• 27712 Citations
  • 95 Scopus h-Index
1973 …2020

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Article

Changes in Liver Stiffness, Measured by Magnetic Resonance Elastography, Associated With Hepatic Decompensation in Patients With Primary Sclerosing Cholangitis

Eaton, J. E., Sen, A., Hoodeshenas, S., Schleck, C. D., Harmsen, W. S., Gores, G. J., LaRusso, N. F., Gossard, A. A., Lazaridis, K. N. & Venkatesh, S. K., Jun 2020, In : Clinical Gastroenterology and Hepatology. 18, 7, p. 1576-1583.e1

Research output: Contribution to journalArticle

2 Scopus citations

Channel-mediated water movement across enclosed or perfused mouse intrahepatic bile duct units

Gong, A. Y., Masyuk, A. I., Splinter, P. L., Huebert, R. C., Tietz, P. S. & Larusso, N. F., Jul 3 2002, In : American Journal of Physiology - Cell Physiology. 283, 1 52-1, p. C338-C346

Research output: Contribution to journalArticle

19 Scopus citations
14 Scopus citations

Characterization of apical and basolateral plasma membrane domains derived from cultured rat cholangiocytes

Tietz, P., Levine, S., Holman, R., Fretham, C. & Larusso, N. F., Dec 15 1997, In : Analytical Biochemistry. 254, 2, p. 192-199 8 p.

Research output: Contribution to journalArticle

23 Scopus citations

Characterization of cultured cholangiocytes isolated from livers of patients with primary sclerosing cholangitis

Tabibian, J. H., Trussoni, C. E., O'Hara, S. P., Splinter, P. L., Heimbach, J. K. & LaRusso, N. F., Jan 1 2014, In : Laboratory Investigation. 94, 10, p. 1126-1133 8 p.

Research output: Contribution to journalArticle

40 Scopus citations

Characterization of PKD protein-positive exosome-like vesicles

Hogan, M. C., Manganelli, L., Woollard, J. R., Masyuk, A. I., Masyuk, T. V., Tammachote, R., Huang, B. Q., Leontovich, A. A., Beito, T. G., Madden, B. J., Charlesworth, M. C., Torres, V. E., Larusso, N. F., Harris, P. C. & Ward, C. J., Feb 1 2009, In : Journal of the American Society of Nephrology. 20, 2, p. 278-288 11 p.

Research output: Contribution to journalArticle

197 Scopus citations

Charcoal hemoperfusion in the treatment of medically refractory pruritus in cholestatic liver disease

Kittanamongkolchai, W., El-Zoghby, Z. M., Eileen Hay, J., Wiesner, R. H., Kamath, P. S., La Russo, N. F., Watt, K. D., Cramer, C. H. & Leung, N., Dec 8 2016, (Accepted/In press) In : Hepatology International. p. 1-6 6 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cholangiocarcinoma complicating primary sclerosing cholangitis: Cholangiographic appearances

MacCarty, R. L., LaRusso, N. F., May, G. R., Bender, C. E., Wiesner, R. H., King, J. E. & Coffey, R. J., Jan 1 1985, In : Radiology. 156, 1, p. 43-46 4 p.

Research output: Contribution to journalArticle

103 Scopus citations

Cholangiocarcinoma complicating primary sclerosing cholangitis

Rosen, C. B., Nagorney, D. M., Wiesner, R. H., Coffey, R. J. & Larusso, N. F., Jan 1991, In : Annals of surgery. 213, 1, p. 21-25 5 p.

Research output: Contribution to journalArticle

304 Scopus citations

Cholangiocarcinomas express Fas ligand and disable the Fas receptor

Que, F. G., Phan, V. A., Phan, V. H., Celli, A., Batts, K., LaRusso, N. F. & Gores, G. J., Jan 1 1999, In : Hepatology. 30, 6, p. 1398-1404 7 p.

Research output: Contribution to journalArticle

65 Scopus citations

Cholangiocyte autophagy contributes to hepatic cystogenesis in polycystic liver disease and represents a potential therapeutic target

Masyuk, A. I., Masyuk, T. V., Lorenzo Pisarello, M. J., Ding, J. F., Loarca, L., Huang, B. Q. & La Russo, N. F., Jan 1 2018, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

13 Scopus citations

Cholangiocyte bile salt transporters in cholesterol gallstone-susceptible and resistant inbred mouse strains

Liu, J. J., Glickman, J. N., Masyuk, A. I. & LaRusso, N. F., Oct 2008, In : Journal of Gastroenterology and Hepatology (Australia). 23, 10, p. 1596-1602 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cholangiocyte Cilia Detect Changes in Luminal Fluid Flow and Transmit Them Into Intracellular Ca2+ and cAMP Signaling

Masyuk, A. I., Masyuk, T. V., Splinter, P. L., Huang, B. Q., Stroope, A. J. & LaRusso, N. F., Sep 2006, In : Gastroenterology. 131, 3, p. 911-920 10 p.

Research output: Contribution to journalArticle

184 Scopus citations

Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion

Gradilone, S. A., Masyuk, A. I., Splinter, P. L., Banales, J. M., Huang, B. Q., Tietz, P. S., Masyuk, T. V. & LaRusso, N. F., Nov 27 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 48, p. 19138-19143 6 p.

Research output: Contribution to journalArticle

134 Scopus citations

Cholangiocyte myosin IIB is required for localized aggregation of sodium glucose cotransporter 1 to sites of Cryptosporidium parvum cellular invasion and facilitates parasite internalization

O'Hara, S. P., Gajdos, G. B., Trussoni, C. E., Splinter, P. L. & LaRusso, N. F., Jul 1 2010, In : Infection and Immunity. 78, 7, p. 2927-2936 10 p.

Research output: Contribution to journalArticle

9 Scopus citations

Cholangiocyte N-Ras protein mediates lipopolysaccharide-induced interleukin 6 secretion and proliferation

O'Hara, S. P., Splinter, P. L., Trussoni, C. E., Gajdos, G. B., Lineswala, P. N. & LaRusso, N. F., Sep 2 2011, In : Journal of Biological Chemistry. 286, 35, p. 30352-30360 9 p.

Research output: Contribution to journalArticle

44 Scopus citations

Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors

Masyuk, A. I., Gradilone, S. A., Banales, J. M., Huang, B. Q., Masyuk, T. V., Lee, S. O., Splinter, P. L., Stroope, A. J. & LaRusso, N. F., Oct 1 2008, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 4, p. G725-G734

Research output: Contribution to journalArticle

109 Scopus citations

Cholangiocytes and the environment in primary sclerosing cholangitis: Where is the link?

O'Hara, S. P., Karlsen, T. H. & La Russo, N. F., Nov 1 2017, In : Gut. 66, 11, p. 1873-1877 5 p.

Research output: Contribution to journalArticle

8 Scopus citations

Cholangiocyte senescence by way of N-Ras activation is a characteristic of primary sclerosing cholangitis

Tabibian, J. H., O'Hara, S. P., Splinter, P. L., Trussoni, C. E. & Larusso, N. F., Jun 2014, In : Hepatology. 59, 6, p. 2263-2275 13 p.

Research output: Contribution to journalArticle

96 Scopus citations

Cholangiocytes express the aquaporin CHIP and transport water via a channel-mediated mechanism

Roberts, S. K., Yano, M., Ueno, Y., Pham, L., Alpini, G., Agre, P. & Larusso, N. F., Dec 20 1994, In : Proceedings of the National Academy of Sciences of the United States of America. 91, 26, p. 13009-13013 5 p.

Research output: Contribution to journalArticle

108 Scopus citations

Cholangiocyte-specific rat liver proteins identified by establishment of a two-dimensional gel protein database

Tietz, P., De Groen, P. C., Anderson, N. L., Sims, C., Esquer-Blasco, R., Meheus, L., Raymackers, J., Dauwe, M. & Larusso, N. F., Dec 1 1998, In : Electrophoresis. 19, 18, p. 3207-3212 6 p.

Research output: Contribution to journalArticle

11 Scopus citations

Cholelitholysis Using Methyl Tertiary Butyl Ether

Allen, M. J., Borody, T. J., Bugliosi, T. F., May, G. R., Larusso, N. F. & Thistle, J. L., Jan 1 1985, In : Gastroenterology. 88, 1, p. 122-125 4 p.

Research output: Contribution to journalArticle

97 Scopus citations

Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling

Masyuk, A. I., Huang, B. Q., Radtke, B. N., Gajdos, G. B., Splinter, P. L., Masyuk, T. V., Gradilone, S. A. & LaRusso, N. F., Jun 11 2013, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 11, p. G1013-G1024

Research output: Contribution to journalArticle

64 Scopus citations

Circadian rhythms of biliary protein and lipid excretion in rats

Nakano, A., Tietz, P. S. & LaRusso, N. F., Jan 1 1990, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 258, 5 21-5, p. G653-G659

Research output: Contribution to journalArticle

33 Scopus citations

Clinicopathological correlates of aspartyl (asparaginyl) β-hydroxylase over-expression in cholangiocarcinoma

Maeda, T., Taguchi, K. I., Aishima, S. I., Shimada, M., Hintz, D., Larusso, N., Gores, G., Tsuneyoshi, M., Sugimachi, K., Wands, J. R. & Monte, S. M. D. L., Nov 19 2004, In : Cancer Detection and Prevention. 28, 5, p. 313-318 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Clinicopathologic features of the syndrome of primary sclerosing cholangitis

Wiesner, R. H. & LaRusso, N. F., Jan 1 1980, In : Gastroenterology. 79, 2, p. 200-206 7 p.

Research output: Contribution to journalArticle

484 Scopus citations

Cloning and expression of SLC10A4, a putative organic anion transport protein

Splinter, P. L., Lazaridis, K. N., Dawson, P. A. & LaRusso, N. F., Nov 14 2006, In : World journal of gastroenterology. 12, 42, p. 6797-6805 9 p.

Research output: Contribution to journalArticle

Open Access
17 Scopus citations

Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease

Lorenzo Pisarello, M., Masyuk, T. V., Gradilone, S. A., Masyuk, A. I., Ding, J. F., Lee, P. Y. & LaRusso, N. F., Apr 2018, In : American Journal of Pathology. 188, 4, p. 981-994 14 p.

Research output: Contribution to journalArticle

4 Scopus citations

Comparison of surgical treatment of ulcerative colitis associated with primary sclerosing cholangitis: Heal pouch-anal anastomosis versus brooke ileostomy

Kartheuser, A. H., Dozois, R. R., Larusso, N. F., Wiesner, R. H., Ilstrup, D. M. & Schleck, C. D., Jan 1 1996, In : Mayo Clinic proceedings. 71, 8, p. 748-756 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Comparison of the Clinicopathologic Features of Primary Sclerosing Chol-angitis and Primary Biliary Cirrhosis

Wiesner, R. H., Larusso, N. F., Ludwig, J. & Rolland Dickson, E., Jan 1 1985, In : Gastroenterology. 88, 1, p. 108-114 7 p.

Research output: Contribution to journalArticle

171 Scopus citations

Complications and risk factors after heal pouch-anal anastomosis for ulcerative colitis associated with primary sclerosing cholangitis

Kartheuser, A. H., Dozois, R. R., Wiesner, R. H., LaRusso, N. F., Ilstrup, D. M. & Schleck, C. D., Apr 1993, In : Annals of surgery. 217, 4, p. 314-320 7 p.

Research output: Contribution to journalArticle

51 Scopus citations

COMPLICATIONS ET FACTEURS DE RISQUE DE L'ANASTOMOSE ILEO-ANALE AVEC RESERVOIR POUR RECTOCOLIE ULCERO-HEMORRAGIQUE ASSOCIEE A UNE CHOLANGITE SCLEROSANTE PRIMITIVE

Translated title of the contribution: Complications and risk factors after ileal pouch-anal anastomosis for ulcerative colitis associated with primary sclerosing cholangitisKartheuser, A. H., Dozois, R. R., Wiesner, R. H., La Russo, N. F., Ilstrup, D. M. & Schleck, C. D., Dec 1 1993, In : Annales de Chirurgie. 47, 10, p. 1000-1008 9 p.

Research output: Contribution to journalArticle

1 Scopus citations

Computed tomography and peritoneoscopy for detection of liver metastases: Review of mayo clinic experience

Danielson, K. S., Sheedy, P. F., Stephens, D. H., Hattery, R. R. & Larusso, N. F., Apr 1983, In : Journal of computer assisted tomography. 7, 2, p. 230-234 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Coordinate secretion of acid hydrolases in rat bile. Hepatocyte exocytosis of lysosomal protein?

LaRusso, N. F. & Fowler, S., Jan 1 1979, In : Journal of Clinical Investigation. 64, 4, p. 948-954 7 p.

Research output: Contribution to journalArticle

Open Access
69 Scopus citations

Correspondence. Circulating Immune Complexes in Primary Sclerosing Cholangitis

Mihas, A. A., Volanakis, J. E., Schrohenloher, R. E., Mihas, T. A., Bodenheimer, H. C., La Russo, N. F., Thayer, W. R., Charland, C., Staples, P. J., Ludwig, J., Roggendorf, M., Deinhardt, F. & FrÖSner, G. G., 1984, In : Hepatology. 4, 2, p. 351-354 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Cryptosporidium parvum activates nuclear factor κB in biliary epithelia preventing epithelial cell apoptosis

Chen, X. M., Levine, S. A., Splinter, P. L., Tietz, P. S., Ganong, A. L., Jobin, C., Gores, G. J., Paya, C. V. & LaRusso, N. F., Jan 1 2001, In : Gastroenterology. 120, 7, p. 1774-1783 10 p.

Research output: Contribution to journalArticle

94 Scopus citations

Cryptosporidium parvum attachment to and internalization by human biliary epithelia in vitro: A morphologic study

Huang, B. Q., Chen, X. M. & LaRusso, N. F., Apr 1 2004, In : Journal of Parasitology. 90, 2, p. 212-221 10 p.

Research output: Contribution to journalArticle

59 Scopus citations
84 Scopus citations

Cryptosporidium parvum infects human cholangiocytes via sphingolipid-enriched membrane microdomains

Nelson, J. B., O'hara, S. P., Small, A. J., Tietz, P. S., Choudhury, A. K., Pagano, R. E., Chen, X. M. & Larusso, N. F., Dec 1 2006, In : Cellular Microbiology. 8, 12, p. 1932-1945 14 p.

Research output: Contribution to journalArticle

29 Scopus citations

Cryptosporidium parvum invasion of biliary epithelia requires host cell tyrosine phosphorylation of cortactin via c-Src

Chen, X. M., Huang, B. Q., Splinter, P. L., Cao, H., Zhu, G., McNiven, M. A. & Larusso, N. F., Jul 1 2003, In : Gastroenterology. 125, 1, p. 216-228 13 p.

Research output: Contribution to journalArticle

56 Scopus citations

Cryptosporidium parvum is cytopathic for cultured human biliary epithelia via an apoptotic mechanism

Chen, X. M., Levine, S. A., Tietz, P., Krueger, E., McNiven, M. A., Jefferson, D. M., Mahle, M. & LaRusso, N. F., Oct 13 1998, In : Hepatology. 28, 4 I, p. 906-913 8 p.

Research output: Contribution to journalArticle

68 Scopus citations

Cyclic AMP Regulates Bicarbonate Secretion in Cholangiocytes Through Release of ATP Into Bile

Minagawa, N., Nagata, J., Shibao, K., Masyuk, A. I., Gomes, D. A., Rodrigues, M. A., Lesage, G., Akiba, Y., Kaunitz, J. D., Ehrlich, B. E., Larusso, N. F. & Nathanson, M. H., Nov 2007, In : Gastroenterology. 133, 5, p. 1592-1602 11 p.

Research output: Contribution to journalArticle

93 Scopus citations

Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes

Spirlì, C., Fabris, L., Duner, E., Fiorotto, R., Ballardini, G., Roskams, T., Larusso, N. F., Sonzogni, A., Okolicsanyi, L. & Strazzabosco, M., Mar 1 2003, In : Gastroenterology. 124, 3, p. 737-753 17 p.

Research output: Contribution to journalArticle

104 Scopus citations

Cytoskeletal and motor proteins facilitate trafficking of AQP1-containing vesicles in cholangiocytes

Tietz, P. S., McNiven, M. A., Splinter, P. L., Huang, B. Q. & LaRusso, N. F., Jan 1 2006, In : Biology of the Cell. 98, 1, p. 43-52 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Defects in Cholangiocyte Fibrocystin Expression and Ciliary Structure in the PCK Rat

Masyuk, T. V., Huang, B. Q., Ward, C. J., Masyuk, A. I., Yuan, D., Splinter, P. L., Punyashthiti, R., Ritman, E. L., Torres, V. E., Harris, P. C. & Larusso, N. F., Nov 2003, In : Gastroenterology. 125, 5, p. 1303-1310 8 p.

Research output: Contribution to journalArticle

140 Scopus citations

Deoxycholic acid, but not chenodeoxycholic and cholic acids, inhibits intestinal absorption of cholesterol in man

Sama, C. & LaRusso, N. F., Jan 1 1980, In : Gastroenterology. 78, 5 II, 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Determinants of fasting and postprandial serum bile acid levels in healthy man

LaRusso, N. F., Hoffman, N. E., Korman, M. G., Hofmann, A. F. & Cowen, A. E., May 1978, In : The American Journal of Digestive Diseases. 23, 5, p. 385-391 7 p.

Research output: Contribution to journalArticle

75 Scopus citations

Development and application of methodology for assessing the role of lysosomes in experimental ulcerogenesis in the guinea pig

Nagorney, D. M., LaRusso, N. F. & Dozois, R. R., Sep 1983, In : Gastroenterology. 85, 3, p. 548-556 9 p.

Research output: Contribution to journalArticle

Open Access
6 Scopus citations

Development and characterization of a cholangiocyte cell line from the PCK rat, an animal model of Autosomal Recessive Polycystic Kidney Disease

Muff, M. A., Masyuk, T. V., Stroope, A. J., Huang, B. Q., Splinter, P. L., Lee, S. O. & LaRusso, N. F., Sep 5 2006, In : Laboratory Investigation. 86, 9, p. 940-950 11 p.

Research output: Contribution to journalArticle

28 Scopus citations

Development and characterization of a rodent model of immune-mediated cholangitis

Ueno, Y., Phillips, J. O., Ludwig, J., Lichtman, S. N. & LaRusso, N. F., Jan 9 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 1, p. 216-220 5 p.

Research output: Contribution to journalArticle

33 Scopus citations