• 2223 Citations
  • 26 Scopus h-Index
1987 …2019
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Research Output 1991 2019

  • 2223 Citations
  • 26 Scopus h-Index
  • 92 Article
  • 1 Letter
  • 1 Short survey
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Article
2019

Amplification-free long-read sequencing of TCF4 expanded trinucleotide repeats in Fuchs Endothelial Corneal Dystrophy

Wieben, E. D., Aleff, R. A., Basu, S., Sarangi, V., Bowman, B., McLaughlin, I. J., Mills, J. R., Butz, M. L., Highsmith, W. E. J., Ida, C. M., Ekholm, J. M., Baratz, K. & Fautsch, M. P., Jan 1 2019, In : PloS one. 14, 7, e0219446.

Research output: Contribution to journalArticle

Open Access
Fuchs' Endothelial Dystrophy
Trinucleotide Repeat Expansion
Trinucleotide Repeats
Amplification
microsatellite repeats

Association of rs613872 and Trinucleotide Repeat Expansion in the TCF4 Gene of German Patients With Fuchs Endothelial Corneal Dystrophy

Okumura, N., Hayashi, R., Nakano, M., Tashiro, K., Yoshii, K., Aleff, R., Butz, M., Highsmith, W. E. J., Wieben, E. D., Fautsch, M. P., Baratz, K., Komori, Y., Ueda, E., Nakahara, M., Weller, J., Tourtas, T., Schlötzer-Schrehardt, U., Kruse, F. & Koizumi, N., Jul 1 2019, In : Cornea. 38, 7, p. 799-805 7 p.

Research output: Contribution to journalArticle

Fuchs' Endothelial Dystrophy
Trinucleotide Repeat Expansion
Trinucleotide Repeats
Transcription Factors
Single Nucleotide Polymorphism

Effect of Trinucleotide Repeat Expansion on the Expression of TCF4 mRNA in Fuchs' Endothelial Corneal Dystrophy

Okumura, N., Hayashi, R., Nakano, M., Yoshii, K., Tashiro, K., Sato, T., Blake, D. J., Aleff, R., Butz, M., Highsmith, W. E. J., Wieben, E. D., Fautsch, M. P., Baratz, K., Komori, Y., Nakahara, M., Tourtas, T., Schlötzer-Schrehardt, U., Kruse, F. & Koizumi, N., Feb 1 2019, In : Investigative ophthalmology & visual science. 60, 2, p. 779-786 8 p.

Research output: Contribution to journalArticle

Open Access
Fuchs' Endothelial Dystrophy
Trinucleotide Repeat Expansion
Transcription Factors
Messenger RNA
Corneal Endothelium
2018
2 Citations (Scopus)

Epitope mapping of commercial antibodies that detect myocilin

Patterson-Orazem, A. C., Hill, S. E., Fautsch, M. P. & Lieberman, R. L., Aug 1 2018, In : Experimental Eye Research. 173, p. 109-112 4 p.

Research output: Contribution to journalArticle

Epitope Mapping
Antibodies
Trabecular Meshwork
Epitopes
Ocular Physiological Phenomena
2 Citations (Scopus)

Fuchs’ endothelial corneal dystrophy in patients with myotonic dystrophy, Type 1

Winkler, N. S., Milone, M., Martinez-Thompson, J. M., Raja, H., Aleff, R. A., Patel, S. V., Fautsch, M. P., Wieben, E. D. & Baratz, K., Jun 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 7, p. 3053-3057 5 p.

Research output: Contribution to journalArticle

Fuchs' Endothelial Dystrophy
Myotonic Dystrophy
Trinucleotide Repeat Expansion
Transcription Factors
Protein Kinases

Gene expression in the corneal endothelium of fuchs endothelial corneal dystrophy patients with and without expansion of a trinucleotide repeat in TCF4

Wieben, E. D., Aleff, R. A., Tang, X., Kalari, K. R., Maguire, L. J., Patel, S. V., Baratz, K. & Fautsch, M. P., Jul 1 2018, In : PLoS One. 13, 7, e0200005.

Research output: Contribution to journalArticle

Fuchs' Endothelial Dystrophy
Trinucleotide Repeat Expansion
Trinucleotide Repeats
Corneal Endothelium
endothelium
2 Citations (Scopus)

Interventionelle und pharmakologische Behandlungsansätze für Fuchs-Endotheldystrophie

Translated title of the contribution: Medical and Semi-surgical Treatments for Fuchs Endothelial Corneal DystrophyWacker, K., Baratz, K., Fautsch, M. P. & Patel, S. V., May 3 2018, (Accepted/In press) In : Klinische Monatsblatter fur Augenheilkunde.

Research output: Contribution to journalArticle

Fuchs' Endothelial Dystrophy
Descemet Membrane
Autologous Transplantation
Tissue Donors
Clinical Trials
8 Citations (Scopus)

Repeat-associated non-ATG (RAN) translation in fuchs’ endothelial corneal dystrophy

Soragni, E., Petrosyan, L., Rinkoski, T. A., Wieben, E. D., Baratz, K., Fautsch, M. P. & Gottesfeld, J. M., Apr 1 2018, In : Investigative Ophthalmology and Visual Science. 59, 5, p. 1888-1896 9 p.

Research output: Contribution to journalArticle

Fuchs' Endothelial Dystrophy
Transcription Factors
Corneal Endothelium
Fluorescent Antibody Technique
Trinucleotide Repeat Expansion
2017
2 Citations (Scopus)

ATP-sensitive potassium (KATP) channel openers diazoxide and nicorandil lower intraocular pressure by activating the Erk1/2 signaling pathway

Chowdhury, U. R., Bahler, C. K., Holman, B. H. & Fautsch, M. P., Jun 1 2017, In : PLoS One. 12, 6, e0179345.

Research output: Contribution to journalArticle

diazoxide
Nicorandil
Diazoxide
KATP Channels
potassium channels
1 Citation (Scopus)

Differential Intraocular Pressure Measurements by Tonometry and Direct Cannulation after Treatment with Soluble Adenylyl Cyclase Inhibitors

Gandhi, J. K., Roy Chowdhury, U., Manzar, Z., Buck, J., Levin, L. R., Fautsch, M. P. & Marmorstein, A. D., Oct 1 2017, In : Journal of Ocular Pharmacology and Therapeutics. 33, 8, p. 574-581 8 p.

Research output: Contribution to journalArticle

Manometry
Acepromazine
Intraocular Pressure
Catheterization
Xylazine
2 Citations (Scopus)

Effect of cromakalim prodrug 1 (CKLP1) on aqueous humor dynamics and feasibility of combination therapy with existing ocular hypotensive agents

Chowdhury, U. R., Rinkoski, T. A., Bahler, C. K., Millar, J. C., Bertrand, J. A., Holman, B. H., Sherwood, J. M., Overby, D. R., Stoltz, K. L., Dosa, P. I. & Fautsch, M. P., Nov 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 13, p. 5731-5742 12 p.

Research output: Contribution to journalArticle

Cromakalim
Aqueous Humor
Prodrugs
latanoprost
Timolol
2 Citations (Scopus)

Long-term photoreceptor rescue in two rodent models of retinitis pigmentosa by adeno-associated virus delivery of Stanniocalcin-1

Roddy, G. W., Yasumura, D., Matthes, M. T., Alavi, M. V., Boye, S. L., Rosa, R. H., Fautsch, M. P., Hauswirth, W. W. & LaVail, M. M., Dec 1 2017, In : Experimental Eye Research. 165, p. 175-181 7 p.

Research output: Contribution to journalArticle

Dependovirus
Retinitis Pigmentosa
Rodentia
Retinal Degeneration
Electroretinography
5 Citations (Scopus)

Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure-Lowering Effects of Latanoprost

Roddy, G. W., Viker, K. B., Winkler, N. S., Bahler, C. K., Holman, B. H., Sheikh-Hamad, D., Roy Chowdhury, U., Stamer, W. D. & Fautsch, M. P., May 1 2017, In : Investigative ophthalmology & visual science. 58, 5, p. 2715-2724 10 p.

Research output: Contribution to journalArticle

latanoprost
Intraocular Pressure
Synthetic Prostaglandins
rho-Associated Kinases
teleocalcin
24 Citations (Scopus)

Trinucleotide repeat expansion in the transcription factor 4 (TCF4) gene leads to widespread mrna splicing changes in fuchs’ endothelial corneal dystrophy

Wieben, E. D., Aleff, R. A., Tang, X., Butz, M. L., Kalari, K. R., Highsmith, W. E. J., Jen, J., Vasmatzis, G., Patel, S. V., Maguire, L. J., Baratz, K. & Fautsch, M. P., Jan 1 2017, In : Investigative Ophthalmology and Visual Science. 58, 1, p. 343-352 10 p.

Research output: Contribution to journalArticle

Fuchs' Endothelial Dystrophy
Trinucleotide Repeat Expansion
Corneal Endothelium
Transcription Factors
Genes
2016
7 Citations (Scopus)

Analogs of the ATP-Sensitive Potassium (KATP) Channel Opener Cromakalim with in Vivo Ocular Hypotensive Activity

Roy Chowdhury, U., Viker, K. B., Stoltz, K. L., Holman, B. H., Fautsch, M. P. & Dosa, P. I., Jul 14 2016, In : Journal of Medicinal Chemistry. 59, 13, p. 6221-6231 11 p.

Research output: Contribution to journalArticle

Cromakalim
KATP Channels
Intraocular Pressure
Phosphates
Aqueous Humor
4 Citations (Scopus)

Analysis of cerebrospinal fluid pressure estimation using formulae derived from clinical data

Fleischman, D., Bicket, A. K., Stinnett, S. S., Berdahl, J. P., Jonas, J. B., Wang, N. L., Fautsch, M. P. & Rand Allingham, R., Oct 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 13, p. 5625-5630 6 p.

Research output: Contribution to journalArticle

Cerebrospinal Fluid Pressure
Population
Spinal Puncture
Beijing
Case-Control Studies
9 Citations (Scopus)

Anatomical variation of human collector channel orifices

Bentley, M. D., Hann, C. R. & Fautsch, M. P., Mar 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 3, p. 1153-1159 7 p.

Research output: Contribution to journalArticle

Lip
Plastic Embedding
Immersion
Electron Scanning Microscopy
Dissection
15 Citations (Scopus)

A porcine anterior segment perfusion and transduction model with direct visualization of the trabecular meshwork

Loewen, R. T., Roy, P., Park, D. B., Jensen, A., Scott, G., Cohen-Karni, D., Fautsch, M. P., Schuman, J. S. & Loewen, N. A., Mar 1 2016, In : Investigative Ophthalmology and Visual Science. 57, 3, p. 1338-1344 7 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Swine
Perfusion
Gravitation
Intraocular Pressure
5 Citations (Scopus)

ATP sensitive potassium channel openers: A new class of ocular hypotensive agents

Roy Chowdhury, U., Dosa, P. I. & Fautsch, M. P., Mar 2 2016, (Accepted/In press) In : Experimental Eye Research.

Research output: Contribution to journalArticle

KATP Channels
Glaucoma
Eye Diseases
Retinal Ganglion Cells
Poisons

ATP sensitive potassium channel openers: A new class of ocular hypotensive agents

Roy Chowdhury, U., Dosa, P. I. & Fautsch, M. P., Jun 15 2016, (Accepted/In press) In : Experimental Eye Research.

Research output: Contribution to journalArticle

KATP Channels
2015
12 Citations (Scopus)
Circadian Rhythm
Intraocular Pressure
Gene Expression
Genes
ARNTL Transcription Factors
24 Citations (Scopus)

Aqueous humor outflow: Dynamics and disease

Chowdhury, U. R., Hann, C. R., Stamer, W. D. & Fautsch, M. P., 2015, In : Investigative Ophthalmology and Visual Science. 56, 5, p. 2993-3003 11 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Aqueous Humor
Intraocular Pressure
Glaucoma
11 Citations (Scopus)

Cerebrospinal fluid pressure trends in diseases associated with primary open-angle glaucoma

Fleischman, D., Berdahl, J., Stinnett, S. S., Fautsch, M. P. & Allingham, R. R., May 1 2015, In : Acta Ophthalmologica. 93, 3, p. e234-e236

Research output: Contribution to journalArticle

Cerebrospinal Fluid Pressure
Ocular Hypertension
Open Angle Glaucoma
Intraocular Pressure
Young Adult
Cromakalim
antihypertensive effect
Potassium Channels
potassium channels
Theoretical Models
7 Citations (Scopus)

Ocular hypotensive effects of the ATP sensitive potassium channel opener cromakalim in human and murine experimental model systems

Chowdhury, U. R., Bahler, C. K., Holman, B. H., Dosa, P. I. & Fautsch, M. P., Nov 4 2015, In : PLoS One. 10, 11, 141783.

Research output: Contribution to journalArticle

Cromakalim
KATP Channels
antihypertensive effect
potassium channels
Intraocular Pressure
20 Citations (Scopus)

Quantitative analysis of three-dimensional fibrillar collagen microstructure within the normal, aged and glaucomatous human optic nerve head

Jones, H. J., Girard, M. J., White, N., Fautsch, M. P., Morgan, J. E., Ethier, C. R. & Albon, J., May 6 2015, In : Journal of the Royal Society Interface. 12, 106, 20150066.

Research output: Contribution to journalArticle

Fibrillar Collagens
Optic Disk
Sclera
Collagen
Optics
14 Citations (Scopus)

Reduction of amyloid-beta levels in mouse eye tissues by intra-vitreally delivered neprilysin

Parthasarathy, R., Chow, K. M., Derafshi, Z., Fautsch, M. P., Hetling, J. R., Rodgers, D. W., Hersh, L. B. & Pepperberg, D. R., Sep 1 2015, In : Experimental Eye Research. 138, p. 134-144 11 p.

Research output: Contribution to journalArticle

Neprilysin
Amyloid
Retinal Diseases
Ocular Physiological Phenomena
Therapeutics
2014
34 Citations (Scopus)

Anatomic changes in Schlemm’s canal and collector channels in normal and primary open-angle glaucoma eyes using low and high perfusion pressures

Hann, C. R., Vercnocke, A. J., Bentley, M. D., Jorgensen, S. M. & Fautsch, M. P., 2014, In : Investigative Ophthalmology and Visual Science. 55, 9, p. 5834-5841 8 p.

Research output: Contribution to journalArticle

Perfusion
Pressure
Primary Open Angle Glaucoma
Anatomy
Software
23 Citations (Scopus)

Effects of prostaglandin analogues on aqueous humor outflow pathways

Winkler, N. S. & Fautsch, M. P., Mar 1 2014, In : Journal of Ocular Pharmacology and Therapeutics. 30, 2-3, p. 102-109 8 p.

Research output: Contribution to journalArticle

Synthetic Prostaglandins
Aqueous Humor
Intraocular Pressure
Glaucoma
Therapeutics
2013
4 Citations (Scopus)

A de novo MYOC mutation detected in juvenile open angle glaucoma associated with reduced myocilin protein in aqueous humor

Kuchtey, J., Chowdhury, U. R., Uptegraft, C. C., Fautsch, M. P. & Kuchtey, R. W., Jun 2013, In : European Journal of Medical Genetics. 56, 6, p. 292-296 5 p.

Research output: Contribution to journalArticle

Aqueous Humor
Open Angle Glaucoma
Mutation
Glaucoma
Proteins
13 Citations (Scopus)

A novel rat model to study the role of intracranial pressure modulation on optic neuropathies

Chowdhury, U. R., Holman, B. H. & Fautsch, M. P., Dec 18 2013, In : PLoS One. 8, 12, e82151.

Research output: Contribution to journalArticle

Optic Nerve Diseases
peripheral nervous system diseases
Intracranial Pressure
optics
Rats
12 Citations (Scopus)

ATP-sensitive potassium (KATP) channel openers diazoxide and nicorandil lower intraocular pressure in vivo

Chowdhury, U. R., Holman, B. H. & Fautsch, M. P., 2013, In : Investigative Ophthalmology and Visual Science. 54, 7, p. 4892-4899 8 p.

Research output: Contribution to journalArticle

Nicorandil
Diazoxide
KATP Channels
Intraocular Pressure
Inbred C57BL Mouse
4 Citations (Scopus)

Increasing intraocular pressure as treatment for papilledema

Fleischman, D., Berdahl, J. P., Fautsch, M. P., Chesnutt, D. A. & Allingham, R. R., Oct 2013, In : Experimental Eye Research. 115, p. 278 1 p.

Research output: Contribution to journalArticle

Cerebrospinal Fluid Pressure
Pseudotumor Cerebri
Weightlessness
Papilledema
Intraocular Pressure
21 Citations (Scopus)

Molecular biomarkers in glaucoma

Seventh ARVO/Pfizer Ophthalmics Research Institute Conference Working Group, Jan 1 2013, In : Investigative Ophthalmology and Visual Science. 54, 1, p. 121-131 11 p.

Research output: Contribution to journalArticle

Metabolome
Genomics
Genetic Markers
Glaucoma
Proteomics
2012
54 Citations (Scopus)

Body mass index has a linear relationship with cerebrospinal fluid pressure

Berdahl, J. P., Fleischman, D., Zaydlarova, J., Stinnett, S., Rand Allingham, R. & Fautsch, M. P., Mar 2012, In : Investigative Ophthalmology and Visual Science. 53, 3, p. 1422-1427 6 p.

Research output: Contribution to journalArticle

Cerebrospinal Fluid Pressure
Body Mass Index
Intraocular Pressure
Optic Neuritis
Spinal Puncture
46 Citations (Scopus)

Cerebrospinal Fluid Pressure Decreases with Older Age

Fleischman, D., Berdahl, J. P., Zaydlarova, J., Stinnett, S., Fautsch, M. P. & Allingham, R. R., Dec 29 2012, In : PLoS One. 7, 12, e52664.

Research output: Contribution to journalArticle

Cerebrospinal Fluid Pressure
Cerebrospinal fluid
cerebrospinal fluid
glaucoma
Spinal Puncture
3 Citations (Scopus)

Disc swelling and space flight

Berdahl, J., Fleischman, D., Allingham, R. R. & Fautsch, M. P., Jun 2012, In : Ophthalmology. 119, 6, p. 1290 1 p.

Research output: Contribution to journalArticle

Choroid Diseases
Hyperopia
Weightlessness
Space Flight
Papilledema
51 Citations (Scopus)

Second-generation trabecular meshwork bypass stent (istent inject) increases outflow facility in cultured human anterior segments

Bahler, C. K., Hann, C. R., Fjield, T., Haffner, D., Heitzmann, H. & Fautsch, M. P., Jun 2012, In : American Journal of Ophthalmology. 153, 6, p. 1206-1213 8 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Stents
Nose
Electron Scanning Microscopy
Head
2011
17 Citations (Scopus)

ATP-sensitive potassium (K ATP) channel activation decreases intraocular pressure in the anterior chamber of the eye

Roy Chowdhury, U., Bahler, C. K., Hann, C. R., Chang, M., Resch, Z. T., Romero, M. F. & Fautsch, M. P., Aug 2011, In : Investigative Ophthalmology and Visual Science. 52, 9, p. 6435-6442 8 p.

Research output: Contribution to journalArticle

KATP Channels
Anterior Chamber
Intraocular Pressure
Adenosine Triphosphate
Trabecular Meshwork
5 Citations (Scopus)

Author reply

Fleischman, D., Allingham, R. R., Berdahl, J. & Fautsch, M. P., Jun 2011, In : Ophthalmology. 118, 6, p. 1225-1226 2 p.

Research output: Contribution to journalArticle

Open Angle Glaucoma
Intraocular Pressure
Body Mass Index
Incidence
151 Citations (Scopus)

Elastic modulus determination of normal and glaucomatous human trabecular meshwork

Last, J. A., Pan, T., Ding, Y., Reilly, C. M., Keller, K., Acott, T. S., Fautsch, M. P., Murphy, C. J. & Russell, P., Apr 2011, In : Investigative Ophthalmology and Visual Science. 52, 5, p. 2147-2152 6 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Elastic Modulus
Intraocular Pressure
Glaucoma
Aqueous Humor
14 Citations (Scopus)

Expression profile of the matricellular protein osteopontin in primary open-angle glaucoma and the normal human eye

Chowdhury, U. R., Jea, S. Y., Oh, D. J., Rhee, D. J. & Fautsch, M. P., Aug 2011, In : Investigative Ophthalmology and Visual Science. 52, 9, p. 6443-6451 9 p.

Research output: Contribution to journalArticle

Osteopontin
Aqueous Humor
Proteins
latanoprost
Trabecular Meshwork
51 Citations (Scopus)

Imaging the aqueous humor outflow pathway in human eyes by three-dimensional micro-computed tomography (3D micro-CT)

Hann, C. R., Bentley, M. D., Vercnocke, A., Ritman, E. L. & Fautsch, M. P., Feb 2011, In : Experimental Eye Research. 92, 2, p. 104-111 8 p.

Research output: Contribution to journalArticle

Aqueous Humor
Tomography
Perfusion
Immersion
Intraocular Pressure
26 Citations (Scopus)
Elastin
Pressure
Paraffin
Endothelium
Buffers
17 Citations (Scopus)

Transretinal degeneration in ageing human retina: A multiphoton microscopy analysis

Lei, Y., Garrahan, N., Hermann, B., Fautsch, M. P., Johnson, D. H., Hernandez, M. R., Boulton, M. & Morgan, J. E., May 2011, In : British Journal of Ophthalmology. 95, 5, p. 727-730 4 p.

Research output: Contribution to journalArticle

Retina
Microscopy
Retinal Ganglion Cells
Neurons
Retinal Degeneration
2010
21 Citations (Scopus)

Aqueous humor rapidly stimulates myocilin secretion from human trabecular meshwork cells

Resch, Z. T., Hann, C. R., Cook, K. A. & Fautsch, M. P., Dec 2010, In : Experimental Eye Research. 91, 6, p. 901-908 8 p.

Research output: Contribution to journalArticle

Trabecular Meshwork
Aqueous Humor
Eagles
Conditioned Culture Medium
Hot Temperature
16 Citations (Scopus)

Myocilin levels in primary open-angle glaucoma and pseudoexfoliation glaucoma human aqueous humor

Howell, K. G., Vrabel, A. M., Chowdhury, U. R., Stamer, W. D. & Fautsch, M. P., Dec 2010, In : Journal of Glaucoma. 19, 9, p. 569-575 7 p.

Research output: Contribution to journalArticle

Aqueous Humor
Glaucoma
Densitometry
Transforming Growth Factors
trabecular meshwork-induced glucocorticoid response protein
86 Citations (Scopus)

Proteome analysis of human aqueous humor

Chowdhury, U. R., Madden, B. J., Charlesworth, M. C. & Fautsch, M. P., Oct 2010, In : Investigative Ophthalmology and Visual Science. 51, 10, p. 4921-4931 11 p.

Research output: Contribution to journalArticle

Aqueous Humor
Proteome
Proteins
Protein Array Analysis
Gels
2009

Douglas H. Johnson: A tribute

Johnson, M. & Fautsch, M. P., Apr 30 2009, In : Experimental Eye Research. 88, 4, p. 620-630 11 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Open Angle Glaucoma
Ophthalmology
Biomedical Research
66 Citations (Scopus)

Glaucoma-associated myocilin: A better understanding but much more to learn

Resch, Z. T. & Fautsch, M. P., Apr 30 2009, In : Experimental Eye Research. 88, 4, p. 704-712 9 p.

Research output: Contribution to journalArticle

Glaucoma
Intraocular Pressure
Intracellular Space
Extracellular Space
trabecular meshwork-induced glucocorticoid response protein