Michael John Ackerman, MD, PhD, FACC

  • 35918 Citations
  • 105 Scopus h-Index
1991 …2020

Research output per year

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Research Output

Genetics of hypertrophic cardiomyopathy: One, two, or more diseases?

Bos, J. M., Ommen, S. R. & Ackerman, M. J., May 2007, In : Current Opinion in Cardiology. 22, 3, p. 193-199 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Genetics of long QT syndrome

Tester, D. J. & Ackerman, M. J., Jan 1 2014, In : Methodist DeBakey cardiovascular journal. 10, 1, p. 29-33 5 p.

Research output: Contribution to journalArticle

62 Scopus citations

Genetic testing

Tester, D. J. & Ackerman, M. J., 2008, Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. Springer London, p. 444-458 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Genetic testing

Tester, D. J. & Ackerman, M. J., Jan 1 2013, Electrical Diseases of the Heart: Volume 2: Diagnosis and Treatment, Second Edition. Springer-Verlag London Ltd, p. 315-332 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Genetic testing for cardiac channelopathies: Ten questions regarding clinical considerations for heart rhythm allied professionals

Tester, D. J. & Ackerman, M. J., Jun 2005, In : Heart Rhythm. 2, 6, p. 675-677 3 p.

Research output: Contribution to journalArticle

26 Scopus citations

Genetic testing for long-qt syndrome: Distinguishing pathogenic mutations from benign variants

Kapa, S., Tester, D. J., Salisbury, B. A., Harris-Kerr, C., Pungliya, M. S., Alders, M., Wilde, A. A. M. & Ackerman, M. J., Nov 2009, In : Circulation. 120, 18, p. 1752-1760 9 p.

Research output: Contribution to journalArticle

242 Scopus citations

Genetic testing for potentially lethal, highly treatable inherited cardiomyopathies/channelopathies in clinical practice

Tester, D. J. & Ackerman, M. J., Mar 8 2011, In : Circulation. 123, 9, p. 1021-1037 17 p.

Research output: Contribution to journalArticle

142 Scopus citations
39 Scopus citations

Genetic testing in athletes

Tester, D. J. & Ackerman, M. J., Apr 20 2018, Exercise Risks, Cardiac Arrhythmias and Unusual Problems in Athletes. World Scientific Publishing Co. Pte Ltd, Vol. 3-3. p. 41-74 34 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

30 Scopus citations

Genomic risk factors in sudden infant death syndrome

Van Norstrand, D. W. & Ackerman, M. J., 2010, In : Genome Medicine. 2, 11, 86.

Research output: Contribution to journalArticle

34 Scopus citations

Genomic Triangulation and Coverage Analysis in Whole-Exome Sequencing-Based Molecular Autopsies

Shanks, G. W., Tester, D. J., Nishtala, S., Evans, J. M. & Ackerman, M. J., Oct 1 2017, In : Circulation: Cardiovascular Genetics. 10, 5, e001828.

Research output: Contribution to journalArticle

6 Scopus citations

Genotype- and Phenotype-Guided Management of Congenital Long QT Syndrome

Giudicessi, J. R. & Ackerman, M. J., Oct 2013, In : Current Problems in Cardiology. 38, 10, p. 417-455 39 p.

Research output: Contribution to journalArticle

71 Scopus citations

Genotype-Phenotype Aspects of Type 2 Long QT Syndrome

Shimizu, W., Moss, A. J., Wilde, A. A. M., Towbin, J. A., Ackerman, M. J., January, C. T., Tester, D. J., Zareba, W., Robinson, J. L., Qi, M., Vincent, G. M., Kaufman, E. S., Hofman, N., Noda, T., Kamakura, S., Miyamoto, Y., Shah, S., Amin, V., Goldenberg, I., Andrews, M. L. & 1 others, McNitt, S., Nov 24 2009, In : Journal of the American College of Cardiology. 54, 22, p. 2052-2062 11 p.

Research output: Contribution to journalArticle

168 Scopus citations

Genotype-Phenotype Correlation of SCN5A Mutation for the Clinical and Electrocardiographic Characteristics of Probands with Brugada Syndrome: A Japanese Multicenter Registry

Yamagata, K., Horie, M., Aiba, T., Ogawa, S., Aizawa, Y., Ohe, T., Yamagishi, M., Makita, N., Sakurada, H., Tanaka, T., Shimizu, A., Hagiwara, N., Kishi, R., Nakano, Y., Takagi, M., Makiyama, T., Ohno, S., Fukuda, K., Watanabe, H., Morita, H. & 9 others, Hayashi, K., Kusano, K., Kamakura, S., Yasuda, S., Ogawa, H., Miyamoto, Y., Kapplinger, J. D., Ackerman, M. J. & Shimizu, W., Jun 6 2017, In : Circulation. 135, 23, p. 2255-2270 16 p.

Research output: Contribution to journalArticle

42 Scopus citations

Genotype-Phenotype Correlations in Apical Variant Hypertrophic Cardiomyopathy

Towe, E. C., Bos, J. M., Ommen, S. R., Gersh, B. J. & Ackerman, M. J., May 1 2015, In : Congenital Heart Disease. 10, 3, p. E139-E145

Research output: Contribution to journalArticle

8 Scopus citations

Genotype-phenotype Correlations of Hypertrophic Cardiomyopathy When Diagnosed in Children, Adolescents, and Young Adults

Loar, R. W., Bos, J. M., Will, M. L., Ommen, S. R. & Ackerman, M. J., Nov 1 2015, In : Congenital Heart Disease. 10, 6, p. 529-536 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Genotype-phenotype relationships in congenital long QT syndrome

Ackerman, M. J., Oct 2005, In : Journal of Electrocardiology. 38, 4 SUPPL., p. 64-68 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Genotype-phenotype relationships involving hypertrophic cardiomyopathy-associated mutations in titin, muscle LIM protein, and telethonin

Bos, J. M., Poley, R. N., Ny, M., Tester, D. J., Xu, X. H., Vatta, M., Towbin, J. A., Gersh, B. J., Ommen, S. R. & Ackerman, M. J., May 2006, In : Molecular Genetics and Metabolism. 88, 1, p. 78-85 8 p.

Research output: Contribution to journalArticle

134 Scopus citations

Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndrome

Barsheshet, A., Peterson, D. R., Moss, A. J., Schwartz, P. J., Kaufman, E. S., McNitt, S., Polonsky, S., Buber, J., Zareba, W., Robinson, J. L., Ackerman, M. J., Benhorin, J., Towbin, J. A., Vincent, G. M., Zhang, L. & Goldenberg, I., Aug 2011, In : Heart Rhythm. 8, 8, p. 1207-1213 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Genotypic heterogeneity and phenotypic mimicry among unrelated patients referred for catecholaminergic polymorphic ventricular tachycardia genetic testing

Tester, D. J., Arya, P., Will, M., Haglund, C. M., Farley, A. L., Makielski, J. C. & Ackerman, M. J., Jul 2006, In : Heart Rhythm. 3, 7, p. 800-805 6 p.

Research output: Contribution to journalArticle

95 Scopus citations
74 Scopus citations

Green Tea Catechin Normalizes the Enhanced Ca2+ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy-Associated Mutation in Human Cardiac Troponin i (K206I)

Warren, C. M., Karam, C. N., Wolska, B. M., Kobayashi, T., De Tombe, P. P., Arteaga, G. M., Bos, J. M., Ackerman, M. J. & Solaro, R. J., Dec 1 2015, In : Circulation: Cardiovascular Genetics. 8, 6, p. 765-773 9 p.

Research output: Contribution to journalArticle

12 Scopus citations

gsSKAT: Rapid gene set analysis and multiple testing correction for rare-variant association studies using weighted linear kernels

Larson, N., Mcdonnell, S., Cannon Albright, L., Teerlink, C., Stanford, J., Ostrander, E. A., Isaacs, W. B., Xu, J., Cooney, K. A., Lange, E., Schleutker, J., Carpten, J. D., Powell, I., Bailey-Wilson, J. E., Cussenot, O., Cancel-Tassin, G., Giles, G. G., Macinnis, R. J., Maier, C., Whittemore, A. S. & 12 others, Hsieh, C. L., Wiklund, F., Catolona, W. J., Foulkes, W., Mandal, D., Eeles, R., Kote-Jarai, Z., Ackerman, M. J., Olson, T. M., Klein, C. J., Thibodeau, S. N. & Schaid, D. J., 2017, (Accepted/In press) In : Genetic Epidemiology.

Research output: Contribution to journalArticle

2 Scopus citations

GWAS or Gee Whiz, PSAS or Pshaw: Elucidating the biologic and clinical significance of genetic variation in cardiovascular disease

Landstrom, A. P. & Ackerman, M. J., Dec 2009, In : Heart Rhythm. 6, 12, p. 1751-1753 3 p.

Research output: Contribution to journalArticle

5 Scopus citations

Heart-Rate-Corrected QT Interval Evolution in Premature Infants During the First Week of Life

Ulrich, T. J. B., Ellsworth, M. A., Carey, W. A., Zubair, A. S., MacQueen, B. C., Colby, C. E. & Ackerman, M. J., 2014, In : Pediatric Cardiology. 35, 8, p. 1363-1369 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Heart rate dependence of the QT interval duration: Differences among congenital long QT syndrome subtypes

Němec, J., Buncová, M., Bůlková, V., Hejlik, J., Winter, B., Shen, W. K. & Ackerman, M. J., May 2004, In : Journal of Cardiovascular Electrophysiology. 15, 5, p. 550-556 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Heritability in genetic heart disease: The role of genetic background

Jansweijer, J. A., Van Spaendonck-Zwarts, K. Y., Tanck, M. W. T., Peter Van Tintelen, J., Christiaans, I., Van Der Smagt, J., Vermeer, A., Bos, J. M., Moss, A. J., Swan, H., Priori, S., Rydberg, A., Tfelt-Hansen, J., Ackerman, M. J., Olivotto, I., Charron, P., Gimeno, J. R., Van Den Berg, M., Wilde, A. & Pinto, Y. M., May 1 2019, In : Open Heart. 6, 1, e000929.

Research output: Contribution to journalArticle

Open Access

Heterogeneity of ryanodine receptor dysfunction in a mouse model of catecholaminergic polymorphic ventricular tachycardia

Loaiza, R., Benkusky, N. A., Powers, P. P., Hacker, T., Noujaim, S., Ackerman, M. J., Jalife, J. & Valdivia, H. H., Jan 18 2013, In : Circulation Research. 112, 2, p. 298-308 11 p.

Research output: Contribution to journalArticle

32 Scopus citations

High-risk long QT syndrome mutations in the Kv7.1 (KCNQ1) pore disrupt the molecular basis for rapid K+ permeation

Burgess, D. E., Bartos, D. C., Reloj, A. R., Campbell, K. S., Johnson, J. N., Tester, D. J., Ackerman, M. J., Fressart, V., Denjoy, I., Guicheney, P., Moss, A. J., Ohno, S., Horie, M. & Delisle, B. P., Nov 13 2012, In : Biochemistry. 51, 45, p. 9076-9085 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Histologic characterization of hypertrophic cardiomyopathy with and without myofilament mutations

McLeod, C. J., Bos, J. M., Theis, J. L., Edwards, W. D., Gersh, B. J., Ommen, S. R. & Ackerman, M. J., Nov 2009, In : American Heart Journal. 158, 5, p. 799-805 7 p.

Research output: Contribution to journalArticle

22 Scopus citations

Holter monitoring in the evaluation of congenital long QT syndrome

Mauriello, D. A., Johnson, J. N. & Ackerman, M. J., Sep 2011, In : PACE - Pacing and Clinical Electrophysiology. 34, 9, p. 1100-1104 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Homozygous/compound heterozygous triadin mutations associated with autosomal-recessive long-QT syndrome and pediatric sudden cardiac arrest elucidation of the triadin knockout syndrome

Altmann, H. M., Tester, D. J., Will, M. L., Middha, S., Evans, J. M., Eckloff, B. W. & Ackerman, M. J., 2015, In : Circulation. 131, 23, p. 2051-2060 10 p.

Research output: Contribution to journalArticle

37 Scopus citations

HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies

Ackerman, M. J., Priori, S. G., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A. J., Ellinor, P. T., Gollob, M., Hamilton, R., Hershberger, R. E., Judge, D. P., Le Marec, H., McKenna, W. J., Schulze-Bahr, E., Semsarian, C., Towbin, J. A., Watkins, H., Wilde, A., Wolpert, C. & 2 others, Zipes, D. P. & Olson, S., Aug 2011, In : Europace. 13, 8, p. 1077-1109 33 p.

Research output: Contribution to journalArticle

436 Scopus citations

HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: This document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA)

Ackerman, M. J., Priori, S. G., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A. J., Ellinor, P. T., Gollob, M., Hamilton, R., Hershberger, R. E., Judge, D. P., Le Marec, H., McKenna, W. J., Schulze-Bahr, E., Semsarian, C., Towbin, J. A., Watkins, H., Wilde, A., Wolpert, C. & 1 others, Zipes, D. P., Aug 2011, In : Heart Rhythm. 8, 8, p. 1308-1339 32 p.

Research output: Contribution to journalArticle

602 Scopus citations

HRS policy statement: Clinical cardiac electrophysiology fellowship curriculum: Update 2011

Link, M. S., Exner, D. V., Anderson, M., Ackerman, M. J., Al-Ahmad, A., Knight, B. P., Markowitz, S. M., Kaufman, E. S., Haines, D., Asirvatham, S. J., Callans, D. J., Mounsey, J. P., Bogun, F., Narayan, S. M., Krahn, A. D., Mittal, S., Singh, J., Fisher, J. D. & Chugh, S. S., Aug 2011, In : Heart Rhythm. 8, 8, p. 1340-1356 17 p.

Research output: Contribution to journalArticle

9 Scopus citations

Human Fibrinogen for Maintenance and Differentiation of Induced Pluripotent Stem Cells in Two Dimensions and Three Dimensions

Gandhi, J. K., Knudsen, T., Hill, M., Roy, B., Bachman, L., Pfannkoch-Andrews, C., Schmidt, K. N., Metko, M. M., Ackerman, M. J., Resch, Z., Pulido, J. S. & Marmorstein, A. D., Jan 1 2019, In : Stem Cells Translational Medicine.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Hypertrophic Cardiomyopathies

Bos, J. M., Ommen, S. R. & Ackerman, M. J., 2013, Genomic and Personalized Medicine. Elsevier Inc., Vol. 2. p. 572-586 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hypertrophic cardiomyopathy, athlete's heart, or both: A case of hypertrophic cardiomyopathy regression

Kebed, K. Y., Bos, J. M., Anavekar, N. S., Mulvagh, S. L., Ackerman, M. J. & Ommen, S. R., May 1 2015, In : Circulation: Cardiovascular Imaging. 8, 7, e003312.

Research output: Contribution to journalArticle

2 Scopus citations

Hypertrophic Cardiomyopathy in the Era of Genomic Medicine

Bos, J. M., Ommen, S. R. & Ackerman, M. J., 2009, Genomic and Personalized Medicine, Two-Vol Set. Elsevier Inc., p. 716-728 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hypertrophic Cardiomyopathy in the Era of Genomic Medicine

Bos, J. M. & Ackerman, M. J., Nov 13 2017, Genomic and Precision Medicine: Cardiovascular Disease: Third Edition. Elsevier Inc., p. 103-126 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Hypotonicity activates a native chloride current in Xenopus oocytes

Ackerman, M. J., Wickman, K. D. & Clapham, D. E., Feb 1994, In : Journal of General Physiology. 103, 2, p. 153-179 27 p.

Research output: Contribution to journalArticle

201 Scopus citations

Identification and Functional Characterization of a Novel CACNA1C -Mediated Cardiac Disorder Characterized by Prolonged QT Intervals with Hypertrophic Cardiomyopathy, Congenital Heart Defects, and Sudden Cardiac Death

Boczek, N. J., Ye, D., Jin, F., Tester, D. J., Huseby, A., Bos, J. M., Johnson, A. J., Kanter, R. & Ackerman, M. J., Oct 1 2015, In : Circulation: Arrhythmia and Electrophysiology. 8, 5, p. 1122-1132 11 p.

Research output: Contribution to journalArticle

31 Scopus citations

Identification of a common genetic substrate underlying postpartum cardiac events in congenital long QT syndrome

Khositseth, A., Tester, D. J., Will, M. L., Bell, C. M. & Ackerman, M. J., May 2004, In : Heart Rhythm. 1, 1, p. 60-64 5 p.

Research output: Contribution to journalArticle

82 Scopus citations

Identification of a family with inherited long QT syndrome after a pediatric near-drowning

Ackerman, M. J. & Porter, C. B. J., 1998, In : Pediatrics. 101, 2, p. 306-308 3 p.

Research output: Contribution to journalArticle

26 Scopus citations

Identification of a metavinculin missense mutation, R975W, associated with both hypertrophic and dilated cardiomyopathy

Vasile, V. C., Will, M. L., Ommen, S. R., Edwards, W. D., Olson, T. M. & Ackerman, M. J., Feb 2006, In : Molecular Genetics and Metabolism. 87, 2, p. 169-174 6 p.

Research output: Contribution to journalArticle

75 Scopus citations

Identification of a Novel Homozygous Multi-Exon Duplication in RYR2 among Children with Exertion-Related Unexplained Sudden Deaths in the Amish Community

Tester, D. J., Bombei, H. M., Fitzgerald, K. K., Giudicessi, J. R., Pitel, B. A., Thorland, E. C., Russell, B. G., Hamrick, S. K., Kim, C. S. J., Haglund-Turnquist, C. M., Johnsrude, C. L., Atkins, D. L., Ochoa Nunez, L. A., Law, I., Temple, J. & Ackerman, M. J., Jan 1 2019, (Accepted/In press) In : JAMA cardiology. p. E1-E6

Research output: Contribution to journalArticle

Identification of a possible pathogenic link between congenital long QT syndrome and epilepsy

Johnson, J. N., Hofman, N., Haglund, C. M., Cascino, G. D., Wilde, A. A. M. & Ackerman, M. J., Jan 20 2009, In : Neurology. 72, 3, p. 224-231 8 p.

Research output: Contribution to journalArticle

166 Scopus citations

Identification of concealed and manifest long QT syndrome using a novel T wave analysis program

Sugrue, A., Noseworthy, P., Kremen, V., Bos, J. M., Qiang, B., Rohatgi, R. K., Sapir, Y., Attia, Z. I., Brady, P., Asirvatham, S. J., Friedman, P. A. & Ackerman, M. J., Jul 1 2016, In : Circulation: Arrhythmia and Electrophysiology. 9, 7

Research output: Contribution to journalArticle

8 Scopus citations

Idiopathic Restrictive Cardiomyopathy in Children and Young Adults

Anderson, H. N., Cetta, F., Driscoll, D. J., Olson, T. M., Ackerman, M. J. & Johnson, J. N., Jan 1 2018, (Accepted/In press) In : American Journal of Cardiology.

Research output: Contribution to journalArticle

2 Scopus citations