Nadine Norton, PhD

  • 15231 Citations
  • 54 Scopus h-Index
19972020

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Article
2020

Folate receptor alpha expression associates with improved disease-free survival in triple negative breast cancer patients

Norton, N., Youssef, B., Hillman, D. W., Nassar, A., Geiger, X. J., Necela, B. M., Liu, H., Ruddy, K. J., Polley, M. Y. C., Ingle, J. N., Couch, F. J., Perez, E. A., Liu, M. C., Carter, J. M., Leon-Ferre, R. A., Boughey, J. C., Somers, E. B., Kalari, K. R., Visscher, D. W., Goetz, M. P. & 1 others, Knutson, K. L., Dec 1 2020, In : npj Breast Cancer. 6, 1, 4.

Research output: Contribution to journalArticle

Open Access

Rapid Generation of Sustainable HER2-specific T-cell Immunity in Patients with HER2 Breast Cancer using a Degenerate HLA Class II Epitope Vaccine

Knutson, K. L., Block, M. S., Norton, N., Erskine, C. L., Hobday, T. J., Dietz, A. B., Padley, D., Gustafson, M. P., Puglisi-Knutson, D., Mangskau, T. K., Chumsri, S., Dueck, A. C., Karyampudi, L., Wilson, G. & Degnim, A. C., Mar 1 2020, In : Clinical Cancer Research. 26, 5, p. 1045-1053 9 p.

Research output: Contribution to journalArticle

Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity

Ma, X., Zhu, P., Ding, Y., Zhang, H., Qiu, Q., Dvornikov, A. V., Wang, Z., Kim, M., Wang, Y., Lowerison, M., Yu, Y., Norton, N., Herrmann, J., Ekker, S. C., Hsiai, T. K., Lin, X. & Xu, X., Jan 29 2020, In : Science Advances. 6, 5, eaay2939.

Research output: Contribution to journalArticle

Open Access
2018

Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes

Knowles, D. A., Burrows, C. K., Blischak, J. D., Patterson, K. M., Serie, D. J., Norton, N., Ober, C., Pritchard, J. K. & Gilad, Y., May 8 2018, In : eLife. 7, e33480.

Research output: Contribution to journalArticle

15 Scopus citations

Generation of HER2-specific antibody immunity during trastuzumab adjuvant therapy associates with reduced relapse in resected HER2 breast cancer

Norton, N., Fox, N., McCarl, C. A., Tenner, K. S., Ballman, K., Erskine, C. L., Necela, B. M., Northfelt, D., Tan, W. W., Calfa, C., Pegram, M., Colon-Otero, G., Perez, E. A., Clynes, R. & Knutson, K. L., Jun 14 2018, In : Breast Cancer Research. 20, 1, 52.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Genome-wide association study of cardiotoxicity in the NCCTG N9831 (Alliance) adjuvant trastuzumab trial

Serie, D. J., Crook, J., Necela, B. M., Dockter, T. J., Wang, X., Asmann, Y., Fairweather, D., Bruno, K. A., Colon-Otero, G., Perez, E. A., Thompson, E. A. & Norton, N., 2017, In : Pharmacogenetics and Genomics. 27, 10, p. 378-385 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Intrinsic subtype and therapeutic response among HER2-positive breast tumors from the NCCTG (Alliance) N9831 trial

Perez, E. A., Ballman, K. V., Mashadi-Hossein, A., Tenner, K. S., Kachergus, J. M., Norton, N., Necela, B. M., Carr, J. M., Ferree, S., Perou, C. M., Baehner, F., Cheang, M. C. U. & Thompson, E. A., 2017, In : Journal of the National Cancer Institute. 109, 2

Research output: Contribution to journalArticle

17 Scopus citations

The antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes

Necela, B. M., Axenfeld, B. C., Serie, D. J., Kachergus, J. M., Perez, E. A., Thompson, E. A. & Norton, N., Jan 18 2017, In : Clinical and Translational Medicine. 6, 1, 5.

Research output: Contribution to journalArticle

2016

Assessment of tumor heterogeneity, as evidenced by gene expression profiles, pathway activation, and gene copy number, in patients with multifocal invasive lobular breast tumors

Norton, N., Advani, P. P., Serie, D. J., Geiger, X. J., Necela, B. M., Axenfeld, B. C., Kachergus, J. M., Feathers, R. W., Carr, J. M., Crook, J., Moreno Aspitia, A., Anastasiadis, P. Z., Perez, E. A. & Thompson, E. A., Apr 1 2016, In : PLoS One. 11, 4, e0153411.

Research output: Contribution to journalArticle

13 Scopus citations

Improved survival of HER2+ breast cancer patients treated with trastuzumab and chemotherapy is associated with host antibody immunity against the HER2 intracellular domain

Knutson, K. L., Clynes, R., Shreeder, B., Yeramian, P., Kemp, K. P., Ballman, K., Tenner, K. S., Erskine, C. L., Norton, N., Northfelt, D. W., Tan, W., Calfa, C., Pegram, M., Mittendorf, E. A. & Perez, E. A., Jul 1 2016, In : Cancer Research. 76, 13, p. 3702-3710 9 p.

Research output: Contribution to journalArticle

27 Scopus citations
2014

Association studies of Fcγ receptor polymorphisms with outcome in HER2+ breast cancer patients treated with trastuzumab in NCCTG (Alliance) Trial N9831

Norton, N., Olson, R. M., Pegram, M., Tenner, K., Ballman, K. V., Clynes, R., Knutson, K. L. & Perez, E. A., Oct 1 2014, In : Cancer immunology research. 2, 10, p. 962-969 8 p.

Research output: Contribution to journalArticle

24 Scopus citations
2013

Exome sequencing and genome-wide linkage analysis in 17 families illustrate the complex contribution of TTN truncating variants to dilated cardiomyopathy

Norton, N., Li, D., Rampersaud, E., Morales, A., Martin, E. R., Zuchner, S., Guo, S., Gonzalez, M., Hedges, D. J., Robertson, P. D., Krumm, N., Nickerson, D. A. & Hershberger, R. E., Apr 1 2013, In : Circulation: Cardiovascular Genetics. 6, 2, p. 144-153 10 p.

Research output: Contribution to journalArticle

68 Scopus citations

Gene expression, single nucleotide variant and fusion transcript discovery in archival material from breast tumors

Norton, N., Sun, Z., Asmann, Y. W., Serie, D. J., Necela, B. M., Bhagwate, A., Jen, J., Eckloff, B. W., Kalari, K. R., Thompson, K. J., Carr, J. M., Kachergus, J. M., Geiger, X. J., Perez, E. A. & Thompson, E. A., Nov 22 2013, In : PloS one. 8, 11, e81925.

Research output: Contribution to journalArticle

35 Scopus citations

Genetic schizophrenia risk variants jointly modulate total brain and white matter volume

Psychiatric Genome-wide association study (GWAS) Consortium, Mar 15 2013, In : Biological psychiatry. 73, 6, p. 525-531 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Genome-wide association analysis identifies 13 new risk loci for schizophrenia

Ripke, S., O'Dushlaine, C., Chambert, K., Moran, J. L., Kähler, A. K., Akterin, S., Bergen, S. E., Collins, A. L., Crowley, J. J., Fromer, M., Kim, Y., Lee, S. H., Magnusson, P. K. E., Sanchez, N., Stahl, E. A., Williams, S., Wray, N. R., Xia, K., Bettella, F., Borglum, A. D. & 147 others, Bulik-Sullivan, B. K., Cormican, P., Craddock, N., De Leeuw, C., Durmishi, N., Gill, M., Golimbet, V., Hamshere, M. L., Holmans, P., Hougaard, D. M., Kendler, K. S., Lin, K., Morris, D. W., Mors, O., Mortensen, P. B., Neale, B. M., O'Neill, F. A., Owen, M. J., Milovancevic, M. P., Posthuma, D., Powell, J., Richards, A. L., Riley, B. P., Ruderfer, D., Sigurdsson, E., Silagadze, T., Smit, A. B., Stefansson, H., Steinberg, S., Suvisaari, J., Tosato, S., Verhage, M., Walters, J. T., Levinson, D. F., Gejman, P. V., Laurent, C., Mowry, B. J., O'Donovan, M. C., Pulver, A. E., Schwab, S. G., Wildenauer, D. B., Dudbridge, F., Shi, J., Albus, M., Alexander, M., Campion, D., Cohen, D., Dikeos, D., Duan, J., Eichhammer, P., Godard, S., Hansen, M., Lerer, F. B., Liang, K. Y., Maier, W., Mallet, J., Nertney, D. A., Nestadt, G., Norton, N., Papadimitriou, G. N., Ribble, R., Sanders, A. R., Silverman, J. M., Walsh, D., Williams, N. M., Wormley, B., Arranz, M. J., Bakker, S., Bender, S., Bramon, E., Collier, D., Crespo-Facorro, B., Hall, J., Iyegbe, C., Jablensky, A., Kahn, R. S., Kalaydjieva, L., Lawrie, S., Lewis, C. M., Linszen, D. H., Mata, I., McIntosh, A., Murray, R. M., Ophoff, R. A., Rujescu, D., Van Os, J., Walshe, M., Weisbrod, M., Wiersma, D., Donnelly, P., Blackwell, J. M., Brown, M. A., Casas, J. P., Corvin, A. P., Duncanson, A., Jankowski, J., Markus, H. S., Mathew, C. G., Palmer, C. N. A., Plomin, R., Rautanen, A., Sawcer, S. J., Trembath, R. C., Viswanathan, A. C., Wood, N. W., Spencer, C. C. A., Band, G., Bellenguez, C., Freeman, C., Hellenthal, G., Giannoulatou, E., Pirinen, M., Pearson, R. D., Strange, A., Su, Z., Vukcevic, D., Langford, C., Hunt, S. E., Edkins, S., Gwilliam, R., Blackburn, H., Bumpstead, S. J., Dronov, S., Gillman, M., Gray, E., Hammond, N., Jayakumar, A., McCann, O. T., Liddle, J., Potter, S. C., Ravindrarajah, R., Ricketts, M., Tashakkori-Ghanbaria, A., Waller, M. J., Weston, P., Widaa, S., Whittaker, P., Barroso, I., Deloukas, P., McCarthy, M. I., Stefansson, K., Scolnick, E., Purcell, S., McCarroll, S. A., Sklar, P., Hultman, C. M. & Sullivan, P. F., Oct 1 2013, In : Nature Genetics. 45, 10, p. 1150-1159 10 p.

Research output: Contribution to journalArticle

901 Scopus citations

Return of genetic results in the familial dilated cardiomyopathy research project

Siegfried, J. D., Morales, A., Kushner, J. D., Burkett, E., Cowan, J., Mauro, A. C., Huggins, G. S., Li, D., Norton, N. & Hershberger, R. E., Apr 1 2013, In : Journal of Genetic Counseling. 22, 2, p. 164-174 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Schizophrenia genetic variants are not associated with intelligence

Van Scheltinga, A. F. T., Bakker, S. C., Van Haren, N. E. M., Derks, E. M., Buizer-Voskamp, J. E., Cahn, W., Ripke, S., Ophoff, R. A., Kahn, R. S., Ripke, S., Sanders, A. R., Kendler, K. S., Levinson, D. F., Sklar, P., Holmans, P. A., Lin, D. Y., Duan, J., Ophoff, R. A., Andreassen, O. A., Scolnick, E. & 185 others, Cichon, S., St Clair, D., Corvin, A., Gurling, H., Werge, T., Rujescu, D., Blackwood, D. H. R., Pato, C. N., Malhotra, A. K., Purcell, S., Dudbridge, F., Neale, B. M., Rossin, L., Visscher, P. M., Posthuma, D., Ruderfer, D. M., Fanous, A., Stefansson, H., Steinberg, S., Mowry, B. J., Golimbet, V., De Hert, M., Jönsson, E. G., Bitter, I., Pietiläinen, O. P. H., Collier, D. A., Tosato, S., Agartz, I., Albus, M., Alexander, M., Amdur, R. L., Amin, F., Bass, N., Bergen, S. E., Black, D. W., Børglum, A. D., Brown, M. A., Bruggeman, R., Buccola, N. G., Byerley, W. F., Cahn, W., Cantor, R. M., Carr, V. J., Catts, S. V., Choudhury, K., Cloninger, C. R., Cormican, P., Craddock, N., Danoy, P. A., Datta, S., De Haan, L., Demontis, D., Dikeos, D., Djurovic, S., Donnelly, P., Donohoe, G., Duong, L., Dwyer, S., Fink-Jensen, A., Freedman, R., Freimer, N. B., Friedl, M., Georgieva, L., Giegling, I., Gill, M., Glenthøj, B., Godard, S., Hamshere, M., Hansen, M., Hansen, T., Hartmann, A. M., Henskens, F. A., Hougaard, D. M., Hultman, C. M., Ingason, A., Jablensky, A. V., Jakobsen, K. D., Jay, M., Jürgens, G., Kahn, R. S., Keller, M. C., Kenis, G., Kenny, E., Kim, Y., Kirov, G. K., Konnerth, H., Konte, B., Krabbendam, L., Krasucki, R., Lasseter, V. K., Laurent, C., Lawrence, J., Lencz, T., Lerer, F. B., Liang, K. Y., Lichtenstein, P., Lieberman, J. A., Linszen, D. H., Lönnqvist, J., Loughland, C. M., Maclean, A. W., Maher, B. S., Maier, W., Mallet, J., Malloy, P., Mattheisen, M., Mattingsdal, M., McGhee, K. A., McGrath, J. J., McIntosh, A., McLean, D. E., McQuillin, A., Melle, I., Michie, P. T., Milanova, V., Morris, D. W., Mors, O., Mortensen, P. B., Moskvina, V., Muglia, P., Myin-Germeys, I., Nertney, D. A., Nestadt, G., Nielsen, J., Nikolov, I., Nordentoft, M., Norton, N., Nöthen, M. M., O'Dushlaine, C. T., Olincy, A., Olsen, L., O'Neill, F. A., Ørntoft, T. F., Owen, M. J., Pantelis, C., Papadimitriou, G., Pato, M. T., Peltonen, L., Petursson, H., Pickard, B., Pimm, J., Pulver, A. E., Puri, V., Quested, D., Quinn, E. M., Rasmussen, H. B., Réthelyi, J. M., Ribble, R., Rietschel, M., Riley, B. P., Ruggeri, M., Schall, U., Schulze, T. G., Schwab, S. G., Scott, R. J., Shi, J., Sigurdsson, E., Silverman, J. M., Spencer, C. C. A., Stefansson, K., Strange, A., Strengman, E., Stroup, T. S., Suvisaari, J., Terenius, L., Thirumalai, S., Thygesen, J. H., Timm, S., Toncheva, D., Van Den Oord, E., Van Os, J., Van Winkel, R., Veldink, J., Walsh, D., Wang, A. G., Wiersma, D., Wildenauer, D. B., Williams, H. J., Williams, N. M., Wormley, B., Zammit, S., Sullivan, P. F., O'Donovan, M. C., Daly, M. J. & Gejman, P. V., Dec 1 2013, In : Psychological Medicine. 43, 12, p. 2563-2570 8 p.

Research output: Contribution to journalArticle

27 Scopus citations
2012

A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia

The International schizophrenia consortium, Feb 1 2012, In : Journal of medical genetics. 49, 2, p. 96-103 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

Evaluating pathogenicity of rare variants from dilated cardiomyopathy in the exome era

Norton, N., Robertson, P. D., Rieder, M. J., Züchner, S., Rampersaud, E., Martin, E., Li, D., Nickerson, D. A. & Hershberger, R. E., Apr 1 2012, In : Circulation: Cardiovascular Genetics. 5, 2, p. 167-174 8 p.

Research output: Contribution to journalArticle

87 Scopus citations

Genome-wide association study of multiplex schizophrenia pedigrees

Levinson, D. F., Shi, J., Wang, K., Oh, S., Riley, B., Pulver, A. E., Wildenauer, D. B., Laurent, C., Mowry, B. J., Gejman, P. V., Owen, M. J., Kendler, K. S., Nestadt, G., Schwab, S. G., Mallet, J., Nertney, D., Sanders, A. R., Williams, N. M., Wormley, B., Lasseter, V. K. & 26 others, Albus, M., Godard-Bauché, S., Alexander, M., Duan, J., O'Donovan, M. C., Walsh, D., O'Neill, A., Papadimitriou, G. N., Dikeos, D., Maier, W., Lerer, B., Campion, D., Cohen, D., Jay, M., Fanous, A., Eichhammer, P., Silverman, J. M., Norton, N., Zhang, N., Hakonarson, H., Gao, C., Citri, A., Hansen, M., Ripke, S., Dudbridge, F. & Holmans, P. A., Aug 1 2012, In : American Journal of Psychiatry. 169, 9, p. 963-973 11 p.

Research output: Contribution to journalArticle

45 Scopus citations
2011

Assessment of LMNA copy number variation in 58 probands with dilated cardiomyopathy.

Norton, N., Siegfried, J. D., Li, D. & Hershberger, R. E., Oct 2011, In : Clinical and translational science. 4, 5, p. 351-352 2 p.

Research output: Contribution to journalArticle

9 Scopus citations

Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder

Williams, H. J., Norton, N., Dwyer, S., Moskvina, V., Nikolov, I., Carroll, L., Georgieva, L., Williams, N. M., Morris, D. W., Quinn, E. M., Giegling, I., Ikeda, M., Wood, J., Lencz, T., Hultman, C., Lichtenstein, P., Thiselton, D., Maher, B. S., Malhotra, A. K., Riley, B. & 13 others, Kendler, K. S., Gill, M., Sullivan, P., Sklar, P., Purcell, S., Nimgaonkar, V. L., Kirov, G., Holmans, P., Corvin, A., Rujescu, D., Craddock, N., Owen, M. J. & O'Donovan, M. C., Apr 1 2011, In : Molecular Psychiatry. 16, 4, p. 429-441 13 p.

Research output: Contribution to journalArticle

201 Scopus citations

Functional characterization of TNNC1 rare variants identified in dilated cardiomyopathy

Pinto, J. R., Siegfried, J. D., Parvatiyar, M. S., Li, D., Norton, N., Jones, M. A., Liang, J., Potter, J. D. & Hershberger, R. E., Oct 30 2011, In : Journal of Biological Chemistry. 286, 39, p. 34404-34412 9 p.

Research output: Contribution to journalArticle

31 Scopus citations

Genetic classification of populations using supervised learning

The International Schizophrenia Consortium (ISC), Jan 1 2011, In : PloS one. 6, 5, e14802.

Research output: Contribution to journalArticle

12 Scopus citations

Genome-wide association study identifies five new schizophrenia loci

Ripke, S., Sanders, A. R., Kendler, K. S., Levinson, D. F., Sklar, P., Holmans, P. A., Lin, D. Y., Duan, J., Ophoff, R. A., Andreassen, O. A., Scolnick, E., Cichon, S., St. Clair, D., Corvin, A., Gurling, H., Werge, T., Rujescu, D., Blackwood, D. H. R., Pato, C. N., Malhotra, A. K. & 176 others, Purcell, S., Dudbridge, F., Neale, B. M., Rossin, L., Visscher, P. M., Posthuma, D., Ruderfer, D. M., Fanous, A., Stefansson, H., Steinberg, S., Mowry, B. J., Golimbet, V., De Hert, M., Jönsson, E. G., Bitter, I., Pietiläinen, O. P. H., Collier, D. A., Tosato, S., Agartz, I., Albus, M., Alexander, M., Amdur, R. L., Amin, F., Bass, N., Bergen, S. E., Black, D. W., Børglum, A. D., Brown, M. A., Bruggeman, R., Buccola, N. G., Byerley, W. F., Cahn, W., Cantor, R. M., Carr, V. J., Catts, S. V., Choudhury, K., Cloninger, C. R., Cormican, P., Craddock, N., Danoy, P. A., Datta, S., De Haan, L., Demontis, D., Dikeos, D., Djurovic, S., Donnelly, P., Donohoe, G., Duong, L., Dwyer, S., Fink-Jensen, A., Freedman, R., Freimer, N. B., Friedl, M., Georgieva, L., Giegling, I., Gill, M., Glenthøj, B., Godard, S., Hamshere, M., Hansen, M., Hansen, T., Hartmann, A. M., Henskens, F. A., Hougaard, D. M., Hultman, C. M., Ingason, A., Jablensky, A. V., Jakobsen, K. D., Jay, M., Jürgens, G., Kahn, R. S., Keller, M. C., Kenis, G., Kenny, E., Kim, Y., Kirov, G. K., Konnerth, H., Konte, B., Krabbendam, L., Krasucki, R., Lasseter, V. K., Laurent, C., Lawrence, J., Lencz, T., Lerer, F. B., Liang, K. Y., Lichtenstein, P., Lieberman, J. A., Linszen, D. H., Lönnqvist, J., Loughland, C. M., MacLean, A. W., Maher, B. S., Maier, W., Mallet, J., Malloy, P., Mattheisen, M., Mattingsdal, M., McGhee, K. A., McGrath, J. J., McIntosh, A., McLean, D. E., McQuillin, A., Melle, I., Michie, P. T., Milanova, V., Morris, D. W., Mors, O., Mortensen, P. B., Moskvina, V., Muglia, P., Myin-Germeys, I., Nertney, D. A., Nestadt, G., Nielsen, J., Nikolov, I., Nordentoft, M., Norton, N., Nöthen, M. M., O'Dushlaine, C. T., Olincy, A., Olsen, L., O'Neill, F. A., Ørntoft, T. F., Owen, M. J., Pantelis, C., Papadimitriou, G., Pato, M. T., Peltonen, L., Petursson, H., Pickard, B., Pimm, J., Pulver, A. E., Puri, V., Quested, D., Quinn, E. M., Rasmussen, H. B., Réthelyi, J. M., Ribble, R., Rietschel, M., Riley, B. P., Ruggeri, M., Schall, U., Schulze, T. G., Schwab, S. G., Scott, R. J., Shi, J., Sigurdsson, E., Silverman, J. M., Spencer, C. C. A., Stefansson, K., Strange, A., Strengman, E., Stroup, T. S., Suvisaari, J., Terenius, L., Thirumalai, S., Thygesen, J. H., Timm, S., Toncheva, D., Van Den Oord, E., Van Os, J., Van Winkel, R., Veldink, J., Walsh, D., Wang, A. G., Wiersma, D., Wildenauer, D. B., Williams, H. J., Williams, N. M., Wormley, B., Zammit, S., Sullivan, P. F., O'Donovan, M. C., Daly, M. J. & Gejman, P. V., Oct 2011, In : Nature Genetics. 43, 10, p. 969-978 10 p.

Research output: Contribution to journalArticle

1256 Scopus citations

Genome-wide studies of copy number variation and exome sequencing identify rare variants in BAG3 as a cause of dilated cardiomyopathy

Norton, N., Li, D., Rieder, M. J., Siegfried, J. D., Rampersaud, E., Züchner, S., Mangos, S., Gonzalez-Quintana, J., Wang, L., McGee, S., Reiser, J., Martin, E., Nickerson, D. A. & Hershberger, R. E., Mar 11 2011, In : American journal of human genetics. 88, 3, p. 273-282 10 p.

Research output: Contribution to journalArticle

207 Scopus citations

GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia

Chen, X., Lee, G., Maher, B. S., Fanous, A. H., Chen, J., Zhao, Z., Guo, A., Van Den Oord, E., Sullivan, P. F., Shi, J., Levinson, D. F., Gejman, P. V., Sanders, A., Duan, J., Owen, M. J., Craddock, N. J., O'Donovan, M. C., Blackman, J., Lewis, D., Kirov, G. K. & 107 others, Qin, W., Schwab, S., Wildenauer, D., Chowdari, K., Nimgaonkar, V., Straub, R. E., Weinberger, D. R., O'Neill, F. A., Walsh, D., Bronstein, M., Darvasi, A., Lencz, T., Malhotra, A. K., Rujescu, D., Giegling, I., Werge, T., Hansen, T., Ingason, A., Nöethen, M. M., Rietschel, M., Cichon, S., Djurovic, S., Andreassen, O. A., Cantor, R. M., Ophoff, R., Corvin, A., Morris, D. W., Gill, M., Pato, C. N., Pato, M. T., Macedo, A., Gurling, H. M. D., McQuillin, A., Pimm, J., Hultman, C., Lichtenstein, P., Sklar, P., Purcell, S. M., Scolnick, E., St Clair, D., Blackwood, D. H. R., Kendler, K. S., Kahn, R. S., Linszen, D. H., Van Os, J., Wiersma, D., Bruggeman, R., Cahn, W., De Haan, L., Krabbendam, L., Myin-Germeys, I., Holmans, P. A., Williams, N. M., Georgieva, L., Nikolov, I., Norton, N., Williams, H., Toncheva, D., Milanova, V., Hultman, C. M., Thelander, E. F., Sullivan, P., O'Dushlaine, C. T., Kenny, E., Quinn, E. M., Choudhury, K., Datta, S., Thirumalai, S., Puri, V., Krasucki, R., Lawrence, J., Quested, D., Bass, N., Gurling, H., Crombie, C., Fraser, G., Kuan, S. L., Walker, N., Muir, W. J., McGhee, K. A., Pickard, B., Malloy, P., Maclean, A. W., Van Beck, M., Wray, N. R., Macgregor, S., Visscher, P. M., Medeiros, H., Middleton, F., Carvalho, C., Morley, C., Fanous, A., Conti, D., Knowles, J. A., Ferreira, C. P., Azevedo, M. H., Stone, J. L., Ruderfer, D. M., Kirby, A. N., Ferreira, M. A. R., Daly, M. J., Chambert, K., Kuruvilla, F., Gabriel, S. B., Ardlie, K., Moran, J. L. & Scolnick, E. M., Nov 1 2011, In : Molecular Psychiatry. 16, 11, p. 1117-1129 13 p.

Research output: Contribution to journalArticle

Open Access
53 Scopus citations

Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility

The International schizophrenia consortium, Mar 1 2011, In : Molecular Psychiatry. 16, 3, p. 286-292 7 p.

Research output: Contribution to journalArticle

157 Scopus citations

Phenotype evaluation and genomewide linkage study of clinical variables in schizophrenia

Hamshere, M. L., Holmans, P. A., McCarthy, G. M., Jones, L. A., Murphy, K. C., Sanders, R. D., Gray, M. Y., Zammit, S., Williams, N. M., Norton, N., Williams, H. J., McGuffin, P., O'Donovan, M. C., Craddock, N., Owen, M. J. & Cardno, A. G., Dec 1 2011, In : American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 156, 8, p. 929-940 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Rare variant mutations identified in pediatric patients with dilated cardiomyopathy

Rampersaud, E., Siegfried, J. D., Norton, N., Li, D., Martin, E. & Hershberger, R. E., Jan 1 2011, In : Progress in Pediatric cardiology. 31, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

41 Scopus citations

Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia

The International schizophrenia consortium, Sep 1 2011, In : Schizophrenia Research. 131, 1-3, p. 43-51 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
2010

Accurately assessing the risk of schizophrenia conferred by rare copy-number variation affecting genes with brain function

The International schizophrenia consortium, Sep 1 2010, In : PLoS genetics. 6, 9, e1001097.

Research output: Contribution to journalArticle

100 Scopus citations

Coding sequence rare variants identified in MYBPC3, MYH6, TPM1, TNNC1, and TNNI3 from 312 patients with familial or idiopathic dilated cardiomyopathy

Hershberger, R. E., Norton, N., Morales, A., Li, D., Siegfried, J. D. & Gonzalez-Quintana, J., Apr 1 2010, In : Circulation: Cardiovascular Genetics. 3, 2, p. 155-161 7 p.

Research output: Contribution to journalArticle

139 Scopus citations

Evidence for rare and common genetic risk variants for schizophrenia at protein kinase C, alpha

Carroll, L. S., Williams, N. M., Moskvina, V., Russell, E., Norton, N., Williams, H. J., Peirce, T., Georgieva, L., Dwyer, S., Grozeva, D., Greene, E., Farmer, A., McGuffin, P., Morris, D. W., Corvin, A., Gill, M., Rujescu, D., Sham, P., Holmans, P., Jones, I. & 4 others, Kirov, G., Craddock, N., O'Donovan, M. C. & Owen, M. J., Nov 1 2010, In : Molecular Psychiatry. 15, 11, p. 1101-1111 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Identification of novel mutations in RBM20 in patients with dilated cardiomyopathy

Li, D., Morales, A., Gonzalez-Quintana, J., Norton, N., Siegfried, J. D., Hofmeyer, M. & Hershberger, R. E., Jun 1 2010, In : Clinical and translational science. 3, 3, p. 90-97 8 p.

Research output: Contribution to journalArticle

95 Scopus citations

Late onset sporadic dilated cardiomyopathy caused by a cardiac troponin T mutation

Morales, A., Pinto, J. R., Siegfried, J. D., Li, D., Norton, N., Hofmeyer, M., Vallin, M., Morales, A. R., Potter, J. D. & Hershberger, R. E., Oct 1 2010, In : Clinical and translational science. 3, 5, p. 219-226 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia

Walters, J. T. R., Corvin, A., Owen, M. J., Williams, H., Dragovic, M., Quinn, E. M., Judge, R., Smith, D. J., Norton, N., Giegling, I., Hartmann, A. M., Möller, H. J., Muglia, P., Moskvina, V., Dwyer, S., O'Donoghue, T., Morar, B., Cooper, M., Chandler, D., Jablensky, A. & 6 others, Gill, M., Kaladjieva, L., Morris, D. W., O'Donovan, M. C., Rujescu, D. & Donohoe, G., Jul 1 2010, In : Archives of General Psychiatry. 67, 7, p. 692-700 9 p.

Research output: Contribution to journalArticle

105 Scopus citations

Rare variant mutations in pregnancy-associated or peripartum cardiomyopathy

Morales, A., Painter, T., Li, R., Siegfried, J. D., Li, D., Norton, N. & Hershberger, R. E., May 25 2010, In : Circulation. 121, 20, p. 2176-2182 7 p.

Research output: Contribution to journalArticle

121 Scopus citations

SCN5A Rare Variants in Familial Dilated Cardiomyopathy Decrease Peak Sodium Current Depending on the Common Polymorphism H558R and Common Splice Variant Q1077del

Cheng, J., Morales, A., Siegfried, J. D., Li, D., Norton, N., Song, J., Gonzalez-Quintana, J., Makielski, J. C. & Hershberger, R. E., Dec 1 2010, In : Clinical and translational science. 3, 6, p. 287-294 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Strong genetic evidence for a selective influence of GABA A receptors on a component of the bipolar disorder phenotype

Craddock, N., Jones, L., Jones, I. R., Kirov, G., Green, E. K., Grozeva, D., Moskvina, V., Nikolov, I., Hamshere, M. L., Vukcevic, D., Caesar, S., Gordon-Smith, K., Fraser, C., Russell, E., Norton, N., Breen, G., St Clair, D., Collier, D. A., Young, A. H., Ferrier, I. N. & 6 others, Farmer, A., McGuffin, P., Holmans, P. A., Donnelly, P., Owen, M. J. & O'Donovan, M. C., Jan 2010, In : Molecular Psychiatry. 15, 2, p. 146-153 8 p.

Research output: Contribution to journalArticle

95 Scopus citations
2009

Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2

O'Donovan, M. C., Norton, N., Williams, H., Peirce, T., Moskvina, V., Nikolov, I., Hamshere, M., Carroll, L., Georgieva, L., Dwyer, S., Holmans, P., Marchini, J. L., Spencer, C. C. A., Howie, B., Leung, H. T., Giegling, I., Hartmann, A. M., Möller, H. J., Morris, D. W., Shi, Y. & 44 others, Feng, G., Hoffmann, P., Propping, P., Vasilescu, C., Maier, W., Rietschel, M., Zammit, S., Schumacher, J., Quinn, E. M., Schulze, T. G., Iwata, N., Ikeda, M., Darvasi, A., Shifman, S., He, L., Duan, J., Sanders, A. R., Levinson, D. F., Adolfsson, R., Ösby, U., Terenius, L., Jönsson, E. G., Cichon, S., Nöthen, M. M., Gill, M., Corvin, A. P., Rujescu, D., Gejman, P. V., Kirov, G., Craddock, N., Williams, N. M., Owen, M. J., Gejman, P. V., Sanders, A. R., Duan, J., Levinson, D. F., Buccola, N. G., Mowry, B. J., Freedman, R., Amin, F., Black, D. W., Silverman, J. M., Byerley, W. J. & Cloninger, C. R., Jan 25 2009, In : Molecular Psychiatry. 14, 1, p. 30-36 7 p.

Research output: Contribution to journalArticle

52 Scopus citations

Common polygenic variation contributes to risk of schizophrenia and bipolar disorder

Purcell, S. M., Wray, N. R., Stone, J. L., Visscher, P. M., O'Donovan, M. C., Sullivan, P. F., Ruderfer, D. M., McQuillin, A., Morris, D. W., Oĝdushlaine, C. T., Corvin, A., Holmans, P. A., Oĝdonovan, M. C., MacGregor, S., Gurling, H., Blackwood, D. H. R., Craddock, N. J., Gill, M., Hultman, C. M., Kirov, G. K. & 55 others, Lichtenstein, P., Muir, W. J., Owen, M. J., Pato, C. N., Scolnick, E. M., St Clair, D., Williams, N. M., Georgieva, L., Nikolov, I., Norton, N., Williams, H., Toncheva, D., Milanova, V., Thelander, E. F., O'Dushlaine, C. T., Kenny, E., Quinn, E. M., Choudhury, K., Datta, S., Pimm, J., Thirumalai, S., Puri, V., Krasucki, R., Lawrence, J., Quested, D., Bass, N., Crombie, C., Fraser, G., Leh Kuan, S., Walker, N., McGhee, K. A., Pickard, B., Malloy, P., MacLean, A. W., Van Beck, M., Pato, M. T., Medeiros, H., Middleton, F., Carvalho, C., Morley, C., Fanous, A., Conti, D., Knowles, J. A., Paz Ferreira, C., MacEdo, A., Helena Azevedo, M., Kirby, A. N., Ferreira, M. A. R., Daly, M. J., Chambert, K., Kuruvilla, F., Gabriel, S. B., Ardlie, K., Moran, J. L. & Sklar, P., Aug 6 2009, In : Nature. 460, 7256, p. 748-752 5 p.

Research output: Contribution to journalArticle

2789 Scopus citations

Genomewide linkage scan of schizophrenia in a large multicenter pedigree sample using single nucleotide polymorphisms

Holmans, P. A., Riley, B., Pulver, A. E., Owen, M. J., Wildenauer, D. B., Gejman, P. V., Mowry, B. J., Laurent, C., Kendler, K. S., Nestadt, G., Williams, N. M., Schwab, S. G., Sanders, A. R., Nertney, D., Mallet, J., Wormley, B., Lasseter, V. K., O'Donovan, M. C., Duan, J., Albus, M. & 15 others, Alexander, M., Godard, S., Ribble, R., Liang, K. Y., Norton, N., Maier, W., Papadimitriou, G., Walsh, D., Jay, M., O'Neill, A., Lerer, F. B., Dikeos, D., Crowe, R. R., Silverman, J. M. & Levinson, D. F., Aug 2009, In : Molecular Psychiatry. 14, 8, p. 786-795 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

Identifying relationships among genomic disease regions: Predicting genes at pathogenic SNP associations and rare deletions

Raychaudhuri, S., Plenge, R. M., Rossin, E. J., Ng, A. C. Y., Purcell, S. M., Sklar, P., Scolnick, E. M., Xavier, R. J., Altshuler, D., Daly, M. J., Ardlie, K., Azevedo, M. H., Bass, N., Blackwood, D. H. R., Carvalho, C., Chambert, K., Choudhury, K., Conti, D., Corvin, A., Craddock, N. J. & 57 others, Crombie, C., Curtis, D., Datta, S., Gabrie, S. B., Gates, C., Georgieva, L., Gill, M., Gurling, H., Holmans, P. A., Hultman, C. M., Fanous, A., Fraser, G., Kenny, E., Kirov, G. K., Knowles, J. A., Krasucki, R., Korn, J., Soh, L. K., Lawrence, J., Lichtenstein, P., Macedo, A., Macgregor, S., Maclean, A. W., Mahon, S., Malloy, P., McGhee, K. A., McQuillin, A., Medeiros, H., Middleton, F., Milanova, V., Morley, C., Morris, D. W., Muir, W. J., Nikolov, I., Norton, N., O'Dushlaine, C. T., O'Donovan, M. C., Owen, M. J., Pato, C. N., Ferreira, C. P., Pickard, B., Pimm, J., Puri, V., Quested, D., Ruderfer, D. M., St. Clair, D., Stone, J. L., Sullivan, P. F., Thelander, E. F., Thirumalai, S., Toncheva, D., Van Beck, M., Visscher, P. M., Waddington, J. L., Walker, N., Williams, H. & Williams, N. M., Jun 1 2009, In : PLoS genetics. 5, 6, e1000534.

Research output: Contribution to journalArticle

323 Scopus citations

Influence of NOS1 on verbal intelligence and working memory in both patients with schizophrenia and healthy control subjects

Donohoe, G., Walters, J., Morris, D. W., Quinn, E. M., Judge, R., Norton, N., Giegling, I., Hartmann, A. M., Möller, H. J., Muglia, P., Williams, H., Moskvina, V., Peel, R., O'Donoghue, T., Owen, M. J., O'Donovan, M. C., Gill, M., Rujescu, D. & Corvin, A., Oct 1 2009, In : Archives of General Psychiatry. 66, 10, p. 1045-1054 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Meta-analysis of 32 genome-wide linkage studies of schizophrenia

Ng, M. Y. M., Levinson, D. F., Faraone, S. V., Suarez, B. K., Delisi, L. E., Arinami, T., Riley, B., Paunio, T., Pulver, A. E., Irmansyah, Holmans, P. A., Escamilla, M., Wildenauer, D. B., Williams, N. M., Laurent, C., Mowry, B. J., Brzustowicz, L. M., Maziade, M., Sklar, P., Garver, D. L. & 62 others, Abecasis, G. R., Lerer, B., Fallin, M. D., Gurling, H. M. D., Gejman, P. V., Lindholm, E., Moises, H. W., Byerley, W., Wijsman, E. M., Forabosco, P., Tsuang, M. T., Hwu, H. G., Okazaki, Y., Kendler, K. S., Wormley, B., Fanous, A., Walsh, D., O'Neill, F. A., Peltonen, L., Nestadt, G., Lasseter, V. K., Liang, K. Y., Papadimitriou, G. M., Dikeos, D. G., Schwab, S. G., Owen, M. J., O'Donovan, M. C., Norton, N., Hare, E., Raventos, H., Nicolini, H., Albus, M., Maier, W., Nimgaonkar, V. L., Terenius, L., Mallet, J., Jay, M., Godard, S., Nertney, D., Alexander, M., Crowe, R. R., Silverman, J. M., Bassett, A. S., Roy, M. A., Mérette, C., Pato, C. N., Pato, M. T., Roos, J. L., Kohn, Y., Amann-Zalcenstein, D., Kalsi, G., McQuillin, A., Curtis, D., Brynjolfson, J., Sigmundsson, T., Petursson, H., Sanders, A. R., Duan, J., Jazin, E., Myles-Worsley, M., Karayiorgou, M. & Lewis, C. M., Aug 1 2009, In : Molecular Psychiatry. 14, 8, p. 774-785 12 p.

Research output: Contribution to journalArticle

175 Scopus citations

Support for the involvement of large copy number variants in the pathogenesis of schizophrenia

Kirov, G., Grozeva, D., Norton, N., Ivanov, D., Mantripragada, K. K., Holmans, P., Craddock, N., Owen, M. J. & O'Donovan, M. C., Apr 20 2009, In : Human molecular genetics. 18, 8, p. 1497-1503 7 p.

Research output: Contribution to journalArticle

311 Scopus citations

Whole genome association study in a homogenous population in Shandong peninsula of China reveals JARID2 as a susceptibility gene for schizophrenia

Chen, G., Liu, Y., Norton, N., Liu, W., Zhu, H., Zhou, P., Luan, M., Yang, S., Chen, X., Carroll, L., Williams, N. M., O'Donovan, M. C., Kirov, G. & Owen, M. J., Dec 9 2009, In : Journal of Biomedicine and Biotechnology. 2009, 536918.

Research output: Contribution to journalArticle

27 Scopus citations
2008

Analysis of copy number variation using quantitative interspecies competitive PCR.

Williams, N. M., Williams, H., Majounie, E., Norton, N., Glaser, B., Morris, H. R., Owen, M. J. & O'Donovan, M. C., Oct 2008, In : Nucleic acids research. 36, 17, p. e112

Research output: Contribution to journalArticle

9 Scopus citations

Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia

Kirov, G., Gumus, D., Chen, W., Norton, N., Georgieva, L., Sari, M., O'Donovan, M. C., Erdogan, F., Owen, M. J., Ropers, H. H. & Ullmann, R., Feb 1 2008, In : Human molecular genetics. 17, 3, p. 458-465 8 p.

Research output: Contribution to journalArticle

304 Scopus citations