• 5958 Citations
  • 43 Scopus h-Index
1992 …2018

Research output per year

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Research Output

  • 5958 Citations
  • 43 Scopus h-Index
  • 81 Article
  • 8 Review article
  • 2 Chapter
  • 1 Comment/debate
2018

Vesicle-associated membrane protein 7-mediated eosinophil degranulation promotes allergic airway inflammation in mice

Willetts, L., Felix, L. C., Jacobsen, E. A., Puttagunta, L., Condjella, R. M., Zellner, K. R., Ochkur, S. I., Kim, J. D., Luo, H., Lee, N. A., Lee, J. J., Moqbel, R. & Lacy, P., Dec 1 2018, In : Communications Biology. 1, 1, 83.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2017

Frontline science: Eosinophil-deficient MBP-1 and EPX double-knockout mice link pulmonary remodeling and airway dysfunction with type 2 inflammation

Ochkur, S. I., Doyle, A. D., Jacobsen, E., LeSuer, W. E., Li, W., Protheroe, C. A., Zellner, K. R., Colbert, D., Shen, H. H. H., Irvin, C. G., Lee, J. J. & Lee, N. A., Sep 1 2017, In : Journal of Leukocyte Biology. 102, 3, p. 589-599 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Lung pathologies in a chronic inflammation mouse model are independent of eosinophil degranulation

Jacobsen, E. A., Ochkur, S. I., Doyle, A. D., LeSuer, W. E., Li, W., Protheroe, C. A., Colbert, D., Zellner, K. R., Shen, H. H., Irvin, C. G., Lee, J. J. & Lee, N. A., May 15 2017, In : American journal of respiratory and critical care medicine. 195, 10, p. 1321-1332 12 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

Eosinophil peroxidase catalyzed protein carbamylation participates in asthma

Wang, Z., DiDonato, J. A., Buffa, J., Comhair, S. A., Aronica, M. A., Dweik, R. A., Lee, N. A., Lee, J. J., Thomassen, M. J., Kavuru, M., Erzurum, S. C. & Hazen, S. L., Oct 14 2016, In : Journal of Biological Chemistry. 291, 42, p. 22118-22135 18 p.

Research output: Contribution to journalArticle

13 Scopus citations

Human and mouse eosinophils have antiviral activity against parainfluenza virus

Drake, M. G., Bivins-Smith, E. R., Proskocil, B. J., Nie, Z., Scott, G. D., Lee, J. J., Lee, N. A., Fryer, A. D. & Jacoby, D. B., Sep 1 2016, In : American Journal of Respiratory Cell and Molecular Biology. 55, 3, p. 387-394 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
2015

Differential activation of airway eosinophils induces IL-13-mediated allergic Th2 pulmonary responses in mice

Jacobsen, E., Doyle, A. D., Colbert, D. C., Zellner, K. R., Protheroe, C. A., Lesuer, W. E., Lee, N. A. & Lee, J. J., Sep 1 2015, In : Allergy: European Journal of Allergy and Clinical Immunology. 70, 9, p. 1148-1159 12 p.

Research output: Contribution to journalArticle

28 Scopus citations

Eosinophil-dependent skin innervation and itching following contact toxicant exposure in mice

Lee, J. J., Protheroe, C. A., Luo, H., Ochkur, S. I., Scott, G. D., Zellner, K. R., Raish, R. J., Dahl, M. V., Vega, M. L., Conley, O., Condjella, R. M., Kloeber, J. A., Neely, J. L., Patel, Y. S., Maizer, P., Mazzolini, A., Fryer, A. D., Jacoby, N. W., Jacoby, D. B. & Lee, N. A., Feb 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 2, p. 477-487.e1

Research output: Contribution to journalArticle

15 Scopus citations

Eosinophils and IL-4 Support Nematode Growth Coincident with an Innate Response to Tissue Injury

Huang, L., Beiting, D. P., Gebreselassie, N. G., Gagliardo, L. F., Ruyechan, M. C., Lee, N. A., Lee, J. J. & Appleton, J. A., 2015, In : PLoS pathogens. 11, 12, e1005347.

Research output: Contribution to journalArticle

24 Scopus citations

Eosinophils contribute to the resolution of lung-allergic responses following repeated allergen challenge

Takeda, K., Shiraishi, Y., Ashino, S., Han, J., Jia, Y., Wang, M., Lee, N. A., Lee, J. J. & Gelfand, E. W., Feb 1 2015, In : Journal of Allergy and Clinical Immunology. 135, 2, p. 451-460.e5

Research output: Contribution to journalArticle

18 Scopus citations

Eosinophils mediate protective immunity against secondary nematode infection

Huang, L., Gebreselassie, N. G., Gagliardo, L. F., Ruyechan, M. C., Luber, K. L., Lee, N. A., Lee, J. J. & Appleton, J. A., Jan 1 2015, In : Journal of Immunology. 194, 1, p. 283-290 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Exogenous interleukin-17a inhibits eosinophil differentiation and alleviates allergic airway inflammation

Tian, B. P., Hua, W., Xia, L. X., Jin, Y., Lan, F., Lee, J. J., Lee, N. A., Li, W., Ying, S. M., Chen, Z. H. & Shen, H. H., Apr 1 2015, In : American Journal of Respiratory Cell and Molecular Biology. 52, 4, p. 459-470 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

Nasal and pharyngeal eosinophil peroxidase levels in adults with poorly controlled asthma correlate with sputum eosinophilia

Rank, M. A., Ochkur, S. I., Lewis, J. C., Teaford, H. G., Wesselius, L. J., Helmers, R. A., Lee, N. A., Nair, P. & Lee, J. J., 2015, (Accepted/In press) In : Allergy: European Journal of Allergy and Clinical Immunology.

Research output: Contribution to journalArticle

21 Scopus citations
2014

Activated mouse eosinophils protect against lethal respiratory virus infection

Percopo, C. M., Dyer, K. D., Ochkur, S. I., Luo, J. L., Fischer, E. R., Lee, J. J., Lee, N. A., Domachowske, J. B. & Rosenberg, H. F., Jan 30 2014, In : Blood. 123, 5, p. 743-752 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Changing roles of eosinophils in health and disease

Furuta, G. T., Atkins, F. D., Lee, N. A. & Lee, J. J., Jul 2014, In : Annals of Allergy, Asthma and Immunology. 113, 1, p. 3-8 6 p.

Research output: Contribution to journalArticle

53 Scopus citations

Eosinophil activities modulate the immune/inflammatory character of allergic respiratory responses in mice

Jacobsen, E. A., LeSuer, W. E., Willetts, L., Zellner, K. R., Mazzolini, K., Antonios, N., Beck, B., Protheroe, C., Ochkur, S. I., Colbert, D., Lacy, P., Moqbel, R., Appleton, J., Lee, N. A. & Lee, J. J., Mar 1 2014, In : Allergy: European Journal of Allergy and Clinical Immunology. 69, 3, p. 315-327 13 p.

Research output: Contribution to journalArticle

30 Scopus citations

Eosinophil-derived IL-10 supports chronic nematode infection

Huang, L., Gebreselassie, N. G., Gagliardo, L. F., Ruyechan, M. C., Lee, N. A., Lee, J. J. & Appleton, J. A., Oct 15 2014, In : Journal of Immunology. 193, 8, p. 4178-4187 10 p.

Research output: Contribution to journalArticle

41 Scopus citations

Local hypersensitivity reaction in transgenic mice with squamous epithelial IL-5 overexpression provides a novel model of eosinophilic oesophagitis

Masterson, J. C., McNamee, E. N., Hosford, L., Capocelli, K. E., Ruybal, J., Fillon, S. A., Doyle, A. D., Eltzschig, H. K., Rustgi, A. K., Protheroe, C. A., Lee, N. A., Lee, J. J. & Furuta, G. T., Jan 1 2014, In : Gut. 63, 1, p. 43-53 11 p.

Research output: Contribution to journalArticle

24 Scopus citations

Predicting response to bacillus Calmette-Guérin (BCG) in patients with carcinoma in situ of the bladder

Nunez-Nateras, R., Castle, E. P., Protheroe, C. A., Stanton, M. L., Ocal, T. I., Ferrigni, E. N., Ochkur, S. I., Jacobsen, E. A., Hou, Y. X., Andrews, P. E., Colby, T. V., Lee, N. A. & Lee, J. J., Jan 2014, In : Urologic Oncology: Seminars and Original Investigations. 32, 1, p. 45.e23-45.e30

Research output: Contribution to journalArticle

33 Scopus citations

Re-defining the unique roles for eosinophils in allergic respiratory inflammation

Jacobsen, E. A., Lee, N. A. & Lee, J. J., Sep 2014, In : Clinical and Experimental Allergy. 44, 9, p. 1119-1136 18 p.

Research output: Contribution to journalReview article

43 Scopus citations

Sustained inflammation and differential expression of interferons type I and III in PVM-infected interferon-gamma (IFNγ) gene-deleted mice

Glineur, S. F., Bowen, A. B., Percopo, C. M., Garcia-Crespo, K. E., Dyer, K. D., Ochkur, S. I., Lee, N. A., Lee, J. J., Domachowske, J. B. & Rosenberg, H. F., Nov 2014, In : Virology. 468-470, p. 140-149 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2013

Cys-leukotrienes promote fibrosis in a mouse model of eosinophil-mediated respiratory inflammation

Ochkur, S. I., Protheroe, C. A., Li, W., Colbert, D. C., Zellner, K. R., Shen, H. H., Luster, A. D., Irvin, C. G., Lee, J. J. & Lee, N. A., Dec 1 2013, In : American journal of respiratory cell and molecular biology. 49, 6, p. 1074-1084 11 p.

Research output: Contribution to journalArticle

17 Scopus citations

Eosinophilopoiesis

Maltby, S., McNagny, K. M., Ackerman, S. J., Du, J., Mori, Y., Iwasaki, H., Akashi, K., Takatsu, K., Rådinger, M., Bossios, A., Lötvall, J. & Lee, N. A., Aug 29 2013, Eosinophils in Health and Disease. Elsevier Inc., p. 73-119 47 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia

Nair, P., Ochkur, S. I., Protheroe, C., Radford, K., Efthimiadis, A., Lee, N. A. & Lee, J. J., Sep 1 2013, In : Allergy: European Journal of Allergy and Clinical Immunology. 68, 9, p. 1177-1184 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Expression of the secondary granule proteins major basic protein 1 (MBP-1) and eosinophil peroxidase (EPX) is required for eosinophilopoiesis in mice

Doyle, A. D., Jacobsen, E. A., Ochkur, S. I., McGarry, M. P., Shim, K. G., Nguyen, D. T. C., Protheroe, C., Colbert, D., Kloeber, J., Neely, J., Shim, K. P., Dyer, K. D., Rosenberg, H. F., Lee, J. J. & Lee, N. A., Aug 1 2013, In : Blood. 122, 5, p. 781-790 10 p.

Research output: Contribution to journalArticle

47 Scopus citations

Homologous recombination into the eosinophil peroxidase locus generates a strain of mice expressing Cre recombinase exclusively in eosinophils

Doyle, A. D., Jacobsen, E. A., Ochkur, S. I., Willetts, L., Shim, K., Neely, J., Kloeber, J., LeSuer, W. E., Pero, R. S., Lacy, P., Moqbel, R., Lee, N. A. & Lee, J. J., Jul 1 2013, In : Journal of Leukocyte Biology. 94, 1, p. 17-24 8 p.

Research output: Contribution to journalArticle

47 Scopus citations
2012

A sensitive high throughput ELISA for human eosinophil peroxidase: A specific assay to quantify eosinophil degranulation from patient-derived sources

Ochkur, S. I., Kim, J. D., Protheroe, C. A., Colbert, D., Condjella, R. M., Bersoux, S., Helmers, R. A., Moqbel, R., Lacy, P., Kelly, E. A., Jarjour, N. N., Kern, R., Peters, A., Schleimer, R. P., Furuta, G. T., Nair, P., Lee, J. J. & Lee, N. A., Oct 31 2012, In : Journal of Immunological Methods. 384, 1-2, p. 10-20 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

Eosinophils preserve parasitic nematode larvae by regulating local immunity

Gebreselassie, N. G., Moorhead, A. R., Fabre, V., Gagliardo, L. F., Lee, N. A., Lee, J. J. & Appleton, J. A., Jan 1 2012, In : Journal of Immunology. 188, 1, p. 417-425 9 p.

Research output: Contribution to journalArticle

60 Scopus citations

Human versus mouse eosinophils: "That which we call an eosinophil, by any other name would stain as red"

Lee, J. J., Jacobsen, E. A., Ochkur, S. I., McGarry, M. P., Condjella, R. M., Doyle, A. D., Luo, H., Zellner, K. R., Protheroe, C. A., Willetts, L., Lesuer, W. E., Colbert, D. C., Helmers, R. A., Lacy, P., Moqbel, R. & Lee, N. A., Sep 2012, In : Journal of Allergy and Clinical Immunology. 130, 3, p. 572-584 13 p.

Research output: Contribution to journalReview article

99 Scopus citations

The construction of transgenic and gene knockout/knockin mouse models of human disease

Doyle, A., McGarry, M. P., Lee, N. A. & Lee, J. J., Apr 1 2012, In : Transgenic Research. 21, 2, p. 327-349 23 p.

Research output: Contribution to journalReview article

90 Scopus citations

The development of a sensitive and specific ELISA for mouse eosinophil peroxidase: Assessment of eosinophil degranulation ex vivo and in models of human disease

Ochkur, S. I., Kim, J. D., Protheroe, C. A., Colbert, D., Moqbel, R., Lacy, P., Lee, J. J. & Lee, N. A., Jan 31 2012, In : Journal of Immunological Methods. 375, 1-2, p. 138-147 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

The expanding role(s) of eosinophils in health and disease

Jacobsen, E. A., Helmers, R. A., Lee, J. J. & Lee, N. A., Nov 8 2012, In : Blood. 120, 19, p. 3882-3890 9 p.

Research output: Contribution to journalReview article

104 Scopus citations
2011

Eosinophils

Lee, N. A., Dahl, M. V., Jacobsen, E. A. & Ochkur, S. I., Jul 27 2011, Inflammation and Allergy Drug Design. Wiley-Blackwell, p. 107-121 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Eosinophils increase neuron branching in human and murine skin and in vitro

Foster, E. L., Simpson, E. L., Fredrikson, L. J., Lee, J. J., Lee, N. A., Fryer, A. D. & Jacoby, D. B., 2011, In : PloS one. 6, 7, e22029.

Research output: Contribution to journalArticle

48 Scopus citations

Eosinophils regulate dendritic cells and Th2 pulmonary immune responses following allergen provocation

Jacobsen, E. A., Zellner, K. R., Colbert, D., Lee, N. A. & Lee, J. J., Dec 1 2011, In : Journal of Immunology. 187, 11, p. 6059-6068 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

Immunodetection of occult eosinophils in lung tissue biopsies may help predict survival in acute lung injury

Willetts, L., Parker, K., Wesselius, L. J., Protheroe, C. A., Jaben, E., Graziano, P., Moqbel, R., Leslie, K. O., Lee, N. A. & Lee, J. J., Aug 26 2011, In : Respiratory Research. 12, 116.

Research output: Contribution to journalArticle

19 Scopus citations

The identification of eosinophilic gastroenteritis in prednisone-dependent eosinophilic bronchitis and asthma

Nair, P., Ochkur, S. I., Protheroe, C., Simms, E., Lee, N. A. & Lee, J. J., Mar 1 2011, In : Allergy, Asthma and Clinical Immunology. 7, 1, 4.

Research output: Contribution to journalArticle

8 Scopus citations
2010

Airway eosinophilia in remission and progression of asthma: Accumulation with a fast decline of FEV1

Broekema, M., Volbeda, F., Timens, W., Dijkstra, A., Lee, N. A., Lee, J. J., Lodewijk, M. E., Postma, D. S., Hylkema, M. N. & Ten Hacken, N. H. T., Sep 1 2010, In : Respiratory Medicine. 104, 9, p. 1254-1262 9 p.

Research output: Contribution to journalArticle

46 Scopus citations

Eosinophils in health and disease: The LIAR hypothesis

Lee, J. J., Jacobsen, E. A., McGarry, M. P., Schleimer, R. P. & Lee, N. A., Apr 1 2010, In : Clinical and Experimental Allergy. 40, 4, p. 563-575 13 p.

Research output: Contribution to journalComment/debate

162 Scopus citations
2009

A Novel Histologic Scoring System to Evaluate Mucosal Biopsies From Patients With Eosinophilic Esophagitis

Protheroe, C., Woodruff, S. A., de Petris, G., Mukkada, V., Ochkur, S. I., Janarthanan, S., Lewis, J. C., Pasha, S., Lunsford, T., Harris, L., Sharma, V. K., McGarry, M. P., Lee, N. A., Furuta, G. T. & Lee, J. J., Jul 2009, In : Clinical Gastroenterology and Hepatology. 7, 7, p. 749-755.e11

Research output: Contribution to journalArticle

138 Scopus citations

Eosinophil deficiency compromises parasite survival in chronic nematode infection

Fabre, V., Beiting, D. P., Bliss, S. K., Gebreselassie, N. G., Gagliardo, L. F., Lee, N. A., Lee, J. J. & Appleton, J. A., Feb 1 2009, In : Journal of Immunology. 182, 3, p. 1577-1583 7 p.

Research output: Contribution to journalArticle

Open Access
107 Scopus citations
2008

Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells

Jacobsen, E. A., Ochkur, S. I., Pero, R. S., Taranova, A. G., Protheroe, C. A., Colbert, D. C., Lee, N. A. & Lee, J. J., Mar 17 2008, In : Journal of Experimental Medicine. 205, 3, p. 699-710 12 p.

Research output: Contribution to journalArticle

178 Scopus citations

Allergic pulmonary inflammation promotes the recruitment of circulating tumor cells to the lung

Taranova, A. G., Maldonado, D., Vachon, C. M., Jacobsen, E. A., Abdala-Valencia, H., McGarry, M. P., Ochkur, S. I., Protheroe, C. A., Doyle, A., Grant, C. S., Cook-Mills, J., Birnbaumer, L., Lee, N. A. & Lee, J. J., Oct 15 2008, In : Cancer research. 68, 20, p. 8582-8589 8 p.

Research output: Contribution to journalArticle

38 Scopus citations

Intestinal macrophage/epithelial cell-derived CCL11/eotaxin-1 mediates eosinophil recruitment and function in pediatric ulcerative colitis

Ahrens, R., Waddell, A., Seidu, L., Blanchard, C., Carey, R., Forbes, E., Lampinen, M., Wilson, T., Cohen, E., Stringer, K., Ballard, E., Munitz, A., Xu, H., Lee, N., Lee, J. J., Rothenberg, M. E., Denson, L. & Hogan, S. P., Nov 15 2008, In : Journal of Immunology. 181, 10, p. 7390-7399 10 p.

Research output: Contribution to journalArticle

Open Access
105 Scopus citations
2007

Coexpression of IL-5 and eotaxin-2 in mice creates an eosinophil-dependent model of respiratory inflammation with characteristics of severe asthma

Ochkur, S. I., Jacobsen, E. A., Protheroe, C. A., Biechele, T. L., Pero, R. S., McGarry, M. P., Wang, H., O'Neill, K. R., Colbert, D. C., Colby, T. V., Shen, H., Blackburn, M. R., Irvin, C. C., Lee, J. J. & Lee, N. A., Jun 15 2007, In : Journal of Immunology. 178, 12, p. 7879-7889 11 p.

Research output: Contribution to journalArticle

Open Access
117 Scopus citations

Eosinophils: Singularly destructive effector cells or purveyors of immunoregulation?

Jacobsen, E. A., Taranova, A. G., Lee, N. A. & Lee, J. J., Jun 1 2007, In : Journal of Allergy and Clinical Immunology. 119, 6, p. 1313-1320 8 p.

Research output: Contribution to journalArticle

153 Scopus citations

Eosinophils and asthma

Jacobsen, E. A., Ochkur, S. I., Lee, N. A. & Lee, J. J., Apr 1 2007, In : Current Allergy and Asthma Reports. 7, 1, p. 18-26 9 p.

Research output: Contribution to journalReview article

55 Scopus citations

i2-mediated signaling events in the endothelium are involved in controlling leukocyte extravasation

Pero, R. S., Borchers, M. T., Spicher, K., Ochkur, S. I., Sikora, L., Rao, S. P., Abdala-Valencia, H., O'Neill, K. R., Shen, H., McGarry, M. P., Lee, N. A., Cook-Mills, J. M., Sriramarao, P., Simon, M. I., Birnbaumer, L. & Lee, J. J., Mar 13 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 11, p. 4371-4376 6 p.

Research output: Contribution to journalArticle

47 Scopus citations
2006

CD69 expression on airway eosinophils and airway inflammation in a murine model of asthma

Wang, H. Y., Shen, H. H., Lee, J. J. & Lee, N. A., Dec 5 2006, In : Chinese medical journal. 119, 23, p. 1983-1990 8 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Lack of eosinophil peroxidase or major basic protein impairs defense against murine filarial infection

Specht, S., Saeftel, M., Arndt, M., Endl, E., Dubben, B., Lee, N. A., Lee, J. J. & Hoerauf, A., Sep 2006, In : Infection and Immunity. 74, 9, p. 5236-5243 8 p.

Research output: Contribution to journalArticle

66 Scopus citations

Pivotal Advance: Eosinophil infiltration of solid tumors is an early and persistent inflammatory host response

Cormier, S. A., Taranova, A. G., Bedient, C., Nguyen, T., Protheroe, C., Pero, R., Dimina, D., Ochkur, S. I., O'Neill, K., Colbert, D., Lombari, T. R., Constant, S., McGarry, M. P., Lee, J. J. & Lee, N. A., Jun 1 2006, In : Journal of Leukocyte Biology. 79, 6, p. 1131-1139 9 p.

Research output: Contribution to journalArticle

123 Scopus citations