• 27732 Citations
  • 95 Scopus h-Index
1973 …2020

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Long-term results of patients undergoing liver transplantation for primary sclerosing cholangitis

Graziadei, I. W., Wiesner, R. H., Marotta, P. J., Porayko, M. K., Eileen Hay, J., Charlton, M. R., Poterucha, J. J., Rosen, C. B., Gores, G. J., LaRusso, N. E. & Krom, R. A. F., Nov 11 1999, In : Hepatology. 30, 5, p. 1121-1127 7 p.

Research output: Contribution to journalArticle

269 Scopus citations

Lymphocyte subsets in primary sclerosing cholangitis

Lindor, K. D., Wiesner, R. H., Katzmann, J. A., Larusso, N. F. & Beaver, S. J., Jul 1 1987, In : Digestive diseases and sciences. 32, 7, p. 720-725 6 p.

Research output: Contribution to journalArticle

54 Scopus citations

Macrophages contribute to the pathogenesis of sclerosing cholangitis in mice

Guicciardi, M. E., Trussoni, C. E., Krishnan, A., Bronk, S. F., Lorenzo Pisarello, M. J., O'Hara, S. P., Splinter, P. L., Gao, Y., Vig, P., Revzin, A., La Russo, N. F. & Gores, G. J., Jan 1 2018, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

21 Scopus citations

Magnetic resonance cholangiography in patients with biliary disease: Its role in primary sclerosing cholangitis

Angulo, P., Pearce, D. H., Johnson, C. D., Henry, J. J., LaRusso, N. F., Petersen, B. T. & Lindor, K. D., Jan 1 2000, In : Journal of hepatology. 33, 4, p. 520-527 8 p.

Research output: Contribution to journalArticle

133 Scopus citations

Manifestations of nonsuppurative cholangitis in chronic hepatobiliary diseases: morphologic spectrum, clinical correlations and terminology

Ludwig, J., Czaja, A. J., Dickson, E. R., LaRusso, N. F. & Wiesner, R. H., Apr 1984, In : Liver. 4, 2, p. 105-116 12 p.

Research output: Contribution to journalArticle

103 Scopus citations

Membrane microdomains in hepatocytes: Potential target areas for proteins involved in canalicular bile secretion

Tietz, P., Jefferson, J., Pagano, R. & LaRusso, N. F., Dec 1 2005, In : Journal of Lipid Research. 46, 7, p. 1426-1432 7 p.

Research output: Contribution to journalArticle

47 Scopus citations

Metabolomic profiling of portal blood and bile reveals metabolic signatures of primary sclerosing cholangitis

Tietz-Bogert, P. S., Kim, M., Cheung, A., Tabibian, J. H., Heimbach, J., Rosen, C., Nandakumar, M., Lazaridis, K. N., Larusso, N. F., Sung, J. & O’hara, S. P., Oct 16 2018, In : International Journal of Molecular Sciences. 19, 10, 3188.

Research output: Contribution to journalArticle

5 Scopus citations

Microbiome-immune interactions and liver disease

Tabibian, J. H., Varghese, C., O'Hara, S. P. & La Russo, N. F., Apr 1 2015, In : Clinical Liver Disease. 5, 4, p. 83-85 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Micro-computed tomography and nuclear magnetic resonance imaging for noninvasive, live-mouse cholangiography

Tabibian, J. H., MacUra, S. I., O'Hara, S. P., Fidler, J. L., Glockner, J. F., Takahashi, N., Lowe, V. J., Kemp, B. J., Mishra, P. K., Tietz, P. S., Splinter, P. L., Trussoni, C. E. & Larusso, N. F., Jun 1 2013, In : Laboratory Investigation. 93, 6, p. 733-743 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma

Mansini, A. P., Lorenzo Pisarello, M. J., Thelen, K. M., Cruz-Reyes, M., Peixoto, E., Jin, S., Howard, B. N., Trussoni, C. E., Gajdos, G. B., LaRusso, N. F., Perugorria, M. J., Banales, J. M. & Gradilone, S. A., Aug 2018, In : Hepatology. 68, 2, p. 561-573 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease

Lee, S. O., Masyuk, T., Splinter, P., Banales, J. M., Masyuk, A., Stroope, A. & LaRusso, N., Nov 3 2008, In : Journal of Clinical Investigation. 118, 11, p. 3714-3724 11 p.

Research output: Contribution to journalArticle

126 Scopus citations

MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3

Selaru, F. M., Olaru, A. V., Kan, T., David, S., Cheng, Y., Mori, Y., Yang, J., Paun, B., Jin, Z., Agarwal, R., Hamilton, J. P., Abraham, J., Georgiades, C., Alvarez, H., Vivekanandan, P., Yu, W., Maitra, A., Torbenson, M., Thuluvath, P. J., Gores, G. J. & 3 others, LaRusso, N. F., Hruban, R. & Meltzer, S. J., May 1 2009, In : Hepatology. 49, 5, p. 1595-1601 7 p.

Research output: Contribution to journalArticle

209 Scopus citations

MicroRNA-506 promotes primary biliary cholangitis–like features in cholangiocytes and immune activation

Erice, O., Munoz-Garrido, P., Vaquero, J., Perugorria, M. J., Fernandez-Barrena, M. G., Saez, E., Santos-Laso, A., Arbelaiz, A., Jimenez-Agüero, R., Fernandez-Irigoyen, J., Santamaria, E., Torrano, V., Carracedo, A., Ananthanarayanan, M., Marzioni, M., Prieto, J., Beuers, U., Oude Elferink, R. P., LaRusso, N. F., Bujanda, L. & 2 others, Marin, J. J. G. & Banales, J. M., Apr 2018, In : Hepatology. 67, 4, p. 1420-1440 21 p.

Research output: Contribution to journalArticle

22 Scopus citations

MicroRNA-513 regulates B7-H1 translation and is involved in IFN-γ-induced B7-H1 expression in cholangiocytes

Gong, A. Y., Zhou, R., Hu, G., Li, X., Splinter, P. L., O'Hara, S. P., LaRusso, N. F., Soukup, G. A., Dong, H. & Chen, X. M., Feb 1 2009, In : Journal of Immunology. 182, 3, p. 1325-1333 9 p.

Research output: Contribution to journalArticle

134 Scopus citations

MicroRNAs: Key Modulators of Posttranscriptional Gene Expression

O'Hara, S. P., Mott, J. L., Splinter, P. L., Gores, G. J. & LaRusso, N. F., Jan 2009, In : Gastroenterology. 136, 1, p. 17-25 9 p.

Research output: Contribution to journalArticle

73 Scopus citations

MicroRNAs and benign biliary tract diseases

Gradilone, S. A., O'Hara, S. P., Masyuk, T. V., Pisarello, M. J. L. & Larusso, N. F., Feb 1 2015, In : Seminars in liver disease. 35, 1, p. 26-35 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Microtubule modulation of biliary excretion of endogenous and exogenous hepatic lysosomal constituents.

Sewell, R. B., Barham, S. S., Zinsmeister, A. R. & LaRusso, N. F., Jan 1 1984, In : The American journal of physiology. 246, 1 Pt 1, p. G8-15

Research output: Contribution to journalArticle

21 Scopus citations

Milder disease stage in patients with primary biliary cholangitis over a 44-year period: A changing natural history

on behalf of the GLOBAL PBC Study Group, May 1 2018, In : Hepatology. 67, 5, p. 1920-1930 11 p.

Research output: Contribution to journalArticle

12 Scopus citations

Modified culture conditions enhance expression of differentiated phenotypic properties of normal rat cholangiocytes

Salter, K. D., Roman, R. M., Larusso, N. R., Fitz, J. G. & Doctor, R. B., Jan 1 2000, In : Laboratory Investigation. 80, 11, p. 1775-1778 4 p.

Research output: Contribution to journalArticle

Open Access
27 Scopus citations

Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation

Alpini, G., Ulrich, C., Roberts, S., Phillips, J. O., Ueno, Y., Podila, P. V., Colegio, O., LeSage, G. D., Miller, L. J. & LaRusso, N. F., Feb 1997, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 272, 2 35-2, p. G289-G297

Research output: Contribution to journalArticle

116 Scopus citations

Molecular studies of ceruloplasmin deficiency in Wilson's disease

Czaja, M. J., Weiner, F. R., Schwarzenberg, S. J., Sternlieb, I., Scheinberg, I. H., Van Thiel, D. H., LaRusso, N. F., Giambrone, M. A., Kirschner, R., Koschinsky, M. L., MacGillivray, R. T. A. & Zern, M. A., Jan 1 1987, In : Journal of Clinical Investigation. 80, 4, p. 1200-1204 5 p.

Research output: Contribution to journalArticle

Open Access
43 Scopus citations

Monooctanoin, a dissolution agent for retained cholesterol bile duct stones: Physical properties and clinical application

Thistle, J. L., Carlson, G. L., Hofmann, A. F., LaRusso, N. F., MacCarty, R. L., Flynn, G. L., Higuchi, W. I. & Babayan, V. K., May 1980, In : Gastroenterology. 78, 5 PART 1, p. 1016-1022 7 p.

Research output: Contribution to journalArticle

Open Access
100 Scopus citations

Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver

Alpini, G., Roberts, S., Kuntz, S. M., Ueno, Y., Gubba, S., Podila, P. V., LeSage, G. & LaRusso, N. F., Jan 1 1996, In : Gastroenterology. 110, 5, p. 1636-1643 8 p.

Research output: Contribution to journalArticle

183 Scopus citations

Morphologic demonstration of receptor-mediated endocytosis of epidermal growth factor by isolated bile duct epithelial cells

Ishii, M., Vroman, B. & LaRusso, N. F., May 1990, In : Gastroenterology. 98, 5 PART 1, p. 1284-1291 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Morphologic features of chronic hepatitis associated with primary sclerosing cholangitis and chronic ulcerative colitis

Ludwig, J., Barham, S. S., Larusso, N. F., Elveback, L. R., Wiesner, R. H. & McCall, J. T., Jan 1 1981, In : Hepatology. 1, 6, p. 632-640 9 p.

Research output: Contribution to journalArticle

277 Scopus citations

Morphology, physiology, and biochemistry of biliary epithelia

Larusso, N. F., Jan 1 1996, In : Toxicologic Pathology. 24, 1, p. 84-89 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Multiple TLRs are expressed in human cholangiocytes and mediate host epithelial defense responses to Cryptosporidium parvum via activation of NF-κB

Chen, X. M., O'Hara, S. P., Nelson, J. B., Splinter, P. L., Small, A. J., Tietz, P. S., Limper, A. H. & LaRusso, N. F., Dec 1 2005, In : Journal of Immunology. 175, 11, p. 7447-7456 10 p.

Research output: Contribution to journalArticle

149 Scopus citations

Neutrophil cytoplasmic antibodies: A link between primary sclerosing cholangitis and ulcerative colitis

Duerr, R. H., Targan, S. R., Landers, C. J., Larusso, N. F., Lindsay, K. L., Wiesner, R. H. & Shanahan, F., May 1991, In : Gastroenterology. 100, 5 PART 1, p. 1385-1391 7 p.

Research output: Contribution to journalArticle

280 Scopus citations

NFκB p50-CCAAT/enhancer-binding protein β (C/EBPβ)-mediated transcriptional repression of microRNA let-7i following microbial infection

O'Hara, S. P., Splinter, P. L., Gajdos, G. B., Trussoni, C. E., Fernandez-Zapico, M. E., Chen, X. M. & LaRusso, N. F., Jan 1 2010, In : Journal of Biological Chemistry. 285, 1, p. 216-225 10 p.

Research output: Contribution to journalArticle

81 Scopus citations

Nitric oxide-mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes

Jaiswal, M., LaRusso, N. F., Shapiro, R. A., Billiar, T. R. & Gores, G. J., Jan 1 2001, In : Gastroenterology. 120, 1, p. 190-199 10 p.

Research output: Contribution to journalArticle

154 Scopus citations

Nonoperative dilatation of dominant strictures in primary sclerosing cholangitis

May, G. R., Bender, C. E., LaRusso, N. F. & Wiesner, R. H., Jan 1 1985, In : American Journal of Roentgenology. 145, 5, p. 1061-1064 4 p.

Research output: Contribution to journalArticle

81 Scopus citations
199 Scopus citations

Opisthorchis viverrini excretory/secretory products induce toll-like receptor 4 upregulation and production of interleukin 6 and 8 in cholangiocyte

Ninlawan, K., O'Hara, S. P., Splinter, P. L., Yongvanit, P., Kaewkes, S., Surapaitoon, A., LaRusso, N. F. & Sripa, B., Dec 1 2010, In : Parasitology International. 59, 4, p. 616-621 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Optimization of a research web environment for academic internal medicine faculty

Elkin, P. L., Sorensen, B., De Palo, D., Poland, G., Bailey, K. R., Wood, D. L. & Larusso, N. F., Sep 1 2002, In : Journal of the American Medical Informatics Association. 9, 5, p. 472-478 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Oral budesonide in the treatment of primary sclerosing cholangitis

Angulo, P., Batts, K. P., Jorgensen, R. A., LaRusso, N. A. & Lindor, K. D., Oct 2 2000, In : American Journal of Gastroenterology. 95, 9, p. 2333-2337 5 p.

Research output: Contribution to journalArticle

115 Scopus citations

Oral nicotine in treatment of primary sclerosing cholangitis. A pilot study

Angulo, P., Bharucha, A. E., Jorgensen, R. A., DeSotel, C. K., Sandborn, W. J., Larusso, N. F. & Lindor, K. D., Jan 1 1999, In : Digestive diseases and sciences. 44, 3, p. 602-607 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Pasireotide is more effective than octreotide in reducing hepatorenal cystogenesis in rodents with polycystic kidney and liver diseases

Masyuk, T. V., Radtke, B. N., Stroope, A. J., Banales, J. M., Gradilone, S. A., Huang, B., Masyuk, A. I., Hogan, M. C., Torres, V. E. & Larusso, N. F., Jul 1 2013, In : Hepatology. 58, 1, p. 409-421 13 p.

Research output: Contribution to journalArticle

63 Scopus citations

Passing the torch: A look back at our editorship

LaRusso, N. F., Phillips, S. F., Bloomer, J. R., Boland, C. R., Chang, E. B., DiMagno, E. P., Giannella, R. A., Gores, G. J., Malagelada, J. R., Miller, L. J., Rakela, J., Szurszewski, J. H., Binder, H. J., Clain, J. E., LaMont, J. T. & Link, A. M., Jan 1 1996, In : Gastroenterology. 110, 5, p. 1336-1338 3 p.

Research output: Contribution to journalArticle

Pathobiology of biliary epithelia

Cheung, A. C., Lorenzo Pisarello, M. J. & La Russo, N. F., 2017, (Accepted/In press) In : Biochimica et Biophysica Acta - Molecular Basis of Disease.

Research output: Contribution to journalArticle

11 Scopus citations

Pathobiology of biliary epithelia and cholangiocarcinoma: Proceedings of the Henry M. and Lillian Stratton Basic Research Single-Topic Conference

Sirica, A. E., Nathanson, M. H., Gores, G. J. & LaRusso, N. F., Dec 1 2008, In : Hepatology. 48, 6, p. 2040-2046 7 p.

Research output: Contribution to journalArticle

26 Scopus citations

Patients, cells, and organelles: The intersection of science and serendipity

Larusso, N. F., May 1 2011, In : Hepatology. 53, 5, p. 1417-1426 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Patients with asymptomatic primary sclerosing cholangitis frequently have progressive disease

Porayko, M. K., Wiesner, R. H., LaRusso, N. F., Ludwig, J., MacCarty, R. L., Steiner, B. L., Twomey, C. K. & Zinsmeister, A. R., Jun 1990, In : Gastroenterology. 98, 6, p. 1594-1602 9 p.

Research output: Contribution to journalArticle

114 Scopus citations

Performance of magnetic resonance elastography in primary sclerosing cholangitis

Eaton, J. E., Dzyubak, B., Venkatesh, S. K., Smyrk, T. C., Gores, G. J., Ehman, R. L., La Russo, N. F., Gossard, A. A. & Lazaridis, K. N., Jun 1 2016, In : Journal of Gastroenterology and Hepatology (Australia). 31, 6, p. 1184-1190 7 p.

Research output: Contribution to journalArticle

39 Scopus citations

Perfused rat intrahepatic bile ducts secrete and absorb water, solute, and ions

Masyuk, A. I., Gong, A. Y., Kip, S., Burke, M. J. & LaRusso, N. F., Jan 1 2000, In : Gastroenterology. 119, 6, p. 1672-1680 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Peristomal varices after proctocolectomy in patients with primary sclerosing cholangitis

Wiesner, R. H., LaRusso, N. F., Dozois, R. R. & Beaver, S. J., Feb 1986, In : Gastroenterology. 90, 2, p. 316-322 7 p.

Research output: Contribution to journalArticle

99 Scopus citations

Pharmacologic perturbation of rat liver lysosomes: Effects on release of lysosomal enzymes and of lipids into bile

Sewell, R. B., Grinpukel, S. A., Zinsmeister, A. R. & LaRusso, N. F., Oct 1988, In : Gastroenterology. 95, 4, p. 1088-1098 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Phosphatidylinositol 3-kinase and frabin mediate Cryptosporidium parvum cellular invasion via activation of Cdc42

Chen, X. M., Splinter, P. L., Tietz, P. S., Huang, B. Q., Billadeau, D. D. & LaRusso, N. F., Jul 23 2004, In : Journal of Biological Chemistry. 279, 30, p. 31671-31678 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Physicochemical determinants in hepatic extraction of small peptides

Hunter, E. B., Powers, S. P., Kost, L. J., Pinon, D. I., Miller, L. J. & LaRusso, N. F., Jul 1990, In : Hepatology. 12, 1, p. 76-82 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Physiology of cholangiocytes

Tabibian, J. H., Masyuk, A. I., Masyuk, T. V., O'Hara, S. P. & LaRusso, N. F., Jul 2 2013, In : Comprehensive Physiology. 3, 1, p. 541-565 25 p.

Research output: Contribution to journalArticle

88 Scopus citations

Pirfenidone in the treatment of primary sclerosing cholangitis

Angulo, P., MacCarty, R. L., Sylvestre, P. B., Jorgensen, R. A., Wiesner, R. H., LaRusso, N. A. & Lindor, K. D., Jan 29 2002, In : Digestive diseases and sciences. 47, 1, p. 157-161 5 p.

Research output: Contribution to journalArticle

49 Scopus citations