• 27850 Citations
  • 95 Scopus h-Index
1973 …2020

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119 Scopus citations

GUDC inhibits cytochrome c release from human cholangiocyte mitochondria

Que, F. G., Phan, V. A., Phan, V. H., Larusso, N. F. & Gores, G. J., May 15 1999, In : Journal of Surgical Research. 83, 2, p. 100-105 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Hail to the chief-Keith Lindor, our new AASLD president

Shah, V., Gores, G. J. & La Russo, N. F., Feb 1 2016, In : Hepatology. 63, 2, p. 357-359 3 p.

Research output: Contribution to journalArticle

HDAC6 inhibition restores ciliary expression and decreases tumor growth

Gradilone, S. A., Radtke, B. N., Bogert, P. S., Huang, B. Q., Gajdos, G. B. & LaRusso, N. F., Apr 1 2013, In : Cancer research. 73, 7, p. 2259-2270 12 p.

Research output: Contribution to journalArticle

87 Scopus citations

HDAC6 is overexpressed in cystic cholangiocytes and its inhibition reduces cystogenesis

Gradilone, S. A., Habringer, S., Masyuk, T. V., Howard, B. N., Masyuk, A. I. & Larusso, N. F., Mar 1 2014, In : American Journal of Pathology. 184, 3, p. 600-608 9 p.

Research output: Contribution to journalArticle

23 Scopus citations

Health reform: A community experience using design research as a guide

Severson, M. A., Wood, D. L., Chastain, C. N., Lee, L. G., Rees, A. C., Agerter, D. C., Holtz, C. P., Broers, J. K., Savoleinen, K. H., Spurrier, B. R. & Larusso, N. F., Oct 2011, In : Mayo Clinic proceedings. 86, 10, p. 973-980 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Hepatic artery and portal vein remodeling in rat liver: Vascular response to selective cholangiocyte proliferation

Masyuk, T. V., Ritman, E. L. & LaRusso, N. F., Apr 1 2003, In : American Journal of Pathology. 162, 4, p. 1175-1182 8 p.

Research output: Contribution to journalArticle

42 Scopus citations

Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease

Banales, J. M., Masyuk, T. V., Bogert, P. S., Huang, B. Q., Gradilone, S. A., Lee, S. O., Stroope, A. J., Masyuk, A. I., Medina, J. F. & LaRusso, N. F., Dec 2008, In : American Journal of Pathology. 173, 6, p. 1637-1646 10 p.

Research output: Contribution to journalArticle

52 Scopus citations

Hepatic Drug Metabolism and Malignancy

Larusso, N. F., Oct 4 1976, In : JAMA: The Journal of the American Medical Association. 236, 14, p. 1612-1613 2 p.

Research output: Contribution to journalArticle

Hepatic extraction of renin: Quantitation and characterization in the isolated perfused rat liver

Keiser, J. A., Romero, J. C., Kost, L. J. & Larusso, N. F., 1987, In : Hepatology. 7, 6, p. 1254-1261 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Hepatic metabolism and biliary excretion of metronidazole

LaRusso, N. F., Lindmark, D. G. & Muller, M., Jan 1 1976, In : Gastroenterology. 70, 5 (II), 1 p.

Research output: Contribution to journalArticle

3 Scopus citations
61 Scopus citations

Hepatic processing of recombinant human renin: Mechanisms of uptake and degradation

Marks, D. L., Kost, L. J., Kuntz, S. M., Romero, J. C. & LaRusso, N. F., 1991, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 261, 2 24-2, p. G349-G358

Research output: Contribution to journalArticle

14 Scopus citations

Hepatic processing of transforming growth factor β in the rat: Uptake, metabolism, and biliary excretion

Coffey, R. J., Kost, L. J., Lyons, R. M., Moses, H. L. & LaRusso, N. F., 1987, In : Journal of Clinical Investigation. 80, 3, p. 750-757 8 p.

Research output: Contribution to journalArticle

Open Access
125 Scopus citations

Hepatobiliary carcinoma associated with primary sclerosing cholangitis and chronic ulcerative colitis

Wee, A., Ludwig, J., Coffey, R. J., LaRusso, N. F. & Wiesner, R. H., Jul 1985, In : Human Pathology. 16, 7, p. 719-726 8 p.

Research output: Contribution to journalArticle

144 Scopus citations

Hepato-renal pathology in Pkd2ws25/- mice, an animal model of autosomal dominant polycystic kidney disease

Stroope, A., Radtke, B., Huang, B., Masyuk, T., Torres, V., Ritman, E. & LaRusso, N., Mar 2010, In : American Journal of Pathology. 176, 3, p. 1282-1291 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation

Alpini, G., Glaser, S. S., Ueno, Y., Pham, L., Podila, P. V., Caligiuri, A., LeSage, G. & LaRusso, N. F., Apr 1998, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 274, 4 37-4, p. G767-G775

Research output: Contribution to journalArticle

146 Scopus citations

High-dose ursodeoxycholic acid as a therapy for patients with primary sclerosing cholangitis

Harnois, D. M., Angulo, P., Jorgensen, R. A., Larusso, N. F. & Lindor, K. D., May 2001, In : American Journal of Gastroenterology. 96, 5, p. 1558-1562 5 p.

Research output: Contribution to journalArticle

198 Scopus citations

HIV-1 tat protein suppresses cholangiocyte toll- like receptor 4 expression and defense against cryptosporidium parvum

O'Hara, S. P., Small, A. J., Gajdos, G. B., Badley, A. D., Chen, X. M. & LaRusso, N. F., Apr 15 2009, In : Journal of Infectious Diseases. 199, 8, p. 1195-1204 10 p.

Research output: Contribution to journalArticle

20 Scopus citations

Hormones and microtubular binding agents selectively alter biliary lysosomal protein excretion

Sewell, R. B., Kost, L. J., Carter, J. A. & LaRusso, N. F., Jan 1 1981, In : Gastroenterology. 80, 5 II, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Host cell actin remodeling in response to cryptosporidium

O’Hara, S. P., Small, A. J., Chen, X. M. & Larusso, N. F., 2008, In : Sub-Cellular Biochemistry. 47, p. 92-100 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Human cholangiocarcinomas express somatostatin receptors and respond to somatostatin with growth inhibition

Chee Kiat Tan, K. T., Podila, P. V., Taylor, J. E., Nagorney, D. M., Wiseman, G. A., Gores, G. J. & Larusso, N. F., Jun 1995, In : Gastroenterology. 108, 6, p. 1908-1916 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Human Ogg1, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide

Jaiswal, M., LaRusso, N. F., Nishioka, N., Nakabeppu, Y. & Gores, G. J., Aug 1 2001, In : Cancer research. 61, 17, p. 6388-6393 6 p.

Research output: Contribution to journalArticle

157 Scopus citations

Idiopathic adulthood ductopenia. A cause of chronic cholestatic liver disease and biliary cirrhosis

Ludwig, J., Wiesner, R. H. & LaRusso, N. F., 1988, In : Journal of hepatology. 7, 2, p. 193-199 7 p.

Research output: Contribution to journalArticle

134 Scopus citations
25 Scopus citations

II. Effect of chenodeoxycholic acid treatment in gallstone subjects

Northfield, T. C., LaRusso, N. F., Hofmann, A. F. & Thistle, J. L., 1975, In : Gut. 16, 1, p. 12-17 6 p.

Research output: Contribution to journalArticle

Open Access
66 Scopus citations

Ileo-colonic delivery of conjugated bile acids improves glucose homeostasis via colonic GLP-1-producing enteroendocrine cells in human obesity and diabetes

Calderon, G., McRae, A., Rievaj, J., Davis, J., Zandvakili, I., Linker-Nord, S., Burton, D., Roberts, G., Reimann, F., Gedulin, B., Vella, A., LaRusso, N. F., Camilleri, M., Gribble, F. M. & Acosta, A., May 2020, In : EBioMedicine. 55, 102759.

Research output: Contribution to journalArticle

Open Access

Immortalized liver endothelial cells: A cell culture model for studies of motility and angiogenesis

Huebert, R. C., Jagavelu, K., Liebl, A. F., Huang, B. Q., Splinter, P. L., Larusso, N. F., Urrutia, R. A. & Shah, V. H., Dec 1 2010, In : Laboratory Investigation. 90, 12, p. 1770-1781 12 p.

Research output: Contribution to journalArticle

40 Scopus citations

Immunohistologic labeling as an indicator of liver allograft rejection

Perkins, J. D., Wiesner, R. H., Banks, P. M., Larusso, N. F., Ludwig, J. & Krom, R. A. F., Jan 1987, In : Transplantation. 43, 1, p. 105-107 3 p.

Research output: Contribution to journalArticle

24 Scopus citations

Immunohistologic labeling of infiltrating T lymphocytes in hepatic allografts: a rejection indicator.

Perkins, J. D., Wiesner, R. H., Banks, P. M., LaRusso, N. F. & Krom, R. A., Feb 1 1987, In : Transplantation proceedings. 19, 1 Pt 3, p. 2474-2475 2 p.

Research output: Contribution to journalArticle

6 Scopus citations

Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism

Jaiswal, M., LaRusso, N. F., Burgart, L. J. & Gores, G. J., Jan 1 2000, In : Cancer research. 60, 1, p. 184-190 7 p.

Research output: Contribution to journalArticle

503 Scopus citations

Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent models of polycystic kidney and liver disease

Masyuk, T. V., Radtke, B. N., Stroope, A. J., Banales, J. M., Masyuk, A. I., Gradilone, S. A., Gajdos, G. B., Chandok, N., Bakeberg, J. L., Ward, C. J., Ritman, E. L., Kiyokawa, H. & Larusso, N. F., Mar 2012, In : Gastroenterology. 142, 3, p. 622-633.e4

Research output: Contribution to journalArticle

27 Scopus citations

Inhibition of cholesterol crystal formation by apolipoproteins in supersaturated model bile

Kibe, A., Holzbach, R. T., Larusso, N. F. & Mao, S. J. T., Jan 1 1984, In : Science. 225, 4661, p. 514-516 3 p.

Research output: Contribution to journalArticle

160 Scopus citations

Inhibition of metalloprotease hyperactivity in cystic cholangiocytes halts the development of polycystic liver diseases

Urribarri, A. D., Munoz-Garrido, P., Perugorria, M. J., Erice, O., Merino-Azpitarte, M., Arbelaiz, A., Lozano, E., Hijona, E., Jiménez-Agüero, R., Fernandez-Barrena, M. G., Jimeno, J. P., Marzioni, M., Marin, J. J. G., Masyuk, T. V., LaRusso, N. F., Prieto, J., Bujanda, L. & Banales, J. M., Oct 1 2014, In : Gut. 63, 10, p. 1658-1667 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

In primary sclerosing cholangitis, gallbladder polyps are frequently malignant

Buckles, D. C., Lindor, K. D., LaRusso, N. F., Petrovic, L. M. & Gores, G. J., May 18 2002, In : American Journal of Gastroenterology. 97, 5, p. 1138-1142 5 p.

Research output: Contribution to journalArticle

135 Scopus citations

Insignificant effect of secretin in rodent models of polycystic kidney and liver disease

Wang, X., Ye, H., Ward, C. J., Chu, J. Y. S., Masyuk, T. V., Larusso, N. F., Harris, P. C., Chow, B. K. C. & Torres, V. E., Jan 1 2012, In : American Journal of Physiology - Renal Physiology. 303, 7, p. F1089-F1098

Research output: Contribution to journalArticle

11 Scopus citations

Interaction of metronidazole with nucleic acids in vitro

LaRusso, N. F., Tomasz, M., Muller, M. & Lipman, R., Dec 1 1977, In : Molecular pharmacology. 13, 5, p. 872-882 11 p.

Research output: Contribution to journalArticle

94 Scopus citations

Intrahepatic bile ducts transport water in response to absorbed glucose

Masyuk, A. I., Masyuk, T. V., Tietz, P. S., Splinter, P. L. & Larusso, N. F., Sep 2002, In : American Journal of Physiology - Cell Physiology. 283, 3 52-3, p. C785-C791

Research output: Contribution to journalArticle

35 Scopus citations

Intrahepatic cholangiectases and large‐duct obliteration in primary sclerosing cholangitis

Ludwig, J., Maccarty, R. L., Larusso, N. F., Krom, R. A. F. & Wiesner, R. H., Jan 1 1986, In : Hepatology. 6, 4, p. 560-568 9 p.

Research output: Contribution to journalArticle

57 Scopus citations

Isolation and characterization of cholangiocyte primary cilia

Huang, B. Q., Masyuk, T. V., Muff, M. A., Tietz, P. S., Masyuk, A. I. & LaRusso, N. F., Sep 11 2006, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 291, 3, p. G500-G509

Research output: Contribution to journalArticle

64 Scopus citations

Isolation and characterization of lipid microdomains from apical and basolateral plasma membranes of rat hepatocytes

Mazzone, A., Tietz, P., Jefferson, J., Pagano, R. & LaRusso, N. F., Feb 1 2006, In : Hepatology. 43, 2, p. 287-296 10 p.

Research output: Contribution to journalArticle

63 Scopus citations

Isolation and Characterization of Rat Cholangiocyte Vesicles Enriched in Apical or Basolateral Plasma Membrane Domains

Tietz, P. S., Holman, R. T., Miller, L. J. & LaRusso, N. F., Nov 1995, In : Biochemistry. 34, 47, p. 15436-15443 8 p.

Research output: Contribution to journalArticle

55 Scopus citations

Isolation and morphologic characterization of bile duct epithelial cells from normal rat liver

Ishii, M., Vroman, B. & LaRusso, N. F., Nov 1989, In : Gastroenterology. 97, 5, p. 1236-1247 12 p.

Research output: Contribution to journalArticle

177 Scopus citations

Isolation of primary cilia for morphological analysis.

Huang, B., Masyuk, T. & LaRusso, N., 2009, In : Methods in cell biology. 94, p. 103-115 13 p.

Research output: Contribution to journalArticle

6 Scopus citations

Isolation of the microtubule-vesicle motor kinesin from rat liver: Selective inhibition by cholestatic bile acids

Marks, D. L., LaRusso, N. F. & McNiven, M. A., Mar 1995, In : Gastroenterology. 108, 3, p. 824-833 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Is primary sclerosing cholangitis a progressive disease or not?

Wiesner, R. H., Grambsch, P., Larusso, N. F. & Dickson, E. R., 1988, In : Hepatology. 8, 4, p. 970-972 3 p.

Research output: Contribution to journalArticle

17 Scopus citations

Kinetic and molecular identification of sodium-dependent glucose transporter in normal rat cholangiocytes

Lazaridis, K. N., Pham, L., Vroman, B., De Groen, P. C. & LaRusso, N. F., May 1997, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 272, 5 35-5, p. G1168-G1174

Research output: Contribution to journalArticle

54 Scopus citations

Lack of metabolic effects of cholecystokinin on hepatocytes

Kost, L. J., Gores, G. J., Sayles, J. M., Miller, L. J., Lemasters, J. J., Herman, B. & Larusso, N. F., Aug 1990, In : Hepatology. 12, 2, p. 301-305 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism

Sheth, P., Delos Santos, N., Seth, A., LaRusso, N. F. & Rao, R. K., Jul 1 2007, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 293, 1, p. G308-G318

Research output: Contribution to journalArticle

93 Scopus citations

Localized glucose and water influx facilitates Cryptosporidium parvum cellular invasion by means of modulation of host-cell membrane protrusion

Chen, X. M., O'Hara, S. P., Huang, B. Q., Splinter, P. L., Nelson, J. B. & LaRusso, N. F., May 3 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 18, p. 6338-6343 6 p.

Research output: Contribution to journalArticle

70 Scopus citations