Michael John Ackerman, MD, PhD, FACC

  • 35999 Citations
  • 105 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2007

TGFβ inducible early gene-1 (TIEG1) and cardiac hypertrophy: Discovery and characterization of a novel signaling pathway

Rajamannan, N. M., Subramaniam, M., Abraham, T. P., Vasile, V. C., Ackerman, M. J., Monroe, D. G., Chew, T. L. & Spelsberg, T. C., Feb 1 2007, In : Journal of cellular biochemistry. 100, 2, p. 315-325 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

The common long-QT syndrome mutation KCNQ1/A341V causes unusually severe clinical manifestations in patients with different ethnic backgrounds: Toward a mutation-specific risk stratification

Crotti, L., Spazzolini, C., Schwartz, P. J., Shimizu, W., Denjoy, I., Schulze-Bahr, E., Zaklyazminskaya, E. V., Swan, H., Ackerman, M. J., Moss, A. J., Wilde, A. A. M., Horie, M., Brink, P. A., Insolia, R., De Ferrari, G. M. & Crimi, G., Nov 1 2007, In : Circulation. 116, 21, p. 2366-2375 10 p.

Research output: Contribution to journalArticle

112 Scopus citations

Usefulness of Brain Natriuretic Peptide Levels in the Clinical Evaluation of Patients With Hypertrophic Cardiomyopathy

Binder, J., Ommen, S. R., Chen, H. H., Ackerman, M. J., Tajik, A. J. & Jaffe, A. S., Aug 15 2007, In : American Journal of Cardiology. 100, 4, p. 712-714 3 p.

Research output: Contribution to journalArticle

19 Scopus citations

Ventricular ectopy during REM sleep: Implications for nocturnal sudden cardiac death

Garcia-Touchard, A., Somers, V. K., Kara, T., Nykodym, J., Shamsuzzaman, A., Lanfranchi, P. & Ackerman, M. J., May 1 2007, In : Nature Clinical Practice Cardiovascular Medicine. 4, 5, p. 284-288 5 p.

Research output: Contribution to journalArticle

17 Scopus citations
2008

alpha-1-syntrophin mutation and the long-QT syndrome: a disease of sodium channel disruption.

Wu, G., Ai, T., Kim, J. J., Mohapatra, B., Xi, Y., Li, Z., Abbasi, S., Purevjav, E., Samani, K., Ackerman, M. J., Qi, M., Moss, A. J., Shimizu, W., Towbin, J. A., Cheng, J. & Vatta, M., Aug 2008, In : Circulation. Arrhythmia and electrophysiology. 1, 3, p. 193-201 9 p.

Research output: Contribution to journalArticle

94 Scopus citations

A mutation in telethonin alters Nav1.5 function

Mazzone, A., Strege, P. R., Tester, D. J., Bernard, C. E., Faulkner, G., De Giorgio, R., Makielski, J. C., Stanghellini, V., Gibbons, S. J., Ackerman, M. J. & Farrugia, G., Jun 13 2008, In : Journal of Biological Chemistry. 283, 24, p. 16537-16544 8 p.

Research output: Contribution to journalArticle

49 Scopus citations

A mutation in telethonin alters Nav1.5 function (Journal of Biological Chemistry (2008) 283 (16537-16544))

Mazzone, A., Strege, P. R., Tester, D. J., Bernard, C. E., Faulkner, G., De Giorgio, R., Makielski, J. C., Stanghellini, V., Gibbons, S. J., Ackerman, M. J. & Farrugia, G., Aug 8 2008, In : Journal of Biological Chemistry. 283, 32, 1 p.

Research output: Contribution to journalComment/debate

Arrhythmogenic malignancies in hypertrophic cardiomyopathy

Menon, S. C., Bos, J. M., Ommen, S. R. & Ackerman, M. J., Dec 1 2008, Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. Springer London, p. 610-626 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

A splice site mutation in hERG leads to cryptic splicing in human long QT syndrome

Gong, Q., Zhang, L., Moss, A. J., Vincent, G. M., Ackerman, M. J., Robinson, J. C., Jones, M. A., Tester, D. J. & Zhou, Z., Mar 1 2008, In : Journal of Molecular and Cellular Cardiology. 44, 3, p. 502-509 8 p.

Research output: Contribution to journalArticle

18 Scopus citations

Congenital long QT syndrome

Ackerman, M. J., Khositseth, A., Tester, D. J. & Schwartz, P. J., Dec 1 2008, Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. Springer London, p. 462-482 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations

Depletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms

Chen, Z., Huang, W., Dahme, T., Rottbauer, W., Ackerman, M. J. & Xu, X., Jul 1 2008, In : Cardiovascular research. 79, 1, p. 97-108 12 p.

Research output: Contribution to journalArticle

55 Scopus citations

Electrical diseases of the heart: Genetics, mechanisms, treatment, prevention

Gussak, I., Antzelevitch, C., Wilde, A. A. M., Friedman, P. A., Ackerman, M. J. & Shen, W. K., Dec 1 2008, Springer London. 968 p.

Research output: Book/ReportBook

12 Scopus citations

Genetic testing

Tester, D. J. & Ackerman, M. J., Dec 1 2008, Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. Springer London, p. 444-458 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Impact of Septal Myectomy on Left Atrial Volume and Left Ventricular Diastolic Filling Patterns: An Echocardiographic Study of Young Patients with Obstructive Hypertrophic Cardiomyopathy

Menon, S. C., Ackerman, M. J., Ommen, S. R., Cabalka, A. K., Hagler, D. J., O'Leary, P. W., Dearani, J. A., Cetta, F. & Eidem, B. W., Jun 1 2008, In : Journal of the American Society of Echocardiography. 21, 6, p. 684-688 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Long-QT syndrome after age 40

Goldenberg, I., Moss, A. J., Peterson, D. R., McNitt, S., Zareba, W., Andrews, M. L., Robinson, J. L., Locati, E. H., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Napolitano, C., Priori, S. G., Qi, M., Schwartz, P. J., Towbin, J. A., Vincent, G. M. & Zhang, L., Apr 29 2008, In : Circulation. 117, 17, p. 2192-2201 10 p.

Research output: Contribution to journalArticle

112 Scopus citations

Mechanical Dysfunction in Extreme QT Prolongation

Vyas, H., O'Leary, P. W., Earing, M. G., Cetta, F. & Ackerman, M. J., May 2008, In : Journal of the American Society of Echocardiography. 21, 5, p. 511.e15-511.e17

Research output: Contribution to journalArticle

14 Scopus citations

Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C

Landstrom, A. P., Parvatiyar, M. S., Pinto, J. R., Marquardt, M. L., Bos, J. M., Tester, D. J., Ommen, S. R., Potter, J. D. & Ackerman, M. J., Aug 1 2008, In : Journal of Molecular and Cellular Cardiology. 45, 2, p. 281-288 8 p.

Research output: Contribution to journalArticle

75 Scopus citations

Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy

Olivotto, I., Girolami, F., Ackerman, M. J., Nistri, S., Bos, J. M., Zachara, E., Ommen, S. R., Theis, J. L., Vaubel, R. A., Re, F., Armentano, C., Poggesi, C., Torricelli, F. & Cecchi, F., Jun 2008, In : Mayo Clinic proceedings. 83, 6, p. 630-638 9 p.

Research output: Contribution to journalArticle

255 Scopus citations

Novel gene and mutation discovery in congenital long QT syndrome: Let's keep looking where the street lamp standeth

Tester, D. J. & Ackerman, M. J., Sep 1 2008, In : Heart rhythm. 5, 9, p. 1282-1284 3 p.

Research output: Contribution to journalEditorial

16 Scopus citations
47 Scopus citations

Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with long-QT syndrome

Sale, H., Wang, J., O'Hara, T. J., Tester, D. J., Phartiyal, P., He, J. Q., Rudy, Y., Ackerman, M. J. & Robertson, G. A., Sep 26 2008, In : Circulation research. 103, 7, p. e81-e95

Research output: Contribution to journalArticle

85 Scopus citations
70 Scopus citations

Prevalence, clinical significance, and natural history of left ventricular apical aneurysms in hypertrophic cardiomyopathy

Maron, M. S., Finley, J. J., Bos, J. M., Hauser, T. H., Manning, W. J., Haas, T. S., Lesser, J. R., Udelson, J. E., Ackerman, M. J. & Maron, B. J., Oct 7 2008, In : Circulation. 118, 15, p. 1541-1549 9 p.

Research output: Contribution to journalArticle

294 Scopus citations

Prevalence of early-onset atrial fibrillation in congenital long QT syndrome

Johnson, J. N., Tester, D. J., Perry, J., Salisbury, B. A., Reed, C. R. & Ackerman, M. J., May 1 2008, In : Heart rhythm. 5, 5, p. 704-709 6 p.

Research output: Contribution to journalArticle

113 Scopus citations

Provocative testing in inherited arrhythmias

Shimizu, W. & Ackerman, M. J., Dec 1 2008, Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. Springer London, p. 424-433 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Relationship between sex, shape, and substrate in hypertrophic cardiomyopathy

Bos, J. M., Theis, J. L., Tajik, A. J., Gersh, B. J., Ommen, S. R. & Ackerman, M. J., Jun 1 2008, In : American Heart Journal. 155, 6, p. 1128-1134 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital Long-QT syndrome

Goldenberg, I., Moss, A. J., Peterson, D. R., McNitt, S., Zareba, W., Andrews, M. L., Robinson, J. L., Locati, E. H., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Napolitano, C., Priori, S. G., Qi, M., Schwartz, P. J., Towbin, J. A., Vincent, G. M. & Zhang, L., Apr 29 2008, In : Circulation. 117, 17, p. 2184-2191 8 p.

Research output: Contribution to journalArticle

201 Scopus citations

Risk of death in the long QT syndrome when a sibling has died

Kaufman, E. S., McNitt, S., Moss, A. J., Zareba, W., Robinson, J. L., Hall, W. J., Ackerman, M. J., Benhorin, J., Locati, E. T., Napolitano, C., Priori, S. G., Schwartz, P. J., Towbin, J. A., Vincent, G. M. & Zhang, L., Jun 1 2008, In : Heart rhythm. 5, 6, p. 831-836 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Significance of Left Atrial Volume in Patients < 20 Years of Age With Hypertrophic Cardiomyopathy

Menon, S. C., Ackerman, M. J., Cetta, F., O'Leary, P. W. & Eidem, B. W., Nov 15 2008, In : American Journal of Cardiology. 102, 10, p. 1390-1393 4 p.

Research output: Contribution to journalArticle

28 Scopus citations

Sudden cardiac death in infancy: Focus on prolonged repolarization

Schwartz, P. J., Stramba-Badiale, M., Crotti, L. & Ackerman, M. J., Dec 1 2008, Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. Springer London, p. 924-933 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Sudden infant death syndrome: Genetic studies in cardiorespiratory and autonomic regulation

Weese-Mayer, D. E., Berry-Kravis, E. M., Ackerman, M. J. & Marazita, M. L., Jan 1 2008, Sleep and Breathing in Children: Developmental Changes in Breathing During Sleep, Second Edition. CRC Press, Vol. 224. p. 224-313 90 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sudden infant death syndrome: Study of genes pertinent to cardiorespiratory and autonomic regulation

Weese-Mayer, D. E., Ackerman, M. J., Marazita, M. L. & Berry-Kravis, E. M., Jan 1 2008, Genetic Basis for Respiratory Control Disorders. Springer US, p. 85-109 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Suppression of atrial fibrillation with mexiletine pharmacotherapy in a young woman with type 1 long QT syndrome

El Yaman, M., Perry, J., Makielski, J. C. & Ackerman, M. J., Mar 1 2008, In : Heart rhythm. 5, 3, p. 472-474 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex

Ueda, K., Valdivia, C., Medeiros-Domingo, A., Tester, D. J., Vatta, M., Farrugia, G., Ackerman, M. J. & Makielski, J. C., Jul 8 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 27, p. 9355-9360 6 p.

Research output: Contribution to journalArticle

248 Scopus citations

Systems approach to understanding electromechanical activity in the human heart a national heart, lung, and blood institute workshop summary

Rudy, Y., Ackerman, M. J., Bers, D. M., Clancy, C. E., Houser, S. R., London, B., McCulloch, A. D., Przywara, D. A., Rasmusson, R. L., Solaro, J. R., Trayanova, N. A., Van Wagoner, D. R., Varro, A., Weiss, J. N. & Lathrop, D. A., Sep 9 2008, In : Circulation. 118, 11, p. 1202-1211 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Unmasking concealed long QT syndrome

Ackerman, M. J., Jan 1 2008, In : Heart rhythm. 5, 1, p. 8-10 3 p.

Research output: Contribution to journalEditorial

8 Scopus citations

Ventricular ectopy during treadmill exercise stress testing in the evaluation of long QT syndrome

Horner, J. M. & Ackerman, M. J., Dec 1 2008, In : Heart rhythm. 5, 12, p. 1690-1694 5 p.

Research output: Contribution to journalArticle

24 Scopus citations
2009

A functional and structural study of tropon in C mutations related to hypertrophic cardiomyopathy

Pinto, J. R., Parvatiyar, M. S., Jones, M. A., Liang, J., Ackerman, M. J. & Potter, J. D., Jul 10 2009, In : Journal of Biological Chemistry. 284, 28, p. 19090-19100 11 p.

Research output: Contribution to journalArticle

49 Scopus citations

Cardiac Ankyrin Repeat Protein Gene (ANKRD1) Mutations in Hypertrophic Cardiomyopathy

Arimura, T., Bos, J. M., Sato, A., Kubo, T., Okamoto, H., Nishi, H., Harada, H., Koga, Y., Moulik, M., Doi, Y. L., Towbin, J. A., Ackerman, M. J. & Kimura, A., Jul 21 2009, In : Journal of the American College of Cardiology. 54, 4, p. 334-342 9 p.

Research output: Contribution to journalArticle

105 Scopus citations

Cardiomyopathic and channelopathic causes of sudden unexplained death in infants and children

Tester, D. J. & Ackerman, M. J., Jul 24 2009, In : Annual Review of Medicine. 60, p. 69-84 16 p.

Research output: Contribution to journalReview article

87 Scopus citations

Clinical Implications for Patients With Long QT Syndrome Who Experience a Cardiac Event During Infancy

Spazzolini, C., Mullally, J., Moss, A. J., Schwartz, P. J., McNitt, S., Ouellet, G., Fugate, T., Goldenberg, I., Jons, C., Zareba, W., Robinson, J. L., Ackerman, M. J., Benhorin, J., Crotti, L., Kaufman, E. S., Locati, E. H., Qi, M., Napolitano, C., Priori, S. G., Towbin, J. A. & 1 others, Vincent, G. M., Aug 25 2009, In : Journal of the American College of Cardiology. 54, 9, p. 832-837 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Device complications and inappropriate implantable cardioverter defibrillator shocks in patients with hypertrophic cardiomyopathy

Lin, G., Nishimura, R. A., Gersh, B. J., Phil, D., Ommen, S. R., Ackerman, M. J. & Brady, P. A., May 1 2009, In : Heart. 95, 9, p. 709-714 6 p.

Research output: Contribution to journalArticle

99 Scopus citations

Diagnostic, Prognostic, and Therapeutic Implications of Genetic Testing for Hypertrophic Cardiomyopathy

Bos, J. M., Towbin, J. A. & Ackerman, M. J., Jul 14 2009, In : Journal of the American College of Cardiology. 54, 3, p. 201-211 11 p.

Research output: Contribution to journalReview article

241 Scopus citations

Diastolic Dysfunction and Its Histopathological Correlation in Obstructive Hypertrophic Cardiomyopathy in Children and Adolescents

Menon, S. C., Eidem, B. W., Dearani, J. A., Ommen, S. R., Ackerman, M. J. & Miller, D., Dec 2009, In : Journal of the American Society of Echocardiography. 22, 12, p. 1327-1334 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

Expression patterns of cardiac myofilament proteins

Theis, J. L., Bos, J. M., Theis, J. D., Miller, D. V., Dearani, J. A., Schaff, H. V., Gersh, B. J., Ommen, S. R., Moss, R. L. & Ackerman, M. J., Jul 1 2009, In : Circulation: Heart Failure. 2, 4, p. 325-333 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Genetic testing for long-qt syndrome: Distinguishing pathogenic mutations from benign variants

Kapa, S., Tester, D. J., Salisbury, B. A., Harris-Kerr, C., Pungliya, M. S., Alders, M., Wilde, A. A. M. & Ackerman, M. J., Nov 1 2009, In : Circulation. 120, 18, p. 1752-1760 9 p.

Research output: Contribution to journalArticle

242 Scopus citations

Genotype-Phenotype Aspects of Type 2 Long QT Syndrome

Shimizu, W., Moss, A. J., Wilde, A. A. M., Towbin, J. A., Ackerman, M. J., January, C. T., Tester, D. J., Zareba, W., Robinson, J. L., Qi, M., Vincent, G. M., Kaufman, E. S., Hofman, N., Noda, T., Kamakura, S., Miyamoto, Y., Shah, S., Amin, V., Goldenberg, I., Andrews, M. L. & 1 others, McNitt, S., Nov 24 2009, In : Journal of the American College of Cardiology. 54, 22, p. 2052-2062 11 p.

Research output: Contribution to journalArticle

168 Scopus citations

GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A

Valdivia, C. R., Ueda, K., Ackerman, M. J. & Makielski, J. C., Oct 1 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 4, p. H1446-H1452

Research output: Contribution to journalArticle

74 Scopus citations

GWAS or Gee Whiz, PSAS or Pshaw: Elucidating the biologic and clinical significance of genetic variation in cardiovascular disease

Landstrom, A. P. & Ackerman, M. J., Dec 1 2009, In : Heart rhythm. 6, 12, p. 1751-1753 3 p.

Research output: Contribution to journalEditorial

5 Scopus citations