• 4304 Citations
  • 37 Scopus h-Index
19952019
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Research Output 1995 2019

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Article
2019

Accurate patient-specific machine learning models of glioblastoma invasion using transfer learning

Hu, L. S., Yoon, H., Eschbacher, J. M., Baxter, L. C., Dueck, A., Nespodzany, A., Smith, K. A., Nakaji, P., Xu, Y., Wang, L., Karis, J. P., Hawkins-Daarud, A. J., Singleton, K. W., Jackson, P. R., Anderies, B. J., Bendok, B., Zimmerman, R. S., Quarles, C., Porter-Umphrey, A. B., Mrugala, M. M. & 11 others, Sharma, A., Hoxworth, J. M., Sattur, M. G., Sanai, N., Koulemberis, P. E., Krishna, C., Mitchell, J. R., Wu, T., Tran, N., Swanson, K. & Li, J., Jan 1 2019, In : American Journal of Neuroradiology. 40, 3, p. 418-425 8 p.

Research output: Contribution to journalArticle

Open Access
Glioblastoma
Cell Count
Neoplasms
Image-Guided Biopsy
Diffusion Tensor Imaging
17 Citations (Scopus)

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Bryant, K. L., Stalnecker, C. A., Zeitouni, D., Klomp, J. E., Peng, S., Tikunov, A. P., Gunda, V., Pierobon, M., Waters, A. M., George, S. D., Tomar, G., Papke, B., Hobbs, G. A., Yan, L., Hayes, T. K., Diehl, J. N., Goode, G. D., Chaika, N. V., Wang, Y., Zhang, G. F. & 11 others, Witkiewicz, A. K., Knudsen, E. S., Petricoin, E. F., Singh, P. K., Macdonald, J. M., Tran, N., Lyssiotis, C. A., Ying, H., Kimmelman, A. C., Cox, A. D. & Der, C. J., Apr 1 2019, In : Nature Medicine. 25, 4, p. 628-640 13 p.

Research output: Contribution to journalArticle

Autophagy
Chloroquine
Pancreatic Neoplasms
Fluxes
Adenocarcinoma
1 Citation (Scopus)

Germline predisposition and copy number alteration in pre-stage lung adenocarcinomas presenting as ground-glass nodules

Ren, Y., Huang, S., Dai, C., Xie, D., Zheng, L., Xie, H., Zheng, H., She, Y., Zhou, F., Wang, Y., Li, P., Fei, K., Jiang, G., Zhang, Y., Su, B., Alejandro Sweet-Cordero, E., Tran, N., Yang, Y. D., Patel, J. N., Rolfo, C. & 7 others, Rocco, G., Cardona, A. F., Tuzi, A., Suter, M. B., Yang, P., Xu, W. & Chen, C., Jan 1 2019, In : Frontiers in Oncology. 9, MAR, 288.

Research output: Contribution to journalArticle

Open Access
Glass
Germ-Line Mutation
Mutation
Exome
Mutagens

Leveraging spatial variation in tumor purity for improved somatic variant calling of archival tumor only samples

Halperin, R. F., Liang, W. S., Kulkarni, S., Tassone, E. E., Adkins, J., Enriquez, D., Tran, N., Hank, N. C., Newell, J., Kodira, C., Korn, R., Berens, M. E., Kim, S. & Byron, S. A., Jan 1 2019, In : Frontiers in Oncology. 9, MAR

Research output: Contribution to journalArticle

Open Access
Neoplasms
Exome
Translational Medical Research
Glioblastoma
Genomics
2018
4 Citations (Scopus)

A Novel Signaling Complex between TROY and EGFR Mediates Glioblastoma Cell Invasion

Ding, Z., Roos, A., Kloss, J., Dhruv, H., Peng, S., Pirrotte, P., Eschbacher, J. M., Tran, N. & Loftus, J. C., Feb 1 2018, In : Molecular Cancer Research. 16, 2, p. 322-332 11 p.

Research output: Contribution to journalArticle

Glioblastoma
temozolomide
Neoplasms
Epidermal Growth Factor
Survival
1 Citation (Scopus)

Differential expression of the TWEAK receptor Fn14 in IDH1 wild-type and mutant gliomas

Hersh, D. S., Peng, S., Dancy, J. G., Galisteo, R., Eschbacher, J. M., Castellani, R. J., Heath, J. E., Legesse, T., Kim, A. J., Woodworth, G. F., Tran, N. & Winkles, J. A., Feb 16 2018, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Glioma
Glioblastoma
decitabine
TWEAK receptor
1 Citation (Scopus)

EGFRvIII–Stat5 signaling enhances glioblastoma cell migration and survival

Roos, A., Dhruv, H. D., Peng, S., Inge, L. J., Tuncali, S., Pineda, M., Millard, N., Mayo, Z., Eschbacher, J. M., Loftus, J. C., Winkles, J. A. & Tran, N., Jul 1 2018, In : Molecular Cancer Research. 16, 7, p. 1185-1195 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell Movement
Cell Survival
Neoplasms
Pimozide
14 Citations (Scopus)

Evaluation of pre-analytical factors affecting plasma DNA analysis

Markus, H., Contente-Cuomo, T., Farooq, M., Liang, W. S., Borad, M. J., Sivakumar, S., Gollins, S., Tran, N., Dhruv, H. D., Berens, M. E., Bryce, A. H., Sekulic, A. D., Ribas, A., Trent, J. M., Lorusso, P. M. & Murtaza, M., Dec 1 2018, In : Scientific Reports. 8, 1, 7375.

Research output: Contribution to journalArticle

DNA
cells
sampling
droplets
blood
4 Citations (Scopus)

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

Randall, E. C., Emdal, K. B., Laramy, J. K., Kim, M., Roos, A., Calligaris, D., Regan, M. S., Gupta, S. K., Mladek, A. C., Carlson, B. L., Johnson, A. J., Lu, F. K., Xie, X. S., Joughin, B. A., Reddy, R. J., Peng, S., Abdelmoula, W. M., Jackson, P. R., Kolluri, A., Kellersberger, K. A. & 8 others, Agar, J. N., Lauffenburger, D. A., Swanson, K., Tran, N., Elmquist, W. F., White, F. M., Sarkaria, J. N. & Agar, N. Y. R., Dec 1 2018, In : Nature Communications. 9, 1, 4904.

Research output: Contribution to journalArticle

Pharmacodynamics
Pharmacokinetics
Glioblastoma
Heterografts
drugs

PDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival

Ding, Z., Dhruv, H., Kwiatkowska-Piwowarczyk, A., Ruggieri, R., Kloss, J., Symons, M., Pirrotte, P., Eschbacher, J. M., Tran, N. & Loftus, J. C., Oct 1 2018, In : Neoplasia (United States). 20, 10, p. 1045-1058 14 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
Glioblastoma
Cell Survival
Glioma
Cell Movement
17 Citations (Scopus)

Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma

Byron, S. A., Tran, N., Halperin, R. F., Phillips, J. J., Kuhn, J. G., De Groot, J. F., Colman, H., Ligon, K. L., Wen, P. Y., Cloughesy, T. F., Mellinghoff, I. K., Butowski, N. A., Taylor, J. W., Clarke, J. L., Chang, S. M., Berger, M. S., Molinaro, A. M., Maggiora, G. M., Peng, S., Nasser, S. & 6 others, Liang, W. S., Trent, J. M., Berens, M. E., Carpten, J. D., Craig, D. W. & Prados, M. D., Jan 15 2018, In : Clinical Cancer Research. 24, 2, p. 295-305 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Genomics
Therapeutics
Exome
RNA Sequence Analysis
1 Citation (Scopus)

The TNF receptor family member Fn14 is highly expressed in recurrent glioblastoma and in GBM patient-derived xenografts with acquired temozolomide resistance

Hersh, D. S., Harder, B. G., Roos, A., Peng, S., Heath, J. E., Legesse, T., Kim, A. J., Woodworth, G. F., Tran, N. & Winkles, J. A., Jan 1 2018, In : Neuro-Oncology. 20, 10, p. 1321-1330 10 p.

Research output: Contribution to journalArticle

temozolomide
Tumor Necrosis Factor Receptors
Glioblastoma
Heterografts
Gliosarcoma
2017
10 Citations (Scopus)

Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells

Roos, A., Dhruv, H. D., Mathews, I. T., Inge, L. J., Tuncali, S., Hartman, L. K., Chow, D., Millard, N., Yin, H. H., Kloss, J., Loftus, J. C., Winkles, J. A., Berens, M. E. & Tran, N., 2017, In : Oncotarget. 8, 7, p. 12234-12246 13 p.

Research output: Contribution to journalArticle

Aurintricarboxylic Acid
Glioblastoma
Glioma
temozolomide
Cell Survival
6 Citations (Scopus)

Integrated genomic analysis of survival outliers in glioblastoma

Peng, S., Dhruv, H., Armstrong, B., Salhia, B., Legendre, C., Kiefer, J., Parks, J., Virk, S., Sloan, A. E., Ostrom, Q. T., Barnholtz-Sloan, J. S., Tran, N. & Berens, M. E., 2017, In : Neuro-Oncology. 19, 6, p. 833-844 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Survival Analysis
Mitogen-Activated Protein Kinase 1
temozolomide
Methylation
1 Citation (Scopus)

MTCTScan: A comprehensive platform for annotation and prioritization of mutations affecting drug sensitivity in cancers

Li, M. J., Yao, H., Huang, D., Liu, H., Liu, Z., Xu, H., Qin, Y., Prinz, J., Xia, W., Wang, P., Yan, B., Tran, N., Kocher, J-P., Sham, P. C. & Wang, J., Jul 3 2017, In : Nucleic Acids Research. 45, W1, p. W215-W221

Research output: Contribution to journalArticle

Mutation
Pharmaceutical Preparations
Neoplasms
Therapeutics
Precision Medicine
39 Citations (Scopus)

Radiogenomics to characterize regional genetic heterogeneity in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Baxter, L. C., Gaw, N., Ranjbar, S., Plasencia, J., Dueck, A., Peng, S., Smith, K. A., Nakaji, P., Karis, J. P., Quarles, C. C., Wu, T., Loftus, J. C., Jenkins, R. B., Sicotte, H., Kollmeyer, T. M., O'Neill, B. P., Elmquist, W. & 7 others, Hoxworth, J. M., Frakes, D., Sarkaria, J. N., Swanson, K., Tran, N., Li, J. & Mitchell, J. R., 2017, In : Neuro-Oncology. 19, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Glioblastoma
erbB-1 Genes
Neoplasms
Biopsy
19 Citations (Scopus)

RNA sequencing and transcriptome arrays analyses show opposing results for alternative splicing in patient derived samples

Nazarov, P. V., Muller, A., Kaoma, T., Nicot, N., Maximo, C., Birembaut, P., Tran, N., Dittmar, G. & Vallar, L., Jun 6 2017, In : BMC Genomics. 18, 1, 443.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Alternative Splicing
Gene Expression Profiling
Long Noncoding RNA
Exons
2016
4 Citations (Scopus)

Pharmacological Inhibition of the Protein Kinase MRK/ZAK Radiosensitizes Medulloblastoma

Markowitz, D., Powell, C., Tran, N., Berens, M. E., Ryken, T. C., Vanan, M., Rosen, L., He, M., Sun, S., Symons, M., Al-Abed, Y. & Ruggieri, R., Aug 1 2016, In : Molecular Cancer Therapeutics. 15, 8, p. 1799-1808 10 p.

Research output: Contribution to journalArticle

Medulloblastoma
Protein Kinases
Pharmacology
Radiation
Cell Cycle Checkpoints
5 Citations (Scopus)

Propentofylline inhibits glioblastoma cell invasion and survival by targeting the TROY signaling pathway

Dhruv, H. D., Roos, A., Tomboc, P. J., Tuncali, S., Chavez, A., Mathews, I., Berens, M. E., Loftus, J. C. & Tran, N., Feb 1 2016, In : Journal of Neuro-Oncology. 126, 3, p. 397-404 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell Survival
temozolomide
Glioma
Alzheimer Disease
9 Citations (Scopus)

SGEF is regulated via TWEAK/Fn14/NF-κB signaling and promotes survival by modulation of the DNA repair response to temozolomide

Fortin Ensign, S. P., Roos, A., Mathews, I. T., Dhruv, H. D., Tuncali, S., Sarkaria, J. N., Symons, M. H., Loftus, J. C., Berens, M. E. & Tran, N., Mar 1 2016, In : Molecular Cancer Research. 14, 3, p. 302-312 11 p.

Research output: Contribution to journalArticle

temozolomide
DNA Repair
Glioblastoma
Glioma
Therapeutics
13 Citations (Scopus)

Tumor-targeted nanotherapeutics: Overcoming treatment barriers for glioblastoma

Wadajkar, A. S., Dancy, J. G., Hersh, D. S., Anastasiadis, P., Tran, N., Woodworth, G. F., Winkles, J. A. & Kim, A. J., 2016, (Accepted/In press) In : Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology.

Research output: Contribution to journalArticle

Glioblastoma
Epidermal Growth Factor Receptor
Tumors
Interleukin-13 Receptors
Proteins
2015
33 Citations (Scopus)

Multi-parametric MRI and texture analysis to visualize spatial histologic heterogeneity and tumor extent in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Gaw, N., Dueck, A., Smith, K. A., Nakaji, P., Plasencia, J., Ranjbar, S., Price, S. J., Tran, N., Loftus, J. C., Jenkins, R. B., O'Neill, B. P., Elmquist, W., Baxter, L. C., Gao, F., Frakes, D., Karis, J. P., Zwart, C. & 5 others, Swanson, K., Sarkaria, J. N., Wu, T., Mitchell, J. R. & Li, J., Nov 1 2015, In : PLoS One. 10, 11, e0141506.

Research output: Contribution to journalArticle

Glioblastoma
Magnetic resonance imaging
Tumors
Textures
texture
58 Citations (Scopus)

Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

Salanti, A., Clausen, T. M., Agerbæk, M. O., Al Nakouzi, N., Dahlbäck, M., Oo, H. Z., Lee, S., Gustavsson, T., Rich, J. R., Hedberg, B. J., Mao, Y., Barington, L., Pereira, M. A., LoBello, J., Endo, M., Fazli, L., Soden, J., Wang, C. K., Sander, A. F., Dagil, R. & 15 others, Thrane, S., Holst, P. J., Meng, L., Favero, F., Weiss, G. J., Nielsen, M. A., Freeth, J., Nielsen, T. O., Zaia, J., Tran, N., Trent, J., Babcook, J. S., Theander, T. G., Sorensen, P. H. & Daugaard, M., Oct 12 2015, In : Cancer Cell. 28, 4, p. 500-514 15 p., 2143.

Research output: Contribution to journalArticle

Glycosaminoglycans
Malaria
Carrier Proteins
Chondroitin Sulfates
Neoplasms
11 Citations (Scopus)

The TWEAK receptor Fn14 is an Src-inducible protein and a positive regulator of Src-driven cell invasion

Cheng, E., Whitsett, T. G., Tran, N. & Winkles, J. A., Mar 1 2015, In : Molecular Cancer Research. 13, 3, p. 575-583 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
src-Family Kinases
Proteins
Gene Expression
Neoplasms
2014
9 Citations (Scopus)

Development of human serine protease-based therapeutics targeting Fn14 and identification of Fn14 as a new target overexpressed in TNBC

Zhou, H., Mohamedali, K. A., Gonzalez-Angulo, A. M., Cao, Y., Migliorini, M., Cheung, L. H., LoBello, J., Lei, X., Qi, Y., Hittelman, W. N., Winkles, J. A., Tran, N. & Rosenblum, M. G., Nov 1 2014, In : Molecular Cancer Therapeutics. 13, 11, p. 2688-2705 18 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Granzymes
Human Development
Serine Proteases
Neoplasms
13 Citations (Scopus)

FN14 expression correlates with MET in NSCLC and promotes MET-driven cell invasion

Whitsett, T. G., Fortin Ensign, S. P., Dhruv, H. D., Inge, L. J., Kurywchak, P., Wolf, K. K., LoBello, J., Kingsley, C. B., Allen, J. W., Weiss, G. J. & Tran, N., 2014, In : Clinical and Experimental Metastasis. 31, 6, p. 613-623 11 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Neoplasms
Proteins
Neoplasm Metastasis
Cell Movement
13 Citations (Scopus)

Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation

Murray, D. W., Didier, S., Chan, A., Paulino, V., Van Aelst, L., Ruggieri, R., Tran, N., Byrne, A. T. & Symons, M., Mar 4 2014, In : British Journal of Cancer. 110, 5, p. 1307-1315 9 p.

Research output: Contribution to journalArticle

Guanine Nucleotide Exchange Factors
Glioblastoma
lissamine rhodamine B
GTP Phosphohydrolase Activators
rho GTP-Binding Proteins
53 Citations (Scopus)

Integrated genomic and epigenomic analysis of breast cancer brain metastasis

Salhia, B., Kiefer, J., Ross, J. T. D., Metapally, R., Martinez, R. A., Johnson, K. N., DiPerna, D. M., Paquette, K. M., Jung, S., Nasser, S., Wallstrom, G., Tembe, W., Baker, A., Carpten, J., Resau, J., Ryken, T., Sibenaller, Z., Petricoin, E. F., Liotta, L. A., Ramanathan, R. K. & 2 others, Berens, M. E. & Tran, N., Jan 29 2014, In : PLoS One. 9, 1, e85448.

Research output: Contribution to journalArticle

Epigenomics
epigenetics
Brain Neoplasms
metastasis
breast neoplasms
10 Citations (Scopus)

LKB1 inactivation sensitizes non-small cell lung cancer to pharmacological aggravation of ER stress

Inge, L. J., Friel, J. M., Richer, A. L., Fowler, A. J., Whitsett, T., Smith, M. A., Tran, N. & Bremner, R. M., Oct 1 2014, In : Cancer Letters. 352, 2, p. 187-195 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Pharmacology
Deoxyglucose
Brefeldin A
Therapeutics
15 Citations (Scopus)

Mcl-1 mediates TWEAK/Fn14-induced non-small cell lung cancer survival and therapeutic response

Whitsett, T. G., Mathews, I. T., Cardone, M. H., Lena, R. J., Pierceall, W. E., Bittner, M., Sima, C., LoBello, J., Weiss, G. J. & Tran, N., 2014, In : Molecular Cancer Research. 12, 4, p. 550-559 10 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Survival
Cell Survival
Therapeutics
Neoplasms
8 Citations (Scopus)

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioblastoma cell chemotaxis via Lyn activation

Dhruv, H. D., Whitsett, T. G., Jameson, N. M., Patel, F., Winkles, J. A., Berens, M. E. & Tran, N., Jan 2014, In : Carcinogenesis. 35, 1, p. 218-226 9 p.

Research output: Contribution to journalArticle

Chemotaxis
Glioblastoma
Glioma
src-Family Kinases
Tumor Necrosis Factor-alpha
2013
6 Citations (Scopus)
Barrett Esophagus
src-Family Kinases
Apoptosis
Cell Line
Growth
35 Citations (Scopus)

IRS1 is highly expressed in localized breast tumors and regulates the sensitivity of breast cancer cells to chemotherapy, while IRS2 is highly expressed in invasive breast tumors

Porter, H. A., Perry, A., Kingsley, C., Tran, N. & Keegan, A. D., Sep 28 2013, In : Cancer Letters. 338, 2, p. 239-248 10 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Drug Therapy
Carcinoma, Intraductal, Noninfiltrating
MCF-7 Cells
Tyrosine
1 Citation (Scopus)

New insights into the functional consequences of ephrin A3 mutations in non-small cell lung cancer

Whitsett, T. G., Loftus, J. C., Winkles, J. A. & Tran, N., 2013, In : Translational Lung Cancer Research. 2, 1, p. 3-5 3 p.

Research output: Contribution to journalArticle

Ephrin-A3
Non-Small Cell Lung Carcinoma
Mutation
27 Citations (Scopus)

Reciprocal Activation of Transcription Factors Underlies the Dichotomy between Proliferation and Invasion of Glioma Cells

Dhruv, H. D., McDonough Winslow, W. S., Armstrong, B., Tuncali, S., Eschbacher, J., Kislin, K., Loftus, J. C., Tran, N. & Berens, M. E., Aug 15 2013, In : PLoS One. 8, 8, e72134.

Research output: Contribution to journalArticle

Glioma
Transcription Factors
transcription factors
Chemical activation
Cells
15 Citations (Scopus)

Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis

Dhruv, H., Loftus, J. C., Narang, P., Petit, J. L., Fameree, M., Burton, J., Tchegho, G., Chow, D., Yin, H., Al-Abed, Y., Berens, M. E., Tran, N. & Meurice, N., Nov 8 2013, In : Journal of Biological Chemistry. 288, 45, p. 32261-32276 16 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Tumor Necrosis Factor-alpha
Apoptosis
Small Molecule Libraries
Molecules
32 Citations (Scopus)

The HER2- and heregulin b1 (HRG)-inducible TNFR superfamily member Fn14 promotes HRG-driven breast cancer cell migration, invasion, and MMP9 expression

Asrani, K., Keri, R. A., Galisteo, R., Brown, S. A. N., Morgan, S. J., Ghosh, A., Tran, N. & Winkles, J. A., Apr 2013, In : Molecular Cancer Research. 11, 4, p. 393-404 12 p.

Research output: Contribution to journalArticle

Neuregulin-1
Cell Movement
Breast Neoplasms
MCF-7 Cells
erbB-2 Genes
20 Citations (Scopus)
TNF Receptor-Associated Factor 2
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Guanine Nucleotide Exchange Factors
src Homology Domains
Fibroblast Growth Factors
32 Citations (Scopus)

The TWEAK receptor Fn14 is a therapeutic target in melanoma: Immunotoxins targeting Fn14 receptor for malignant melanoma treatment

Zhou, H., Ekmekcioglu, S., Marks, J. W., Mohamedali, K. A., Asrani, K., Phillips, K. K., Brown, S. A. N., Cheng, E., Weiss, M. B., Hittelman, W. N., Tran, N., Yagita, H., Winkles, J. A. & Rosenblum, M. G., Apr 2013, In : Journal of Investigative Dermatology. 133, 4, p. 1052-1062 11 p.

Research output: Contribution to journalArticle

Immunotoxins
Melanoma
Proteins
Tumors
Therapeutics

The use of quantitative proteomics towards biomarker discovery in lung squamous cell carcinoma

Whitsett, T. G., Inge, L. J. & Tran, N., 2013, In : Translational Lung Cancer Research. 2, 6, p. 457-460 4 p.

Research output: Contribution to journalArticle

Proteomics
Squamous Cell Carcinoma
Biomarkers
Lung
Lung Neoplasms
23 Citations (Scopus)

TROY (TNFRSF19) promotes glioblastoma survival signaling and therapeutic resistance

Loftus, J. C., Dhruv, H., Tuncali, S., Kloss, J., Yang, Z., Schumacher, C. A., Cao, B., Williams, B. O., Eschbacher, J. M., Ross, J. T. D. & Tran, N., Aug 2013, In : Molecular Cancer Research. 11, 8, p. 865-874 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Survival
Therapeutics
Astrocytes
Cell Movement
2012
54 Citations (Scopus)

Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells

Fortin, S. P., Ennis, M. J., Schumacher, C. A., Zylstra-Diegel, C. R., Williams, B. O., Ross, J. T. D., Winkles, J. A., Loftus, J. C., Symons, M. H. & Tran, N., Jul 2012, In : Molecular Cancer Research. 10, 7, p. 958-968 11 p.

Research output: Contribution to journalArticle

Guanine Nucleotide Exchange Factors
Glioblastoma
Glioma
Cell Movement
Astrocytes
34 Citations (Scopus)

Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion

Whitsett, T. G., Cheng, E., Inge, L., Asrani, K., Jameson, N. M., Hostetter, G., Weiss, G. J., Kingsley, C. B., Loftus, J. C., Bremner, R., Tran, N. & Winkles, J. A., Jul 2012, In : American Journal of Pathology. 181, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Cell Movement
Protein-Tyrosine Kinases
Neoplasms
47 Citations (Scopus)

MiRNA expression profiling in migrating Glioblastoma cells: Regulation of cell migration and invasion by miR-23b via targeting of Pyk2

Loftus, J. C., Ross, J. T. D., Paquette, K. M., Paulino, V. M., Nasser, S., Yang, Z., Kloss, J., Kim, S., Berens, M. E. & Tran, N., Jun 22 2012, In : PLoS One. 7, 6, e39818.

Research output: Contribution to journalArticle

cell invasion
Glioblastoma
MicroRNAs
cell movement
Glioma
36 Citations (Scopus)

The small GTPase RhoG mediates glioblastoma cell invasion

Kwiatkowska, A., Didier, S., Fortin, S., Chuang, Y., White, T., Berens, M. E., Rushing, E., Eschbacher, J., Tran, N., Chan, A. & Symons, M., Sep 11 2012, In : Molecular Cancer. 11, 65.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Glioblastoma
Epidermal Growth Factor
Cell Survival
Brain
2011
117 Citations (Scopus)

MicroRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration

Arora, S., Ranade, A. R., Tran, N., Nasser, S., Sridhar, S., Korn, R. L., Ross, J. T. D., Dhruv, H., Foss, K. M., Sibenaller, Z., Ryken, T., Gotway, M., Kim, S. & Weiss, G. J., Dec 1 2011, In : International Journal of Cancer. 129, 11, p. 2621-2631 11 p.

Research output: Contribution to journalArticle

MicroRNAs
Non-Small Cell Lung Carcinoma
Brain Neoplasms
Neoplasm Metastasis
Brain
2010
64 Citations (Scopus)

Glycogene expression alterations associated with pancreatic cancer Epithelial-mesenchymal transition in complementary model systems

Maupin, K. A., Sinha, A., Eugster, E., Miller, J., Ross, J., Paulino, V., Keshamouni, V. G., Tran, N., Berens, M., Webb, C. & Haab, B. B., 2010, In : PLoS One. 5, 9, e13002.

Research output: Contribution to journalArticle

Glycosylation
pancreatic neoplasms
Epithelial-Mesenchymal Transition
glycosylation
Pancreatic Neoplasms
101 Citations (Scopus)

Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression

Teo, H., Ghosh, S., Luesch, H., Ghosh, A., Wong, E. T., Malik, N., Orth, A., De Jesus, P., Perry, A. S., Oliver, J. D., Tran, N., Speiser, L. J., Wong, M., Saez, E., Schultz, P., Chanda, S. K., Verma, I. M. & Tergaonkar, V., Aug 2010, In : Nature. 12, 8, p. 758-767 10 p.

Research output: Contribution to journalArticle

Telomere
Breast Neoplasms
Gene Expression
Septic Shock
Mammals
38 Citations (Scopus)

TROY (TNFRSF19) is overexpressed in advanced glial tumors and promotes glioblastoma cell invasion via Pyk2-Rac1 signaling

Paulino, V. M., Yang, Z., Kloss, J., Ennis, M. J., Armstrong, B. A., Loftus, J. C. & Tran, N., Nov 2010, In : Molecular Cancer Research. 8, 11, p. 1558-1567 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Glioma
Neuroglia
Neoplasms
Tumor Necrosis Factors
2009
24 Citations (Scopus)

The Pyk2 FERM domain as a target to inhibit glioma migration

Loftus, J. C., Yang, Z., Tran, N., Kloss, J., Viso, C., Berens, M. E. & Lipinski, C. A., Jun 2009, In : Molecular Cancer Therapeutics. 8, 6, p. 1505-1514 10 p.

Research output: Contribution to journalArticle

Glioma
Phosphorylation
Epitopes
Cell Migration Inhibition
Immunoglobulin Variable Region