Neil Elliot Kay, MD

  • 18978 Citations
  • 74 Scopus h-Index
1973 …2020
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Research Output 1973 2019

2019
14 Citations (Scopus)

GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts

Sterner, R. M., Sakemura, R., Cox, M. J., Yang, N., Khadka, R. H., Forsman, C. L., Hansen, M. J., Jin, F., Ayasoufi, K., Hefazi, M., Schick, K. J., Walters, D. K., Ahmed, O., Chappell, D., Sahmoud, T., Durrant, C., Nevala, W. K., Patnaik, M. M., Pease, L. R., Hedin, K. E. & 3 others, Kay, N. E., Johnson, A. J. & Kenderian, S., Feb 14 2019, In : Blood. 133, 7, p. 697-709 13 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Colony-Stimulating Factor
T-Cell Antigen Receptor
Heterografts
Cytokines
Cell- and Tissue-Based Therapy

IGH translocations in chronic lymphocytic leukemia: Clinicopathologic features and clinical outcomes

Fang, H., Reichard, K. K., Rabe, K. G., Hanson, C. A., Call, T. G., Ding, W. D., Kenderian, S., Muchtar, E., Schwager, S. M., Leis, J. F., Chanan Khan, A. A., Slager, S. L., Braggio, E. D., Smoley, S. A., Kay, N. E., Shanafelt, T. D., Van Dyke, D. L. & Parikh, S. A., Jan 1 2019, (Accepted/In press) In : American Journal of Hematology.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Survival
Therapeutics
Databases

KRAS, NRAS, and BRAF mutations are highly enriched in trisomy 12 chronic lymphocytic leukemia and are associated with shorter treatment-free survival

Vendramini, E., Bomben, R., Pozzo, F., Benedetti, D., Bittolo, T., Rossi, F. M., Dal Bo, M., Rabe, K. G., Pozzato, G., Zaja, F., Chiarenza, A., Di Raimondo, F., Braggio, E. D., Parikh, S. A., Kay, N. E., Shanafelt, T. D., Del Poeta, G., Gattei, V. & Zucchetto, A., Jan 1 2019, In : Leukemia.

Research output: Contribution to journalLetter

Open Access
Trisomy
B-Cell Chronic Lymphocytic Leukemia
Mutation
1 Citation (Scopus)

Rapid disease progression following discontinuation of ibrutinib in patients with chronic lymphocytic leukemia treated in routine clinical practice

Hampel, P. J., Ding, W. D., Call, T. G., Rabe, K. G., Kenderian, S., Witzig, T. E., Muchtar, E., Leis, J. F., Chanan Khan, A. A., Koehler, A. B., Fonder, A. L., Schwager, S. M., Slager, S. L., Shanafelt, T. D., Kay, N. E. & Parikh, S. A., Jan 1 2019, In : Leukemia and Lymphoma.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Disease Progression
Clinical Trials
PCI 32765
Therapeutics
1 Citation (Scopus)

Role of long non-coding RNAs in disease progression of early stage unmutated chronic lymphocytic leukemia

Tschumper, R. C., Shanafelt, T. D., Kay, N. E. & Jelinek, D. F., Jan 1 2019, In : Oncotarget. 10, 1, p. 60-75 16 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
B-Cell Chronic Lymphocytic Leukemia
Disease Progression
Immunoglobulin Heavy Chains
Biological Phenomena
2018
4 Citations (Scopus)

Analytical Considerations in Nanoscale Flow Cytometry of Extracellular Vesicles to Achieve Data Linearity

Gomes, J., Lucien, F., Cooper, T. T., Kim, Y., Williams, K. C., Liao, X., Kaufman, L., Lagugné-Labarthet, F., Kenyon, O., Boysen, J., Kay, N. E., McIntyre, C. W. & Leong, H. S., Jan 1 2018, In : Thrombosis and Haemostasis. 118, 9, p. 1612-1624 13 p.

Research output: Contribution to journalArticle

Flow Cytometry
Blood Platelets
Calibration
Leukemia
Androgens
2 Citations (Scopus)

Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis

Kleinstern, G., Camp, N. J., Goldin, L. R., Vachon, C. M., Vajdic, C. M., De Sanjose, S., Weinberg, J. B., Benavente, Y., Casabonne, D., Liebow, M., Nieters, A., Hjalgrim, H., Melbye, M., Glimelius, B., Adami, H. O., Boffetta, P., Brennan, P., Maynadie, M., McKay, J., Cocco, P. L. & 28 others, Shanafelt, T. D., Call, T. G., Norman, A. D., Hanson, C., Robinson, D., Chaffee, K. G., Brooks-Wilson, A. R., Monnereau, A., Clavel, J., Glenn, M., Curtin, K., Conde, L., Bracci, P. M., Morton, L. M., Cozen, W., Severson, R. K., Chanock, S. J., Spinelli, J. J., Johnston, J. B., Rothman, N., Skibola, C. F., Leis, J. F., Kay, N. E., Smedby, K. E., Berndt, S. I., Cerhan, J. R., Caporaso, N. & Slager, S. L., Jun 7 2018, In : Blood. 131, 23, p. 2541-2551 11 p.

Research output: Contribution to journalArticle

Lymphocytosis
B-Cell Chronic Lymphocytic Leukemia
Cells
Odds Ratio
Single Nucleotide Polymorphism
3 Citations (Scopus)

Autoimmune cytopenias in patients with chronic lymphocytic leukaemia treated with ibrutinib in routine clinical practice at an academic medical centre

Hampel, P. J., Larson, M. C., Kabat, B., Call, T. G., Ding, W. D., Kenderian, S., Bowen, D., Boysen, J., Schwager, S. M., Leis, J. F., Chanan Khan, A. A., Muchtar, E., Hanson, C. A., Slager, S. L., Kay, N. E., Chaffee, K. G., Shanafelt, T. D. & Parikh, S. A., Jan 1 2018, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Therapeutics
PCI 32765
Natural History
Disease-Free Survival

Bone marrow hematopoietic dysfunction in untreated chronic lymphocytic leukemia patients

Manso, B. A., Zhang, H., Mikkelson, M. G., Gwin, K. A., Secreto, C. R., Ding, W. D., Parikh, S. A., Kay, N. E. & Medina, K. L., Jan 1 2018, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Bone Marrow
Hematopoietic Stem Cells
Stem Cells
Colony-Forming Units Assay

Chronic lymphocytic leukemia

Johnston, J. B., Parikh, S. A., Gibson, S. B., Kenderian, S. & Kay, N. E., Nov 19 2018, Wintrobe's Clinical Hematology: Fourteenth Edition. Wolters Kluwer Health Pharma Solutions (Europe) Ltd, p. 5878-5995 118 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

B-Cell Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia cells from ibrutinib treated patients are sensitive to Axl receptor tyrosine kinase inhibitor therapy

Sinha, S., Boysen, J. C., Chaffee, K. G., Kabat, B. F., Slager, S. L., Parikh, S. A., Secreto, C. R., Call, T., Shanafelt, T. D., Leis, J. F., Warner, S. L., Bearss, D. J., Ghosh, A. K. & Kay, N. E., Dec 1 2018, In : Oncotarget. 9, 98, p. 37173-37184 12 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Therapeutics
PCI 32765
axl receptor tyrosine kinase
5 Citations (Scopus)

Chronic lymphocytic leukemia international prognostic index: A systematic review and meta-analysis

Molica, S., Giannarelli, D., Mirabelli, R., Levato, L., Kay, N. E. & Shanafelt, T. D., Jan 18 2018, In : Blood. 131, 3, p. 365-368 4 p.

Research output: Contribution to journalLetter

B-Cell Chronic Lymphocytic Leukemia
Meta-Analysis
5 Citations (Scopus)

Cumulative experience and long term follow-up of pentostatin-based chemoimmunotherapy trials for patients with chronic lymphocytic leukemia

Kay, N. E., LaPlant, B. R., Pettinger, A. M., Call, T. G., Leis, J. F., Ding, W. D., Parikh, S. A., Conte, M. J., Bowen, D. A. & Shanafelt, T. D., Feb 26 2018, (Accepted/In press) In : Expert Review of Hematology. p. 1-13 13 p.

Research output: Contribution to journalArticle

Pentostatin
B-Cell Chronic Lymphocytic Leukemia
Survival
Cyclophosphamide
Research Design
1 Citation (Scopus)

Immune-mediated hemolytic anemia and thrombocytopenia in clonal b-cell disorders: A review

Durani, U., Go, R. S. & Kay, N. E., Oct 1 2018, In : Clinical Advances in Hematology and Oncology. 16, 10, p. 670-676 7 p.

Research output: Contribution to journalReview article

Autoimmune Hemolytic Anemia
Hemolytic Anemia
Thrombocytopenia
Purpura
Idiopathic Thrombocytopenic Purpura
2 Citations (Scopus)

Improvement in Parameters of Hematologic and Immunologic Function and Patient Well-being in the Phase III RESONATE Study of Ibrutinib Versus Ofatumumab in Patients With Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Barrientos, J. C., O'Brien, S., Brown, J. R., Kay, N. E., Reddy, N. M., Coutre, S., Tam, C., Mulligan, S., Jaeger, U., Devereux, S., Pocock, C., Robak, T., Schuster, S. J., Schuh, A., Gill, D., Bloor, A., Dearden, C., Moreno, C., Cull, G., Hamblin, M. & 8 others, Jones, J. A., Eckert, K., Solman, I. G., Suzuki, S., Hsu, E., James, D. F., Byrd, J. C. & Hillmen, P., Jan 1 2018, (Accepted/In press) In : Clinical Lymphoma, Myeloma and Leukemia.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Quality of Life
Survival
PCI 32765
ofatumumab
3 Citations (Scopus)

Outcomes of a large cohort of individuals with clinically ascertained high-count monoclonal B-cell lymphocytosis

Parikh, S. A., Chaffee, K. G., Larson, M. C., Hampel, P. J., Call, T. G., Ding, W. D., Kenderian, S., Leis, J. F., Chanan Khan, A. A., Conte, M. J., Bowen, D., Schwager, S. M., Slager, S. L., Hanson, C. A., Kay, N. E. & Shanafelt, T. D., Jun 3 2018, In : Haematologica. 103, 6, p. e237-e240

Research output: Contribution to journalLetter

Lymphocytosis
B-Lymphocytes

Predictive value of the CLL-IPI in CLL patients receiving chemo-immunotherapy as first-line treatment

Gentile, M., Shanafelt, T. D., Mauro, F. R., Reda, G., Rossi, D., Laurenti, L., Del Principe, M. I., Cutrona, G., Angeletti, I., Coscia, M., Herishanu, Y., Chiarenza, A., Molica, S., Ciolli, S., Goldschmidt, N., Angrilli, F., Giordano, A., Rago, A., Bairey, O., Tripepi, G. & 17 others, Chaffee, K. G., Parikh, S. A., Vigna, E., Zirlik, K., Shvidel, L., Innocenti, I., Recchia, A. G., Di Raimondo, F., Del Poeta, G., Cortelezzi, A., Neri, A., Ferrarini, M., Gaidano, G., Kay, N. E., Polliack, A., Foà, R. & Morabito, F., Nov 1 2018, In : European Journal of Haematology. 101, 5, p. 703-706 4 p.

Research output: Contribution to journalLetter

Immunotherapy
Therapeutics
2 Citations (Scopus)

Prognostic Testing Patterns and Outcomes of Chronic Lymphocytic Leukemia Patients Stratified by Fluorescence In Situ Hybridization/Cytogenetics: A Real-world Clinical Experience in the Connect CLL Registry

Mato, A., Nabhan, C., Kay, N. E., Lamanna, N., Kipps, T. J., Grinblatt, D. L., Flowers, C. R., Farber, C. M., Davids, M. S., Kiselev, P., Swern, A. S., Bhushan, S., Sullivan, K., Flick, E. D. & Sharman, J. P., Feb 1 2018, In : Clinical Lymphoma, Myeloma and Leukemia. 18, 2, p. 114-124.e2

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Fluorescence In Situ Hybridization
Cytogenetics
Registries
Genetic Testing

Reasons for initiation of treatment and predictors of response for patients with Rai stage 0/1 chronic lymphocytic leukemia (CLL) receiving first-line therapy: an analysis of the Connect® CLL cohort study

Flowers, C. R., Nabhan, C., Kay, N. E., Mato, A., Lamanna, N., Farber, C. M., Davids, M. S., Kiselev, P., Swern, A. S., Sullivan, K., Flick, E. D. & Sharman, J. P., Feb 9 2018, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-9 9 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Cohort Studies
Lymphocytosis
Therapeutics
Registries
2017
7 Citations (Scopus)

Akt inhibitor MK-2206 in combination with bendamustine and rituximab in relapsed or refractory chronic lymphocytic leukemia: Results from the N1087 alliance study

Larsen, J. T., Shanafelt, T. D., Leis, J. F., Laplant, B., Call, T., Pettinger, A., Hanson, C., Erlichman, C., Habermann, T. M., Reeder, C., Nikcevich, D., Bowen, D., Conte, M., Boysen, J., Secreto, C., Lesnick, C., Tschumper, R., Jelinek, D. F., Kay, N. E. & Ding, W. D., 2017, (Accepted/In press) In : American Journal of Hematology.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Maximum Tolerated Dose
Safety
Febrile Neutropenia
Exanthema
5 Citations (Scopus)

CD49d associates with nodal presentation and subsequent development of lymphadenopathy in patients with chronic lymphocytic leukaemia

Strati, P., Parikh, S. A., Chaffee, K. G., Achenbach, S. J., Slager, S. L., Call, T. G., Ding, W. D., Jelinek, D. F., Hanson, C. A., Kay, N. E. & Shanafelt, T. D., 2017, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Confidence Intervals
Fluorescence In Situ Hybridization
Lymphoid Leukemia
Cell Adhesion
7 Citations (Scopus)

Chemoimmunotherapy is not dead yet in chronic lymphocytic leukemia

Brown, J. R. & Kay, N. E., Sep 10 2017, In : Journal of Clinical Oncology. 35, 26, p. 2989-2992 4 p.

Research output: Contribution to journalComment/debate

B-Cell Chronic Lymphocytic Leukemia
13 Citations (Scopus)
cohort analysis
disease incidence
Molecular Epidemiology
epidemiology
research program
2 Citations (Scopus)

High prevalence of monoclonal gammopathy among patients with warm autoimmune hemolytic anemia

Ravindran, A., Sankaran, J., Jacob, E. K., Kreuter, J. D., Hook, C. C., Gertz, M., Call, T. G., Pruthi, R. K., Litzow, M. R., Wolanskyj, A. P., Hogan, W., Ashrani, A. A., Begna, K., Marshall, A. L., Kyle, R. A., Kay, N. E. & Go, R. S., 2017, (Accepted/In press) In : American Journal of Hematology.

Research output: Contribution to journalArticle

31 Citations (Scopus)

How I treat autoimmune hemolytic anemia

Go, R. S., Winters, J. L. & Kay, N. E., Jun 1 2017, In : Blood. 129, 22, p. 2971-2979 9 p.

Research output: Contribution to journalReview article

Autoimmune Hemolytic Anemia
Testing
Therapeutic Uses
Therapeutics
Hemolysis
8 Citations (Scopus)

Leukemia-cell proliferation and disease progression in patients with early stage chronic lymphocytic leukemia

Murphy, E. J., Neuberg, D. S., Rassenti, L. Z., Hayes, G., Redd, R., Emson, C., Li, K., Brown, J. R., Wierda, W. G., Turner, S., Greaves, A. W., Zent, C. S., Byrd, J. C., McConnel, C., Barrientos, J., Kay, N. E., Hellerstein, M. K., Chiorazzi, N., Kipps, T. J. & Rai, K. R., Feb 17 2017, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Birth Rate
B-Cell Chronic Lymphocytic Leukemia
Disease Progression
Leukemia
Cell Proliferation
3 Citations (Scopus)

Liver dysfunction in chronic lymphocytic leukemia: Prevalence, outcomes, and pathological findings

Hampel, P. J., Chaffee, K. G., King, R., Simonetto, D., Larson, M. C., Achenbach, S., Call, T. G., Ding, W. D., Kenderian, S., Leis, J. F., Chanan Khan, A. A., Bowen, D. A., Conte, M. J., Schwager, S. M., Hanson, C. A., Slager, S. L., Kay, N. E., Shanafelt, T. D. & Parikh, S. A., Dec 1 2017, In : American Journal of Hematology. 92, 12, p. 1362-1369 8 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Liver Diseases
Liver Function Tests
Survival
Liver

Microvesicles in CLL: Predictor of disease progression/relapse

Maiti, G. P., Kay, N. E. & Ghosh, A. K., Jan 1 2017, In : Oncotarget. 8, 53, p. 90632-90633 2 p.

Research output: Contribution to journalEditorial

Exosomes
Disease Progression
Biomarkers
Recurrence
86 Citations (Scopus)

Pembrolizumab in patients with CLL and Richter transformation or with relapsed CLL

Ding, W. D., LaPlant, B. R., Call, T. G., Parikh, S. A., Leis, J. F., He, R., Shanafelt, T. D., Sinha, S., Le-Rademacher, J., Feldman, A. L., Habermann, T. M., Witzig, T. E., Wiseman, G. A., Lin, Y., Asmus, E., Nowakowski, G. S., Conte, M. J., Bowen, D. A., Aitken, C. N., Van Dyke, D. L. & 15 others, Greipp, P. T., Liu, X., Wu, X., Zhang, H., Secreto, C. R., Tian, S., Braggio, E. D., Wellik, L. E., Micallef, I., Viswanatha, D. S., Yan, H. D., Chanan Khan, A. A., Kay, N. E., Dong, H. M. & Ansell, S. M., Jun 29 2017, In : Blood. 129, 26, p. 3419-3427 9 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Tumors
Blocking Antibodies
Ligands
pembrolizumab
36 Citations (Scopus)

Precancer atlas to drive precision prevention trials

Spira, A., Yurgelun, M. B., Alexandrov, L., Rao, A., Bejar, R., Polyak, K., Giannakis, M., Shilatifard, A., Finn, O. J., Dhodapkar, M., Kay, N. E., Braggio, E. D., Vilar, E., Mazzilli, S. A., Rebbeck, T. R., Garber, J. E., Velculescu, V. E., Disis, M. L., Wallace, D. C. & Lippman, S. M., 2017, In : Cancer Research. 77, 7, p. 1510-1541 32 p.

Research output: Contribution to journalReview article

Atlases
Neoplasms
Immunity
Clone Cells
Drive
12 Citations (Scopus)

Relationship between co-morbidities at diagnosis, survival and ultimate cause of death in patients with chronic lymphocytic leukaemia (CLL): A prospective cohort study

Strati, P., Parikh, S. A., Chaffee, K. G., Kay, N. E., Call, T. G., Achenbach, S. J., Cerhan, J. R., Slager, S. L. & Shanafelt, T. D., 2017, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Cause of Death
Cohort Studies
Prospective Studies
Morbidity
5 Citations (Scopus)

Renal insufficiency is an independent prognostic factor in patients with chronic lymphocytic leukemia

Strati, P., Chaffee, K. G., Achenbach, S. J., Slager, S. L., Leung, N., Call, T. G., Ding, W. D., Parikh, S. A., Kay, N. E. & Shanafelt, T. D., 2017, In : Haematologica. 102, 1, p. e22-e25

Research output: Contribution to journalLetter

B-Cell Chronic Lymphocytic Leukemia
Renal Insufficiency

Reply to S. Opat et al

Brown, J. R. & Kay, N. E., Dec 20 2017, In : Journal of Clinical Oncology. 35, 36, p. 4094-4095 2 p.

Research output: Contribution to journalLetter

2016
2 Citations (Scopus)

Analysis of racial variations in disease characteristics, treatment patterns, and outcomes of patients with chronic lymphocytic leukemia

Nabhan, C., Chaffee, K. G., Slager, S. L., Galanina, N., Achenbach, S. J., Schwager, S. M., Kay, N. E. & Shanafelt, T. D., Jul 1 2016, In : American Journal of Hematology. 91, 7, p. 677-680 4 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Survival
North America
Natural History
Leukemia
4 Citations (Scopus)

A randomized phase II trial comparing chemoimmunotherapy with or without bevacizumab in previously untreated patients with chronic lymphocytic leukemia

Kay, N. E., Strati, P., LaPlant, B. R., Leis, J. F., Nikcevich, D., Call, T. G., Pettinger, A. M., Lesnick, C. E., Hanson, C. A. & Shanafelt, T. D., 2016, In : Oncotarget. 7, 48, p. 78269-78280 12 p.

Research output: Contribution to journalArticle

Pentostatin
B-Cell Chronic Lymphocytic Leukemia
Cyclophosphamide
Disease-Free Survival
Vascular Endothelial Growth Factor A
34 Citations (Scopus)

Arial fibrillation in patients with chronic lymphocytic leukemia (CLL)

Shanafelt, T. D., Parikh, S. A., Noseworthy, P., Goede, V., Chaffee, K. G., Bahlo, J., Call, T. G., Schwager, S. M., Ding, W. D., Eichhorst, B., Fischer, K., Leis, J. F., Chanan Khan, A. A., Hallek, M., Slager, S. L. & Kay, N. E., Nov 24 2016, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-10 10 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Atrial Fibrillation
Incidence
Heart Valve Diseases
Multivariate Analysis
11 Citations (Scopus)

Dynamics of microvesicle generation in B-cell chronic lymphocytic leukemia: implication in disease progression

Boysen, J., Nelson, M., Magzoub, G., Maiti, G. P., Sinha, S., Goswami, M., Vesely, S. K., Shanafelt, T. D., Kay, N. E. & Ghosh, A. K., Sep 6 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Disease Progression
Phenotype
Therapeutics
Ligation
15 Citations (Scopus)

Genomic characterization of high-count MBL cases indicates that early detection of driver mutations and subclonal expansion are predictors of adverse clinical outcome

Barrio, S., Shanafelt, T. D., Ojha, J., Chaffee, K. G., Secreto, C., Kortüm, K. M., Pathangey, S., Van-Dyke, D. L., Slager, S. L., Fonseca, R., Kay, N. E. & Braggio, E. D., Jul 29 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Lymphocytosis
B-Cell Chronic Lymphocytic Leukemia
B-Lymphocytes
Mutation
Clonal Evolution
29 Citations (Scopus)

High-level ROR1 associates with accelerated disease progression in chronic lymphocytic leukemia

Cui, B., Ghia, E. M., Chen, L., Rassenti, L. Z., DeBoever, C., Widhopf, G. F., Yu, J., Neuberg, D. S., Wierda, W. G., Rai, K. R., Kay, N. E., Brown, J. R., Jones, J. A., Gribben, J. G., Frazer, K. A. & Kipps, T. J., Dec 22 2016, In : Blood. 128, 25, p. 2931-2940 10 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Disease Progression
Chemical activation
Gene expression
Genes
40 Citations (Scopus)

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

Berndt, S. I., Camp, N. J., Skibola, C. F., Vijai, J., Wang, Z., Gu, J., Nieters, A., Kelly, R. S., Smedby, K. E., Monnereau, A., Cozen, W., Cox, A., Wang, S. S., Lan, Q., Teras, L. R., Machado, M., Yeager, M., Brooks-Wilson, A. R., Hartge, P., Purdue, M. P. & 106 others, Birmann, B. M., Vajdic, C. M., Cocco, P., Zhang, Y., Giles, G. G., Zeleniuch-Jacquotte, A., Lawrence, C., Montalvan, R., Burdett, L., Hutchinson, A., Ye, Y., Call, T. G., Shanafelt, T. D., Novak, A. J., Kay, N. E., Liebow, M., Cunningham, J. M., Allmer, C., Hjalgrim, H., Adami, H. O., Melbye, M., Glimelius, B., Chang, E. T., Glenn, M., Curtin, K., Cannon-Albright, L. A., Diver, W. R., Link, B. K., Weiner, G. J., Conde, L., Bracci, P. M., Riby, J., Arnett, D. K., Zhi, D., Leach, J. M., Holly, E. A., Jackson, R. D., Tinker, L. F., Benavente, Y., Sala, N., Casabonne, D., Becker, N., Boffetta, P., Brennan, P., Foretova, L., Maynadie, M., McKay, J., Staines, A., Chaffee, K. G., Achenbach, S. J., Vachon, C. M., Goldin, L. R., Strom, S. S., Leis, J. F., Weinberg, J. B., Caporaso, N. E., Norman, A. D., De Roos, A. J., Morton, L. M., Severson, R. K., Riboli, E., Vineis, P., Kaaks, R., Masala, G., Weiderpass, E., Chirlaque, M. D., Vermeulen, R. C. H., Travis, R. C., Southey, M. C., Milne, R. L., Albanes, D., Virtamo, J., Weinstein, S., Clavel, J., Zheng, T., Holford, T. R., Villano, D. J., Maria, A., Spinelli, J. J., Gascoyne, R. D., Connors, J. M., Bertrand, K. A., Giovannucci, E., Kraft, P., Kricker, A., Turner, J., Ennas, M. G., Ferri, G. M., Miligi, L., Liang, L., Ma, B., Huang, J., Crouch, S., Park, J. H., Chatterjee, N., North, K. E., Snowden, J. A., Wright, J., Fraumeni, J. F., Offit, K., Wu, X., De Sanjose, S., Cerhan, J. R., Chanock, S. J., Rothman, N. & Slager, S. L., Mar 9 2016, In : Nature Communications. 7, 10933.

Research output: Contribution to journalArticle

leukemias
genome
Genome-Wide Association Study
B-Cell Chronic Lymphocytic Leukemia
loci
12 Citations (Scopus)

Ofatumumab monotherapy as a consolidation strategy in patients with previously untreated chronic lymphocytic leukaemia: a phase 2 trial

Strati, P., Lanasa, M., Call, T. G., Leis, J. F., Brander, D. M., LaPlant, B. R., Pettinger, A. M., Ding, W. D., Parikh, S. A., Hanson, C. A., Chanan Khan, A. A., Bowen, D. A., Conte, M., Kay, N. E. & Shanafelt, T. D., Sep 1 2016, In : The Lancet Haematology. 3, 9, p. e407-e414

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Survival
losoxantrone
Therapeutics
ofatumumab
13 Citations (Scopus)

Pharmacovigilance during ibrutinib therapy for chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) in routine clinical practice

Finnes, H. D., Chaffee, K. G., Call, T. G., Ding, W. D., Kenderian, S., Bowen, D. A., Conte, M., McCullough, K. B., Merten, J. A., Bartoo, G. T., Smith, M. D., Leis, J., Chanan Khan, A. A., Schwager, S. M., Slager, S. L., Kay, N. E., Shanafelt, T. D. & Parikh, S. A., Nov 7 2016, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-8 8 p.

Research output: Contribution to journalArticle

Pharmacovigilance
B-Cell Chronic Lymphocytic Leukemia
Cytochrome P-450 CYP3A
Therapeutics
Clinical Trials
16 Citations (Scopus)

Real-world clinical experience in the Connect® chronic lymphocytic leukaemia registry: a prospective cohort study of 1494 patients across 199 US centres

Mato, A., Nabhan, C., Kay, N. E., Weiss, M. A., Lamanna, N., Kipps, T. J., Grinblatt, D. L., Flinn, I. W., Kozloff, M. F., Flowers, C. R., Farber, C. M., Kiselev, P., Swern, A. S., Sullivan, K., Flick, E. D. & Sharman, J. P., Dec 1 2016, In : British Journal of Haematology. 175, 5, p. 892-903 12 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Registries
Cohort Studies
Prospective Studies
Fluorescence
6 Citations (Scopus)

Relationship of blood monocytes with chronic lymphocytic leukemia aggressiveness and outcomes: a multi-institutional study

Friedman, D. R., Sibley, A. B., Owzar, K., Chaffee, K. G., Slager, S. L., Kay, N. E., Hanson, C. A., Ding, W. D., Shanafelt, T. D., Weinberg, J. B. & Wilcox, R. A., Jul 1 2016, In : American Journal of Hematology. 91, 7, p. 687-691 5 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Monocytes
Cell Survival
Cellular Microenvironment
Tumor Microenvironment
17 Citations (Scopus)

Risk of non-hematologic cancer in individuals with high-count monoclonal B-cell lymphocytosis

Solomon, B. M., Chaffee, K. G., Moreira, J., Schwager, S. M., Cerhan, J. R., Call, T. G., Kay, N. E., Slager, S. L. & Shanafelt, T. D., Feb 1 2016, In : Leukemia. 30, 2, p. 331-336 6 p.

Research output: Contribution to journalArticle

Lymphocytosis
B-Lymphocytes
B-Cell Chronic Lymphocytic Leukemia
Neoplasms
Flow Cytometry
5 Citations (Scopus)

SphK1 inhibitor potentiates the anti-cancer effect of EGCG on leukaemia cells

Tsukamoto, S., Kumazoe, M., Huang, Y., Lesnick, C., Kay, N. E., Shanafelt, T. D. & Tachibana, H., 2016, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle

25 Citations (Scopus)

The chronic lymphocytic leukemia international prognostic index predicts time to first treatment in early CLL: Independent validation in a prospective cohort of early stage patients

Molica, S., Shanafelt, T. D., Giannarelli, D., Gentile, M., Mirabelli, R., Cutrona, G., Levato, L., Di Renzo, N., Di Raimondo, F., Musolino, C., Angrilli, F., Famà, A., Recchia, A. G., Chaffee, K. G., Neri, A., Kay, N. E., Ferrarini, M. & Morabito, F., Nov 1 2016, In : American Journal of Hematology. 91, 11, p. 1090-1095 6 p.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Therapeutics
Survival
Observational Studies
Mutation
32 Citations (Scopus)

The Dohner fluorescence in situ hybridization prognostic classification of chronic lymphocytic leukaemia (CLL): The CLL Research Consortium experience

Van Dyke, D. L., Werner, L., Rassenti, L. Z., Neuberg, D., Ghia, E., Heerema, N. A., Dal Cin, P., Dell Aquila, M., Sreekantaiah, C., Greaves, A. W., Kipps, T. & Kay, N. E., 2016, (Accepted/In press) In : British Journal of Haematology.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Fluorescence In Situ Hybridization
Research
Survival
Therapeutics
5 Citations (Scopus)

Tris (dibenzylideneacetone) dipalladium: a small-molecule palladium complex is effective in inducing apoptosis in chronic lymphocytic leukemia B-cells

Kay, N. E., Sassoon, T., Secreto, C., Sinha, S., Shanafelt, T. D., Ghosh, A. K. & Arbiser, J. L., Jan 17 2016, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-8 8 p.

Research output: Contribution to journalArticle

Palladium
B-Cell Chronic Lymphocytic Leukemia
Apoptosis
Apoptosis Regulatory Proteins
Ribosomal Protein S6
2015
9 Citations (Scopus)

A progression-risk score to predict treatment-free survival for early stage chronic lymphocytic leukemia patients

Gentile, M., Shanafelt, T. D., Cutrona, G., Molica, S., Tripepi, G., Alvarez, I., Mauro, F. R., Di Renzo, N., Di Raimondo, F., Vincelli, I., Todoerti, K., Matis, S., Musolino, C., Fabris, S., Vigna, E., Levato, L., Zupo, S., Angrilli, F., Consoli, U., Festini, G. & 10 others, Longo, G., Cortelezzi, A., Arcari, A., Federico, M., Mannina, D., Recchia, A. G., Neri, A., Kay, N. E., Ferrarini, M. & Morabito, F., Dec 9 2015, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

B-Cell Chronic Lymphocytic Leukemia
Survival
Therapeutics