• 27137 Citations
  • 93 Scopus h-Index
1973 …2020
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Research Output 1973 2020

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130 Citations (Scopus)

Secretin induces the apical insertion of aquaporin-1 water channels in rat cholangiocytes

Marinelli, R. A., Tietz, P. S., Pham, L. D., Rueckert, L., Agre, P. & La Russo, N. F., Jan 1999, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 276, 1 39-1

Research output: Contribution to journalArticle

Aquaporin 1
Aquaporins
Secretin
Bile
Cell Membrane
159 Citations (Scopus)
Aquaporin 1
Aquaporins
Secretin
Cell membranes
Rats
125 Citations (Scopus)
Secretin
Exocytosis
Bile Ducts
Cyclic AMP
Ducts
133 Citations (Scopus)

Selection and timing of liver transplantation in primary biliary cirrhosis and primary sclerosing cholangitis

Wiesner, R. H., Porayko, M. K., Dickson, E. R., Gores, G. J., La Russo, N. F., Hay, J. E., Wahlstrom, H. E. & Krom, R. A. F., 1992, In : Hepatology. 16, 5, p. 1290-1299 10 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Biliary Liver Cirrhosis
Liver Transplantation
Survival
Liver Diseases
60 Citations (Scopus)

Serum lipid and fat-soluble vitamin levels in primary sclerosing cholangitis

Jorgensen, R. A., Lindor, K. D., Sartin, J. S., La Russo, N. F. & Wiesner, R. H., 1995, In : Journal of Clinical Gastroenterology. 20, 3, p. 215-219 5 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Vitamins
Fats
Lipids
Serum
2 Citations (Scopus)

Simple method for simultaneous specific activity measurements in a mixture of radiolabeled bile acids

Belobaba, D. T. E., Carlson, G. L. & La Russo, N. F., Apr 21 1979, In : Journal of Chromatography A. 172, 1, p. 410-416 7 p.

Research output: Contribution to journalArticle

Thin layer chromatography
Bile Acids and Salts
Hot Temperature
34 Citations (Scopus)

Solute and water transport pathways in cholangiocytes

Marinelli, R. A. & La Russo, N. F., 1996, In : Seminars in Liver Disease. 16, 2, p. 221-229 9 p.

Research output: Contribution to journalArticle

Somatostatin Receptors
Aquaporins
Membranes
Membrane Transport Proteins
Water
86 Citations (Scopus)

Somatostatin analog therapy for severe polycystic liver disease: Results after 2 years

Hogan, M. C., Masyuk, T. V., Page, L., Holmes III, D. R., Li, X., Bergstralh, E. J., Irazabal Mira, M., Kim, B., King, B. F., Glockner, J., La Russo, N. F. & Torres, V., Sep 2012, In : Nephrology Dialysis Transplantation. 27, 9, p. 3532-3539 8 p.

Research output: Contribution to journalArticle

Somatostatin
Placebos
Liver
Kidney
Glomerular Filtration Rate
91 Citations (Scopus)
secretin
somatostatin
Secretin
bile ducts
exocytosis

Somatostatin receptor imaging in cholangiocarcinoma [1]

Jamar, F., Pauwels, S., Horsmans, Y., Deprez, P., Tan, C. K., La Russo, N. F. & Gores, G. J., 1996, In : Gastroenterology. 110, 5, p. 1675-1676 2 p.

Research output: Contribution to journalArticle

Bile Duct Neoplasms
Intrahepatic Bile Ducts
Somatostatin Receptors
Cholangiocarcinoma
51 Citations (Scopus)

Somatostatin stimulates ductal bile absorption and inhibits ductal bile secretion in mice via SSTR2 on cholangiocytes

Gong, A. Y., Tietz, P. S., Muff, M. A., Splinter, P. L., Huebert, R. C., Strowski, M. Z., Chen, X. M. & La Russo, N. F., May 1 2003, In : American Journal of Physiology - Cell Physiology. 284, 5 53-5

Research output: Contribution to journalArticle

Somatostatin
Intrahepatic Bile Ducts
Bile
Ducts
Secretin
54 Citations (Scopus)

Specific inhibition of AQP1 water channels in isolated rat intrahepatic bile duct units by small interfering RNAs

Splinter, P. L., Masyuk, A. I. & La Russo, N. F., Feb 21 2003, In : Journal of Biological Chemistry. 278, 8, p. 6268-6274 7 p.

Research output: Contribution to journalArticle

Intrahepatic Bile Ducts
Aquaporins
Ducts
Small Interfering RNA
Rats
17 Citations (Scopus)

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging

Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., Frantz, M. C., Bell-Temin, H., Pope-Varsalona, H., Gurkar, A. U., Nasto, L. A., Robinson, R. A. S., Fuhrmann-Stroissnigg, H., Czerwinska, J., McGowan, S. J., Cantu-Medellin, N. & 22 others, Harris, J. B., Maniar, S., Ross, M. A., Trussoni, C. E., La Russo, N. F., Cifuentes-Pagano, E., Pagano, P. J., Tudek, B., Vo, N. V., Rigatti, L. H., Opresko, P. L., Stolz, D. B., Watkins, S. C., Burd, C. E., Croix, C. M. S., Siuzdak, G., Yates, N. A., Robbins, P. D., Wang, Y., Wipf, P., Kelley, E. E. & Niedernhofer, L. J., Jul 1 2018, In : Redox Biology. 17, p. 259-273 15 p.

Research output: Contribution to journalArticle

DNA Damage
Oxidation-Reduction
Genes
Aging of materials
Genome
11 Citations (Scopus)

Standardized care processes to improve quality and safety of patient care in a large academic practice: The Plummer Project of the Department of Medicine, Mayo Clinic

Wood, D. L., Brennan, M. D., Chaudhry, R., Chihak, A. A., Feyereisn, W. L., Woychick, N. L., Hagen, P. T., Curtright, J. W., Naessens, J. M., Spurrier, B. R. & La Russo, N. F., 2008, In : Health Services Management Research. 21, 4, p. 276-280 5 p.

Research output: Contribution to journalArticle

Patient Care
Medicine
Physicians
Safety
Biomedical Enhancement
62 Citations (Scopus)

Stimulation of ATP secretion in the liver by therapeutic bile acids

Nathanson, M. H., Burgstahler, A. D., Masyuk, A. & La Russo, N. F., Aug 15 2001, In : Biochemical Journal. 358, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Bile Acids and Salts
Liver
Adenosine Triphosphate
Bile
Ursodeoxycholic Acid
21 Citations (Scopus)

Strategies for improving attendance at medical grand rounds at an Academic Medical Center

Mueller, P., Litin, S. C., Sowden, M. L., Habermann, T. M. & La Russo, N. F., May 1 2003, In : Mayo Clinic Proceedings. 78, 5, p. 549-553 5 p.

Research output: Contribution to journalArticle

Teaching Rounds
Needs Assessment
Tertiary Healthcare
Research Personnel
17 Citations (Scopus)

Successful implementation of a telemedicine-based counseling program for high-risk patients with breast cancer

Pruthi, S., Stange, K. J., Malagrino, G. D., Chawla, K. S., La Russo, N. F. & Kaur, J. S., 2013, In : Mayo Clinic Proceedings. 88, 1, p. 68-73 6 p.

Research output: Contribution to journalArticle

Telemedicine
Counseling
Breast Neoplasms
Referral and Consultation
Patient Satisfaction
21 Citations (Scopus)

Surreptitious laxative ingestion. Delayed recognition of a serious condition: a case report

La Russo, N. F. & McGill, D. B., 1975, In : Mayo Clinic Proceedings. 50, 12, p. 706-708 3 p.

Research output: Contribution to journalArticle

Laxatives
Eating
Phenolphthalein
Melanosis
Feces
28 Citations (Scopus)

Targeting senescent cholangiocytes and activated fibroblasts with B-cell lymphoma-extra large inhibitors ameliorates fibrosis in multidrug resistance 2 gene knockout (Mdr2−/−) mice

Moncsek, A., Al-Suraih, M. S., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Zuber, C., Patsenker, E., Valli, P. V., Fingas, C. D., Weber, A., Zhu, Y., Tchkonia, T., Kirkland, J. L., Gores, G. J., Müllhaupt, B., La Russo, N. F. & Mertens, J. C., Jan 1 2018, In : Hepatology. 67, 1, p. 247-259 13 p.

Research output: Contribution to journalArticle

MDR Genes
Gene Knockout Techniques
B-Cell Lymphoma
Knockout Mice
Fibrosis
77 Citations (Scopus)

T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis

Allina, J., Hu, B., Sullivan, D. M., Fiel, M. I., Thung, S. N., Bronk, S. F., Huebert, R. C., van de Water, J., La Russo, N. F., Gershwin, M. E., Gores, G. J. & Odin, J. A., Dec 2006, In : Journal of Autoimmunity. 27, 4, p. 232-241 10 p.

Research output: Contribution to journalArticle

Cytophagocytosis
Biliary Liver Cirrhosis
Autoantigens
Epithelial Cells
Phagocytosis

Temporal elements in career selection decisions: An archival study investigating career decisions in medicine

Shah, P. P., Bechara, J. P., Kolars, J., Drefahl, M., La Russo, N. F., Wood, D. & Spurrier, B., Jan 2014, In : Organization Science. 25, 1, p. 245-261 17 p.

Research output: Contribution to journalArticle

Medicine
Decision making
Boundary conditions
Career decision
Schedule

Tempora mutantur, nos et mutamur in illis!

La Russo, N. F. & Link, A. M., 1993, In : Gastroenterology. 104, 1, p. 3-5 3 p.

Research output: Contribution to journalArticle

Gastroenterology
9 Citations (Scopus)

TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling

Masyuk, T. V., Masyuk, A. I., Lorenzo Pisarello, M., Howard, B. N., Huang, B. Q., Lee, P. Y., Fung, X., Sergienko, E., Ardecky, R. J., Chung, T. D. Y., Pinkerton, A. B. & La Russo, N. F., 2017, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

GTP-Binding Proteins
Cyclic AMP
Rodentia
Liver
Oleanolic Acid
15 Citations (Scopus)

TGR5 in the cholangiociliopathies

Masyuk, T. V., Masyuk, A. I. & La Russo, N. F., Jun 9 2015, In : Digestive Diseases. 33, 3, p. 420-425 6 p.

Research output: Contribution to journalArticle

Cilia
Cysts
Sclerosing Cholangitis
Cholangiocarcinoma
Liver
425 Citations (Scopus)

The Achilles' heel of senescent cells: From transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O'Hara, S. P., La Russo, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., LeBrasseur, N. K., Wren, J. D., Farr, J., Khosla, S., Stout, M. B. & 13 others, Mcgowan, S. J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Zhao, J., Colangelo, D., Dorronsoro, A., Ling, Y. Y., Barghouthy, A. S., Navarro, D. C., Sano, T., Robbins, P. D., Niedernhofer, L. J. & Kirkland, J. L., 2015, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

Transcriptome
Pharmaceutical Preparations
Quercetin
Transgenic Suicide Genes
Ephrins

The AGA Institute: A Professional Society With a Social Conscience

La Russo, N. F., Dec 2008, In : Gastroenterology. 135, 6

Research output: Contribution to journalArticle

4 Citations (Scopus)

The "age" factor in adult medicine

Tefferi, A. & La Russo, N. F., Jul 1 2003, In : Mayo Clinic Proceedings. 78, 7, p. 913 1 p.

Research output: Contribution to journalArticle

Age Factors
Medicine

The American Liver Foundation celebrates 10 years of achievement by establishing the Liver Scholar Award.

Hofmann, A. F. & La Russo, N. F., Nov 1986, In : Hepatology. 6, 6, p. 1422 1 p.

Research output: Contribution to journalArticle

Liver Diseases
Liver
5 Citations (Scopus)

The application of design principles to innovate clinical care delivery.

Brennan, M. D., Duncan, A. K., Armbruster, R. R., Montori, V. M., Feyereisn, W. L. & La Russo, N. F., Jan 2009, In : Journal for healthcare quality : official publication of the National Association for Healthcare Quality. 31, 1, p. 5-9 5 p.

Research output: Contribution to journalArticle

National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
Delivery of Health Care
Research
Manufacturing Industry
Clinical Studies
82 Citations (Scopus)

The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD)

Banales, J. M., Masyuk, T. V., Gradilone, S. A., Masyuk, A. I., Medina, J. F. & La Russo, N. F., 2009, In : Hepatology. 49, 1, p. 160-174 15 p.

Research output: Contribution to journalArticle

Autosomal Recessive Polycystic Kidney
Cyclic AMP
Protein Kinases
Animal Models
Liver
259 Citations (Scopus)

The cholangiopathies: Disorders of biliary epithelia

Lazaridis, K. N., Strazzabosco, M. & La Russo, N. F., Nov 2004, In : Gastroenterology. 127, 5, p. 1565-1577 13 p.

Research output: Contribution to journalArticle

Bile Duct Diseases
Intrahepatic Bile Ducts
Biological Models
Epithelium
Epithelial Cells
92 Citations (Scopus)

The cholangiopathies

Lazaridis, K. N. & La Russo, N. F., Jun 1 2015, In : Mayo Clinic Proceedings. 90, 6, p. 791-800 10 p.

Research output: Contribution to journalArticle

Liver
Transplants
Biliary Atresia
Sclerosing Cholangitis
End Stage Liver Disease
118 Citations (Scopus)

The combination of prednisone and colchicine in patients with primary sclerosing cholangitis

Lindor, K. D., Wiesner, R. H., Colwell, L. J., Steiner, B., Beaver, S. & La Russo, N. F., 1991, In : American Journal of Gastroenterology. 86, 1, p. 57-61 5 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Colchicine
Prednisone
Ascites
Liver
79 Citations (Scopus)

The dynamic biliary epithelia: Molecules, pathways, and disease

O'Hara, S. P., Tabibian, J. H., Splinter, P. L. & La Russo, N. F., Mar 2013, In : Journal of Hepatology. 58, 3, p. 575-582 8 p.

Research output: Contribution to journalArticle

Epithelium
Liver
Wounds and Injuries
Population Dynamics
Bile Ducts
18 Citations (Scopus)

The enteric microbiome in hepatobiliary health and disease

Tabibian, J. H., Varghese, C., La Russo, N. F. & O'Hara, S. P., 2015, (Accepted/In press) In : Liver International.

Research output: Contribution to journalArticle

Microbiota
Health
Disease Progression
Liver
Gastrointestinal Microbiome
9 Citations (Scopus)
Sclerosing Cholangitis
Pathology
Cholagogues and Choleretics
Cholestasis
Immunosuppressive Agents
15 Citations (Scopus)

The human immunodeficiency virus type 1 Tat protein enhances Cryptosporidium parvum-induced apoptosis in cholangiocytes via a Fas ligand-dependent mechanism

O'Hara, S. P., Small, A. J., Nelson, J. B., Badley, A. D., Chen, X. M., Gores, G. J. & La Russo, N. F., Feb 2007, In : Infection and Immunity. 75, 2, p. 684-696 13 p.

Research output: Contribution to journalArticle

Cryptosporidium parvum
Fas Ligand Protein
Trans-Activators
HIV-1
Apoptosis
50 Citations (Scopus)

The immunobiology of cholangiocytes

Chen, X. M., O'Hara, S. P. & La Russo, N. F., Aug 2008, In : Immunology and Cell Biology. 86, 6, p. 497-505 9 p.

Research output: Contribution to journalArticle

Liver
Biliary Tract
Immunity
Mucosal Immunity
Kupffer Cells
8 Citations (Scopus)

The ins and outs of membrane movement in biliary epithelia.

La Russo, N. F., Ishii, M. & Vroman, B. T., 1990, In : Transactions of the American Clinical and Climatological Association. 102, p. 245-258 14 p.

Research output: Contribution to journalArticle

Intrahepatic Bile Ducts
Epithelium
Epithelial Cells
Membranes
Endocytosis
248 Citations (Scopus)

The isolated perfused rat liver: Conceptual and practical considerations

Gores, G. J., Kost, L. J. & La Russo, N. F., 1986, In : Hepatology. 6, 3, p. 511-517 7 p.

Research output: Contribution to journalArticle

Liver
Bile
Organelles
Hepatocytes
Tissue Survival
22 Citations (Scopus)

The liver and intracellular digestion: How liver cells eat!

Yamazaki, K. & La Russo, N. F., 1989, In : Hepatology. 10, 5, p. 877-886 10 p.

Research output: Contribution to journalArticle

Cell Degranulation
Endocytosis
Lysosomes
Digestion
Homeostasis
99 Citations (Scopus)

The metabolic bone disease of primary sclerosing cholangitis

Hay, J. E., Lindor, K. D., Wiesner, R. H., Dickson, E. R., Krom, R. A. F. & La Russo, N. F., Aug 1991, In : Hepatology. 14, 2, p. 257-261 5 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Metabolic Bone Diseases
Bone Density
Bone Diseases
Serum
107 Citations (Scopus)

The pathobiology of biliary epithelia

Roberts, S. K., Ludwig, J. & La Russo, N. F., 1997, In : Gastroenterology. 112, 1, p. 269-279 11 p.

Research output: Contribution to journalArticle

Theoretical Models
Epithelium
Cell Physiological Phenomena
Allergy and Immunology
Bile
113 Citations (Scopus)

The pathobiology of biliary epithelia

Alpini, G., McGill, J. M. & La Russo, N. F., 2002, In : Hepatology. 35, 5, p. 1256-1268 13 p.

Research output: Contribution to journalArticle

Epithelium
Biliary Liver Cirrhosis
Bile Ducts
Bile
Inflammation Mediators
104 Citations (Scopus)

The relative role of the Child-Pugh classification and the Mayo natural history model in the assessment of survival in patients with primary sclerosing cholangitis

Kim, W. R., Poterucha, J. J., Wiesner, R. H., La Russo, N. F., Lindor, K. D., Petz, J., Therneau, T. M., Malinchoc, M. & Dickson, E. R., 1999, In : Hepatology. 29, 6, p. 1643-1648 6 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Natural History
Survival
Confidence Intervals
Liver Cirrhosis
19 Citations (Scopus)

The role of cilia in the regulation of bile flow

La Russo, N. F. & Masyuk, T. V., Jun 2011, In : Digestive Diseases. 29, 1, p. 6-12 7 p.

Research output: Contribution to journalArticle

Cilia
Bile
Autosomal Recessive Polycystic Kidney
Axoneme
Autosomal Dominant Polycystic Kidney
61 Citations (Scopus)

The syndrome of primary sclerosing cholangitis.

Ludwig, J., La Russo, N. F. & Wiesner, R. H., 1990, In : Progress in Liver Diseases. 9, p. 555-566 12 p.

Research output: Contribution to journalArticle

Intrahepatic Bile Ducts
Sclerosing Cholangitis
Bile Ducts
Terminology
Liver Transplantation

The transcription factor ETS1 promotes apoptosis resistance of senescent cholangiocytes by epigenetically up-regulating the apoptosis suppressor BCL2L1

O'Hara, S. P., Splinter, P. L., Trussoni, C. E., Guicciardi, M. E., Splinter, N. P., Al Suraih, M. S., Nasser-Ghodsi, N., Stollenwerk, D., Gores, G. J. & LaRusso, N. F., Jan 1 2019, In : Journal of Biological Chemistry. 294, 49, p. 18698-18713 16 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Transcription Factors
Apoptosis
Clustered Regularly Interspaced Short Palindromic Repeats
Acetylation
288 Citations (Scopus)
Sclerosing Cholangitis
Cholangiocarcinoma
Serum
Tumor Biomarkers
Bile Ducts
216 Citations (Scopus)

The value of serum CA 19-9 in predicting cholangiocarcinomas in patients with primary sclerosing cholangitis

Levy, C., Lymp, J., Angulo, P., Gores, G. J., La Russo, N. F. & Lindor, K. D., Sep 2005, In : Digestive Diseases and Sciences. 50, 9, p. 1734-1740 7 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Cholangiocarcinoma
Serum
Sensitivity and Specificity