Michael John Ackerman, MD, PhD, FACC

  • 38100 Citations
  • 108 Scopus h-Index
1991 …2020

Research output per year

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Research Output

Article

Treatment and prevention modalities

Powell, B. D., Shen, W. K., Ackerman, M. J. & Gussak, I., Jan 1 2013, In : Unknown Journal. p. 494-496 3 p.

Research output: Contribution to journalArticle

Triadin Knockout Syndrome Is Absent in a Multi-Center Molecular Autopsy Cohort of Sudden Infant Death Syndrome and Sudden Unexplained Death in the Young and Is Extremely Rare in the General Population

Clemens, D. J., Gray, B., Bagnall, R. D., Tester, D. J., Dotzler, S. M., Giudicessi, J. R., Matthews, E., Semsarian, C., Behr, E. R. & Ackerman, M. J., 2020, (Accepted/In press) In : Circulation: Genomic and Precision Medicine. p. 52-58 7 p., 002731.

Research output: Contribution to journalArticle

Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndrome

Goldenberg, I., Thottathil, P., Lopes, C. M., Moss, A. J., McNitt, S., Jin, O. U., Robinson, J. L., Zareba, W., Ackerman, M. J., Kaufman, E. S., Towbin, J. A., Vincent, M. & Barsheshet, A., Jan 2012, In : Heart rhythm. 9, 1, p. 49-56 8 p.

Research output: Contribution to journalArticle

30 Scopus citations

Trigger-specific risk factors and response to therapy in long QT syndrome type 2

Kim, J. A., Lopes, C. M., Moss, A. J., McNitt, S., Barsheshet, A., Robinson, J. L., Zareba, W., Ackerman, M. J., Kaufman, E. S., Towbin, J. A., Vincent, M. & Goldenberg, I., Dec 2010, In : Heart rhythm. 7, 12, p. 1797-1805 9 p.

Research output: Contribution to journalArticle

47 Scopus citations

Truncations of titin causing dilated cardiomyopathy

Herman, D. S., Lam, L., Taylor, M. R. G., Wang, L., Teekakirikul, P., Christodoulou, D., Conner, L., DePalma, S. R., McDonough, B., Sparks, E., Teodorescu, D. L., Cirino, A. L., Banner, N. R., Pennell, D. J., Graw, S., Merlo, M., Di Lenarda, A., Sinagra, G., Bos, J. M., Ackerman, M. J. & 9 others, Mitchell, R. N., Murry, C. E., Lakdawala, N. K., Ho, C. Y., Barton, P. J. R., Cook, S. A., Mestroni, L., Seidman, J. G. & Seidman, C. E., Feb 16 2012, In : New England Journal of Medicine. 366, 7, p. 619-628 10 p.

Research output: Contribution to journalArticle

641 Scopus citations

Two novel cardiac atrial K+ channels, IK.AA and IK.PC

Wallert, M. A., Ackerman, M. J., Kim, D. & Clapham, D. E., Nov 1 1991, In : Journal of General Physiology. 98, 5, p. 921-939 19 p.

Research output: Contribution to journalArticle

Open Access
25 Scopus citations

Two-stage Study of Familial Prostate Cancer by Whole-exome Sequencing and Custom Capture Identifies 10 Novel Genes Associated with the Risk of Prostate Cancer

Schaid, D. J., McDonnell, S. K., FitzGerald, L. M., DeRycke, L., Fogarty, Z., Giles, G. G., MacInnis, R. J., Southey, M. C., Nguyen-Dumont, T., Cancel-Tassin, G., Cussenot, O., Whittemore, A. S., Sieh, W., Ioannidis, N. M., Hsieh, C. L., Stanford, J. L., Schleutker, J., Cropp, C. D., Carpten, J., Hoegel, J. & 19 others, Eeles, R., Kote-Jarai, Z., Ackerman, M. J., Klein, C. J., Mandal, D., Cooney, K. A., Bailey-Wilson, J. E., Helfand, B., Catalona, W. J., Wiklund, F., Riska, S., Bahetti, S., Larson, M. C., Cannon Albright, L., Teerlink, C., Xu, J., Isaacs, W., Ostrander, E. A. & Thibodeau, S. N., 2020, (Accepted/In press) In : European urology.

Research output: Contribution to journalArticle

Type 8 long QT syndrome: Pathogenic variants in CACNA1C-encoded Cav1.2 cluster in STAC protein binding site

Mellor, G. J., Panwar, P., Lee, A. K., Steinberg, C., Hathaway, J. A., Bartels, K., Christian, S., Balaji, S., Roberts, J. D., Simpson, C. S., Boczek, N. J., Tester, D. J., Radbill, A. E., Mok, N. S., Hamilton, R. M., Kaufman, E. S., Eugenio, P. L., Weiss, R., January, C., McDaniel, G. M. & 10 others, Leather, R. A., Erickson, C., Falik, S., Behr, E. R., Wilde, A. A. M., Sanatani, S., Ackerman, M. J., Van Petegem, F., Krahn, A. D. & Laksman, Z., Nov 1 2019, In : Europace. 21, 11, p. 1725-1732 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Unexplained drownings and the cardiac channelopathies: A molecular autopsy series

Tester, D. J., Medeiros-Domingo, A., Will, M. L. & Ackerman, M. J., Oct 2011, In : Mayo Clinic proceedings. 86, 10, p. 941-947 7 p.

Research output: Contribution to journalArticle

56 Scopus citations

Unique mixed phenotype and unexpected functional effect revealed by novel compound heterozygosity mutations involving SCN5A

Medeiros-Domingo, A., Tan, B. H., Iturralde-Torres, P., Tester, D. J., Tusié-Luna, T., Makielski, J. C. & Ackerman, M. J., Aug 2009, In : Heart rhythm. 6, 8, p. 1170-1175 6 p.

Research output: Contribution to journalArticle

13 Scopus citations
Open Access
98 Scopus citations

Usefulness of Brain Natriuretic Peptide Levels in the Clinical Evaluation of Patients With Hypertrophic Cardiomyopathy

Binder, J., Ommen, S. R., Chen, H. H., Ackerman, M. J., Tajik, A. J. & Jaffe, A. S., Aug 15 2007, In : American Journal of Cardiology. 100, 4, p. 712-714 3 p.

Research output: Contribution to journalArticle

21 Scopus citations

Use of Echocardiography in Patients with Hypertrophic Cardiomyopathy: Clinical Implications of Massive Hypertrophy

Sorajja, P., Nishimura, R. A., Ommen, S. R., Ackerman, M. J., Tajik, A. J. & Gersh, B. J., Jun 1 2006, In : Journal of the American Society of Echocardiography. 19, 6, p. 788-795 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

Using the genome aggregation database, computational pathogenicity prediction tools, and patch clamp heterologous expression studies to demote previously published long QT syndrome type 1 mutations from pathogenic to benign

Clemens, D. J., Lentino, A. R., Kapplinger, J. D., Ye, D., Zhou, W., Tester, D. J. & Ackerman, M. J., Apr 2018, In : Heart rhythm. 15, 4, p. 555-561 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Utility of T-wave amplitude as a non-invasive risk marker of sudden cardiac death in hypertrophic cardiomyopathy

Sugrue, A., Killu, A. M., Desimone, C. V., Chahal, A. A., Vogt, J. C., Kremen, V., Hai, J., Hodge, D. O., Acker, N. G., Geske, J. B., Ackerman, M. J., Ommen, S. R., Lin, G., Noseworthy, P. A. & Brady, P. A., Feb 1 2017, In : Open Heart. 4, 1, e000561.

Research output: Contribution to journalArticle

6 Scopus citations

Utilization of the genome aggregation database, in silico tools, and heterologous expression patch-clamp studies to identify and demote previously published type 2 long QT syndrome: Causative variants from pathogenic to likely benign

Mattivi, C. L., Ye, D., Tester, D. J., Clemens, D. J., Zhou, W., Giudicessi, J. R. & Ackerman, M. J., Jan 1 2019, (Accepted/In press) In : Heart rhythm.

Research output: Contribution to journalArticle

1 Scopus citations

Validation and Disease Risk Assessment of Previously Reported Genome-Wide Genetic Variants Associated With Brugada Syndrome: SADS-TW BrS Registry

Jimmy Juang, J. M., Liu, Y. B., Julius Chen, C. Y., Yu, Q. Y., Chattopadhyay, A., Lin, L. Y., Chen, W. J., Yu, C. C., Huang, H. C., Ho, L. T., Lai, L. P., Hwang, J. J., Lin, T. T., Liao, M. T., Chen, J. J., Sherri Yeh, S. F., Chuang, J. Y., Yang, D. H., Lin, J. L., Lu, T. P. & 2 others, Chuang, E. Y. & Ackerman, M. J., Aug 1 2020, In : Circulation. Genomic and precision medicine. 13, 4, p. e002797

Research output: Contribution to journalArticle

Open Access

Variants in the 3′ untranslated region of the KCNQ1-encoded K v7.1 potassium channel modify disease severity in patients with type 1 long QT syndrome in an allele-specific manner

Amin, A. S., Giudicessi, J. R., Tijsen, A. J., Spanjaart, A. M., Reckman, Y. J., Klemens, C. A., Tanck, M. W., Kapplinger, J. D., Hofman, N., Sinner, M. F., Mller, M., Wijnen, W. J., Tan, H. L., Bezzina, C. R., Creemers, E. E., Wilde, A. A. M., Ackerman, M. J. & Pinto, Y. M., Mar 2012, In : European heart journal. 33, 6, p. 714-723 10 p.

Research output: Contribution to journalArticle

100 Scopus citations

Vectorcardiography identifies patients with electrocardiographically concealed long QT syndrome

Cortez, D., Bos, J. M. & Ackerman, M. J., Jun 1 2017, In : Heart Rhythm. 14, 6, p. 894-899 6 p.

Research output: Contribution to journalArticle

7 Scopus citations

Ventricular ectopy during REM sleep: Implications for nocturnal sudden cardiac death

Garcia-Touchard, A., Somers, V. K., Kara, T., Nykodym, J., Shamsuzzaman, A., Lanfranchi, P. & Ackerman, M. J., May 2007, In : Nature Clinical Practice Cardiovascular Medicine. 4, 5, p. 284-288 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Ventricular ectopy during treadmill exercise stress testing in the evaluation of long QT syndrome

Horner, J. M. & Ackerman, M. J., Dec 2008, In : Heart rhythm. 5, 12, p. 1690-1694 5 p.

Research output: Contribution to journalArticle

24 Scopus citations

Ventricular fibrillation after elective surgery in an adolescent with long QT syndrome

Kim, S. J., Pundi, K. N., Bos, J. M. & Ackerman, M. J., Nov 26 2015, In : BMJ case reports. 2015, A1719.

Research output: Contribution to journalArticle

1 Scopus citations

Ventricular premature contraction associated with mitral valve prolapse

Hong-TaoYuan, Yang, M., Zhong, L., Lee, Y. H., Vaidya, V. R., Asirvatham, S. J., Ackerman, M. J., Pislaru, S. V., Suri, R. M., Slusser, J. P., Hodge, D. O., Wang, Y. T. & Cha, Y-M., Oct 15 2016, In : International Journal of Cardiology. 221, p. 1144-1149 6 p.

Research output: Contribution to journalArticle

10 Scopus citations

Wearable cardioverter defibrillators for patients with long QT syndrome

Owen, H. J., Bos, J. M. & Ackerman, M. J., Jan 1 2018, (Accepted/In press) In : International Journal of Cardiology.

Research output: Contribution to journalArticle

6 Scopus citations

When i go in to wake them ... i wonder: Parental perceptions about congenital long QT syndrome

Farnsworth, M. M., Fosyth, D., Haglund, C. & Ackerman, M. J., Jun 1 2006, In : Journal of the American Academy of Nurse Practitioners. 18, 6, p. 284-290 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Whole-exome molecular autopsy after exertion-related sudden unexplained death in the young

Anderson, J. H., Tester, D. J., Will, M. L. & Ackerman, M. J., Jun 1 2016, In : Circulation: Cardiovascular Genetics. 9, 3, p. 259-265 7 p.

Research output: Contribution to journalArticle

41 Scopus citations

Whole Exome Sequencing, Familial Genomic Triangulation, and Systems Biology Converge to Identify a Novel Nonsense Mutation in TAB2-encoded TGF-beta Activated Kinase 1 in a Child with Polyvalvular Syndrome

Ackerman, J. P., Smestad, J. A., Tester, D. J., Qureshi, M. Y., Crabb, B. A., Mendelsohn, N. J. & Ackerman, M. J., Sep 1 2016, In : Congenital Heart Disease. 11, 5, p. 452-461 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
12 Scopus citations

Whole exome sequencing with genomic triangulation implicates CDH2-encoded N-cadherin as a novel pathogenic substrate for arrhythmogenic cardiomyopathy

Turkowski, K. L., Tester, D. J., Bos, J. M., Haugaa, K. H. & Ackerman, M. J., Mar 1 2017, In : Congenital Heart Disease. 12, 2, p. 226-235 10 p.

Research output: Contribution to journalArticle

18 Scopus citations

Whole genome sequencing identifies etiology of recurrent male intrauterine fetal death

Shehab, O., Tester, D. J., Ackerman, N. C., Cowchock, F. S. & Ackerman, M. J., Oct 1 2017, In : Prenatal Diagnosis. 37, 10, p. 1040-1045 6 p.

Research output: Contribution to journalArticle

8 Scopus citations

Women with hypertrophic cardiomyopathy have worse survival

Geske, J. B., Ong, K. C., Siontis, K. C., Hebl, V. B., Ackerman, M. J., Hodge, D. O., Miller, V. M., Nishimura, R. A., Oh, J. K., Schaff, H. V., Gersh, B. J. & Ommen, S. R., 2017, In : European heart journal. 38, 46, p. 3434-3440 7 p.

Research output: Contribution to journalArticle

51 Scopus citations

Yield of genetic testing in hypertrophic cardiomyopathy

Van Driest, S. L., Ommen, S. R., Tajik, A. J., Gersh, B. J. & Ackerman, M. J., Jun 2005, In : Mayo Clinic proceedings. 80, 6, p. 739-744 6 p.

Research output: Contribution to journalArticle

127 Scopus citations

Yield of the RYR2 Genetic Test in Suspected Catecholaminergic Polymorphic Ventricular Tachycardia and Implications for Test Interpretation

Kapplinger, J. D., Pundi, K. N., Larson, N. B., Callis, T. E., Tester, D. J., Bikker, H., Wilde, A. A. M. & Ackerman, M. J., Feb 1 2018, In : Circulation. Genomic and precision medicine. 11, 2, p. e001424

Research output: Contribution to journalArticle

11 Scopus citations

α1-Syntrophin mutations identified in sudden infant death syndrome cause an increase in late cardiac sodium current

Ackerman, M. J., Cheng, J., Van Norstrand, D. W., Medeiros-Domingo, A., Valdivia, C., Tan, B. H., Ye, B., Kroboth, S., Vatta, M., Tester, D. J., January, C. T. & Makielski, J. C., Dec 2009, In : Circulation: Arrhythmia and Electrophysiology. 2, 6, p. 667-676 10 p.

Research output: Contribution to journalArticle

64 Scopus citations

β-blocker therapy failures in symptomatic probands with genotyped long-QT syndrome

Chatrath, R., Bell, C. M. & Ackerman, M. J., Sep 1 2004, In : Pediatric Cardiology. 25, 5, p. 459-465 7 p.

Research output: Contribution to journalArticle

57 Scopus citations