• 958 Citations
  • 19 Scopus h-Index
20052020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

Survey Says: “COVID-19 Lockdown Hits Young Faculty and Clinical Trials”

Kent, D. G., Knapp, D. J. H. F. & Kannan, N., Jul 14 2020, In : Stem Cell Reports. 15, 1, p. 1-5 5 p.

Research output: Contribution to journalArticle

Open Access
2017

BRCA1 controls the cell division axis and governs ploidy and phenotype in human mammary cells

He, Z., Kannan, N., Nemirovsky, O., Chen, H., Connell, M., Taylor, B., Jiang, J., Pilarski, L. M., Fleisch, M. C., Niederacher, D., Pujana, M. A., Eaves, C. J. & Maxwell, C. A., 2017, In : Oncotarget. 8, 20, p. 32461-32475 15 p.

Research output: Contribution to journalArticle

6 Scopus citations

Mass Cytometric Analysis Reveals Viable Activated Caspase-3+ Luminal Progenitors in the Normal Adult Human Mammary Gland

Knapp, D. J. H. F., Kannan, N., Pellacani, D. & Eaves, C. J., Oct 24 2017, In : Cell Reports. 21, 4, p. 1116-1126 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1

Morris, E. J., Kawamura, E., Gillespie, J. A., Balgi, A., Kannan, N., Muller, W. J., Roberge, M. & Dedhar, S., May 5 2017, In : Nature Communications. 8, 15289.

Research output: Contribution to journalArticle

17 Scopus citations
2016

Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks

Pellacani, D., Bilenky, M., Kannan, N., Heravi-Moussavi, A., Knapp, D. J. H. F., Gakkhar, S., Moksa, M., Carles, A., Moore, R., Mungall, A. J., Marra, M. A., Jones, S. J. M., Aparicio, S., Hirst, M. & Eaves, C. J., Nov 15 2016, In : Cell Reports. 17, 8, p. 2060-2074 15 p.

Research output: Contribution to journalArticle

39 Scopus citations
2015

Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells

Nguyen, L. V., Pellacani, D., Lefort, S., Kannan, N., Osako, T., Makarem, M., Cox, C. L., Kennedy, W., Beer, P., Carles, A., Moksa, M., Bilenky, M., Balani, S., Babovic, S., Sun, I., Rosin, M., Aparicio, S., Hirst, M. & Eaves, C. J., Dec 10 2015, In : Nature. 528, 7581, p. 267-271 5 p.

Research output: Contribution to journalArticle

55 Scopus citations

Characterization of Epithelial Progenitors in Normal Human Palatine Tonsils and Their HPV16 E6/E7-Induced Perturbation

Kang, S. Y. C., Kannan, N., Zhang, L., Martinez, V., Rosin, M. P. & Eaves, C. J., Dec 8 2015, In : Stem Cell Reports. 5, 6, p. 1210-1225 16 p.

Research output: Contribution to journalArticle

11 Scopus citations

Disruption of IKAROS activity in primitive chronic-phase CML cells mimics myeloid disease progression

Beer, P. A., Knapp, D. J. H. F., Miller, P. H., Kannan, N., Sloma, I., Heel, K., Babovic, S., Bulaeva, E., Rabu, G., Terry, J., Druker, B. J., Loriaux, M. M., Loeb, K. R., Radich, J. P., Erber, W. N. & Eaves, C. J., Jan 15 2015, In : Blood. 125, 3, p. 504-515 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Dominant-negative IKAROS enhances IL-3-stimulated signaling in wild-type but not BCR-ABL1+ mouse BA/F3 cells

von Palffy, S., Bulaeva, E., Babovic, S., Kannan, N., Knapp, D. J. H. F., Wei, L., Eaves, C. J. & Beer, P. A., Jan 1 2015, In : Experimental Hematology. 43, 7, p. 514-523 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Hematopoietic PBX-interacting protein (HPIP) is over expressed in breast infiltrative ductal carcinoma and regulates cell adhesion and migration through modulation of focal adhesion dynamics

Bugide, S., David, D., Nair, A., Kannan, N., Samanthapudi, V. S. K., Prabhakar, J. & Manavathi, B., Aug 27 2015, In : Oncogene. 34, 35, p. 4601-4612 12 p.

Research output: Contribution to journalArticle

18 Scopus citations

RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1

Joshi, P. A., Waterhouse, P. D., Kannan, N., Narala, S., Fang, H., Di Grappa, M. A., Jackson, H. W., Penninger, J. M., Eaves, C. & Khokha, R., Jul 14 2015, In : Stem Cell Reports. 5, 1, p. 31-44 14 p.

Research output: Contribution to journalArticle

36 Scopus citations
2014

A dominant-negative isoform of IKAROS expands primitive normal human hematopoietic cells

Beer, P. A., Knapp, D. J. H. F., Kannan, N., Miller, P. H., Babovic, S., Bulaeva, E., Aghaeepour, N., Rabu, G., Rostamirad, S., Shih, K., Wei, L. & Eaves, C. J., Jan 1 2014, In : Stem Cell Reports. 3, 5, p. 841-857 17 p.

Research output: Contribution to journalArticle

16 Scopus citations

Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells

Nguyen, L. V., Makarem, M., Carles, A., Moksa, M., Kannan, N., Pandoh, P., Eirew, P., Osako, T., Kardel, M., Cheung, A. M. S., Kennedy, W., Tse, K., Zeng, T., Zhao, Y., Humphries, R. K., Aparicio, S., Eaves, C. J. & Hirst, M., Feb 6 2014, In : Cell Stem Cell. 14, 2, p. 253-263 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts

Nguyen, L. V., Cox, C. L., Eirew, P., Knapp, D. J. H. F., Pellacani, D., Kannan, N., Carles, A., Moksa, M., Balani, S., Shah, S., Hirst, M., Aparicio, S. & Eaves, C. J., 2014, In : Nature communications. 5, 1 p., 5871.

Research output: Contribution to journalArticle

43 Scopus citations

Glutathione-dependent and -independent oxidative stress-control mechanisms distinguish normal human mammary epithelial cell subsets

Kannan, N., Nguyen, L. V., Makarem, M., Dong, Y., Shih, K., Eirew, P., Raouf, A., Emerman, J. T. & Eaves, C. J., May 27 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 21, p. 7789-7794 6 p.

Research output: Contribution to journalArticle

42 Scopus citations

Δnp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling

Chakrabarti, R., Wei, Y., Hwang, J., Hang, X., Andres Blanco, M., Choudhury, A., Tiede, B., Romano, R. A., Decoste, C., Mercatali, L., Ibrahim, T., Amadori, D., Kannan, N., Eaves, C. J., Sinha, S. & Kang, Y., Oct 1 2014, In : Nature Cell Biology. 16, 10, p. 1004-1015 12 p.

Research output: Contribution to journalArticle

99 Scopus citations
2013

Developmental Changes in the in Vitro Activated Regenerative Activity of Primitive Mammary Epithelial Cells

Makarem, M., Kannan, N., Nguyen, L. V., Knapp, D. J. H. F., Balani, S., Prater, M. D., Stingl, J., Raouf, A., Nemirovsky, O., Eirew, P. & Eaves, C. J., Aug 2013, In : PLoS biology. 11, 8, e1001630.

Research output: Contribution to journalArticle

37 Scopus citations

Identification of novel small molecule inhibitors of centrosome clustering in cancer cells

Kawamura, E., Fielding, A. B., Kannan, N., Balgi, A., Eaves, C. J., Roberge, M. & Dedhar, S., Oct 2013, In : Oncotarget. 4, 10, p. 1763-1776 14 p.

Research output: Contribution to journalArticle

24 Scopus citations

The luminal progenitor compartment of the normal human mammary gland constitutes a unique site of telomere dysfunction

Kannan, N., Huda, N., Tu, L., Droumeva, R., Aubert, G., Chavez, E., Brinkman, R. R., Lansdorp, P., Emerman, J., Abe, S., Eaves, C. & Gilley, D., 2013, In : Stem Cell Reports. 1, 1, p. 28-37 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2012

Brief report: Aldehyde dehydrogenase activity is a biomarker of primitive normal human mammary luminal cells

Eirew, P., Kannan, N., Knapp, D. J. H. F., Vaillant, F., Emerman, J. T., Lindeman, G. J., Visvader, J. E. & Eaves, C. J., Feb 1 2012, In : Stem Cells. 30, 2, p. 344-348 5 p.

Research output: Contribution to journalArticle

57 Scopus citations
2010

MCF-7 breast cancer cells selected for tamoxifen resistance acquire new phenotypes differing in DNA content, phospho-HER2 and PAX2 expression, and rapamycin sensitivity

Leung, E., Kannan, N., Krissansen, G. W., Findlay, M. P. & Baguley, B. C., May 1 2010, In : Cancer Biology and Therapy. 9, 9, p. 717-724 8 p.

Research output: Contribution to journalArticle

Open Access
37 Scopus citations

Trefoil factor 3 is oncogenic and mediates anti-estrogen resistance in human mammary carcinoma

Kannan, N., Kang, I., Kong, X., Tang, J., Perry, J. K., Mohankumar, K. M., Miller, L. D., Liu, E. T., Mertani, H. C., Zhu, T., Grandison, P. M., Liu, D. X. & Lobie, P. E., Dec 2010, In : Neoplasia. 12, 12, p. 1041-1053 13 p.

Research output: Contribution to journalArticle

42 Scopus citations
2009

Trefoil factor-1 (TFF1) enhances oncogenicity of mammary carcinoma cells

Amiry, N., Kong, X., Muniraj, N., Kannan, N., Grandison, P. M., Lin, J., Yang, Y., Vouyovitch, C. M., Borges, S., Perry, J. K., Mertani, H. C., Zhu, T., Liu, D. & Lobie, P. E., Oct 2009, In : Endocrinology. 150, 10, p. 4473-4483 11 p.

Research output: Contribution to journalArticle

43 Scopus citations
2008

Transcriptional activation of signal transducer and activator of transcription (STAT) 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell

Mohankumar, K. M., Perry, J. K., Kannan, N., Kohno, K., Gluckman, P. D., Emerald, B. S. & Lobie, P. E., May 2008, In : Endocrinology. 149, 5, p. 2219-2229 11 p.

Research output: Contribution to journalArticle

22 Scopus citations
2007

HOXA1-stimulated oncogenicity is mediated by selective upregulation of components of the p44/42 MAP kinase pathway in human mammary carcinoma cells

Mohankumar, K. M., Xu, X. Q., Zhu, T., Kannan, N., Miller, L. D., Liu, E. T., Gluckman, P. D., Sukumar, S., Emerald, B. S. & Lobie, P. E., Jun 7 2007, In : Oncogene. 26, 27, p. 3998-4008 11 p.

Research output: Contribution to journalArticle

47 Scopus citations
2005

Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinoma

Xu, X. Q., Emerald, B. S., Goh, E. L. K., Kannan, N., Miller, L. D., Gluckman, P. D., Liut, E. T. & Lobie, P. E., Jun 24 2005, In : Journal of Biological Chemistry. 280, 25, p. 23987-24003 17 p.

Research output: Contribution to journalArticle

40 Scopus citations