Michael John Ackerman, MD, PhD, FACC

  • 35918 Citations
  • 105 Scopus h-Index
1991 …2020

Research output per year

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Research Output

Article

KCNJ2 mutations in arrhythmia patients referred for LQT testing: A mutation T305A with novel effect on rectification properties

Eckhardt, L. L., Farley, A. L., Rodriguez, E., Ruwaldt, K., Hammill, D., Tester, D. J., Ackerman, M. J. & Makielski, J. C., Mar 2007, In : Heart Rhythm. 4, 3, p. 323-329 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

KCNQ1 p.L353L affects splicing and modifies the phenotype in a founder population with long QT syndrome type 1

Kapplinger, J. D., Erickson, A., Asuri, S., Tester, D. J., McIntosh, S., Kerr, C. R., Morrison, J., Tang, A., Sanatani, S., Arbour, L. & Ackerman, M. J., Jun 1 2017, In : Journal of Medical Genetics. 54, 6, p. 390-398 9 p.

Research output: Contribution to journalArticle

6 Scopus citations
3 Scopus citations

Left axis deviation in children without previously known heart disease

Schneider, A. E., Cannon, B. C., Johnson, J. N., Ackerman, M. J. & Wackel, P. L., Mar 1 2018, In : Pediatrics. 141, 3, e20171970.

Research output: Contribution to journalArticle

1 Scopus citations

Left cardiac sympathetic denervation for recurrent ventricular tachyarrhythmias in children with congenital heart disease

Bonura, E. D., Moir, C., Ackerman, M. J. & Wackel, P., Jan 1 2019, In : HeartRhythm Case Reports.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Left cardiac sympathetic denervation for the treatment of long QT syndrome and catecholaminergic polymorphic ventricular tachycardia using video-assisted thoracic surgery

Collura, C. A., Johnson, J. N., Moir, C. & Ackerman, M. J., Jun 2009, In : Heart Rhythm. 6, 6, p. 752-759 8 p.

Research output: Contribution to journalArticle

219 Scopus citations

Left cardiac sympathetic denervation in a pediatric patient with hypertrophic cardiomyopathy and recurrent ventricular fibrillation

Johnson, J. N., Harris, K. M., Moir, C., Lau, Y. R. & Ackerman, M. J., Oct 2011, In : Heart Rhythm. 8, 10, p. 1591-1594 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Left cardiac sympathetic denervation in long QT syndrome: Analysis of therapeutic nonresponders

Bos, J. M., Bos, K. M., Johnson, J. N., Moir, C. & Ackerman, M. J., Aug 2013, In : Circulation: Arrhythmia and Electrophysiology. 6, 4, p. 705-711 7 p.

Research output: Contribution to journalArticle

48 Scopus citations

Left Ventricular Isovolumetric Relaxation Time Is Prolonged in Fetal Long-QT Syndrome

Clur, S. A. B., Vink, A. S., Etheridge, S. P., Robles De Medina, P. G., Rydberg, A., Ackerman, M. J., Wilde, A. A., Blom, N. A., Benson, D. W., Herberg, U., Donofrio, M. T. & Cuneo, B. F., Apr 1 2018, In : Circulation: Arrhythmia and Electrophysiology. 11, 4, e005797.

Research output: Contribution to journalArticle

1 Scopus citations

Left ventricular noncompaction syndrome masquerading or misdiagnosed as congenital long QT syndrome: Remember QT prolongation does not equal long QT syndrome

Coleman, M. A., Bos, J. M., Phillips, S. D., Souza, J. J. & Ackerman, M. J., Sep 2011, In : Congenital Heart Disease. 6, 5, p. 492-498 7 p.

Research output: Contribution to journalArticle

2 Scopus citations

Lidocaine attenuation testing: An in vivo investigation of putative LQT3-associated variants in the SCN5A-encoded sodium channel

Anderson, H. N., Bos, J. M., Kapplinger, J. D., Meskill, J. M., Ye, D. & Ackerman, M. J., 2017, (Accepted/In press) In : Heart Rhythm.

Research output: Contribution to journalArticle

6 Scopus citations

Linking the heart and the brain: Neurodevelopmental disorders in patients with catecholaminergic polymorphic ventricular tachycardia

Lieve, K. V. V., Verhagen, J. M. A., Wei, J., Bos, J. M., van der Werf, C., Rosés i Noguer, F., Mancini, G. M. S., Guo, W., Wang, R., van den Heuvel, F., Frohn-Mulder, I. M. E., Shimizu, W., Nogami, A., Horigome, H., Roberts, J. D., Leenhardt, A., Crijns, H. J. G., Blank, A. C., Aiba, T., Wiesfeld, A. C. P. & 7 others, Blom, N. A., Sumitomo, N., Till, J., Ackerman, M. J., Chen, S. R. W., van de Laar, I. M. B. H. & Wilde, A. A. M., Feb 1 2019, In : Heart Rhythm. 16, 2, p. 220-228 9 p.

Research output: Contribution to journalArticle

2 Scopus citations
7 Scopus citations

Localization and functional consequences of a direct interaction between TRIOBP-1 and hERG proteins in the heart

Jones, D. K., Johnson, A. C., Roti, E. C. R., Liu, F., Uelmen, R., Ayers, R. A., Baczko, I., Tester, D. J., Ackerman, M. J., Trudeau, M. C. & Robertson, G. A., Mar 1 2018, In : Journal of Cell Science. 131, 6, jcs206730.

Research output: Contribution to journalArticle

3 Scopus citations

Localized Structural Alterations Underlying a Subset of Unexplained Sudden Cardiac Death

Haïssaguerre, M., Hocini, M., Cheniti, G., Duchateau, J., Sacher, F., Puyo, S., Cochet, H., Takigawa, M., Denis, A., Martin, R., Derval, N., Bordachar, P., Ritter, P., Ploux, S., Pambrun, T., Klotz, N., Massoullié, G., Pillois, X., Dallet, C., Schott, J. J. & 19 others, Scouarnec, S., Ackerman, M. J., Tester, D., Piot, O., Pasquié, J. L., Leclerc, C., Hermida, J. S., Gandjbakhch, E., Maury, P., Labrousse, L., Coronel, R., Jais, P., Benoist, D., Vigmond, E., Potse, M., Walton, R., Nademanee, K., Bernus, O. & Dubois, R., Jul 1 2018, In : Circulation: Arrhythmia and Electrophysiology. 11, 7, e006120.

Research output: Contribution to journalArticle

11 Scopus citations

Long QT syndrome [1] (multiple letters)

Allan, W. C., Ackerman, M. J. & Porter, C. B. J., 1998, In : Pediatrics. 102, 5, p. 1220-1221 2 p.

Research output: Contribution to journalArticle

3 Scopus citations

Long-QT syndrome after age 40

Goldenberg, I., Moss, A. J., Peterson, D. R., McNitt, S., Zareba, W., Andrews, M. L., Robinson, J. L., Locati, E. H., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Napolitano, C., Priori, S. G., Qi, M., Schwartz, P. J., Towbin, J. A., Vincent, G. M. & Zhang, L., Apr 29 2008, In : Circulation. 117, 17, p. 2192-2201 10 p.

Research output: Contribution to journalArticle

112 Scopus citations

Long QT syndrome and life-threatening anaphylaxis: Is epinephrine safe?

White, J. L., Kahoud, R. J., Li, J. T. C., Campbell, R. L. & Ackerman, M. J., Oct 1 2016, In : Annals of Allergy, Asthma and Immunology. 117, 4, p. 444-446 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Long QT Syndrome and Pregnancy

Seth, R., Moss, A. J., McNitt, S., Zareba, W., Andrews, M. L., Qi, M., Robinson, J. L., Goldenberg, I., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Locati, E. H., Napolitano, C., Priori, S. G., Schwartz, P. J., Towbin, J. A., Vincent, G. M. & Zhang, L., Mar 13 2007, In : Journal of the American College of Cardiology. 49, 10, p. 1092-1098 7 p.

Research output: Contribution to journalArticle

181 Scopus citations
6 Scopus citations

Long QT syndrome-associated mutations in intrauterine fetal death

Crotti, L., Tester, D. J., White, W. M., Bartos, D. C., Insolia, R., Besana, A., Kunic, J. D., Will, M. L., Velasco, E. J., Bair, J. J., Ghidoni, A., Cetin, I., Van Dyke, D. L., Wick, M. J., Brost, B., Delisle, B. P., Facchinetti, F., George, A. L., Schwartz, P. J. & Ackerman, M. J., Apr 10 2013, In : JAMA - Journal of the American Medical Association. 309, 14, p. 1473-1482 10 p.

Research output: Contribution to journalArticle

83 Scopus citations

Long QT syndrome caveolin-3 mutations differentially modulate Kv4 and Cav1.2 channels to contribute to action potential prolongation

Tyan, L., Foell, J. D., Vincent, K. P., Woon, M. T., Mesquitta, W. T., Lang, D., Best, J. M., Ackerman, M. J., McCulloch, A. D., Glukhov, A. V., Balijepalli, R. C. & Kamp, T. J., Jan 1 2019, (Accepted/In press) In : Journal of Physiology.

Research output: Contribution to journalArticle

1 Scopus citations

Long QT syndrome due to a novel mutation in SCN5A: Treatment with ICD placement at 1 month and left cardiac sympathetic denervation at 3 months of age

Silver, E. S., Liberman, L., Chung, W. K., Spotnitz, H. M., Chen, J. M., Ackerman, M. J., Moir, C., Hordof, A. J. & Pass, R. H., Oct 2009, In : Journal of Interventional Cardiac Electrophysiology. 26, 1, p. 41-45 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Long QT Syndrome in Adults

Sauer, A. J., Moss, A. J., McNitt, S., Peterson, D. R., Zareba, W., Robinson, J. L., Qi, M., Goldenberg, I., Hobbs, J. B., Ackerman, M. J., Benhorin, J., Hall, W. J., Kaufman, E. S., Locati, E. H., Napolitano, C., Priori, S. G., Schwartz, P. J., Towbin, J. A., Vincent, G. M. & Zhang, L., Jan 23 2007, In : Journal of the American College of Cardiology. 49, 3, p. 329-337 9 p.

Research output: Contribution to journalArticle

275 Scopus citations

Long QT syndrome type 5-Lite: Defining the clinical phenotype associated with the potentially proarrhythmic p.Asp85Asn-KCNE1 common genetic variant

Lane, C. M., Giudicessi, J. R., Ye, D., Tester, D. J., Rohatgi, R. K., Bos, J. M. & Ackerman, M. J., Jan 1 2018, (Accepted/In press) In : Heart Rhythm.

Research output: Contribution to journalArticle

5 Scopus citations

Long-term effects of surgical septal myectomy on survival in patients with obstructive hypertrophic cardiomyopathy

Ommen, S. R., Maron, B. J., Olivotto, I., Maron, M. S., Cecchi, F., Betocchi, S., Gersh, B. J., Ackerman, M. J., McCully, R. B., Dearani, J. A., Schaff, H. V., Danielson, G. K., Tajik, A. J. & Nishimura, R. A., Aug 2 2005, In : Journal of the American College of Cardiology. 46, 3, p. 470-476 7 p.

Research output: Contribution to journalArticle

457 Scopus citations

Loss-of-Function KCNE2 Variants: True Monogenic Culprits of Long-QT Syndrome or Proarrhythmic Variants Requiring Secondary Provocation?

Roberts, J. D., Krahn, A. D., Ackerman, M. J., Rohatgi, R. K., Moss, A. J., Nazer, B., Tadros, R., Gerull, B., Sanatani, S., Wijeyeratne, Y. D., Baruteau, A. E., Muir, A. R., Pang, B., Cadrin-Tourigny, J., Talajic, M., Rivard, L., Tester, D. J., Liu, T., Whitman, I. R., Wojciak, J. & 12 others, Conacher, S., Gula, L. J., Leong-Sit, P., Manlucu, J., Green, M. S., Hamilton, R., Healey, J. S., Lopes, C. M., Behr, E. R., Wilde, A. A., Gollob, M. H. & Scheinman, M. M., Aug 1 2017, In : Circulation: Arrhythmia and Electrophysiology. 10, 8, e005282.

Research output: Contribution to journalArticle

8 Scopus citations

Loss-of-function mutation of the SCN3B-encoded sodium channel 3 subunit associated with a case of idiopathic ventricular fibrillation

Valdivia, C. R., Medeiros-Domingo, A., Ye, B., Shen, W. K., Algiers, T. J., Ackerman, M. J. & Makielski, J. C., Jun 2010, In : Cardiovascular Research. 86, 3, p. 392-400 9 p.

Research output: Contribution to journalArticle

58 Scopus citations

Loss-of-function mutations in the KCNJ8-Encoded Kir6.1 KATP channel and sudden infant death syndrome

Tester, D. J., Tan, B. H., Medeiros-Domingo, A., Song, C., Makielski, J. C. & Ackerman, M. J., Oct 2011, In : Circulation: Cardiovascular Genetics. 4, 5, p. 510-515 6 p.

Research output: Contribution to journalArticle

47 Scopus citations

Loss of function of hNav1.5 by a ZASP1 mutation associated with intraventricular conduction disturbances in left ventricular noncompaction

Xi, Y., Ai, T., De Lange, E., Li, Z., Wu, G., Brunelli, L., Kyle, W. B., Turker, I., Cheng, J., Ackerman, M. J., Kimura, A., Weiss, J. N., Qu, Z., Kim, J. J., Faulkner, G. & Vatta, M., Oct 2012, In : Circulation: Arrhythmia and Electrophysiology. 5, 5, p. 1017-1026 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Loss-of-function of the voltage-gated sodium channel NaV1.5 (Channelopathies) in patients with irritable bowel syndrome

Beyder, A., Mazzone, A., Strege, P. R., Tester, D. J., Saito Loftus, Y. A., Bernard, C. E., Enders, F. T., Ek, W. E., Schmidt, P. T., Dlugosz, A., Lindberg, G., Karling, P., Ohlsson, B., Gazouli, M., Nardone, G., Cuomo, R., Usai-Satta, P., Galeazzi, F., Neri, M., Portincasa, P. & 8 others, Bellini, M., Barbara, G., Camilleri, M., Locke, G. R., Talley, N. J., D'Amato, M., Ackerman, M. J. & Farrugia, G., 2014, In : Gastroenterology. 146, 7, p. 1659-1668 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Malignant bileaflet mitral valve prolapse syndrome in patients with otherwise idiopathic out-of-hospital cardiac arrest

Sriram, C. S., Syed, F. F., Ferguson, M. E., Johnson, J. N., Sarano, M. E., Cetta, F., Cannon, B. C., Asirvatham, S. J. & Ackerman, M. J., Jul 16 2013, In : Journal of the American College of Cardiology. 62, 3, p. 222-230 9 p.

Research output: Contribution to journalArticle

88 Scopus citations
6 Scopus citations

Marked, transient, emotion-triggered QT accentuation in an adolescent female with type 1 long QT syndrome

Anderson, H. N., Medford, B. A. & Ackerman, M. J., Nov 6 2013, In : Cardiology in the Young. 25, 2, p. 376-379 4 p.

Research output: Contribution to journalArticle

Maternal mosaicism confounds the neonatal diagnosis of type 1 timothy syndrome

Dufendach, K. A., Giudicessi, J. R., Boczek, N. J. & Ackerman, M. J., Jun 2013, In : Pediatrics. 131, 6

Research output: Contribution to journalArticle

17 Scopus citations

Mechanical Dysfunction in Extreme QT Prolongation

Vyas, H., O'Leary, P. W., Earing, M. G., Cetta, F. & Ackerman, M. J., May 2008, In : Journal of the American Society of Echocardiography. 21, 5

Research output: Contribution to journalArticle

14 Scopus citations

Mechanism of loss of Kv11.1 K+ current in mutant T421M-Kv11.1-expressing rat ventricular myocytes: Interaction of trafficking and gating

Balijepalli, S. Y., Lim, E., Concannon, S. P., Chew, C. L., Holzem, K. E., Tester, D. J., Ackerman, M. J., Delisle, B. P., Balijepalli, R. C. & January, C. T., Dec 11 2012, In : Circulation. 126, 24, p. 2809-2818 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Mechanisms of disease: Ion channels - Basic science and clinical disease

Ackerman, M. J. & Clapham, D. E., 1997, In : New England Journal of Medicine. 336, 22, p. 1575-1586 12 p.

Research output: Contribution to journalArticle

284 Scopus citations

Medicina personalizada: diagnóstico genético de cardiopatías/canalopatías hereditarias

Translated title of the contribution: Personalized medicine: Genetic diagnosis for inherited cardiomyopathies/ channelopathiesAckerman, M. J., Marcou, C. A. & Tester, D. J., Apr 2013, In : Revista Espanola de Cardiologia. 66, 4, p. 298-307 10 p.

Research output: Contribution to journalArticle

Mexiletine rescues a mixed biophysical phenotype of the cardiac sodium channel arising from the SCN5a mutation, N406K, found in LQT3 patients

Hu, R. M., Tester, D. J., Li, R., Sun, T., Peterson, B. Z., Ackerman, M. J., Makielski, J. C. & Tan, B. H., Jan 1 2018, In : Channels. 12, 1, p. 176-186 11 p.

Research output: Contribution to journalArticle

Mexiletine Shortens the QT Interval in Patients With Potassium Channel-Mediated Type 2 Long QT Syndrome

Bos, J. M., Crotti, L., Rohatgi, R. K., Castelletti, S., Dagradi, F., Schwartz, P. J. & Ackerman, M. J., May 1 2019, In : Circulation. Arrhythmia and electrophysiology. 12, 5, p. e007280

Research output: Contribution to journalArticle

7 Scopus citations

Microvascular function is selectively impaired in patients with hypertrophic cardiomyopathy and sarcomere myofilament gene mutations

Olivotto, I., Girolami, F., Sciagr, R., Ackerman, M. J., Sotgia, B., Bos, J. M., Nistri, S., Sgalambro, A., Grifoni, C., Torricelli, F., Camici, P. G. & Cecchi, F., Aug 16 2011, In : Journal of the American College of Cardiology. 58, 8, p. 839-848 10 p.

Research output: Contribution to journalArticle

85 Scopus citations

Minimally invasive epicardial implantable cardioverter-defibrillator placement for infants and children: An effective alternative to the transvenous approach

Schneider, A. E., Burkhart, H. M., Ackerman, M. J., Dearani, J. A., Wackel, P. & Cannon, B. C., 2016, (Accepted/In press) In : Heart Rhythm.

Research output: Contribution to journalArticle

5 Scopus citations

Molecular and functional characterization of a human frataxin mutation found in hypertrophic cardiomyopathy

Van Driest, S. L., Gakh, O., Ommen, S. R., Isaya, G. & Ackerman, M. J., Aug 2005, In : Molecular Genetics and Metabolism. 85, 4, p. 280-285 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels

Anson, B. D., Ackerman, M. J., Tester, D. J., Will, M. L., Delisle, B. P., Anderson, C. L. & January, C. T., Jun 2004, In : American Journal of Physiology - Heart and Circulatory Physiology. 286, 6 55-6

Research output: Contribution to journalArticle

108 Scopus citations

Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L) mutations in sudden infant death syndrome

Van Norstrand, D. W., Valdivia, C. R., Tester, D. J., Ueda, K., London, B., Makielski, J. C. & Ackerman, M. J., Nov 2007, In : Circulation. 116, 20, p. 2253-2259 7 p.

Research output: Contribution to journalArticle

140 Scopus citations

Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C

Landstrom, A. P., Parvatiyar, M. S., Pinto, J. R., Marquardt, M. L., Bos, J. M., Tester, D. J., Ommen, S. R., Potter, J. D. & Ackerman, M. J., Aug 2008, In : Journal of Molecular and Cellular Cardiology. 45, 2, p. 281-288 8 p.

Research output: Contribution to journalArticle

75 Scopus citations

Molecular and Functional Characterization of Rare CACNA1C Variants in Sudden Unexplained Death in the Young

Sutphin, B. S., Boczek, N. J., Barajas-Martínez, H., Hu, D., Ye, D., Tester, D. J., Antzelevitch, C. & Ackerman, M. J., Nov 1 2016, In : Congenital Heart Disease. 11, 6, p. 683-692 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

Molecular autopsy of sudden unexplained death in the young

Ackerman, M. J., Tester, D. J. & Driscoll, D. J., 2001, In : American Journal of Forensic Medicine and Pathology. 22, 2, p. 105-111 7 p.

Research output: Contribution to journalArticle

106 Scopus citations

Molecular autopsy vs postmortem genetic testing [3] (multiple letters)

Edwards, W. D. & Ackerman, M. J., 2005, In : Mayo Clinic Proceedings. 80, 9, p. 1234-1236 3 p.

Research output: Contribution to journalArticle

2 Scopus citations