• 26846 Citations
  • 93 Scopus h-Index
1973 …2019
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Research Output 1973 2019

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2008

The AGA Institute: A Professional Society With a Social Conscience

La Russo, N. F., Dec 2008, In : Gastroenterology. 135, 6

Research output: Contribution to journalArticle

50 Citations (Scopus)

The immunobiology of cholangiocytes

Chen, X. M., O'Hara, S. P. & La Russo, N. F., Aug 2008, In : Immunology and Cell Biology. 86, 6, p. 497-505 9 p.

Research output: Contribution to journalArticle

Liver
Biliary Tract
Immunity
Mucosal Immunity
Kupffer Cells
2007
69 Citations (Scopus)

{A figure is presented}The Utility of Lens Culinaris Agglutinin-Reactive α-Fetoprotein in the Diagnosis of Hepatocellular Carcinoma: Evaluation in a United States Referral Population

Leerapun, A., Suravarapu, S. V., Bida, J. P., Clark, R. J., Sanders, E. L., Mettler, T. A., Stadheim, L. M., Aderca, I., Moser, C. D., Nagorney, D. M., La Russo, N. F., de Groen, P. C., Menon, K. V. N., Lazaridis, K. N., Gores, G. J., Charlton, M. R., Roberts, R. O., Therneau, T. M., Katzmann, J. A. & Roberts, L. R., Mar 2007, In : Clinical Gastroenterology and Hepatology. 5, 3, p. 394-402 9 p.

Research output: Contribution to journalArticle

Fetal Proteins
Hepatocellular Carcinoma
Referral and Consultation
Population
lentil lectin
328 Citations (Scopus)

A cellular micro-RNA, let-7i, regulates toll-like receptor 4 expression and contributes to cholangiocyte immune responses against Cryptosporidium parvum infection

Chen, X. M., Splinter, P. L., O'Hara, S. P. & La Russo, N. F., Sep 28 2007, In : Journal of Biological Chemistry. 282, 39, p. 28929-28938 10 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Toll-Like Receptor 4
MicroRNAs
Toll-Like Receptors
Infection
66 Citations (Scopus)

A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation

Woollard, J. R., Punyashtiti, R., Richardson, S., Masyuk, T. V., Whelan, S., Huang, B. Q., Lager, D. J., Van Deursen, J., Torres, V., Gattone, V. H., La Russo, N. F., Harris, P. C. & Ward, C. J., Aug 2007, In : Kidney International. 72, 3, p. 328-336 9 p.

Research output: Contribution to journalArticle

Autosomal Recessive Polycystic Kidney
Dilatation
Kidney
Bile Ducts
Liver
36 Citations (Scopus)

Cholangiocyte biology

Bogert, P. T. & La Russo, N. F., May 2007, In : Current Opinion in Gastroenterology. 23, 3, p. 299-305 7 p.

Research output: Contribution to journalArticle

Technology
Investigational Therapies
Cholestasis
Ion Transport
Gene Silencing
127 Citations (Scopus)

Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion

Gradilone, S. A., Masyuk, A. I., Splinter, P. L., Banales, J. M., Huang, B. Q., Tietz, P. S., Masyuk, T. V. & La Russo, N. F., Nov 27 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 48, p. 19138-19143 6 p.

Research output: Contribution to journalArticle

Cilia
Bicarbonates
Bile
Adenosine Triphosphate
Intrahepatic Bile Ducts
90 Citations (Scopus)

Cyclic AMP Regulates Bicarbonate Secretion in Cholangiocytes Through Release of ATP Into Bile

Minagawa, N., Nagata, J., Shibao, K., Masyuk, A. I., Gomes, D. A., Rodrigues, M. A., Lesage, G., Akiba, Y., Kaunitz, J. D., Ehrlich, B. E., La Russo, N. F. & Nathanson, M. H., Nov 2007, In : Gastroenterology. 133, 5, p. 1592-1602 11 p.

Research output: Contribution to journalArticle

Bicarbonates
Bile
Cyclic AMP
Intrahepatic Bile Ducts
Adenosine Triphosphate
24 Citations (Scopus)
Teaching Rounds
physician
Prospective Studies
food
Physicians
91 Citations (Scopus)
Tight Junctions
Lipopolysaccharides
Occludin
Genistein
Permeability
189 Citations (Scopus)
Octreotide
Polycystic Kidney Diseases
Adenosine
Rodentia
Autosomal Recessive Polycystic Kidney

Reply to Otero and Szabo [2]

Huang, B. Q., Masyuk, T. V., Muff, M. A., Tietz, P. S., Masyuk, A. I. & La Russo, N. F., Jun 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 292, 6

Research output: Contribution to journalArticle

15 Citations (Scopus)

The human immunodeficiency virus type 1 Tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism

O'Hara, S. P., Small, A. J., Nelson, J. B., Badley, A. D., Chen, X. M., Gores, G. J. & La Russo, N. F., Feb 2007, In : Infection and Immunity. 75, 2, p. 684-696 13 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Fas Ligand Protein
Trans-Activators
HIV-1
Apoptosis
2006
57 Citations (Scopus)

Aquaporins in the hepatobiliary system

Masyuk, A. I. & La Russo, N. F., Feb 2006, In : Hepatology. 43, 2 SUPPL. 1

Research output: Contribution to journalArticle

Aquaporins
Gluconeogenesis
Liver
Biliary Tract
Bile
54 Citations (Scopus)

Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis: Summary statement of a First National Institutes of Health/Office of Rare Diseases conference

Gunay-Aygun, M., Avner, E. D., Bacallao, R. L., Choyke, P. L., Flynn, J. T., Germino, G. G., Guay-Woodford, L., Harris, P. C., Heller, T., Ingelfinger, J., Kaskel, F., Kleta, R., La Russo, N. F., Mohan, P., Pazour, G. J., Shneider, B. L., Torres, V., Wilson, P., Zak, C., Zhou, J. & 1 others, Gahl, W. A., Aug 2006, In : Journal of Pediatrics. 149, 2, p. 159-164 6 p.

Research output: Contribution to journalArticle

Autosomal Recessive Polycystic Kidney
Distal Kidney Tubule
Anticholesteremic Agents
Proximal Kidney Tubule
Phosphoric Diester Hydrolases
17 Citations (Scopus)

Cholangiocyte biology

Tietz, P. S. & La Russo, N. F., May 2006, In : Current Opinion in Gastroenterology. 22, 3, p. 279-287 9 p.

Research output: Contribution to journalArticle

Technology
Cholestasis
Ion Transport
Gene Silencing
Bile
178 Citations (Scopus)

Cholangiocyte Cilia Detect Changes in Luminal Fluid Flow and Transmit Them Into Intracellular Ca2+ and cAMP Signaling

Masyuk, A. I., Masyuk, T. V., Splinter, P. L., Huang, B. Q., Stroope, A. J. & La Russo, N. F., Sep 2006, In : Gastroenterology. 131, 3, p. 911-920 10 p.

Research output: Contribution to journalArticle

Cilia
Intrahepatic Bile Ducts
Bile
Organelles
Protein Isoforms
17 Citations (Scopus)

Cloning and expression of SLC10A4, a putative organic anion transport protein

Splinter, P. L., Lazaridis, K. N., Dawson, P. A. & La Russo, N. F., Nov 14 2006, In : World Journal of Gastroenterology. 12, 42, p. 6797-6805 9 p.

Research output: Contribution to journalArticle

Organic Anion Transporters
CHO Cells
Organism Cloning
Taurocholic Acid
Tissue Distribution
28 Citations (Scopus)

Cryptosporidium parvum infects human cholangiocytes via sphingolipid-enriched membrane microdomains

Nelson, J. B., O'hara, S. P., Small, A. J., Tietz, P. S., Choudhury, A. K., Pagano, R. E., Chen, X. M. & La Russo, N. F., Dec 2006, In : Cellular Microbiology. 8, 12, p. 1932-1945 14 p.

Research output: Contribution to journalArticle

Membrane Microdomains
Cryptosporidium parvum
Sphingolipids
Membranes
Sphingomyelin Phosphodiesterase
23 Citations (Scopus)

Cytoskeletal and motor proteins facilitate trafficking of AQP1-containing vesicles in cholangiocytes

Tietz, P. S., Mc Niven, M. A., Splinter, P. L., Huang, B. Q. & La Russo, N. F., Jan 2006, In : Biology of the Cell. 98, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

Aquaporin 1
Cytoskeletal Proteins
Protein Transport
Dyneins
Kinesin
28 Citations (Scopus)

Development and characterization of a cholangiocyte cell line from the PCK rat, an animal model of Autosomal Recessive Polycystic Kidney Disease

Muff, M. A., Masyuk, T. V., Stroope, A. J., Huang, B. Q., Splinter, P. L., Lee, S. O. & La Russo, N. F., Sep 5 2006, In : Laboratory Investigation. 86, 9, p. 940-950 11 p.

Research output: Contribution to journalArticle

Autosomal Recessive Polycystic Kidney
Animal Models
Cell Line
Cysts
Cilia
80 Citations (Scopus)

Engineered measles virus as a novel oncolytic viral therapy system for hepatocellular carcinoma

Blechacz, B., Splinter, P. L., Greiner, S., Myers, R., Peng, K-W., Federspiel, M. J., Russell, S. J. & La Russo, N. F., Dec 2006, In : Hepatology. 44, 6, p. 1465-1477 13 p.

Research output: Contribution to journalArticle

Measles virus
Hepatocellular Carcinoma
Viruses
Carcinoembryonic Antigen
Cell Line
61 Citations (Scopus)

Isolation and characterization of cholangiocyte primary cilia

Huang, B. Q., Masyuk, T. V., Muff, M. A., Tietz, P. S., Masyuk, A. I. & La Russo, N. F., 2006, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 291, 3

Research output: Contribution to journalArticle

Cilia
Bile Ducts
Organelles
Far-Western Blotting
Liver
62 Citations (Scopus)

Isolation and characterization of lipid microdomains from apical and basolateral plasma membranes of rat hepatocytes

Mazzone, A., Tietz, P., Jefferson, J., Pagano, R. & La Russo, N. F., Feb 2006, In : Hepatology. 43, 2, p. 287-296 10 p.

Research output: Contribution to journalArticle

Hepatocytes
Cell Membrane
Lipids
Detergents
Caveolin 1
30 Citations (Scopus)

Polycystic liver disease: New insights into disease pathogenesis

Masyuk, T. & La Russo, N. F., May 2006, In : Hepatology. 43, 5, p. 906-908 3 p.

Research output: Contribution to journalArticle

Cysts
Liver Diseases
Polycystic liver disease
200 Citations (Scopus)

Primary sclerosing cholangitis: Summary of a workshop

La Russo, N. F., Shneider, B. L., Black, D., Gores, G. J., James, S. P., Doo, E. & Hoofnagle, J. H., Sep 2006, In : Hepatology. 44, 3, p. 746-764 19 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Education
Liver Transplantation
Cholangiocarcinoma
Survival
54 Citations (Scopus)

Proteolytic cleavage and nuclear translocation of fibrocystin is regulated by intracellular Ca2+ and activation of protein kinase C

Hiesberger, T., Gourley, E., Erickson, A., Koulen, P., Ward, C. J., Masyuk, T. V., La Russo, N. F., Harris, P. C. & Igarashi, P., Nov 10 2006, In : Journal of Biological Chemistry. 281, 45, p. 34357-34364 8 p.

Research output: Contribution to journalArticle

Proteolysis
Protein Kinase C
Autosomal Recessive Polycystic Kidney
Chemical activation
Nuclear Localization Signals
76 Citations (Scopus)

T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis

Allina, J., Hu, B., Sullivan, D. M., Fiel, M. I., Thung, S. N., Bronk, S. F., Huebert, R. C., van de Water, J., La Russo, N. F., Gershwin, M. E., Gores, G. J. & Odin, J. A., Dec 2006, In : Journal of Autoimmunity. 27, 4, p. 232-241 10 p.

Research output: Contribution to journalArticle

Cytophagocytosis
Biliary Liver Cirrhosis
Autoantigens
Epithelial Cells
Phagocytosis
2005
42 Citations (Scopus)

Aquaporin-8 is involved in water transport in isolated superficial colonocytes from rat proximal colon

Laforenza, U., Cova, E., Gastaldi, G., Tritto, S., Grazioli, M., La Russo, N. F., Splinter, P. L., D'Adamo, P., Tosco, M. & Ventura, U., Oct 2005, In : Journal of Nutrition. 135, 10, p. 2329-2336 8 p.

Research output: Contribution to journalArticle

aquaporins
colon
Colon
Water Movements
Aquaporin 3
2 Citations (Scopus)

Cholangiocyte biology

Tietz, P. S. & La Russo, N. F., May 2005, In : Current Opinion in Gastroenterology. 21, 3, p. 337-343 7 p.

Research output: Contribution to journalArticle

Bile
Technology
Theoretical Models
Cholestasis
Ion Transport
8 Citations (Scopus)

Distribution of Cryptosporidium parvum sporozoite apical organelles during attachment to and internalization by cultured biliary epithelial cells

O'Hara, S. P., Huang, B. Q., Chen, X. M., Nelson, J. & La Russo, N. F., Oct 2005, In : Journal of Parasitology. 91, 5, p. 995-999 5 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Sporozoites
sporozoites
Organelles
organelles
2 Citations (Scopus)

Examining the increased IgM production and ursodeoxycholic acid treatment in PBC

Lazaridis, K. N. & La Russo, N. F., Feb 2005, In : Gastroenterology. 128, 2, p. 498-500 3 p.

Research output: Contribution to journalArticle

Cholagogues and Choleretics
Immunologic Memory
Ursodeoxycholic Acid
Biliary Liver Cirrhosis
Immunoglobulin M
27 Citations (Scopus)

Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line, WIF-B

Gradilone, S. A., Tietz, P. S., Splinter, P. L., Marinelli, R. A. & La Russo, N. F., Aug 18 2005, In : BMC Physiology. 5

Research output: Contribution to journalArticle

Aquaporins
Hepatocytes
Cell Line
Bile
B-Lymphocytes
68 Citations (Scopus)

Localized glucose and water influx facilitates Cryptosporidium parvum cellular invasion by means of modulation of host-cell membrane protrusion

Chen, X. M., O'Hara, S. P., Huang, B. Q., Splinter, P. L., Nelson, J. B. & La Russo, N. F., May 3 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 18, p. 6338-6343 6 p.

Research output: Contribution to journalArticle

Cell Surface Extensions
Cryptosporidium parvum
Aquaporin 1
Actins
Glucose
46 Citations (Scopus)

Membrane microdomains in hepatocytes: Potential target areas for proteins involved in canalicular bile secretion

Tietz, P., Jefferson, J., Pagano, R. & La Russo, N. F., 2005, In : Journal of Lipid Research. 46, 7, p. 1426-1432 7 p.

Research output: Contribution to journalArticle

Membrane Microdomains
Sphingolipids
Bile
Hepatocytes
Membranes
147 Citations (Scopus)

Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-κB

Chen, X. M., O'Hara, S. P., Nelson, J. B., Splinter, P. L., Small, A. J., Tietz, P. S., Limper, A. H. & La Russo, N. F., Dec 1 2005, In : Journal of Immunology. 175, 11, p. 7447-7456 10 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Defensins
Infection
Parasites
Proteins
14 Citations (Scopus)

Perceived impact of duty hours limits on the fragmentation of patient care: Results from an academic health center

Keating, R. J., La Russo, N. F. & Kolars, J. C., Jul 2005, In : American Journal of Medicine. 118, 7, p. 788-793 6 p.

Research output: Contribution to journalArticle

Personnel Staffing and Scheduling
Physicians' Practice Patterns
Physician-Patient Relations
Job Satisfaction
Quality of Health Care
18 Citations (Scopus)

Regulated vesicle trafficking of membrane transporters in hepatic epithelia

Marinelli, R. A., Tietz, P. S. & La Russo, N. F., Apr 2005, In : Journal of Hepatology. 42, 4, p. 592-603 12 p.

Research output: Contribution to journalArticle

Membrane Transport Proteins
Epithelium
Liver
215 Citations (Scopus)

The value of serum CA 19-9 in predicting cholangiocarcinomas in patients with primary sclerosing cholangitis

Levy, C., Lymp, J., Angulo, P., Gores, G. J., La Russo, N. F. & Lindor, K. D., Sep 2005, In : Digestive Diseases and Sciences. 50, 9, p. 1734-1740 7 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Cholangiocarcinoma
Serum
Sensitivity and Specificity
2004
54 Citations (Scopus)

Apical organelle discharge by Cryptosporidium parvum is temperature, cytoskeleton, and intracellular calcium dependent and required for host cell invasion

Chen, X. M., O'Hara, S. P., Huang, B. Q., Nelson, J. B., Lin, J. J. C., Zhu, G., Ward, H. D. & La Russo, N. F., Dec 2004, In : Infection and Immunity. 72, 12, p. 6806-6816 11 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Cytoskeleton
Organelles
Parasites
Calcium
21 Citations (Scopus)

AQP4 Transfected into Mouse Cholangiocytes Promotes Water Transport in Biliary Epithelia

Splinter, P. L., Masyuk, A. I., Marinelli, R. A. & La Russo, N. F., Jan 2004, In : Hepatology. 39, 1, p. 109-116 8 p.

Research output: Contribution to journalArticle

Epithelium
Aquaporins
Water
Transcytosis
Mammals
75 Citations (Scopus)

Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease

Masyuk, T. V., Huang, B. Q., Masyuk, A. I., Ritman, E. L., Torres, V., Wang, X., Harris, P. C. & La Russo, N. F., Nov 2004, In : American Journal of Pathology. 165, 5, p. 1719-1730 12 p.

Research output: Contribution to journalArticle

Autosomal Recessive Polycystic Kidney
Cilia
Liver
Bile Ducts
Cysts
38 Citations (Scopus)

Cdc42 and the Actin-Related Protein/Neural Wiskott-Aldrich Syndrome Protein Network Mediate Cellular Invasion by Cryptosporidium parvum

Chen, X. M., Huang, B. Q., Splinter, P. L., Orth, J. D., Billadeau, D. D., Mc Niven, M. A. & La Russo, N. F., May 2004, In : Infection and Immunity. 72, 5, p. 3011-3021 11 p.

Research output: Contribution to journalArticle

Wiskott-Aldrich Syndrome Protein
Cryptosporidium parvum
Actins
Proteins
Parasites
3 Citations (Scopus)

Cholangiocyte biology

Tietz, P. S. & La Russo, N. F., May 2004, In : Current Opinion in Gastroenterology. 20, 3, p. 270-274 5 p.

Research output: Contribution to journalArticle

Cholestasis
Bile
Theoretical Models
Technology
Animal Disease Models
36 Citations (Scopus)

Clinicopathological correlates of aspartyl (asparaginyl) β-hydroxylase over-expression in cholangiocarcinoma

Maeda, T., Taguchi, K. I., Aishima, S. I., Shimada, M., Hintz, D., La Russo, N. F., Gores, G. J., Tsuneyoshi, M., Sugimachi, K., Wands, J. R. & Monte, S. M. D. L., 2004, In : Cancer Detection and Prevention. 28, 5, p. 313-318 6 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Mixed Function Oxygenases
Sclerosing Cholangitis
Neoplasms
Growth
59 Citations (Scopus)

Cryptosporidium parvum attachment to and internalization by human biliary epithelia in vitro: A morphologic study

Huang, B. Q., Chen, X. M. & La Russo, N. F., Apr 2004, In : Journal of Parasitology. 90, 2, p. 212-221 10 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
parasite
Parasites
epithelium
Epithelium
10 Citations (Scopus)

Differential expression of cholangiocyte and ileal bile acid transporters following bile acid supplementation and depletion

Kip, N. S., Lazaridis, K. N., Masyuk, A. I., Splinter, P. L., Huebert, R. C. & La Russo, N. F., May 15 2004, In : World Journal of Gastroenterology. 10, 10, p. 1440-1446 7 p.

Research output: Contribution to journalArticle

Taurocholic Acid
Bile Acids and Salts
Cholestyramine Resin
Diet
Intrahepatic Bile Ducts
38 Citations (Scopus)

Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42

Chen, X. M., Splinter, P. L., Tietz, P. S., Huang, B. Q., Billadeau, D. D. & La Russo, N. F., Jul 23 2004, In : Journal of Biological Chemistry. 279, 30, p. 31671-31678 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Cryptosporidium parvum
Chemical activation
Parasites
Actins
258 Citations (Scopus)

The cholangiopathies: Disorders of biliary epithelia

Lazaridis, K. N., Strazzabosco, M. & La Russo, N. F., Nov 2004, In : Gastroenterology. 127, 5, p. 1565-1577 13 p.

Research output: Contribution to journalArticle

Bile Duct Diseases
Intrahepatic Bile Ducts
Biological Models
Epithelium
Epithelial Cells
2003
97 Citations (Scopus)

Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes

Tietz, P. S., Marinelli, R. A., Chen, X. M., Huang, B., Cohn, J., Kole, J., Mc Niven, M. A., Alper, S. & La Russo, N. F., May 30 2003, In : Journal of Biological Chemistry. 278, 22, p. 20413-20419 7 p.

Research output: Contribution to journalArticle

Aquaporin 1
Carrier Proteins
Ions
Cystic Fibrosis
Water