Nathan W Cummins, MD

  • 531 Citations
  • 14 Scopus h-Index
20082019
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Research Output 2008 2019

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Article
2019

HIV elite control is associated with reduced TRAILshort expression

Paim, A. C., Cummins, N. W., Natesampillai, S., Garcia-Rivera, E., Kogan, N., Neogi, U., Sönnerborg, A., Sperk, M., Bren, G. D., Deeks, S., Polley, E. & Badley, A. D., Sep 1 2019, In : AIDS. 33, 11, p. 1757-1763 7 p.

Research output: Contribution to journalArticle

HIV-1
HIV
Blood Cells
Cell Death
HIV Infections

Trailshort protects against CD4 T cell death during acute HIV infection

Natesampillai, S., Paim, A. C., Cummins, N. W., Chandrasekar, A. P., Bren, G. D., Lewin, S. R., Kiem, H. P. & Badley, A. D., Aug 1 2019, In : Journal of Immunology. 203, 3, p. 718-724 7 p.

Research output: Contribution to journalArticle

HIV Infections
Cell Death
T-Lymphocytes
HIV-1
Clustered Regularly Interspaced Short Palindromic Repeats
2018
11 Citations (Scopus)

An advanced BLT-humanized mouse model for extended HIV-1 cure studies

Lavender, K. J., Pace, C., Sutter, K., Messer, R. J., Pouncey, D. L., Cummins, N. W., Natesampillai, S., Zheng, J., Goldsmith, J., Widera, M., Van Dis, E. S., Phillips, K., Race, B., Dittmer, U., Kukolj, G. & Hasenkrug, K. J., Jan 2 2018, In : AIDS. 32, 1, p. 1-10 10 p.

Research output: Contribution to journalArticle

Thymus Gland
HIV-1
Bone Marrow
Liver
Therapeutics
5 Citations (Scopus)

Both HIV-Infected and uninfected cells express TRAILshort, which confers TRAIL resistance upon bystander cells within the microenvironment

Nie, Z., Aboulnasr, F., Natesampillai, S., Burke, S. P., Krogman, A., Bren, G. D., Chung, T. D. Y., Anderson, J. R., Smart, M. K., Katzmann, D. J., Rajagopalan, G., Cummins, N. W. & Badley, A. D., Feb 1 2018, In : Journal of Immunology. 200, 3, p. 1110-1123 14 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand
Cellular Microenvironment
HIV
TNF-Related Apoptosis-Inducing Ligand Receptors
Proteasome Endopeptidase Complex
2 Citations (Scopus)

HIV protease-generated Casp8p41, when bound and inactivated by Bcl2, is degraded by the proteasome

Natesampillai, S., Cummins, N. W., Nie, Z., Sampath, R., Baker, J. V., Henry, K., Pinzone, M., O'Doherty, U., Polley, E., Bren, G. D., Katzmann, D. J. & Badley, A. D., Jul 1 2018, In : Journal of Virology. 92, 13, e00037-18.

Research output: Contribution to journalArticle

HIV Protease
proteasome endopeptidase complex
Proteasome Endopeptidase Complex
cell death
Cell Death
4 Citations (Scopus)

Risk of suicidal behavior with use of efavirenz: Results from the strategic timing of antiretroviral treatment trial

Arenas-Pinto, A., Grund, B., Sharma, S., Martinez, E., Cummins, N. W., Fox, J., Klingman, K. L., Sedlacek, D., Collins, S., Flynn, P. M., Chasanov, W. M., Kedem, E., Katlama, C., Sierra-Madero, J., Afonso, C., Brouwers, P. & Cooper, D. A., Jul 18 2018, In : Clinical Infectious Diseases. 67, 3, p. 420-429 10 p.

Research output: Contribution to journalArticle

efavirenz
Risk-Taking
Mental Disorders
Group Psychotherapy
Therapeutics

Transient Loss of HIV-1 DNA in an HIV-1 Positive Patient After Kidney Transplantation: A Case Report

Paim, A. C., Rizza, S., Badley, A. D., Prieto, M., Taler, S. J., Chong, P. P. & Cummins, N. W., Jan 1 2018, (Accepted/In press) In : American Journal of Medicine.

Research output: Contribution to journalArticle

Kidney Transplantation
HIV-1
DNA
2017
2 Citations (Scopus)

Epidemiology, risk factors, and outcomes of infections in patients undergoing liver transplantation for hilar cholangiocarcinoma

Ramanan, P., Cummins, N. W., Wilhelm, M. P., Heimbach, J. K., Dierkhising, R., Kremers, W. K., Rosen, C. B., Gores, G. J. & Razonable, R. R., 2017, (Accepted/In press) In : Clinical Transplantation.

Research output: Contribution to journalArticle

Klatskin Tumor
Liver Transplantation
Epidemiology
Infection
Pathologic Constriction
17 Citations (Scopus)

Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study

Cummins, N. W., Rizza, S., Litzow, M. R., Hua, S., Lee, G. Q., Einkauf, K., Chun, T. W., Rhame, F., Baker, J. V., Busch, M. P., Chomont, N., Dean, P. G., Fromentin, R., Haase, A. T., Hampton, D., Keating, S. M., Lada, S. M., Lee, T. H., Natesampillai, S., Richman, D. D. & 7 others, Schacker, T. W., Wietgrefe, S., Yu, X. G., Yao, J. D., Zeuli, J., Lichterfeld, M. & Badley, A. D., Nov 1 2017, In : PLoS Medicine. 14, 11, e1002461.

Research output: Contribution to journalArticle

HIV-1
Stem Cells
HIV
Transplants
Stem Cell Transplantation

Increasing procaspase 8 expression using repurposed drugs to induce HIV infected cell death in ex vivo patient cells

Sampath, R., Cummins, N. W., Natesampillai, S., Bren, G. D., Chung, T. D., Baker, J., Henry, K., Pagliuzza, A. & Badley, A. D., Jun 1 2017, In : PLoS One. 12, 6, e0179327.

Research output: Contribution to journalArticle

Drug Repositioning
Caspase 8
Cell death
cell death
Cell Death

Lysinibacillus massiliensis panniculitis masquerading as erythema nodosum: A case report

Jin, J. J., Keith, P. J., Cummins, N. W., Kane, S. V., Pritt, B. S. & Sanchez, J. L., Mar 1 2017, In : Open Forum Infectious Diseases. 4, 2, ofx072.

Research output: Contribution to journalArticle

Panniculitis
Erythema Nodosum
Bacillus
Crohn Disease
Sepsis
16 Citations (Scopus)

Maintenance of the HIV reservoir is antagonized by selective BCL2 inhibition

Cummins, N. W., Sainski-Nguyen, A. M., Natesampillai, S., Aboulnasr, F., Kaufmann, S. H. & Badley, A. D., Jun 1 2017, In : Journal of Virology. 91, 11, e00012-17.

Research output: Contribution to journalArticle

Maintenance
HIV
cells
Infection
deterioration
2016

23rd conference on retroviruses and opportunistic infections (CROI 2016) Boston, Massachusetts, USA - February 22-25, 2016

Rizza, S., Cummins, N. W., Hoffman-Therry, M. & Temesgen, Z., Mar 1 2016, In : Drugs of the Future. 41, 3, p. 203-212 10 p.

Research output: Contribution to journalArticle

Retroviridae Infections
Opportunistic Infections
HIV
Anti-Retroviral Agents
Administrative Personnel

Is abnormal urine protein/osmolality ratio associated with abnormal renal function in patients receiving tenofovir disoproxil fumarate?

Marcelin, J. R., Berg, M. L., Tan, E. M., Amer, H., Cummins, N. W. & Rizza, S., Feb 1 2016, In : PLoS One. 11, 2, e0149562.

Research output: Contribution to journalArticle

Tenofovir
renal function
osmolality
Osmolar Concentration
urine
31 Citations (Scopus)

Prime, shock, and kill: Priming CD4 T cells from HIV patients with a BCL-2 antagonist before HIV reactivation reduces HIV reservoir size

Cummins, N. W., Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., De Araujo Correia, M. C. M., Sampath, R., Rizza, S., O'Brien, D., Yao, J. D., Kaufmann, S. H. & Badley, A. D., Apr 1 2016, In : Journal of Virology. 90, 8, p. 4032-4048 17 p.

Research output: Contribution to journalArticle

antagonists
Shock
T-lymphocytes
HIV
T-Lymphocytes
2015

Can HIV be cured and should we try?

Cummins, N. W. & Badley, A. D., Jun 1 2015, In : Mayo Clinic Proceedings. 90, 6, p. 705-709 5 p.

Research output: Contribution to journalArticle

Virus Latency
Anti-Retroviral Agents
AIDS Vaccines
Viral Load
HIV Infections
3 Citations (Scopus)

Casp8p41 and HIV

Cummins, N. W. & Badley, A. D., 2015, In : Oncotarget. 6, 27, p. 23042-23043 2 p.

Research output: Contribution to journalArticle

Viral Drug Resistance
HIV Protease
CD4-Positive T-Lymphocytes
Enzyme Activation
Caspase 9

Fever and cardiac arrest in a patient with a left ventricular assist device

Tan, E. M., Marcelin, J. R., Tande, A. J., Rizza, S. & Cummins, N. W., 2015, In : Open Forum Infectious Diseases. 2, 2, ofv033.

Research output: Contribution to journalArticle

Heart-Assist Devices
Heart Arrest
Fever
Deer
Anaplasma
12 Citations (Scopus)

Investigation of Efavirenz Discontinuation in Multi-ethnic Populations of HIV-positive Individuals by Genetic Analysis

Cummins, N. W., Neuhaus, J., Chu, H., Neaton, J., Wyen, C., Rockstroh, J. K., Skiest, D. J., Boyd, M. A., Khoo, S., Rotger, M., Telenti, A., Weinshilboum, R. M. & Badley, A. D., Jul 1 2015, In : EBioMedicine. 2, 7, p. 706-712 7 p.

Research output: Contribution to journalArticle

efavirenz
HIV
Population
Cytochrome P-450 CYP3A
Polymorphism
2014
16 Citations (Scopus)

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., Cummins, N. W., Correia, C., Meng, X. W., Tarara, J. E., Ramirez-Alvarado, M., Katzmann, D. J., Ochsenbauer, C., Kappes, J. C., Kaufmann, S. H. & Badley, A. D., 2014, In : Journal of Cell Biology. 206, 7, p. 867-876 10 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
HIV
T-Lymphocytes
Caspase 8
Cell Death
1 Citation (Scopus)

Correction to Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation [Journal of Cell Biology, 206, 7, (2014), 867-876]

Sainski, A. M., Dai, H., Natesampillai, S., Pang, Y-P., Bren, G. D., Cummins, N. W., Correia, C., Wei Meng, X., Tarara, J. E., Ramirez-Alvarado, M., Katzmann, D. J., Ochsenbauer, C., Kappes, J. C., Kaufmann, S. H. & Badley, A. D., 2014, In : Journal of Cell Biology. 207, 1, p. 159 1 p.

Research output: Contribution to journalArticle

HIV Protease
Cell Biology
T-Lymphocytes
Prosthesis-Related Infections
Knee Prosthesis
Inflammation Mediators
Hip Prosthesis
Knee Replacement Arthroplasties
7 Citations (Scopus)

Short communication: CD4 T cell declines occurring during suppressive antiretroviral therapy reflect continued production of Casp8p41

Cummins, N. W., Neuhaus, J., Sainski, A. M., Strausbauch, M. A., Wettstein, P. J., Lewin, S. R., Plana, M., Rizza, S., Temesgen, Z., Touloumi, G., Freiberg, M., Neaton, J. & Badley, A. D., May 30 2014, In : AIDS Research and Human Retroviruses. 30, 5, p. 476-479 4 p.

Research output: Contribution to journalArticle

Communication
T-Lymphocytes
HIV
Therapeutics
CD4 Lymphocyte Count
26 Citations (Scopus)

Stability in the cumulative incidence, severity and mortality of 101 cases of invasive mucormycosis in high-risk patients from 1995 to 2011: A comparison of eras immediately before and after the availability of voriconazole and echinocandin-amphotericin combination therapies

Abidi, M. Z., Sohail, M. R., Cummins, N. W., Wilhelm, M., Wengenack, N., Brumble, L., Shah, H., Jane Hata, D., Mccullough, A., Wendel, A., Vikram, H. R., Kusne, S., Litzow, M. R., Letendre, L., Lahr, B. D., Poeschla, E. & Walker, R. C., Nov 1 2014, In : Mycoses. 57, 11, p. 687-698 12 p.

Research output: Contribution to journalArticle

Echinocandins
Mucormycosis
Amphotericin B
Mortality
Incidence
2013
Retroviridae Infections
Opportunistic Infections
Chronic Hepatitis C
Virus Diseases
Hepacivirus
13 Citations (Scopus)

Anti-apoptotic mechanisms of HIV: Lessons and novel approaches to curing HIV

Cummins, N. W. & Badley, A. D., Sep 2013, In : Cellular and Molecular Life Sciences. 70, 18, p. 3355-3363 9 p.

Research output: Contribution to journalArticle

HIV
Viral Cytopathogenic Effect
Cell Death
Viruses
Infection
30 Citations (Scopus)

HIV replication alters the composition of extrinsic pathway coagulation factors and increases thrombin generation.

Baker, J. V., Brummel-Ziedins, K., Neuhaus, J., Duprez, D., Cummins, N. W., Dalmau, D., DeHovitz, J., Lehmann, C., Sullivan, A., Woolley, I., Kuller, L., Neaton, J. D., Tracy, R. P. & INSIGHT SMART Study Team, SMART. S. T., Aug 2013, In : Journal of the American Heart Association. 2, 4

Research output: Contribution to journalArticle

Blood Coagulation Factors
Thrombin
HIV
Antithrombins
Therapeutics
21 Citations (Scopus)

The Association between Serum Biomarkers and Disease Outcome in Influenza A(H1N1)pdm09 Virus Infection: Results of Two International Observational Cohort Studies

Davey, R. T., Lynfield, R., Dwyer, D. E., Losso, M. H., Cozzi-Lepri, A., Wentworth, D., Lane, H. C., Dewar, R., Rupert, A., Metcalf, J. A., Pett, S. L., Uyeki, T. M., Bruguera, J. M., Angus, B., Cummins, N. W., Lundgren, J. & Neaton, J. D., Feb 27 2013, In : PLoS One. 8, 2, e57121.

Research output: Contribution to journalArticle

H1N1 Subtype Influenza A Virus
Biomarkers
Virus Diseases
cohort studies
Viruses
2012
24 Citations (Scopus)

Heme oxygenase-1 regulates the immune response to influenza virus infection and vaccination in aged mice

Cummins, N. W., Weaver, E. A., May, S. M., Croatt, A. J., Foreman, O., Kennedy, R. B., Poland, G. A., Barry, M. A., Nath, K. A. & Badley, A. D., Jul 2012, In : FASEB Journal. 26, 7, p. 2911-2918 8 p.

Research output: Contribution to journalArticle

Heme Oxygenase-1
Virus Diseases
Orthomyxoviridae
Viruses
Vaccination
3 Citations (Scopus)

Multiple pyogenic liver abscesses caused by Eggerthella lenta treated with ertapenem: A case report

Elias, R. M., Khoo, S. Y., Pupaibool, J., Nienaber, J. H. & Cummins, N. W., 2012, In : Case Reports in Medicine. 2012, 718130.

Research output: Contribution to journalArticle

Pyogenic Liver Abscess
Liver Abscess
Bacillus
Drainage
Infection
2011
6 Citations (Scopus)

Human immunodeficiency virus envelope protein Gp120 induces proliferation but not apoptosis in osteoblasts at physiologic concentrations

Cummins, N. W., Klicpera, A., Sainski, A. M., Bren, G. D., Khosla, S., Westendorf, J. J. & Badley, A. D., Sep 12 2011, In : PLoS One. 6, 9, e24876.

Research output: Contribution to journalArticle

Human Immunodeficiency Virus env Gene Products
osteoblasts
Osteoblasts
Human immunodeficiency virus
apoptosis
10 Citations (Scopus)

Isolation of a TRAIL antagonist from the serum of HIV-infected patients

Schnepple, D. J., Shepard, B., Bren, G. D., Cummins, N. W., Natesampillai, S., Trushin, S., Algeciras-Schimnich, A., Meng, X. W., Sainski, A. M., Rizza, S., Kaufmann, S. H. & Badley, A. D., Oct 14 2011, In : Journal of Biological Chemistry. 286, 41, p. 35742-35754 13 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand
HIV
Serum
TNF-Related Apoptosis-Inducing Ligand Receptors
HIV Infections
15 Citations (Scopus)

The HIV-1-specific protein Casp8p41 induces death of infected cells through Bax/Bak

Sainski, A. M., Natesampillai, S., Cummins, N. W., Bren, G. D., Taylor, J., Saenz, D. T., Poeschla, E. M. & Badley, A. D., Aug 2011, In : Journal of Virology. 85, 16, p. 7965-7975 11 p.

Research output: Contribution to journalArticle

Human immunodeficiency virus 1
caspase-9
HIV-1
cell death
Cell Death
2010
4 Citations (Scopus)

Casp8p41 expression in primary T cells induces a proinflammatory response

Taylor, J. A., Cummins, N. W., Bren, G. D., Rizza, S., Kolbert, C. P., Behrens, M. D., Knutson, K. L., Kahl, J. C., Asmann, Y. & Badley, A. D., Jun 1 2010, In : AIDS. 24, 9, p. 1251-1258 8 p.

Research output: Contribution to journalArticle

HIV
T-Lymphocytes
NF-kappa B
Microarray Analysis
Cytokines
15 Citations (Scopus)

How much Gp120 is there?

Cummins, N. W., Rizza, S. & Badley, A. D., Apr 15 2010, In : Journal of Infectious Diseases. 201, 8, p. 1273-1274 2 p.

Research output: Contribution to journalArticle

HIV Envelope Protein gp120
Lymphoid Tissue
Tissue Distribution
HIV Infections
11 Citations (Scopus)

Intracellular Casp8p41 content is inversely associated with CD4 T cell count

Cummins, N. W., Jiang, W., McGinty, J., Bren, G. D., Bosch, R. J., Landay, A., Deeks, S. G., Martin, J. N., Douek, D., Lederman, M. M., Brenchley, J. & Badley, A. D., Aug 1 2010, In : Journal of Infectious Diseases. 202, 3, p. 386-391 6 p.

Research output: Contribution to journalArticle

CD4 Lymphocyte Count
T-Lymphocytes
HIV
Bacterial DNA
Caspase 8
116 Citations (Scopus)

Mechanisms of HIV-associated lymphocyte apoptosis: 2010

Cummins, N. W. & Badley, A. D., Nov 2010, In : Cell Death and Disease. 1, 11, e99.

Research output: Contribution to journalArticle

Virus Diseases
HIV
Lymphocytes
Apoptosis
Viral Proteins
12 Citations (Scopus)

Patients with discordant responses to antiretroviral therapy have impaired killing of HIV-infected T cells

Natesampillai, S., Nie, Z., Cummins, N. W., Jochmans, D., Bren, G. D., Angel, J. B. & Badley, A. D., Nov 2010, In : PLoS Pathogens. 6, 11, e1001213.

Research output: Contribution to journalArticle

HIV Protease
HIV
Cell Death
T-Lymphocytes
Peptide Hydrolases
5 Citations (Scopus)
Hepacivirus
Interferons
Tumor Necrosis Factor-alpha
HIV
Apoptosis
2009
42 Citations (Scopus)
Cytomegalovirus
Transplantation
T-Lymphocytes
Mental Competency
Late Onset Disorders
27 Citations (Scopus)

The TRAIL to viral pathogenesis: The good, the bad and the ugly

Cummins, N. W. & Badley, A. D., 2009, In : Current Molecular Medicine. 9, 4, p. 495-505 11 p.

Research output: Contribution to journalArticle

Virus Diseases
Antiviral Agents
Apoptosis
Viruses
Cytokines
2008
21 Citations (Scopus)

Infected cell killing by HIV-1 protease promotes NF-κB dependent HIV-1 replication

Bren, G. D., Whitman, J., Cummins, N. W., Shepard, B., Rizz, S. A., Trushin, S. A. & Badley, A. D., May 7 2008, In : PLoS One. 3, 5, e2112.

Research output: Contribution to journalArticle

Caspase 8
Human immunodeficiency virus 1
T-cells
HIV-1
proteinases