Michael John Ackerman, MD, PhD, FACC

  • 37462 Citations
  • 106 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2008

Genetic testing

Tester, D. J. & Ackerman, M. J., Dec 1 2008, Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. Springer London, p. 444-458 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Impact of Septal Myectomy on Left Atrial Volume and Left Ventricular Diastolic Filling Patterns: An Echocardiographic Study of Young Patients with Obstructive Hypertrophic Cardiomyopathy

Menon, S. C., Ackerman, M. J., Ommen, S. R., Cabalka, A. K., Hagler, D. J., O'Leary, P. W., Dearani, J. A., Cetta, F. & Eidem, B. W., Jun 1 2008, In : Journal of the American Society of Echocardiography. 21, 6, p. 684-688 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Long-QT syndrome after age 40

Goldenberg, I., Moss, A. J., Peterson, D. R., McNitt, S., Zareba, W., Andrews, M. L., Robinson, J. L., Locati, E. H., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Napolitano, C., Priori, S. G., Qi, M., Schwartz, P. J., Towbin, J. A., Vincent, G. M. & Zhang, L., Apr 29 2008, In : Circulation. 117, 17, p. 2192-2201 10 p.

Research output: Contribution to journalArticle

112 Scopus citations

Mechanical Dysfunction in Extreme QT Prolongation

Vyas, H., O'Leary, P. W., Earing, M. G., Cetta, F. & Ackerman, M. J., May 2008, In : Journal of the American Society of Echocardiography. 21, 5, p. 511.e15-511.e17

Research output: Contribution to journalArticle

15 Scopus citations

Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C

Landstrom, A. P., Parvatiyar, M. S., Pinto, J. R., Marquardt, M. L., Bos, J. M., Tester, D. J., Ommen, S. R., Potter, J. D. & Ackerman, M. J., Aug 1 2008, In : Journal of Molecular and Cellular Cardiology. 45, 2, p. 281-288 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy

Olivotto, I., Girolami, F., Ackerman, M. J., Nistri, S., Bos, J. M., Zachara, E., Ommen, S. R., Theis, J. L., Vaubel, R. A., Re, F., Armentano, C., Poggesi, C., Torricelli, F. & Cecchi, F., Jun 2008, In : Mayo Clinic proceedings. 83, 6, p. 630-638 9 p.

Research output: Contribution to journalArticle

259 Scopus citations

Novel gene and mutation discovery in congenital long QT syndrome: Let's keep looking where the street lamp standeth

Tester, D. J. & Ackerman, M. J., Sep 1 2008, In : Heart rhythm. 5, 9, p. 1282-1284 3 p.

Research output: Contribution to journalEditorial

16 Scopus citations
48 Scopus citations

Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with long-QT syndrome

Sale, H., Wang, J., O'Hara, T. J., Tester, D. J., Phartiyal, P., He, J. Q., Rudy, Y., Ackerman, M. J. & Robertson, G. A., Sep 26 2008, In : Circulation research. 103, 7, p. e81-e95

Research output: Contribution to journalArticle

85 Scopus citations
70 Scopus citations

Prevalence, clinical significance, and natural history of left ventricular apical aneurysms in hypertrophic cardiomyopathy

Maron, M. S., Finley, J. J., Bos, J. M., Hauser, T. H., Manning, W. J., Haas, T. S., Lesser, J. R., Udelson, J. E., Ackerman, M. J. & Maron, B. J., Oct 7 2008, In : Circulation. 118, 15, p. 1541-1549 9 p.

Research output: Contribution to journalArticle

304 Scopus citations

Prevalence of early-onset atrial fibrillation in congenital long QT syndrome

Johnson, J. N., Tester, D. J., Perry, J., Salisbury, B. A., Reed, C. R. & Ackerman, M. J., May 1 2008, In : Heart rhythm. 5, 5, p. 704-709 6 p.

Research output: Contribution to journalArticle

116 Scopus citations

Provocative testing in inherited arrhythmias

Shimizu, W. & Ackerman, M. J., Dec 1 2008, Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. Springer London, p. 424-433 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Relationship between sex, shape, and substrate in hypertrophic cardiomyopathy

Bos, J. M., Theis, J. L., Tajik, A. J., Gersh, B. J., Ommen, S. R. & Ackerman, M. J., Jun 1 2008, In : American Heart Journal. 155, 6, p. 1128-1134 7 p.

Research output: Contribution to journalArticle

17 Scopus citations

Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital Long-QT syndrome

Goldenberg, I., Moss, A. J., Peterson, D. R., McNitt, S., Zareba, W., Andrews, M. L., Robinson, J. L., Locati, E. H., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Napolitano, C., Priori, S. G., Qi, M., Schwartz, P. J., Towbin, J. A., Vincent, G. M. & Zhang, L., Apr 29 2008, In : Circulation. 117, 17, p. 2184-2191 8 p.

Research output: Contribution to journalArticle

204 Scopus citations

Risk of death in the long QT syndrome when a sibling has died

Kaufman, E. S., McNitt, S., Moss, A. J., Zareba, W., Robinson, J. L., Hall, W. J., Ackerman, M. J., Benhorin, J., Locati, E. T., Napolitano, C., Priori, S. G., Schwartz, P. J., Towbin, J. A., Vincent, G. M. & Zhang, L., Jun 1 2008, In : Heart rhythm. 5, 6, p. 831-836 6 p.

Research output: Contribution to journalArticle

55 Scopus citations

Significance of Left Atrial Volume in Patients < 20 Years of Age With Hypertrophic Cardiomyopathy

Menon, S. C., Ackerman, M. J., Cetta, F., O'Leary, P. W. & Eidem, B. W., Nov 15 2008, In : American Journal of Cardiology. 102, 10, p. 1390-1393 4 p.

Research output: Contribution to journalArticle

28 Scopus citations

Sudden cardiac death in infancy: Focus on prolonged repolarization

Schwartz, P. J., Stramba-Badiale, M., Crotti, L. & Ackerman, M. J., Dec 1 2008, Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention. Springer London, p. 924-933 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Sudden infant death syndrome: Study of genes pertinent to cardiorespiratory and autonomic regulation

Weese-Mayer, D. E., Ackerman, M. J., Marazita, M. L. & Berry-Kravis, E. M., Jan 1 2008, Genetic Basis for Respiratory Control Disorders. Springer US, p. 85-109 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sudden infant death syndrome: Genetic studies in cardiorespiratory and autonomic regulation

Weese-Mayer, D. E., Berry-Kravis, E. M., Ackerman, M. J. & Marazita, M. L., Jan 1 2008, Sleep and Breathing in Children: Developmental Changes in Breathing During Sleep, Second Edition. CRC Press, Vol. 224. p. 224-313 90 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Suppression of atrial fibrillation with mexiletine pharmacotherapy in a young woman with type 1 long QT syndrome

El Yaman, M., Perry, J., Makielski, J. C. & Ackerman, M. J., Mar 1 2008, In : Heart rhythm. 5, 3, p. 472-474 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex

Ueda, K., Valdivia, C., Medeiros-Domingo, A., Tester, D. J., Vatta, M., Farrugia, G., Ackerman, M. J. & Makielski, J. C., Jul 8 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 27, p. 9355-9360 6 p.

Research output: Contribution to journalArticle

249 Scopus citations

Systems approach to understanding electromechanical activity in the human heart a national heart, lung, and blood institute workshop summary

Rudy, Y., Ackerman, M. J., Bers, D. M., Clancy, C. E., Houser, S. R., London, B., McCulloch, A. D., Przywara, D. A., Rasmusson, R. L., Solaro, J. R., Trayanova, N. A., Van Wagoner, D. R., Varro, A., Weiss, J. N. & Lathrop, D. A., Sep 9 2008, In : Circulation. 118, 11, p. 1202-1211 10 p.

Research output: Contribution to journalArticle

53 Scopus citations

Unmasking concealed long QT syndrome

Ackerman, M. J., Jan 1 2008, In : Heart rhythm. 5, 1, p. 8-10 3 p.

Research output: Contribution to journalEditorial

8 Scopus citations

Ventricular ectopy during treadmill exercise stress testing in the evaluation of long QT syndrome

Horner, J. M. & Ackerman, M. J., Dec 1 2008, In : Heart rhythm. 5, 12, p. 1690-1694 5 p.

Research output: Contribution to journalArticle

24 Scopus citations
2007

A mechanism for sudden infant death syndrome (SIDS): Stress-induced leak via ryanodine receptors

Tester, D. J., Dura, M., Carturan, E., Reiken, S., Wronska, A., Marks, A. R. & Ackerman, M. J., Jun 1 2007, In : Heart rhythm. 4, 6, p. 733-739 7 p.

Research output: Contribution to journalArticle

125 Scopus citations

An algorithm for QT interval monitoring in neonatal intensive care units

Helfenbein, E. D., Ackerman, M. J., Rautaharju, P. M., Zhou, S. H., Gregg, R. E., Lindauer, J. M., Miller, D., Wang, J. J., Kresge, S. S., Babaeizadeh, S., Feild, D. Q. & Michaud, F. P., Nov 1 2007, In : Journal of Electrocardiology. 40, 6 SUPPL. 1, p. S103-S110

Research output: Contribution to journalArticle

13 Scopus citations

A novel C-terminal truncation SCN5A mutation from a patient with sick sinus syndrome, conduction disorder and ventricular tachycardia

Tan, B. H., Iturralde-Torres, P., Medeiros-Domingo, A., Nava, S., Tester, D. J., Valdivia, C. R., Tusié-Luna, T., Ackerman, M. J. & Makielski, J. C., Dec 1 2007, In : Cardiovascular research. 76, 3, p. 409-417 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Beta-blocker Efficacy in Long-QT Syndrome Patients with Mutations in the Pore and Nonpore Regions of the hERG Potassium-channel Gene

Moss, A. J., Peterson, D. R., Zareba, W., Seth, R., McNitt, S. A., Andrews, M. L., Qi, M., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Robinson, J. L., Towbin, J. A., Vincent, G. M. & Zhang, L., Nov 12 2007, New Arrhythmia Technologies. Blackwell Publishing, p. 91-94 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cardiovascular disease

Khositseth, A. & Ackerman, M. J., Dec 1 2007, Molecular Pathology in Clinical Practice. Springer New York, p. 161-177 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Characterization of the cardiac sodium channel SCN5A mutation, N1325S, in single murine ventricular myocytes

Yong, S. L., Ni, Y., Zhang, T., Tester, D. J., Ackerman, M. J. & Wang, Q. K., Jan 12 2007, In : Biochemical and Biophysical Research Communications. 352, 2, p. 378-383 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene

Moss, A. J., Shimizu, W., Wilde, A. A. M., Towbin, J. A., Zareba, W., Robinson, J. L., Qi, M., Vincent, G. M., Ackerman, M. J., Kaufman, E. S., Hofman, N., Seth, R., Kamakura, S., Miyamoto, Y., Goldenberg, I., Andrews, M. L. & McNitt, S., May 1 2007, In : Circulation. 115, 19, p. 2481-2489 9 p.

Research output: Contribution to journalArticle

314 Scopus citations

Clínica y genética en el síndrome de QT largo

Translated title of the contribution: Clinical and genetic characteristics of long QT syndromeMedeiros-Domingo, A., Iturralde-Torres, P. & Ackerman, M. J., Jul 2007, In : Revista Espanola de Cardiologia. 60, 7, p. 739-752 14 p.

Research output: Contribution to journalReview article

51 Scopus citations

Diagnostic miscues in congenital long-QT syndrome

Taggart, N. W., Haglund, C. M., Tester, D. J. & Ackerman, M. J., May 1 2007, In : Circulation. 115, 20, p. 2613-2620 8 p.

Research output: Contribution to journalArticle

161 Scopus citations

Does low-dose droperidol administration increase the risk of drug-induced QT prolongation and torsade de pointes in the general surgical population?

Nuttall, G. A., Eckerman, K. M., Jacob, K. A., Pawlaski, E. M., Wigersma, S. K., Marienau, M. E. S., Oliver, W. C., Narr, B. J. & Ackerman, M. J., Oct 2007, In : Anesthesiology. 107, 4, p. 531-536 6 p.

Research output: Contribution to journalArticle

75 Scopus citations

Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy

Pandit, B., Sarkozy, A., Pennacchio, L. A., Carta, C., Oishi, K., Martinelli, S., Pogna, E. A., Schackwitz, W., Ustaszewska, A., Landstrom, A., Bos, J. M., Ommen, S. R., Esposito, G., Lepri, F., Faul, C., Mundel, P., López Siguero, J. P., Tenconi, R., Selicorni, A., Rossi, C. & 9 others, Mazzanti, L., Torrente, I., Marino, B., Digilio, M. C., Zampino, G., Ackerman, M. J., Dallapiccola, B., Tartaglia, M. & Gelb, B. D., Aug 2007, In : Nature Genetics. 39, 8, p. 1007-1012 6 p.

Research output: Contribution to journalArticle

456 Scopus citations

Genetics of hypertrophic cardiomyopathy: One, two, or more diseases?

Bos, J. M., Ommen, S. R. & Ackerman, M. J., May 1 2007, In : Current opinion in cardiology. 22, 3, p. 193-199 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Inherited arrhythmias: A National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function

Lehnart, S. E., Ackerman, M. J., Benson, D. W., Brugada, R., Clancy, C. E., Donahue, J. K., George, A. L., Grant, A. O., Groft, S. C., January, C. T., Lathrop, D. A., Lederer, W. J., Makielski, J. C., Mohler, P. J., Moss, A., Nerbonne, J. M., Olson, T. M., Przywara, D. A., Towbin, J. A., Wang, L. H. & 1 others, Marks, A. R., Nov 1 2007, In : Circulation. 116, 20, p. 2325-2345 21 p.

Research output: Contribution to journalArticle

197 Scopus citations

KCNJ2 mutations in arrhythmia patients referred for LQT testing: A mutation T305A with novel effect on rectification properties

Eckhardt, L. L., Farley, A. L., Rodriguez, E., Ruwaldt, K., Hammill, D., Tester, D. J., Ackerman, M. J. & Makielski, J. C., Mar 1 2007, In : Heart rhythm. 4, 3, p. 323-329 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Long QT Syndrome and Pregnancy

Seth, R., Moss, A. J., McNitt, S., Zareba, W., Andrews, M. L., Qi, M., Robinson, J. L., Goldenberg, I., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Locati, E. H., Napolitano, C., Priori, S. G., Schwartz, P. J., Towbin, J. A., Vincent, G. M. & Zhang, L., Mar 13 2007, In : Journal of the American College of Cardiology. 49, 10, p. 1092-1098 7 p.

Research output: Contribution to journalArticle

185 Scopus citations

Long QT Syndrome in Adults

Sauer, A. J., Moss, A. J., McNitt, S., Peterson, D. R., Zareba, W., Robinson, J. L., Qi, M., Goldenberg, I., Hobbs, J. B., Ackerman, M. J., Benhorin, J., Hall, W. J., Kaufman, E. S., Locati, E. H., Napolitano, C., Priori, S. G., Schwartz, P. J., Towbin, J. A., Vincent, G. M. & Zhang, L., Jan 23 2007, In : Journal of the American College of Cardiology. 49, 3, p. 329-337 9 p.

Research output: Contribution to journalArticle

282 Scopus citations

Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L) mutations in sudden infant death syndrome

Van Norstrand, D. W., Valdivia, C. R., Tester, D. J., Ueda, K., London, B., Makielski, J. C. & Ackerman, M. J., Nov 1 2007, In : Circulation. 116, 20, p. 2253-2259 7 p.

Research output: Contribution to journalArticle

140 Scopus citations

Mutation in glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias

London, B., Michalec, M., Mehdi, H., Zhu, X., Kerchner, L., Sanyal, S., Viswanathan, P. C., Pfahnl, A. E., Shang, L. L., Madhusudanan, M., Baty, C. J., Lagana, S., Aleong, R., Gutmann, R., Ackerman, M. J., McNamara, D. M., Weiss, R. & Dudley, S. C., Nov 1 2007, In : Circulation. 116, 20, p. 2260-2268 9 p.

Research output: Contribution to journalArticle

343 Scopus citations

Mutation of an A-kinase-anchoring protein causes long-QT syndrome

Chen, L., Marquardt, M. L., Tester, D. J., Sampson, K. J., Ackerman, M. J. & Kass, R. S., Dec 26 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 52, p. 20990-20995 6 p.

Research output: Contribution to journalArticle

239 Scopus citations

Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans

Landstrom, A. P., Weisleder, N., Batalden, K. B., Martijn Bos, J., Tester, D. J., Ommen, S. R., Wehrens, X. H. T., Claycomb, W. C., Ko, J. K., Hwang, M., Pan, Z., Ma, J. & Ackerman, M. J., Jun 1 2007, In : Journal of Molecular and Cellular Cardiology. 42, 6, p. 1026-1035 10 p.

Research output: Contribution to journalArticle

118 Scopus citations

Novel mechanism for sudden infant death syndrome: Persistent late sodium current secondary to mutations in caveolin-3

Cronk, L. B., Ye, B., Kaku, T., Tester, D. J., Vatta, M., Makielski, J. C. & Ackerman, M. J., Feb 1 2007, In : Heart rhythm. 4, 2, p. 161-166 6 p.

Research output: Contribution to journalArticle

179 Scopus citations

Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms

McKellar, S. H., Tester, D. J., Yagubyan, M., Majumdar, R., Ackerman, M. J. & Sundt, T. M., Aug 1 2007, In : Journal of Thoracic and Cardiovascular Surgery. 134, 2, p. 290-296 7 p.

Research output: Contribution to journalArticle

173 Scopus citations

Postmortem Long QT Syndrome Genetic Testing for Sudden Unexplained Death in the Young

Tester, D. J. & Ackerman, M. J., Jan 16 2007, In : Journal of the American College of Cardiology. 49, 2, p. 240-246 7 p.

Research output: Contribution to journalArticle

286 Scopus citations

Recommendations and considerations related to preparticipation screening for cardiovascular abnormalities in competitive athletes: 2007 Update: A scientific statement from the American Heart Association council on nutrition, physical activity, and metabolism: Endorsed by the American College of Cardiology foundation

Maron, B. J., Thompson, P. D., Ackerman, M. J., Balady, G., Berger, S., Cohen, D., Dimeff, R., Douglas, P. S., Glover, D. W., Hutter, A. M., Krauss, M. D., Maron, M. S., Mitten, M. J., Roberts, W. O. & Puffer, J. C., Mar 1 2007, In : Circulation. 115, 12, p. 1643-1655 13 p.

Research output: Contribution to journalReview article

745 Scopus citations