Michael John Ackerman, MD, PhD, FACC

  • 36548 Citations
  • 106 Scopus h-Index
1991 …2020

Research output per year

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Research Output

Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization

Beavers, D. L., Wang, W., Ather, S., Voigt, N., Garbino, A., Dixit, S. S., Landstrom, A. P., Li, N., Wang, Q., Olivotto, I., Dobrev, D., Ackerman, M. J. & Wehrens, X. H. T., Nov 19 2013, In : Journal of the American College of Cardiology. 62, 21, p. 2010-2019 10 p.

Research output: Contribution to journalArticle

91 Scopus citations

Mutation in glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias

London, B., Michalec, M., Mehdi, H., Zhu, X., Kerchner, L., Sanyal, S., Viswanathan, P. C., Pfahnl, A. E., Shang, L. L., Madhusudanan, M., Baty, C. J., Lagana, S., Aleong, R., Gutmann, R., Ackerman, M. J., McNamara, D. M., Weiss, R. & Dudley, S. C., Nov 1 2007, In : Circulation. 116, 20, p. 2260-2268 9 p.

Research output: Contribution to journalArticle

342 Scopus citations

Mutation of an A-kinase-anchoring protein causes long-QT syndrome

Chen, L., Marquardt, M. L., Tester, D. J., Sampson, K. J., Ackerman, M. J. & Kass, R. S., Dec 26 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 52, p. 20990-20995 6 p.

Research output: Contribution to journalArticle

236 Scopus citations

Mutations in conserved amino acids in the KCNQ1 channel and risk of cardiac events in type-1 long-QT syndrome

Jons, C., Moss, A. J., Lopes, C. M., McNitt, S., Zareba, W., Goldenberg, I., Qi, M., Wilde, A. A. M., Shimizu, W., Kanters, J. K., Towbin, J. A., Ackerman, M. J. & Robinson, J. L., Aug 1 2009, In : Journal of cardiovascular electrophysiology. 20, 8, p. 859-865 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: Implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome

Barsheshet, A., Goldenberg, I., O-Uchi, J., Moss, A. J., Jons, C., Shimizu, W., Wilde, A. A., McNitt, S., Peterson, D. R., Zareba, W., Robinson, J. L., Ackerman, M. J., Cypress, M., Gray, D. A., Hofman, N., Kanters, J. K., Kaufman, E. S., Platonov, P. G., Qi, M., Towbin, J. A. & 2 others, Vincent, G. M. & Lopes, C. M., Apr 24 2012, In : Circulation. 125, 16, p. 1988-1996 9 p.

Research output: Contribution to journalArticle

117 Scopus citations

Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans

Landstrom, A. P., Weisleder, N., Batalden, K. B., Martijn Bos, J., Tester, D. J., Ommen, S. R., Wehrens, X. H. T., Claycomb, W. C., Ko, J. K., Hwang, M., Pan, Z., Ma, J. & Ackerman, M. J., Jun 1 2007, In : Journal of Molecular and Cellular Cardiology. 42, 6, p. 1026-1035 10 p.

Research output: Contribution to journalArticle

117 Scopus citations

Mutation-Specific Risk in Two Genetic Forms of Type 3 Long QT Syndrome

Liu, J. F., Moss, A. J., Jons, C., Benhorin, J., Schwartz, P. J., Spazzolini, C., Crotti, L., Ackerman, M. J., McNitt, S., Robinson, J. L., Qi, M., Goldenberg, I. & Zareba, W., Jan 15 2010, In : American Journal of Cardiology. 105, 2, p. 210-213 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

Mutation type is not clinically useful in predicting prognosis in hypertrophic cardiomyopathy

Landstrom, A. P. & Ackerman, M. J., Dec 7 2010, In : Circulation. 122, 23, p. 2441-2449 9 p.

Research output: Contribution to journalComment/debate

99 Scopus citations

MY APPROACH to treatment of the congenital long QT syndromes

Ackerman, M. J., Jan 1 2015, In : Trends in cardiovascular medicine. 25, 1, p. 67-69 3 p.

Research output: Contribution to journalComment/debate

8 Scopus citations

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy

McNamara, J. W., Li, A., Lal, S., Bos, J. M., Harris, S. P., Van Der Velden, J., Ackerman, M. J., Cooke, R. & Dos Remedios, C. G., Jun 2017, In : PloS one. 12, 6, e0180064.

Research output: Contribution to journalArticle

32 Scopus citations

My child just fainted: no big deal or sudden-death warning?

Tipton, M. L. & Ackerman, M. J., Jul 2004, In : Emergency medical services. 33, 7, p. 41-45 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy

Olivotto, I., Girolami, F., Ackerman, M. J., Nistri, S., Bos, J. M., Zachara, E., Ommen, S. R., Theis, J. L., Vaubel, R. A., Re, F., Armentano, C., Poggesi, C., Torricelli, F. & Cecchi, F., Jun 2008, In : Mayo Clinic proceedings. 83, 6, p. 630-638 9 p.

Research output: Contribution to journalArticle

256 Scopus citations

Myosin binding protein C mutations and compound heterozygosity in hypertrophic cardiomyopathy

Van Driest, S. L., Vasile, V. C., Ommen, S. R., Will, M. L., Tajik, A. J., Gersh, B. J. & Ackerman, M. J., Nov 2 2004, In : Journal of the American College of Cardiology. 44, 9, p. 1903-1910 8 p.

Research output: Contribution to journalArticle

308 Scopus citations

Neonatal ECG screening: Opinions and facts

Saul, J. P., Schwartz, P. J., Ackerman, M. J. & Triedman, J. K., Mar 1 2015, In : Heart rhythm. 12, 3, p. 610-611 2 p.

Research output: Contribution to journalEditorial

5 Scopus citations

New mammalian chloride channel identified by expression cloning

Paulmichl, M., Li, Y., Wickman, K., Ackerman, M., Peralta, E. & Clapham, D., Jan 1 1992, In : Nature. 356, 6366, p. 238-241 4 p.

Research output: Contribution to journalArticle

297 Scopus citations

Noncardiac genetic predisposition in sudden infant death syndrome

Gray, B., Tester, D. J., Wong, L. C., Chanana, P., Jaye, A., Evans, J. M., Baruteau, A. E., Evans, M., Fleming, P., Jeffrey, I., Cohen, M., Tfelt-Hansen, J., Simpson, M. A., Ackerman, M. J. & Behr, E. R., Mar 1 2019, In : Genetics in Medicine. 21, 3, p. 641-649 9 p.

Research output: Contribution to journalArticle

1 Scopus citations
3 Scopus citations

Noninvasive blood potassium measurement using signal-processed, single-lead ecg acquired from a handheld smartphone

Yasin, O. Z., Attia, Z., Dillon, J. J., DeSimone, C. V., Sapir, Y., Dugan, J., Somers, V., Ackerman, M. J., Asirvatham, S. J., Scott, C. G., Bennet, K. E., Ladewig, D. J., Sadot, D., Geva, A. B. & Friedman, P. A., 2017, (Accepted/In press) In : Journal of Electrocardiology.

Research output: Contribution to journalArticle

5 Scopus citations

Noninvasive potassium determination using a mathematically processed ECG: Proof of concept for a novel "blood-less, blood test"

Dillon, J. J., Desimone, C. V., Sapir, Y., Somers, V. K., Dugan, J. L., Bruce, C. J., Ackerman, M. J., Asirvatham, S. J., Striemer, B. L., Bukartyk, J., Scott, C. G., Bennet, K. E., Mikell, S. B., Ladewig, D. J., Gilles, E. J., Geva, A., Sadot, D. & Friedman, P. A., Jan 1 2015, In : Journal of Electrocardiology. 48, 1, p. 12-18 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Normal electrocardiographic findings: Recognizing physiological adaptations in athletes

Drezner, J. A., Fischbach, P., Froelicher, V., Marek, J., Pelliccia, A., Prutkin, J. M., Schmied, C. M., Sharma, S., Wilson, M. G., Ackerman, M. J., Anderson, J., Ashley, E., Asplund, C. A., Baggish, A. L., Börjesson, M., Cannon, B. C., Corrado, D., DiFiori, J. P., Harmon, K. G., Heidbuchel, H. & 5 others, Owens, D. S., Paul, S., Salerno, J. C., Stein, R. & Vetter, V. L., May 2013, In : Sport en Geneeskunde. 46, 2, p. 24-34 11 p.

Research output: Contribution to journalArticle

Normal electrocardiographic findings: Recognising physiological adaptations in athletes

Drezner, J. A., Fischbach, P., Froelicher, V., Marek, J., Pelliccia, A., Prutkin, J. M., Schmied, C. M., Sharma, S., Wilson, M. G., Ackerman, M. J., Anderson, J., Ashley, E., Asplund, C. A., Baggish, A. L., Börjesson, M., Cannon, B. C., Corrado, D., DiFiori, J. P., Harmon, K. G., Heidbuchel, H. & 5 others, Owens, D. S., Paul, S., Salerno, J. C., Stein, R. & Vetter, V. L., Feb 1 2013, In : British journal of sports medicine. 47, 3, p. 125-136 12 p.

Research output: Contribution to journalArticle

118 Scopus citations

Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: Higher recurrence of events under metoprolol

Chockalingam, P., Crotti, L., Girardengo, G., Johnson, J. N., Harris, K. M., Van Der Heijden, J. F., Hauer, R. N. W., Beckmann, B. M., Spazzolini, C., Rordorf, R., Rydberg, A., Clur, S. A. B., Fischer, M., Van Den Heuvel, F., Kääb, S., Blom, N. A., Ackerman, M. J., Schwartz, P. J. & Wilde, A. A. M., Nov 13 2012, In : Journal of the American College of Cardiology. 60, 20, p. 2092-2099 8 p.

Research output: Contribution to journalArticle

121 Scopus citations

Novel bloodless potassium determination using a signal-processed single-lead ECG

Attia, Z. I., DeSimone, C. V., Dillon, J. J., Sapir, Y., Somers, V., Dugan, J. L., Bruce, C. J., Ackerman, M. J., Asirvatham, S. J., Striemer, B. L., Bukartyk, J., Scott, C. G., Bennet, K. E., Ladewig, D. J., Gilles, E. J., Sadot, D., Geva, A. B. & Friedman, P. A., 2016, In : Journal of the American Heart Association. 5, 1, e002746.

Research output: Contribution to journalArticle

16 Scopus citations

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks

Gomez-Hurtado, N., Boczek, N. J., Kryshtal, D. O., Johnson, C. N., Sun, J., Nitu, F. R., Cornea, R. L., Chazin, W. J., Calvert, M. L., Tester, D. J., Ackerman, M. J. & Knollmann, B. C., Aug 1 2016, In : Circulation: Arrhythmia and Electrophysiology. 9, 8, e004161.

Research output: Contribution to journalArticle

31 Scopus citations

Novel gene and mutation discovery in congenital long QT syndrome: Let's keep looking where the street lamp standeth

Tester, D. J. & Ackerman, M. J., Sep 1 2008, In : Heart rhythm. 5, 9, p. 1282-1284 3 p.

Research output: Contribution to journalEditorial

16 Scopus citations

Novel Junctophilin-2 Mutation A405S Is Associated With Basal Septal Hypertrophy and Diastolic Dysfunction

Quick, A. P., Landstrom, A. P., Wang, Q., Beavers, D. L., Reynolds, J. O., Barreto-Torres, G., Tran, V., Showell, J., Philippen, L. E., Morris, S. A., Skapura, D., Bos, J. M., Pedersen, S. E., Pautler, R. G., Ackerman, M. J. & Wehrens, X. H. T., 2017, In : JACC: Basic to Translational Science. 2, 1, p. 56-67 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Novel long QT syndrome-associated missense mutation, L762F, in CACNA1C-encoded L-type calcium channel imparts a slower inactivation tau and increased sustained and window current

Landstrom, A. P., Boczek, N. J., Ye, D., Miyake, C. Y., De la Uz, C. M., Allen, H. D., Ackerman, M. J. & Kim, J. J., Oct 1 2016, In : International Journal of Cardiology. 220, p. 290-298 9 p.

Research output: Contribution to journalArticle

18 Scopus citations

Novel mechanism for sudden infant death syndrome: Persistent late sodium current secondary to mutations in caveolin-3

Cronk, L. B., Ye, B., Kaku, T., Tester, D. J., Vatta, M., Makielski, J. C. & Ackerman, M. J., Feb 1 2007, In : Heart rhythm. 4, 2, p. 161-166 6 p.

Research output: Contribution to journalArticle

179 Scopus citations

Novel Mutations in the KCND3-Encoded Kv4.3 K+ Channel Associated with Autopsy-Negative Sudden Unexplained Death

Giudicessi, J. R., Ye, D., Kritzberger, C. J., Nesterenko, V. V., Tester, D. J., Antzelevitch, C. & Ackerman, M. J., Jun 1 2012, In : Human mutation. 33, 6, p. 989-997 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms

McKellar, S. H., Tester, D. J., Yagubyan, M., Majumdar, R., Ackerman, M. J. & Sundt, T. M., Aug 1 2007, In : Journal of Thoracic and Cardiovascular Surgery. 134, 2, p. 290-296 7 p.

Research output: Contribution to journalArticle

170 Scopus citations

Novel Timothy syndrome mutation leading to increase in CACNA1C window current

Boczek, N. J., Miller, E. M., Ye, D., Nesterenko, V. V., Tester, D. J., Antzelevitch, C., Czosek, R. J., Ackerman, M. J. & Ware, S. M., Jan 1 2015, In : Heart rhythm. 12, 1, p. 211-219 9 p.

Research output: Contribution to journalArticle

40 Scopus citations

Obstructive hypertrophic cardiomyopathy is associated with reduced expression of vinculin in the intercalated disc

Vasile, V. C., Edwards, W. D., Ommen, S. R. & Ackerman, M. J., Oct 20 2006, In : Biochemical and Biophysical Research Communications. 349, 2, p. 709-715 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Obstructive sleep apnea in patients with congenital long QT syndrome: Implications for increased risk of sudden cardiac death

Shamsuzzaman, A. S., Somers, V., Knilans, T. K., Ackerman, M. J., Wang, Y. & Amin, R. S., Jul 1 2015, In : Sleep. 38, 7, p. 1113-1119 7 p.

Research output: Contribution to journalArticle

24 Scopus citations

Outcome of Patients With Hypertrophic Cardiomyopathy and a Normal Electrocardiogram

McLeod, C. J., Ackerman, M. J., Nishimura, R. A., Tajik, A. J., Gersh, B. J. & Ommen, S. R., Jul 14 2009, In : Journal of the American College of Cardiology. 54, 3, p. 229-233 5 p.

Research output: Contribution to journalArticle

79 Scopus citations

Outcome of septal myectomy for obstructive hypertrophic cardiomyopathy in children and young adults

Altarabsheh, S. E., Dearani, J. A., Burkhart, H. M., Schaff, H. V., Deo, S. V., Eidem, B. W., Ommen, S. R., Li, Z. & Ackerman, M. J., Feb 1 2013, In : Annals of Thoracic Surgery. 95, 2, p. 663-669 7 p.

Research output: Contribution to journalArticle

33 Scopus citations

Outcome of Whole Exome Sequencing for Diagnostic Odyssey Cases of an Individualized Medicine Clinic: The Mayo Clinic Experience

Lazaridis, K. N., Schahl, K. A., Cousin, M. A., Babovic-Vuksanovic, D., Riegert-Johnson, D. L., Gavrilova, R. M., McAllister, T. M., Lindor, N. M., Abraham, R. S., Ackerman, M. J., Pichurin, P. N., Deyle, D. R., Gavrilov, D. K., Hand, J. L., Klee, E. W., Stephens, M. C., Wick, M. J., Atkinson, E. J., Linden, D. R., Ferber, M. J. & 19 others, Wieben, E. D., Farrugia, G., Baudhuin, L. M., Beck, S. A., Beek, G. J., Go, R. S., Guthrie, K. J., Hovan, M. J., Hunt, K. S., Kemppainen, J. L., Kruisselbrink, T. M., McCormick, J. B., McLaughlin, B. M., Murphree, M. I., Niewold, T. B., Oglesbee, D., Reed, A., Thibodeau, S. N. & Thorland, E. C., Mar 1 2016, In : Mayo Clinic Proceedings. 91, 3, p. 297-307 11 p.

Research output: Contribution to journalArticle

58 Scopus citations

Outcomes of lead extraction without subsequent device reimplantation

Al-Hijji, M. A., Killu, A. M., Yousefian, O., Hodge, D. O., Park, J. Y., Hebsur, S., El Sabbagh, A., Pretorius, V. G., Ackerman, M. J., Friedman, P. A., Birgersdotter-Green, U. & Cha, Y-M., 2017, In : Europace. 19, 9, p. 1527-1534 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
47 Scopus citations

Pathogeneses of sudden cardiac death in national collegiate athletic association athletes

Harmon, K. G., Drezner, J. A., Maleszewski, J. J., Lopez-Anderson, M., Owens, D., Prutkin, J. M., Asif, I. M., Klossner, D. & Ackerman, M. J., Apr 2014, In : Circulation: Arrhythmia and Electrophysiology. 7, 2, p. 198-204 7 p.

Research output: Contribution to journalArticle

81 Scopus citations

Pathogenesis of unexplained drowning: New insights from a molecular autopsy

Tester, D. J., Kopplin, L. J., Creighton, W., Burke, A. P. & Ackerman, M. J., May 2005, In : Mayo Clinic proceedings. 80, 5, p. 596-600 5 p.

Research output: Contribution to journalArticle

64 Scopus citations

Pediatric-Onset Arrhythmogenic Cardiomyopathy: Look Right, Look Left, Look Both Ways

Ackerman, M. J. & Giudicessi, J. R., Jul 23 2019, In : Journal of the American College of Cardiology. 74, 3, p. 359-361 3 p.

Research output: Contribution to journalEditorial

Pediatric sudden cardiac arrest

Campbell, R., Berger, S., Ackerman, M. J., Morrow, W. R., Jenkins, K., Minich, L. L. A., Rosenthal, G. L., Snyder, C. S. & Twedell, J., Apr 2012, In : Pediatrics. 129, 4, p. e1094-e1102

Research output: Contribution to journalReview article

29 Scopus citations

Perioperative management of patients with congenital or acquired disorders of the QT interval

O'Hare, M., Maldonado, Y., Munro, J., Ackerman, M. J., Ramakrishna, H. & Sorajja, D., Apr 1 2018, In : British Journal of Anaesthesia. 120, 4, p. 629-644 16 p.

Research output: Contribution to journalReview article

2 Scopus citations

Personalized medicine: genetic diagnosis for inherited cardiomyopathies/channelopathies

Ackerman, M. J., Marcou, C. A. & Tester, D. J., Apr 1 2013, In : Revista Espanola de Cardiologia. 66, 4, p. 298-307 10 p.

Research output: Contribution to journalArticle

24 Scopus citations

Pharmacogenetic issues in thorough QT trials

Judson, R. S., Salisbury, B. A., Reed, C. R. & Ackerman, M. J., Jan 1 2006, In : Molecular Diagnosis and Therapy. 10, 3, p. 153-162 10 p.

Research output: Contribution to journalReview article

10 Scopus citations

Phenotype of Children with QT Prolongation Identified Using an Institution-Wide QT Alert System

Anderson, H. N., Bos, J. M., Haugaa, K. H., Morlan, B. W., Tarrell, R. F., Caraballo, P. & Ackerman, M. J., Oct 22 2015, In : Pediatric Cardiology. 36, 7, p. 1350-1356 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Phylogenetic and physicochemical analyses enhance the classification of rare nonsynonymous single nucleotide variants in type 1 and 2 long-QT syndrome

Giudicessi, J. R., Kapplinger, J. D., Tester, D. J., Alders, M., Salisbury, B. A., Wilde, A. A. M. & Ackerman, M. J., Oct 1 2012, In : Circulation: Cardiovascular Genetics. 5, 5, p. 519-528 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with long-QT syndrome

Sale, H., Wang, J., O'Hara, T. J., Tester, D. J., Phartiyal, P., He, J. Q., Rudy, Y., Ackerman, M. J. & Robertson, G. A., Sep 26 2008, In : Circulation research. 103, 7, p. e81-e95

Research output: Contribution to journalArticle

85 Scopus citations

Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm

Cerrone, M., Montnach, J., Lin, X., Zhao, Y. T., Zhang, M., Agullo-Pascual, E., Leo-Macias, A., Alvarado, F. J., Dolgalev, I., Karathanos, T. V., Malkani, K., Van Opbergen, C. J. M., Van Bavel, J. J. A., Yang, H. Q., Vasquez, C., Tester, D., Fowler, S., Liang, F., Rothenberg, E., Heguy, A. & 7 others, Morley, G. E., Coetzee, W. A., Trayanova, N. A., Ackerman, M. J., Van Veen, T. A. B., Valdivia, H. H. & Delmar, M., Dec 1 2017, In : Nature communications. 8, 1, 106.

Research output: Contribution to journalArticle

34 Scopus citations