Michael John Ackerman, MD, PhD, FACC

  • 35918 Citations
  • 105 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2012

Drowning

Tester, D. J. & Ackerman, M. J., Aug 23 2012, In : New England Journal of Medicine. 367, 8, p. 777 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Epinephrine test for sudden cardiac death - Is it too early?

Bos, J. M. & Ackerman, M. J., Dec 2012, In : Nature Reviews Cardiology. 9, 12, p. 675-676 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Erratum: HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies (Europace (2011) 13 (1077-1109) DOI: 10.1093/europace/eur245)

Ackerman, M. J., Priori, S. G., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A. J., Ellinor, P. T., Gollob, M., Hamilton, R., Hershberger, R. E., Judge, D. P., Le Marec, H., McKenna, W. J., Schulze-Bahr, E., Semsarian, C., Towbin, J. A., Watkins, H., Wilde, A., Wolpert, C. & 1 others, Zipes, D. P., Feb 2012, In : Europace. 14, 2, p. 277 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

High-risk long QT syndrome mutations in the Kv7.1 (KCNQ1) pore disrupt the molecular basis for rapid K+ permeation

Burgess, D. E., Bartos, D. C., Reloj, A. R., Campbell, K. S., Johnson, J. N., Tester, D. J., Ackerman, M. J., Fressart, V., Denjoy, I., Guicheney, P., Moss, A. J., Ohno, S., Horie, M. & Delisle, B. P., Nov 13 2012, In : Biochemistry. 51, 45, p. 9076-9085 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Loss of function of hNav1.5 by a ZASP1 mutation associated with intraventricular conduction disturbances in left ventricular noncompaction

Xi, Y., Ai, T., De Lange, E., Li, Z., Wu, G., Brunelli, L., Kyle, W. B., Turker, I., Cheng, J., Ackerman, M. J., Kimura, A., Weiss, J. N., Qu, Z., Kim, J. J., Faulkner, G. & Vatta, M., Oct 2012, In : Circulation: Arrhythmia and Electrophysiology. 5, 5, p. 1017-1026 10 p.

Research output: Contribution to journalArticle

19 Scopus citations

Mechanism of loss of Kv11.1 K+ current in mutant T421M-Kv11.1-expressing rat ventricular myocytes: Interaction of trafficking and gating

Balijepalli, S. Y., Lim, E., Concannon, S. P., Chew, C. L., Holzem, K. E., Tester, D. J., Ackerman, M. J., Delisle, B. P., Balijepalli, R. C. & January, C. T., Dec 11 2012, In : Circulation. 126, 24, p. 2809-2818 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations

Purevjav, E., Arimura, T., Augustin, S., Huby, A. C., Takagi, K., Nunoda, S., Kearney, D. L., Taylor, M. D., Terasaki, F., Bos, J. M., Ommen, S. R., Shibata, H., Takahashi, M., Itoh-satoh, M., Mckenna, W. J., Murphy, R. T., Labeit, S., Yamanaka, Y., Machida, N., Park, J. E. & 6 others, Alexander, P. M. A., Weintraub, R. G., Kitaura, Y., Ackerman, M. J., Kimura, A. & Towbin, J. A., May 2012, In : Human Molecular Genetics. 21, 9, p. 2039-2053 15 p., dds022.

Research output: Contribution to journalArticle

49 Scopus citations

Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: Implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome

Barsheshet, A., Goldenberg, I., O-Uchi, J., Moss, A. J., Jons, C., Shimizu, W., Wilde, A. A., McNitt, S., Peterson, D. R., Zareba, W., Robinson, J. L., Ackerman, M. J., Cypress, M., Gray, D. A., Hofman, N., Kanters, J. K., Kaufman, E. S., Platonov, P. G., Qi, M., Towbin, J. A. & 2 others, Vincent, G. M. & Lopes, C. M., Apr 24 2012, In : Circulation. 125, 16, p. 1988-1996 9 p.

Research output: Contribution to journalArticle

117 Scopus citations

Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: Higher recurrence of events under metoprolol

Chockalingam, P., Crotti, L., Girardengo, G., Johnson, J. N., Harris, K. M., Van Der Heijden, J. F., Hauer, R. N. W., Beckmann, B. M., Spazzolini, C., Rordorf, R., Rydberg, A., Clur, S. A. B., Fischer, M., Van Den Heuvel, F., Kääb, S., Blom, N. A., Ackerman, M. J., Schwartz, P. J. & Wilde, A. A. M., Nov 13 2012, In : Journal of the American College of Cardiology. 60, 20, p. 2092-2099 8 p.

Research output: Contribution to journalArticle

118 Scopus citations

Novel Mutations in the KCND3-Encoded Kv4.3 K+ Channel Associated with Autopsy-Negative Sudden Unexplained Death

Giudicessi, J. R., Ye, D., Kritzberger, C. J., Nesterenko, V. V., Tester, D. J., Antzelevitch, C. & Ackerman, M. J., Jun 2012, In : Human Mutation. 33, 6, p. 989-997 9 p.

Research output: Contribution to journalArticle

42 Scopus citations

Pediatric sudden cardiac arrest

Campbell, R., Berger, S., Ackerman, M. J., Morrow, W. R., Jenkins, K., Minich, L. L., Rosenthal, G. L., Snyder, C. S. & Twedell, J., Apr 2012, In : Pediatrics. 129, 4

Research output: Contribution to journalArticle

29 Scopus citations

Phylogenetic and physicochemical analyses enhance the classification of rare nonsynonymous single nucleotide variants in type 1 and 2 long-QT syndrome

Giudicessi, J. R., Kapplinger, J. D., Tester, D. J., Alders, M., Salisbury, B. A., Wilde, A. A. M. & Ackerman, M. J., Oct 2012, In : Circulation: Cardiovascular Genetics. 5, 5, p. 519-528 10 p.

Research output: Contribution to journalArticle

45 Scopus citations

Potassium-channel mutations and cardiac arrhythmias - Diagnosis and therapy

Giudicessi, J. R. & Ackerman, M. J., Jun 2012, In : Nature Reviews Cardiology. 9, 6, p. 319-332 14 p.

Research output: Contribution to journalArticle

58 Scopus citations

Potential depot medroxyprogesterone acetate-triggered torsades de pointes in a case of congenital type 2 long QT syndrome

Giudicessi, J. R., Brost, B. C., Traynor, K. D. & Ackerman, M. J., Jul 2012, In : Heart Rhythm. 9, 7, p. 1143-1147 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel NaV1.5: A novel mechanism of drug action

Beyder, A., Strege, P. R., Reyes, S., Bernard, C. E., Terzic, A., Makielski, J., Ackerman, M. J. & Farrugia, G., Jun 5 2012, In : Circulation. 125, 22, p. 2698-2706 9 p.

Research output: Contribution to journalArticle

50 Scopus citations

Ranolazine inhibits shear sensitivity of endogenous Na+ current and spontaneous action potentials in HL-1 cells

Strege, P., Beyder, A., Bernard, C., Crespo-Diaz, R., Behfar, A., Terzic, A., Ackerman, M. J. & Farrugia, G., Nov 2012, In : Channels. 6, 6, p. 457-462 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Repeat long QT syndrome genetic testing of phenotype-positive cases: Prevalence and etiology of detection misses

Medlock, M. M., Tester, D. J., Will, M. L., Bos, J. M. & Ackerman, M. J., Dec 2012, In : Heart Rhythm. 9, 12, p. 1977-1982 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Restricting sports for athletes with heart disease: Are we saving lives, avoiding lawsuits, or just promoting obesity and sedentary living?

Vaseghi, M., Ackerman, M. J. & Mandapati, R., Mar 2012, In : Pediatric Cardiology. 33, 3, p. 407-416 10 p.

Research output: Contribution to journalArticle

14 Scopus citations

Spectrum and prevalence of mutations involving BrS1- Through BrS12-susceptibility genes in a cohort of unrelated patients referred for brugada syndrome genetic testing: Implications for genetic testing

Crotti, L., Marcou, C. A., Tester, D. J., Castelletti, S., Giudicessi, J. R., Torchio, M., Medeiros-Domingo, A., Simone, S., Will, M. L., Dagradi, F., Schwartz, P. J. & Ackerman, M. J., Oct 9 2012, In : Journal of the American College of Cardiology. 60, 15, p. 1410-1418 9 p.

Research output: Contribution to journalArticle

130 Scopus citations

Surprise, surprise: Idiopathic, isolated complete atrioventricular block may be heritable

Cannon, B. C. & Ackerman, M. J., Sep 18 2012, In : Circulation. 126, 12, p. 1434-1435 2 p.

Research output: Contribution to journalArticle

2 Scopus citations

TGFβ-inducible early gene-1 (TIEG1) mutations in hypertrophic cardiomyopathy

Bos, J. M., Subramaniam, M., Hawse, J. R., Christiaans, I., Rajamannan, N. M., Maleszewski, J., Edwards, W. D., Wilde, A. A. M., Spelsberg, T. C. & Ackerman, M. J., Jun 2012, In : Journal of Cellular Biochemistry. 113, 6, p. 1896-1903 8 p.

Research output: Contribution to journalArticle

14 Scopus citations

The molecular autopsy: An indispensable step following sudden cardiac death in the young?

Boczek, N. J., Tester, D. J. & Ackerman, M. J., Sep 2012, In : Herzschrittmachertherapie und Elektrophysiologie. 23, 3, p. 167-173 7 p.

Research output: Contribution to journalArticle

19 Scopus citations

The molecular autopsy: Should the evaluation continue after the funeral?

Tester, D. J. & Ackerman, M. J., Mar 2012, In : Pediatric Cardiology. 33, 3, p. 461-470 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndrome

Goldenberg, I., Thottathil, P., Lopes, C. M., Moss, A. J., McNitt, S., Jin, O. U., Robinson, J. L., Zareba, W., Ackerman, M. J., Kaufman, E. S., Towbin, J. A., Vincent, M. & Barsheshet, A., Jan 2012, In : Heart Rhythm. 9, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Truncations of titin causing dilated cardiomyopathy

Herman, D. S., Lam, L., Taylor, M. R. G., Wang, L., Teekakirikul, P., Christodoulou, D., Conner, L., DePalma, S. R., McDonough, B., Sparks, E., Teodorescu, D. L., Cirino, A. L., Banner, N. R., Pennell, D. J., Graw, S., Merlo, M., Di Lenarda, A., Sinagra, G., Bos, J. M., Ackerman, M. J. & 9 others, Mitchell, R. N., Murry, C. E., Lakdawala, N. K., Ho, C. Y., Barton, P. J. R., Cook, S. A., Mestroni, L., Seidman, J. G. & Seidman, C. E., Feb 16 2012, In : New England Journal of Medicine. 366, 7, p. 619-628 10 p.

Research output: Contribution to journalArticle

600 Scopus citations

Variants in the 3′ untranslated region of the KCNQ1-encoded K v7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner

Amin, A. S., Giudicessi, J. R., Tijsen, A. J., Spanjaart, A. M., Reckman, Y. J., Klemens, C. A., Tanck, M. W., Kapplinger, J. D., Hofman, N., Sinner, M. F., Mller, M., Wijnen, W. J., Tan, H. L., Bezzina, C. R., Creemers, E. E., Wilde, A. A. M., Ackerman, M. J. & Pinto, Y. M., Mar 2012, In : European Heart Journal. 33, 6, p. 714-723 10 p.

Research output: Contribution to journalArticle

99 Scopus citations
2013

Abnormal electrocardiographic findings in athletes: Recognising changes suggestive of primary electrical disease

Drezner, J. A., Ackerman, M. J., Cannon, B. C., Corrado, D., Heidbuchel, H., Prutkin, J. M., Salerno, J. C., Anderson, J., Ashley, E., Asplund, C. A., Baggish, A. L., Börjesson, M., DiFiori, J. P., Fischbach, P., Froelicher, V., Harmon, K. G., Marek, J., Owens, D. S., Paul, S., Pelliccia, A. & 5 others, Schmied, C. M., Sharma, S., Stein, R., Vetter, V. L. & Wilson, M. G., Feb 2013, In : British Journal of Sports Medicine. 47, 3, p. 153-167 15 p.

Research output: Contribution to journalArticle

86 Scopus citations

Abnormal electrocardiographic findings in athletes: Recognising changes suggestive of cardiomyopathy

Drezner, J. A., Ashley, E., Baggish, A. L., Börjesson, M., Corrado, D., Owens, D. S., Patel, A., Pelliccia, A., Vetter, V. L., Ackerman, M. J., Anderson, J., Asplund, C. A., Cannon, B. C., DiFiori, J., Fischbach, P., Froelicher, V., Harmon, K. G., Heidbuchel, H., Marek, J., Paul, S. & 6 others, Prutkin, J. M., Salerno, J. C., Schmied, C. M., Sharma, S., Stein, R. & Wilson, M., Feb 2013, In : British Journal of Sports Medicine. 47, 3, p. 137-152 16 p.

Research output: Contribution to journalArticle

100 Scopus citations

A KCNQ1 mutation causes a high penetrance for familial atrial fibrillation

Bartos, D. C., Anderson, J. B., Bastiaenen, R., Johnson, J. N., Gollob, M. H., Tester, D. J., Burgess, D. E., Homfray, T., Behr, E. R., Ackerman, M. J., Guicheney, P. & Delisle, B. P., May 2013, In : Journal of Cardiovascular Electrophysiology. 24, 5, p. 562-569 8 p.

Research output: Contribution to journalArticle

32 Scopus citations

Arrhythmia phenotype during fetal life suggests long-QT syndrome genotype: Risk stratification of perinatal long-QT syndrome

Cuneo, B. F., Etheridge, S. P., Horigome, H., Sallee, D., Moon-Grady, A., Weng, H. Y., Ackerman, M. J. & Woodrow Benson, D., Oct 2013, In : Circulation: Arrhythmia and Electrophysiology. 6, 5, p. 946-951 6 p.

Research output: Contribution to journalArticle

25 Scopus citations

Arrhythmia risk in long QT syndrome: Beyond the disease-causative mutation

Giudicessi, J. R. & Ackerman, M. J., Aug 2013, In : Circulation: Cardiovascular Genetics. 6, 4, p. 313-316 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Arrhythmias and arrhythmia management in hypertrophic cardiomyopathy

Martijn Bos, J., Ommen, S. R. & Ackerman, M. J., Jan 1 2013, Electrical Diseases of the Heart: Volume 2: Diagnosis and Treatment, Second Edition. Springer-Verlag London Ltd, p. 7-24 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Arrhythmias and arrhythmia management in hypertrophic cardiomyopathy

Bos, J. M., Ommen, S. R. & Ackerman, M. J., Jul 1 2013, Electrical Diseases of the Heart. Springer-Verlag London Ltd, Vol. 2. p. 7-24 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Azithromycin and risk of sudden cardiac death: Guilty as charged or falsely accused

Giudicessi, J. R. & Ackerman, M. J., Sep 2013, In : Cleveland Clinic Journal of Medicine. 80, 9, p. 539-544 6 p.

Research output: Contribution to journalArticle

16 Scopus citations

Cardiac channelopathies, syncope, and sudden death

Ackerman, M. J., May 30 2013, Moss and Adams' Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult: Eighth Edition. Wolters Kluwer Health Adis (ESP), Vol. 1-2.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cardiac channelopathies and sudden infant death syndrome

Schwartz, P. J., Stramba-Badiale, M., Giudicessi, J. R., Tester, D. J., Crotti, L. & Ackerman, M. J., Jan 1 2013, Electrical Diseases of the Heart: Volume 2: Diagnosis and Treatment, Second Edition. Springer-Verlag London Ltd, p. 381-394 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Caveolin-3 suppresses late sodium current by inhibiting nNOS-dependent S-nitrosylation of SCN5A

Cheng, J., Valdivia, C. R., Vaidyanathan, R., Balijepalli, R. C., Ackerman, M. J. & Makielski, J. C., Aug 2013, In : Journal of Molecular and Cellular Cardiology. 61, p. 102-110 9 p.

Research output: Contribution to journalArticle

37 Scopus citations

Clinical rhythmology: Diagnostic methods and tools

Shen, W. K., Ackerman, M. J., Powell, B. D., Wilde, A. A. M. & Gussak, I., Jan 1 2013, In : Unknown Journal. p. 138-140 3 p.

Research output: Contribution to journalArticle

Congenital long QT syndrome

Tester, D. J., Schwartz, P. J. & Ackerman, M. J., Jan 1 2013, Electrical Diseases of the Heart: Volume 1: Basic Foundations and Primary Electrical Diseases. Springer-Verlag London Ltd, p. 439-468 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Congenital long QT syndrome

Tester, D. J., Schwartz, P. J. & Ackerman, M. J., Mar 1 2013, Electrical Diseases of the Heart. Springer-Verlag London Ltd, Vol. 1. p. 439-468 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Determinants of incomplete penetrance and variable expressivity in heritable cardiac arrhythmia syndromes

Giudicessi, J. R. & Ackerman, M. J., Jan 2013, In : Translational Research. 161, 1, p. 1-14 14 p.

Research output: Contribution to journalArticle

75 Scopus citations

Does low-dose droperidol increase the risk of polymorphic ventricular tachycardia or death in the surgical patient?

Nuttall, G. A., Malone, A. M., Michels, C. A., Trudell, L. C., Renk, T. D., Marienau, M. E. S., Oliver, W. C. & Ackerman, M. J., Feb 2013, In : Anesthesiology. 118, 2, p. 382-386 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Electrical diseases of the heart: Second edition volume 1: Basic foundations and primary electrical diseases

Gussak, I., Antzelevitch, C., Wilde, A. A. M., Powell, B. D., Ackerman, M. J. & Shen, W. K., Jan 1 2013, Springer-Verlag London Ltd. 659 p.

Research output: Book/ReportBook

1 Scopus citations

Electrical diseases of the heart: Volume 2: Diagnosis and treatment, second edition

Gussak, I., Antzelevitch, C., Wilde, A. A. M., Powell, B. D., Ackerman, M. J. & Shen, W. K., Jan 1 2013, Springer-Verlag London Ltd. 682 p.

Research output: Book/ReportBook

1 Scopus citations

Electrical diseases of the heart

Gussak, I., Antzelevitch, C., Wilde, A. A. M., Ackerman, M. J., Powell, B. D. & Shen, W. K., Jul 1 2013, Springer-Verlag London Ltd. 682 p.

Research output: Book/ReportBook

2 Scopus citations

Electrocardiographic interpretation in athletes: The 'Seattle Criteria'

Drezner, J. A., Ackerman, M. J., Anderson, J., Ashley, E., Asplund, C. A., Baggish, A. L., Börjesson, M., Cannon, B. C., Corrado, D., DiFiori, J. P., Fischbach, P., Froelicher, V., Harmon, K. G., Heidbuchel, H., Marek, J., Owens, D. S., Paul, S., Pellicci, A., Prutkin, J. M., Salerno, J. C. & 5 others, Schmied, C. M., Sharma, S., Stein, R., Vetter, V. L. & Wilson, M. G., Feb 2013, In : British Journal of Sports Medicine. 47, 3, p. 122-124 3 p.

Research output: Contribution to journalArticle

343 Scopus citations

Electrocardiographic interpretation in athletes the 'Seattle Criteria'

Drezner, J. A., Ackerman, M. J., Anderson, J., Ashley, E., Asplund, C. A., Baggish, A. L., Börjesson, M., Cannon, B. C., Corrado, D., DiFiori, J. P., Fischbach, P., Froelicher, V., Harmon, K. G., Heldbuchel, H., Marek, J., Owens, D. S., Paul, S., Pelliccia, A., Prutkin, J. M., Salerno, J. C. & 5 others, Schmied, C. M., Sharma, S., Stein, R., Vetter, V. L. & Wilson, M. G., Mar 2013, In : Sport en Geneeskunde. 46, 1, p. 22-25 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes.

Priori, S. G., Wilde, A. A., Horie, M., Cho, Y., Behr, E. R., Berul, C., Blom, N., Brugada, J., Chiang, C. E., Huikuri, H., Kannankeril, P., Krahn, A., Leenhardt, A., Moss, A., Schwartz, P. J., Shimizu, W., Tomaselli, G., Tracy, C., Document Reviewers, R., Ackerman, M. J. & 17 others, Belhassen, B., Estes, N. A. M., Fatkin, D., Kalman, J., Kaufman, E., Kirchhof, P., Schulze-Bahr, E., Wolpert, C., Vohra, J., Refaat, M., Etheridge, S. P., Campbell, R. M., Martin, E. T., Quek, S. C., Heart Rhythm Society, R. S., European Heart Rhythm Association, H. R. A. & Asia Pacific Heart Rhythm Society, P. H. R. S., Oct 2013, In : Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 15, 10, p. 1389-1406 18 p.

Research output: Contribution to journalArticle

295 Scopus citations

Exome sequencing and systems biology converge to identify novel mutations in the L-type calcium channel, CACNA1C, linked to autosomal dominant long QT syndrome

Boczek, N. J., Best, J. M., Tester, D. J., Giudicessi, J. R., Middha, S., Evans, J. M., Kamp, T. J. & Ackerman, M. J., Jun 2013, In : Circulation: Cardiovascular Genetics. 6, 3, p. 279-289 11 p.

Research output: Contribution to journalArticle

63 Scopus citations

FGF12 is a candidate Brugada syndrome locus

Hennessey, J. A., Marcou, C. A., Wang, C., Wei, E. Q., Wang, C., Tester, D. J., Torchio, M., Dagradi, F., Crotti, L., Schwartz, P. J., Ackerman, M. J. & Pitt, G. S., Dec 2013, In : Heart Rhythm. 10, 12, p. 1886-1894 9 p.

Research output: Contribution to journalArticle

51 Scopus citations