• 4314 Citations
  • 37 Scopus h-Index
19952019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1995 2019

2019

Accurate patient-specific machine learning models of glioblastoma invasion using transfer learning

Hu, L. S., Yoon, H., Eschbacher, J. M., Baxter, L. C., Dueck, A., Nespodzany, A., Smith, K. A., Nakaji, P., Xu, Y., Wang, L., Karis, J. P., Hawkins-Daarud, A. J., Singleton, K. W., Jackson, P. R., Anderies, B. J., Bendok, B., Zimmerman, R. S., Quarles, C., Porter-Umphrey, A. B., Mrugala, M. & 11 others, Sharma, A., Hoxworth, J. M., Sattur, M. G., Sanai, N., Koulemberis, P. E., Krishna, C., Mitchell, J. R., Wu, T., Tran, N., Swanson, K. & Li, J., Jan 1 2019, In : American Journal of Neuroradiology. 40, 3, p. 418-425 8 p.

Research output: Contribution to journalArticle

Open Access
Glioblastoma
Cell Count
Neoplasms
Image-Guided Biopsy
Diffusion Tensor Imaging
18 Citations (Scopus)

Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer

Bryant, K. L., Stalnecker, C. A., Zeitouni, D., Klomp, J. E., Peng, S., Tikunov, A. P., Gunda, V., Pierobon, M., Waters, A. M., George, S. D., Tomar, G., Papke, B., Hobbs, G. A., Yan, L., Hayes, T. K., Diehl, J. N., Goode, G. D., Chaika, N. V., Wang, Y., Zhang, G. F. & 11 others, Witkiewicz, A. K., Knudsen, E. S., Petricoin, E. F., Singh, P. K., Macdonald, J. M., Tran, N., Lyssiotis, C. A., Ying, H., Kimmelman, A. C., Cox, A. D. & Der, C. J., Apr 1 2019, In : Nature Medicine. 25, 4, p. 628-640 13 p.

Research output: Contribution to journalArticle

Autophagy
Chloroquine
Pancreatic Neoplasms
Fluxes
Adenocarcinoma
1 Citation (Scopus)

Germline predisposition and copy number alteration in pre-stage lung adenocarcinomas presenting as ground-glass nodules

Ren, Y., Huang, S., Dai, C., Xie, D., Zheng, L., Xie, H., Zheng, H., She, Y., Zhou, F., Wang, Y., Li, P., Fei, K., Jiang, G., Zhang, Y., Su, B., Alejandro Sweet-Cordero, E., Tran, N., Yang, Y. D., Patel, J. N., Rolfo, C. & 7 others, Rocco, G., Cardona, A. F., Tuzi, A., Suter, M. B., Yang, P., Xu, W. & Chen, C., Jan 1 2019, In : Frontiers in Oncology. 9, MAR, 288.

Research output: Contribution to journalArticle

Open Access
Glass
Germ-Line Mutation
Mutation
Exome
Mutagens

Leveraging spatial variation in tumor purity for improved somatic variant calling of archival tumor only samples

Halperin, R. F., Liang, W. S., Kulkarni, S., Tassone, E. E., Adkins, J., Enriquez, D., Tran, N., Hank, N. C., Newell, J., Kodira, C., Korn, R., Berens, M. E., Kim, S. & Byron, S. A., Jan 1 2019, In : Frontiers in Oncology. 9, MAR

Research output: Contribution to journalArticle

Open Access
Neoplasms
Exome
Translational Medical Research
Glioblastoma
Genomics
2018
4 Citations (Scopus)

A Novel Signaling Complex between TROY and EGFR Mediates Glioblastoma Cell Invasion

Ding, Z., Roos, A., Kloss, J., Dhruv, H., Peng, S., Pirrotte, P., Eschbacher, J. M., Tran, N. & Loftus, J. C., Feb 1 2018, In : Molecular Cancer Research. 16, 2, p. 322-332 11 p.

Research output: Contribution to journalArticle

Glioblastoma
temozolomide
Neoplasms
Epidermal Growth Factor
Survival
1 Citation (Scopus)

Differential expression of the TWEAK receptor Fn14 in IDH1 wild-type and mutant gliomas

Hersh, D. S., Peng, S., Dancy, J. G., Galisteo, R., Eschbacher, J. M., Castellani, R. J., Heath, J. E., Legesse, T., Kim, A. J., Woodworth, G. F., Tran, N. & Winkles, J. A., Feb 16 2018, (Accepted/In press) In : Journal of Neuro-Oncology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Isocitrate Dehydrogenase
Glioma
Glioblastoma
decitabine
TWEAK receptor
1 Citation (Scopus)

EGFRvIII–Stat5 signaling enhances glioblastoma cell migration and survival

Roos, A., Dhruv, H. D., Peng, S., Inge, L. J., Tuncali, S., Pineda, M., Millard, N., Mayo, Z., Eschbacher, J. M., Loftus, J. C., Winkles, J. A. & Tran, N., Jul 1 2018, In : Molecular Cancer Research. 16, 7, p. 1185-1195 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell Movement
Cell Survival
Neoplasms
Pimozide
15 Citations (Scopus)

Evaluation of pre-analytical factors affecting plasma DNA analysis

Markus, H., Contente-Cuomo, T., Farooq, M., Liang, W. S., Borad, M. J., Sivakumar, S., Gollins, S., Tran, N., Dhruv, H. D., Berens, M. E., Bryce, A. H., Sekulic, A. D., Ribas, A., Trent, J. M., Lorusso, P. M. & Murtaza, M., Dec 1 2018, In : Scientific Reports. 8, 1, 7375.

Research output: Contribution to journalArticle

DNA
cells
sampling
droplets
blood
4 Citations (Scopus)

Integrated mapping of pharmacokinetics and pharmacodynamics in a patient-derived xenograft model of glioblastoma

Randall, E. C., Emdal, K. B., Laramy, J. K., Kim, M., Roos, A., Calligaris, D., Regan, M. S., Gupta, S. K., Mladek, A. C., Carlson, B. L., Johnson, A. J., Lu, F. K., Xie, X. S., Joughin, B. A., Reddy, R. J., Peng, S., Abdelmoula, W. M., Jackson, P. R., Kolluri, A., Kellersberger, K. A. & 8 others, Agar, J. N., Lauffenburger, D. A., Swanson, K., Tran, N., Elmquist, W. F., White, F. M., Sarkaria, J. N. & Agar, N. Y. R., Dec 1 2018, In : Nature Communications. 9, 1, 4904.

Research output: Contribution to journalArticle

Pharmacodynamics
Pharmacokinetics
Glioblastoma
Heterografts
drugs

PDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival

Ding, Z., Dhruv, H., Kwiatkowska-Piwowarczyk, A., Ruggieri, R., Kloss, J., Symons, M., Pirrotte, P., Eschbacher, J. M., Tran, N. & Loftus, J. C., Oct 1 2018, In : Neoplasia (United States). 20, 10, p. 1045-1058 14 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
Glioblastoma
Cell Survival
Glioma
Cell Movement
17 Citations (Scopus)

Prospective Feasibility Trial for Genomics-Informed Treatment in Recurrent and Progressive Glioblastoma

Byron, S. A., Tran, N., Halperin, R. F., Phillips, J. J., Kuhn, J. G., De Groot, J. F., Colman, H., Ligon, K. L., Wen, P. Y., Cloughesy, T. F., Mellinghoff, I. K., Butowski, N. A., Taylor, J. W., Clarke, J. L., Chang, S. M., Berger, M. S., Molinaro, A. M., Maggiora, G. M., Peng, S., Nasser, S. & 6 others, Liang, W. S., Trent, J. M., Berens, M. E., Carpten, J. D., Craig, D. W. & Prados, M. D., Jan 15 2018, In : Clinical Cancer Research. 24, 2, p. 295-305 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Genomics
Therapeutics
Exome
RNA Sequence Analysis
1 Citation (Scopus)

The TNF receptor family member Fn14 is highly expressed in recurrent glioblastoma and in GBM patient-derived xenografts with acquired temozolomide resistance

Hersh, D. S., Harder, B. G., Roos, A., Peng, S., Heath, J. E., Legesse, T., Kim, A. J., Woodworth, G. F., Tran, N. & Winkles, J. A., Jan 1 2018, In : Neuro-Oncology. 20, 10, p. 1321-1330 10 p.

Research output: Contribution to journalArticle

temozolomide
Tumor Necrosis Factor Receptors
Glioblastoma
Heterografts
Gliosarcoma
2017
10 Citations (Scopus)

Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells

Roos, A., Dhruv, H. D., Mathews, I. T., Inge, L. J., Tuncali, S., Hartman, L. K., Chow, D., Millard, N., Yin, H. H., Kloss, J., Loftus, J. C., Winkles, J. A., Berens, M. E. & Tran, N., 2017, In : Oncotarget. 8, 7, p. 12234-12246 13 p.

Research output: Contribution to journalArticle

Aurintricarboxylic Acid
Glioblastoma
Glioma
temozolomide
Cell Survival
6 Citations (Scopus)

Integrated genomic analysis of survival outliers in glioblastoma

Peng, S., Dhruv, H., Armstrong, B., Salhia, B., Legendre, C., Kiefer, J., Parks, J., Virk, S., Sloan, A. E., Ostrom, Q. T., Barnholtz-Sloan, J. S., Tran, N. & Berens, M. E., 2017, In : Neuro-Oncology. 19, 6, p. 833-844 12 p.

Research output: Contribution to journalArticle

Glioblastoma
Survival Analysis
Mitogen-Activated Protein Kinase 1
temozolomide
Methylation
32 Citations (Scopus)

Molecular and microenvironmental determinants of glioma stem-like cell survival and invasion

Roos, A., Ding, Z., Loftus, J. C. & Tran, N., Jun 16 2017, In : Frontiers in Oncology. 7, JUN, 120.

Research output: Contribution to journalReview article

Glioma
Cell Survival
Stem Cells
Glioblastoma
Cues
1 Citation (Scopus)

MTCTScan: A comprehensive platform for annotation and prioritization of mutations affecting drug sensitivity in cancers

Li, M. J., Yao, H., Huang, D., Liu, H., Liu, Z., Xu, H., Qin, Y., Prinz, J., Xia, W., Wang, P., Yan, B., Tran, N., Kocher, J-P., Sham, P. C. & Wang, J., Jul 3 2017, In : Nucleic Acids Research. 45, W1, p. W215-W221

Research output: Contribution to journalArticle

Mutation
Pharmaceutical Preparations
Neoplasms
Therapeutics
Precision Medicine
44 Citations (Scopus)

Radiogenomics to characterize regional genetic heterogeneity in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Baxter, L. C., Gaw, N., Ranjbar, S., Plasencia, J., Dueck, A., Peng, S., Smith, K. A., Nakaji, P., Karis, J. P., Quarles, C. C., Wu, T., Loftus, J. C., Jenkins, R. B., Sicotte, H., Kollmeyer, T. M., O'Neill, B. P., Elmquist, W. & 7 others, Hoxworth, J. M., Frakes, D., Sarkaria, J. N., Swanson, K., Tran, N., Li, J. & Mitchell, J. R., 2017, In : Neuro-Oncology. 19, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Glioblastoma
erbB-1 Genes
Neoplasms
Biopsy
19 Citations (Scopus)

RNA sequencing and transcriptome arrays analyses show opposing results for alternative splicing in patient derived samples

Nazarov, P. V., Muller, A., Kaoma, T., Nicot, N., Maximo, C., Birembaut, P., Tran, N., Dittmar, G. & Vallar, L., Jun 6 2017, In : BMC Genomics. 18, 1, 443.

Research output: Contribution to journalArticle

RNA Sequence Analysis
Alternative Splicing
Gene Expression Profiling
Long Noncoding RNA
Exons
2016
4 Citations (Scopus)

Pharmacological Inhibition of the Protein Kinase MRK/ZAK Radiosensitizes Medulloblastoma

Markowitz, D., Powell, C., Tran, N., Berens, M. E., Ryken, T. C., Vanan, M., Rosen, L., He, M., Sun, S., Symons, M., Al-Abed, Y. & Ruggieri, R., Aug 1 2016, In : Molecular Cancer Therapeutics. 15, 8, p. 1799-1808 10 p.

Research output: Contribution to journalArticle

Medulloblastoma
Protein Kinases
Pharmacology
Radiation
Cell Cycle Checkpoints
5 Citations (Scopus)

Propentofylline inhibits glioblastoma cell invasion and survival by targeting the TROY signaling pathway

Dhruv, H. D., Roos, A., Tomboc, P. J., Tuncali, S., Chavez, A., Mathews, I., Berens, M. E., Loftus, J. C. & Tran, N., Feb 1 2016, In : Journal of Neuro-Oncology. 126, 3, p. 397-404 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell Survival
temozolomide
Glioma
Alzheimer Disease
9 Citations (Scopus)

SGEF is regulated via TWEAK/Fn14/NF-κB signaling and promotes survival by modulation of the DNA repair response to temozolomide

Fortin Ensign, S. P., Roos, A., Mathews, I. T., Dhruv, H. D., Tuncali, S., Sarkaria, J. N., Symons, M. H., Loftus, J. C., Berens, M. E. & Tran, N., Mar 1 2016, In : Molecular Cancer Research. 14, 3, p. 302-312 11 p.

Research output: Contribution to journalArticle

temozolomide
DNA Repair
Glioblastoma
Glioma
Therapeutics
24 Citations (Scopus)

The TWEAK receptor Fn14 is a potential cell surface portal for targeted delivery of glioblastoma therapeutics

Perez, J. G., Tran, N., Rosenblum, M. G., Schneider, C. S., Connolly, N. P., Kim, A. J., Woodworth, G. F. & Winkles, J. A., Apr 28 2016, In : Oncogene. 35, 17, p. 2145-2155 11 p.

Research output: Contribution to journalReview article

Glioblastoma
Glioma
Brain
Neoplasms
Brain Neoplasms
13 Citations (Scopus)

Tumor-targeted nanotherapeutics: Overcoming treatment barriers for glioblastoma

Wadajkar, A. S., Dancy, J. G., Hersh, D. S., Anastasiadis, P., Tran, N., Woodworth, G. F., Winkles, J. A. & Kim, A. J., 2016, (Accepted/In press) In : Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology.

Research output: Contribution to journalArticle

Glioblastoma
Epidermal Growth Factor Receptor
Tumors
Interleukin-13 Receptors
Proteins
2015
34 Citations (Scopus)

Multi-parametric MRI and texture analysis to visualize spatial histologic heterogeneity and tumor extent in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Gaw, N., Dueck, A., Smith, K. A., Nakaji, P., Plasencia, J., Ranjbar, S., Price, S. J., Tran, N., Loftus, J. C., Jenkins, R. B., O'Neill, B. P., Elmquist, W., Baxter, L. C., Gao, F., Frakes, D., Karis, J. P., Zwart, C. & 5 others, Swanson, K., Sarkaria, J. N., Wu, T., Mitchell, J. R. & Li, J., Nov 1 2015, In : PLoS One. 10, 11, e0141506.

Research output: Contribution to journalArticle

Glioblastoma
Magnetic resonance imaging
Tumors
Textures
texture
58 Citations (Scopus)

Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein

Salanti, A., Clausen, T. M., Agerbæk, M. O., Al Nakouzi, N., Dahlbäck, M., Oo, H. Z., Lee, S., Gustavsson, T., Rich, J. R., Hedberg, B. J., Mao, Y., Barington, L., Pereira, M. A., LoBello, J., Endo, M., Fazli, L., Soden, J., Wang, C. K., Sander, A. F., Dagil, R. & 15 others, Thrane, S., Holst, P. J., Meng, L., Favero, F., Weiss, G. J., Nielsen, M. A., Freeth, J., Nielsen, T. O., Zaia, J., Tran, N., Trent, J., Babcook, J. S., Theander, T. G., Sorensen, P. H. & Daugaard, M., Oct 12 2015, In : Cancer Cell. 28, 4, p. 500-514 15 p., 2143.

Research output: Contribution to journalArticle

Glycosaminoglycans
Malaria
Carrier Proteins
Chondroitin Sulfates
Neoplasms
11 Citations (Scopus)

The TWEAK receptor Fn14 is an Src-inducible protein and a positive regulator of Src-driven cell invasion

Cheng, E., Whitsett, T. G., Tran, N. & Winkles, J. A., Mar 1 2015, In : Molecular Cancer Research. 13, 3, p. 575-583 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
src-Family Kinases
Proteins
Gene Expression
Neoplasms
86 Citations (Scopus)

Toward precision medicine in glioblastoma: The promise and the challenges

Prados, M. D., Byron, S. A., Tran, N., Phillips, J. J., Molinaro, A. M., Ligon, K. L., Wen, P. Y., Kuhn, J. G., Mellinghoff, I. K., De Groot, J. F., Colman, H., Cloughesy, T. F., Chang, S. M., Ryken, T. C., Tembe, W. D., Kiefer, J. A., Berens, M. E., Craig, D. W., Carpten, J. D. & Trent, J. M., 2015, In : Neuro-Oncology. 17, 8, p. 1051-1063 13 p.

Research output: Contribution to journalReview article

Precision Medicine
Glioblastoma
Neoplasms
Central Nervous System
Pharmacokinetics
2014
108 Citations (Scopus)

Current approaches to the treatment of metastatic brain tumours

Owonikoko, T. K., Arbiser, J., Zelnak, A., Shu, H. K. G., Shim, H., Robin, A. M., Kalkanis, S. N., Whitsett, T. G., Salhia, B., Tran, N., Ryken, T., Moore, M. K., Egan, K. M. & Olson, J. J., Apr 25 2014, In : Nature Reviews Clinical Oncology. 11, 4, p. 203-222 20 p.

Research output: Contribution to journalReview article

Brain Neoplasms
Molecular Biology
Brain
Radiotherapy
Radiation
9 Citations (Scopus)

Development of human serine protease-based therapeutics targeting Fn14 and identification of Fn14 as a new target overexpressed in TNBC

Zhou, H., Mohamedali, K. A., Gonzalez-Angulo, A. M., Cao, Y., Migliorini, M., Cheung, L. H., LoBello, J., Lei, X., Qi, Y., Hittelman, W. N., Winkles, J. A., Tran, N. & Rosenblum, M. G., Nov 1 2014, In : Molecular Cancer Therapeutics. 13, 11, p. 2688-2705 18 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Granzymes
Human Development
Serine Proteases
Neoplasms
13 Citations (Scopus)

FN14 expression correlates with MET in NSCLC and promotes MET-driven cell invasion

Whitsett, T. G., Fortin Ensign, S. P., Dhruv, H. D., Inge, L. J., Kurywchak, P., Wolf, K. K., LoBello, J., Kingsley, C. B., Allen, J. W., Weiss, G. J. & Tran, N., 2014, In : Clinical and Experimental Metastasis. 31, 6, p. 613-623 11 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Neoplasms
Proteins
Neoplasm Metastasis
Cell Movement
13 Citations (Scopus)

Guanine nucleotide exchange factor Dock7 mediates HGF-induced glioblastoma cell invasion via Rac activation

Murray, D. W., Didier, S., Chan, A., Paulino, V., Van Aelst, L., Ruggieri, R., Tran, N., Byrne, A. T. & Symons, M., Mar 4 2014, In : British Journal of Cancer. 110, 5, p. 1307-1315 9 p.

Research output: Contribution to journalArticle

Guanine Nucleotide Exchange Factors
Glioblastoma
lissamine rhodamine B
GTP Phosphohydrolase Activators
rho GTP-Binding Proteins
53 Citations (Scopus)

Integrated genomic and epigenomic analysis of breast cancer brain metastasis

Salhia, B., Kiefer, J., Ross, J. T. D., Metapally, R., Martinez, R. A., Johnson, K. N., DiPerna, D. M., Paquette, K. M., Jung, S., Nasser, S., Wallstrom, G., Tembe, W., Baker, A., Carpten, J., Resau, J., Ryken, T., Sibenaller, Z., Petricoin, E. F., Liotta, L. A., Ramanathan, R. K. & 2 others, Berens, M. E. & Tran, N., Jan 29 2014, In : PLoS One. 9, 1, e85448.

Research output: Contribution to journalArticle

Epigenomics
epigenetics
Brain Neoplasms
metastasis
breast neoplasms
10 Citations (Scopus)

LKB1 inactivation sensitizes non-small cell lung cancer to pharmacological aggravation of ER stress

Inge, L. J., Friel, J. M., Richer, A. L., Fowler, A. J., Whitsett, T., Smith, M. A., Tran, N. & Bremner, R. M., Oct 1 2014, In : Cancer Letters. 352, 2, p. 187-195 9 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Pharmacology
Deoxyglucose
Brefeldin A
Therapeutics
15 Citations (Scopus)

Mcl-1 mediates TWEAK/Fn14-induced non-small cell lung cancer survival and therapeutic response

Whitsett, T. G., Mathews, I. T., Cardone, M. H., Lena, R. J., Pierceall, W. E., Bittner, M., Sima, C., LoBello, J., Weiss, G. J. & Tran, N., 2014, In : Molecular Cancer Research. 12, 4, p. 550-559 10 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Survival
Cell Survival
Therapeutics
Neoplasms
1 Citation (Scopus)

Rho GTPases and their activators, guanine nucleotide exchange factors (GEFs): Their roles in glioma cell invasion

Hu, B., Symons, M., Salhia, B., Fortin, S. P., Tran, N., Rutka, J. & Cheng, S. Y., Jan 1 2014, Signaling Pathways and Molecular Mediators in Metastasis. Springer Netherlands, p. 143-169 27 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

GTP Phosphohydrolase Activators
Guanine Nucleotide Exchange Factors
rho GTP-Binding Proteins
Glioblastoma
Glioma
8 Citations (Scopus)

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioblastoma cell chemotaxis via Lyn activation

Dhruv, H. D., Whitsett, T. G., Jameson, N. M., Patel, F., Winkles, J. A., Berens, M. E. & Tran, N., Jan 2014, In : Carcinogenesis. 35, 1, p. 218-226 9 p.

Research output: Contribution to journalArticle

Chemotaxis
Glioblastoma
Glioma
src-Family Kinases
Tumor Necrosis Factor-alpha
2013
1 Citation (Scopus)

An integrated approach to identifying clinically relevant targets in pediatric gliomas

McEachron, T. A., Tomboc, P. & Tran, N., Jul 1 2013, In : CNS oncology. 2, 4, p. 303-306 4 p.

Research output: Contribution to journalEditorial

Neurosurgery
Brain Neoplasms
Glioma
Radiotherapy
Pediatrics
6 Citations (Scopus)
Barrett Esophagus
src-Family Kinases
Apoptosis
Cell Line
Growth
54 Citations (Scopus)

Implications of Rho GTPase signaling in glioma cell invasion and tumor progression

Fortin Ensign, S. P., Mathews, I. T., Symons, M. H., Berens, M. E. & Tran, N., 2013, In : Frontiers in Oncology. 3 OCT, Article 241.

Research output: Contribution to journalReview article

rho GTP-Binding Proteins
Glioblastoma
Glioma
Neoplasms
Actin Cytoskeleton
35 Citations (Scopus)

IRS1 is highly expressed in localized breast tumors and regulates the sensitivity of breast cancer cells to chemotherapy, while IRS2 is highly expressed in invasive breast tumors

Porter, H. A., Perry, A., Kingsley, C., Tran, N. & Keegan, A. D., Sep 28 2013, In : Cancer Letters. 338, 2, p. 239-248 10 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Drug Therapy
Carcinoma, Intraductal, Noninfiltrating
MCF-7 Cells
Tyrosine
9 Citations (Scopus)

Molecular determinants of lung cancer metastasis to the central nervous system

Whitsett, T. G., Inge, L. J., Dhruv, H. D., Cheung, P. Y., Weiss, G. J., Bremner, R. M., Winkles, J. A. & Tran, N., 2013, In : Translational Lung Cancer Research. 2, 4, p. 273-283 11 p.

Research output: Contribution to journalReview article

Lung Neoplasms
Central Nervous System
Neoplasm Metastasis
Lung
Mortality
1 Citation (Scopus)

New insights into the functional consequences of ephrin A3 mutations in non-small cell lung cancer

Whitsett, T. G., Loftus, J. C., Winkles, J. A. & Tran, N., 2013, In : Translational Lung Cancer Research. 2, 1, p. 3-5 3 p.

Research output: Contribution to journalArticle

Ephrin-A3
Non-Small Cell Lung Carcinoma
Mutation
27 Citations (Scopus)

Reciprocal Activation of Transcription Factors Underlies the Dichotomy between Proliferation and Invasion of Glioma Cells

Dhruv, H. D., McDonough Winslow, W. S., Armstrong, B., Tuncali, S., Eschbacher, J., Kislin, K., Loftus, J. C., Tran, N. & Berens, M. E., Aug 15 2013, In : PLoS One. 8, 8, e72134.

Research output: Contribution to journalArticle

Glioma
Transcription Factors
transcription factors
Chemical activation
Cells
15 Citations (Scopus)

Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis

Dhruv, H., Loftus, J. C., Narang, P., Petit, J. L., Fameree, M., Burton, J., Tchegho, G., Chow, D., Yin, H., Al-Abed, Y., Berens, M. E., Tran, N. & Meurice, N., Nov 8 2013, In : Journal of Biological Chemistry. 288, 45, p. 32261-32276 16 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Tumor Necrosis Factor-alpha
Apoptosis
Small Molecule Libraries
Molecules
32 Citations (Scopus)

The HER2- and heregulin b1 (HRG)-inducible TNFR superfamily member Fn14 promotes HRG-driven breast cancer cell migration, invasion, and MMP9 expression

Asrani, K., Keri, R. A., Galisteo, R., Brown, S. A. N., Morgan, S. J., Ghosh, A., Tran, N. & Winkles, J. A., Apr 2013, In : Molecular Cancer Research. 11, 4, p. 393-404 12 p.

Research output: Contribution to journalArticle

Neuregulin-1
Cell Movement
Breast Neoplasms
MCF-7 Cells
erbB-2 Genes
20 Citations (Scopus)
TNF Receptor-Associated Factor 2
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Guanine Nucleotide Exchange Factors
src Homology Domains
Fibroblast Growth Factors
32 Citations (Scopus)

The TWEAK receptor Fn14 is a therapeutic target in melanoma: Immunotoxins targeting Fn14 receptor for malignant melanoma treatment

Zhou, H., Ekmekcioglu, S., Marks, J. W., Mohamedali, K. A., Asrani, K., Phillips, K. K., Brown, S. A. N., Cheng, E., Weiss, M. B., Hittelman, W. N., Tran, N., Yagita, H., Winkles, J. A. & Rosenblum, M. G., Apr 2013, In : Journal of Investigative Dermatology. 133, 4, p. 1052-1062 11 p.

Research output: Contribution to journalArticle

Immunotoxins
Melanoma
Proteins
Tumors
Therapeutics

The use of quantitative proteomics towards biomarker discovery in lung squamous cell carcinoma

Whitsett, T. G., Inge, L. J. & Tran, N., 2013, In : Translational Lung Cancer Research. 2, 6, p. 457-460 4 p.

Research output: Contribution to journalArticle

Proteomics
Squamous Cell Carcinoma
Biomarkers
Lung
Lung Neoplasms
23 Citations (Scopus)

TROY (TNFRSF19) promotes glioblastoma survival signaling and therapeutic resistance

Loftus, J. C., Dhruv, H., Tuncali, S., Kloss, J., Yang, Z., Schumacher, C. A., Cao, B., Williams, B. O., Eschbacher, J. M., Ross, J. T. D. & Tran, N., Aug 2013, In : Molecular Cancer Research. 11, 8, p. 865-874 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Survival
Therapeutics
Astrocytes
Cell Movement
2012
54 Citations (Scopus)

Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells

Fortin, S. P., Ennis, M. J., Schumacher, C. A., Zylstra-Diegel, C. R., Williams, B. O., Ross, J. T. D., Winkles, J. A., Loftus, J. C., Symons, M. H. & Tran, N., Jul 2012, In : Molecular Cancer Research. 10, 7, p. 958-968 11 p.

Research output: Contribution to journalArticle

Guanine Nucleotide Exchange Factors
Glioblastoma
Glioma
Cell Movement
Astrocytes