Michael John Ackerman, MD, PhD, FACC

  • 35918 Citations
  • 105 Scopus h-Index
1991 …2020

Research output per year

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Research Output

Article

High-risk long QT syndrome mutations in the Kv7.1 (KCNQ1) pore disrupt the molecular basis for rapid K+ permeation

Burgess, D. E., Bartos, D. C., Reloj, A. R., Campbell, K. S., Johnson, J. N., Tester, D. J., Ackerman, M. J., Fressart, V., Denjoy, I., Guicheney, P., Moss, A. J., Ohno, S., Horie, M. & Delisle, B. P., Nov 13 2012, In : Biochemistry. 51, 45, p. 9076-9085 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Histologic characterization of hypertrophic cardiomyopathy with and without myofilament mutations

McLeod, C. J., Bos, J. M., Theis, J. L., Edwards, W. D., Gersh, B. J., Ommen, S. R. & Ackerman, M. J., Nov 2009, In : American Heart Journal. 158, 5, p. 799-805 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Holter monitoring in the evaluation of congenital long QT syndrome

Mauriello, D. A., Johnson, J. N. & Ackerman, M. J., Sep 2011, In : PACE - Pacing and Clinical Electrophysiology. 34, 9, p. 1100-1104 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Homozygous/compound heterozygous triadin mutations associated with autosomal-recessive long-QT syndrome and pediatric sudden cardiac arrest elucidation of the triadin knockout syndrome

Altmann, H. M., Tester, D. J., Will, M. L., Middha, S., Evans, J. M., Eckloff, B. W. & Ackerman, M. J., 2015, In : Circulation. 131, 23, p. 2051-2060 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies

Ackerman, M. J., Priori, S. G., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A. J., Ellinor, P. T., Gollob, M., Hamilton, R., Hershberger, R. E., Judge, D. P., Le Marec, H., McKenna, W. J., Schulze-Bahr, E., Semsarian, C., Towbin, J. A., Watkins, H., Wilde, A., Wolpert, C. & 2 others, Zipes, D. P. & Olson, S., Aug 2011, In : Europace. 13, 8, p. 1077-1109 33 p.

Research output: Contribution to journalArticle

436 Scopus citations

HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: This document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA)

Ackerman, M. J., Priori, S. G., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A. J., Ellinor, P. T., Gollob, M., Hamilton, R., Hershberger, R. E., Judge, D. P., Le Marec, H., McKenna, W. J., Schulze-Bahr, E., Semsarian, C., Towbin, J. A., Watkins, H., Wilde, A., Wolpert, C. & 1 others, Zipes, D. P., Aug 2011, In : Heart Rhythm. 8, 8, p. 1308-1339 32 p.

Research output: Contribution to journalArticle

602 Scopus citations

HRS policy statement: Clinical cardiac electrophysiology fellowship curriculum: Update 2011

Link, M. S., Exner, D. V., Anderson, M., Ackerman, M. J., Al-Ahmad, A., Knight, B. P., Markowitz, S. M., Kaufman, E. S., Haines, D., Asirvatham, S. J., Callans, D. J., Mounsey, J. P., Bogun, F., Narayan, S. M., Krahn, A. D., Mittal, S., Singh, J., Fisher, J. D. & Chugh, S. S., Aug 2011, In : Heart Rhythm. 8, 8, p. 1340-1356 17 p.

Research output: Contribution to journalArticle

9 Scopus citations

Human Fibrinogen for Maintenance and Differentiation of Induced Pluripotent Stem Cells in Two Dimensions and Three Dimensions

Gandhi, J. K., Knudsen, T., Hill, M., Roy, B., Bachman, L., Pfannkoch-Andrews, C., Schmidt, K. N., Metko, M. M., Ackerman, M. J., Resch, Z., Pulido, J. S. & Marmorstein, A. D., Jan 1 2019, In : Stem Cells Translational Medicine.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Hypertrophic cardiomyopathy, athlete's heart, or both: A case of hypertrophic cardiomyopathy regression

Kebed, K. Y., Bos, J. M., Anavekar, N. S., Mulvagh, S. L., Ackerman, M. J. & Ommen, S. R., May 1 2015, In : Circulation: Cardiovascular Imaging. 8, 7, e003312.

Research output: Contribution to journalArticle

2 Scopus citations

Hypotonicity activates a native chloride current in Xenopus oocytes

Ackerman, M. J., Wickman, K. D. & Clapham, D. E., Feb 1994, In : Journal of General Physiology. 103, 2, p. 153-179 27 p.

Research output: Contribution to journalArticle

201 Scopus citations

Identification and Functional Characterization of a Novel CACNA1C -Mediated Cardiac Disorder Characterized by Prolonged QT Intervals with Hypertrophic Cardiomyopathy, Congenital Heart Defects, and Sudden Cardiac Death

Boczek, N. J., Ye, D., Jin, F., Tester, D. J., Huseby, A., Bos, J. M., Johnson, A. J., Kanter, R. & Ackerman, M. J., Oct 1 2015, In : Circulation: Arrhythmia and Electrophysiology. 8, 5, p. 1122-1132 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Identification of a common genetic substrate underlying postpartum cardiac events in congenital long QT syndrome

Khositseth, A., Tester, D. J., Will, M. L., Bell, C. M. & Ackerman, M. J., May 2004, In : Heart Rhythm. 1, 1, p. 60-64 5 p.

Research output: Contribution to journalArticle

82 Scopus citations

Identification of a family with inherited long QT syndrome after a pediatric near-drowning

Ackerman, M. J. & Porter, C. B. J., 1998, In : Pediatrics. 101, 2, p. 306-308 3 p.

Research output: Contribution to journalArticle

26 Scopus citations

Identification of a metavinculin missense mutation, R975W, associated with both hypertrophic and dilated cardiomyopathy

Vasile, V. C., Will, M. L., Ommen, S. R., Edwards, W. D., Olson, T. M. & Ackerman, M. J., Feb 2006, In : Molecular Genetics and Metabolism. 87, 2, p. 169-174 6 p.

Research output: Contribution to journalArticle

75 Scopus citations

Identification of a Novel Homozygous Multi-Exon Duplication in RYR2 among Children with Exertion-Related Unexplained Sudden Deaths in the Amish Community

Tester, D. J., Bombei, H. M., Fitzgerald, K. K., Giudicessi, J. R., Pitel, B. A., Thorland, E. C., Russell, B. G., Hamrick, S. K., Kim, C. S. J., Haglund-Turnquist, C. M., Johnsrude, C. L., Atkins, D. L., Ochoa Nunez, L. A., Law, I., Temple, J. & Ackerman, M. J., Jan 1 2019, (Accepted/In press) In : JAMA cardiology. p. E1-E6

Research output: Contribution to journalArticle

Identification of a possible pathogenic link between congenital long QT syndrome and epilepsy

Johnson, J. N., Hofman, N., Haglund, C. M., Cascino, G. D., Wilde, A. A. M. & Ackerman, M. J., Jan 20 2009, In : Neurology. 72, 3, p. 224-231 8 p.

Research output: Contribution to journalArticle

166 Scopus citations

Identification of concealed and manifest long QT syndrome using a novel T wave analysis program

Sugrue, A., Noseworthy, P., Kremen, V., Bos, J. M., Qiang, B., Rohatgi, R. K., Sapir, Y., Attia, Z. I., Brady, P., Asirvatham, S. J., Friedman, P. A. & Ackerman, M. J., Jul 1 2016, In : Circulation: Arrhythmia and Electrophysiology. 9, 7

Research output: Contribution to journalArticle

8 Scopus citations

Idiopathic Restrictive Cardiomyopathy in Children and Young Adults

Anderson, H. N., Cetta, F., Driscoll, D. J., Olson, T. M., Ackerman, M. J. & Johnson, J. N., Jan 1 2018, (Accepted/In press) In : American Journal of Cardiology.

Research output: Contribution to journalArticle

2 Scopus citations

Impact of clinical decision support preventing the use of QT-prolonging medications for patients at risk for torsade de pointes

Sorita, A., Bos, J. M., Morlan, B. W., Tarrell, R. F., Ackerman, M. J. & Caraballo, P., 2015, In : Journal of the American Medical Informatics Association. 22, e1, p. e21-e27

Research output: Contribution to journalArticle

17 Scopus citations

Impact of genetics on the clinical management of channelopathies

Schwartz, P. J., Ackerman, M. J., George, A. L. & Wilde, A. A. M., Jul 16 2013, In : Journal of the American College of Cardiology. 62, 3, p. 169-180 12 p.

Research output: Contribution to journalArticle

173 Scopus citations

Impact of Genotype on the Occurrence of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy

Bongini, C., Ferrantini, C., Girolami, F., Coppini, R., Arretini, A., Targetti, M., Bardi, S., Castelli, G., Torricelli, F., Cecchi, F., Ackerman, M. J., Padeletti, L., Poggesi, C. & Olivotto, I., Sep 22 2015, (Accepted/In press) In : American Journal of Cardiology.

Research output: Contribution to journalArticle

8 Scopus citations

Impact of left ventricular hypertrophy on QT prolongation and associated mortality

Haugaa, K. H., Bos, J. M., Borkenhagen, E. J., Tarrell, R. F., Morlan, B. W., Caraballo, P. & Ackerman, M. J., Nov 1 2014, In : Heart Rhythm. 11, 11, p. 1957-1965 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Impact of Septal Myectomy on Left Atrial Volume and Left Ventricular Diastolic Filling Patterns: An Echocardiographic Study of Young Patients with Obstructive Hypertrophic Cardiomyopathy

Menon, S. C., Ackerman, M. J., Ommen, S. R., Cabalka, A. K., Hagler, D. J., O'Leary, P. W., Dearani, J. A., Cetta, F. & Eidem, B. W., Jun 2008, In : Journal of the American Society of Echocardiography. 21, 6, p. 684-688 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Implantable cardioverter-defibrillator explantation for overdiagnosed or overtreated congenital long QT syndrome

Gaba, P., Martijn Bos, J., Cannon, B. C., Cha, Y-M., Friedman, P. A., Asirvatham, S. J. & Ackerman, M. J., Apr 1 2016, In : Heart Rhythm. 13, 4, p. 879-885 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Implantable cardioverter-defibrillators in previously undiagnosed patients with catecholaminergic polymorphic ventricular tachycardia resuscitated from sudden cardiac arrest

Van Der Werf, C., Lieve, K. V., Bos, J. M., Lane, C. M., Denjoy, I., Roses-Noguer, F., Aiba, T., Wada, Y., Ingles, J., Leren, I. S., Rudic, B., Schwartz, P. J., Maltret, A., Sacher, F., Skinner, J. R., Krahn, A. D., Roston, T. M., Tfelt-Hansen, J., Swan, H., Robyns, T. & 17 others, Ohno, S., Roberts, J. D., Van Den Berg, M. P., Kammeraad, J. A., Probst, V., Kannankeril, P. J., Blom, N. A., Behr, E. R., Borggrefe, M., Haugaa, K. H., Semsarian, C., Horie, M., Shimizu, W., Till, J. A., Leenhardt, A., Ackerman, M. J. & Wilde, A. A., Sep 14 2019, In : European heart journal. 40, 35, p. 2953-2961 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

Implantable cardioverter defibrillator therapy for congenital long QT syndrome: A single-center experience

Horner, J. M., Kinoshita, M., Webster, T. L., Haglund, C. M., Friedman, P. A. & Ackerman, M. J., Nov 2010, In : Heart Rhythm. 7, 11, p. 1616-1622 7 p.

Research output: Contribution to journalArticle

65 Scopus citations

Implantable cardioverter-defibrillator use in catecholaminergic polymorphic ventricular tachycardia: A systematic review

Roston, T. M., Jones, K., Hawkins, N. M., Bos, J. M., Schwartz, P. J., Perry, F., Ackerman, M. J., Laksman, Z. W. M., Kaul, P., Lieve, K. V. V., Atallah, J., Krahn, A. D. & Sanatani, S., Dec 1 2018, In : Heart Rhythm. 15, 12, p. 1791-1799 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Importance of Variant Interpretation in Whole-Exome Molecular Autopsy: Population-Based Case Series

Shanks, G. W., Tester, D. J., Ackerman, J. P., Simpson, M. A., Behr, E. R., White, S. M. & Ackerman, M. J., Jun 19 2018, In : Circulation. 137, 25, p. 2705-2715 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Inaccurate diagnosis of Brugada syndrome in a healthy woman based on SCN5A mutation classification

Warring, S. K., Anderson, H. N., Bos, J. M. & Ackerman, M. J., 2017, (Accepted/In press) In : HeartRhythm Case Reports.

Research output: Contribution to journalArticle

2 Scopus citations

Incidence, cause, and comparative frequency of sudden cardiac death in national collegiate athletic association athletes a decade in review

Harmon, K. G., Asif, I. M., Maleszewski, J., Owens, D. S., Prutkin, J. M., Salerno, J. C., Zigman, M. L., Ellenbogen, R., Rao, A. L., Ackerman, M. J. & Drezner, J. A., 2015, In : Circulation. 132, 1, p. 10-19 10 p.

Research output: Contribution to journalArticle

171 Scopus citations

Incidence and Etiology of Sudden Cardiac Arrest and Death in High School Athletes in the United States

Harmon, K. G., Asif, I. M., Maleszewski, J., Owens, D. S., Prutkin, J. M., Salerno, J. C., Zigman, M. L., Ellenbogen, R., Rao, A. L., Ackerman, M. J. & Drezner, J. A., Nov 1 2016, In : Mayo Clinic Proceedings. 91, 11, p. 1493-1502 10 p.

Research output: Contribution to journalArticle

25 Scopus citations
2 Scopus citations

Inherited and de novo mutations in the cardiac actin gene cause hypertrophic cardiomyopathy

Olson, T. M., Doan, T. P., Kishimoto, N. Y., Whitby, F. G., Ackerman, M. J. & Fananapazir, L., 2000, In : Journal of Molecular and Cellular Cardiology. 32, 9, p. 1687-1694 8 p.

Research output: Contribution to journalArticle

165 Scopus citations

Inherited arrhythmias: A National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function

Lehnart, S. E., Ackerman, M. J., Benson, D. W., Brugada, R., Clancy, C. E., Donahue, J. K., George, A. L., Grant, A. O., Groft, S. C., January, C. T., Lathrop, D. A., Lederer, W. J., Makielski, J. C., Mohler, P. J., Moss, A., Nerbonne, J. M., Olson, T. M., Przywara, D. A., Towbin, J. A., Wang, L. H. & 1 others, Marks, A. R., Nov 2007, In : Circulation. 116, 20, p. 2325-2345 21 p.

Research output: Contribution to journalArticle

198 Scopus citations

In reply

Sheeler, R. D., Ackerman, M. J., Richelson, E., Nelson, T. K., Staab, J. P., Tangalos, E. G., Dieser, L. M. & Cunningham, J. L., 2013, In : Mayo Clinic Proceedings. 88, 4, p. 420 1 p.

Research output: Contribution to journalArticle

Institution-wide QT alert system identifies patients with a high risk of mortality

Haugaa, K. H., Bos, J. M., Tarrell, R. F., Morlan, B. W., Caraballo, P. & Ackerman, M. J., 2013, In : Mayo Clinic Proceedings. 88, 4, p. 315-325 11 p.

Research output: Contribution to journalArticle

76 Scopus citations

Interaction with GM130 during HERG ion channel trafficking: Disruption by type 2 congenital long QT syndrome mutations

Roti Roti, E. C., Myers, C. D., Ayers, R. A., Boatman, D. E., Delfosse, S. A., Chan, E. K. L., Ackerman, M. J., January, C. T. & Robertson, G. A., Dec 6 2002, In : Journal of Biological Chemistry. 277, 49, p. 47779-47785 7 p.

Research output: Contribution to journalArticle

61 Scopus citations

International criteria for electrocardiographic interpretation in athletes: Consensus statement

Drezner, J. A., Sharma, S., Baggish, A., Papadakis, M., Wilson, M. G., Prutkin, J. M., Gerche, A. L., Ackerman, M. J., Borjesson, M., Salerno, J. C., Asif, I. M., Owens, D. S., Chung, E. H., Emery, M. S., Froelicher, V. F., Heidbuchel, H., Adamuz, C., Asplund, C. A., Cohen, G., Harmon, K. G. & 13 others, Marek, J. C., Molossi, S., Niebauer, J., Pelto, H. F., Perez, M. V., Riding, N. R., Saarel, T., Schmied, C. M., Shipon, D. M., Stein, R., Vetter, V. L., Pelliccia, A. & Corrado, D., May 1 2017, In : British Journal of Sports Medicine. 51, 9, p. 704-731 28 p.

Research output: Contribution to journalArticle

67 Scopus citations

International recommendations for electrocardiographic interpretation in athletes

Sharma, S., Drezner, J. A., Baggish, A., Papadakis, M., Wilson, M. G., Prutkin, J. M., La Gerche, A., Ackerman, M. J., Borjesson, M., Salerno, J. C., Asif, I. M., Owens, D. S., Chung, E. H., Emery, M. S., Froelicher, V. F., Heidbuchel, H., Adamuz, C., Asplund, C. A., Cohen, G., Harmon, K. G. & 13 others, Marek, J. C., Molossi, S., Niebauer, J., Pelto, H. F., Perez, M. V., Riding, N. R., Saarel, T., Schmied, C. M., Shipon, D. M., Stein, R., Vetter, V. L., Pelliccia, A. & Corrado, D., Apr 21 2018, In : European Heart Journal. 39, 16, p. 1466-1480 15 p.

Research output: Contribution to journalArticle

57 Scopus citations

International Triadin Knockout Syndrome Registry

Clemens, D. J., Tester, D. J., Giudicessi, J. R., Bos, J. M., Rohatgi, R. K., Abrams, D. J., Balaji, S., Crotti, L., Faure, J., Napolitano, C., Priori, S. G., Probst, V., Rooryck-Thambo, C., Roux-Buisson, N., Sacher, F., Schwartz, P. J., Silka, M. J., Walsh, M. A. & Ackerman, M. J., Feb 1 2019, In : Circulation. Genomic and precision medicine. 12, 2, p. e002419

Research output: Contribution to journalArticle

3 Scopus citations

Intragenic suppression of trafficking-defective KCNH2 channels associated with long QT syndrome

Delisle, B. P., Slind, J. K., Kilby, J. A., Anderson, C. L., Anson, B. D., Balijepalli, R. C., Tester, D. J., Ackerman, M. J., Kamp, T. J. & January, C. T., Jul 2005, In : Molecular Pharmacology. 68, 1, p. 233-240 8 p.

Research output: Contribution to journalArticle

19 Scopus citations

In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene

Martins, A. S., Parvatiyar, M. S., Feng, H. Z., Bos, J. M., Gonzalez-Martinez, D., Vukmirovic, M., Turna, R. S., Sanchez-Gonzalez, M. A., Badger, C. D., Zorio, D. A. R., Singh, R. K., Wang, Y., Jin, J. P., Ackerman, M. J. & Pinto, J. R., Oct 1 2015, In : Circulation: Cardiovascular Genetics. 8, 5, p. 653-664 12 p.

Research output: Contribution to journalArticle

22 Scopus citations

Irritable bowel syndrome patients have SCN5A channelopathies that lead to decreased Nav1.5 current and mechanosensitivity

Strege, P. R., Mazzone, A., Bernard, C. E., Neshatian, L., Gibbons, S. J., Saito Loftus, Y. A., Tester, D. J., Calvert, M. L., Mayer, E. A., Chang, L., Ackerman, M. J., Beyder, A. & Farrugia, G., Apr 1 2018, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 314, 4, p. G494-G503

Research output: Contribution to journalArticle

9 Scopus citations

Is sudden unexplained nocturnal death syndrome in Southern China a cardiac sodium channel dysfunction disorder?

Liu, C., Tester, D. J., Hou, Y., Wang, W., Lv, G., Ackerman, M. J., Makielski, J. C. & Cheng, J., Mar 2014, In : Forensic Science International. 236, p. 38-45 8 p.

Research output: Contribution to journalArticle

31 Scopus citations

Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling

Landstrom, A. P., Kellen, C. A., Dixit, S. S., Van Oort, R. J., Garbino, A., Weisleder, N., Ma, J., Wehrens, X. H. T. & Ackerman, M. J., Mar 2011, In : Circulation: Heart Failure. 4, 2, p. 214-223 10 p.

Research output: Contribution to journalArticle

62 Scopus citations

Junctophilin-2 is necessary for T-tubule maturation during mouse heart development

Reynolds, J. O., Chiang, D. Y., Wang, W., Beavers, D. L., Dixit, S. S., Skapura, D. G., Landstrom, A. P., Song, L. S., Ackerman, M. J. & Wehrens, X. H. T., Oct 1 2013, In : Cardiovascular Research. 100, 1, p. 44-53 10 p.

Research output: Contribution to journalArticle

54 Scopus citations

J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

Antzelevitch, C., Yan, G. X., Ackerman, M. J., Borggrefe, M., Corrado, D., Guo, J., Gussak, I., Hasdemir, C., Horie, M., Huikuri, H., Ma, C., Morita, H., Nam, G. B., Sacher, F., Shimizu, W., Viskin, S. & Wilde, A. A. M., Apr 1 2017, In : Europace. 19, 4, p. 665-694 30 p.

Research output: Contribution to journalArticle

61 Scopus citations

J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge. Endorsed by the Asia Pacific Heart Rhythm Society (APHRS), the European Heart Rhythm Association (EHRA), the Heart Rhythm Society (HRS), and the Latin American Society of Cardiac Pacing and Electrophysiology (Sociedad Latinoamericana de Estimulación Cardíaca y Elect

Antzelevitch, C., Yan, G. X., Ackerman, M. J., Borggrefe, M., Corrado, D., Guo, J., Gussak, I., Hasdemir, C., Horie, M., Huikuri, H., Ma, C., Morita, H., Nam, G. B., Sacher, F., Shimizu, W., Viskin, S. & Wilde, A. A. M., 2016, (Accepted/In press) In : Heart Rhythm.

Research output: Contribution to journalArticle

94 Scopus citations

J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge

Antzelevitch, C., Yan, G. X., Ackerman, M. J., Borggrefe, M., Corrado, D., Guo, J., Gussak, I., Hasdemir, C., Horie, M., Huikuri, H., Ma, C., Morita, H., Nam, G. B., Sacher, F., Shimizu, W., Viskin, S. & Wilde, A. A. M., Oct 1 2016, In : Journal of Arrhythmia. 32, 5, p. 315-339 25 p.

Research output: Contribution to journalArticle

56 Scopus citations