Michael John Ackerman, MD, PhD, FACC

  • 37897 Citations
  • 107 Scopus h-Index
1991 …2020

Research output per year

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Research Output

Article

Sodium channel mutation in irritable bowel syndrome: Evidence for an ion channelopathy

Saito, Y. A., Strege, P. R., Tester, D. J., Locke, G. R., Talley, N. J., Bernard, C. E., Rae, J. L., Makielski, J. C., Ackerman, M. J. & Farrugia, G., Feb 2009, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 296, 2, p. G211-G218

Research output: Contribution to journalArticle

86 Scopus citations

Spectrum and frequency of cardiac channel defects in swimming-triggered arrhythmia syndromes

Choi, G., Kopplin, L. J., Tester, D. J., Will, M. L., Haglund, C. M. & Ackerman, M. J., Oct 12 2004, In : Circulation. 110, 15, p. 2119-2124 6 p.

Research output: Contribution to journalArticle

187 Scopus citations

Spectrum and prevalence of CALM1-, CALM2-, and CALM3-encoded calmodulin variants in long QT syndrome and functional characterization of a novel long QT syndrome-associated calmodulin missense variant, E141G

Boczek, N. J., Gomez-Hurtado, N., Ye, D., Calvert, M. L., Tester, D. J., Kryshtal, D. O., Hwang, H. S., Johnson, C. N., Chazin, W. J., Loporcaro, C. G., Shah, M., Papez, A. L., Lau, Y. R., Kanter, R., Knollmann, B. C. & Ackerman, M. J., Apr 1 2016, In : Circulation: Cardiovascular Genetics. 9, 2, p. 136-146 11 p.

Research output: Contribution to journalArticle

48 Scopus citations

Spectrum and prevalence of cardiac ryanodine receptor (RyR2) mutations in a cohort of unrelated patients referred explicitly for long QT syndrome genetic testing

Tester, D. J., Kopplin, L. J., Will, M. L. & Ackerman, M. J., Oct 1 2005, In : Heart rhythm. 2, 10, p. 1099-1105 7 p.

Research output: Contribution to journalArticle

112 Scopus citations

Spectrum and prevalence of cardiac sodium channel variants among black, white, Asian, and Hispanic individuals: Implications for arrhythmogenic susceptibility and Brugada/long QT syndrome genetic testing

Ackerman, M. J., Splawski, I., Makielski, J. C., Tester, D. J., Will, M. L., Timothy, K. W., Keating, M. T., Jones, G., Chadha, M., Burrow, C. R., Stephens, J. C., Xu, C., Judson, R. & Curran, M. E., Nov 2004, In : Heart rhythm. 1, 5, p. 600-607 8 p.

Research output: Contribution to journalArticle

231 Scopus citations

Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION® long QT syndrome genetic test

Kapplinger, J. D., Tester, D. J., Salisbury, B. A., Carr, J. L., Harris-Kerr, C., Pollevick, G. D., Wilde, A. A. M. & Ackerman, M. J., Sep 2009, In : Heart rhythm. 6, 9, p. 1297-1303 7 p.

Research output: Contribution to journalArticle

266 Scopus citations

Spectrum and prevalence of mutations involving BrS1- Through BrS12-susceptibility genes in a cohort of unrelated patients referred for brugada syndrome genetic testing: Implications for genetic testing

Crotti, L., Marcou, C. A., Tester, D. J., Castelletti, S., Giudicessi, J. R., Torchio, M., Medeiros-Domingo, A., Simone, S., Will, M. L., Dagradi, F., Schwartz, P. J. & Ackerman, M. J., Oct 9 2012, In : Journal of the American College of Cardiology. 60, 15, p. 1410-1418 9 p.

Research output: Contribution to journalArticle

132 Scopus citations

Stellate ganglion block and cardiac sympathetic denervation in patients with inappropriate sinus tachycardia

Cha, Y. M., Li, X., Yang, M., Han, J., Wu, G., Kapa, S. C., McLeod, C. J., Noseworthy, P. A., Mulpuru, S. K., Asirvatham, S. J., Brady, P. A., Rho, R. H., Friedman, P. A., Lee, H. C., Tian, Y., Zhou, S., Munger, T. M., Ackerman, M. J. & Shen, W. K., Dec 1 2019, In : Journal of cardiovascular electrophysiology. 30, 12, p. 2920-2928 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Stimulant therapy in children with attention-deficit/hyperactivity disorder and concomitant long QT syndrome: A safe combination?

Rohatgi, R. K., Bos, J. M. & Ackerman, M. J., Aug 1 2015, In : Heart rhythm. 12, 8, p. 1807-1812 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Stroke or transient ischemic attack in patients with transvenous pacemaker or defibrillator and echocardiographically detected patent foramen ovale

Desimone, C. V., Friedman, P. A., Noheria, A., Patel, N. A., Desimone, D. C., Bdeir, S., Aakre, C. A., Vaidya, V. R., Slusser, J. P., Hodge, D. O., Ackerman, M. J., Rabinstein, A. A. & Asirvatham, S. J., Sep 24 2013, In : Circulation. 128, 13, p. 1433-1441 9 p.

Research output: Contribution to journalArticle

54 Scopus citations

Subacute perforation of the st. jude riata implantable cardioverter- defibrillator lead: A report of two pediatric cases

Morrison, T. B., Ackerman, M. J. & Rea, R. F., Aug 1 2009, In : Pediatric Cardiology. 30, 6, p. 834-836 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Subclinical cardiomyopathy and long QT syndrome: An echocardiographic observation

Haugaa, K. H., Johnson, J. N., Bos, J. M., Phillips, B. L., Eidem, B. W. & Ackerman, M. J., Jul 1 2013, In : Congenital Heart Disease. 8, 4, p. 352-359 8 p.

Research output: Contribution to journalArticle

12 Scopus citations
5 Scopus citations
4 Scopus citations

Sudden cardiac death in athletes

Semsarian, C., Sweeting, J. & Ackerman, M. J., Mar 18 2015, In : BMJ (Online). 350, h1218.

Research output: Contribution to journalArticle

15 Scopus citations

Sudden cardiac death in athletes

Semsarian, C., Sweeting, J. & Ackerman, M. J., Aug 1 2015, In : British journal of sports medicine. 49, 15, p. 1017-1023 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Sudden infant death syndrome: Do ion channels play a role?

Van Norstrand, D. W. & Ackerman, M. J., Feb 2009, In : Heart rhythm. 6, 2, p. 272-278 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Sudden infant death syndrome-associated mutations in the sodium channel beta subunits

Tan, B. H., Pundi, K. N., Van Norstrand, D. W., Valdivia, C. R., Tester, D. J., Medeiros-Domingo, A., Makielski, J. C. & Ackerman, M. J., Jun 2010, In : Heart rhythm. 7, 6, p. 771-778 8 p.

Research output: Contribution to journalArticle

84 Scopus citations

Suppression of atrial fibrillation with mexiletine pharmacotherapy in a young woman with type 1 long QT syndrome

El Yaman, M., Perry, J., Makielski, J. C. & Ackerman, M. J., Mar 1 2008, In : Heart rhythm. 5, 3, p. 472-474 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

Supraventricular tachycardias, conduction disease, and cardiomyopathy in 3 families with the same rare variant in TNNI3K (p.Glu768Lys)

Podliesna, S., Delanne, J., Miller, L., Tester, D. J., Uzunyan, M., Yano, S., Klerk, M., Cannon, B. C., Khongphatthanayothin, A., Laurent, G., Bertaux, G., Falcon-Eicher, S., Wu, S., Yen, H. Y., Gao, H., Wilde, A. A. M., Faivre, L., Ackerman, M. J., Lodder, E. M. & Bezzina, C. R., Jan 2019, In : Heart rhythm. 16, 1, p. 98-105 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Surgical myectomy improves pulmonary hypertension in obstructive hypertrophic cardiomyopathy

Geske, J. B., Konecny, T., Ommen, S. R., Nishimura, R. A., Sorajja, P., Schaff, H. V., Ackerman, M. J. & Gersh, B. J., Aug 7 2014, In : European heart journal. 35, 30, p. 2032-2039 8 p.

Research output: Contribution to journalArticle

16 Scopus citations

Surgical septal myectomy decreases the risk for appropriate implantable cardioverter defibrillator discharge in obstructive hypertrophic cardiomyopathy

McLeod, C. J., Ommen, S. R., Ackerman, M. J., Weivoda, P. L., Shen, W. K., Dearani, J. A., Schaff, H. V., Tajik, A. J. & Gersh, B. J., Nov 1 2007, In : European heart journal. 28, 21, p. 2583-2588 6 p.

Research output: Contribution to journalArticle

116 Scopus citations

Surgical Ventricular Septal Myectomy for Patients with Noonan Syndrome and Symptomatic Left Ventricular Outflow Tract Obstruction

Poterucha, J. T., Johnson, J. N., O'Leary, P. W., Connolly, H. M., Niaz, T., Maleszewski, J., Ackerman, M. J., Cetta, F., Dearani, J. A. & Eidem, B. W., Oct 1 2015, In : American Journal of Cardiology. 116, 7, p. 1116-1121 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Survival After Myectomy for Obstructive Hypertrophic Cardiomyopathy: What Causes Late Mortality?

Nguyen, A., Schaff, H. V., Nishimura, R. A., Geske, J. B., Ackerman, M. J., Bos, J. M., Dearani, J. & Ommen, S. R., Jan 1 2019, In : Annals of Thoracic Surgery.

Research output: Contribution to journalArticle

6 Scopus citations

Swimming, a gene-specific arrhythmogenic trigger for inherited long QT syndrome

Ackerman, M. J., Tester, D. J. & Porter, B. J., Jan 1 1999, In : Mayo Clinic proceedings. 74, 11, p. 1088-1094 7 p.

Research output: Contribution to journalArticle

197 Scopus citations

Sympathetic nerve activity and simulated diving in healthy humans

Shamsuzzaman, A., Ackerman, M. J., Kuniyoshi, F. S., Accurso, V., Davison, D., Amin, R. S. & Somers, V. K., 2014, In : Autonomic Neuroscience: Basic and Clinical. 181, 1, p. 74-78 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Sympathetic nerve activity in the congenital long-QT syndrome

Shamsuzzaman, A. S. M., Ackerman, M. J., Kara, T., Lanfranchi, P. & Somers, V. K., Apr 15 2003, In : Circulation. 107, 14, p. 1844-1847 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Syncope in children and adolescents and the congenital long QT syndrome

Khositseth, A., Martinez, M. W., Driscoll, D. J. & Ackerman, M. J., Sep 15 2003, In : American Journal of Cardiology. 92, 6, p. 746-749 4 p.

Research output: Contribution to journalArticle

10 Scopus citations

Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex

Ueda, K., Valdivia, C., Medeiros-Domingo, A., Tester, D. J., Vatta, M., Farrugia, G., Ackerman, M. J. & Makielski, J. C., Jul 8 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 27, p. 9355-9360 6 p.

Research output: Contribution to journalArticle

249 Scopus citations

Syntrophin γ2 regulates SCN5A gating by a PDZ domain-mediated interaction

Ou, Y., Strege, P., Miller, S. M., Makielski, J., Ackerman, M., Gibbons, S. J. & Farrugia, G., Jan 17 2003, In : Journal of Biological Chemistry. 278, 3, p. 1915-1923 9 p.

Research output: Contribution to journalArticle

91 Scopus citations

Systems approach to understanding electromechanical activity in the human heart a national heart, lung, and blood institute workshop summary

Rudy, Y., Ackerman, M. J., Bers, D. M., Clancy, C. E., Houser, S. R., London, B., McCulloch, A. D., Przywara, D. A., Rasmusson, R. L., Solaro, J. R., Trayanova, N. A., Van Wagoner, D. R., Varro, A., Weiss, J. N. & Lathrop, D. A., Sep 9 2008, In : Circulation. 118, 11, p. 1202-1211 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Targeted mutational analysis of ankyrin-B in 541 consecutive, unrelated patients referred for long QT syndrome genetic testing and 200 healthy subjects

Sherman, J., Tester, D. J. & Ackerman, M. J., Nov 1 2005, In : Heart rhythm. 2, 11, p. 1218-1223 6 p.

Research output: Contribution to journalArticle

40 Scopus citations

Targeted mutational analysis of the RyR2-encoded cardiac ryanodine receptor in sudden unexplained death: A molecular autopsy of 49 medical examiner/coroner's cases

Tester, D. J., Spoon, D. B., Valdivia, H. H., Makielski, J. C. & Ackerman, M. J., Nov 2004, In : Mayo Clinic proceedings. 79, 11, p. 1380-1384 5 p.

Research output: Contribution to journalArticle

210 Scopus citations

Task force 4: HCM and other cardiomyopathies, mitral valve prolapse, myocarditis, and Marfan syndrome

Maron, B. J., Ackerman, M. J., Nishimura, R. A., Pyeritz, R. E., Towbin, J. A. & Udelson, J. E., Apr 19 2005, In : Journal of the American College of Cardiology. 45, 8, p. 1340-1345 6 p.

Research output: Contribution to journalArticle

202 Scopus citations

Task force 7: Arrhythmias

Zipes, D. P., Ackerman, M. J., Estes, N. A. M., Grant, A. O., Myerburg, R. J. & Van Hare, G., Apr 19 2005, In : Journal of the American College of Cardiology. 45, 8, p. 1354-1363 10 p.

Research output: Contribution to journalArticle

157 Scopus citations
9 Scopus citations

TGFβ inducible early gene-1 (TIEG1) and cardiac hypertrophy: Discovery and characterization of a novel signaling pathway

Rajamannan, N. M., Subramaniam, M., Abraham, T. P., Vasile, V. C., Ackerman, M. J., Monroe, D. G., Chew, T. L. & Spelsberg, T. C., Feb 1 2007, In : Journal of cellular biochemistry. 100, 2, p. 315-325 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

TGFβ-inducible early gene-1 (TIEG1) mutations in hypertrophic cardiomyopathy

Bos, J. M., Subramaniam, M., Hawse, J. R., Christiaans, I., Rajamannan, N. M., Maleszewski, J. J., Edwards, W. D., Wilde, A. A. M., Spelsberg, T. C. & Ackerman, M. J., Jun 2012, In : Journal of cellular biochemistry. 113, 6, p. 1896-1903 8 p.

Research output: Contribution to journalArticle

15 Scopus citations

The common African American polymorphism SCN5A-S1103Y interacts with mutation SCN5A-R680h to increase late Na current

Cheng, J., Tester, D. J., Tan, B. H., Valdivia, C. R., Kroboth, S., Ye, B., January, C. T., Ackerman, M. J. & Makielski, J. C., May 2011, In : Physiological Genomics. 43, 9, p. 461-466 6 p.

Research output: Contribution to journalArticle

20 Scopus citations

The common long-QT syndrome mutation KCNQ1/A341V causes unusually severe clinical manifestations in patients with different ethnic backgrounds: Toward a mutation-specific risk stratification

Crotti, L., Spazzolini, C., Schwartz, P. J., Shimizu, W., Denjoy, I., Schulze-Bahr, E., Zaklyazminskaya, E. V., Swan, H., Ackerman, M. J., Moss, A. J., Wilde, A. A. M., Horie, M., Brink, P. A., Insolia, R., De Ferrari, G. M. & Crimi, G., Nov 1 2007, In : Circulation. 116, 21, p. 2366-2375 10 p.

Research output: Contribution to journalArticle

115 Scopus citations

The diagnostic utility of recovery phase QTc during treadmill exercise stress testing in the evaluation of long QT syndrome

Horner, J. M., Horner, M. M. & Ackerman, M. J., Nov 1 2011, In : Heart rhythm. 8, 11, p. 1698-1704 7 p.

Research output: Contribution to journalArticle

74 Scopus citations

The Effect of Left Cardiac Sympathetic Denervation on Exercise in Patients With Long QT Syndrome

Anderson, H. N., Bos, J. M., Rohatgi, R. K. & Ackerman, M. J., Sep 2019, In : JACC: Clinical Electrophysiology. 5, 9, p. 1084-1090 7 p.

Research output: Contribution to journalArticle

1 Scopus citations

The effect of mitral valve surgery on ventricular arrhythmia in patients with bileaflet mitral valve prolapse

Naksuk, N., Syed, F. F., Krittanawong, C., Anderson, M. J., Ebrille, E., DeSimone, C. V., Vaidya, V. R., Ponamgi, S. P., Suri, R. M., Ackerman, M. J., Nkomo, V. T., Asirvatham, S. J. & Noseworthy, P. A., Nov 1 2016, In : Indian Pacing and Electrophysiology Journal. 16, 6, p. 187-191 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

The molecular autopsy: An indispensable step following sudden cardiac death in the young?

Boczek, N. J., Tester, D. J. & Ackerman, M. J., Sep 2012, In : Herzschrittmachertherapie und Elektrophysiologie. 23, 3, p. 167-173 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

The Natural History of Nonobstructive Hypertrophic Cardiomyopathy

Hebl, V. B., Miranda, W. R., Ong, K. C., Hodge, D. O., Bos, J. M., Gentile, F., Klarich, K. W., Nishimura, R. A., Ackerman, M. J., Gersh, B. J., Ommen, S. R. & Geske, J. B., Mar 1 2016, In : Mayo Clinic Proceedings. 91, 3, p. 279-287 9 p.

Research output: Contribution to journalArticle

14 Scopus citations

The prevalence and diagnostic/prognostic utility of sinus arrhythmia in the evaluation of congenital long QT syndrome

Johnson, J. N. & Ackerman, M. J., Dec 2010, In : Heart rhythm. 7, 12, p. 1785-1789 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

The QT Interval

Giudicessi, J. R., Noseworthy, P. & Ackerman, M. J., Jun 11 2019, In : Circulation. 139, 24, p. 2711-2713 3 p.

Research output: Contribution to journalArticle

6 Scopus citations

The RYR2-Encoded Ryanodine Receptor/Calcium Release Channel in Patients Diagnosed Previously With Either Catecholaminergic Polymorphic Ventricular Tachycardia or Genotype Negative, Exercise-Induced Long QT Syndrome. A Comprehensive Open Reading Frame Mutational Analysis

Medeiros-Domingo, A., Bhuiyan, Z. A., Tester, D. J., Hofman, N., Bikker, H., van Tintelen, J. P., Mannens, M. M. A. M., Wilde, A. A. M. & Ackerman, M. J., Nov 24 2009, In : Journal of the American College of Cardiology. 54, 22, p. 2065-2074 10 p.

Research output: Contribution to journalArticle

198 Scopus citations

Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome

Lahrouchi, N., Tadros, R., Crotti, L., Mizusawa, Y., Postema, P. G., Beekman, L., Walsh, R., Hasegawa, K., Barc, J., Ernsting, M., Turkowski, K. L., Mazzanti, A., Beckmann, B. M., Shimamoto, K., Diamant, U. B., Wijeyeratne, Y. D., Kucho, Y., Robyns, T., Ishikawa, T., Arbelo, E. & 86 others, Christiansen, M., Winbo, A., Jabbari, R., Lubitz, S. A., Steinfurt, J., Rudic, B., Loeys, B., Shoemaker, M. B., Weeke, P. E., Pfeiffer, R., Davies, B., Andorin, A., Hofman, N., Dagradi, F., Pedrazzini, M., Tester, D. J., Bos, J. M., Sarquella-Brugada, G., Campuzano, Ó., Platonov, P. G., Stallmeyer, B., Zumhagen, S., Nannenberg, E. A., Veldink, J. H., van den Berg, L. H., Al-Chalabi, A., Shaw, C. E., Shaw, P. J., Morrison, K. E., Andersen, P. M., Müller-Nurasyid, M., Cusi, D., Barlassina, C., Galan, P., Lathrop, M., Munter, M., Werge, T., Ribasés, M., Aung, T., Khor, C. C., Ozaki, M., Lichtner, P., Meitinger, T., van Tintelen, J. P., Hoedemaekers, Y., Denjoy, I., Leenhardt, A., Napolitano, C., Shimizu, W., Schott, J. J., Gourraud, J. B., Makiyama, T., Ohno, S., Itoh, H., Krahn, A. D., Antzelevitch, C., Roden, D. M., Saenen, J., Borggrefe, M., Odening, K. E., Ellinor, P. T., Tfelt-Hansen, J., Skinner, J. R., van den Berg, M. P., Olesen, M. S., Brugada, J., Brugada, R., Makita, N., Breckpot, J., Yoshinaga, M., Behr, E. R., Rydberg, A., Aiba, T., Kääb, S., Priori, S. G., Guicheney, P., Tan, H. L., Newton-Cheh, C., Ackerman, M. J., Schwartz, P. J., Schulze-Bahr, E., Probst, V., Horie, M., Wilde, A. A., Tanck, M. W. T. & Bezzina, C. R., Jul 28 2020, In : Circulation. 142, 4, p. 324-338 15 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations