Michael John Ackerman, MD, PhD, FACC

  • 35809 Citations
  • 105 Scopus h-Index
1991 …2020

Research output per year

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Research Output

2008

Sudden infant death syndrome: Genetic studies in cardiorespiratory and autonomic regulation

Weese-Mayer, D. E., Berry-Kravis, E. M., Ackerman, M. J. & Marazita, M. L., Jan 1 2008, Sleep and Breathing in Children: Developmental Changes in Breathing During Sleep, Second Edition. CRC Press, Vol. 224. p. 224-313 90 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sudden infant death syndrome: Study of genes pertinent to cardiorespiratory and autonomic regulation

Weese-Mayer, D. E., Ackerman, M. J., Marazita, M. L. & Berry-Kravis, E. M., 2008, Genetic Basis for Respiratory Control Disorders. Springer US, p. 85-109 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Suppression of atrial fibrillation with mexiletine pharmacotherapy in a young woman with type 1 long QT syndrome

El Yaman, M., Perry, J., Makielski, J. C. & Ackerman, M. J., Mar 2008, In : Heart Rhythm. 5, 3, p. 472-474 3 p.

Research output: Contribution to journalArticle

12 Scopus citations

Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex

Ueda, K., Valdivia, C., Medeiros-Domingo, A., Tester, D. J., Vatta, M., Farrugia, G., Ackerman, M. J. & Makielski, J. C., Jul 8 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 27, p. 9355-9360 6 p.

Research output: Contribution to journalArticle

248 Scopus citations

Systems approach to understanding electromechanical activity in the human heart a national heart, lung, and blood institute workshop summary

Rudy, Y., Ackerman, M. J., Bers, D. M., Clancy, C. E., Houser, S. R., London, B., McCulloch, A. D., Przywara, D. A., Rasmusson, R. L., Solaro, J. R., Trayanova, N. A., Van Wagoner, D. R., Varro, A., Weiss, J. N. & Lathrop, D. A., Sep 9 2008, In : Circulation. 118, 11, p. 1202-1211 10 p.

Research output: Contribution to journalArticle

51 Scopus citations

Unmasking concealed long QT syndrome

Ackerman, M. J., Jan 2008, In : Heart Rhythm. 5, 1, p. 8-10 3 p.

Research output: Contribution to journalArticle

8 Scopus citations

Ventricular ectopy during treadmill exercise stress testing in the evaluation of long QT syndrome

Horner, J. M. & Ackerman, M. J., Dec 2008, In : Heart Rhythm. 5, 12, p. 1690-1694 5 p.

Research output: Contribution to journalArticle

24 Scopus citations
2007

A mechanism for sudden infant death syndrome (SIDS): Stress-induced leak via ryanodine receptors

Tester, D. J., Dura, M., Carturan, E., Reiken, S., Wronska, A., Marks, A. R. & Ackerman, M. J., Jun 2007, In : Heart Rhythm. 4, 6, p. 733-739 7 p.

Research output: Contribution to journalArticle

123 Scopus citations

An algorithm for QT interval monitoring in neonatal intensive care units

Helfenbein, E. D., Ackerman, M. J., Rautaharju, P. M., Zhou, S. H., Gregg, R. E., Lindauer, J. M., Miller, D., Wang, J. J., Kresge, S. S., Babaeizadeh, S., Feild, D. Q. & Michaud, F. P., Nov 2007, In : Journal of Electrocardiology. 40, 6 SUPPL. 1

Research output: Contribution to journalArticle

13 Scopus citations

A novel C-terminal truncation SCN5A mutation from a patient with sick sinus syndrome, conduction disorder and ventricular tachycardia

Tan, B. H., Iturralde-Torres, P., Medeiros-Domingo, A., Nava, S., Tester, D. J., Valdivia, C. R., Tusié-Luna, T., Ackerman, M. J. & Makielski, J. C., Dec 1 2007, In : Cardiovascular Research. 76, 3, p. 409-417 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Beta-blocker Efficacy in Long-QT Syndrome Patients with Mutations in the Pore and Nonpore Regions of the hERG Potassium-channel Gene

Moss, A. J., Peterson, D. R., Zareba, W., Seth, R., McNitt, S. A., Andrews, M. L., Qi, M., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Robinson, J. L., Towbin, J. A., Vincent, G. M. & Zhang, L., Nov 12 2007, New Arrhythmia Technologies. Blackwell Publishing, p. 91-94 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cardiovascular disease

Khositseth, A. & Ackerman, M. J., 2007, Molecular Pathology in Clinical Practice. Springer New York, p. 161-177 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Characterization of the cardiac sodium channel SCN5A mutation, N1325S, in single murine ventricular myocytes

Yong, S. L., Ni, Y., Zhang, T., Tester, D. J., Ackerman, M. J. & Wang, Q. K., Jan 12 2007, In : Biochemical and Biophysical Research Communications. 352, 2, p. 378-383 6 p.

Research output: Contribution to journalArticle

24 Scopus citations

Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene

Moss, A. J., Shimizu, W., Wilde, A. A. M., Towbin, J. A., Zareba, W., Robinson, J. L., Qi, M., Vincent, G. M., Ackerman, M. J., Kaufman, E. S., Hofman, N., Seth, R., Kamakura, S., Miyamoto, Y., Goldenberg, I., Andrews, M. L. & McNitt, S., May 2007, In : Circulation. 115, 19, p. 2481-2489 9 p.

Research output: Contribution to journalArticle

308 Scopus citations

Clínica y genética en el síndrome de QT largo

Translated title of the contribution: Clinical and genetic characteristics of long QT syndromeMedeiros-Domingo, A., Iturralde-Torres, P. & Ackerman, M. J., Jul 2007, In : Revista Espanola de Cardiologia. 60, 7, p. 739-752 14 p.

Research output: Contribution to journalArticle

49 Scopus citations

Diagnostic miscues in congenital long-QT syndrome

Taggart, N. W., Haglund, C. M., Tester, D. J. & Ackerman, M. J., May 2007, In : Circulation. 115, 20, p. 2613-2620 8 p.

Research output: Contribution to journalArticle

159 Scopus citations

Does low-dose droperidol administration increase the risk of drug-induced QT prolongation and torsade de pointes in the general surgical population?

Nuttall, G. A., Eckerman, K. M., Jacob, K. A., Pawlaski, E. M., Wigersma, S. K., Marienau, M. E. S., Oliver, W. C., Narr, B. J. & Ackerman, M. J., Oct 2007, In : Anesthesiology. 107, 4, p. 531-536 6 p.

Research output: Contribution to journalArticle

74 Scopus citations

Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy

Pandit, B., Sarkozy, A., Pennacchio, L. A., Carta, C., Oishi, K., Martinelli, S., Pogna, E. A., Schackwitz, W., Ustaszewska, A., Landstrom, A., Bos, J. M., Ommen, S. R., Esposito, G., Lepri, F., Faul, C., Mundel, P., López Siguero, J. P., Tenconi, R., Selicorni, A., Rossi, C. & 9 others, Mazzanti, L., Torrente, I., Marino, B., Digilio, M. C., Zampino, G., Ackerman, M. J., Dallapiccola, B., Tartaglia, M. & Gelb, B. D., Aug 2007, In : Nature Genetics. 39, 8, p. 1007-1012 6 p.

Research output: Contribution to journalArticle

447 Scopus citations

Genetics of hypertrophic cardiomyopathy: One, two, or more diseases?

Bos, J. M., Ommen, S. R. & Ackerman, M. J., May 2007, In : Current Opinion in Cardiology. 22, 3, p. 193-199 7 p.

Research output: Contribution to journalArticle

69 Scopus citations

Inherited arrhythmias: A National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function

Lehnart, S. E., Ackerman, M. J., Benson, D. W., Brugada, R., Clancy, C. E., Donahue, J. K., George, A. L., Grant, A. O., Groft, S. C., January, C. T., Lathrop, D. A., Lederer, W. J., Makielski, J. C., Mohler, P. J., Moss, A., Nerbonne, J. M., Olson, T. M., Przywara, D. A., Towbin, J. A., Wang, L. H. & 1 others, Marks, A. R., Nov 2007, In : Circulation. 116, 20, p. 2325-2345 21 p.

Research output: Contribution to journalArticle

198 Scopus citations

KCNJ2 mutations in arrhythmia patients referred for LQT testing: A mutation T305A with novel effect on rectification properties

Eckhardt, L. L., Farley, A. L., Rodriguez, E., Ruwaldt, K., Hammill, D., Tester, D. J., Ackerman, M. J. & Makielski, J. C., Mar 2007, In : Heart Rhythm. 4, 3, p. 323-329 7 p.

Research output: Contribution to journalArticle

28 Scopus citations

Long QT Syndrome and Pregnancy

Seth, R., Moss, A. J., McNitt, S., Zareba, W., Andrews, M. L., Qi, M., Robinson, J. L., Goldenberg, I., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Locati, E. H., Napolitano, C., Priori, S. G., Schwartz, P. J., Towbin, J. A., Vincent, G. M. & Zhang, L., Mar 13 2007, In : Journal of the American College of Cardiology. 49, 10, p. 1092-1098 7 p.

Research output: Contribution to journalArticle

181 Scopus citations

Long QT Syndrome in Adults

Sauer, A. J., Moss, A. J., McNitt, S., Peterson, D. R., Zareba, W., Robinson, J. L., Qi, M., Goldenberg, I., Hobbs, J. B., Ackerman, M. J., Benhorin, J., Hall, W. J., Kaufman, E. S., Locati, E. H., Napolitano, C., Priori, S. G., Schwartz, P. J., Towbin, J. A., Vincent, G. M. & Zhang, L., Jan 23 2007, In : Journal of the American College of Cardiology. 49, 3, p. 329-337 9 p.

Research output: Contribution to journalArticle

275 Scopus citations

Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L) mutations in sudden infant death syndrome

Van Norstrand, D. W., Valdivia, C. R., Tester, D. J., Ueda, K., London, B., Makielski, J. C. & Ackerman, M. J., Nov 2007, In : Circulation. 116, 20, p. 2253-2259 7 p.

Research output: Contribution to journalArticle

140 Scopus citations

Mutation in glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias

London, B., Michalec, M., Mehdi, H., Zhu, X., Kerchner, L., Sanyal, S., Viswanathan, P. C., Pfahnl, A. E., Shang, L. L., Madhusudanan, M., Baty, C. J., Lagana, S., Aleong, R., Gutmann, R., Ackerman, M. J., McNamara, D. M., Weiss, R. & Dudley, S. C., Nov 2007, In : Circulation. 116, 20, p. 2260-2268 9 p.

Research output: Contribution to journalArticle

342 Scopus citations

Mutation of an A-kinase-anchoring protein causes long-QT syndrome

Chen, L., Marquardt, M. L., Tester, D. J., Sampson, K. J., Ackerman, M. J. & Kass, R. S., Dec 26 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 52, p. 20990-20995 6 p.

Research output: Contribution to journalArticle

235 Scopus citations

Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans

Landstrom, A. P., Weisleder, N., Batalden, K. B., Martijn Bos, J., Tester, D. J., Ommen, S. R., Wehrens, X. H. T., Claycomb, W. C., Ko, J. K., Hwang, M., Pan, Z., Ma, J. & Ackerman, M. J., Jun 2007, In : Journal of Molecular and Cellular Cardiology. 42, 6, p. 1026-1035 10 p.

Research output: Contribution to journalArticle

115 Scopus citations

Novel mechanism for sudden infant death syndrome: Persistent late sodium current secondary to mutations in caveolin-3

Cronk, L. B., Ye, B., Kaku, T., Tester, D. J., Vatta, M., Makielski, J. C. & Ackerman, M. J., Feb 2007, In : Heart Rhythm. 4, 2, p. 161-166 6 p.

Research output: Contribution to journalArticle

179 Scopus citations

Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms

McKellar, S. H., Tester, D. J., Yagubyan, M., Majumdar, R., Ackerman, M. J. & Sundt, T. M., Aug 2007, In : Journal of Thoracic and Cardiovascular Surgery. 134, 2, p. 290-296 7 p.

Research output: Contribution to journalArticle

169 Scopus citations

Postmortem Long QT Syndrome Genetic Testing for Sudden Unexplained Death in the Young

Tester, D. J. & Ackerman, M. J., Jan 16 2007, In : Journal of the American College of Cardiology. 49, 2, p. 240-246 7 p.

Research output: Contribution to journalArticle

284 Scopus citations

Recommendations and considerations related to preparticipation screening for cardiovascular abnormalities in competitive athletes: 2007 Update: A scientific statement from the American Heart Association council on nutrition, physical activity, and metabolism: Endorsed by the American College of Cardiology foundation

Maron, B. J., Thompson, P. D., Ackerman, M. J., Balady, G., Berger, S., Cohen, D., Dimeff, R., Douglas, P. S., Glover, D. W., Hutter, A. M., Krauss, M. D., Maron, M. S., Mitten, M. J., Roberts, W. O. & Puffer, J. C., Mar 2007, In : Circulation. 115, 12, p. 1643-1655 13 p.

Research output: Contribution to journalArticle

731 Scopus citations

SCN4B-encoded sodium channel β4 subunit in congenital long-QT syndrome

Medeiros-Domingo, A., Kaku, T., Tester, D. J., Iturralde-Torres, P., Itty, A., Ye, B., Valdivia, C., Ueda, K., Canizales-Quinteros, S., Tusié-Luna, M. T., Makielski, J. C. & Ackerman, M. J., Jul 2007, In : Circulation. 116, 2, p. 134-142 9 p.

Research output: Contribution to journalArticle

258 Scopus citations

Sudden Infant Death Syndrome: Review of implicated genetic factors

Weese-Mayer, D. E., Ackerman, M. J., Marazita, M. L. & Berry-Kravis, E. M., Apr 15 2007, In : American Journal of Medical Genetics, Part A. 143, 8, p. 771-788 18 p.

Research output: Contribution to journalArticle

101 Scopus citations

Surgical septal myectomy decreases the risk for appropriate implantable cardioverter defibrillator discharge in obstructive hypertrophic cardiomyopathy

McLeod, C. J., Ommen, S. R., Ackerman, M. J., Weivoda, P. L., Shen, W. K., Dearani, J. A., Schaff, H. V., Tajik, A. J. & Gersh, B. J., Nov 2007, In : European Heart Journal. 28, 21, p. 2583-2588 6 p.

Research output: Contribution to journalArticle

112 Scopus citations

TGFβ inducible early gene-1 (TIEG1) and cardiac hypertrophy: Discovery and characterization of a novel signaling pathway

Rajamannan, N. M., Subramaniam, M., Abraham, T. P., Vasile, V. C., Ackerman, M. J., Monroe, D. G., Chew, T. L. & Spelsberg, T. C., Feb 1 2007, In : Journal of Cellular Biochemistry. 100, 2, p. 315-325 11 p.

Research output: Contribution to journalArticle

40 Scopus citations

The common long-QT syndrome mutation KCNQ1/A341V causes unusually severe clinical manifestations in patients with different ethnic backgrounds: Toward a mutation-specific risk stratification

Crotti, L., Spazzolini, C., Schwartz, P. J., Shimizu, W., Denjoy, I., Schulze-Bahr, E., Zaklyazminskaya, E. V., Swan, H., Ackerman, M. J., Moss, A. J., Wilde, A. A. M., Horie, M., Brink, P. A., Insolia, R., De Ferrari, G. M. & Crimi, G., Nov 2007, In : Circulation. 116, 21, p. 2366-2375 10 p.

Research output: Contribution to journalArticle

112 Scopus citations

Usefulness of Brain Natriuretic Peptide Levels in the Clinical Evaluation of Patients With Hypertrophic Cardiomyopathy

Binder, J., Ommen, S. R., Chen, H. H., Ackerman, M. J., Tajik, A. J. & Jaffe, A. S., Aug 15 2007, In : American Journal of Cardiology. 100, 4, p. 712-714 3 p.

Research output: Contribution to journalArticle

19 Scopus citations

Ventricular ectopy during REM sleep: Implications for nocturnal sudden cardiac death

Garcia-Touchard, A., Somers, V., Kara, T., Nykodym, J., Shamsuzzaman, A., Lanfranchi, P. & Ackerman, M. J., May 2007, In : Nature Clinical Practice Cardiovascular Medicine. 4, 5, p. 284-288 5 p.

Research output: Contribution to journalArticle

17 Scopus citations
2006

Acquired long QT syndrome secondary to cesium chloride supplement

Vyas, H., Johnson, K., Houlihan, R., Bauer, B. A. & Ackerman, M. J., Dec 2006, In : Journal of Alternative and Complementary Medicine. 12, 10, p. 1011-1014 4 p.

Research output: Contribution to journalArticle

16 Scopus citations

Allelic dropout in long QT syndrome genetic testing: A possible mechanism underlying false-negative results

Tester, D. J., Cronk, L. B., Carr, J. L., Schulz, V., Salisbury, B. A., Judson, R. S. & Ackerman, M. J., Jul 2006, In : Heart Rhythm. 3, 7, p. 815-821 7 p.

Research output: Contribution to journalArticle

37 Scopus citations

A missense mutation in a ubiquitously expressed protein, vinculin, confers susceptibility to hypertrophic cardiomyopathy

Vasile, V. C., Ommen, S. R., Edwards, W. D. & Ackerman, M. J., Jul 7 2006, In : Biochemical and Biophysical Research Communications. 345, 3, p. 998-1003 6 p.

Research output: Contribution to journalArticle

66 Scopus citations

Clinical course and risk stratification of patients affected with the Jervell and Lange-Nielsen syndrome

Goldenberg, I., Moss, A. J., Zareba, W., Mcnitt, S., Robinson, J. L., Qi, M., Towbin, J. A., Ackerman, M. J. & Murphy, L., Nov 2006, In : Journal of Cardiovascular Electrophysiology. 17, 11, p. 1161-1168 8 p.

Research output: Contribution to journalArticle

69 Scopus citations

Echocardiographic-determined septal morphology in Z-disc hypertrophic cardiomyopathy

Theis, J. L., Martijn Bos, J., Bartleson, V. B., Will, M. L., Binder, J., Vatta, M., Towbin, J. A., Gersh, B. J., Ommen, S. R. & Ackerman, M. J., Dec 29 2006, In : Biochemical and Biophysical Research Communications. 351, 4, p. 896-902 7 p.

Research output: Contribution to journalArticle

63 Scopus citations

Echocardiography-guided genetic testing in hypertrophic cardiomyopathy: Septal morphological features predict the presence of myofilament mutations

Binder, J., Ommen, S. R., Gersh, B. J., Van Driest, S. L., Tajik, A. J., Nishimura, R. A. & Ackerman, M. J., 2006, In : Mayo Clinic Proceedings. 81, 4, p. 459-467 9 p.

Research output: Contribution to journalArticle

149 Scopus citations

Effect of Clinical Phenotype on Yield of Long QT Syndrome Genetic Testing

Tester, D. J., Will, M. L., Haglund, C. M. & Ackerman, M. J., Feb 21 2006, In : Journal of the American College of Cardiology. 47, 4, p. 764-768 5 p.

Research output: Contribution to journalArticle

136 Scopus citations

Epinephrine QT stress testing in congenital long QT syndrome

Vyas, H. & Ackerman, M. J., Oct 2006, In : Journal of Electrocardiology. 39, 4 SUPPL.

Research output: Contribution to journalArticle

32 Scopus citations

Epinephrine QT stress testing in the evaluation of congenital long-QT syndrome: Diagnostic accuracy of the paradoxical QT response

Vyas, H., Hejlik, J. & Ackerman, M. J., Mar 2006, In : Circulation. 113, 11, p. 1385-1392 8 p.

Research output: Contribution to journalArticle

180 Scopus citations

Gastrointestinal symptoms in families of patients with an SCN5A-encoded cardiac channelopathy: Evidence of an intestinal channelopathy

Locke, G. R., Ackerman, M. J., Zinsmeister, A. R., Thapa, P. & Farrugia, G., Jun 2006, In : American Journal of Gastroenterology. 101, 6, p. 1299-1304 6 p.

Research output: Contribution to journalArticle

58 Scopus citations