• 4780 Citations
  • 40 Scopus h-Index
19952020

Research output per year

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Research Output

1995

Specific attachment and migration of human astrocytoma cells on human but not murine laminin

Giese, A., Rief, M. D., Tran, N. L. & Berens, M. E., Jan 1995, In : Glia. 13, 1, p. 64-74 11 p.

Research output: Contribution to journalArticle

20 Scopus citations

Substrates for astrocytoma invasion

Giese, A., Loo, M. A., Rief, M. D., Tran, N. & Berens, M. E., Aug 1995, In : Neurosurgery. 37, 2, p. 294-302 9 p.

Research output: Contribution to journalArticle

100 Scopus citations
1996

Dichotomy of astrocytoma migration and proliferation

Giese, A., Loo, M. A., Tran, N., Haskett, D., Coons, S. W. & Berens, M. E., Aug 29 1996, In : International Journal of Cancer. 67, 2, p. 275-282 8 p.

Research output: Contribution to journalArticle

255 Scopus citations
1998

Altered gene expression in human astrocytoma cells selected for migration: I. Thromboxane synthase

Mcdonough, W., Tran, N., Giese, A., Norman, S. A. & Berens, M. E., May 1998, In : Journal of Neuropathology and Experimental Neurology. 57, 5, p. 449-455 7 p.

Research output: Contribution to journalArticle

Open Access
51 Scopus citations
1999

N-cadherin expression in human prostate carcinoma cell lines: An epithelial-mesenchymal transformation mediating adhesion with stromal cells

Tran, N. L., Nagle, R. B., Cress, A. E. & Heimark, R. L., Sep 1999, In : American Journal of Pathology. 155, 3, p. 787-798 12 p.

Research output: Contribution to journalArticle

189 Scopus citations
2001

Integrin- and cadherin-mediated induction of the matrix metalloprotease matrilysin in cocultures of malignant oral squamous cell carcinoma cells and dermal fibroblasts

Bair, E. L., Massey, C. P., Tran, N. L., Borchers, A. H., Heimark, R. L., Cress, A. E. & Bowden, G. T., Nov 1 2001, In : Experimental Cell Research. 270, 2, p. 259-267 9 p.

Research output: Contribution to journalArticle

31 Scopus citations
2002

Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase/Akt pathway by homophilic adhesion and actin cytoskeletal organization

Tran, N. L., Adams, D. G., Vaillancourt, R. R. & Heimark, R. L., Sep 6 2002, In : Journal of Biological Chemistry. 277, 36, p. 32905-32914 10 p.

Research output: Contribution to journalArticle

130 Scopus citations
2003

Differential role of proline-rich tyrosine kinase 2 and focal adhesion kinase in determining glioblastoma migration and proliferation

Lipinski, C. A., Tran, N. L., Bay, C., Kloss, J., McDonough, W. S., Beaudry, C., Berens, M. E. & Loftus, J. C., Mar 1 2003, In : Molecular Cancer Research. 1, 5, p. 323-332 10 p.

Research output: Contribution to journalArticle

61 Scopus citations

Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis

Joy, A. M., Beaudry, C. E., Tran, N. L., Ponce, F. A., Holz, D. R., Demuth, T. & Berens, M. E., Nov 1 2003, In : Journal of cell science. 116, 21, p. 4409-4417 9 p.

Research output: Contribution to journalArticle

128 Scopus citations

Representing and reasoning about signal networks: An illustration using NFκB dependent signaling pathways

Baral, C., Chancellor, K., Tran, N. & Tran, N., Jan 1 2003, Proceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003. Institute of Electrical and Electronics Engineers Inc., p. 623-628 6 p. 1227427. (Proceedings of the 2003 IEEE Bioinformatics Conference, CSB 2003).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

The human Fn14 receptor gene is up-regulated in migrating glioma cells in vitro and overexpressed in advanced glial tumors

Tran, N. L., McDonough, W. S., Donohue, P. J., Winkles, J. A., Berens, T. J., Ross, K. R., Hoelzinger, D. B., Beaudry, C., Coons, S. W. & Berens, M. E., Apr 1 2003, In : American Journal of Pathology. 162, 4, p. 1313-1321 9 p.

Research output: Contribution to journalArticle

116 Scopus citations
2004

A knowledge based approach for representing and reasoning about signaling networks

Baral, C., Chancellor, K., Tran, N., Tran, N. L., Joy, A. & Berens, M., Dec 1 2004, In : Bioinformatics. 20, SUPPL. 1, p. i15-i22

Research output: Contribution to journalArticle

54 Scopus citations
20 Scopus citations

Role of synaptojanin 2 in glioma cell migration and invasion

Chuang, Y. Y., Tran, N. L., Rusk, N., Nakada, M., Berens, M. E. & Symons, M., Nov 15 2004, In : Cancer research. 64, 22, p. 8271-8275 5 p.

Research output: Contribution to journalArticle

118 Scopus citations
2005

Cell migration and invasion assays

Valster, A., Tran, N. L., Nakada, M., Berens, M. E., Chan, A. Y. & Symons, M., Oct 1 2005, In : Methods. 37, 2, p. 208-215 8 p.

Research output: Contribution to journalArticle

219 Scopus citations

EphB2/R-ras signaling regulates glioma cell adhesion, growth, and invasion

Nakada, M., Niska, J. A., Tran, N. L., McDonough, W. S. & Berens, M. E., Aug 2005, In : American Journal of Pathology. 167, 2, p. 565-576 12 p.

Research output: Contribution to journalArticle

116 Scopus citations

Regulation of glioma cell migration by serine-phosphorylated P311

McDonough, W. S., Tran, N. L. & Berens, M. E., Sep 2005, In : Neoplasia. 7, 9, p. 862-872 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFκB pathway activation and BCL-XL/BCL-W expression

Tran, N. L., McDonough, W. S., Savitch, B. A., Sawyer, T. F., Winkles, J. A. & Berens, M. E., Feb 4 2005, In : Journal of Biological Chemistry. 280, 5, p. 3483-3492 10 p.

Research output: Contribution to journalArticle

154 Scopus citations

The tyrosine kinase Pyk2 promotes migration and invasion of glioma cells

Lipinski, C. A., Tran, N. L., Menashi, E., Rohl, C., Kloss, J., Bay, R. C., Berens, M. E. & Loftus, J. C., May 2005, In : Neoplasia. 7, 5, p. 435-445 11 p.

Research output: Contribution to journalArticle

102 Scopus citations
2006

Critical role of the FERM domain in Pyk2 stimulated glioma cell migration

Lipinski, C. A., Tran, N. L., Dooley, A., Pang, Y. P., Rohl, C., Kloss, J., Yang, Z., McDonough, W., Craig, D., Berens, M. E. & Loftus, J. C., Oct 27 2006, In : Biochemical and Biophysical Research Communications. 349, 3, p. 939-947 9 p.

Research output: Contribution to journalArticle

20 Scopus citations

Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-κB and correlate with poor patient outcome

Tran, N. L., McDonough, W. S., Savitch, B. A., Fortin, S. P., Winkles, J. A., Symons, M., Nakada, M., Cunliffe, H. E., Hostetter, G., Hoelzinger, D. B., Rennert, J. L., Michaelson, J. S., Burkly, L. C., Lipinski, C. A., Loftus, J. C., Mariani, L. & Berens, M. E., Oct 1 2006, In : Cancer research. 66, 19, p. 9535-9542 8 p.

Research output: Contribution to journalArticle

139 Scopus citations

Molecular pathways triggering glioma cell invasion

Salhia, B., Tran, N. L., Symons, M., Winkles, J. A., Rutka, J. T. & Berens, M. E., Aug 11 2006, In : Expert Review of Molecular Diagnostics. 6, 4, p. 613-626 14 p.

Research output: Contribution to journalReview article

55 Scopus citations

N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1

Alexander, N. R., Tran, N. L., Rekapally, H., Summers, C. E., Glackin, C. & Heimark, R. L., Apr 1 2006, In : Cancer research. 66, 7, p. 3365-3369 5 p.

Research output: Contribution to journalArticle

173 Scopus citations

TWEAK and Fn14: New molecular targets for cancer therapy?

Winkles, J. A., Tran, N. L. & Berens, M. E., Apr 8 2006, In : Cancer Letters. 235, 1, p. 11-17 7 p.

Research output: Contribution to journalShort survey

55 Scopus citations
2007

Identification of Fn14/TWEAK receptor as a potential therapeutic target in esophageal adenocarcinoma

Watts, G. S., Tran, N. L., Berens, M. E., Bhattacharyya, A. K., Nelson, M. A., Montgomery, E. A. & Sampliner, R. E., Nov 15 2007, In : International Journal of Cancer. 121, 10, p. 2132-2139 8 p.

Research output: Contribution to journalArticle

48 Scopus citations

Molecular targets of glioma invasion

Nakada, M., Nakada, S., Demuth, T., Tran, N. L., Hoelzinger, D. B. & Berens, M. E., Feb 1 2007, In : Cellular and Molecular Life Sciences. 64, 4, p. 458-478 21 p.

Research output: Contribution to journalReview article

289 Scopus citations

Role of TWEAK and Fn14 in tumor biology

Winkles, J. A., Tran, N. L., Brown, S. A. N., Stains, N., Cunliffe, H. E. & Berens, M. E., Jan 1 2007, In : Frontiers in Bioscience. 12, 7, p. 2761-2771 11 p.

Research output: Contribution to journalReview article

40 Scopus citations
2008

Extended survival of Pyk2 or FAK deficient orthotopic glioma xenografts

Lipinski, C. A., Tran, N. L., Viso, C., Kloss, J., Yang, Z., Berens, M. E. & Loftus, J. C., Jul 24 2008, In : Journal of neuro-oncology. 90, 2, p. 181-189 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

The fibroblast growth factor-inducible 14 receptor is highly expressed in HER2-positive breast tumors and regulates breast cancer cell invasive capacity

Willis, A. L., Tran, N. L., Chatigny, J. M., Charlton, N., Vu, H., Brown, S. A. N., Black, M. A., McDonough, W. S., Fortin, S. P., Niska, J. R., Winkles, J. A. & Cunliffe, H. E., May 1 2008, In : Molecular Cancer Research. 6, 5, p. 725-734 10 p.

Research output: Contribution to journalArticle

65 Scopus citations

The guanine nucleotide exchange factors Trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma

Salhia, B., Tran, N. L., Chan, A., Wolf, A., Nakada, M., Rutka, F., Ennis, M., McDonough, W. S., Berens, M. E., Symons, M. & Rutka, J. T., Dec 2008, In : American Journal of Pathology. 173, 6, p. 1828-1838 11 p.

Research output: Contribution to journalArticle

129 Scopus citations
2009

The Pyk2 FERM domain as a target to inhibit glioma migration

Loftus, J. C., Yang, Z., Tran, N. L., Kloss, J., Viso, C., Berens, M. E. & Lipinski, C. A., Jun 2009, In : Molecular cancer therapeutics. 8, 6, p. 1505-1514 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Tumor necrosis factor-like weak inducer of apoptosis stimulation of glioma cell survival is dependent on Akt2 function

Fortin, S. P., Ennis, M. J., Savitch, B. A., Carpentieri, D., McDonough, W. S., Winkles, J. A., Loftus, J. C., Kingsley, C., Hostetter, G. & Tran, N. L., Nov 1 2009, In : Molecular Cancer Research. 7, 11, p. 1871-1881 11 p.

Research output: Contribution to journalArticle

43 Scopus citations
2010

Glycogene expression alterations associated with pancreatic cancer Epithelial-mesenchymal transition in complementary model systems

Maupin, K. A., Sinha, A., Eugster, E., Miller, J., Ross, J., Paulino, V., Keshamouni, V. G., Tran, N., Berens, M., Webb, C. & Haab, B. B., 2010, In : PloS one. 5, 9, e13002.

Research output: Contribution to journalArticle

69 Scopus citations

Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression

Teo, H., Ghosh, S., Luesch, H., Ghosh, A., Wong, E. T., Malik, N., Orth, A., De Jesus, P., Perry, A. S., Oliver, J. D., Tran, N. L., Speiser, L. J., Wong, M., Saez, E., Schultz, P., Chanda, S. K., Verma, I. M. & Tergaonkar, V., Aug 1 2010, In : Nature Cell Biology. 12, 8, p. 758-767 10 p.

Research output: Contribution to journalArticle

116 Scopus citations

TROY (TNFRSF19) is overexpressed in advanced glial tumors and promotes glioblastoma cell invasion via Pyk2-Rac1 signaling

Paulino, V. M., Yang, Z., Kloss, J., Ennis, M. J., Armstrong, B. A., Loftus, J. C. & Tran, N. L., Nov 2010, In : Molecular Cancer Research. 8, 11, p. 1558-1567 10 p.

Research output: Contribution to journalArticle

45 Scopus citations
2011

MicroRNA-328 is associated with (non-small) cell lung cancer (NSCLC) brain metastasis and mediates NSCLC migration

Arora, S., Ranade, A. R., Tran, N. L., Nasser, S., Sridhar, S., Korn, R. L., Ross, J. T. D., Dhruv, H., Foss, K. M., Sibenaller, Z., Ryken, T., Gotway, M. B., Kim, S. & Weiss, G. J., Dec 1 2011, In : International Journal of Cancer. 129, 11, p. 2621-2631 11 p.

Research output: Contribution to journalArticle

123 Scopus citations
2012

Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells

Fortin, S. P., Ennis, M. J., Schumacher, C. A., Zylstra-Diegel, C. R., Williams, B. O., Ross, J. T. D., Winkles, J. A., Loftus, J. C., Symons, M. H. & Tran, N. L., Jul 1 2012, In : Molecular Cancer Research. 10, 7, p. 958-968 11 p.

Research output: Contribution to journalArticle

59 Scopus citations

Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion

Whitsett, T. G., Cheng, E., Inge, L., Asrani, K., Jameson, N. M., Hostetter, G., Weiss, G. J., Kingsley, C. B., Loftus, J. C., Bremner, R., Tran, N. L. & Winkles, J. A., Jul 1 2012, In : American Journal of Pathology. 181, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

36 Scopus citations

MiRNA expression profiling in migrating Glioblastoma cells: Regulation of cell migration and invasion by miR-23b via targeting of Pyk2

Loftus, J. C., Ross, J. T. D., Paquette, K. M., Paulino, V. M., Nasser, S., Yang, Z., Kloss, J., Kim, S., Berens, M. E. & Tran, N. L., Jun 22 2012, In : PloS one. 7, 6, e39818.

Research output: Contribution to journalArticle

50 Scopus citations

The small GTPase RhoG mediates glioblastoma cell invasion

Kwiatkowska, A., Didier, S., Fortin, S., Chuang, Y., White, T., Berens, M. E., Rushing, E., Eschbacher, J., Tran, N. L., Chan, A. & Symons, M., Sep 11 2012, In : Molecular cancer. 11, 65.

Research output: Contribution to journalArticle

43 Scopus citations
2013

An integrated approach to identifying clinically relevant targets in pediatric gliomas

McEachron, T. A., Tomboc, P. & Tran, N. L., Jul 1 2013, In : CNS oncology. 2, 4, p. 303-306 4 p.

Research output: Contribution to journalEditorial

1 Scopus citations
6 Scopus citations

Implications of Rho GTPase signaling in glioma cell invasion and tumor progression

Fortin Ensign, S. P., Mathews, I. T., Symons, M. H., Berens, M. E. & Tran, N. L., 2013, In : Frontiers in Oncology. 3 OCT, Article 241.

Research output: Contribution to journalReview article

64 Scopus citations

IRS1 is highly expressed in localized breast tumors and regulates the sensitivity of breast cancer cells to chemotherapy, while IRS2 is highly expressed in invasive breast tumors

Porter, H. A., Perry, A., Kingsley, C., Tran, N. L. & Keegan, A. D., Sep 28 2013, In : Cancer Letters. 338, 2, p. 239-248 10 p.

Research output: Contribution to journalArticle

38 Scopus citations

Molecular determinants of lung cancer metastasis to the central nervous system

Whitsett, T. G., Inge, L. J., Dhruv, H. D., Cheung, P. Y., Weiss, G. J., Bremner, R. M., Winkles, J. A. & Tran, N., 2013, In : Translational Lung Cancer Research. 2, 4, p. 273-283 11 p.

Research output: Contribution to journalReview article

9 Scopus citations

New insights into the functional consequences of ephrin A3 mutations in non-small cell lung cancer

Whitsett, T. G., Loftus, J. C., Winkles, J. A. & Tran, N., 2013, In : Translational Lung Cancer Research. 2, 1, p. 3-5 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Reciprocal Activation of Transcription Factors Underlies the Dichotomy between Proliferation and Invasion of Glioma Cells

Dhruv, H. D., McDonough Winslow, W. S., Armstrong, B., Tuncali, S., Eschbacher, J., Kislin, K., Loftus, J. C., Tran, N. L. & Berens, M. E., Aug 15 2013, In : PloS one. 8, 8, e72134.

Research output: Contribution to journalArticle

31 Scopus citations

Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis

Dhruv, H., Loftus, J. C., Narang, P., Petit, J. L., Fameree, M., Burton, J., Tchegho, G., Chow, D., Yin, H., Al-Abed, Y., Berens, M. E., Tran, N. L. & Meurice, N., Nov 8 2013, In : Journal of Biological Chemistry. 288, 45, p. 32261-32276 16 p.

Research output: Contribution to journalArticle

15 Scopus citations

The HER2- and heregulin b1 (HRG)-inducible TNFR superfamily member Fn14 promotes HRG-driven breast cancer cell migration, invasion, and MMP9 expression

Asrani, K., Keri, R. A., Galisteo, R., Brown, S. A. N., Morgan, S. J., Ghosh, A., Tran, N. L. & Winkles, J. A., Apr 1 2013, In : Molecular Cancer Research. 11, 4, p. 393-404 12 p.

Research output: Contribution to journalArticle

32 Scopus citations
21 Scopus citations