Michael John Ackerman, MD, PhD, FACC

  • 38396 Citations
  • 108 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2007

Long QT Syndrome in Adults

Sauer, A. J., Moss, A. J., McNitt, S., Peterson, D. R., Zareba, W., Robinson, J. L., Qi, M., Goldenberg, I., Hobbs, J. B., Ackerman, M. J., Benhorin, J., Hall, W. J., Kaufman, E. S., Locati, E. H., Napolitano, C., Priori, S. G., Schwartz, P. J., Towbin, J. A., Vincent, G. M. & Zhang, L., Jan 23 2007, In : Journal of the American College of Cardiology. 49, 3, p. 329-337 9 p.

Research output: Contribution to journalArticle

284 Scopus citations

Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L) mutations in sudden infant death syndrome

Van Norstrand, D. W., Valdivia, C. R., Tester, D. J., Ueda, K., London, B., Makielski, J. C. & Ackerman, M. J., Nov 2007, In : Circulation. 116, 20, p. 2253-2259 7 p.

Research output: Contribution to journalArticle

140 Scopus citations

Mutation in glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias

London, B., Michalec, M., Mehdi, H., Zhu, X., Kerchner, L., Sanyal, S., Viswanathan, P. C., Pfahnl, A. E., Shang, L. L., Madhusudanan, M., Baty, C. J., Lagana, S., Aleong, R., Gutmann, R., Ackerman, M. J., McNamara, D. M., Weiss, R. & Dudley, S. C., Nov 2007, In : Circulation. 116, 20, p. 2260-2268 9 p.

Research output: Contribution to journalArticle

344 Scopus citations

Mutation of an A-kinase-anchoring protein causes long-QT syndrome

Chen, L., Marquardt, M. L., Tester, D. J., Sampson, K. J., Ackerman, M. J. & Kass, R. S., Dec 26 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 52, p. 20990-20995 6 p.

Research output: Contribution to journalArticle

240 Scopus citations

Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans

Landstrom, A. P., Weisleder, N., Batalden, K. B., Martijn Bos, J., Tester, D. J., Ommen, S. R., Wehrens, X. H. T., Claycomb, W. C., Ko, J. K., Hwang, M., Pan, Z., Ma, J. & Ackerman, M. J., Jun 2007, In : Journal of Molecular and Cellular Cardiology. 42, 6, p. 1026-1035 10 p.

Research output: Contribution to journalArticle

118 Scopus citations

Novel mechanism for sudden infant death syndrome: Persistent late sodium current secondary to mutations in caveolin-3

Cronk, L. B., Ye, B., Kaku, T., Tester, D. J., Vatta, M., Makielski, J. C. & Ackerman, M. J., Feb 2007, In : Heart rhythm. 4, 2, p. 161-166 6 p.

Research output: Contribution to journalArticle

180 Scopus citations

Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms

McKellar, S. H., Tester, D. J., Yagubyan, M., Majumdar, R., Ackerman, M. J. & Sundt, T. M., Aug 1 2007, In : Journal of Thoracic and Cardiovascular Surgery. 134, 2, p. 290-296 7 p.

Research output: Contribution to journalArticle

173 Scopus citations

Postmortem Long QT Syndrome Genetic Testing for Sudden Unexplained Death in the Young

Tester, D. J. & Ackerman, M. J., Jan 16 2007, In : Journal of the American College of Cardiology. 49, 2, p. 240-246 7 p.

Research output: Contribution to journalArticle

287 Scopus citations

Recommendations and considerations related to preparticipation screening for cardiovascular abnormalities in competitive athletes: 2007 Update: A scientific statement from the American Heart Association council on nutrition, physical activity, and metabolism: Endorsed by the American College of Cardiology foundation

Maron, B. J., Thompson, P. D., Ackerman, M. J., Balady, G., Berger, S., Cohen, D., Dimeff, R., Douglas, P. S., Glover, D. W., Hutter, A. M., Krauss, M. D., Maron, M. S., Mitten, M. J., Roberts, W. O. & Puffer, J. C., Mar 2007, In : Circulation. 115, 12, p. 1643-1655 13 p.

Research output: Contribution to journalReview article

751 Scopus citations

SCN4B-encoded sodium channel β4 subunit in congenital long-QT syndrome

Medeiros-Domingo, A., Kaku, T., Tester, D. J., Iturralde-Torres, P., Itty, A., Ye, B., Valdivia, C., Ueda, K., Canizales-Quinteros, S., Tusié-Luna, M. T., Makielski, J. C. & Ackerman, M. J., Jul 2007, In : Circulation. 116, 2, p. 134-142 9 p.

Research output: Contribution to journalArticle

261 Scopus citations

Sudden Infant Death Syndrome: Review of implicated genetic factors

Weese-Mayer, D. E., Ackerman, M. J., Marazita, M. L. & Berry-Kravis, E. M., Apr 15 2007, In : American Journal of Medical Genetics, Part A. 143, 8, p. 771-788 18 p.

Research output: Contribution to journalReview article

103 Scopus citations

Surgical septal myectomy decreases the risk for appropriate implantable cardioverter defibrillator discharge in obstructive hypertrophic cardiomyopathy

McLeod, C. J., Ommen, S. R., Ackerman, M. J., Weivoda, P. L., Shen, W. K., Dearani, J. A., Schaff, H. V., Tajik, A. J. & Gersh, B. J., Nov 2007, In : European heart journal. 28, 21, p. 2583-2588 6 p.

Research output: Contribution to journalArticle

117 Scopus citations

TGFβ inducible early gene-1 (TIEG1) and cardiac hypertrophy: Discovery and characterization of a novel signaling pathway

Rajamannan, N. M., Subramaniam, M., Abraham, T. P., Vasile, V. C., Ackerman, M. J., Monroe, D. G., Chew, T. L. & Spelsberg, T. C., Feb 1 2007, In : Journal of cellular biochemistry. 100, 2, p. 315-325 11 p.

Research output: Contribution to journalArticle

42 Scopus citations

The common long-QT syndrome mutation KCNQ1/A341V causes unusually severe clinical manifestations in patients with different ethnic backgrounds: Toward a mutation-specific risk stratification

Crotti, L., Spazzolini, C., Schwartz, P. J., Shimizu, W., Denjoy, I., Schulze-Bahr, E., Zaklyazminskaya, E. V., Swan, H., Ackerman, M. J., Moss, A. J., Wilde, A. A. M., Horie, M., Brink, P. A., Insolia, R., De Ferrari, G. M. & Crimi, G., Nov 2007, In : Circulation. 116, 21, p. 2366-2375 10 p.

Research output: Contribution to journalArticle

115 Scopus citations

Usefulness of Brain Natriuretic Peptide Levels in the Clinical Evaluation of Patients With Hypertrophic Cardiomyopathy

Binder, J., Ommen, S. R., Chen, H. H., Ackerman, M. J., Tajik, A. J. & Jaffe, A. S., Aug 15 2007, In : American Journal of Cardiology. 100, 4, p. 712-714 3 p.

Research output: Contribution to journalArticle

21 Scopus citations

Ventricular ectopy during REM sleep: Implications for nocturnal sudden cardiac death

Garcia-Touchard, A., Somers, V. K., Kara, T., Nykodym, J., Shamsuzzaman, A., Lanfranchi, P. & Ackerman, M. J., May 2007, In : Nature Clinical Practice Cardiovascular Medicine. 4, 5, p. 284-288 5 p.

Research output: Contribution to journalArticle

17 Scopus citations
2006

Acquired long QT syndrome secondary to cesium chloride supplement

Vyas, H., Johnson, K., Houlihan, R., Bauer, B. A. & Ackerman, M. J., Dec 1 2006, In : Journal of Alternative and Complementary Medicine. 12, 10, p. 1011-1014 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Allelic dropout in long QT syndrome genetic testing: A possible mechanism underlying false-negative results

Tester, D. J., Cronk, L. B., Carr, J. L., Schulz, V., Salisbury, B. A., Judson, R. S. & Ackerman, M. J., Jul 1 2006, In : Heart rhythm. 3, 7, p. 815-821 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

A missense mutation in a ubiquitously expressed protein, vinculin, confers susceptibility to hypertrophic cardiomyopathy

Vasile, V. C., Ommen, S. R., Edwards, W. D. & Ackerman, M. J., Jul 7 2006, In : Biochemical and Biophysical Research Communications. 345, 3, p. 998-1003 6 p.

Research output: Contribution to journalArticle

67 Scopus citations

Clinical course and risk stratification of patients affected with the Jervell and Lange-Nielsen syndrome

Goldenberg, I., Moss, A. J., Zareba, W., Mcnitt, S., Robinson, J. L., Qi, M., Towbin, J. A., Ackerman, M. J. & Murphy, L., Nov 2006, In : Journal of cardiovascular electrophysiology. 17, 11, p. 1161-1168 8 p.

Research output: Contribution to journalArticle

69 Scopus citations

Echocardiographic-determined septal morphology in Z-disc hypertrophic cardiomyopathy

Theis, J. L., Martijn Bos, J., Bartleson, V. B., Will, M. L., Binder, J., Vatta, M., Towbin, J. A., Gersh, B. J., Ommen, S. R. & Ackerman, M. J., Dec 29 2006, In : Biochemical and Biophysical Research Communications. 351, 4, p. 896-902 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Echocardiography-guided genetic testing in hypertrophic cardiomyopathy: Septal morphological features predict the presence of myofilament mutations

Binder, J., Ommen, S. R., Gersh, B. J., Van Driest, S. L., Tajik, A. J., Nishimura, R. A. & Ackerman, M. J., Apr 2006, In : Mayo Clinic proceedings. 81, 4, p. 459-467 9 p.

Research output: Contribution to journalArticle

152 Scopus citations

Effect of Clinical Phenotype on Yield of Long QT Syndrome Genetic Testing

Tester, D. J., Will, M. L., Haglund, C. M. & Ackerman, M. J., Feb 21 2006, In : Journal of the American College of Cardiology. 47, 4, p. 764-768 5 p.

Research output: Contribution to journalArticle

142 Scopus citations

Epinephrine QT stress testing in congenital long QT syndrome

Vyas, H. & Ackerman, M. J., Oct 1 2006, In : Journal of Electrocardiology. 39, 4 SUPPL., p. S107-S113

Research output: Contribution to journalReview article

34 Scopus citations

Epinephrine QT stress testing in the evaluation of congenital long-QT syndrome: Diagnostic accuracy of the paradoxical QT response

Vyas, H., Hejlik, J. & Ackerman, M. J., Mar 1 2006, In : Circulation. 113, 11, p. 1385-1392 8 p.

Research output: Contribution to journalArticle

182 Scopus citations

Gastrointestinal symptoms in families of patients with an SCN5A-encoded cardiac channelopathy: Evidence of an intestinal channelopathy

Locke, G. R., Ackerman, M. J., Zinsmeister, A. R., Thapa, P. & Farrugia, G., Jun 2006, In : American Journal of Gastroenterology. 101, 6, p. 1299-1304 6 p.

Research output: Contribution to journalArticle

59 Scopus citations

Genotype-phenotype relationships involving hypertrophic cardiomyopathy-associated mutations in titin, muscle LIM protein, and telethonin

Bos, J. M., Poley, R. N., Ny, M., Tester, D. J., Xu, X., Vatta, M., Towbin, J. A., Gersh, B. J., Ommen, S. R. & Ackerman, M. J., May 2006, In : Molecular genetics and metabolism. 88, 1, p. 78-85 8 p.

Research output: Contribution to journalArticle

141 Scopus citations

Genotypic heterogeneity and phenotypic mimicry among unrelated patients referred for catecholaminergic polymorphic ventricular tachycardia genetic testing

Tester, D. J., Arya, P., Will, M., Haglund, C. M., Farley, A. L., Makielski, J. C. & Ackerman, M. J., Jul 2006, In : Heart rhythm. 3, 7, p. 800-805 6 p.

Research output: Contribution to journalArticle

100 Scopus citations

Identification of a metavinculin missense mutation, R975W, associated with both hypertrophic and dilated cardiomyopathy

Vasile, V. C., Will, M. L., Ommen, S. R., Edwards, W. D., Olson, T. M. & Ackerman, M. J., Feb 1 2006, In : Molecular genetics and metabolism. 87, 2, p. 169-174 6 p.

Research output: Contribution to journalArticle

76 Scopus citations

Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism

Anderson, C. L., Delisle, B. P., Anson, B. D., Kilby, J. A., Will, M. L., Tester, D. J., Gong, Q., Zhou, Z., Ackerman, M. J. & January, C. T., Jan 2006, In : Circulation. 113, 3, p. 365-373 9 p.

Research output: Contribution to journalArticle

299 Scopus citations

Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome

Vatta, M., Ackerman, M. J., Ye, B., Makielski, J. C., Ughanze, E. E., Taylor, E. W., Tester, D. J., Balijepalli, R. C., Foell, J. D., Li, Z., Kamp, T. J. & Towbin, J. A., Nov 2006, In : Circulation. 114, 20, p. 2104-2112 9 p.

Research output: Contribution to journalArticle

388 Scopus citations

Mutation detection in congenital long QT syndrome: cardiac channel gene screen using PCR, dHPLC, and direct DNA sequencing.

Tester, D. J., Will, M. L. & Ackerman, M. J., 2006, In : Methods in molecular medicine. 128, p. 181-207 27 p.

Research output: Contribution to journalArticle

24 Scopus citations

Obstructive hypertrophic cardiomyopathy is associated with reduced expression of vinculin in the intercalated disc

Vasile, V. C., Edwards, W. D., Ommen, S. R. & Ackerman, M. J., Oct 20 2006, In : Biochemical and Biophysical Research Communications. 349, 2, p. 709-715 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Pharmacogenetic issues in thorough QT trials

Judson, R. S., Salisbury, B. A., Reed, C. R. & Ackerman, M. J., Jan 1 2006, In : Molecular Diagnosis and Therapy. 10, 3, p. 153-162 10 p.

Research output: Contribution to journalReview article

10 Scopus citations

Promoting arrhythmia susceptibility

Bunch, T. J. & Ackerman, M. J., Jan 2006, In : Circulation. 113, 3, p. 330-332 3 p.

Research output: Contribution to journalEditorial

4 Scopus citations

Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndrome

Hobbs, J. B., Peterson, D. R., Moss, A. J., McNitt, S., Zareba, W., Goldenberg, I., Qi, M., Robinson, J. L., Sauer, A. J., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Locati, E. H., Napolitano, C., Priori, S. G., Towbin, J. A., Vincent, G. M. & Zhang, L., Sep 13 2006, In : Journal of the American Medical Association. 296, 10, p. 1249-1254 6 p.

Research output: Contribution to journalArticle

222 Scopus citations

The role of molecular autopsy in unexplained sudden cardiac death

Tester, D. J. & Ackerman, M. J., May 1 2006, In : Current opinion in cardiology. 21, 3, p. 166-172 7 p.

Research output: Contribution to journalReview article

177 Scopus citations

Use of Echocardiography in Patients with Hypertrophic Cardiomyopathy: Clinical Implications of Massive Hypertrophy

Sorajja, P., Nishimura, R. A., Ommen, S. R., Ackerman, M. J., Tajik, A. J. & Gersh, B. J., Jun 1 2006, In : Journal of the American Society of Echocardiography. 19, 6, p. 788-795 8 p.

Research output: Contribution to journalArticle

57 Scopus citations

When i go in to wake them ... i wonder: Parental perceptions about congenital long QT syndrome

Farnsworth, M. M., Fosyth, D., Haglund, C. & Ackerman, M. J., Jun 1 2006, In : Journal of the American Academy of Nurse Practitioners. 18, 6, p. 284-290 7 p.

Research output: Contribution to journalArticle

25 Scopus citations
2005

Acquired QT prolongation associated with esophagitis and acute weight loss: How to evaluate a prolonged QT interval

Koch, J. J., Porter, C. J. & Ackerman, M. J., Oct 1 2005, In : Pediatric Cardiology. 26, 5, p. 646-650 5 p.

Research output: Contribution to journalArticle

4 Scopus citations

Anesthesia for patients with congenital long QT syndrome

Kies, S. J., Pabelick, C. M., Hurley, H. A., White, R. D. & Ackerman, M. J., Jan 1 2005, In : Anesthesiology. 102, 1, p. 204-210 7 p.

Research output: Contribution to journalReview article

99 Scopus citations
3 Scopus citations

Blockade of HERG channels by HIV protease inhibitors

Anson, B. D., Weaver, J. G. R., Ackerman, M. J., Akinsete, O., Henry, K., January, C. T. & Badley, A. D., Feb 19 2005, In : Lancet. 365, 9460, p. 682-686 5 p.

Research output: Contribution to journalArticle

101 Scopus citations
35 Scopus citations

Common human SCN5A polymorphisms have altered electrophysiology when expressed in Q1077 splice variants

Tan, B. H., Valdivia, C. R., Rok, B. A., Ye, B., Ruwaldt, K. M., Tester, D. J., Ackerman, M. J. & Makielski, J. C., Jul 1 2005, In : Heart rhythm. 2, 7, p. 741-747 7 p.

Research output: Contribution to journalArticle

103 Scopus citations

Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing

Tester, D. J., Will, M. L., Haglund, C. M. & Ackerman, M. J., May 1 2005, In : Heart rhythm. 2, 5, p. 507-517 11 p.

Research output: Contribution to journalArticle

417 Scopus citations

Cost-effectiveness analysis of genetic testing for familial long QT syndrome in symptomatic index cases

Phillips, K. A., Ackerman, M. J., Sakowski, J. & Berul, C. I., Dec 2005, In : Heart rhythm. 2, 12, p. 1294-1300 7 p.

Research output: Contribution to journalArticle

36 Scopus citations

Drug-induced torsades de pointes: The evolving role of pharmacogenetics

Fitzgerald, P. T. & Ackerman, M. J., Nov 2005, In : Heart rhythm. 2, 11 SUPPL. 2, p. S30-S37

Research output: Contribution to journalArticle

70 Scopus citations

Electrocardiographic features in Andersen-Tawil syndrome patients with KCNJ2 mutations: Characteristic T-U-wave patterns predict the KCNJ2 genotype

Zhang, L., Benson, D. W., Tristani-Firouzi, M., Ptacek, L. J., Tawil, R., Schwartz, P. J., George, A. L., Horie, M., Andelfinger, G., Snow, G. L., Fu, Y. H., Ackerman, M. J. & Vincent, G. M., May 31 2005, In : Circulation. 111, 21, p. 2720-2726 7 p.

Research output: Contribution to journalArticle

213 Scopus citations