 13 2001, In : Journal of Biological Chemistry. 276, 15, p. 12147-12152 6 p.

Research output: Contribution to journalArticle

Aquaporins
Cell membranes
Cyclic AMP
Rats
Hepatocytes
12 Citations (Scopus)

Upregulation of secretin receptors on cholangiocytes after bile duct ligation

Tietz, P. S., Hadac, E. M., Miller, L. J. & La Russo, N. F., Feb 2 2001, In : Regulatory Peptides. 97, 1, p. 1-6 6 p.

Research output: Contribution to journalArticle

Bile Ducts
Ducts
Ligation
Up-Regulation
Rats
31 Citations (Scopus)

Water movement across rat bile duct units is transcellular and channel-mediated

Cova, E., Gong, A. Y., Marinelli, R. A. & La Russo, N. F., 2001, In : Hepatology. 34, 3, p. 456-463 8 p.

Research output: Contribution to journalArticle

Water Movements
Aquaporins
Bile Ducts
Colforsin
Dimethyl Sulfoxide
2000
1 Citation (Scopus)

Academic internal medicine: challenges and opportunities - Part II

Costa, S. T., Brater, D. C., Coughlin, J. R., Danoff, D., Goode, L. D., Hazzard, W. R., La Russo, N. F., Matherlee, K. R., Spurrier, B. R. & Stolp-Smith, S. C., 2000, In : American Journal of Medicine. 108, 7, p. 601-608 8 p.

Research output: Contribution to journalArticle

Quality of Health Care
Internal Medicine
Medical Schools
Teaching Hospitals
Genetic Therapy
96 Citations (Scopus)
Alternative Splicing
Bile Acids and Salts
Sodium
Ileum
Hepatocytes
70 Citations (Scopus)

A pilot study of pentoxifylline for the treatment of primary sclerosing cholangitis

Bharucha, A. E., Jorgensen, R., Lichtman, S. N., La Russo, N. F. & Lindor, K. D., 2000, In : American Journal of Gastroenterology. 95, 9, p. 2338-2342 5 p.

Research output: Contribution to journalArticle

Pentoxifylline
Sclerosing Cholangitis
Tumor Necrosis Factor Receptors
Serum
Therapeutics
242 Citations (Scopus)

A revised natural history model for primary sclerosing cholangitis

Kim, W. R., Therneau, T. M., Wiesner, R. H., Poterucha, J. J., Benson, J. T., Malinchoc, M., La Russo, N. F., Lindor, K. D. & Dickson, E. R., 2000, In : Mayo Clinic Proceedings. 75, 7, p. 688-694 7 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Natural History
Survival
Aspartate Aminotransferases
Bilirubin