Nathan P Staff, MD, PhD

  • 1775 Citations
  • 20 Scopus h-Index
19962019
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Research Output 1996 2019

  • 1775 Citations
  • 20 Scopus h-Index
  • 53 Article
  • 6 Review article
  • 3 Editorial
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Article
2019

Case-Based Learning in Translational Biomedical Research Education: Providing Realistic and Adaptive Skills for Early-Career Scientists

Greenberg-Worisek, A. J., Campbell, K. A., Klee, E. W., Staff, N. P., Schimmenti, L. A., Weavers, K. M., Ekker, S. C. & Windebank, A. J., Feb 1 2019, In : Academic medicine : journal of the Association of American Medical Colleges. 94, 2, p. 213-216 4 p.

Research output: Contribution to journalArticle

career
science
learning
education
medicine

Clinical spectrum of neuropathy after primary total knee arthroplasty: A series of 54 cases

Speelziek, S. J. A., Staff, N. P., Johnson, R. L., Sierra, R. J. & Laughlin, R. S., Jan 1 2019, In : Muscle and Nerve.

Research output: Contribution to journalArticle

Knee Replacement Arthroplasties
Lumbosacral Plexus
Peroneal Nerve
Anesthesia
Confidence Intervals

DNA methylation patterns in human iPSC-derived sensory neuronal differentiation

Ankam, S., Rovini, A., Baheti, S., Hrstka, R., Wu, Y., Schmidt, K., Wang, H., Madigan, N., Koenig, L. S., Stelzig, K., Resch, Z., Klein, C. J., Sun, Z. & Staff, N. P., Jan 1 2019, In : Epigenetics.

Research output: Contribution to journalArticle

Sensory Receptor Cells
DNA Methylation
Induced Pluripotent Stem Cells
Peripheral Nervous System
Genome

Dominant collagen XII mutations cause a distal myopathy

Mohassel, P., Liewluck, T., Hu, Y., Ezzo, D., Ogata, T., Saade, D., Neuhaus, S., Bolduc, V., Zou, Y., Donkervoort, S., Medne, L., Sumner, C. J., Dyck, P. J., Wierenga, K. J., Tennekoon, G., Finkel, R. S., Chen, J., Winder, T. L., Staff, N. P., Foley, A. R. & 2 others, Koch, M. & Bönnemann, C. G., Jan 1 2019, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

Open Access
Distal Myopathies
Collagen
Mutation
Muscular Diseases
Small Interfering RNA
2018
17 Citations (Scopus)

Amyotrophic Lateral Sclerosis: An Update for 2018

Oskarsson, B., Gendron, T. D. & Staff, N. P., Jan 1 2018, (Accepted/In press) In : Mayo Clinic Proceedings.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Riluzole
Drug Approval
Excitatory Amino Acid Antagonists
Chromosomes, Human, Pair 9

A treatable hypertrophic neuropathy

Pinto, M. V., Spinner, R. J. & Staff, N. P., Jan 1 2018, (Accepted/In press) In : Practical Neurology.

Research output: Contribution to journalArticle

Chronic Inflammatory Demyelinating Polyradiculoneuropathy
18 Citations (Scopus)
Peripheral Nervous System Diseases
Incidence
International Classification of Diseases
Drug Therapy
Pain
3 Citations (Scopus)

Somatotopic heat pain thresholds and intraepidermal nerve fibers in health

Davies, J. L., Engelstad, J. K., E. Gove, L., Linbo, L. K., Carter, R. E., Lynch, C., Staff, N. P., Klein, C. J., Dyck, P. J. B., Herrmann, D. N. & Dyck, P. J., Oct 1 2018, In : Muscle and Nerve. 58, 4, p. 509-516 8 p.

Research output: Contribution to journalArticle

Pain Threshold
Nerve Fibers
Hot Temperature
Health
Healthy Volunteers
2017
13 Citations (Scopus)

A pilot study of minocycline for the prevention of paclitaxel-associated neuropathy: ACCRU study RU221408I

Pachman, D. R., Dockter, T., Zekan, P. J., Fruth, B., Ruddy, K. J., Ta, L. E., Lafky, J. M., Dentchev, T., Le-Lindqwister, N. A., Sikov, W. M., Staff, N. P., Beutler, A. S. & Loprinzi, C. L., May 27 2017, (Accepted/In press) In : Supportive Care in Cancer. p. 1-10 10 p.

Research output: Contribution to journalArticle

Minocycline
Paclitaxel
Peripheral Nervous System Diseases
Drug Therapy
Acute Pain
26 Citations (Scopus)
Polyneuropathies
Opioid Analgesics
Mortality
Therapeutics
Prescriptions
9 Citations (Scopus)

Comprehensive immune profiling reveals substantial immune system alterations in a subset of patients with amyotrophic lateral sclerosis

Gustafson, M., Staff, N. P., Bornschlegl, S., Butler, G. W., Maas, M. L., Kazamel, M., Zubair, A., Gastineau, D. A., Windebank, A. J. & Dietz, A. B., Jul 1 2017, In : PLoS One. 12, 7, e0182002.

Research output: Contribution to journalArticle

Immune system
Amyotrophic Lateral Sclerosis
Biomarkers
immune system
Immune System
1 Citation (Scopus)

Genome editing technologies and their potential to treat neurologic disease

Madigan, N. N., Staff, N. P., Windebank, A. J. & Benarroch, E. E., Oct 17 2017, In : Neurology. 89, 16, p. 1739-1748 10 p.

Research output: Contribution to journalArticle

Nervous System Diseases
Technology
Gene Editing
72 Citations (Scopus)

Neurological Complications Associated With Anti-Programmed Death 1 (PD-1) Antibodies

Kao, J. C., Liao, B., Markovic, S. N., Klein, C. J., Naddaf, E., Staff, N. P., Liewluck, T., Hammack, J. E., Sandroni, P., Finnes, H. & Mauermann, M. M., Oct 1 2017, In : JAMA Neurology. 74, 10, p. 1216-1222 7 p.

Research output: Contribution to journalArticle

Antibodies
Therapeutics
Muscular Diseases
Monoclonal Antibodies
Polyradiculoneuropathy
2016
7 Citations (Scopus)

Adult-onset respiratory insufficiency, scoliosis, and distal joint hyperlaxity in patients with multiminicore disease due to novel Megf10 mutations

Liewluck, T., Milone, M., Tian, X., Engel, A. G., Staff, N. P. & Wong, L. J., Jun 1 2016, In : Muscle and Nerve. 53, 6, p. 984-988 5 p.

Research output: Contribution to journalArticle

Scoliosis
Respiratory Insufficiency
Joints
Muscular Diseases
Mutation
16 Citations (Scopus)

Comparison of oxaliplatin and paclitaxel-induced neuropathy (Alliance A151505)

Pachman, D. R., Qin, R., Seisler, D., Smith, E. M. L., Kaggal, S., Novotny, P., Ruddy, K. J., Lafky, J. M., Ta, L. E., Beutler, A. S., Wagner-Johnston, N. D., Staff, N. P., Grothey, A. F., Dougherty, P. M., Cavaletti, G. & Loprinzi, C. L., Aug 18 2016, (Accepted/In press) In : Supportive Care in Cancer. p. 1-10 10 p.

Research output: Contribution to journalArticle

oxaliplatin
Paclitaxel
Drug Therapy
Foot
Therapeutics
6 Citations (Scopus)

Neurotoxicity to DRG neurons varies between rodent strains treated with cisplatin and bortezomib

Podratz, J. L., Kulkarni, A., Pleticha, J., Kanwar, R., Beutler, A. S., Staff, N. P. & Windebank, A. J., Mar 15 2016, In : Journal of the Neurological Sciences. 362, p. 131-135 5 p.

Research output: Contribution to journalArticle

Diagnosis-Related Groups
Spinal Ganglia
Cisplatin
Rodentia
Peripheral Nervous System Diseases
34 Citations (Scopus)

Safety of intrathecal autologous adipose-derived mesenchymal stromal cells in patients with ALS

Staff, N. P., Madigan, N. N., Morris, J., Jentoft, M., Sorenson, E. J., Butler, G., Gastineau, D., Dietz, A. B. & Windebank, A. J., Nov 22 2016, In : Neurology. 87, 21, p. 2230-2234 5 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Mesenchymal Stromal Cells
Safety
Cell- and Tissue-Based Therapy
Disease Progression
2 Citations (Scopus)

The immune system continues to knock at the ALS door

Staff, N. P. & Appel, S. H., Jun 1 2016, In : Neuromuscular Disorders. 26, 6, p. 335-336 2 p.

Research output: Contribution to journalArticle

Immune System
2015
17 Citations (Scopus)

A safety study on intrathecal delivery of autologous mesenchymal stromal cells in rabbits directly supporting Phase I human trials

Chen, B. K., Staff, N. P., Knight, A. M., Nesbitt, J. J., Butler, G. W., Padley, D. J., Parisi, J. E., Dietz, A. B. & Windebank, A. J., May 1 2015, In : Transfusion. 55, 5, p. 1013-1020 8 p.

Research output: Contribution to journalArticle

Mesenchymal Stromal Cells
Cerebrospinal Fluid
Rabbits
Safety
Neurodegenerative Diseases
23 Citations (Scopus)

Autonomic system and amyotrophic lateral sclerosis

Piccione, E. A., Sletten, D. M., Staff, N. P. & Low, P. A., May 1 2015, In : Muscle and Nerve. 51, 5, p. 676-679 4 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Motor Neurons
Motor Neuron Disease
Autonomic Pathways
Pyramidal Tracts
20 Citations (Scopus)

Candidate pathway-based genetic association study of platinum and platinum-taxane related toxicity in a cohort of primary lung cancer patients

Johnson, C., Pankratz, V. S., Velazquez, A. I., Aakre, J. A., Loprinzi, C. L., Staff, N. P., Windebank, A. J. & Yang, P., Feb 15 2015, In : Journal of the Neurological Sciences. 349, 1-2, p. 124-128 5 p.

Research output: Contribution to journalArticle

Genetic Association Studies
Platinum
Lung Neoplasms
Peripheral Nervous System Diseases
Drug Therapy
77 Citations (Scopus)

Clinical course of oxaliplatin-induced neuropathy: Results from the randomized phase III trial N08CB (Alliance)

Pachman, D. R., Qin, R., Seisler, D. K., Smith, E. M. L., Beutler, A. S., Ta, L. E., Lafky, J. M., Wagner-Johnston, N. D., Ruddy, K. J., Dakhil, S., Staff, N. P., Grothey, A. F. & Loprinzi, C. L., Oct 20 2015, In : Journal of Clinical Oncology. 33, 30, p. 3416-3422 7 p.

Research output: Contribution to journalArticle

oxaliplatin
Drug Therapy
Foot
Hand
Muscle Cramp
36 Citations (Scopus)

Impairments and comorbidities of polyneuropathy revealed by population-based analyses

Hoffman, E. M., Staff, N. P., Robb, J. M., St. Sauver, J., Dyck, P. J. & Klein, C. J., Apr 21 2015, In : Neurology. 84, 16, p. 1644-1651 8 p.

Research output: Contribution to journalArticle

Polyneuropathies
Comorbidity
Odds Ratio
Diabetic Neuropathies
Population
16 Citations (Scopus)
Amyotrophic Lateral Sclerosis
Peripheral Nerves
Magnetic Resonance Imaging
Muscles
Muscular Atrophy
9 Citations (Scopus)

Neuropathies after surgery: Anatomical considerations of pathologic mechanisms

Johnson, R. L., Warner, M. E., Staff, N. P. & Warner, M. A., Jul 1 2015, In : Clinical Anatomy. 28, 5, p. 678-682 5 p.

Research output: Contribution to journalArticle

Wounds and Injuries
Nerve Tissue
Divorce
Upper Extremity
Lower Extremity
2014
7 Citations (Scopus)

Breaking down translation barriers: Investigator's perspective

Staff, N. P., Runge, B. K. & Windebank, A. J., Sep 3 2014, In : Science Translational Medicine. 6, 252, 252cm7.

Research output: Contribution to journalArticle

Research Personnel
14 Citations (Scopus)

Chronic meralgia paresthetica and neurectomy: A clinical pathologic study

Berini, S. E., Spinner, R. J., Jentoft, M. E., Engelstad, J. K., Staff, N. P., Suanprasert, N., Dyck, P. J. B. & Klein, C. J., Apr 29 2014, In : Neurology. 82, 17, p. 1551-1555 5 p.

Research output: Contribution to journalArticle

Femoral Nerve
Skin
Intractable Pain
Groin
Ligaments
14 Citations (Scopus)

Ipsilateral inflammatory neuropathy after hip surgery

Laughlin, R. S., Dyck, P. J. B., Watson, J., Spinner, R. J., Amrami, K. K., Sierra, R. J., Trousdale, R. T. & Staff, N. P., 2014, In : Mayo Clinic Proceedings. 89, 4, p. 454-461 8 p.

Research output: Contribution to journalArticle

Hip
Biopsy
Pain
Mechanical Phenomena
Methylprednisolone
18 Citations (Scopus)

Peripheral neuropathy due to vitamin deficiency, toxins, and medications

Staff, N. P. & Windebank, A. J., Oct 1 2014, In : Continuum (Minneapolis, Minn.). 20, 5 Peripheral Nervous System Disorders, p. 1293-1306 14 p.

Research output: Contribution to journalArticle

Avitaminosis
Peripheral Nervous System Diseases
Peripheral Nerves
2 Citations (Scopus)
Respiratory Paralysis
Phrenic Nerve
Nerve Block
Diaphragm
Paralysis
2013
12 Citations (Scopus)

An automated climbing apparatus to measure chemotherapy-induced neurotoxicity in Drosophila melanogaster

Podratz, J. L., Staff, N. P., Boesche, J. B., Giorno, N. J., Hainy, M. E., Herring, S. A., Klennert, M. T., Milaster, C., Nowakowski, S. E., Krug, R. G., Peng, Y. & Windebank, A. J., 2013, In : Fly. 7, 3

Research output: Contribution to journalArticle

neurotoxicity
drug therapy
Drosophila melanogaster
assays
automation
32 Citations (Scopus)

Assessing decreased sensation and increased sensory phenomena in diabetic polyneuropathies

Dyck, P. J., Herrmann, D. N., Staff, N. P. & Dyck, P. J. B., Nov 2013, In : Diabetes. 62, 11, p. 3677-3686 10 p.

Research output: Contribution to journalArticle

Diabetic Neuropathies
Hyperalgesia
Neurogenic Arthropathy
Foot Ulcer
Neural Conduction
45 Citations (Scopus)

Bortezomib alters microtubule polymerization and axonal transport in rat dorsal root ganglion neurons

Staff, N. P., Podratz, J. L., Grassner, L., Bader, M., Paz, J., Knight, A. M., Loprinzi, C. L., Trushina, E. D. & Windebank, A. J., Dec 2013, In : NeuroToxicology. 39, p. 124-131 8 p.

Research output: Contribution to journalArticle

Axonal Transport
Spinal Ganglia
Microtubules
Polymerization
Neurons
2012
12 Citations (Scopus)

A case of peripheral nerve microvasculitis associated with multiple myeloma and bortezomib treatment

Mauermann, M. M., Blumenreich, M. S., Dispenzieri, A. & Staff, N. P., Dec 2012, In : Muscle and Nerve. 46, 6, p. 970-977 8 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Peripheral Nerves
Polyradiculoneuropathy
Peripheral Nervous System Diseases
Therapeutics
51 Citations (Scopus)
Diabetic Neuropathies
Wounds and Injuries
Brachial Plexus
Inflammation
Pain
18 Citations (Scopus)

MRI and PET imaging discordance in neurosarcoidosis

Huang, J. F., Aksamit, A. J. & Staff, N. P., Sep 4 2012, In : Neurology. 79, 10, p. 1070 1 p.

Research output: Contribution to journalArticle

Neurosarcoidosis
2011
143 Citations (Scopus)

Cisplatin induced Mitochondrial DNA damage in dorsal root ganglion neurons

Podratz, J. L., Knight, A. M., Ta, L. E., Staff, N. P., Gass, J. M., Genelin, K., Schlattau, A., Lathroum, L. & Windebank, A. J., Mar 2011, In : Neurobiology of Disease. 41, 3, p. 661-668 8 p.

Research output: Contribution to journalArticle

Spinal Ganglia
Mitochondrial DNA
Cisplatin
DNA Damage
Neurons
23 Citations (Scopus)

Drosophila melanogaster: A new model to study cisplatin-induced neurotoxicity

Podratz, J. L., Staff, N. P., Froemel, D., Wallner, A., Wabnig, F., Bieber, A. J., Tang, A. & Windebank, A. J., Aug 2011, In : Neurobiology of Disease. 43, 2, p. 330-337 8 p.

Research output: Contribution to journalArticle

Drosophila melanogaster
Cisplatin
Diptera
Apoptosis
Drosophila
7 Citations (Scopus)

Neuronal intracellular transport and neurodegenerative disease

Staff, N. P., Benarroch, E. E. & Klein, C. J., Mar 15 2011, In : Neurology. 76, 11, p. 1015-1020 6 p.

Research output: Contribution to journalArticle

Biological Transport
Neurodegenerative Diseases
Neurons

Reply from the authors

Staff, N. P., Benarroch, E. E. & Klein, C. J., Nov 22 2011, In : Neurology. 77, 21, p. 1932 1 p.

Research output: Contribution to journalArticle

2010
8 Citations (Scopus)

Hypertrophic nerves producing myelopathy in fulminant CIDP.

Staff, N. P., Figueroa, J. J., Parisi, J. E. & Klein, C. J., Aug 24 2010, In : Neurology. 75, 8, p. 750 1 p.

Research output: Contribution to journalArticle

Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Spinal Cord Compression
Fatal Outcome
Spinal Nerve Roots
Spinal Cord Diseases
3 Citations (Scopus)

Metastatic lobular breast adenocarcinoma presenting as cauda equina syndrome

Staff, N. P., Bosch, E. P., Engelstad, J., Moynihan, T. J., Spinner, R. J. & Dyck, P. J. B., Mar 2010, In : Journal of the Peripheral Nervous System. 15, 1, p. 75-78 4 p.

Research output: Contribution to journalArticle

Meningeal Neoplasms
Peripheral Nervous System Neoplasms
Polyradiculopathy
Spinal Nerves
Adenocarcinoma
121 Citations (Scopus)

Post-surgical inflammatory neuropathy

Staff, N. P., Engelstad, J., Klein, C. J., Amrami, K. K., Spinner, R. J., Dyck, P. J., Warner, M. A., Warner, M. E. & Dyck, P. J. B., 2010, In : Brain. 133, 10, p. 2866-2880 15 p.

Research output: Contribution to journalArticle

Biopsy
Immunotherapy
Electrophysiology
Inflammation
Peripheral Nerves
2009
54 Citations (Scopus)

Multiple sclerosis with predominant, severe cognitive impairment

Staff, N. P., Lucchinetti, C. F. & Keegan, B. M., Sep 2009, In : Archives of Neurology. 66, 9, p. 1139-1143 5 p.

Research output: Contribution to journalArticle

Multiple Sclerosis
Tobacco Products
Psychiatry
Magnetic Resonance Imaging
Demography
2006
9 Citations (Scopus)

Form and function of ON-OFF amacrine cells in the amphibian retina

Miller, R. F., Staff, N. P. & Velte, T. J., May 2006, In : Journal of Neurophysiology. 95, 5, p. 3171-3190 20 p.

Research output: Contribution to journalArticle

Amacrine Cells
Amphibians
Retina
Ambystoma
Computer Simulation
2003
47 Citations (Scopus)

Intracellular correlate of EPSP-Spike potentiation in CA1 pyramidal neurons is controlled by GABAergic modulation

Staff, N. P. & Spruston, N., 2003, In : Hippocampus. 13, 7, p. 801-805 5 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Excitatory Postsynaptic Potentials
Action Potentials
Hippocampus
Aminobutyrates
30 Citations (Scopus)

Psychostimulant-Induced Plasticity of Intrinsic Neuronal Excitability in Ventral Subiculum

Cooper, D. C., Moore, S. J., Staff, N. P. & Spruston, N., Oct 29 2003, In : Journal of Neuroscience. 23, 30, p. 9937-9946 10 p.

Research output: Contribution to journalArticle

Neuronal Plasticity
Amphetamine
Hippocampus
Dopamine
Sodium Channels
2002
384 Citations (Scopus)

Dendritic spikes as a mechanism for cooperative long-term potentiation

Golding, N. L., Staff, N. P. & Spruston, N., Jul 18 2002, In : Nature. 418, 6895, p. 326-331 6 p.

Research output: Contribution to journalArticle

Long-Term Potentiation
Action Potentials
Synapses
Axons
Synaptic Potentials
2001
80 Citations (Scopus)

Action potential bursting in subicular pyramidal neurons is driven by a calcium tail current

Jung, H. Y., Staff, N. P. & Spruston, N., May 15 2001, In : Journal of Neuroscience. 21, 10, p. 3312-3321 10 p.

Research output: Contribution to journalArticle

Pyramidal Cells
Action Potentials
Calcium
Hippocampus
Neuronal Plasticity
10 Citations (Scopus)

Structure and functional connections of presynaptic terminals in the vertebrate retina revealed by activity-dependent dyes and confocal microscopy

Miller, R. F., Fagerson, M. H., Staff, N. P., Wolfe, R., Doerr, T., Gottesman, J., Sikora, M. A. & Schuneman, R., Aug 20 2001, In : Journal of Comparative Neurology. 437, 2, p. 129-155 27 p.

Research output: Contribution to journalArticle

Presynaptic Terminals
Confocal Microscopy
Vertebrates
Retina
Coloring Agents