• 8080 Citations
  • 45 Scopus h-Index
20022021
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Research Output 2002 2019

  • 8080 Citations
  • 45 Scopus h-Index
  • 93 Article
  • 3 Review article
  • 1 Chapter
  • 1 Editorial
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Article
2019
2 Citations (Scopus)

Frailty and clinical outcomes in chronic obstructive pulmonary disease

NETT Research Group, Feb 1 2019, In : Annals of the American Thoracic Society. 16, 2, p. 217-224 8 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Confidence Intervals
Emphysema
Forced Expiratory Volume
Phenotype
Open Access
Gait
Health
5 Citations (Scopus)

Hyperoxia-induced cellular senescence in fetal airway smooth muscle cells

Parikh, P., Britt, R. J., Manlove, L. J., Wicher, S. A., Roesler, A., Ravix, J., Teske, J., Thompson, M. A., Sieck, G. C., Kirkland, J. L., LeBrasseur, N. K., Tschumperlin, D. J., Pabelick, C. M. & Prakash, Y. S., Jan 1 2019, In : American journal of respiratory cell and molecular biology. 61, 1, p. 51-60 10 p.

Research output: Contribution to journalArticle

Hyperoxia
Cell Aging
Smooth Muscle Myocytes
Muscle
Cells

Late-life time-restricted feeding and exercise differentially alter healthspan in obesity

Schafer, M. J., Mazula, D. L., Brown, A. K., White, T. A., Atkinson, E., Pearsall, V. M., Aversa, Z., Verzosa, G. C., Smith, L. A., Matveyenko, A. V., Miller, J. D. & LeBrasseur, N. K., Aug 1 2019, In : Aging Cell. 18, 4, e12966.

Research output: Contribution to journalArticle

Open Access
Obesity
Activities of Daily Living
Body Composition
Pathology
Health Priorities
19 Citations (Scopus)

Length-independent telomere damage drives post-mitotic cardiomyocyte senescence

Anderson, R., Lagnado, A., Maggiorani, D., Walaszczyk, A., Dookun, E., Chapman, J., Birch, J., Salmonowicz, H., Ogrodnik, M., Jurk, D., Proctor, C., Correia-Melo, C., Victorelli, S., Fielder, E., Berlinguer-Palmini, R., Owens, A., Greaves, L. C., Kolsky, K. L., Parini, A., Douin-Echinard, V. & 14 others, LeBrasseur, N. K., Arthur, H. M., Tual-Chalot, S., Schafer, M. J., Roos, C. M., Miller, J. D., Robertson, N., Mann, J., Adams, P. D., Tchkonia, T., Kirkland, J. L., Mialet-Perez, J., Richardson, G. D. & Passos, J., Mar 1 2019, In : EMBO Journal. 38, 5, e100492.

Research output: Contribution to journalArticle

Open Access
Telomere
Cardiac Myocytes
Aging of materials
Telomere Shortening
Phenotype

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. T. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T. J., Passos, J. F. & 13 others, Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T. & Kirkland, J. L., Sep 2019, In : EBioMedicine. 47, p. 446-456 11 p.

Research output: Contribution to journalArticle

Open Access
Quercetin
Diabetic Nephropathies
Clinical Trials
Macrophages
Tissue
53 Citations (Scopus)

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

Justice, J. N., Nambiar, A. M., Tchkonia, T., LeBrasseur, N. K., Pascual, R., Hashmi, S. K., Prata, L., Masternak, M. M., Kritchevsky, S. B., Musi, N. & Kirkland, J. L., Jan 1 2019, (Accepted/In press) In : EBioMedicine.

Research output: Contribution to journalArticle

Idiopathic Pulmonary Fibrosis
Quercetin
Labels
Cell Aging
Phenotype
12 Citations (Scopus)

Targeting senescent cells alleviates obesity-induced metabolic dysfunction

Palmer, A. K., Xu, M., Zhu, Y., Pirtskhalava, T., Weivoda, M., Hachfeld, C. M., Prata, L. G., van Dijk, T. H., Verkade, E., Casaclang-Verzosa, G., Johnson, K. O., Cubro, H., Doornebal, E. J., Ogrodnik, M., Jurk, D., Jensen, M. D., Chini, E. N., Miller, J. D., Matveyenko, A. V., Stout, M. B. & 13 others, Schafer, M. J., White, T. A., Hickson, L., Demaria, M., Garovic, V. D., Grande, J. P., Arriaga, E. A., Kuipers, F., von Zglinicki, T., LeBrasseur, N. K., Campisi, J., Tchkonia, T. & Kirkland, J. L., Jun 1 2019, In : Aging Cell. 18, 3, e12950.

Research output: Contribution to journalArticle

Open Access
Obesity
Adipose Tissue
Obese Mice
Insulin Resistance
p16 Genes

TFAM enhances fat oxidation and attenuates high-fat diet-induced insulin resistance in skeletal muscle

Koh, J. H., Johnson, M. L., Dasari, S., LeBrasseur, N. K., Vuckovic, I., Henderson, G. C., Cooper, S. A., Manjunatha, S., Ruegsegger, G. N., Shulman, G. I., Lanza, I. R. & Nair, K. S., Aug 1 2019, In : Diabetes. 68, 8, p. 1552-1564 13 p.

Research output: Contribution to journalArticle

High Fat Diet
Insulin Resistance
Skeletal Muscle
Fats
Muscles
1 Citation (Scopus)

The clinical impact and biological mechanisms of skeletal muscle aging

Aversa, Z., Zhang, X., Fielding, R. A., Lanza, I. R. & LeBrasseur, N. K., Oct 1 2019, In : Bone. 127, p. 26-36 11 p.

Research output: Contribution to journalArticle

Sarcopenia
Skeletal Muscle
Muscles
Muscular Atrophy
Cell Aging
2 Citations (Scopus)

The Relationship Between Frailty and Decreased Physical Performance With Death on the Kidney Transplant Waiting List

Lorenz, E. C., Cosio, F. G., Bernard, S. L., Bogard, S. D., Bjerke, B. R., Geissler, E. N., Hanna, S. W., Kremers, W. K., Cheng, Y., Stegall, M. D., Cheville, A. L. & LeBrasseur, N. K., Jan 1 2019, In : Progress in Transplantation.

Research output: Contribution to journalArticle

Waiting Lists
Transplants
Kidney
Dialysis
Confidence Intervals
2018
14 Citations (Scopus)

Cellular Senescence Biomarker p16 INK4a + Cell Burden in Thigh Adipose is Associated with Poor Physical Function in Older Women

Justice, J. N., Gregory, H., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Kritchevsky, S. B. & Nicklas, B. J., Jun 14 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 7, p. 939-945 7 p.

Research output: Contribution to journalArticle

Cell Aging
Thigh
Biomarkers
Caloric Restriction
Resistance Training
12 Citations (Scopus)

Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans

Yousefzadeh, M. J., Schafer, M. J., Noren Hooten, N., Atkinson, E. J., Evans, M. K., Baker, D. J., Quarles, E. K., Robbins, P. D., Ladiges, W. C., LeBrasseur, N. K. & Niedernhofer, L. J., Jan 1 2018, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

Chemokine CCL2
Biomarkers
Progeria
Genetic Engineering
Aortic Valve Stenosis
6 Citations (Scopus)

Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging

Rocca, W. A., Gazzuola Rocca, L., Smith, C. Y., Grossardt, B. R., Faubion, S. S., Shuster, L. T., Kirkland, J. L., LeBrasseur, N. K., Schafer, M. J., Mielke, M. M., Kantarci, K. M., Stewart, E. A. & Miller, V. M., Nov 1 2018, In : Physiology (Bethesda, Md.). 33, 6, p. 374-383 10 p.

Research output: Contribution to journalArticle

Ovariectomy
Hormones
Comorbidity
Estrogens
Survival
4 Citations (Scopus)

Plasma Sphingolipids are Associated with Gait Parameters in the Mayo Clinic Study of Aging

Wennberg, A. M. V., Schafer, M. J., LeBrasseur, N. K., Savica, R., Bui, H. H., Hagen, C. E., Hollman, J. H., Petersen, R. C. & Mielke, M. M., Jun 14 2018, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 73, 7, p. 960-965 6 p.

Research output: Contribution to journalArticle

Sphingolipids
Gait
Ceramides
Linear Models
Proteolysis
162 Citations (Scopus)

Senolytics improve physical function and increase lifespan in old age

Xu, M., Pirtskhalava, T., Farr, J., Weigand, B. M., Palmer, A. K., Weivoda, M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., Verzosa, G. C., Langhi, L. G. P., Weigl, M., Giorgadze, N., LeBrasseur, N. K., Miller, J. D., Jurk, D., Singh, R. J. & 13 others, Allison, D. B., Ejima, K., Hubbard, G. B., Ikeno, Y., Cubro, H., Garovic, V. D., Hou, X., Weroha, S. J., Robbins, P. D., Niedernhofer, L. J., Khosla, S., Tchkonia, T. & Kirkland, J. L., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1246-1256 11 p.

Research output: Contribution to journalArticle

Health
Tissue
Cell Aging
Quercetin
Pathology
2017
26 Citations (Scopus)

17α-estradiol alleviates age-related metabolic and inflammatory dysfunction in male mice without inducing feminization

Stout, M. B., Steyn, F. J., Jurczak, M. J., Camporez, J. P. G., Zhu, Y., Hawse, J. R., Jurk, D., Palmer, A. K., Xu, M., Pirtskhalava, T., Evans, G. L., De Souza Santos, R., Frank, A. P., White, T. A., Monroe, D. G., Singh, R. J., Casaclang-Verzosa, G., Miller, J. D., Clegg, D. J., LeBrasseur, N. K. & 4 others, Von Zglinicki, T., Shulman, G. I., Tchkonia, T. & Kirkland, J. L., 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 1, p. 3-15 13 p.

Research output: Contribution to journalArticle

Feminization
Intra-Abdominal Fat
Estradiol
Adiposity
Glucose
14 Citations (Scopus)
Longitudinal Studies
Liver
Insulin Resistance
Diet
Fast Foods
214 Citations (Scopus)

Cellular senescence mediates fibrotic pulmonary disease

Schafer, M. J., White, T. A., Iijima, K., Haak, A. J., Ligresti, G., Atkinson, E. J., Oberg, A. L., Birch, J., Salmonowicz, H., Zhu, Y., Mazula, D. L., Brooks, R. W., Fuhrmann-Stroissnigg, H., Pirtskhalava, T., Prakash, Y. S., Tchkonia, T., Robbins, P. D., Aubry, M. C., Passos, J., Kirkland, J. L. & 3 others, Tschumperlin, D. J., Kita, H. & LeBrasseur, N. K., Feb 23 2017, In : Nature Communications. 8, 14532.

Research output: Contribution to journalArticle

fibrosis
Pulmonary diseases
Cell Aging
Idiopathic Pulmonary Fibrosis
Lung Diseases
13 Citations (Scopus)

Functional not chronologic age: Frailty index predicts outcomes in advanced ovarian cancer

Kumar, A., Langstraat, C. L., DeJong, S. R., McGree, M. E., Bakkum-Gamez, J. N., Weaver, A. L., LeBrasseur, N. K. & Cliby, W. A., 2017, (Accepted/In press) In : Gynecologic Oncology.

Research output: Contribution to journalArticle

Ovarian Neoplasms
Odds Ratio
Survival
Ambulatory Surgical Procedures
Medical Records
8 Citations (Scopus)

Relationship between pre-transplant physical function and outcomes after kidney transplant

Lorenz, E. C., Cheville, A. L., Amer, H., Kotajarvi, B. R., Stegall, M. D., Petterson, T. M., Kremers, W. K., Cosio, F. G. & LeBrasseur, N. K., May 1 2017, In : Clinical Transplantation. 31, 5, e12952.

Research output: Contribution to journalArticle

Transplants
Kidney
Length of Stay
Quality of Life
Living Donors
135 Citations (Scopus)

Targeting cellular senescence prevents age-related bone loss in mice

Farr, J., Xu, M., Weivoda, M., Monroe, D. G., Fraser, D. G., Onken, J. L., Negley, B. A., Sfeir, J. G., Ogrodnik, M. B., Hachfeld, C. M., LeBrasseur, N. K., Drake, M. M., Pignolo, R., Pirtskhalava, T., Tchkonia, T., Oursler, M. J., Kirkland, J. L. & Khosla, S., Sep 1 2017, In : Nature Medicine. 23, 9, p. 1072-1079 8 p.

Research output: Contribution to journalArticle

Cell Aging
Osteoporosis
Bone
Bone and Bones
Caspase 8
13 Citations (Scopus)

The Impact of Frailty on Patient-Centered Outcomes Following Aortic Valve Replacement

Kotajarvi, B. R., Schafer, M. J., Atkinson, E. J., Traynor, M. M., Bruce, C. J., Greason, K. L., Suri, R. M., Miller, J. D. & LeBrasseur, N. K., Jul 1 2017, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 72, 7, p. 917-921 5 p.

Research output: Contribution to journalArticle

Aortic Valve
Quality of Life
Aortic Valve Stenosis
Health
Mental Health
2016
8 Citations (Scopus)

Cellular senescence: Implications for metabolic disease

Schafer, M. J., Miller, J. D. & LeBrasseur, N. K., May 4 2016, (Accepted/In press) In : Molecular and Cellular Endocrinology.

Research output: Contribution to journalArticle

Cell Aging
Metabolic Diseases
Aging of materials
Tissue
Obesity
28 Citations (Scopus)

CXCL10-Mediates Macrophage, but not Other Innate Immune Cells-Associated Inflammation in Murine Nonalcoholic Steatohepatitis

Tomita, K., Freeman, B. L., Bronk, S. F., LeBrasseur, N. K., White, T. A., Hirsova, P. & Ibrahim, S. C., Jun 28 2016, In : Scientific Reports. 6, 28786.

Research output: Contribution to journalArticle

Macrophages
Inflammation
Fructose
Liver
Fats
25 Citations (Scopus)

Disease drivers of aging

Hodes, R. J., Sierra, F., Austad, S. N., Epel, E., Neigh, G. N., Erlandson, K. M., Schafer, M. J., LeBrasseur, N. K., Wiley, C., Campisi, J., Sehl, M. E., Scalia, R., Eguchi, S., Kasinath, B. S., Halter, J. B., Cohen, H. J., Demark-Wahnefried, W., Ahles, T. A., Barzilai, N., Hurria, A. & 1 others, Hunt, P. W., Dec 1 2016, In : Annals of the New York Academy of Sciences. 1386, 1, p. 45-68 24 p.

Research output: Contribution to journalArticle

Chronic Disease
Aging of materials
Acquired Immunodeficiency Syndrome
Pathology
Medical problems
19 Citations (Scopus)

Energetic interventions for healthspan and resiliency with aging

Huffman, D. M., Schafer, M. J. & LeBrasseur, N. K., Dec 15 2016, In : Experimental Gerontology. 86, p. 73-83 11 p.

Research output: Contribution to journalArticle

Caloric Restriction
Aging of materials
Health
Bed Rest
Metformin
61 Citations (Scopus)

Exercise prevents diet-induced cellular senescence in adipose tissue

Schafer, M. J., White, T. A., Evans, G., Tonne, J. M., Verzosa, G. C., Stout, M. B., Mazula, D. L., Palmer, A. K., Baker, D. J., Jensen, M. D., Torbenson, M., Miller, J. D., Ikeda, Y. H., Tchkonia, T., Van Deursen, J., Kirkland, J. L. & LeBrasseur, N. K., Jun 1 2016, In : Diabetes. 65, 6, p. 1606-1615 10 p.

Research output: Contribution to journalArticle

Cell Aging
Fast Foods
Adipose Tissue
Diet
Intra-Abdominal Fat
12 Citations (Scopus)

High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver

Zhou, D., Hlady, R. A., Schafer, M. J., White, T. A., Liu, C., Choi, J. H., Miller, J. D., Roberts, L. R., LeBrasseur, N. K. & Robertson, K. D., Dec 22 2016, (Accepted/In press) In : Epigenetics. p. 1-15 15 p.

Research output: Contribution to journalArticle

High Fat Diet
Diet
Liver
DNA
DNA Methylation
67 Citations (Scopus)

Identification of Senescent Cells in the Bone Microenvironment

Farr, J., Fraser, D. G., Wang, H., Jaehn, K., Ogrodnik, M. B., Weivoda, M., Drake, M. M., Tchkonia, T., LeBrasseur, N. K., Kirkland, J. L., Bonewald, L. F., Pignolo, R., Monroe, D. G. & Khosla, S., Nov 1 2016, In : Journal of Bone and Mineral Research. 31, 11, p. 1920-1929 10 p.

Research output: Contribution to journalArticle

Osteocytes
Bone and Bones
Phenotype
Satellite DNA
Cell Aging
77 Citations (Scopus)

Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease

Schafer, M. J., Atkinson, E. J., Vanderboom, P. M., Kotajarvi, B., White, T. A., Moore, M. M., Bruce, C. J., Greason, K. L., Suri, R. M., Khosla, S., Miller, J. D., Bergen, H. R. B. III. & LeBrasseur, N. K., Jun 14 2016, In : Cell Metabolism. 23, 6, p. 1207-1215 9 p.

Research output: Contribution to journalArticle

Growth Differentiation Factors
Myostatin
Cardiovascular Diseases
Aortic Valve Stenosis
Transforming Growth Factors
2015
41 Citations (Scopus)

Cellular Senescence and the Biology of Aging, Disease, and Frailty

LeBrasseur, N. K., Tchkonia, T. & Kirkland, J. L., 2015, In : Nestle Nutrition Institute Workshop Series. 83, p. 11-18 8 p.

Research output: Contribution to journalArticle

Cell Aging
Cell Biology
Biological Sciences
Phenotype
phenotype
91 Citations (Scopus)

Cellular senescence in type 2 diabetes: A therapeutic opportunity

Palmer, A. K., Tchkonia, T., LeBrasseur, N. K., Chini, E. N., Xu, M. & Kirkland, J. L., Jul 1 2015, In : Diabetes. 64, 7, p. 2289-2298 10 p.

Research output: Contribution to journalArticle

Cell Aging
Type 2 Diabetes Mellitus
Diabetes Complications
Phenotype
Therapeutics
6 Citations (Scopus)

Conditional deletion of Hdac3 in osteoprogenitor cells attenuates diet-induced systemic metabolic dysfunction

McGee-Lawrence, M. E., White, T. A., LeBrasseur, N. K. & Westendorf, J. J., Jul 5 2015, In : Molecular and Cellular Endocrinology. 410, p. 42-51 10 p.

Research output: Contribution to journalArticle

Osteocalcin
High Fat Diet
Nutrition
Osteoblasts
Skeleton
159 Citations (Scopus)

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

Xu, M., Tchkonia, T., Ding, H., Ogrodnik, M., Lubbers, E. R., Pirtskhalava, T., White, T. A., Johnson, K. O., Stout, M. B., Mezera, V., Giorgadze, N., Jensen, M. D., LeBrasseur, N. K. & Kirkland, J. L., Nov 17 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 46, p. E6301-E6310

Research output: Contribution to journalArticle

Cell Aging
Conditioned Culture Medium
Inflammation
Phenotype
Adipose Tissue
34 Citations (Scopus)
Myostatin
Sarcopenia
Mass Spectrometry
Muscles
Follistatin-Related Proteins
75 Citations (Scopus)

Shear wave elastography of passive skeletal muscle stiffness: Influences of sex and age throughout adulthood

Eby, S. F., Cloud, B. A., Brandenburg, J. E., Giambini, H., Song, P., Chen, S. D., LeBrasseur, N. K. & An, K. N., Jan 1 2015, In : Clinical Biomechanics. 30, 1, p. 22-27 6 p.

Research output: Contribution to journalArticle

Elasticity Imaging Techniques
Skeletal Muscle
Tendons
Muscles
Elbow
126 Citations (Scopus)

Targeting senescent cells enhances adipogenesis and metabolic function in old age

Xu, M., Palmer, A. K., Ding, H., Weivoda, M., Pirtskhalava, T., White, T. A., Sepe, A., Johnson, K. O., Stout, M. B., Giorgadze, N., Jensen, M. D., LeBrasseur, N. K., Tchkonia, T. & Kirkland, J. L., Dec 19 2015, In : eLife. 4, DECEMBER2015, e12997.

Research output: Contribution to journalArticle

Adipogenesis
Fats
Aging of materials
Tissue
Lipodystrophy
404 Citations (Scopus)

The Achilles' heel of senescent cells: From transcriptome to senolytic drugs

Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O'Hara, S. P., La Russo, N. F., Miller, J. D., Roos, C. M., Verzosa, G. C., LeBrasseur, N. K., Wren, J. D., Farr, J., Khosla, S., Stout, M. B. & 13 others, Mcgowan, S. J., Fuhrmann-Stroissnigg, H., Gurkar, A. U., Zhao, J., Colangelo, D., Dorronsoro, A., Ling, Y. Y., Barghouthy, A. S., Navarro, D. C., Sano, T., Robbins, P. D., Niedernhofer, L. J. & Kirkland, J. L., 2015, (Accepted/In press) In : Aging Cell.

Research output: Contribution to journalArticle

Transcriptome
Pharmaceutical Preparations
Quercetin
Transgenic Suicide Genes
Ephrins
36 Citations (Scopus)

TRAIL receptor deletion in mice suppresses the inflammation of nutrient excess

Idrissova, L., Malhi, H. M., Werneburg, N. W., LeBrasseur, N. K., Bronk, S. F., Fingas, C., Tchkonia, T., Pirtskhalava, T., White, T. A., Stout, M. B., Hirsova, P., Krishnan, A., Liedtke, C., Trautwein, C., Finnberg, N., El-Deiry, W. S., Kirkland, J. L. & Gores, G. J., May 1 2015, In : Journal of Hepatology. 62, 5, p. 1156-1163 8 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand Receptors
Inflammation
Food
Liver
Adipose Tissue
2014
19 Citations (Scopus)

Body composition during childhood and adolescence: Relations to bone strength and microstructure

Farr, J., Amin, S., LeBrasseur, N. K., Atkinson, E. J., Achenbach, S. J., McCready, L. K., Melton, L. J. & Khosla, S., Dec 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 12, p. 4641-4648 8 p.

Research output: Contribution to journalArticle

Body Composition
Bone
Bone and Bones
Microstructure
Fats
25 Citations (Scopus)

Determinants of gait speed in COPD

Karpman, C., DePew, Z. S., LeBrasseur, N. K., Novotny, P. J. & Benzo, R. P., 2014, In : Chest. 146, 1, p. 104-110 7 p.

Research output: Contribution to journalArticle

Chronic Obstructive Pulmonary Disease
Exercise
Patient Care
Cognition
Walking Speed
33 Citations (Scopus)

Glycolytic fast-twitch muscle fiber restoration counters adverse age-related changes in body composition and metabolism

Akasaki, Y., Ouchi, N., Izumiya, Y., Bernardo, B. L., LeBrasseur, N. K. & Walsh, K., Feb 2014, In : Aging Cell. 13, 1, p. 80-91 12 p.

Research output: Contribution to journalArticle

Fast-Twitch Muscle Fibers
Body Composition
Muscles
Skeletal Muscle
Fat-Restricted Diet
53 Citations (Scopus)

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice

Stout, M. B., Tchkonia, T., Pirtskhalava, T., Palmer, A. K., List, E. O., Berryman, D. E., Lubbers, E. R., Escande, C., Spong, A., Masternak, M. M., Oberg, A. L., LeBrasseur, N. K., Miller, R. A., Kopchick, J. J., Bartke, A. & Kirkland, J. L., 2014, In : Aging. 6, 7, p. 575-586 12 p.

Research output: Contribution to journalArticle

White Adipose Tissue
Growth Hormone
Adipogenesis
Cell Aging
Adiposity
54 Citations (Scopus)

Liver-Specific gh receptor gene-Disrupted (lighrko) mice have decreased endocrine igf-I, increased local igf-I, and altered body size, body composition, and adipokine profiles

List, E. O., Berryman, D. E., Funk, K., Jara, A., Kelder, B., Wang, F., Stout, M. B., Zhi, X., Sun, L., White, T. A., LeBrasseur, N. K., Pirtskhalava, T., Tchkonia, T., Jensen, E. A., Zhang, W., Masternak, M. M., Kirkland, J. L., Miller, R. A., Bartke, A. & Kopchick, J. J., 2014, In : Endocrinology. 155, 5, p. 1793-1805 13 p.

Research output: Contribution to journalArticle

Adipokines
Body Size
Body Composition
Insulin-Like Growth Factor I
Liver
29 Citations (Scopus)

Measuring gait speed in the out-patient clinic: Methodology and feasibility

Karpman, C., LeBrasseur, N. K., De Pew, Z. S., Novotny, P. J. & Benzo, R. P., 2014, In : Respiratory Care. 59, 4, p. 531-537 7 p.

Research output: Contribution to journalArticle

Outpatients
Chronic Obstructive Pulmonary Disease
Walking Speed
Vital Signs
Ambulatory Care
57 Citations (Scopus)

Myostatin and sarcopenia: Opportunities and challenges - A mini-review

White, T. A. & LeBrasseur, N. K., 2014, In : Gerontology. 60, 4, p. 289-293 5 p.

Research output: Contribution to journalArticle

Myostatin
Sarcopenia
Skeletal Muscle
Muscle Strength
Quality of Life
19 Citations (Scopus)

Physiologic and metabolic safety of butyrylcholinesterase gene therapy in mice

Murthy, V., Gao, Y., Geng, L., LeBrasseur, N. K., White, T. A., Parks, R. J. & Brimijoin, W. S., Jul 16 2014, In : Vaccine. 32, 33, p. 4155-4162 8 p.

Research output: Contribution to journalArticle

Butyrylcholinesterase
cocaine
gene therapy
cholinesterase
Genetic Therapy
16 Citations (Scopus)

Preclinical studies on neurobehavioral and neuromuscular effects of cocaine hydrolase gene therapy in mice

Murthy, V., Gao, Y., Geng, L., LeBrasseur, N. K., White, T. & Brimijoin, W. S., 2014, In : Journal of Molecular Neuroscience. 53, 3, p. 409-416 8 p.

Research output: Contribution to journalArticle

Neuromuscular Agents
Butyrylcholinesterase
Hydrolases
Cocaine
Genetic Therapy
14 Citations (Scopus)

Regenerating skeletal muscle in the face of aging and disease

Jasuja, R. & LeBrasseur, N. K., 2014, In : American Journal of Physical Medicine and Rehabilitation. 93, 11, p. S88-S96

Research output: Contribution to journalArticle

Skeletal Muscle
Myostatin
Sarcopenia
Physical and Rehabilitation Medicine
Cachexia